JP2012100675A5 - - Google Patents
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- Publication number
- JP2012100675A5 JP2012100675A5 JP2011290406A JP2011290406A JP2012100675A5 JP 2012100675 A5 JP2012100675 A5 JP 2012100675A5 JP 2011290406 A JP2011290406 A JP 2011290406A JP 2011290406 A JP2011290406 A JP 2011290406A JP 2012100675 A5 JP2012100675 A5 JP 2012100675A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- present
- further embodiment
- pharmaceutical composition
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67418505P | 2005-04-22 | 2005-04-22 | |
| US60/674,185 | 2005-04-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008508006A Division JP2009521206A (ja) | 2005-04-22 | 2006-04-24 | 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012100675A JP2012100675A (ja) | 2012-05-31 |
| JP2012100675A5 true JP2012100675A5 (enExample) | 2013-03-21 |
Family
ID=37215502
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008508006A Pending JP2009521206A (ja) | 2005-04-22 | 2006-04-24 | 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 |
| JP2011290406A Pending JP2012100675A (ja) | 2005-04-22 | 2011-12-29 | 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008508006A Pending JP2009521206A (ja) | 2005-04-22 | 2006-04-24 | 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US20060239910A1 (enExample) |
| EP (2) | EP2172487A1 (enExample) |
| JP (2) | JP2009521206A (enExample) |
| AU (1) | AU2006241099B2 (enExample) |
| CA (1) | CA2607444C (enExample) |
| WO (1) | WO2006116592A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007537709A (ja) * | 2003-05-23 | 2007-12-27 | モーフオテク・インコーポレーテツド | 腫瘍抗原を特異的に結合するモノクローナル抗体 |
| EP1648511A1 (en) * | 2003-07-29 | 2006-04-26 | Morphotek, Inc. | Antibodies and methods for generating genetically altered antibodies with enhanced effector function |
| EP1716179A2 (en) * | 2004-02-12 | 2006-11-02 | Morphotek, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
| EP2322560B1 (en) * | 2005-03-10 | 2013-09-04 | Morphotek, Inc. | Anti-mesothelin antibodies |
| JP2009521206A (ja) | 2005-04-22 | 2009-06-04 | モルフォテック、インク. | 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 |
| US20090191202A1 (en) * | 2005-09-29 | 2009-07-30 | Jamieson Catriona Helen M | Methods for manipulating phagocytosis mediated by CD47 |
| US11072655B2 (en) | 2008-01-15 | 2021-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Markers of acute myeloid leukemia stem cells |
| CA3108119C (en) | 2008-01-15 | 2024-01-16 | The Board Of Trustees Of The Leland Stanford Junior University | Markers of acute myeloid leukemia stem cells |
| PT2242512T (pt) | 2008-01-15 | 2016-07-18 | Univ Leland Stanford Junior | Métodos para manipular a fagocitose mediada por cd47 |
| AU2014203172B2 (en) * | 2010-02-24 | 2016-03-10 | Immunogen, Inc. | Folate Receptor 1 Antibodies and Immunoconjugates and Uses Thereof |
| AR080301A1 (es) | 2010-02-24 | 2012-03-28 | Immunogen Inc | Anticuerpos e inmunoconjugados del receptor 1 de folato y sus usos |
| EP4349868A3 (en) | 2010-05-14 | 2024-08-28 | The Board of Trustees of the Leland Stanford Junior University | Humanized and chimeric monoclonal antibodies to cd47 |
| US20120164137A1 (en) * | 2010-10-20 | 2012-06-28 | Morphotek, Inc. | Anti-folate receptor alpha antibody glycoforms |
| US20120207771A1 (en) * | 2010-11-05 | 2012-08-16 | Morphotek Inc. | Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers |
| US9402865B2 (en) | 2011-01-18 | 2016-08-02 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating cancer |
| EP2687231A4 (en) | 2011-03-18 | 2014-10-22 | Univ Kagoshima | COMPOSITION FOR THE TREATMENT AND DIAGNOSIS OF PANCREATIC CANCER |
| PL2694106T3 (pl) * | 2011-04-01 | 2018-06-29 | Immunogen, Inc. | Sposoby zwiększania skuteczności terapii przeciwnowotworowej opartej na receptorze folr1 |
| AU2012284321C1 (en) | 2011-07-15 | 2017-07-13 | Eisai R&D Management Co., Ltd. | Anti-folate receptor alpha antibodies and uses thereof |
| KR20150046316A (ko) * | 2012-08-31 | 2015-04-29 | 이뮤노젠 아이엔씨 | 엽산 수용체 1의 검출을 위한 진단성 검정 및 키트 |
| WO2014055771A1 (en) | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Human alpha-folate receptor chimeric antigen receptor |
| CA2893378A1 (en) * | 2012-12-07 | 2014-06-12 | Kyowa Hakko Kirin Co., Ltd. | Anti-folr1 antibody |
| WO2014205342A2 (en) | 2013-06-20 | 2014-12-24 | Morphotek, Inc. | Methods for treatment of ovarian cancer |
| PT3038650T (pt) | 2013-08-30 | 2021-08-25 | Immunogen Inc | Anticorpos e ensaios para a deteção do recetor de folato 1 |
| FI4141032T3 (fi) | 2014-11-20 | 2024-07-31 | Hoffmann La Roche | T-solua aktivoivien bispesifisten antigeeniä sitovien molekyylien ja pd-1-akselia sitovien antagonistien yhdistelmähoito |
| BR112017010513A2 (pt) | 2014-11-20 | 2018-04-03 | F. Hoffmann-La Roche Ag | ?cadeias leves comuns e métodos de uso? |
| EP3221356B1 (en) | 2014-11-20 | 2020-09-02 | F.Hoffmann-La Roche Ag | T cell activating bispecific antigen binding molecules against folr1 and cd3 |
| AU2016248222A1 (en) | 2015-04-17 | 2017-11-09 | Eisai, Inc. | Methods for treating lung cancer |
| JP6880006B2 (ja) | 2015-09-17 | 2021-06-02 | イミュノジェン, インコーポレイテッド | 抗folr1免疫複合体を含む治療組み合わせ |
| HK1257309A1 (zh) | 2015-09-21 | 2019-10-18 | Erasmus University Medical Center | 抗-cd47抗体及使用方法 |
| CN115925952A (zh) | 2018-03-13 | 2023-04-07 | 东莞凡恩世生物医药有限公司 | 抗叶酸受体1抗体及其用途 |
| KR102275930B1 (ko) | 2018-03-14 | 2021-07-12 | (주)알테오젠 | Folr1에 특이적으로 결합하는 항체 및 그의 용도 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020129838A1 (ja) * | 2018-12-17 | 2020-06-25 | 株式会社カネカ | 特定抗原特異的抗体を産生する細胞のスクリーニング方法 |
| CN114222756A (zh) | 2019-04-29 | 2022-03-22 | 伊缪诺金公司 | 双互补位FR-α抗体和免疫缀合物 |
| CN118047871A (zh) * | 2022-11-16 | 2024-05-17 | 迈威(上海)生物科技股份有限公司 | 一种靶向FRα的抗体或其抗原结合片段及其应用 |
| US12624097B2 (en) | 2023-07-03 | 2026-05-12 | Medicovestor, Inc. | Nucleic acids, vectors, and cells that encode anti-Sp17 antibodies and other Sp17 binding proteins |
| US12600795B2 (en) | 2023-12-26 | 2026-04-14 | Medicovestor, Inc. | Oligomeric IgG for immunotherapeutics and diagnostics |
| US12121587B1 (en) | 2023-12-26 | 2024-10-22 | Medicovestor, Inc. | Dimeric antibodies |
| US12378314B1 (en) * | 2024-02-02 | 2025-08-05 | Medicovestor, Inc. | Proteins that bind folate receptor alpha including fully-human antibodies |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4694778A (en) * | 1984-05-04 | 1987-09-22 | Anicon, Inc. | Chemical vapor deposition wafer boat |
| US4851332A (en) * | 1985-04-01 | 1989-07-25 | Sloan-Kettering Institute For Cancer Research | Choriocarcinoma monoclonal antibodies and antibody panels |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5006470A (en) | 1987-04-16 | 1991-04-09 | Sloan-Kettering Institute For Cancer Research | Human monoclonal antibodies to cell surface antigens of melanoma |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5688488A (en) | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| CA2093928C (en) * | 1990-10-12 | 2000-02-29 | Mark C. Willingham | Monoclonal antibodies for detection and treatment of cancer |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5646253A (en) | 1994-03-08 | 1997-07-08 | Memorial Sloan-Kettering Cancer Center | Recombinant human anti-LK26 antibodies |
| US6191268B1 (en) * | 1993-12-17 | 2001-02-20 | Dana-Farber Cancer Institute | Compositions and methods relating to DNA mismatch repair genes |
| NZ281023A (en) * | 1994-01-27 | 1998-04-27 | Human Genome Sciences Inc | Human dna mismatch repair proteins and coding sequences |
| DE19513676A1 (de) * | 1995-04-11 | 1996-10-17 | Behringwerke Ag | Cytoplasmatische Expression von Antikörpern, Antikörperfragmenten und Antikörperfragmentfusionsmolekülen in E.coli |
| DE19541844C1 (de) | 1995-11-09 | 1997-07-24 | Gsf Forschungszentrum Umwelt | Verfahren zur Herstellung von menschlichen Antikörpern und deren Verwendung |
| JP2000505787A (ja) | 1996-01-05 | 2000-05-16 | アメリカ合衆国 | 中皮抗原及びそれを標的化するための方法及びキット |
| WO1997042329A1 (en) | 1996-05-04 | 1997-11-13 | Zeneca Limited | Monoclonal antibody to cea, conjugates comprising said antibody, and their therapeutic use in an adept system |
| US6809184B1 (en) * | 1997-12-01 | 2004-10-26 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use |
| US6146894A (en) | 1998-04-14 | 2000-11-14 | The Johns Hopkins University | Method for generating hypermutable organisms |
| US6365410B1 (en) * | 1999-05-19 | 2002-04-02 | Genencor International, Inc. | Directed evolution of microorganisms |
| DE60039510D1 (de) | 1999-05-27 | 2008-08-28 | Us Gov Health & Human Serv | Immunokonjugate mit hoher bindungsaffinität |
| US6808894B1 (en) * | 2000-11-07 | 2004-10-26 | Morphotek, Inc. | Methods for generating genetically altered antibody producing cell lines with improved antibody characteristics |
| ATE423467T1 (de) | 2000-11-07 | 2009-03-15 | Morphotek Inc | Verfahren zur herstellung von genetisch modifizierten antikörperproduzierenden zelllinien mit verbesserten antikörpereigenschaften |
| DE60144247D1 (de) | 2001-01-15 | 2011-04-28 | Morphotek Inc | Chemische hemmstoffe des mismatch-repair |
| PL367102A1 (en) | 2001-05-02 | 2005-02-21 | Purdue Research Foundation | Treatment and diagnosis of macrophage mediated disease |
| PL365735A1 (en) | 2001-05-18 | 2005-01-10 | Boehringer Ingelheim International Gmbh | Antibodies specific for cd44v6 |
| EP1258255A1 (en) | 2001-05-18 | 2002-11-20 | Boehringer Ingelheim International GmbH | Conjugates of an antibody to CD44 and a maytansinoid |
| AU2003222185A1 (en) | 2002-04-01 | 2003-10-20 | Utah Ventures Ii, L.P. | Tissue-specific endothelial membrane proteins |
| JP4527531B2 (ja) | 2002-07-19 | 2010-08-18 | モーフオテク・インコーポレーテツド | 改良された増殖の特徴を伴う高められた抗体産生細胞株の生成方法 |
| JP2007537709A (ja) * | 2003-05-23 | 2007-12-27 | モーフオテク・インコーポレーテツド | 腫瘍抗原を特異的に結合するモノクローナル抗体 |
| EP1648511A1 (en) | 2003-07-29 | 2006-04-26 | Morphotek, Inc. | Antibodies and methods for generating genetically altered antibodies with enhanced effector function |
| WO2005014652A1 (en) | 2003-08-05 | 2005-02-17 | Morphotek, Inc. | A variant cell surface molecule associated with cancer |
| EP1716179A2 (en) | 2004-02-12 | 2006-11-02 | Morphotek, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
| CA2582194A1 (en) | 2004-10-05 | 2006-04-20 | Neuralab Limited | Methods and compositions for improving recombinant protein production |
| EP2322560B1 (en) * | 2005-03-10 | 2013-09-04 | Morphotek, Inc. | Anti-mesothelin antibodies |
| WO2006105141A1 (en) | 2005-03-30 | 2006-10-05 | Purdue Research Foundation | Method for cancer prognosis using cellular folate vitamin receptor quantification |
| JP2009521206A (ja) | 2005-04-22 | 2009-06-04 | モルフォテック、インク. | 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 |
| EP1940473A2 (en) | 2005-09-23 | 2008-07-09 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
| US20080312093A1 (en) | 2005-11-04 | 2008-12-18 | Johji Inazawa | Method for detecting cancer and a method for suppressing cancer |
| EP1900752A1 (en) | 2006-09-15 | 2008-03-19 | DOMPE' pha.r.ma s.p.a. | Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma |
| US8685752B2 (en) | 2006-11-03 | 2014-04-01 | Purdue Research Foundation | Ex vivo flow cytometry method and device |
| CN104383553A (zh) | 2007-06-25 | 2015-03-04 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| WO2009032974A2 (en) | 2007-09-06 | 2009-03-12 | Tripath Imaging, Inc. | Nucleic acid-based methods for the detection of ovarian cancer |
| GB0725077D0 (en) | 2007-12-21 | 2008-01-30 | Univ Murcia | Antifolate com[ounds for the treatment of melanoma |
| WO2009132081A2 (en) | 2008-04-24 | 2009-10-29 | The Research Foundation Of State University Of New York | Monoclonal antibody-based targeting of folate receptors |
| US20120164137A1 (en) * | 2010-10-20 | 2012-06-28 | Morphotek, Inc. | Anti-folate receptor alpha antibody glycoforms |
| US20120207771A1 (en) * | 2010-11-05 | 2012-08-16 | Morphotek Inc. | Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers |
| WO2013172951A1 (en) * | 2012-05-15 | 2013-11-21 | Morphotek, Inc. | Methods for treatment of gastric cancer |
| CA2893378A1 (en) * | 2012-12-07 | 2014-06-12 | Kyowa Hakko Kirin Co., Ltd. | Anti-folr1 antibody |
| WO2014205342A2 (en) * | 2013-06-20 | 2014-12-24 | Morphotek, Inc. | Methods for treatment of ovarian cancer |
| AU2016248222A1 (en) * | 2015-04-17 | 2017-11-09 | Eisai, Inc. | Methods for treating lung cancer |
| MA45280B1 (fr) * | 2016-03-02 | 2021-08-31 | Eisai R&D Man Co Ltd | Conjugués anticorps-médicament à base d'éribuline et leurs procédés d'utilisation |
-
2006
- 2006-04-24 JP JP2008508006A patent/JP2009521206A/ja active Pending
- 2006-04-24 WO PCT/US2006/016004 patent/WO2006116592A2/en not_active Ceased
- 2006-04-24 CA CA2607444A patent/CA2607444C/en not_active Expired - Lifetime
- 2006-04-24 EP EP20090176155 patent/EP2172487A1/en not_active Withdrawn
- 2006-04-24 EP EP06758662A patent/EP1879922A2/en not_active Withdrawn
- 2006-04-24 US US11/410,442 patent/US20060239910A1/en not_active Abandoned
- 2006-04-24 AU AU2006241099A patent/AU2006241099B2/en not_active Expired
-
2009
- 2009-07-16 US US12/503,983 patent/US8124083B2/en active Active
-
2011
- 2011-12-29 JP JP2011290406A patent/JP2012100675A/ja active Pending
-
2012
- 2012-01-24 US US13/356,724 patent/US9144614B2/en active Active
-
2015
- 2015-07-27 US US14/809,887 patent/US9522195B2/en not_active Expired - Lifetime
-
2016
- 2016-11-08 US US15/346,332 patent/US10253106B2/en active Active
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