DE60333004D1 - Antikrebsmittel mit verotoxinvarianten - Google Patents

Antikrebsmittel mit verotoxinvarianten

Info

Publication number
DE60333004D1
DE60333004D1 DE60333004T DE60333004T DE60333004D1 DE 60333004 D1 DE60333004 D1 DE 60333004D1 DE 60333004 T DE60333004 T DE 60333004T DE 60333004 T DE60333004 T DE 60333004T DE 60333004 D1 DE60333004 D1 DE 60333004D1
Authority
DE
Germany
Prior art keywords
verotoxin
subunit
attenuated
anticrope
variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60333004T
Other languages
English (en)
Inventor
Xiaoyan Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE60333004D1 publication Critical patent/DE60333004D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE60333004T 2002-02-04 2003-02-03 Antikrebsmittel mit verotoxinvarianten Expired - Lifetime DE60333004D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002026577 2002-02-04
PCT/JP2003/001043 WO2003066854A1 (fr) 2002-02-04 2003-02-03 Agent anticancereux utilisant des variantes de verotoxines

Publications (1)

Publication Number Publication Date
DE60333004D1 true DE60333004D1 (de) 2010-07-29

Family

ID=27677819

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60333004T Expired - Lifetime DE60333004D1 (de) 2002-02-04 2003-02-03 Antikrebsmittel mit verotoxinvarianten

Country Status (8)

Country Link
US (3) US20050163807A1 (de)
EP (1) EP1496116B1 (de)
JP (1) JP4214397B2 (de)
AT (1) ATE471371T1 (de)
AU (1) AU2003208097A1 (de)
DE (1) DE60333004D1 (de)
HK (1) HK1073130A1 (de)
WO (1) WO2003066854A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070059382A1 (en) * 2005-09-09 2007-03-15 Board Of Regents, Univ. And Comm. College System Of Nevada... Medical treatment of breast cancer with boric acid materials
EP2207793A2 (de) * 2007-10-08 2010-07-21 Rutgers, The State University Nicht toxische shigatoxinmutanten-zusammensetzungen und entsprechende verfahren
AU2010286248A1 (en) 2009-08-28 2012-04-12 The Hospital For Sick Children Use of a holotoxin to reduce endoplasmic reticulum-associated degradation of misfolded proteins
KR102266001B1 (ko) 2012-06-28 2021-06-16 유니버셜 인스트루먼츠 코퍼레이션 융통성 있는 조립 기계, 시스템 및 방법
JP6548630B2 (ja) * 2013-03-12 2019-07-24 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. 特定の細胞型の選択的死滅のための細胞標的化結合領域と志賀毒素ａサブユニット領域とを含む細胞毒性タンパク質
EP3868776A1 (de) 2014-01-27 2021-08-25 Molecular Templates, Inc. Mhc-klasse-i-epitope freisetzende polypeptide
JP6678596B2 (ja) 2014-02-07 2020-04-08 ユニヴァーサル インストゥルメンツ コーポレイションＵｎｉｖｅｒｓａｌ Ｉｎｓｔｒｕｍｅｎｔｓ Ｃｏｒｐｏｒａｔｉｏｎ ポンプとモーターを持つピックアンドプレースヘッド
US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
HUE054529T2 (hu) * 2014-03-11 2021-09-28 Molecular Templates Inc Amino-terminális proximális Shiga toxin A alegység effektor régiókat és sejtcélzó immunglobulin-típusú kötõrégiókat tartalmazó proteinek, amelyek képesek CD38 specifikus kötésére
ES2864124T3 (es) * 2014-03-11 2021-10-13 Molecular Templates Inc Proteínas que comprenden regiones de unión, regiones efectoras de la subunidad A de toxina Shiga y motivos señal de localización de retículo endoplasmático carboxi terminal
ES2717751T3 (es) 2014-06-11 2019-06-25 Molecular Templates Inc Polipéptidos efectores de la subunidad A de la toxina de Shiga resistentes a la escisión por proteasa y moléculas dirigidas a células que los comprenden
US10392425B2 (en) 2015-02-05 2019-08-27 Molecular Templates, Inc. Multivalent CD20-binding molecules comprising Shiga toxin A subunit effector regions and enriched compositions thereof
RS60441B1 (sr) 2015-05-30 2020-07-31 Molecular Templates Inc De-imunizovane, strukture shiga toksin a podjedinice i ciljani ćelijski molekuli koji sadrže isti
EP3325510A2 (de) * 2015-07-26 2018-05-30 Molecular Templates, Inc. Gegen zellen gerichtete moleküle mit effektoren der shigatoxin-a-untereinheit und cd8+-t-zellepitopen
IL302130A (en) 2016-12-07 2023-06-01 Molecular Templates Inc Shiga toxin A subunit activator polypeptides, Shiga toxin activator scaffolds and cell-targeting molecules for site-specific conjugation
US10454114B2 (en) 2016-12-22 2019-10-22 The Research Foundation For The State University Of New York Method of producing stable, active and mass-producible Pt3Ni catalysts through preferential co etching
KR102590672B1 (ko) 2017-01-25 2023-10-18 몰레큘러 템플레이츠, 인코퍼레이션. 탈면역된 시가 독소 a 서브유닛 이펙터 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자
WO2019204272A1 (en) 2018-04-17 2019-10-24 Molecular Templates, Inc. Her2-targeting molecules comprising de-immunized, shiga toxin a subunit scaffolds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552144A (en) * 1992-01-22 1996-09-03 Microcarb, Inc. Immunogenic shiga-like toxin II variant mutants
US5968894A (en) * 1994-02-22 1999-10-19 Lingwood; Clifford A. Verotoxin pharmaceutical compositions and medical treatments therewith
CA2116179C (en) 1994-02-22 2008-01-08 C. A. Lingwood Verotoxin pharmaceutical compositions and medical treatments therewith
US5837680A (en) * 1996-02-16 1998-11-17 Children's Medical Center Corporation Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis
WO1998051326A1 (en) * 1997-05-16 1998-11-19 Hsc Research And Development Limited Partnership Inhibition of angiogenesis by verotoxins

Also Published As

Publication number Publication date
EP1496116A4 (de) 2005-08-24
EP1496116B1 (de) 2010-06-16
US20100047285A1 (en) 2010-02-25
WO2003066854A1 (fr) 2003-08-14
US20070154485A1 (en) 2007-07-05
AU2003208097A1 (en) 2003-09-02
ATE471371T1 (de) 2010-07-15
JPWO2003066854A1 (ja) 2005-06-02
US20050163807A1 (en) 2005-07-28
HK1073130A1 (en) 2005-09-23
EP1496116A1 (de) 2005-01-12
JP4214397B2 (ja) 2009-01-28

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