JP2012100675A5 - - Google Patents

Download PDF

Info

Publication number
JP2012100675A5
JP2012100675A5 JP2011290406A JP2011290406A JP2012100675A5 JP 2012100675 A5 JP2012100675 A5 JP 2012100675A5 JP 2011290406 A JP2011290406 A JP 2011290406A JP 2011290406 A JP2011290406 A JP 2011290406A JP 2012100675 A5 JP2012100675 A5 JP 2012100675A5
Authority
JP
Japan
Prior art keywords
antibody
present
further embodiment
pharmaceutical composition
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011290406A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012100675A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2012100675A publication Critical patent/JP2012100675A/ja
Publication of JP2012100675A5 publication Critical patent/JP2012100675A5/ja
Pending legal-status Critical Current

Links

JP2011290406A 2005-04-22 2011-12-29 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体 Pending JP2012100675A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67418505P 2005-04-22 2005-04-22
US60/674,185 2005-04-22

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2008508006A Division JP2009521206A (ja) 2005-04-22 2006-04-24 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体

Publications (2)

Publication Number Publication Date
JP2012100675A JP2012100675A (ja) 2012-05-31
JP2012100675A5 true JP2012100675A5 (enExample) 2013-03-21

Family

ID=37215502

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008508006A Pending JP2009521206A (ja) 2005-04-22 2006-04-24 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体
JP2011290406A Pending JP2012100675A (ja) 2005-04-22 2011-12-29 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2008508006A Pending JP2009521206A (ja) 2005-04-22 2006-04-24 免疫エフェクター活性を有する葉酸受容体アルファ陽性細胞に内部移行する抗体

Country Status (6)

Country Link
US (5) US20060239910A1 (enExample)
EP (2) EP2172487A1 (enExample)
JP (2) JP2009521206A (enExample)
AU (1) AU2006241099B2 (enExample)
CA (1) CA2607444C (enExample)
WO (1) WO2006116592A2 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1626991A2 (en) * 2003-05-23 2006-02-22 Morphotek, Inc. Anti alpha-folate-receptor-tetramer antibodies
US20050054048A1 (en) * 2003-07-29 2005-03-10 Luigi Grasso Antibodies and methods for generating genetically altered antibodies with enhanced effector function
CA2556027C (en) 2004-02-12 2015-11-24 Morphotek, Inc. Monoclonal antibodies that specifically block biological activity of a tumor antigen
EP2322560B1 (en) 2005-03-10 2013-09-04 Morphotek, Inc. Anti-mesothelin antibodies
EP2172487A1 (en) 2005-04-22 2010-04-07 Morphotek Inc. Antibodies with Immune Effector Activity that Internalize in Folate Receptor Alpha-Positive Cells
US20090191202A1 (en) * 2005-09-29 2009-07-30 Jamieson Catriona Helen M Methods for manipulating phagocytosis mediated by CD47
PT3056515T (pt) * 2008-01-15 2019-07-19 Univ Leland Stanford Junior Métodos para manipulação da fagocitose mediada por cd47
US11072655B2 (en) 2008-01-15 2021-07-27 The Board Of Trustees Of The Leland Stanford Junior University Markers of acute myeloid leukemia stem cells
CA2711370C (en) 2008-01-15 2017-06-13 The Board Of Trustees Of The Leland Stanford Junior University Markers of acute myeloid leukemia stem cells
AU2014203172B2 (en) * 2010-02-24 2016-03-10 Immunogen, Inc. Folate Receptor 1 Antibodies and Immunoconjugates and Uses Thereof
CN105777907B (zh) * 2010-02-24 2020-03-17 伊缪诺金公司 叶酸受体1抗体与免疫缀合物以及其用途
AU2011252851B2 (en) 2010-05-14 2016-10-06 The Board Of Trustees Of The Leland Stanford Junior University Humanized and chimeric monoclonal antibodies to CD47
KR20140032944A (ko) * 2010-10-20 2014-03-17 모르포테크, 인크. 항폴레이트 수용체 알파 항체 당형태
SG189957A1 (en) * 2010-11-05 2013-06-28 Morphotek Inc Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers
JP2014509841A (ja) 2011-01-18 2014-04-24 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 癌を治療するための組成物および方法
JP5881085B2 (ja) 2011-03-18 2016-03-09 国立大学法人 鹿児島大学 膵臓癌の治療用及び診断用の組成物
ES2661466T3 (es) * 2011-04-01 2018-04-02 Immunogen, Inc. Métodos para aumentar la eficacia de la terapia contra el cáncer con FOLR1
CN107011439B (zh) * 2011-07-15 2020-11-10 卫材R&D管理有限公司 抗叶酸受体α抗体及其应用
SG11201500938XA (en) * 2012-08-31 2015-04-29 Immunogen Inc Diagnostic assays and kits for detection of folate receptor 1
US9598489B2 (en) 2012-10-05 2017-03-21 The Trustees Of The Univeristy Of Pennsylvania Human alpha-folate receptor chimeric antigen receptor
CN104884617B (zh) 2012-12-07 2019-02-19 协和发酵麒麟株式会社 抗folr1抗体
BR112015031950A2 (pt) 2013-06-20 2017-07-25 Morphotek Inc métodos para tratamento de câncer de ovário
NZ717140A (en) 2013-08-30 2022-05-27 Immunogen Inc Antibodies and assays for detection of folate receptor 1
SG11201704056XA (en) 2014-11-20 2017-06-29 Hoffmann La Roche Combination therapy of t cell activating bispecific antigen binding molecules cd3 abd folate receptor 1 (folr1) and pd-1 axis binding antagonists
RS61010B1 (sr) 2014-11-20 2020-11-30 Hoffmann La Roche Bispecifični antigen vezujući molekuli koji aktiviraju t ćelije protiv folr1 i cd3
ES2808853T3 (es) 2014-11-20 2021-03-02 Hoffmann La Roche Cadenas ligeras comunes y procedimientos de uso
CA2983126A1 (en) * 2015-04-17 2016-10-20 Morphotek, Inc. Methods for treating lung cancer
CN122075735A (zh) 2015-09-17 2026-05-26 伊缪诺金公司 包含抗folr1免疫缀合物的治疗组合
US9650441B2 (en) 2015-09-21 2017-05-16 Erasmus University Medical Center Anti-CD47 antibodies and methods of use
EP3765521A4 (en) 2018-03-13 2022-03-23 Phanes Therapeutics, Inc. ANTI-FOLATE RECEPTOR-1 ANTIBODIES AND USES THEREOF
KR102275930B1 (ko) * 2018-03-14 2021-07-12 (주)알테오젠 Folr1에 특이적으로 결합하는 항체 및 그의 용도
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
JP7426661B2 (ja) * 2018-12-17 2024-02-02 株式会社カネカ 特定抗原特異的抗体を産生する細胞のスクリーニング方法
SG11202111109UA (en) 2019-04-29 2021-11-29 Immunogen Inc Biparatopic fr-alpha antibodies and immunoconjugates
WO2024104431A1 (zh) * 2022-11-16 2024-05-23 迈威(上海)生物科技股份有限公司 一种靶向FRα的抗体或其抗原结合片段及其应用
US12649790B2 (en) 2023-07-03 2026-06-09 Medicovestor, Inc. Proteins that bind SP17 including fully-human anti-SP17 antibodies
US12624097B2 (en) 2023-07-03 2026-05-12 Medicovestor, Inc. Nucleic acids, vectors, and cells that encode anti-Sp17 antibodies and other Sp17 binding proteins
US12673991B2 (en) 2023-12-26 2026-07-07 Medicovestor, Inc. Methods of crosslinking IgG
US12600795B2 (en) 2023-12-26 2026-04-14 Medicovestor, Inc. Oligomeric IgG for immunotherapeutics and diagnostics
US12121587B1 (en) 2023-12-26 2024-10-22 Medicovestor, Inc. Dimeric antibodies
US12378314B1 (en) 2024-02-02 2025-08-05 Medicovestor, Inc. Proteins that bind folate receptor alpha including fully-human antibodies

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4694778A (en) * 1984-05-04 1987-09-22 Anicon, Inc. Chemical vapor deposition wafer boat
US4851332A (en) 1985-04-01 1989-07-25 Sloan-Kettering Institute For Cancer Research Choriocarcinoma monoclonal antibodies and antibody panels
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5006470A (en) 1987-04-16 1991-04-09 Sloan-Kettering Institute For Cancer Research Human monoclonal antibodies to cell surface antigens of melanoma
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US5688488A (en) 1989-04-03 1997-11-18 Purdue Research Foundation Composition and method for tumor imaging
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
DK0554356T3 (da) * 1990-10-12 1999-06-14 Us Health Monoklonalt antistof
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US5646253A (en) * 1994-03-08 1997-07-08 Memorial Sloan-Kettering Cancer Center Recombinant human anti-LK26 antibodies
US6191268B1 (en) * 1993-12-17 2001-02-20 Dana-Farber Cancer Institute Compositions and methods relating to DNA mismatch repair genes
NZ281023A (en) * 1994-01-27 1998-04-27 Human Genome Sciences Inc Human dna mismatch repair proteins and coding sequences
DE19513676A1 (de) * 1995-04-11 1996-10-17 Behringwerke Ag Cytoplasmatische Expression von Antikörpern, Antikörperfragmenten und Antikörperfragmentfusionsmolekülen in E.coli
DE19541844C1 (de) 1995-11-09 1997-07-24 Gsf Forschungszentrum Umwelt Verfahren zur Herstellung von menschlichen Antikörpern und deren Verwendung
WO1997025068A2 (en) 1996-01-05 1997-07-17 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Mesothelin antigen and methods and kits for targeting it
BR9708910A (pt) 1996-05-04 1999-08-03 Zeneca Ltd Anticorpo conjugado sequência de polinucleotídeos vetor célula hospedeira hibridoma composição farmacêutica processos para fabricar um anticorpo ou um conjugado e para tratar um humano ou animal em necessidade deste tratamento
US6809184B1 (en) * 1997-12-01 2004-10-26 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use
US6146894A (en) 1998-04-14 2000-11-14 The Johns Hopkins University Method for generating hypermutable organisms
US6365410B1 (en) * 1999-05-19 2002-04-02 Genencor International, Inc. Directed evolution of microorganisms
MXPA01011950A (es) * 1999-05-27 2002-05-06 Gov Health & Human Serv Inmunoconjugados que tienen alta afinidad de enlace.
US6808894B1 (en) * 2000-11-07 2004-10-26 Morphotek, Inc. Methods for generating genetically altered antibody producing cell lines with improved antibody characteristics
DE60045652D1 (de) 2000-11-07 2011-03-31 Morphotek Inc Verfahren zur Erzeugung von genetisch veränderten Antikörperherstellungszelllinien mit verbesserter Antikörpereigenschaft
JP5036119B2 (ja) 2001-01-15 2012-09-26 モーフオテク・インコーポレーテツド ミスマッチ修復の化学阻害剤
IL158532A0 (en) 2001-05-02 2004-05-12 Purdue Research Foundation Treatment and diagnosis of macrophage mediated disease
EP1258255A1 (en) 2001-05-18 2002-11-20 Boehringer Ingelheim International GmbH Conjugates of an antibody to CD44 and a maytansinoid
EA200301169A1 (ru) 2001-05-18 2004-06-24 Бёрингер Ингельхайм Интернациональ Гмбх АНТИТЕЛА, СПЕЦИФИЧЕСКИЕ В ОТНОШЕНИИ CD44v6
GB2403222A (en) 2002-04-01 2004-12-29 Utah Ventures Ii L P Tissue-specific endothelial membrane proteins
AU2003256642B2 (en) 2002-07-19 2008-05-01 Morphotek, Inc. Methods for generating enhanced antibody-producing cell lines with improved growth characteristics
EP1626991A2 (en) * 2003-05-23 2006-02-22 Morphotek, Inc. Anti alpha-folate-receptor-tetramer antibodies
US20050054048A1 (en) 2003-07-29 2005-03-10 Luigi Grasso Antibodies and methods for generating genetically altered antibodies with enhanced effector function
CA2534659A1 (en) 2003-08-05 2005-02-17 Morphotek, Inc. A variant cell surface molecule associated with cancer
CA2556027C (en) * 2004-02-12 2015-11-24 Morphotek, Inc. Monoclonal antibodies that specifically block biological activity of a tumor antigen
EA200700751A1 (ru) 2004-10-05 2008-06-30 Элан Фарма Интернэшнл Лимитед Способы и композиции для улучшения продуцирования рекомбинантного белка
EP2322560B1 (en) * 2005-03-10 2013-09-04 Morphotek, Inc. Anti-mesothelin antibodies
DE602006012816D1 (de) 2005-03-30 2010-04-22 Endocyte Inc Tifizierung von zellulären folat vitamin rezeptoren
EP2172487A1 (en) 2005-04-22 2010-04-07 Morphotek Inc. Antibodies with Immune Effector Activity that Internalize in Folate Receptor Alpha-Positive Cells
US8795633B2 (en) 2005-09-23 2014-08-05 Purdue Research Foundation Multiphoton in vivo flow cytometry method and device
US20070154916A1 (en) 2005-11-04 2007-07-05 Johji Inazawa Method for detecting cancer and a method for suppressing cancer
EP1900752A1 (en) 2006-09-15 2008-03-19 DOMPE' pha.r.ma s.p.a. Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma
JP2010509570A (ja) 2006-11-03 2010-03-25 パーデュー・リサーチ・ファウンデーション エクスビボフローサイトメトリーの方法および装置
BRPI0812970A2 (pt) 2007-06-25 2019-09-24 Endocyte Inc conjugados contendo espaçadores hidrofílicos
WO2009032974A2 (en) 2007-09-06 2009-03-12 Tripath Imaging, Inc. Nucleic acid-based methods for the detection of ovarian cancer
GB0725077D0 (en) 2007-12-21 2008-01-30 Univ Murcia Antifolate com[ounds for the treatment of melanoma
WO2009132081A2 (en) 2008-04-24 2009-10-29 The Research Foundation Of State University Of New York Monoclonal antibody-based targeting of folate receptors
KR20140032944A (ko) * 2010-10-20 2014-03-17 모르포테크, 인크. 항폴레이트 수용체 알파 항체 당형태
SG189957A1 (en) * 2010-11-05 2013-06-28 Morphotek Inc Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers
JP6122948B2 (ja) * 2012-05-15 2017-04-26 モルフォテック, インコーポレイテッド 胃癌の治療のための方法
CN104884617B (zh) * 2012-12-07 2019-02-19 协和发酵麒麟株式会社 抗folr1抗体
BR112015031950A2 (pt) * 2013-06-20 2017-07-25 Morphotek Inc métodos para tratamento de câncer de ovário
CA2983126A1 (en) * 2015-04-17 2016-10-20 Morphotek, Inc. Methods for treating lung cancer
MY199595A (en) * 2016-03-02 2023-11-08 Eisai R&D Man Co Ltd Eribulin-based antibody-drug conjugates and methods of use

Similar Documents

Publication Publication Date Title
JP2012100676A5 (enExample)
JP2009521206A5 (enExample)
TWI853077B (zh) 新型抗cd39抗體
US10391155B2 (en) Peptidic chimeric antigen receptor T cell switches and uses thereof
DK2513146T3 (en) Antibodies against ROR1 capable of inducing cell death by CLL
US10106609B2 (en) CD7 nanobodies, encoding sequence and use thereof
JP6282745B2 (ja) 修飾抗上皮成長因子受容体抗体およびその使用法
HRP20170254T1 (hr) Humanizirana i kimerna monoklonska protutijela usmjerena na cd47
JP2017526339A5 (enExample)
JP2012521217A5 (enExample)
JP7800946B2 (ja) 抗tslpナノ抗体およびその使用
SA518391659B1 (ar) April جزيئات الأجسام المضادة لـ واستخداماتها
JP2020536109A5 (enExample)
EA017420B1 (ru) Антитела-нейтрализаторы гранулоцитарно-макрофагального колониестимулирующего фактора человека
JP2013543498A5 (enExample)
JP2016511637A5 (enExample)
JP2010526028A5 (enExample)
IL184803A (en) Purified antibodies against epha2, methods for their production, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for treating cancer
RU2013102225A (ru) АНТИТЕЛА ПРОТИВ Axl И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
JP2010523541A5 (enExample)
JP2012100677A5 (enExample)
JP2016536342A5 (enExample)
EP3178847B1 (en) Anti-tnf-alpha fully human monoclonal antibodies with low immunogenicity and application thereof
JP2008529497A5 (enExample)
JP2017519501A5 (enExample)