GB0110029D0
(en)
|
2001-04-24 |
2001-06-13 |
Grosveld Frank |
Transgenic animal
|
GB0115256D0
(en)
|
2001-06-21 |
2001-08-15 |
Babraham Inst |
Mouse light chain locus
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
CA2965865C
(en)
|
2002-07-18 |
2021-10-19 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
GB0228210D0
(en)
*
|
2002-12-03 |
2003-01-08 |
Babraham Inst |
Single chain antibodies
|
GB0230203D0
(en)
*
|
2002-12-27 |
2003-02-05 |
Domantis Ltd |
Fc fusion
|
CN1756767A
(zh)
*
|
2003-02-06 |
2006-04-05 |
诺和酶股份有限公司 |
在丝状真菌中表达人重链抗体
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
WO2004106375A1
(en)
|
2003-05-30 |
2004-12-09 |
Merus Biopharmaceuticals B.V. I.O. |
Fab library for the preparation of anti vegf and anti rabies virus fabs
|
DK1737971T3
(da)
|
2004-01-20 |
2017-11-13 |
Merus Nv |
Blandinger af bindingsproteiner
|
GB2416768A
(en)
*
|
2004-07-22 |
2006-02-08 |
Univ Erasmus |
Heavy chain immunoglobulin complexes
|
CN102659940B
(zh)
*
|
2004-07-22 |
2022-07-05 |
伊拉兹马斯大学鹿特丹医学中心 |
结合分子
|
EP1800128A4
(en)
*
|
2004-09-24 |
2012-06-13 |
Univ Washington |
METHOD FOR DETERMINING AND LOWERING THE CONCENTRATION OF CAFEIN IN FLUIDS
|
FR2879605B1
(fr)
|
2004-12-16 |
2008-10-17 |
Centre Nat Rech Scient Cnrse |
Production de formats d'anticorps et applications immunologiques de ces formats
|
GB0522460D0
(en)
*
|
2005-11-03 |
2005-12-14 |
Prendergast Patrick T |
Composition and method for the treatment of avian influenza
|
CA2638117A1
(en)
*
|
2006-01-25 |
2007-08-30 |
Erasmus University Medical Center Rotterdam |
Generation of heavy-chain only antibodies in transgenic animals
|
GB0618345D0
(en)
*
|
2006-09-18 |
2006-10-25 |
Univ Erasmus |
Binding molecules
|
GB0601511D0
(en)
*
|
2006-01-25 |
2006-03-08 |
Univ Erasmus Medical Ct |
Binding Molecules 2
|
JP5105468B2
(ja)
*
|
2006-12-05 |
2012-12-26 |
独立行政法人産業技術総合研究所 |
細胞内で機能する抗体の創製および細胞表現型を制御するタンパク質の同定
|
US9156914B2
(en)
|
2006-12-19 |
2015-10-13 |
Ablynx N.V. |
Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders
|
WO2012130874A1
(en)
|
2011-03-28 |
2012-10-04 |
Ablynx Nv |
Bispecific anti-cxcr7 immunoglobulin single variable domains
|
EP2557090A3
(en)
|
2006-12-19 |
2013-05-29 |
Ablynx N.V. |
Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
|
WO2009138519A1
(en)
|
2008-05-16 |
2009-11-19 |
Ablynx Nv |
AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME
|
GB0706628D0
(en)
*
|
2007-04-04 |
2007-05-16 |
Univ Erasmus |
Germ-line manipulation 1
|
JP5823690B2
(ja)
|
2007-06-01 |
2015-11-25 |
オーエムティー,インコーポレイティド |
内在性免疫グロブリン遺伝子を阻害し、そして、トランスジェニック・ヒト・イディオタイプ抗体を製造するための組成物及び方法
|
AU2008328781A1
(en)
|
2007-11-27 |
2009-06-04 |
Ablynx N.V. |
Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
|
GB0809069D0
(en)
|
2008-05-19 |
2008-06-25 |
Univ Leuven Kath |
Gene signatures
|
ES2447844T3
(es)
|
2008-04-03 |
2014-03-13 |
Vib Vzw |
Anticuerpos de dominio individual capaces de modular la actividad BACE1
|
US9908943B2
(en)
|
2008-04-03 |
2018-03-06 |
Vib Vzw |
Single domain antibodies capable of modulating BACE activity
|
EP2260058A2
(en)
|
2008-04-07 |
2010-12-15 |
Ablynx N.V. |
Single variable domains against the notch pathways
|
US9193780B2
(en)
|
2008-06-05 |
2015-11-24 |
Ablynx N.V. |
Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases
|
CN104004094B
(zh)
*
|
2008-06-25 |
2017-09-22 |
艾斯巴技术-诺华有限责任公司 |
使用通用抗体构架进行的兔抗体的人源化
|
US20100136584A1
(en)
*
|
2008-09-22 |
2010-06-03 |
Icb International, Inc. |
Methods for using antibodies and analogs thereof
|
WO2010033913A1
(en)
*
|
2008-09-22 |
2010-03-25 |
Icb International, Inc. |
Antibodies, analogs and uses thereof
|
DK2370465T3
(da)
|
2008-12-19 |
2019-05-06 |
Ablynx Nv |
Genetisk immunisering til fremstilling af immunoglobuliner mod celleassocierede antigener, såsom p2x7, cxcr7 eller cxcr4
|
EP2387584A1
(en)
|
2009-01-14 |
2011-11-23 |
IQ Therapeutics BV |
Combination antibodies for the treatment and prevention of disease caused by bacillus anthracis and related bacteria and their toxins
|
GB0905023D0
(en)
|
2009-03-24 |
2009-05-06 |
Univ Erasmus Medical Ct |
Binding molecules
|
US9340605B2
(en)
|
2009-10-22 |
2016-05-17 |
Universiteit Twente |
VHH for application in tissue repair, organ regeneration, organ replacement and tissue engineering
|
DK2509409T3
(da)
|
2009-12-10 |
2016-11-14 |
Regeneron Pharma |
Mus, der producerer tungkædeantistoffer
|
WO2011073180A1
(en)
|
2009-12-14 |
2011-06-23 |
Ablynx N.V. |
Single variable domain antibodies against ox40l, constructs and therapeutic use
|
WO2011083141A2
(en)
|
2010-01-08 |
2011-07-14 |
Ablynx Nv |
Method for generation of immunoglobulin sequences by using lipoprotein particles
|
US9796788B2
(en)
|
2010-02-08 |
2017-10-24 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing a limited immunoglobulin light chain repertoire
|
HUE026229T2
(en)
|
2010-02-08 |
2016-06-28 |
Regeneron Pharma |
Common light chain mouse
|
US20130045492A1
(en)
|
2010-02-08 |
2013-02-21 |
Regeneron Pharmaceuticals, Inc. |
Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
|
US9120855B2
(en)
|
2010-02-10 |
2015-09-01 |
Novartis Ag |
Biologic compounds directed against death receptor 5
|
US8937164B2
(en)
|
2010-03-26 |
2015-01-20 |
Ablynx N.V. |
Biological materials related to CXCR7
|
US9101674B2
(en)
|
2010-03-29 |
2015-08-11 |
Vib Vzw |
Targeting and in vivo imaging of tumor-associated macrophages
|
US9556273B2
(en)
|
2010-03-29 |
2017-01-31 |
Vib Vzw |
Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
|
GB201014715D0
(en)
|
2010-09-06 |
2010-10-20 |
Vib Vzw |
Nanobodies stabilizing functional conformational states of GPCRS
|
NZ707327A
(en)
|
2010-08-02 |
2017-01-27 |
Regeneron Pharma |
Mice that make binding proteins comprising vl domains
|
WO2012025619A1
(en)
|
2010-08-26 |
2012-03-01 |
Vib Vzw |
Chitinous polysaccharide antigen binding proteins
|
SG189981A1
(en)
|
2010-11-08 |
2013-06-28 |
Novartis Ag |
Cxcr2 binding polypeptides
|
UA117218C2
(uk)
|
2011-05-05 |
2018-07-10 |
Мерк Патент Гмбх |
Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
|
DK2723764T3
(da)
|
2011-06-21 |
2018-03-12 |
Vib Vzw |
Bindingsdomæner rettet mod GPCR:G-proteinkomplekser og anvendelser afledt deraf
|
CN103917650B
(zh)
|
2011-08-05 |
2017-10-24 |
瑞泽恩制药公司 |
人源化的通用轻链小鼠
|
US20150158934A1
(en)
*
|
2011-09-09 |
2015-06-11 |
Ucl Business Plc |
Broadly neutralizing vhh against hiv-1
|
EP2758534B1
(en)
|
2011-09-19 |
2020-04-29 |
Kymab Limited |
Animals, repertoires & methods for the production of human antibodies
|
SG10202010120XA
(en)
|
2011-10-17 |
2020-11-27 |
Regeneron Pharma |
Restricted immunoglobulin heavy chain mice
|
CN102372779A
(zh)
*
|
2011-10-25 |
2012-03-14 |
李江伟 |
具有蒜氨酸酶活性的骆驼单域抗体及制备方法和应用
|
US10112987B2
(en)
|
2012-01-09 |
2018-10-30 |
Icb International, Inc. |
Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide
|
US10112988B2
(en)
|
2012-01-09 |
2018-10-30 |
Icb International, Inc. |
Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide
|
EP2617732A1
(en)
|
2012-01-19 |
2013-07-24 |
Vib Vzw |
Tools and methods for expression of membrane proteins
|
CN102660551B
(zh)
*
|
2012-02-09 |
2014-04-16 |
陈志南 |
来源于抗CypA骆驼科动物的重链VHH抗体基因、编码多肽及其应用
|
SG10201607727PA
(en)
*
|
2012-03-16 |
2016-11-29 |
Regeneron Pharma |
Mice that produce antigen-binding proteins with ph-dependent binding characteristics
|
GB2502127A
(en)
|
2012-05-17 |
2013-11-20 |
Kymab Ltd |
Multivalent antibodies and in vivo methods for their production
|
SG11201405059XA
(en)
|
2012-03-28 |
2014-09-26 |
Kymab Ltd |
Transgenic non-human vertebrate for the expression of class - switched, fully human, antibodies
|
SG10201607369QA
(en)
|
2012-04-20 |
2016-10-28 |
Merus Nv |
Methods and means for the production of ig-like molecules
|
US9328174B2
(en)
|
2012-05-09 |
2016-05-03 |
Novartis Ag |
Chemokine receptor binding polypeptides
|
EP2855526B1
(en)
|
2012-05-24 |
2018-11-07 |
VIB vzw |
Anti-macrophage mannose receptor immunoglobulin single variable domains for targeting and in vivo imaging of tumor-associated macrophages
|
KR102381716B1
(ko)
|
2012-06-12 |
2022-04-01 |
리제너론 파마슈티칼스 인코포레이티드 |
제한된 면역글로불린 중쇄 유전자좌를 가지는 인간화된 비-인간 동물
|
LT3653049T
(lt)
|
2012-12-14 |
2023-11-10 |
Omniab, Inc. |
Polinukleotidai, koduojantys graužikų antikūnus, turinčius žmogaus idiotipus, ir gyvūnai, apimantys juos
|
CN112858672A
(zh)
|
2013-01-30 |
2021-05-28 |
弗拉芒区生物技术研究所 |
用于筛选和药物发现目的的新型嵌合多肽
|
PT2953973T
(pt)
|
2013-02-05 |
2019-10-25 |
Univ Brussel Vrije |
Agentes de ligação do receptor muscarínico de acetilololina e usos
|
ES2678221T3
(es)
|
2013-02-20 |
2018-08-09 |
Regeneron Pharmaceuticals, Inc. |
Animales no humanos con secuencias de cadena pesada de inmunoglobulina modificadas
|
AU2014229952B2
(en)
|
2013-03-15 |
2018-10-04 |
Vib Vzw |
Anti-macrophage mannose receptor single variable domains for use in cardiovascular diseases
|
WO2014141192A1
(en)
|
2013-03-15 |
2014-09-18 |
Erasmus University Medical Center |
Generation of heavy chain-only antibodies
|
CN105358698B
(zh)
*
|
2013-04-29 |
2024-02-20 |
生物催化公司 |
包含结合至鞘脂的抗体的农用化学组合物
|
EP3013362B1
(en)
|
2013-06-28 |
2021-08-04 |
Baylor Research Institute |
Dendritic cell asgpr targeting immunotherapeutics for multiple sclerosis
|
CN103454413B
(zh)
*
|
2013-09-04 |
2015-03-11 |
吉日木图 |
双峰驼特异性抗体制备及免疫检测方法
|
WO2015121092A1
(en)
|
2014-01-30 |
2015-08-20 |
Vib Vzw |
Opioid receptor binding agents and uses thereof
|
CA2941514A1
(en)
|
2014-03-21 |
2015-09-24 |
Regeneron Pharmaceuticals, Inc. |
Vl antigen binding proteins exhibiting distinct binding characteristics
|
CN106255410B
(zh)
|
2014-03-21 |
2020-01-10 |
瑞泽恩制药公司 |
产生单结构域结合蛋白的非人动物
|
SG11201604886WA
(en)
*
|
2014-04-08 |
2016-07-28 |
Regeneron Pharma |
Non-human animals having humanized fc-gamma receptors
|
JP2018508224A
(ja)
|
2015-03-19 |
2018-03-29 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
抗原を結合する軽鎖可変領域を選択する非ヒト動物
|
KR20190080992A
(ko)
|
2015-05-21 |
2019-07-08 |
하푼 테라퓨틱스, 인크. |
삼중특이성 결합 단백질 및 사용 방법
|
EP3328886B1
(en)
|
2015-07-29 |
2020-09-16 |
Allergan, Inc. |
Heavy chain only antibodies to ang-2
|
CN105384825B
(zh)
|
2015-08-11 |
2018-06-01 |
南京传奇生物科技有限公司 |
一种基于单域抗体的双特异性嵌合抗原受体及其应用
|
JP2018523673A
(ja)
|
2015-08-14 |
2018-08-23 |
アラーガン、インコーポレイテッドAllergan,Incorporated |
Pdgfに対する重鎖のみ抗体
|
WO2017058944A1
(en)
|
2015-09-29 |
2017-04-06 |
Amgen Inc. |
Asgr inhibitors
|
CN105504053B
(zh)
*
|
2015-12-25 |
2019-04-16 |
中国农业科学院兰州兽医研究所 |
一种猪流行性腹泻病毒m蛋白特异性重链抗体
|
US10988538B2
(en)
|
2016-02-05 |
2021-04-27 |
Orionis Biosciences BV |
Bispecific signaling agents and uses thereof
|
EP3426278B1
(en)
|
2016-03-07 |
2024-01-03 |
Vib Vzw |
Cd20 binding single domain antibodies
|
CN105777894A
(zh)
*
|
2016-03-12 |
2016-07-20 |
长春力太生物技术有限公司 |
通过转基因啮齿类动物制备人源化驼类单域抗体的方法
|
CA3017813C
(en)
|
2016-03-17 |
2021-12-07 |
Oslo Universitetssykehus Hf |
Fusion proteins targeting tumour associated macrophages for treating cancer
|
US11753463B2
(en)
|
2016-05-13 |
2023-09-12 |
Orionis Biosciences BV |
Therapeutic targeting of non-cellular structures
|
EP3493844A4
(en)
|
2016-05-20 |
2021-03-24 |
Harpoon Therapeutics Inc. |
SINGLE DOMAIN SERIAL ALBUMIN BINDING PROTEIN
|
US11623958B2
(en)
|
2016-05-20 |
2023-04-11 |
Harpoon Therapeutics, Inc. |
Single chain variable fragment CD3 binding proteins
|
US10544221B2
(en)
|
2016-05-20 |
2020-01-28 |
Harpoon Therapeutics, Inc. |
Single chain variable fragment CD3 binding proteins
|
WO2018014260A1
(en)
|
2016-07-20 |
2018-01-25 |
Nanjing Legend Biotech Co., Ltd. |
Multispecific antigen binding proteins and methods of use thereof
|
KR20230039773A
(ko)
*
|
2016-08-24 |
2023-03-21 |
테네오바이오, 인코포레이티드 |
변형된 중쇄-단독 항체를 생산하는 형질전환 비-인간 동물
|
WO2018068201A1
(en)
|
2016-10-11 |
2018-04-19 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies and variants thereof against ctla-4
|
EP3544629A4
(en)
|
2016-11-23 |
2020-06-17 |
Harpoon Therapeutics, Inc. |
TRISPECIFIC PROTEINS CIBLANG PSMA AND METHODS OF USE
|
CN110198955A
(zh)
|
2016-11-23 |
2019-09-03 |
哈普恩治疗公司 |
前列腺特异性膜抗原结合蛋白质
|
WO2018103093A1
(zh)
*
|
2016-12-09 |
2018-06-14 |
深圳华大基因研究院 |
骆驼科抗体可变区免疫组库构建的引物组合及应用
|
EP3332637A1
(en)
*
|
2016-12-09 |
2018-06-13 |
Universitätsklinikum Hamburg-Eppendorf |
Vhh-containing heavy chain antibody and production thereof
|
SG10202109874VA
(en)
|
2017-01-19 |
2021-10-28 |
Open Monoclonal Tech Inc |
Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci
|
JP7476467B2
(ja)
|
2017-02-06 |
2024-05-01 |
オリオンズ バイオサイエンス ビーブイ |
標的化キメラタンパク質及びその使用
|
US11535668B2
(en)
|
2017-02-28 |
2022-12-27 |
Harpoon Therapeutics, Inc. |
Inducible monovalent antigen binding protein
|
SG10202107880XA
(en)
|
2017-05-12 |
2021-09-29 |
Harpoon Therapeutics Inc |
Mesothelin binding proteins
|
US10730954B2
(en)
|
2017-05-12 |
2020-08-04 |
Harpoon Therapeutics, Inc. |
MSLN targeting trispecific proteins and methods of use
|
US11225514B2
(en)
|
2017-05-30 |
2022-01-18 |
The Regents Of The University Of California |
Nanobodies against cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif)
|
US10927180B2
(en)
|
2017-10-13 |
2021-02-23 |
Harpoon Therapeutics, Inc. |
B cell maturation antigen binding proteins
|
CR20200196A
(es)
|
2017-10-13 |
2020-06-05 |
Harpoon Therapeutics Inc |
Proteínas trispecìficas y mètodos de uso
|
US10017560B1
(en)
|
2017-11-16 |
2018-07-10 |
King Saud University |
Nanobody against begomoviruses
|
WO2019129221A1
(en)
|
2017-12-28 |
2019-07-04 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies and variants thereof against tigit
|
CA3084518A1
(en)
|
2018-01-15 |
2019-07-18 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies and variants thereof against pd-1
|
KR20200128533A
(ko)
|
2018-02-05 |
2020-11-13 |
오리오니스 바이오사이언시즈 인코포레이티드 |
섬유아세포 결합제 및 이의 용도
|
KR20200138720A
(ko)
|
2018-03-30 |
2020-12-10 |
난징 레전드 바이오테크 씨오., 엘티디. |
Lag-3에 대한 단일-도메인 항체 및 이의 용도
|
GB2576914A
(en)
|
2018-09-06 |
2020-03-11 |
Kymab Ltd |
Antigen-binding molecules comprising unpaired variable domains produced in mammals
|
KR20210086623A
(ko)
|
2018-09-25 |
2021-07-08 |
하푼 테라퓨틱스, 인크. |
Ddl3 결합 단백질 및 사용 방법
|
US20220267462A1
(en)
|
2019-05-14 |
2022-08-25 |
Harpoon Therapeutics, Inc. |
Epcam binding proteins and methods of use
|
MA56110A
(fr)
|
2019-06-07 |
2022-04-13 |
Amgen Inc |
Constructions de liaison bispécifiques à lieurs clivables de manière sélective
|
CN112574308A
(zh)
|
2019-09-30 |
2021-03-30 |
和铂医药(苏州)有限公司 |
靶向bcma的抗体、双特异性抗体及其用途
|
IL295448A
(en)
|
2020-02-21 |
2022-10-01 |
Harpoon Therapeutics Inc |
flt3 binding proteins and methods of use
|
CA3184351A1
(en)
|
2020-06-04 |
2021-12-09 |
Amgen Inc. |
Bispecific binding constructs
|
WO2022002063A1
(zh)
|
2020-06-30 |
2022-01-06 |
和铂医药(上海)有限责任公司 |
一种4-1bb结合蛋白及其应用
|
US20230270086A1
(en)
*
|
2020-07-13 |
2023-08-31 |
Kisoji Biotechnology Inc. |
Transgenic animals expressing heavy chain antibodies
|
IL303205A
(en)
|
2020-12-03 |
2023-07-01 |
Amgen Inc |
IMMUNOGLOBULINE constructs with multiple binding domains
|
WO2022156907A1
(en)
|
2021-01-25 |
2022-07-28 |
Vrije Universiteit Brussel |
Method and kit for labeling a biomolecule with one or more detectable labels, including a radiolabel
|
WO2022156908A1
(en)
|
2021-01-25 |
2022-07-28 |
Vrije Universiteit Brussel |
Method for preparing a lyophilized composition
|
WO2022157373A1
(en)
|
2021-01-25 |
2022-07-28 |
Vrije Universiteit Brussel |
Compositions and kits for in vivo imaging of cardiac sarcoidosis
|
IL305301A
(en)
|
2021-02-19 |
2023-10-01 |
Us Health |
Single domain antibodies neutralizing SARS CoV-2
|
WO2022221120A1
(en)
|
2021-04-16 |
2022-10-20 |
Bio-Techne Corporation |
Camelid anti-severe acute respiratory syndrome coronavirus antibodies
|
WO2022247826A1
(zh)
|
2021-05-28 |
2022-12-01 |
和铂医药(上海)有限责任公司 |
靶向pd-l1和cd73的特异性结合蛋白
|
KR20240046557A
(ko)
|
2021-08-18 |
2024-04-09 |
하버 바이오메드 (상하이) 컴퍼니 리미티드 |
항-b7-h4 항체 및 이의 제조 방법과 용도
|
WO2023057508A1
(en)
|
2021-10-05 |
2023-04-13 |
Vrije Universiteit Brussel |
Fluorescently labeled immunoglobulin single variable domai ns
|
WO2023170553A1
(en)
|
2022-03-07 |
2023-09-14 |
Takeda Pharmaceutical Company Limited |
Affinity chromatographic production of clinical human igg products
|
EP4349374A1
(en)
|
2022-10-05 |
2024-04-10 |
Vrije Universiteit Brussel |
Anti-urokinase plasminogen activator receptor immunoglobulin single variable domains
|
WO2024083843A1
(en)
|
2022-10-18 |
2024-04-25 |
Confo Therapeutics N.V. |
Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders
|