HK1248258A1 - 包含志賀毒素a亞基效應物和cd8+ t-細胞表位的細胞靶向分子 - Google Patents

包含志賀毒素a亞基效應物和cd8+ t-細胞表位的細胞靶向分子

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Publication number
HK1248258A1
HK1248258A1 HK18107823.8A HK18107823A HK1248258A1 HK 1248258 A1 HK1248258 A1 HK 1248258A1 HK 18107823 A HK18107823 A HK 18107823A HK 1248258 A1 HK1248258 A1 HK 1248258A1
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HK
Hong Kong
Prior art keywords
cell
shiga toxin
targeting molecules
effectors
subunit
Prior art date
Application number
HK18107823.8A
Other languages
English (en)
Inventor
Eric Poma
Erin Willert
Jason Kim
Original Assignee
Molecular Templates Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/965,882 external-priority patent/US20160177284A1/en
Application filed by Molecular Templates Inc filed Critical Molecular Templates Inc
Publication of HK1248258A1 publication Critical patent/HK1248258A1/zh

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HK18107823.8A 2015-07-26 2018-06-15 包含志賀毒素a亞基效應物和cd8+ t-細胞表位的細胞靶向分子 HK1248258A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562197048P 2015-07-26 2015-07-26
US14/965,882 US20160177284A1 (en) 2014-01-27 2015-12-10 Cell-targeted molecules comprising amino-terminus proximal or amino-terminal shiga toxin a subunit effector regions
PCT/US2016/043902 WO2017019623A2 (en) 2015-07-26 2016-07-25 Cell-targeting molecules comprising shiga toxin a subunit effectors and cd8+ t-cell epitopes

Publications (1)

Publication Number Publication Date
HK1248258A1 true HK1248258A1 (zh) 2018-10-12

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HK18107823.8A HK1248258A1 (zh) 2015-07-26 2018-06-15 包含志賀毒素a亞基效應物和cd8+ t-細胞表位的細胞靶向分子

Country Status (11)

Country Link
US (1) US20170143814A1 (zh)
EP (1) EP3325510A2 (zh)
JP (2) JP6884133B2 (zh)
KR (1) KR20180030085A (zh)
CN (1) CN107922493A (zh)
AU (1) AU2016297920A1 (zh)
CA (1) CA2991259A1 (zh)
HK (1) HK1248258A1 (zh)
IL (1) IL256317B (zh)
MX (1) MX2018001208A (zh)
WO (1) WO2017019623A2 (zh)

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US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
CN113831416A (zh) 2014-06-11 2021-12-24 分子模板公司 耐受蛋白酶切割的志贺毒素a亚基效应子多肽和包含其的细胞靶向分子
CN108064247B (zh) 2015-02-05 2022-06-03 分子模板公司 包含志贺毒素a亚基效应物区域的多价cd20结合分子及其富集组合物
LT3303373T (lt) 2015-05-30 2020-07-10 Molecular Templates, Inc. Deimunizuoto shiga toksino a subvieneto karkasai ir juos apimančios ląstelės taikinio molekulės
WO2018106895A1 (en) 2016-12-07 2018-06-14 Molecular Templates, Inc. Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation
JP7082424B2 (ja) 2017-01-25 2022-06-08 モレキュラー テンプレーツ，インク． 脱免疫化された志賀毒素ａサブユニットエフェクター及びｃｄ８＋ｔ細胞エピトープを含む細胞標的化分子
EP3573652A1 (en) * 2018-04-17 2019-12-04 Molecular Templates, Inc. Her2-targeting molecules comprising de-immunized, shiga toxin a subunit scaffolds
AU2019290192A1 (en) * 2018-06-21 2021-01-07 Shattuck Labs, Inc. Heterodimeric proteins and uses thereof
WO2020081493A1 (en) 2018-10-16 2020-04-23 Molecular Templates, Inc. Pd-l1 binding proteins
EP3914610A1 (en) 2019-01-23 2021-12-01 Millennium Pharmaceuticals, Inc. Cd38-binding proteins comprising de-immunized shiga toxin a subunit effectors
WO2020154475A1 (en) 2019-01-23 2020-07-30 Molecular Templates, Inc. Proteins comprising modified immunoglobulin variable light chains
WO2021055816A1 (en) 2019-09-18 2021-03-25 Molecular Templates, Inc. Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds
KR20220081977A (ko) 2019-09-18 2022-06-16 몰레큘러 템플레이츠, 인코퍼레이션. 시가 독소 a 서브유닛 스캐폴드를 포함하는 pd-l1 결합분자(pd-l1 binding molecules comprising shiga toxin a subunit scaffolds)
US20220195050A1 (en) * 2020-12-16 2022-06-23 Molecular Templates, Inc. Clinical methods for use of a pd-l1-binding molecule comprising a shiga toxin effector
CA3213295A1 (en) 2021-03-17 2022-09-22 Molecular Templates, Inc. Pd-l1 binding proteins comprising shiga toxin a subunit scaffolds and cd8+ t cell antigens

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JP2018524006A (ja) 2018-08-30
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US20170143814A1 (en) 2017-05-25
EP3325510A2 (en) 2018-05-30
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AU2016297920A1 (en) 2018-01-18
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