DK3269736T3 - Konformationsspecifikke antistoffer mod oligomerer af amyloid beta - Google Patents

Konformationsspecifikke antistoffer mod oligomerer af amyloid beta Download PDF

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Publication number
DK3269736T3
DK3269736T3 DK17185247.8T DK17185247T DK3269736T3 DK 3269736 T3 DK3269736 T3 DK 3269736T3 DK 17185247 T DK17185247 T DK 17185247T DK 3269736 T3 DK3269736 T3 DK 3269736T3
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DK
Denmark
Prior art keywords
oigomers
conformity
antibodies against
specific antibodies
amyloid beta
Prior art date
Application number
DK17185247.8T
Other languages
English (en)
Inventor
Thomas Bayer
Original Assignee
Georg August Univ Goettingen Stiftung Oeffentlichen Rechts Univsmedizin
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Application filed by Georg August Univ Goettingen Stiftung Oeffentlichen Rechts Univsmedizin filed Critical Georg August Univ Goettingen Stiftung Oeffentlichen Rechts Univsmedizin
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Publication of DK3269736T3 publication Critical patent/DK3269736T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK17185247.8T 2012-05-10 2013-05-08 Konformationsspecifikke antistoffer mod oligomerer af amyloid beta DK3269736T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12167565 2012-05-10
EP13724769.8A EP2847217B1 (en) 2012-05-10 2013-05-08 CONFORMATIONAL-SPECIFIC ANTIBODIES AGAINST OLIGOMERS of Amyloid beta

Publications (1)

Publication Number Publication Date
DK3269736T3 true DK3269736T3 (da) 2020-01-13

Family

ID=48485135

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17185247.8T DK3269736T3 (da) 2012-05-10 2013-05-08 Konformationsspecifikke antistoffer mod oligomerer af amyloid beta

Country Status (5)

Country Link
US (1) US9617332B2 (da)
EP (2) EP2847217B1 (da)
DK (1) DK3269736T3 (da)
HK (2) HK1207869A1 (da)
WO (1) WO2013167681A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107531781B (zh) * 2015-01-29 2021-12-07 抗菌技术,生物技术研究与发展股份有限公司 用于阿尔茨海默病和相关紊乱的抗体分子和肽递送系统
GB2541003A (en) * 2015-08-05 2017-02-08 Kran Life Sciences Llp Neurodegenerative disorders
US10870709B2 (en) 2016-07-22 2020-12-22 New York University Specific murine and humanized monoclonal antibodies detecting pathology associated secondary structure changes in proteins and peptides
KR20210080400A (ko) * 2018-10-04 2021-06-30 게오르그-아우구스트-우니베시태트 괴팅겐 스티프퉁 외펜틀리헨 레흐츠, 우니베시태츠메디진 인간화 항-n-절단 아밀로이드 베타 단일 클론 항체
CA3167073A1 (en) 2020-03-10 2021-09-16 Preeti BAKRANIA Cyclic peptides
CN112816533A (zh) * 2020-12-31 2021-05-18 商丘师范学院 一种铜纳米簇作为电化学信号探针的β-淀粉样蛋白寡聚体传感器
CN117586388A (zh) * 2022-08-09 2024-02-23 深圳智源生物医药有限公司 改进的β淀粉样蛋白寡聚体特异性结合抗体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPWO2005105998A1 (ja) 2004-04-27 2008-07-31 財団法人化学及血清療法研究所 ヒト抗アミロイドβペプチド抗体およびその抗体フラグメント
AU2008312802A1 (en) 2007-10-19 2009-04-23 Immunas Pharma, Inc. Antibody capable of specifically binding to abeta oligomer, and use thereof
EP2205633A1 (en) 2007-10-29 2010-07-14 Innogenetics N.V. New antibodies specific of the -amyloid peptides and their uses as diagnostic agents or drugs
NZ583632A (en) * 2007-11-16 2012-05-25 Univ Rockefeller Antibodies specific for the protofibril form of beta-amyloid protein
CA2714413C (en) 2008-02-08 2017-01-24 Immunas Pharma, Inc. Antibody capable of binding specifically to ab-oligomer, and use thereof
US8795664B2 (en) 2010-06-04 2014-08-05 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Monoclonal antibodies targeting amyloid beta oligomers

Also Published As

Publication number Publication date
EP3269736B1 (en) 2019-11-27
US20150118239A1 (en) 2015-04-30
HK1249116A1 (zh) 2018-10-26
HK1207869A1 (en) 2016-02-12
EP2847217A1 (en) 2015-03-18
EP2847217B1 (en) 2017-10-11
WO2013167681A8 (en) 2014-03-06
EP3269736A1 (en) 2018-01-17
WO2013167681A1 (en) 2013-11-14
US9617332B2 (en) 2017-04-11

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