DE60041665D1 - Ten antikörperproduzierenden zelllinien mit verbesserten antikörpereigenschaften - Google Patents
Ten antikörperproduzierenden zelllinien mit verbesserten antikörpereigenschaftenInfo
- Publication number
- DE60041665D1 DE60041665D1 DE60041665T DE60041665T DE60041665D1 DE 60041665 D1 DE60041665 D1 DE 60041665D1 DE 60041665 T DE60041665 T DE 60041665T DE 60041665 T DE60041665 T DE 60041665T DE 60041665 D1 DE60041665 D1 DE 60041665D1
- Authority
- DE
- Germany
- Prior art keywords
- antibody
- cell lines
- properties
- improved
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108060003951 Immunoglobulin Proteins 0.000 abstract 2
- 102000018358 immunoglobulin Human genes 0.000 abstract 2
- 108700028369 Alleles Proteins 0.000 abstract 1
- 101100464532 Homo sapiens PMS2 gene Proteins 0.000 abstract 1
- 210000000628 antibody-producing cell Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000033607 mismatch repair Effects 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1024—In vivo mutagenesis using high mutation rate "mutator" host strains by inserting genetic material, e.g. encoding an error prone polymerase, disrupting a gene for mismatch repair
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2000/030588 WO2002037967A1 (en) | 2000-11-07 | 2000-11-07 | Methods for generating genetically altered antibody-producing cell lines with improved antibody characteristics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60041665D1 true DE60041665D1 (de) | 2009-04-09 |
Family
ID=21741972
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60045652T Expired - Lifetime DE60045652D1 (de) | 2000-11-07 | 2000-11-07 | Verfahren zur Erzeugung von genetisch veränderten Antikörperherstellungszelllinien mit verbesserter Antikörpereigenschaft |
| DE60041665T Expired - Lifetime DE60041665D1 (de) | 2000-11-07 | 2000-11-07 | Ten antikörperproduzierenden zelllinien mit verbesserten antikörpereigenschaften |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60045652T Expired - Lifetime DE60045652D1 (de) | 2000-11-07 | 2000-11-07 | Verfahren zur Erzeugung von genetisch veränderten Antikörperherstellungszelllinien mit verbesserter Antikörpereigenschaft |
Country Status (7)
| Country | Link |
|---|---|
| EP (2) | EP2039251B1 (de) |
| JP (1) | JP2004529613A (de) |
| AT (2) | ATE498314T1 (de) |
| AU (1) | AU2001214708A1 (de) |
| CA (1) | CA2428214C (de) |
| DE (2) | DE60045652D1 (de) |
| WO (1) | WO2002037967A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235643B2 (en) | 2000-11-07 | 2007-06-26 | Morphotek, Inc. | Antibodies and methods for generating genetically altered antibodies with high affinity |
| US6982169B2 (en) | 2001-01-15 | 2006-01-03 | Morphotek, Inc. | Chemical inhibitors of mismatch repair |
| EP1551988B1 (de) * | 2002-07-19 | 2010-11-24 | Morphotek, Inc. | VERFAHREN ZUR ERZEUGUNG VERBESSERTER ANTIKöRPER PRODUZIERENDER ZELLINIEN MIT VERBESSERTEN WACHSTUMSEIGENSCHAFTEN |
| US7754450B2 (en) | 2002-11-15 | 2010-07-13 | Morphotek, Inc. | Methods of generating high-production of antibodies from hybridomas created by in vitro immunization |
| WO2005011735A1 (en) * | 2003-07-29 | 2005-02-10 | Morphotek, Inc. | Antibodies and methods for generating genetically altered antibodies with enhanced effector function |
| US7604994B2 (en) | 2003-09-03 | 2009-10-20 | Morphotek, Inc. | Genetically altered antibody-producing cell lines with improved antibody characteristics |
| EP1716179A2 (de) * | 2004-02-12 | 2006-11-02 | Morphotek, Inc. | Monoklonaler antikörper spezifisch für den folatrezeptor alpha |
| US20060239910A1 (en) | 2005-04-22 | 2006-10-26 | Morphotek Inc. | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
| WO2008103475A1 (en) | 2007-02-20 | 2008-08-28 | Anaptysbio, Inc. | Somatic hypermutation systems |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6146894A (en) * | 1998-04-14 | 2000-11-14 | The Johns Hopkins University | Method for generating hypermutable organisms |
-
2000
- 2000-11-07 AU AU2001214708A patent/AU2001214708A1/en not_active Abandoned
- 2000-11-07 CA CA002428214A patent/CA2428214C/en not_active Expired - Lifetime
- 2000-11-07 EP EP08167325A patent/EP2039251B1/de not_active Expired - Lifetime
- 2000-11-07 JP JP2002540568A patent/JP2004529613A/ja active Pending
- 2000-11-07 AT AT08167325T patent/ATE498314T1/de not_active IP Right Cessation
- 2000-11-07 DE DE60045652T patent/DE60045652D1/de not_active Expired - Lifetime
- 2000-11-07 DE DE60041665T patent/DE60041665D1/de not_active Expired - Lifetime
- 2000-11-07 WO PCT/US2000/030588 patent/WO2002037967A1/en active Application Filing
- 2000-11-07 EP EP00977014A patent/EP1345495B1/de not_active Expired - Lifetime
- 2000-11-07 AT AT00977014T patent/ATE423467T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1345495B1 (de) | 2009-02-25 |
| EP2039251B1 (de) | 2011-02-16 |
| JP2004529613A (ja) | 2004-09-30 |
| CA2428214A1 (en) | 2002-05-16 |
| DE60045652D1 (de) | 2011-03-31 |
| EP1345495A4 (de) | 2005-08-17 |
| ATE423467T1 (de) | 2009-03-15 |
| EP1345495A1 (de) | 2003-09-24 |
| ATE498314T1 (de) | 2011-03-15 |
| AU2001214708A1 (en) | 2002-05-21 |
| EP2039251A1 (de) | 2009-03-25 |
| CA2428214C (en) | 2010-02-02 |
| WO2002037967A1 (en) | 2002-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1354034B8 (de) | Transchromosomale transgen-nagetiere zur herstellung von humänen antikörpern | |
| ATE501170T1 (de) | Verfahren zur herstellung humanisierter antikörper durch randomisierte mutagenese | |
| DK1461428T3 (da) | Fremgangsmåde til at fremstille hybridantistoffer | |
| DK1414858T3 (da) | Kamelid-enkeltkæde-VHH-antistoffer, fremgangsmåde til fremstilling heraf i et pattedyr samt anvendelser heraf | |
| WO2004024871A3 (en) | Antibodies and methods for generating genetically altered antibodies with high affinity | |
| ATE447587T1 (de) | Anti-il-20-antikörper und bindungspartner und verfahren zur anwendung bei entzündungen | |
| ATE520466T1 (de) | Apparat und verfahren zur modifizierung von magnetisch inmmobilizierte biomolekulen | |
| EP1364205A4 (de) | Produktion eines monoklonaken antikörpers durch eine transgene vogelspezies | |
| DE60041665D1 (de) | Ten antikörperproduzierenden zelllinien mit verbesserten antikörpereigenschaften | |
| DE60300016D1 (de) | Verfahren zur Erzeugung einer Rückführungsinformation über die Kanalqualität in einem System mit zwei Sendeantennen und N Empfangsantennen | |
| DE60235588D1 (de) | Monoklonales Antikörper gegen das HCV Kernantigen | |
| ATE476503T1 (de) | Verfahren zur herstellung von protein- bibliotheken und zur selektion von proteinen daraus | |
| ATE404588T1 (de) | Verfahren zur herstellung von chondroitinsulfaten aus k4-polysaccharid und so hergestellte produkte | |
| ATE505535T1 (de) | Verfahren zur herstellung stabiler b-lymphozyten | |
| ATE166882T1 (de) | Monoklonale antikörper (mak) gegen tumorassoziierte antigene, ihre herstellung und verwendung | |
| DE60329153D1 (de) | Mikroorganismus mit einem "knock-out" fadR Gen und dessen Verwendung in einem Verfahren zur Herstellung von L-Threonin | |
| ATE557040T1 (de) | Rekombinante antikörper sowie zusammensetzungen und verfahren zu deren herstellung und verwendung | |
| ATE206621T1 (de) | Il-8 antagonisten zur behandlung von asthma | |
| ATE337395T1 (de) | Hybridomzelllinie g250 und deren verwendung zur herstellung monoklonaler antikörper | |
| DE50110561D1 (de) | Non-metallocene, verfahren zur herstellung von diesen und deren verwendung zur polymerisation von olefinen | |
| HK1045715A1 (en) | Method of cell cultivation. | |
| DE50311212D1 (de) | Verfahren zur herstellung von perfluoralkylphosphinen und deren verwendung als perfluoralkylierungsreagenzien | |
| ATE132907T1 (de) | Verfahren zur verbesserten herstellung von menschlichen antikörpern sowie hierzu benutzte zellen | |
| ATE371733T1 (de) | Verfahren zur kontrollierten induktion somatischer mutationen und verwendung davon in proteomik | |
| DE60204638D1 (de) | Verfahren zur Herstellung eines zylindrischen Körpers sowie Kabel welches diesen Körper enthält |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |