MD3768284T2 - Compoziţii de entrecoccus flagellin pentru utilizare în terapie - Google Patents

Compoziţii de entrecoccus flagellin pentru utilizare în terapie

Info

Publication number
MD3768284T2
MD3768284T2 MDE20210096T MDE20210096T MD3768284T2 MD 3768284 T2 MD3768284 T2 MD 3768284T2 MD E20210096 T MDE20210096 T MD E20210096T MD E20210096 T MDE20210096 T MD E20210096T MD 3768284 T2 MD3768284 T2 MD 3768284T2
Authority
MD
Moldova
Prior art keywords
compositions
flagellin
entrecoccus
therapy
diseases
Prior art date
Application number
MDE20210096T
Other languages
English (en)
Inventor
Imke Elisabeth MULDER
Emma Raftis
Emma Elizabeth Clare Hennessy
Delphine Louise Claudette Laute-Caly
Philip Cowie
Original Assignee
4D Pharma Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1804384.4A external-priority patent/GB201804384D0/en
Priority claimed from GBGB1809953.1A external-priority patent/GB201809953D0/en
Priority claimed from GBGB1811900.8A external-priority patent/GB201811900D0/en
Priority claimed from GBGB1812378.6A external-priority patent/GB201812378D0/en
Priority claimed from GBGB1813423.9A external-priority patent/GB201813423D0/en
Priority claimed from GBGB1813444.5A external-priority patent/GB201813444D0/en
Priority claimed from GBGB1816834.4A external-priority patent/GB201816834D0/en
Priority claimed from GBGB1817641.2A external-priority patent/GB201817641D0/en
Priority claimed from GBGB1901218.6A external-priority patent/GB201901218D0/en
Priority claimed from GBGB1901199.8A external-priority patent/GB201901199D0/en
Priority claimed from GBGB1901993.4A external-priority patent/GB201901993D0/en
Priority claimed from GBGB1901992.6A external-priority patent/GB201901992D0/en
Application filed by 4D Pharma Res Ltd filed Critical 4D Pharma Res Ltd
Publication of MD3768284T2 publication Critical patent/MD3768284T2/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Invenţia furnizează compoziţii cuprinzȃnd polipeptide flagellin din tulpini bacteriene şi utilizarea unor astfel de compoziţii în tratamentul bolilor.
MDE20210096T 2018-03-19 2019-03-19 Compoziţii de entrecoccus flagellin pentru utilizare în terapie MD3768284T2 (ro)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
GBGB1804384.4A GB201804384D0 (en) 2018-03-19 2018-03-19 Compositions
EP18178350 2018-06-18
GBGB1809953.1A GB201809953D0 (en) 2018-06-18 2018-06-18 Compositions
GBGB1811900.8A GB201811900D0 (en) 2018-07-20 2018-07-20 Compositions comprising bacterial strains
GBGB1812378.6A GB201812378D0 (en) 2018-07-30 2018-07-30 Compositions comprising bacterial strains
GBGB1813423.9A GB201813423D0 (en) 2018-08-17 2018-08-17 Compositions comprising bacterial strains
GBGB1813444.5A GB201813444D0 (en) 2018-08-17 2018-08-17 Compositions
GBGB1816834.4A GB201816834D0 (en) 2018-10-16 2018-10-16 Compositions
GBGB1817641.2A GB201817641D0 (en) 2018-10-29 2018-10-29 Compositions comprising bacterial strains
GBGB1901218.6A GB201901218D0 (en) 2019-01-29 2019-01-29 Compositions
GBGB1901199.8A GB201901199D0 (en) 2019-01-29 2019-01-29 Compositions comprising bacterial strains
GBGB1901993.4A GB201901993D0 (en) 2019-02-13 2019-02-13 Compositions
GBGB1901992.6A GB201901992D0 (en) 2019-02-13 2019-02-13 Compositions comprising bacterial strains
PCT/EP2019/056809 WO2019180000A1 (en) 2018-03-19 2019-03-19 Compositions

Publications (1)

Publication Number Publication Date
MD3768284T2 true MD3768284T2 (ro) 2022-06-30

Family

ID=65955185

Family Applications (1)

Application Number Title Priority Date Filing Date
MDE20210096T MD3768284T2 (ro) 2018-03-19 2019-03-19 Compoziţii de entrecoccus flagellin pentru utilizare în terapie

Country Status (23)

Country Link
US (3) US11419931B2 (ro)
EP (3) EP4046644A1 (ro)
JP (3) JP2021518129A (ro)
KR (2) KR20210003096A (ro)
CN (2) CN112004543A (ro)
AU (2) AU2019238358A1 (ro)
BR (2) BR112020019008A2 (ro)
CA (2) CA3094297A1 (ro)
DK (1) DK3768284T3 (ro)
ES (1) ES2908826T3 (ro)
HR (1) HRP20220368T1 (ro)
HU (1) HUE058151T2 (ro)
IL (2) IL277421B (ro)
LT (1) LT3768284T (ro)
MA (1) MA52128A (ro)
MD (1) MD3768284T2 (ro)
MX (2) MX2020009733A (ro)
PL (1) PL3768284T3 (ro)
RS (1) RS63090B1 (ro)
SG (2) SG11202009254YA (ro)
SI (1) SI3768284T1 (ro)
TW (2) TW202003000A (ro)
WO (2) WO2019180051A1 (ro)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE058151T2 (hu) 2018-03-19 2022-07-28 4D Pharma Res Ltd Enterococcusból származó flagellin készítményei terápiában történõ alkalmazásra
WO2021113500A2 (en) * 2019-12-03 2021-06-10 Board Of Regents, The University Of Texas System Combination therapies for the treatment of cancer
EP4161541A2 (en) * 2020-06-09 2023-04-12 Flagship Pioneering Innovations VI, LLC Physiologically acceptable compositions containing microorganisms or microbial products
US20230111960A1 (en) * 2021-10-08 2023-04-13 Iowa State University Research Foundation, Inc. Use of dopamine producing products to increase vaccine efficacy
CN115287243B (zh) * 2022-04-15 2023-06-06 集美大学 一株变形假单胞菌flgK基因沉默菌株及其构建方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5132418A (en) 1980-02-29 1992-07-21 University Patents, Inc. Process for preparing polynucleotides
US4500707A (en) 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4668777A (en) 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
US4973679A (en) 1981-03-27 1990-11-27 University Patents, Inc. Process for oligonucleo tide synthesis using phosphormidite intermediates
US4373071A (en) 1981-04-30 1983-02-08 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US5153319A (en) 1986-03-31 1992-10-06 University Patents, Inc. Process for preparing polynucleotides
US5047524A (en) 1988-12-21 1991-09-10 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
US5262530A (en) 1988-12-21 1993-11-16 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
JPH08259450A (ja) 1995-03-17 1996-10-08 Nichinichi Seiyaku Kk インターフェロン産生増強剤
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
EP0904784A1 (en) 1997-09-22 1999-03-31 N.V. Nutricia Probiotic nutritional preparation
GB0127916D0 (en) 2001-11-21 2002-01-16 Rowett Res Inst Method
US20040009937A1 (en) * 2002-01-31 2004-01-15 Wei Chen Methods and composition for delivering nucleic acids and/or proteins to the respiratory system
US20080025977A1 (en) 2003-04-14 2008-01-31 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of CD59
US20060228369A1 (en) 2005-04-11 2006-10-12 Program For Appropriate Technology In Health Stabilization and preservation of temperature-sensitive vaccines
JP2007116991A (ja) 2005-10-28 2007-05-17 Eternal Light General Institute Inc 機能性食品
EP3594248B1 (en) 2006-10-27 2021-08-04 Capsugel Belgium NV Hydroxypropyl methyl cellulose hard capsules and process of manufacture
EP1958647A1 (en) 2007-02-15 2008-08-20 Helmholtz-Zentrum für Infektionsforschung GmbH Pharmaceutical composition with bacteria for tumor treatment
TWI490003B (zh) * 2007-03-19 2015-07-01 Morishita Jintan Co 經口疫苗
CN102046198A (zh) * 2008-04-25 2011-05-04 系统生物学研究所 鞭毛蛋白多肽疫苗
BR112012011331B8 (pt) * 2009-10-06 2021-05-25 Panacela Labs Llc vetor compreendendo ácidos nucleicos que codificam um receptor tipo toll e um agonista do mesmo
US9376473B2 (en) 2011-01-10 2016-06-28 Cleveland Biolabs, Inc. Use of Toll-Like Receptor agonist for treating cancer
EP2731572B1 (en) 2011-07-13 2021-04-07 Pharmaxis Ltd. Improvements relating to delivery devices
GB201112091D0 (en) 2011-07-14 2011-08-31 Gt Biolog Ltd Bacterial strains isolated from pigs
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
ES2408279B1 (es) 2011-12-15 2014-09-09 Universidad De Las Palmas De Gran Canaria Bacteria acido láctica probiótica
FR2989002B1 (fr) 2012-04-10 2015-05-15 Beepratte Lab Compositions a base de probiotiques et d'un complexe beepollen/argile, leur preparation et leurs utilisations en nutrition et therapeutique
CA2884816A1 (en) 2012-09-13 2014-03-20 Massachusetts Institute Of Technology Programmable drug delivery profiles of tumor-targeted bacteria
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
JP6578283B2 (ja) * 2014-02-12 2019-09-18 トランサルガエ イスラエル リミテッド 藻類をベースとした食用ワクチン
GB201520502D0 (en) * 2015-11-20 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520497D0 (en) 2015-11-20 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
CN112569262A (zh) * 2015-11-20 2021-03-30 4D制药研究有限公司 包含细菌菌株的组合物
EP3630942B1 (en) * 2017-05-24 2022-11-30 4D Pharma Research Limited Compositions comprising bacterial strain
AR112328A1 (es) 2017-07-05 2019-10-16 Evelo Biosciences Inc Composiciones y métodos para tratamiento de cáncer usando bifidobacterium animalis ssp. lactis
BR112020002212A2 (pt) 2017-08-10 2020-07-28 4D Pharma Research Limited composições compreendendo cepas bacterianas
HUE058151T2 (hu) 2018-03-19 2022-07-28 4D Pharma Res Ltd Enterococcusból származó flagellin készítményei terápiában történõ alkalmazásra

Also Published As

Publication number Publication date
CA3094139A1 (en) 2019-09-26
EP3768284A1 (en) 2021-01-27
US20210138058A1 (en) 2021-05-13
EP3768284B1 (en) 2022-01-05
IL277421A (en) 2020-11-30
CN112004543A (zh) 2020-11-27
WO2019180000A1 (en) 2019-09-26
JP2021518129A (ja) 2021-08-02
CN111886018A (zh) 2020-11-03
US11419931B2 (en) 2022-08-23
US20220257745A1 (en) 2022-08-18
EP4046644A1 (en) 2022-08-24
SI3768284T1 (sl) 2022-04-29
HRP20220368T1 (hr) 2022-06-24
WO2019180051A1 (en) 2019-09-26
BR112020018818A2 (pt) 2021-05-04
LT3768284T (lt) 2022-04-11
DK3768284T3 (da) 2022-03-07
MA52128A (fr) 2021-01-27
CA3094297A1 (en) 2019-09-26
SG11202009259VA (en) 2020-10-29
AU2019239048A1 (en) 2020-11-05
JP2021518414A (ja) 2021-08-02
EP3768285A1 (en) 2021-01-27
SG11202009254YA (en) 2020-10-29
PL3768284T3 (pl) 2022-04-11
TW202003000A (zh) 2020-01-16
HUE058151T2 (hu) 2022-07-28
AU2019238358A1 (en) 2020-10-08
ES2908826T3 (es) 2022-05-04
KR20200134255A (ko) 2020-12-01
BR112020019008A2 (pt) 2020-12-29
IL277421B (en) 2022-04-01
AU2019239048B2 (en) 2022-07-21
TW202003001A (zh) 2020-01-16
KR102578117B1 (ko) 2023-09-12
KR20210003096A (ko) 2021-01-11
US11857614B2 (en) 2024-01-02
MX2020009733A (es) 2022-10-27
RS63090B1 (sr) 2022-04-29
IL277422A (en) 2020-11-30
JP2023100747A (ja) 2023-07-19
MX2020009736A (es) 2021-01-08
US20210169950A1 (en) 2021-06-10

Similar Documents

Publication Publication Date Title
CY1122344T1 (el) Blautia stercosis και wexlerae για χρηση στην θεραπευτικη αγωγη φλεγμονωδων και αυτοανοσων νοσων
CY1121473T1 (el) Συνθεσεις που περιλαμβανουν βακτηριακα στελεχη
CY1124013T1 (el) Συνθεσεις που περιλαμβανουν βακτηριακα στελεχη
CY1122184T1 (el) Συνθεσεις περιλαμβανουσες βακτηριακα στελεχη
CY1122581T1 (el) Συνθεσεις που περιλαμβανουν βακτηριακα στελεχη
MD3768284T2 (ro) Compoziţii de entrecoccus flagellin pentru utilizare în terapie
CY1122148T1 (el) Συνθεσεις που περιεχουν βακτηριακα στελεχη
WO2018229236A3 (en) COMPOSITIONS COMPRISING BACTERIAL STRAINS
MA44890B1 (fr) Compositions comprenant des souches bactériennes
SV2018005614A (es) Inhibidores peptidicos del receptor de interleucina 23 y uso para tratar enfermedades inflamatorias
MA41013B1 (fr) Compositions comprenant des souches bactériennes
BR112019017403A2 (pt) composições e métodos para o tratamento de câncer
MX2020006191A (es) Bacteriocinas terapeuticas.
MX2022002740A (es) Conjugados de il-2 y metodos de uso para tratar enfermedades autoinmunes.
PH12021550122A1 (en) Solubilized apyrases, methods and use
MX2020001632A (es) Composiciones que comprenden cepas bacterianas.
MX2020011027A (es) Constructos de anticuerpos biespecíficos trivalentes.
MA40642A (fr) Nouveaux dérivés peptidiques et leurs utilisations
MX2021002444A (es) Compuestos y metodos para el tratamiento de infecciones fungicas.
EA202092204A1 (ru) Композиции
EA201992649A1 (ru) Композиции, содержащие бактериальные штаммы
CY1124623T1 (el) Συνθεσεις που περιλαμβανουν βακτηριακα στελεχη
EA201992647A1 (ru) Композиции, содержащие бактериальные штаммы
MA46980B1 (fr) Compositions comprenant des souches bactériennes
MA45476B1 (fr) Compositions comprenant des souches bactériennes