MX2018001208A - Moleculas con direccion a las celulas que comprenden efectores de la subunidad a de la toxina shiga y epitopos de celulas-t cd8+. - Google Patents
Moleculas con direccion a las celulas que comprenden efectores de la subunidad a de la toxina shiga y epitopos de celulas-t cd8+.Info
- Publication number
- MX2018001208A MX2018001208A MX2018001208A MX2018001208A MX2018001208A MX 2018001208 A MX2018001208 A MX 2018001208A MX 2018001208 A MX2018001208 A MX 2018001208A MX 2018001208 A MX2018001208 A MX 2018001208A MX 2018001208 A MX2018001208 A MX 2018001208A
- Authority
- MX
- Mexico
- Prior art keywords
- cell
- targeting molecules
- shiga toxin
- immune
- epitope
- Prior art date
Links
- 108010079723 Shiga Toxin Proteins 0.000 title 1
- 239000012636 effector Substances 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 5
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 abstract 3
- 102000043129 MHC class I family Human genes 0.000 abstract 2
- 108091054437 MHC class I family Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000037361 pathway Effects 0.000 abstract 2
- 241000251556 Chordata Species 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 210000001723 extracellular space Anatomy 0.000 abstract 1
- 230000009546 growth abnormality Effects 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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- C—CHEMISTRY; METALLURGY
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- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
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- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
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Abstract
La presente invención proporciona moléculas con dirección a las células que pueden suministrar una carga de epítopo de células-T CD8+ a la senda de presentación de MHC clase I de la célula. Las moléculas con dirección a las células de la invención se pueden utilizar para suministrar virtualmente cualquier epítopo de células-T CD8+ desde un espacio extracelular hasta la senda de MHC clase I de una célula objetivo, la cual puede ser una célula maligna y/o una célula no inmunitaria. La célula objetivo entonces puede exhibir, sobre una superficie celular, el epítopo de células-T CD8+ suministrado que forma complejo con la molécula de MHC I. Las moléculas con dirección a las células de la invención tienen usos que incluyen el marcado dirigido y/o la aniquilación de tipos de células específicos dentro de una mezcla de tipos de células, incluyendo dentro de un cordado, así como la estimulación de respuestas inmunitarias benéficas. Las moléculas con dirección a las células de la invención tienen usos, por ejemplo, en el tratamiento de una variedad de enfermedades, trastornos y afecciones, incluyendo cánceres, tumores, anormalidades del crecimiento, trastornos inmunológicos e infecciones microbianas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562197048P | 2015-07-26 | 2015-07-26 | |
US14/965,882 US20160177284A1 (en) | 2014-01-27 | 2015-12-10 | Cell-targeted molecules comprising amino-terminus proximal or amino-terminal shiga toxin a subunit effector regions |
PCT/US2016/043902 WO2017019623A2 (en) | 2015-07-26 | 2016-07-25 | Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018001208A true MX2018001208A (es) | 2018-03-26 |
Family
ID=57885282
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018001208A MX2018001208A (es) | 2015-07-26 | 2016-07-25 | Moleculas con direccion a las celulas que comprenden efectores de la subunidad a de la toxina shiga y epitopos de celulas-t cd8+. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20170143814A1 (es) |
EP (1) | EP3325510A2 (es) |
JP (2) | JP6884133B2 (es) |
KR (1) | KR20180030085A (es) |
CN (1) | CN107922493A (es) |
AU (1) | AU2016297920A1 (es) |
CA (1) | CA2991259A1 (es) |
HK (1) | HK1248258A1 (es) |
IL (1) | IL256317B (es) |
MX (1) | MX2018001208A (es) |
WO (1) | WO2017019623A2 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160340394A1 (en) | 2014-01-27 | 2016-11-24 | Molecular Templates, Inc. | De-immunized shiga toxin a subunit effector polypeptides for applications in mammals |
US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
CN113831416A (zh) | 2014-06-11 | 2021-12-24 | 分子模板公司 | 耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子 |
CN108064247B (zh) | 2015-02-05 | 2022-06-03 | 分子模板公司 | 包含志贺毒素a亚基效应物区域的多价cd20结合分子及其富集组合物 |
LT3303373T (lt) | 2015-05-30 | 2020-07-10 | Molecular Templates, Inc. | Deimunizuoto shiga toksino a subvieneto karkasai ir juos apimančios ląstelės taikinio molekulės |
WO2018106895A1 (en) | 2016-12-07 | 2018-06-14 | Molecular Templates, Inc. | Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation |
JP7082424B2 (ja) | 2017-01-25 | 2022-06-08 | モレキュラー テンプレーツ,インク. | 脱免疫化された志賀毒素aサブユニットエフェクター及びcd8+t細胞エピトープを含む細胞標的化分子 |
EP3573652A1 (en) * | 2018-04-17 | 2019-12-04 | Molecular Templates, Inc. | Her2-targeting molecules comprising de-immunized, shiga toxin a subunit scaffolds |
AU2019290192A1 (en) * | 2018-06-21 | 2021-01-07 | Shattuck Labs, Inc. | Heterodimeric proteins and uses thereof |
WO2020081493A1 (en) | 2018-10-16 | 2020-04-23 | Molecular Templates, Inc. | Pd-l1 binding proteins |
EP3914610A1 (en) | 2019-01-23 | 2021-12-01 | Millennium Pharmaceuticals, Inc. | Cd38-binding proteins comprising de-immunized shiga toxin a subunit effectors |
WO2020154475A1 (en) | 2019-01-23 | 2020-07-30 | Molecular Templates, Inc. | Proteins comprising modified immunoglobulin variable light chains |
WO2021055816A1 (en) | 2019-09-18 | 2021-03-25 | Molecular Templates, Inc. | Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds |
KR20220081977A (ko) | 2019-09-18 | 2022-06-16 | 몰레큘러 템플레이츠, 인코퍼레이션. | 시가 독소 a 서브유닛 스캐폴드를 포함하는 pd-l1 결합분자(pd-l1 binding molecules comprising shiga toxin a subunit scaffolds) |
US20220195050A1 (en) * | 2020-12-16 | 2022-06-23 | Molecular Templates, Inc. | Clinical methods for use of a pd-l1-binding molecule comprising a shiga toxin effector |
CA3213295A1 (en) | 2021-03-17 | 2022-09-22 | Molecular Templates, Inc. | Pd-l1 binding proteins comprising shiga toxin a subunit scaffolds and cd8+ t cell antigens |
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US7838216B1 (en) | 1986-03-05 | 2010-11-23 | The United States Of America, As Represented By The Department Of Health And Human Services | Human gene related to but distinct from EGF receptor gene |
DE69031120T2 (de) | 1989-05-19 | 1998-01-15 | Genentech Inc | Her2 extrazellulare domäne |
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2016
- 2016-07-25 CA CA2991259A patent/CA2991259A1/en not_active Abandoned
- 2016-07-25 AU AU2016297920A patent/AU2016297920A1/en not_active Abandoned
- 2016-07-25 KR KR1020187003735A patent/KR20180030085A/ko not_active Application Discontinuation
- 2016-07-25 WO PCT/US2016/043902 patent/WO2017019623A2/en active Application Filing
- 2016-07-25 EP EP16751070.0A patent/EP3325510A2/en not_active Withdrawn
- 2016-07-25 MX MX2018001208A patent/MX2018001208A/es unknown
- 2016-07-25 JP JP2018501187A patent/JP6884133B2/ja active Active
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2017
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- 2017-12-14 IL IL256317A patent/IL256317B/en unknown
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2018
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2021
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WO2017019623A2 (en) | 2017-02-02 |
CN107922493A (zh) | 2018-04-17 |
IL256317A (en) | 2018-02-28 |
JP2018524006A (ja) | 2018-08-30 |
KR20180030085A (ko) | 2018-03-21 |
US20170143814A1 (en) | 2017-05-25 |
EP3325510A2 (en) | 2018-05-30 |
JP2021119783A (ja) | 2021-08-19 |
AU2016297920A1 (en) | 2018-01-18 |
IL256317B (en) | 2021-10-31 |
HK1248258A1 (zh) | 2018-10-12 |
WO2017019623A3 (en) | 2017-03-09 |
CA2991259A1 (en) | 2017-02-02 |
JP6884133B2 (ja) | 2021-06-09 |
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