DE602004027168D1 - Bibliothek von toxin mutanten und deren verwendung - Google Patents

Bibliothek von toxin mutanten und deren verwendung

Info

Publication number
DE602004027168D1
DE602004027168D1 DE602004027168T DE602004027168T DE602004027168D1 DE 602004027168 D1 DE602004027168 D1 DE 602004027168D1 DE 602004027168 T DE602004027168 T DE 602004027168T DE 602004027168 T DE602004027168 T DE 602004027168T DE 602004027168 D1 DE602004027168 D1 DE 602004027168D1
Authority
DE
Germany
Prior art keywords
library
toxin mutants
mutants
toxin
libraries
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004027168T
Other languages
English (en)
Inventor
Jean Gariepy
Xin Wei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Templates Inc
Original Assignee
Molecular Templates Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Templates Inc filed Critical Molecular Templates Inc
Publication of DE602004027168D1 publication Critical patent/DE602004027168D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/25—Shigella (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE602004027168T 2004-03-26 2004-03-26 Bibliothek von toxin mutanten und deren verwendung Expired - Lifetime DE602004027168D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CA2004/000443 WO2005092917A1 (en) 2004-03-26 2004-03-26 Library of toxin mutants, and methods of using same

Publications (1)

Publication Number Publication Date
DE602004027168D1 true DE602004027168D1 (de) 2010-06-24

Family

ID=34957323

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004027168T Expired - Lifetime DE602004027168D1 (de) 2004-03-26 2004-03-26 Bibliothek von toxin mutanten und deren verwendung

Country Status (9)

Country Link
US (1) US20070298434A1 (de)
EP (2) EP1727827B1 (de)
JP (1) JP4934761B2 (de)
AT (1) ATE467641T1 (de)
AU (1) AU2004317555B2 (de)
CA (1) CA2559536A1 (de)
DE (1) DE602004027168D1 (de)
ES (2) ES2386338T3 (de)
WO (1) WO2005092917A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2402367A1 (de) * 2005-09-26 2012-01-04 Molecular Templates, Inc. Bibliothek aus Toxinmutanten und Verwendungsverfahren dafür
JP2009520468A (ja) * 2005-12-23 2009-05-28 ヴィヴェンティア バイオテック インコーポレーティッド 融合タンパク質ライブラリーの作製法およびスクリーニング法、ならびにそれらの使用
CN105051067B (zh) 2013-03-12 2020-04-17 分子模板公司 用于引起细胞内化的cd20结合免疫毒素及其使用方法
KR102514910B1 (ko) 2014-01-27 2023-03-29 몰레큘러 템플레이츠, 인코퍼레이션. 폴리펩티드를 전달하는 mhc 클래스 i 항원결정기
US10421958B2 (en) 2014-02-05 2019-09-24 Molecular Templates, Inc. Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
EP3137488B1 (de) 2014-06-11 2019-01-02 Molecular Templates, Inc. Proteasespaltungsbeständige shigatoxin-a-untereinheiteffektorpolypeptide und zellgerichtete moleküle damit
AU2016215205B2 (en) 2015-02-05 2021-10-21 Molecular Templates, Inc. Multivalent CD20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof
EP3303373B1 (de) 2015-05-30 2020-04-08 Molecular Templates, Inc. Deimmunisierte shigatoxin-a-untereinheitsgerüste und zellgerichtete moleküle damit
CN107922493A (zh) 2015-07-26 2018-04-17 分子模板公司 包含志贺毒素a亚基效应物和cd8+ t‑细胞表位的细胞靶向分子
US20210008208A1 (en) 2016-12-07 2021-01-14 Molecular Templates, Inc. Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation
CN110536695B (zh) 2017-01-25 2024-05-10 分子模板公司 包括去免疫化的志贺毒素a亚基效应子和cd8+ t细胞表位的细胞靶向分子
EP3573652A1 (de) 2018-04-17 2019-12-04 Molecular Templates, Inc. Gegen her2 gerichtete moleküle mit deimmunisierten shiga-toxin-a-subeinheitsgerüsten
WO2020081493A1 (en) 2018-10-16 2020-04-23 Molecular Templates, Inc. Pd-l1 binding proteins
WO2021055816A1 (en) 2019-09-18 2021-03-25 Molecular Templates, Inc. Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds
JP2022548078A (ja) 2019-09-18 2022-11-16 モレキュラー テンプレーツ，インク． 志賀毒素ａサブユニット足場を含むｐｄ－ｌ１結合分子
US20210155671A1 (en) 2019-11-24 2021-05-27 Molecular Templates, Inc. Uses of cd20-binding molecules and additional therapeutic agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5621083A (en) 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US5552144A (en) * 1992-01-22 1996-09-03 Microcarb, Inc. Immunogenic shiga-like toxin II variant mutants
JPH11506424A (ja) * 1995-03-24 1999-06-08 オフィディアン ファーマシューティカルズ インコーポレーテッド ベロ毒素産生大腸菌に対する治療
ATE437229T1 (de) 1997-04-30 2009-08-15 Twinstrand Therapeutics Inc Ricin-ähnliche toxine zur therapie von kreb, viraler oder parasitärer infektionen
US7314632B1 (en) * 1997-07-11 2008-01-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pseudomonas exotoxin A-like chimeric immunogens
CA2222993A1 (en) * 1998-02-04 1999-08-04 The Ontario Cancer Institute A method for using a ribosome-inactivating protein complex as a structural template and a molecular search engine in the design, construction and screening of combinatorial protein libraries
AU2001238501A1 (en) * 2000-02-16 2001-08-27 Bechtel Bwxt Idaho, Llc Selective destruction of cells infected with human immunodeficiency virus
EP1263776A2 (de) * 2000-03-16 2002-12-11 University Of Pittsburgh Peptide, die spezifisch die endothelzellen aus tumoren markieren
EP2402367A1 (de) * 2005-09-26 2012-01-04 Molecular Templates, Inc. Bibliothek aus Toxinmutanten und Verwendungsverfahren dafür

Also Published As

Publication number Publication date
AU2004317555A1 (en) 2005-10-06
ES2344844T3 (es) 2010-09-08
JP4934761B2 (ja) 2012-05-16
JP2007531716A (ja) 2007-11-08
EP1727827A1 (de) 2006-12-06
US20070298434A1 (en) 2007-12-27
EP1727827B1 (de) 2010-05-12
AU2004317555B2 (en) 2011-12-01
ES2386338T3 (es) 2012-08-17
EP2228383A1 (de) 2010-09-15
ATE467641T1 (de) 2010-05-15
CA2559536A1 (en) 2005-10-06
WO2005092917A1 (en) 2005-10-06
EP2228383B1 (de) 2012-05-23

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