CY1122061T1 - Χιμαιρικος διαλυτος υποδοχεας ιντερλευκινης-10 και θεραπευτικη χρηση αυτου - Google Patents

Χιμαιρικος διαλυτος υποδοχεας ιντερλευκινης-10 και θεραπευτικη χρηση αυτου

Info

Publication number
CY1122061T1
CY1122061T1 CY20191100997T CY191100997T CY1122061T1 CY 1122061 T1 CY1122061 T1 CY 1122061T1 CY 20191100997 T CY20191100997 T CY 20191100997T CY 191100997 T CY191100997 T CY 191100997T CY 1122061 T1 CY1122061 T1 CY 1122061T1
Authority
CY
Cyprus
Prior art keywords
receptor
therapeutic use
soluble interleukin
chimeric soluble
interleukin
Prior art date
Application number
CY20191100997T
Other languages
English (en)
Inventor
Gilberto Filaci
Daniela FENOGLIO
Original Assignee
Mediolanum Farmaceutici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediolanum Farmaceutici S.P.A. filed Critical Mediolanum Farmaceutici S.P.A.
Publication of CY1122061T1 publication Critical patent/CY1122061T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)

Abstract

Χιμαιρικός διαλυτός υποδοχέας ιντερλευκίνης 10 και σχετική χρήση στη θεραπευτική αντιμετώπιση όγκων και στη θεραπευτική αντιμετώπιση νόσων που χαρακτηρίζονται από υψηλή παραγωγή ιντερλευκίνης 10, όπως ο συστηματικός ερυθηματώδης λύκος.
CY20191100997T 2015-04-29 2019-09-23 Χιμαιρικος διαλυτος υποδοχεας ιντερλευκινης-10 και θεραπευτικη χρηση αυτου CY1122061T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITUB20150391 2015-04-29
PCT/IB2016/052359 WO2016174575A1 (en) 2015-04-29 2016-04-26 A soluble chimeric interleukin-10 receptor and therapeutic use thereof

Publications (1)

Publication Number Publication Date
CY1122061T1 true CY1122061T1 (el) 2020-11-25

Family

ID=53765409

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191100997T CY1122061T1 (el) 2015-04-29 2019-09-23 Χιμαιρικος διαλυτος υποδοχεας ιντερλευκινης-10 και θεραπευτικη χρηση αυτου

Country Status (15)

Country Link
US (1) US20180086809A1 (el)
EP (1) EP3288965B1 (el)
JP (1) JP2018518945A (el)
KR (1) KR20170138569A (el)
CN (1) CN107531771A (el)
CA (1) CA2979973A1 (el)
CY (1) CY1122061T1 (el)
DK (1) DK3288965T3 (el)
ES (1) ES2744342T3 (el)
HK (1) HK1245814B (el)
HU (1) HUE046343T2 (el)
PL (1) PL3288965T3 (el)
PT (1) PT3288965T (el)
SI (1) SI3288965T1 (el)
WO (1) WO2016174575A1 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10906957B2 (en) 2016-09-27 2021-02-02 Epicentrx, Inc. Immunomodulatory fusion proteins
MX2020003672A (es) * 2017-09-27 2020-08-03 Epicentrx Inc Proteinas de fusion inmunomoduladora.
CN116125074A (zh) * 2022-12-13 2023-05-16 北京东方百泰生物科技股份有限公司 一种IL-10-Fc融合蛋白与其受体结合活性的检测方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789192A (en) * 1992-12-10 1998-08-04 Schering Corporation Mammalian receptors for interleukin-10 (IL-10)
US6165476A (en) * 1997-07-10 2000-12-26 Beth Israel Deaconess Medical Center Fusion proteins with an immunoglobulin hinge region linker
CA2405709A1 (en) * 2000-04-12 2001-10-25 Human Genome Sciences, Inc. Albumin fusion proteins
JP4635255B2 (ja) * 2003-09-02 2011-02-23 独立行政法人産業技術総合研究所 抗体医薬
BRPI0406605B8 (pt) * 2003-11-13 2021-05-25 Hanmi Holdings Co Ltd conjugado de proteína, método para a preparação do mesmo e composição farmacêutica para intensificar a duração e estabilidade in vivo de um polipeptídeo fisiologicamente ativo
WO2008147143A2 (en) * 2007-05-30 2008-12-04 Postech Academy-Industry Foundation Immunoglobulin fusion proteins
WO2010040105A2 (en) * 2008-10-02 2010-04-08 Trubion Pharmaceuticals, Inc. Cd86 antagonist multi-target binding proteins
WO2013177398A2 (en) * 2012-05-25 2013-11-28 Janssen Biotech, Inc. Non-natural consensus albumin binding domains

Also Published As

Publication number Publication date
CN107531771A (zh) 2018-01-02
SI3288965T1 (sl) 2019-10-30
WO2016174575A1 (en) 2016-11-03
PT3288965T (pt) 2019-10-15
JP2018518945A (ja) 2018-07-19
US20180086809A1 (en) 2018-03-29
PL3288965T3 (pl) 2019-11-29
KR20170138569A (ko) 2017-12-15
HUE046343T2 (hu) 2020-02-28
ES2744342T3 (es) 2020-02-24
CA2979973A1 (en) 2016-11-03
EP3288965A1 (en) 2018-03-07
HK1245814B (zh) 2020-06-19
EP3288965B1 (en) 2019-06-26
DK3288965T3 (da) 2019-09-23

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