MX2016016288A - Polipeptidos efectores de la subunidad a de la toxina shiga resistentes a la disociacion por proteasa y moleculas dirigidas a las celulas que los comprenden. - Google Patents
Polipeptidos efectores de la subunidad a de la toxina shiga resistentes a la disociacion por proteasa y moleculas dirigidas a las celulas que los comprenden.Info
- Publication number
- MX2016016288A MX2016016288A MX2016016288A MX2016016288A MX2016016288A MX 2016016288 A MX2016016288 A MX 2016016288A MX 2016016288 A MX2016016288 A MX 2016016288A MX 2016016288 A MX2016016288 A MX 2016016288A MX 2016016288 A MX2016016288 A MX 2016016288A
- Authority
- MX
- Mexico
- Prior art keywords
- cell
- molecules
- targeted molecules
- shiga toxin
- protease
- Prior art date
Links
- 108010079723 Shiga Toxin Proteins 0.000 title abstract 4
- 238000003776 cleavage reaction Methods 0.000 title abstract 4
- 239000012636 effector Substances 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- -1 e.g. Substances 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000009546 growth abnormality Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
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Abstract
La presente invención proporciona moléculas resistentes a la disociación por proteasa que comprenden los polipéptidos efectores de la toxina Shiga capaces de exhibir potentes funciones de la toxina Shiga (por ejemplo, el encaminamiento subcelular y la citotoxicidad). La presente invención también proporciona moléculas resistentes a la disociación por proteasa dirigidas a las células para dirigirse a tipos específicos de células, por ejemplo, las células infectadas o malignas. Ciertas moléculas de la presente invención son citotóxicas, y ciertas moléculas dirigidas a las células de la presente invención se puede utilizar para la aniquilación dirigida de tipos específicos de células, y para el tratamiento de una variedad de enfermedades, trastornos y afecciones, incluyendo cánceres, tumores, anormalidades del crecimiento, trastornos inmunológicos e infecciones microbianas. Ciertas moléculas dirigidas a las células de la invención exhiben una mejor tolerabilidad in vivo comparándose con las moléculas dirigidas a las células relacionadas que comprenden los polipéptidos efectores de la toxina Shiga de tipo silvestre sensibles a la disociación por proteasa. Las moléculas dirigidas a las células de la invención pueden suministrar materiales adicionales, tales como, por ejemplo, antígenos, agentes citotóxicos y agentes promotores de la detección, hacia el interior de las células objetivo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462010918P | 2014-06-11 | 2014-06-11 | |
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