ATE520466T1 - Apparat und verfahren zur modifizierung von magnetisch inmmobilizierte biomolekulen - Google Patents
Apparat und verfahren zur modifizierung von magnetisch inmmobilizierte biomolekulenInfo
- Publication number
- ATE520466T1 ATE520466T1 AT02790431T AT02790431T ATE520466T1 AT E520466 T1 ATE520466 T1 AT E520466T1 AT 02790431 T AT02790431 T AT 02790431T AT 02790431 T AT02790431 T AT 02790431T AT E520466 T1 ATE520466 T1 AT E520466T1
- Authority
- AT
- Austria
- Prior art keywords
- modifying
- immobilized biomolecules
- magnetically immobilized
- magnetically
- biomolecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/002—High gradient magnetic separation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/025—High gradient magnetic separators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/30—Combinations with other devices, not otherwise provided for
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00563—Magnetic means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
- B01L3/50255—Multi-well filtration
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/994,487 US20030099954A1 (en) | 2001-11-26 | 2001-11-26 | Apparatus and method for modification of magnetically immobilized biomolecules |
PCT/EP2002/013213 WO2003045565A1 (en) | 2001-11-26 | 2002-11-25 | Apparatus and method for modification of magnetically immobilized biomolecules |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE520466T1 true ATE520466T1 (de) | 2011-09-15 |
Family
ID=25540702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02790431T ATE520466T1 (de) | 2001-11-26 | 2002-11-25 | Apparat und verfahren zur modifizierung von magnetisch inmmobilizierte biomolekulen |
Country Status (7)
Country | Link |
---|---|
US (1) | US20030099954A1 (de) |
EP (1) | EP1450960B1 (de) |
JP (1) | JP2005510228A (de) |
AT (1) | ATE520466T1 (de) |
AU (1) | AU2002365508A1 (de) |
CA (1) | CA2468167C (de) |
WO (1) | WO2003045565A1 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
CN1617938A (zh) | 2002-01-16 | 2005-05-18 | 戴诺生物技术有限公司 | 从单个样品中分离核酸和蛋白质的方法 |
GB0229287D0 (en) * | 2002-12-16 | 2003-01-22 | Dna Res Innovations Ltd | Polyfunctional reagents |
US9487823B2 (en) | 2002-12-20 | 2016-11-08 | Qiagen Gmbh | Nucleic acid amplification |
DE10331439B3 (de) | 2003-07-10 | 2005-02-03 | Micromod Partikeltechnologie Gmbh | Magnetische Nanopartikel mit verbesserten Magneteigenschaften |
EP2402089A1 (de) | 2003-07-31 | 2012-01-04 | Handylab, Inc. | Verarbeitung partikelhaltiger Proben |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US8309303B2 (en) * | 2005-04-01 | 2012-11-13 | Qiagen Gmbh | Reverse transcription and amplification of RNA with simultaneous degradation of DNA |
EP1762627A1 (de) | 2005-09-09 | 2007-03-14 | Qiagen GmbH | Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion |
AU2005247011A1 (en) * | 2005-12-22 | 2007-07-12 | Francesco Antonio Martino | A self-contained transportable building |
EP2001990B1 (de) * | 2006-03-24 | 2016-06-29 | Handylab, Inc. | Integriertes system zur verarbeitung von mikrofluidischen proben und verwendungsverfahren |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
JP5086559B2 (ja) * | 2006-04-10 | 2012-11-28 | 株式会社島津製作所 | 反応容器及び反応容器処理装置 |
EP2091647A2 (de) | 2006-11-14 | 2009-08-26 | Handylab, Inc. | Mikrofluidisches system für parallele amplifikation und erkennung von polynukleotiden |
WO2008060604A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
WO2008109176A2 (en) | 2007-03-07 | 2008-09-12 | President And Fellows Of Harvard College | Assays and other reactions involving droplets |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
EP3741869A1 (de) | 2007-07-13 | 2020-11-25 | Handylab, Inc. | Materialien zur erfassung von polynukleotiden und verfahren zur verwendung davon |
US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
DE102007043281A1 (de) * | 2007-09-11 | 2009-05-28 | Sebastian Dr. med. Chakrit Bhakdi | Vorrichtung, Materialien und Verfahren zur Hochgradientenmagnetseparation biologischen Materials |
US9797010B2 (en) | 2007-12-21 | 2017-10-24 | President And Fellows Of Harvard College | Systems and methods for nucleic acid sequencing |
USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
US20110218123A1 (en) | 2008-09-19 | 2011-09-08 | President And Fellows Of Harvard College | Creation of libraries of droplets and related species |
US8748094B2 (en) * | 2008-12-19 | 2014-06-10 | President And Fellows Of Harvard College | Particle-assisted nucleic acid sequencing |
ES2769028T3 (es) | 2011-04-15 | 2020-06-24 | Becton Dickinson Co | Termociclador microfluídico de barrido en tiempo real |
USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
CA2849917C (en) | 2011-09-30 | 2020-03-31 | Becton, Dickinson And Company | Unitized reagent strip |
EP2773892B1 (de) | 2011-11-04 | 2020-10-07 | Handylab, Inc. | Vorrichtung zur vorbereitung von polynukleotidproben |
RU2658773C2 (ru) | 2012-02-03 | 2018-06-22 | Бектон, Дикинсон Энд Компани | Система и способ выполнения автоматизированных тестов над множеством биологических проб |
US10132798B2 (en) | 2012-05-11 | 2018-11-20 | Cornell University | Multiplexed microcolumn devices and processes for selection of nucleic acid aptamers |
US9803192B2 (en) * | 2013-10-04 | 2017-10-31 | Cornell University | Programmable and reconfigurable microcolumn affinity chromatography device, system, and methods of use thereof |
WO2015069634A1 (en) | 2013-11-08 | 2015-05-14 | President And Fellows Of Harvard College | Microparticles, methods for their preparation and use |
EP3362032A4 (de) | 2015-10-13 | 2019-05-01 | President and Fellows of Harvard College | Systeme und verfahren zur herstellung und verwendung von gel-mikrokugeln |
WO2017188346A1 (ja) * | 2016-04-27 | 2017-11-02 | 国立大学法人 東京大学 | マイクロファイバーを用いた血中循環細胞の捕捉及び回収用材料及び当該材料を用いる方法 |
CN108102875A (zh) * | 2016-11-24 | 2018-06-01 | 苏州百源基因技术有限公司 | 一种应用于核酸提取装置中的加热结构及核酸提取仪 |
CN108296013B (zh) * | 2018-03-02 | 2023-11-14 | 浙江大学 | 一种超顺磁纳米微粒的分离装置及其应用 |
CN111218441B (zh) * | 2020-02-25 | 2022-03-18 | 浙江工业大学 | 磁性固定化酵母细胞及其在制备(r)-2-羟基-4-苯基丁酸乙酯中的应用 |
CN113583865A (zh) * | 2021-10-08 | 2021-11-02 | 深圳市瑞沃德生命科技有限公司 | 分选柱的制备方法及分选柱 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
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BE792843A (fr) * | 1971-12-22 | 1973-03-30 | Kraftwerk Union Ag | Filtre electromagnetique pour oxydes de fer |
JPS54137076A (en) * | 1978-04-17 | 1979-10-24 | Unitika Ltd | Manufacturing of biaxially oriented thermoplastic polyester film |
US4230685A (en) * | 1979-02-28 | 1980-10-28 | Northwestern University | Method of magnetic separation of cells and the like, and microspheres for use therein |
US4375407A (en) * | 1981-06-22 | 1983-03-01 | The Franklin Institute | High gradient magnetic separation device |
US4452773A (en) * | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
US4554796A (en) * | 1983-01-10 | 1985-11-26 | White Consolidated Industries, Inc. | Split system air conditioner |
DE3522365A1 (de) * | 1985-06-22 | 1987-01-02 | Bayer Ag | Trenngeraet fuer magnetische partikel aus fluessiger phase |
US4664796A (en) * | 1985-09-16 | 1987-05-12 | Coulter Electronics, Inc. | Flux diverting flow chamber for high gradient magnetic separation of particles from a liquid medium |
US6020210A (en) * | 1988-12-28 | 2000-02-01 | Miltenvi Biotech Gmbh | Methods and materials for high gradient magnetic separation of biological materials |
EP0452342B1 (de) * | 1988-12-28 | 1994-11-30 | MILTENYI, Stefan | Verfahren sowie materialien zur hochgraduierten magnetischen abspaltung biologischer materialien |
US6020201A (en) * | 1994-12-22 | 2000-02-01 | Boehringer Mannheim Gmbh | Isolated nucleic acid molecules which encode mammalian or rodent 2,8 polysialyl transferases |
US5705059A (en) * | 1995-02-27 | 1998-01-06 | Miltenyi; Stefan | Magnetic separation apparatus |
US6159689A (en) * | 1995-11-10 | 2000-12-12 | Genera Technologies Limited | Methods of capture and assay procedures |
US5779892A (en) * | 1996-11-15 | 1998-07-14 | Miltenyi Biotec Gmbh | Magnetic separator with magnetic compensated release mechanism for separating biological material |
US6159376A (en) * | 1997-03-03 | 2000-12-12 | I.P. Licensing, Inc. | Laundromat wastewater treatment |
US6159378A (en) * | 1999-02-23 | 2000-12-12 | Battelle Memorial Institute | Apparatus and method for handling magnetic particles in a fluid |
DE60026729T2 (de) * | 1999-09-03 | 2006-12-14 | Miltenyi Biotec Gmbh | Verfahren zur modifikation von ausgewählten zellen in einer magnetischen zelltrennungsäule |
JP4045475B2 (ja) * | 1999-09-06 | 2008-02-13 | 東洋紡績株式会社 | 核酸・蛋白質精製装置 |
-
2001
- 2001-11-26 US US09/994,487 patent/US20030099954A1/en not_active Abandoned
-
2002
- 2002-11-25 EP EP02790431A patent/EP1450960B1/de not_active Expired - Lifetime
- 2002-11-25 CA CA2468167A patent/CA2468167C/en not_active Expired - Lifetime
- 2002-11-25 JP JP2003547059A patent/JP2005510228A/ja active Pending
- 2002-11-25 AU AU2002365508A patent/AU2002365508A1/en not_active Abandoned
- 2002-11-25 WO PCT/EP2002/013213 patent/WO2003045565A1/en active Application Filing
- 2002-11-25 AT AT02790431T patent/ATE520466T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20030099954A1 (en) | 2003-05-29 |
CA2468167A1 (en) | 2003-06-05 |
WO2003045565A1 (en) | 2003-06-05 |
JP2005510228A (ja) | 2005-04-21 |
EP1450960B1 (de) | 2011-08-17 |
AU2002365508A1 (en) | 2003-06-10 |
CA2468167C (en) | 2012-07-24 |
EP1450960A1 (de) | 2004-09-01 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |