CN104250302A - 抗pd-1抗体及其应用 - Google Patents
抗pd-1抗体及其应用 Download PDFInfo
- Publication number
- CN104250302A CN104250302A CN201310258289.2A CN201310258289A CN104250302A CN 104250302 A CN104250302 A CN 104250302A CN 201310258289 A CN201310258289 A CN 201310258289A CN 104250302 A CN104250302 A CN 104250302A
- Authority
- CN
- China
- Prior art keywords
- seq
- antibody
- variant
- cancer
- carcinoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/04—Amoebicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
Abstract
Description
HCDR1 | HCDR2 | HCDR3 | |
A | SEQ ID NO:1 | SEQ ID NO:2 | SEQ ID NO:3 |
B | SEQ ID NO:7 | SEQ ID NO:8 | SEQ ID NO:9 |
C | SEQ ID NO:13 | SEQ ID NO:14 | SEQIDNO:15 |
LCDR1 | LCDR2 | LCDR3 | |
A | SEQ ID NO:4 | SEQ ID NO:5 | SEQ ID NO:6 |
B | SEQ ID NO:10 | SEQ ID NO:11 | SEQ ID NO:12 |
C | SEQ ID NO:16 | SEQ ID NO:17 | SEQ ID NO:18 |
HCDR1 | HCDR2 | HCDR3 | LCDR1 | LCDR2 | LCDR3 | |
A | SEQ ID NO:1 | SEQ ID NO:2 | SEQ ID NO:3 | SEQ ID NO:4 | SEQIDNO:5 | SEQ ID NO:6 |
B | SEQ ID NO:7 | SEQ ID NO:8 | SEQIDNO:9 | SEQ ID NO:10 | SEQ ID NO:11 | SEQ ID NO:12 |
C | SEQ ID NO:13 | SEQ ID NO:14 | SEQ ID NO:15 | SEQ ID NO:16 | SEQ ID NO:17 | SEQ IDNO:18 |
样品 | H1L1 | H10L10 | H1L10 | H10L1 |
EC50(pM) | 338.1 | 426.3 | 270.1 | 528.1 |
Claims (15)
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310258289.2A CN104250302B (zh) | 2013-06-26 | 2013-06-26 | 抗pd‑1抗体及其应用 |
PT148187081T PT3026062T (pt) | 2013-06-26 | 2014-02-26 | Anticorpo anti-pd-1 e utilização do mesmo |
US14/392,360 US10066013B2 (en) | 2013-06-26 | 2014-02-26 | Anti-PD-1 antibody and use thereof |
EP20189272.6A EP3845562A1 (en) | 2013-06-26 | 2014-02-26 | Anti-pd-1 antibody and use thereof |
ES14818708T ES2822927T3 (es) | 2013-06-26 | 2014-02-26 | Anticuerpo anti-PD-1 y su uso |
HUE14818708A HUE052487T2 (hu) | 2013-06-26 | 2014-02-26 | Anti-PD-1 antitest és annak alkalmazása |
JP2016522196A JP6681327B2 (ja) | 2013-06-26 | 2014-02-26 | 抗pd−1抗体およびその応用 |
EP14818708.1A EP3026062B1 (en) | 2013-06-26 | 2014-02-26 | Anti-pd-1 antibody and use thereof |
MYPI2015704733A MY176822A (en) | 2013-06-26 | 2014-02-26 | Anti-pd-1 antibody and use thereof |
DK14818708.1T DK3026062T3 (da) | 2013-06-26 | 2014-02-26 | Anti-pd-1-antistof og anvendelse deraf |
SI201431678T SI3026062T1 (sl) | 2013-06-26 | 2014-02-26 | ANTI-PD-1 protitelo in njegova uporaba |
RU2016102176A RU2663795C2 (ru) | 2013-06-26 | 2014-02-26 | Антитело к pd-1 и его применение |
BR112015031883-5A BR112015031883A2 (pt) | 2013-06-26 | 2014-02-26 | anti-pd-1 anticorpo e o uso dele |
PCT/CN2014/072574 WO2014206107A1 (zh) | 2013-06-26 | 2014-02-26 | 抗pd-1抗体及其应用 |
PL14818708T PL3026062T3 (pl) | 2013-06-26 | 2014-02-26 | Przeciwciała anty-pd-1 i ich zastosowanie |
PH12015502819A PH12015502819A1 (en) | 2013-06-26 | 2015-12-18 | Anti-pd-1 antibody and use thereof |
US16/045,363 US10815302B2 (en) | 2013-06-26 | 2018-07-25 | Anti-PD-1 antibody and use thereof |
US17/022,719 US20210009688A1 (en) | 2013-06-26 | 2020-09-16 | Anti-pd-1 antibody and use thereof |
HRP20201600TT HRP20201600T1 (hr) | 2013-06-26 | 2020-10-07 | Anti-pd-1 antitijelo i njegova uporaba |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310258289.2A CN104250302B (zh) | 2013-06-26 | 2013-06-26 | 抗pd‑1抗体及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104250302A true CN104250302A (zh) | 2014-12-31 |
CN104250302B CN104250302B (zh) | 2017-11-14 |
Family
ID=52140971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310258289.2A Active CN104250302B (zh) | 2013-06-26 | 2013-06-26 | 抗pd‑1抗体及其应用 |
Country Status (16)
Country | Link |
---|---|
US (3) | US10066013B2 (zh) |
EP (2) | EP3845562A1 (zh) |
JP (1) | JP6681327B2 (zh) |
CN (1) | CN104250302B (zh) |
BR (1) | BR112015031883A2 (zh) |
DK (1) | DK3026062T3 (zh) |
ES (1) | ES2822927T3 (zh) |
HR (1) | HRP20201600T1 (zh) |
HU (1) | HUE052487T2 (zh) |
MY (1) | MY176822A (zh) |
PH (1) | PH12015502819A1 (zh) |
PL (1) | PL3026062T3 (zh) |
PT (1) | PT3026062T (zh) |
RU (1) | RU2663795C2 (zh) |
SI (1) | SI3026062T1 (zh) |
WO (1) | WO2014206107A1 (zh) |
Cited By (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105566496A (zh) * | 2015-11-26 | 2016-05-11 | 大庆东竺明生物技术有限公司 | 阻断人程序性死亡因子1(pd-1)功能的单克隆抗体及其编码基因和应用 |
CN105950715A (zh) * | 2016-04-27 | 2016-09-21 | 深圳市第三人民医院 | 检测δ42pd1的方法、引物及试剂盒 |
CN106046162A (zh) * | 2016-06-21 | 2016-10-26 | 大庆东竺明生物技术有限公司 | 抗人程序性死亡因子1(pd‑1)单克隆抗体的制备及应用 |
CN106085955A (zh) * | 2016-06-08 | 2016-11-09 | 中南大学 | 一种同时分离外周血t、b淋巴细胞的方法 |
CN106390115A (zh) * | 2015-07-29 | 2017-02-15 | 上海君实生物医药科技股份有限公司 | 一种人源化单克隆抗体的稳定制剂 |
WO2017024465A1 (en) * | 2015-08-10 | 2017-02-16 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
CN106432494A (zh) * | 2015-08-11 | 2017-02-22 | 哈尔滨誉衡药业股份有限公司 | 新型抗‑pd‑1抗体 |
WO2017058115A1 (en) | 2015-09-29 | 2017-04-06 | Asia Biotech Pte. Ltd. | Pd-1 antibodies and uses thereof |
CN106699888A (zh) * | 2015-07-28 | 2017-05-24 | 钜川生物医药 | 一种pd-1抗体及其制备方法和应用 |
WO2017132827A1 (en) * | 2016-02-02 | 2017-08-10 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
WO2017148424A1 (zh) * | 2016-03-04 | 2017-09-08 | 四川科伦博泰生物医药股份有限公司 | 一种pdl-1抗体、其药物组合物及其用途 |
WO2017201766A1 (zh) * | 2016-05-24 | 2017-11-30 | 瑞阳(苏州)生物科技有限公司 | 抗人pd-1人源化单克隆抗体及其应用 |
CN107446048A (zh) * | 2017-09-13 | 2017-12-08 | 北京韩美药品有限公司 | 一种能够特异性地结合pd‑1的抗体及其功能片段 |
WO2018036472A1 (zh) * | 2016-08-23 | 2018-03-01 | 中山康方生物医药有限公司 | 一种抗pd1单克隆抗体、其药物组合物及其用途 |
WO2018050027A1 (zh) * | 2016-09-14 | 2018-03-22 | 北京韩美药品有限公司 | 一种能够特异性地结合pd-1的抗体及其功能片段 |
CN108025069A (zh) * | 2015-09-03 | 2018-05-11 | 小野药品工业株式会社 | 使用变应素-1拮抗剂的癌症免疫增强剂 |
CN108112254A (zh) * | 2015-03-13 | 2018-06-01 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
WO2018133837A1 (en) * | 2017-01-20 | 2018-07-26 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Anti-pd-1 antibodies and uses thereof |
CN108601829A (zh) * | 2015-11-18 | 2018-09-28 | 礼进生物医药科技(上海)有限公司 | 抗pd-1抗体及其治疗用途 |
CN108840932A (zh) * | 2018-04-28 | 2018-11-20 | 中国科学院微生物研究所 | 一种pd-1特异性抗体及其抗肿瘤应用 |
CN109160949A (zh) * | 2018-07-23 | 2019-01-08 | 中国医学科学院血液病医院(血液学研究所) | 一种鼠抗人pd-1单克隆抗体及应用 |
CN109467603A (zh) * | 2017-11-14 | 2019-03-15 | 拜西欧斯(北京)生物技术有限公司 | 抗pd-1抗体及其制备方法和应用 |
WO2019062755A1 (en) * | 2017-09-29 | 2019-04-04 | Wuxi Biologics (Shanghai) Co., Ltd. | BISPECIFIC ANTIBODIES DIRECTED AGAINST EGFR AND PD-1 |
CN110882385A (zh) * | 2018-09-07 | 2020-03-17 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗肿瘤中的用途 |
WO2020143749A1 (zh) | 2019-01-10 | 2020-07-16 | 迈威(上海)生物科技有限公司 | 重组抗人pd-1抗体及其应用 |
WO2020156509A1 (zh) * | 2019-02-03 | 2020-08-06 | 江苏恒瑞医药股份有限公司 | 抗pd-1抗体、其抗原结合片段及医药用途 |
WO2020211804A1 (zh) * | 2019-04-17 | 2020-10-22 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在制备治疗实体瘤的药物中的用途 |
CN112159476A (zh) * | 2020-10-10 | 2021-01-01 | 中国药科大学 | 一种用于多发性骨髓瘤的双特异性抗体及其应用 |
WO2021063201A1 (zh) * | 2019-09-30 | 2021-04-08 | 四川科伦博泰生物医药股份有限公司 | 抗pd-1抗体及其用途 |
US11008391B2 (en) | 2015-08-11 | 2021-05-18 | WuXi Biologics Ireland Limited | Anti-PD-1 antibodies |
CN113087796A (zh) * | 2021-04-02 | 2021-07-09 | 河南省肿瘤医院 | 一种抗pd-l1抗体及其应用 |
CN113166239A (zh) * | 2018-12-12 | 2021-07-23 | 上海君实生物医药科技股份有限公司 | 抗il-17a抗体及其应用 |
WO2021155840A1 (zh) * | 2020-02-07 | 2021-08-12 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗恶性肿瘤中的用途 |
WO2021160152A1 (zh) * | 2020-02-13 | 2021-08-19 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗神经内分泌瘤中的用途 |
WO2021160151A1 (zh) * | 2020-02-13 | 2021-08-19 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗肿瘤中的用途 |
WO2021180027A1 (zh) * | 2020-03-09 | 2021-09-16 | 和记黄埔医药(上海)有限公司 | 抗pd-1抗体和多受体酪氨酸激酶抑制剂的药物组合及其使用方法 |
US11155626B2 (en) | 2016-05-20 | 2021-10-26 | Reyoung (Suzhou) Biology Science & Technology Co., Ltd | Anti-human PD-L1 humanized monoclonal antibody and application thereof |
WO2022012639A1 (zh) * | 2020-07-16 | 2022-01-20 | 和铂医药(上海)有限责任公司 | Pd-1抗原结合蛋白及其应用 |
WO2022042720A1 (en) * | 2020-08-31 | 2022-03-03 | Biosion Inc. | Pd-1 binding antibodies and uses thereof |
WO2022063314A1 (zh) * | 2020-09-28 | 2022-03-31 | 上海君实生物医药科技股份有限公司 | 靶向PD-1或PD-L1和TGF-β的双功能蛋白及其医药用途 |
US11345754B2 (en) | 2017-04-20 | 2022-05-31 | Acroimmune Biopharma Co., Ltd. | Monoclonal antibody antagonizing and inhibiting the binding of human PD-1 antigen to its ligand, preparation method therefor and application thereof |
WO2022223006A1 (zh) * | 2021-04-22 | 2022-10-27 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体联合一线化疗治疗晚期非小细胞肺癌的用途 |
WO2023006055A1 (en) * | 2021-07-29 | 2023-02-02 | Shanghai Junshi Biosciences Co., Ltd. | Anti-pd-1 antibody pharmaceutical composition and use thereof |
RU2807484C2 (ru) * | 2019-02-03 | 2023-11-15 | Цзянсу Хэнжуй Медсин Ко., Лтд. | Антитело к pd-1, его антигенсвязывающий фрагмент и его фармацевтическое применение |
Families Citing this family (179)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104250302B (zh) | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
PT3081576T (pt) | 2013-12-12 | 2019-10-15 | Jiangsu Hengrui Medicine Co | Anticorpo pd-1, fragmento de ligação ao antigénio do mesmo e aplicação médica do mesmo |
US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
US10144778B2 (en) | 2014-03-12 | 2018-12-04 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
US9982052B2 (en) | 2014-08-05 | 2018-05-29 | MabQuest, SA | Immunological reagents |
DK3177644T3 (da) | 2014-08-05 | 2021-01-11 | MabQuest SA | Immunologiske reagenser, som binder til PD-1 |
CA2971734A1 (en) * | 2014-12-22 | 2016-06-30 | Enumeral Biomedical Holdings, Inc. | Anti-pd-1 antibodies |
US11639385B2 (en) | 2014-12-22 | 2023-05-02 | Pd-1 Acquisition Group, Llc | Anti-PD-1 antibodies |
PT3303394T (pt) | 2015-05-29 | 2020-07-01 | Ludwig Inst For Cancer Res Ltd | Anticorpos anti-ctla-4 e métodos de uso dos mesmos |
CN105061597B (zh) * | 2015-06-09 | 2016-04-27 | 北京东方百泰生物科技有限公司 | 一种抗pd-1的单克隆抗体及其获得方法 |
AU2016294440B2 (en) | 2015-07-13 | 2022-10-13 | Cytomx Therapeutics, Inc | Anti-PD-1 antibodies, activatable anti-PD-1 antibodies, and methods of use thereof |
MA42459A (fr) | 2015-07-16 | 2018-05-23 | Bioxcel Therapeutics Inc | Nouvelle approche pour le traitement du cancer par immunomodulation |
KR20220131277A (ko) | 2015-09-01 | 2022-09-27 | 아게누스 인코포레이티드 | 항-pd-1 항체 및 이를 이용하는 방법 |
AU2016332725A1 (en) | 2015-09-29 | 2018-03-22 | Celgene Corporation | PD-1 binding proteins and methods of use thereof |
TWI751981B (zh) | 2015-10-02 | 2022-01-11 | 丹麥商賽門弗鎮公司 | 抗pd-1抗體及組成物 |
US11207393B2 (en) * | 2015-10-16 | 2021-12-28 | President And Fellows Of Harvard College | Regulatory T cell PD-1 modulation for regulating T cell effector immune responses |
BR112018008891A8 (pt) | 2015-11-03 | 2019-02-26 | Janssen Biotech Inc | anticorpos que se ligam especificamente a pd-1 e tim-3 e seus usos |
WO2017125815A2 (en) * | 2016-01-22 | 2017-07-27 | MabQuest SA | Immunological reagents |
US11214617B2 (en) | 2016-01-22 | 2022-01-04 | MabQuest SA | Immunological reagents |
MA45123A (fr) | 2016-05-27 | 2019-04-10 | Agenus Inc | Anticorps anti-tim-3 et leurs méthodes d'utilisation |
RU2756236C2 (ru) | 2016-06-20 | 2021-09-28 | Кимаб Лимитед | PD-L1 специфические антитела |
CN106967172B (zh) | 2016-08-23 | 2019-01-08 | 康方药业有限公司 | 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 |
WO2018035710A1 (en) | 2016-08-23 | 2018-03-01 | Akeso Biopharma, Inc. | Anti-ctla4 antibodies |
US11072651B2 (en) | 2016-09-14 | 2021-07-27 | Beijing Hanmi Pharm. Co., Ltd. | Antibody specifically binding to IL-17A, encoding nucleic acid, and method of using the antibody |
IL306104A (en) * | 2016-09-14 | 2023-11-01 | Abbvie Biotherapeutics Inc | Antibodies against (CD27) PD-1 |
US10751414B2 (en) | 2016-09-19 | 2020-08-25 | Celgene Corporation | Methods of treating psoriasis using PD-1 binding antibodies |
EP3515943A4 (en) | 2016-09-19 | 2020-05-06 | Celgene Corporation | METHODS OF TREATING VITILIGO WITH PD-1 BINDING PROTEINS |
CN110023337B (zh) | 2016-10-11 | 2024-01-05 | 艾吉纳斯公司 | 抗lag-3抗体及其使用方法 |
WO2018081621A1 (en) | 2016-10-28 | 2018-05-03 | Bristol-Myers Squibb Company | Methods of treating urothelial carcinoma using an anti-pd-1 antibody |
US11117968B2 (en) | 2016-11-03 | 2021-09-14 | Bristol-Myers Squibb Company | Activatable anti-CTLA-4 antibodies and uses thereof |
AU2017373944B2 (en) | 2016-12-07 | 2022-02-03 | Agenus Inc. | Anti-CTLA-4 antibodies and methods of use thereof |
CA3046082A1 (en) | 2016-12-07 | 2018-06-14 | Agenus Inc. | Antibodies and methods of use thereof |
CN110366564B (zh) | 2016-12-23 | 2023-07-07 | 瑞美德生物医药科技有限公司 | 使用与程序性死亡1(pd-1)结合的抗体的免疫疗法 |
MA47265A (fr) | 2017-01-13 | 2019-11-20 | Agenus Inc | Récepteurs de lymphocytes t qui se lient à ny-eso-1 et méthodes d'utilisation de ces derniers |
CN108341871A (zh) * | 2017-01-24 | 2018-07-31 | 三生国健药业(上海)股份有限公司 | 抗pd-1单克隆抗体及其制备方法和应用 |
EP3589308A1 (en) | 2017-02-28 | 2020-01-08 | Sanofi | Therapeutic rna |
BR112019019795A2 (pt) | 2017-03-31 | 2020-04-22 | Bristol-Myers Squibb Company | métodos para tratar tumor |
EA201992350A1 (ru) | 2017-04-05 | 2020-03-23 | Симфоген А/С | Комбинированные лекарственные средства, нацеленные на pd-1, tim-3 и lag-3 |
TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
BR112019017241A2 (pt) | 2017-04-13 | 2020-04-14 | Agenus Inc | anticorpos anti-cd137 e métodos de uso dos mesmos |
EP3618863B1 (en) | 2017-05-01 | 2023-07-26 | Agenus Inc. | Anti-tigit antibodies and methods of use thereof |
HRP20231457T1 (hr) | 2017-05-30 | 2024-05-10 | Bristol-Myers Squibb Company | Liječenje lag-3-pozitivnih tumora |
EP4245375A3 (en) | 2017-05-30 | 2023-12-06 | Bristol-Myers Squibb Company | Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent |
WO2018222722A2 (en) | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Compositions comprising an anti-lag-3 antibody or an anti-lag-3 antibody and an anti-pd-1 or anti-pd-l1 antibody |
WO2018223040A1 (en) | 2017-06-01 | 2018-12-06 | Bristol-Myers Squibb Company | Methods of treating a tumor using an anti-pd-1 antibody |
JP2020522486A (ja) | 2017-06-01 | 2020-07-30 | サイトメックス セラピューティクス インコーポレイテッド | 活性化可能抗pdl1抗体、およびその使用方法 |
WO2019036855A1 (en) | 2017-08-21 | 2019-02-28 | Adagene Inc. | ANTI-CD137 MOLECULES AND THEIR USE |
SG11202001319QA (en) | 2017-09-04 | 2020-03-30 | Agenus Inc | T cell receptors that bind to mixed lineage leukemia (mll)-specific phosphopeptides and methods of use thereof |
CN111247169A (zh) | 2017-10-15 | 2020-06-05 | 百时美施贵宝公司 | 治疗肿瘤的方法 |
WO2019090330A1 (en) | 2017-11-06 | 2019-05-09 | Bristol-Myers Squibb Company | Methods of treating a tumor |
WO2019090263A1 (en) | 2017-11-06 | 2019-05-09 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
WO2019109238A1 (en) | 2017-12-05 | 2019-06-13 | Lyvgen Biopharma Co., Ltd. | Anti-cd137 antibodies and uses thereof |
KR20200120641A (ko) | 2018-01-15 | 2020-10-21 | 난징 레전드 바이오테크 씨오., 엘티디. | Pd-1에 대한 단일-도메인 항체 및 이의 변이체 |
EP3740506A1 (en) | 2018-01-16 | 2020-11-25 | Bristol-Myers Squibb Company | Methods of treating cancer with antibodies against tim3 |
EP3743061A1 (en) | 2018-01-22 | 2020-12-02 | Pascal Biosciences Inc. | Cannabinoids and derivatives for promoting immunogenicity of tumor and infected cells |
CN111629731A (zh) | 2018-01-22 | 2020-09-04 | 百时美施贵宝公司 | 治疗癌症的组合物和方法 |
WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
CN110269865A (zh) * | 2018-03-16 | 2019-09-24 | 山东大学 | 黑根霉胞外多糖在制备治疗诱发性结肠癌药物中的应用 |
EP3768713A2 (en) * | 2018-03-22 | 2021-01-27 | Keires AG | Antagonistic pd-1, pd-l1 and lag-3 binding proteins |
CN111886256A (zh) | 2018-03-23 | 2020-11-03 | 百时美施贵宝公司 | 抗mica和/或micb抗体及其用途 |
KR20200139724A (ko) | 2018-03-30 | 2020-12-14 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법 |
CN112292399A (zh) | 2018-04-04 | 2021-01-29 | 百时美施贵宝公司 | 抗cd27抗体及其用途 |
CN112074533A (zh) * | 2018-04-15 | 2020-12-11 | 信立泰(成都)生物技术有限公司 | 结合pd-1的抗体及其用途 |
TW202012430A (zh) | 2018-04-26 | 2020-04-01 | 美商艾吉納斯公司 | 熱休克蛋白質-結合之胜肽組成物及其使用方法 |
IL278400B2 (en) | 2018-05-07 | 2024-03-01 | Genmab As | Combination of an anti-PD-1 antibody and conjugation of a drug with an anti-TF antibody for use in the treatment of cancer |
KR20210010998A (ko) | 2018-05-17 | 2021-01-29 | 난징 리즈 바이오랩스 씨오., 엘티디. | 항체 결합 피디 1 및 그의 용도 |
US20210253614A1 (en) | 2018-05-31 | 2021-08-19 | Peloton Therapeutics, Inc. | Compositions and methods for inhibiting cd73 |
MX2020014091A (es) | 2018-06-23 | 2021-05-27 | Genentech Inc | Metodos para tratar el cancer de pulmon con un antagonista de fijacion al eje pd-1, un agente de platino y un inhibidor de la topoisomerasa ii. |
EP3823611A1 (en) | 2018-07-18 | 2021-05-26 | Genentech, Inc. | Methods of treating lung cancer with a pd-1 axis binding antagonist, an antimetabolite, and a platinum agent |
CA3107660A1 (en) | 2018-07-26 | 2020-01-30 | Bristol-Myers Squibb Company | Lag-3 combination therapy for the treatment of cancer |
MX2021002002A (es) | 2018-08-23 | 2021-05-31 | Seagen Inc | Anticuerpos anti inmunorreceptor de celulas t con dominios ig y motivo inhibidor inmunorreceptor basado en tirosina (tigit). |
EP3847154A1 (en) | 2018-09-03 | 2021-07-14 | F. Hoffmann-La Roche AG | Carboxamide and sulfonamide derivatives useful as tead modulators |
US20220177587A1 (en) | 2018-09-19 | 2022-06-09 | Alpine Immune Sciences, Inc. | Methods and uses of variant cd80 fusion proteins and related constructs |
CN112839962A (zh) | 2018-10-09 | 2021-05-25 | 百时美施贵宝公司 | 用于治疗癌症的抗mertk抗体 |
KR20210080437A (ko) | 2018-10-19 | 2021-06-30 | 브리스톨-마이어스 스큅 컴퍼니 | 흑색종을 위한 조합 요법 |
WO2020086724A1 (en) | 2018-10-23 | 2020-04-30 | Bristol-Myers Squibb Company | Methods of treating tumor |
JP6988769B2 (ja) * | 2018-11-08 | 2022-01-05 | 株式会社デンソー | 開閉体制御装置及びモータ |
KR20210092769A (ko) | 2018-11-16 | 2021-07-26 | 브리스톨-마이어스 스큅 컴퍼니 | 항-nkg2a 항체 및 그의 용도 |
EP3666905A1 (en) | 2018-12-11 | 2020-06-17 | Sanofi | E. coli positive for pks island as marker of positive response to anti-pd1 therapy in colorectal cancer |
EP3894401A2 (en) | 2018-12-11 | 2021-10-20 | Theravance Biopharma R&D IP, LLC | Naphthyridine and quinoline derivatives useful as alk5 inhibitors |
TW202043272A (zh) | 2019-01-14 | 2020-12-01 | 美商建南德克公司 | 使用pd-1軸結合拮抗劑及rna疫苗治療癌症之方法 |
SG11202107396RA (en) | 2019-01-21 | 2021-08-30 | Sanofi Sa | Therapeutic rna and anti-pd1 antibodies for advanced stage solid tumor cancers |
JP2022526960A (ja) | 2019-03-28 | 2022-05-27 | ブリストル-マイヤーズ スクイブ カンパニー | 腫瘍を処置する方法 |
WO2020198672A1 (en) | 2019-03-28 | 2020-10-01 | Bristol-Myers Squibb Company | Methods of treating tumor |
JP2022529154A (ja) | 2019-04-19 | 2022-06-17 | ジェネンテック, インコーポレイテッド | 抗mertk抗体及びその使用方法 |
EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
KR20220008306A (ko) | 2019-05-10 | 2022-01-20 | 리브젠 바이오파마 코., 엘티디. | 인간화 항-cd137 항체 및 이의 용도 |
EP3977132A1 (en) | 2019-05-30 | 2022-04-06 | Bristol-Myers Squibb Company | Cell localization signature and combination therapy |
EP3976832A1 (en) | 2019-05-30 | 2022-04-06 | Bristol-Myers Squibb Company | Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy |
US20220363760A1 (en) | 2019-05-30 | 2022-11-17 | Bristol-Myers Squibb Company | Multi-tumor gene signature for suitability to immuno-oncology therapy |
EP3998081A4 (en) | 2019-07-05 | 2023-07-12 | Ono Pharmaceutical Co., Ltd. | TREATMENT OF BLOOD CANCER WITH PD-1/CD3 DUAL SPECIFICITY PROTEIN |
KR20220042258A (ko) | 2019-07-15 | 2022-04-04 | 상하이 준스 바이오사이언스 컴퍼니 리미티드 | 항 tigit 항체 및 그의 응용 |
WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
EP4011918A4 (en) | 2019-08-08 | 2023-08-23 | ONO Pharmaceutical Co., Ltd. | DUAL SPECIFIC PROTEIN |
WO2021042019A1 (en) | 2019-08-30 | 2021-03-04 | Agenus Inc. | Anti-cd96 antibodies and methods of use thereof |
CN114450028A (zh) | 2019-09-22 | 2022-05-06 | 百时美施贵宝公司 | Lag-3拮抗剂治疗的定量空间剖析 |
AU2020353079A1 (en) | 2019-09-25 | 2022-04-14 | Bristol-Myers Squibb Company | Composite biomarker for cancer therapy |
EP4055392A1 (en) | 2019-11-05 | 2022-09-14 | Bristol-Myers Squibb Company | M-protein assays and uses thereof |
WO2021092221A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
WO2021092220A1 (en) | 2019-11-06 | 2021-05-14 | Bristol-Myers Squibb Company | Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy |
CN115942973A (zh) | 2019-11-08 | 2023-04-07 | 百时美施贵宝公司 | 用于黑色素瘤的lag-3拮抗剂疗法 |
CR20220207A (es) | 2019-11-13 | 2022-06-06 | Genentech Inc | Compuestos terapéuticos y métodos de uso |
US20220395553A1 (en) | 2019-11-14 | 2022-12-15 | Cohbar, Inc. | Cxcr4 antagonist peptides |
CN114728941A (zh) | 2019-11-22 | 2022-07-08 | 施万生物制药研发Ip有限责任公司 | 作为alk5抑制剂的经取代的1,5-萘啶或喹啉 |
BR112022009631A2 (pt) | 2019-12-19 | 2022-08-09 | Bristol Myers Squibb Co | Combinações de inibidores de dgk e antagonistas do ponto de checagem |
CA3168923A1 (en) | 2020-01-30 | 2021-08-05 | ONA Therapeutics S.L. | Combination therapy for treatment of cancer and cancer metastasis |
MX2022009391A (es) | 2020-01-31 | 2022-09-26 | Genentech Inc | Metodos para inducir linfocitos t especificos para neoepitopo con un antagonista de union al eje de pd-1 y una vacuna de arn. |
WO2021158938A1 (en) | 2020-02-06 | 2021-08-12 | Bristol-Myers Squibb Company | Il-10 and uses thereof |
BR112022016720A2 (pt) | 2020-03-06 | 2022-11-16 | Ona Therapeutics S L | Anticorpos anti-cd36 e seu uso para tratamento de câncer |
US20230119066A1 (en) | 2020-03-23 | 2023-04-20 | Bristol-Myers Squibb Company | Anti-ccr8 antibodies for treating cancer |
US11673879B2 (en) | 2020-03-31 | 2023-06-13 | Theravance Biopharma R&D Ip, Llc | Substituted pyrimidines and methods of use |
TW202214623A (zh) | 2020-06-10 | 2022-04-16 | 美商施萬生物製藥研發 Ip有限責任公司 | 結晶型alk5抑制劑及其用途 |
JP2023532768A (ja) | 2020-07-07 | 2023-07-31 | バイオエヌテック エスエー | Hpv陽性癌の治療用rna |
US11787775B2 (en) | 2020-07-24 | 2023-10-17 | Genentech, Inc. | Therapeutic compounds and methods of use |
BR112023002912A2 (pt) | 2020-08-27 | 2023-03-21 | Shanghai Junshi Biosciences Co Ltd | Uso de anticorpo anti-pd-1 no tratamento de carcinoma nasofaríngeo |
MX2023002332A (es) | 2020-08-28 | 2023-03-21 | Bristol Myers Squibb Co | Terapia con antagonistas del gen 3 de activacion de linfocitos (lag-3) para carcinoma hepatocelular. |
BR112023003154A2 (pt) * | 2020-08-28 | 2023-04-04 | Shanghai Junshi Biosciences Co Ltd | Uso de anticorpo anti-pd-1 e de fármaco anticancerígeno citotóxico no tratamento de câncer de pulmão de células não pequenas |
US20230303700A1 (en) | 2020-08-31 | 2023-09-28 | Bristol-Myers Squibb Company | Cell localization signature and immunotherapy |
US20230374064A1 (en) | 2020-10-05 | 2023-11-23 | Bristol-Myers Squibb Company | Methods for concentrating proteins |
WO2022086957A1 (en) | 2020-10-20 | 2022-04-28 | Genentech, Inc. | Peg-conjugated anti-mertk antibodies and methods of use |
EP4232019A1 (en) | 2020-10-23 | 2023-08-30 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for lung cancer |
WO2022093981A1 (en) | 2020-10-28 | 2022-05-05 | Genentech, Inc. | Combination therapy comprising ptpn22 inhibitors and pd-l1 binding antagonists |
KR20230098279A (ko) | 2020-10-28 | 2023-07-03 | 이케나 온콜로지, 인코포레이티드 | Pdx 억제제 또는 독소루비신과 ahr 억제제의 조합 |
US20220153842A1 (en) | 2020-11-04 | 2022-05-19 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates |
CA3196539A1 (en) | 2020-11-04 | 2022-05-12 | Chi-Chung Li | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
JP2023548069A (ja) | 2020-11-04 | 2023-11-15 | ジェネンテック, インコーポレイテッド | 抗cd20/抗cd3二重特異性抗体の皮下投薬 |
US20240024320A1 (en) | 2020-11-17 | 2024-01-25 | Seagen Inc. | Methods of treating cancer with a combination of tucatinib and an anti-pd-1/anti-pd-l1 antibody |
AU2021392630A1 (en) | 2020-12-02 | 2023-06-22 | Genentech, Inc. | Methods and compositions for neoadjuvant and adjuvant urothelial carcinoma therapy |
WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性rna |
PE20240820A1 (es) | 2020-12-28 | 2024-04-18 | Bristol Myers Squibb Co | Composiciones de anticuerpos y metodos de uso de los mismos |
EP4267172A1 (en) | 2020-12-28 | 2023-11-01 | Bristol-Myers Squibb Company | Subcutaneous administration of pd1/pd-l1 antibodies |
TW202304506A (zh) | 2021-03-25 | 2023-02-01 | 日商安斯泰來製藥公司 | 涉及抗claudin 18.2抗體的組合治療以治療癌症 |
BR112023019847A2 (pt) | 2021-03-29 | 2023-11-07 | Juno Therapeutics Inc | Métodos para dosagem e tratamento com uma combinação de uma terapia com inibidor de ponto de verificação e uma terapia com célula t car |
EP4314068A1 (en) | 2021-04-02 | 2024-02-07 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
EP4330436A1 (en) | 2021-04-30 | 2024-03-06 | Genentech, Inc. | Therapeutic and diagnostic methods and compositions for cancer |
KR20240005691A (ko) | 2021-04-30 | 2024-01-12 | 에프. 호프만-라 로슈 아게 | 항-cd20/항-cd3 이중특이적 항체 및 항-cd79b 항체 약물 접합체를 이용한 병용 치료를 위한 투약 |
WO2022242621A1 (zh) * | 2021-05-17 | 2022-11-24 | 上海君实生物医药科技股份有限公司 | 治疗完全切除黏膜黑色素瘤的患者的药物及方法 |
EP4340878A1 (en) * | 2021-05-20 | 2024-03-27 | Shanghai Junshi Biosciences Co., Ltd. | Use of anti-pd-1 antibody in combination with chemotherapy in treating esophageal cancer |
WO2022251359A1 (en) | 2021-05-26 | 2022-12-01 | Theravance Biopharma R&D Ip, Llc | Bicyclic inhibitors of alk5 and methods of use |
GB202107994D0 (en) | 2021-06-04 | 2021-07-21 | Kymab Ltd | Treatment of cancer |
WO2023279092A2 (en) | 2021-07-02 | 2023-01-05 | Genentech, Inc. | Methods and compositions for treating cancer |
EP4370552A1 (en) | 2021-07-13 | 2024-05-22 | BioNTech SE | Multispecific binding agents against cd40 and cd137 in combination therapy for cancer |
IL309120A (en) | 2021-07-28 | 2024-02-01 | Hoffmann La Roche | Methods and compositions for the treatment of cancer |
WO2023010094A2 (en) | 2021-07-28 | 2023-02-02 | Genentech, Inc. | Methods and compositions for treating cancer |
CA3226281A1 (en) | 2021-07-30 | 2023-02-02 | ONA Therapeutics S.L. | Anti-cd36 antibodies and their use to treat cancer |
WO2023051926A1 (en) | 2021-09-30 | 2023-04-06 | BioNTech SE | Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists |
WO2023056403A1 (en) | 2021-09-30 | 2023-04-06 | Genentech, Inc. | Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists |
WO2023057534A1 (en) | 2021-10-06 | 2023-04-13 | Genmab A/S | Multispecific binding agents against pd-l1 and cd137 in combination |
TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
AU2022375806A1 (en) | 2021-10-29 | 2023-12-14 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hematological cancer |
WO2023080900A1 (en) | 2021-11-05 | 2023-05-11 | Genentech, Inc. | Methods and compositions for classifying and treating kidney cancer |
WO2023083439A1 (en) | 2021-11-09 | 2023-05-19 | BioNTech SE | Tlr7 agonist and combinations for cancer treatment |
TW202332429A (zh) | 2021-11-24 | 2023-08-16 | 美商建南德克公司 | 治療性化合物及其使用方法 |
TW202340212A (zh) | 2021-11-24 | 2023-10-16 | 美商建南德克公司 | 治療性化合物及其使用方法 |
WO2023147371A1 (en) | 2022-01-26 | 2023-08-03 | Bristol-Myers Squibb Company | Combination therapy for hepatocellular carcinoma |
WO2023164638A1 (en) | 2022-02-25 | 2023-08-31 | Bristol-Myers Squibb Company | Combination therapy for colorectal carcinoma |
WO2023168404A1 (en) | 2022-03-04 | 2023-09-07 | Bristol-Myers Squibb Company | Methods of treating a tumor |
WO2023170606A1 (en) | 2022-03-08 | 2023-09-14 | Alentis Therapeutics Ag | Use of anti-claudin-1 antibodies to increase t cell availability |
WO2023178329A1 (en) | 2022-03-18 | 2023-09-21 | Bristol-Myers Squibb Company | Methods of isolating polypeptides |
WO2023191816A1 (en) | 2022-04-01 | 2023-10-05 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
WO2023196987A1 (en) | 2022-04-07 | 2023-10-12 | Bristol-Myers Squibb Company | Methods of treating tumor |
WO2023196964A1 (en) | 2022-04-08 | 2023-10-12 | Bristol-Myers Squibb Company | Machine learning identification, classification, and quantification of tertiary lymphoid structures |
WO2023219613A1 (en) | 2022-05-11 | 2023-11-16 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
WO2023218046A1 (en) | 2022-05-12 | 2023-11-16 | Genmab A/S | Binding agents capable of binding to cd27 in combination therapy |
WO2023235847A1 (en) | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
WO2023240058A2 (en) | 2022-06-07 | 2023-12-14 | Genentech, Inc. | Prognostic and therapeutic methods for cancer |
WO2024015897A1 (en) | 2022-07-13 | 2024-01-18 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
WO2024020432A1 (en) | 2022-07-19 | 2024-01-25 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
EP4310197A1 (en) | 2022-07-21 | 2024-01-24 | Fundación para la Investigación Biomédica del Hospital Universitario Puerta de Hierro Majadahonda | Method for identifying lung cancer patients for a combination treatment of immuno- and chemotherapy |
WO2024049949A1 (en) | 2022-09-01 | 2024-03-07 | Genentech, Inc. | Therapeutic and diagnostic methods for bladder cancer |
WO2024069009A1 (en) | 2022-09-30 | 2024-04-04 | Alentis Therapeutics Ag | Treatment of drug-resistant hepatocellular carcinoma |
WO2024077095A1 (en) | 2022-10-05 | 2024-04-11 | Genentech, Inc. | Methods and compositions for classifying and treating bladder cancer |
WO2024077166A1 (en) | 2022-10-05 | 2024-04-11 | Genentech, Inc. | Methods and compositions for classifying and treating lung cancer |
WO2024091991A1 (en) | 2022-10-25 | 2024-05-02 | Genentech, Inc. | Therapeutic and diagnostic methods for multiple myeloma |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1359937A (zh) * | 2000-12-20 | 2002-07-24 | 上海博德基因开发有限公司 | 一种新的多肽——人细胞程序性死亡因子Mch11.11和编码这种多肽的多核苷酸 |
US20090298703A1 (en) * | 2006-05-17 | 2009-12-03 | Gough Albert H | Method for Automated Tissue Analysis |
CN102298053A (zh) * | 2011-05-20 | 2011-12-28 | 中山大学肿瘤防治中心 | 原发性肝细胞肝癌术后复发风险评估的组合抗体试剂盒 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE207366T1 (de) * | 1993-12-24 | 2001-11-15 | Merck Patent Gmbh | Immunokonjugate |
EP2243493A1 (en) | 2002-07-03 | 2010-10-27 | Ono Pharmaceutical Co., Ltd. | Immunopotentiative composition |
SI2161336T1 (sl) * | 2005-05-09 | 2013-11-29 | Ono Pharmaceutical Co., Ltd. | Humana monoklonska protitelesa za programirano smrt 1 (PD-1) in postopki za zdravljenje raka ob uporabi anti-PD-1 protiteles samih ali v kombinaciji z drugimi imunoterapevtiki |
RU2429016C2 (ru) | 2006-05-31 | 2011-09-20 | Астеллас Фарма Инк. | Гуманизированное антитело против остеопонтина человека |
EP2535354B1 (en) * | 2007-06-18 | 2017-01-11 | Merck Sharp & Dohme B.V. | Antibodies to human programmed death receptor pd-1 |
US9243052B2 (en) * | 2007-08-17 | 2016-01-26 | Daniel Olive | Method for treating and diagnosing hematologic malignancies |
US8168757B2 (en) * | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
US8927697B2 (en) * | 2008-09-12 | 2015-01-06 | Isis Innovation Limited | PD-1 specific antibodies and uses thereof |
AU2009296392B2 (en) | 2008-09-26 | 2016-06-02 | Dana-Farber Cancer Institute, Inc. | Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor |
KR101050829B1 (ko) | 2008-10-02 | 2011-07-20 | 서울대학교산학협력단 | 항 pd-1 항체 또는 항 pd-l1 항체를 포함하는 항암제 |
US8993731B2 (en) | 2010-03-11 | 2015-03-31 | Ucb Biopharma Sprl | PD-1 antibody |
TW201134488A (en) * | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
CN104250302B (zh) | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
-
2013
- 2013-06-26 CN CN201310258289.2A patent/CN104250302B/zh active Active
-
2014
- 2014-02-26 SI SI201431678T patent/SI3026062T1/sl unknown
- 2014-02-26 ES ES14818708T patent/ES2822927T3/es active Active
- 2014-02-26 DK DK14818708.1T patent/DK3026062T3/da active
- 2014-02-26 PL PL14818708T patent/PL3026062T3/pl unknown
- 2014-02-26 EP EP20189272.6A patent/EP3845562A1/en active Pending
- 2014-02-26 WO PCT/CN2014/072574 patent/WO2014206107A1/zh active Application Filing
- 2014-02-26 JP JP2016522196A patent/JP6681327B2/ja active Active
- 2014-02-26 RU RU2016102176A patent/RU2663795C2/ru active
- 2014-02-26 US US14/392,360 patent/US10066013B2/en active Active
- 2014-02-26 MY MYPI2015704733A patent/MY176822A/en unknown
- 2014-02-26 BR BR112015031883-5A patent/BR112015031883A2/pt not_active Application Discontinuation
- 2014-02-26 EP EP14818708.1A patent/EP3026062B1/en active Active
- 2014-02-26 HU HUE14818708A patent/HUE052487T2/hu unknown
- 2014-02-26 PT PT148187081T patent/PT3026062T/pt unknown
-
2015
- 2015-12-18 PH PH12015502819A patent/PH12015502819A1/en unknown
-
2018
- 2018-07-25 US US16/045,363 patent/US10815302B2/en active Active
-
2020
- 2020-09-16 US US17/022,719 patent/US20210009688A1/en active Pending
- 2020-10-07 HR HRP20201600TT patent/HRP20201600T1/hr unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1359937A (zh) * | 2000-12-20 | 2002-07-24 | 上海博德基因开发有限公司 | 一种新的多肽——人细胞程序性死亡因子Mch11.11和编码这种多肽的多核苷酸 |
US20090298703A1 (en) * | 2006-05-17 | 2009-12-03 | Gough Albert H | Method for Automated Tissue Analysis |
CN102298053A (zh) * | 2011-05-20 | 2011-12-28 | 中山大学肿瘤防治中心 | 原发性肝细胞肝癌术后复发风险评估的组合抗体试剂盒 |
Non-Patent Citations (1)
Title |
---|
BERDOZ,J ET AL: "ACCESSION S52450", 《GENBANK DATABASE》 * |
Cited By (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108112254A (zh) * | 2015-03-13 | 2018-06-01 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
CN114702586A (zh) * | 2015-03-13 | 2022-07-05 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
CN108112254B (zh) * | 2015-03-13 | 2022-01-28 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
CN106699888A (zh) * | 2015-07-28 | 2017-05-24 | 钜川生物医药 | 一种pd-1抗体及其制备方法和应用 |
CN106699888B (zh) * | 2015-07-28 | 2020-11-06 | 上海昀怡健康科技发展有限公司 | 一种pd-1抗体及其制备方法和应用 |
CN106390115A (zh) * | 2015-07-29 | 2017-02-15 | 上海君实生物医药科技股份有限公司 | 一种人源化单克隆抗体的稳定制剂 |
AU2016307002B2 (en) * | 2015-08-10 | 2019-07-11 | Innovent Biologics (Suzhou) Co., Ltd. | PD-1 antibodies |
CN108473977B (zh) * | 2015-08-10 | 2019-03-26 | 信达生物制药(苏州)有限公司 | Pd-1抗体 |
WO2017024465A1 (en) * | 2015-08-10 | 2017-02-16 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
WO2017025016A1 (en) * | 2015-08-10 | 2017-02-16 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
CN108473977A (zh) * | 2015-08-10 | 2018-08-31 | 信达生物制药(苏州)有限公司 | Pd-1抗体 |
CN106432494B (zh) * | 2015-08-11 | 2021-07-16 | 广州誉衡生物科技有限公司 | 新型抗-pd-1抗体 |
CN106432494B9 (zh) * | 2015-08-11 | 2022-02-15 | 广州誉衡生物科技有限公司 | 新型抗-pd-1抗体 |
CN106432494A (zh) * | 2015-08-11 | 2017-02-22 | 哈尔滨誉衡药业股份有限公司 | 新型抗‑pd‑1抗体 |
US11643465B2 (en) | 2015-08-11 | 2023-05-09 | WuXi Biologics Ireland Limited | Anti-PD-1 antibodies |
US11008391B2 (en) | 2015-08-11 | 2021-05-18 | WuXi Biologics Ireland Limited | Anti-PD-1 antibodies |
CN108025069B (zh) * | 2015-09-03 | 2021-11-12 | 小野药品工业株式会社 | 使用变应素-1拮抗剂的癌症免疫增强剂 |
CN108025069A (zh) * | 2015-09-03 | 2018-05-11 | 小野药品工业株式会社 | 使用变应素-1拮抗剂的癌症免疫增强剂 |
WO2017058115A1 (en) | 2015-09-29 | 2017-04-06 | Asia Biotech Pte. Ltd. | Pd-1 antibodies and uses thereof |
EP3356416A4 (en) * | 2015-09-29 | 2019-04-10 | Asia Biotech Pte. Ltd. | ANTI-PD-1 ANTIBODIES AND USES THEREOF |
CN108601829A (zh) * | 2015-11-18 | 2018-09-28 | 礼进生物医药科技(上海)有限公司 | 抗pd-1抗体及其治疗用途 |
CN108601829B (zh) * | 2015-11-18 | 2020-04-24 | 礼进生物医药科技(上海)有限公司 | 抗pd-1抗体及其治疗用途 |
CN105566496A (zh) * | 2015-11-26 | 2016-05-11 | 大庆东竺明生物技术有限公司 | 阻断人程序性死亡因子1(pd-1)功能的单克隆抗体及其编码基因和应用 |
CN105566496B (zh) * | 2015-11-26 | 2019-04-02 | 大庆东竺明生物技术有限公司 | 阻断人程序性死亡因子1(pd-1)功能的单克隆抗体及其编码基因和应用 |
CN108779177B (zh) * | 2016-02-02 | 2021-09-24 | 信达生物制药(苏州)有限公司 | Pd-1抗体 |
CN108779177A (zh) * | 2016-02-02 | 2018-11-09 | 信达生物制药(苏州)有限公司 | Pd-1抗体 |
US10913801B2 (en) | 2016-02-02 | 2021-02-09 | Innovent Biologics (Suzhou) Co., Ltd. | PD-1 antibodies |
WO2017133540A1 (en) * | 2016-02-02 | 2017-08-10 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
WO2017132827A1 (en) * | 2016-02-02 | 2017-08-10 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
US11136413B2 (en) | 2016-03-04 | 2021-10-05 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | PDL-1 antibody, pharmaceutical composition thereof, and uses thereof |
US10465014B2 (en) | 2016-03-04 | 2019-11-05 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | PDL-1 antibody, pharmaceutical composition thereof, and uses thereof |
WO2017148424A1 (zh) * | 2016-03-04 | 2017-09-08 | 四川科伦博泰生物医药股份有限公司 | 一种pdl-1抗体、其药物组合物及其用途 |
CN105950715A (zh) * | 2016-04-27 | 2016-09-21 | 深圳市第三人民医院 | 检测δ42pd1的方法、引物及试剂盒 |
US11155626B2 (en) | 2016-05-20 | 2021-10-26 | Reyoung (Suzhou) Biology Science & Technology Co., Ltd | Anti-human PD-L1 humanized monoclonal antibody and application thereof |
US11059890B2 (en) | 2016-05-24 | 2021-07-13 | Reyoung (Suzhou) Biology Science & Technology Co., Ltd | Anti-human PD-1 humanized monoclonal antibody and application thereof |
WO2017201766A1 (zh) * | 2016-05-24 | 2017-11-30 | 瑞阳(苏州)生物科技有限公司 | 抗人pd-1人源化单克隆抗体及其应用 |
CN106085955B (zh) * | 2016-06-08 | 2019-09-10 | 中南大学 | 一种同时分离外周血t、b淋巴细胞的方法 |
CN106085955A (zh) * | 2016-06-08 | 2016-11-09 | 中南大学 | 一种同时分离外周血t、b淋巴细胞的方法 |
CN106046162A (zh) * | 2016-06-21 | 2016-10-26 | 大庆东竺明生物技术有限公司 | 抗人程序性死亡因子1(pd‑1)单克隆抗体的制备及应用 |
CN106046162B (zh) * | 2016-06-21 | 2019-04-02 | 大庆东竺明生物技术有限公司 | 抗人程序性死亡因子1(pd-1)单克隆抗体的制备及应用 |
WO2018036472A1 (zh) * | 2016-08-23 | 2018-03-01 | 中山康方生物医药有限公司 | 一种抗pd1单克隆抗体、其药物组合物及其用途 |
US11117967B2 (en) | 2016-09-14 | 2021-09-14 | Beijing Hanmi Pharm. Co., Ltd. | Antibody specifically binding to PD-1 and functional fragment thereof |
WO2018050027A1 (zh) * | 2016-09-14 | 2018-03-22 | 北京韩美药品有限公司 | 一种能够特异性地结合pd-1的抗体及其功能片段 |
CN109952316A (zh) * | 2016-09-14 | 2019-06-28 | 北京韩美药品有限公司 | 一种能够特异性地结合pd-1的抗体及其功能片段 |
US10465007B2 (en) | 2017-01-20 | 2019-11-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Anti-PD-1 antibodies and uses thereof |
WO2018133837A1 (en) * | 2017-01-20 | 2018-07-26 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Anti-pd-1 antibodies and uses thereof |
US11560430B2 (en) | 2017-01-20 | 2023-01-24 | Tayu Huaxia Biotech Medical Group Co., LTD | Anti-PD-1 antibodies and uses thereof |
US11345754B2 (en) | 2017-04-20 | 2022-05-31 | Acroimmune Biopharma Co., Ltd. | Monoclonal antibody antagonizing and inhibiting the binding of human PD-1 antigen to its ligand, preparation method therefor and application thereof |
CN107446048A (zh) * | 2017-09-13 | 2017-12-08 | 北京韩美药品有限公司 | 一种能够特异性地结合pd‑1的抗体及其功能片段 |
CN107446048B (zh) * | 2017-09-13 | 2021-03-30 | 北京韩美药品有限公司 | 一种能够特异性地结合pd-1的抗体及其功能片段 |
WO2019062755A1 (en) * | 2017-09-29 | 2019-04-04 | Wuxi Biologics (Shanghai) Co., Ltd. | BISPECIFIC ANTIBODIES DIRECTED AGAINST EGFR AND PD-1 |
CN109467603A (zh) * | 2017-11-14 | 2019-03-15 | 拜西欧斯(北京)生物技术有限公司 | 抗pd-1抗体及其制备方法和应用 |
CN108840932B (zh) * | 2018-04-28 | 2022-03-29 | 中国科学院微生物研究所 | 一种pd-1特异性抗体及其抗肿瘤应用 |
CN108840932A (zh) * | 2018-04-28 | 2018-11-20 | 中国科学院微生物研究所 | 一种pd-1特异性抗体及其抗肿瘤应用 |
CN109160949B (zh) * | 2018-07-23 | 2021-05-14 | 中国医学科学院血液病医院(血液学研究所) | 一种鼠抗人pd-1单克隆抗体及应用 |
CN109160949A (zh) * | 2018-07-23 | 2019-01-08 | 中国医学科学院血液病医院(血液学研究所) | 一种鼠抗人pd-1单克隆抗体及应用 |
CN110882385A (zh) * | 2018-09-07 | 2020-03-17 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗肿瘤中的用途 |
CN110882385B (zh) * | 2018-09-07 | 2021-07-09 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗肿瘤中的用途 |
CN112972675A (zh) * | 2018-09-07 | 2021-06-18 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗肿瘤中的用途 |
CN113166239A (zh) * | 2018-12-12 | 2021-07-23 | 上海君实生物医药科技股份有限公司 | 抗il-17a抗体及其应用 |
WO2020143749A1 (zh) | 2019-01-10 | 2020-07-16 | 迈威(上海)生物科技有限公司 | 重组抗人pd-1抗体及其应用 |
TWI843799B (zh) | 2019-02-03 | 2024-06-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗pd-1抗體、其抗原結合片段及醫藥用途 |
WO2020156509A1 (zh) * | 2019-02-03 | 2020-08-06 | 江苏恒瑞医药股份有限公司 | 抗pd-1抗体、其抗原结合片段及医药用途 |
RU2807484C2 (ru) * | 2019-02-03 | 2023-11-15 | Цзянсу Хэнжуй Медсин Ко., Лтд. | Антитело к pd-1, его антигенсвязывающий фрагмент и его фармацевтическое применение |
WO2020211804A1 (zh) * | 2019-04-17 | 2020-10-22 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在制备治疗实体瘤的药物中的用途 |
CN112292151A (zh) * | 2019-04-17 | 2021-01-29 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在制备治疗实体瘤的药物中的用途 |
CN114206931A (zh) * | 2019-09-30 | 2022-03-18 | 四川科伦博泰生物医药股份有限公司 | 抗pd-1抗体及其用途 |
CN114206931B (zh) * | 2019-09-30 | 2024-06-04 | 四川科伦博泰生物医药股份有限公司 | 抗pd-1抗体及其用途 |
WO2021063201A1 (zh) * | 2019-09-30 | 2021-04-08 | 四川科伦博泰生物医药股份有限公司 | 抗pd-1抗体及其用途 |
WO2021155840A1 (zh) * | 2020-02-07 | 2021-08-12 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗恶性肿瘤中的用途 |
CN115066260A (zh) * | 2020-02-07 | 2022-09-16 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗恶性肿瘤中的用途 |
WO2021160151A1 (zh) * | 2020-02-13 | 2021-08-19 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗肿瘤中的用途 |
WO2021160152A1 (zh) * | 2020-02-13 | 2021-08-19 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗神经内分泌瘤中的用途 |
WO2021180027A1 (zh) * | 2020-03-09 | 2021-09-16 | 和记黄埔医药(上海)有限公司 | 抗pd-1抗体和多受体酪氨酸激酶抑制剂的药物组合及其使用方法 |
WO2022012639A1 (zh) * | 2020-07-16 | 2022-01-20 | 和铂医药(上海)有限责任公司 | Pd-1抗原结合蛋白及其应用 |
WO2022042720A1 (en) * | 2020-08-31 | 2022-03-03 | Biosion Inc. | Pd-1 binding antibodies and uses thereof |
WO2022063314A1 (zh) * | 2020-09-28 | 2022-03-31 | 上海君实生物医药科技股份有限公司 | 靶向PD-1或PD-L1和TGF-β的双功能蛋白及其医药用途 |
CN112159476A (zh) * | 2020-10-10 | 2021-01-01 | 中国药科大学 | 一种用于多发性骨髓瘤的双特异性抗体及其应用 |
CN112159476B (zh) * | 2020-10-10 | 2022-08-02 | 中国药科大学 | 一种用于多发性骨髓瘤的双特异性抗体及其应用 |
CN113087796A (zh) * | 2021-04-02 | 2021-07-09 | 河南省肿瘤医院 | 一种抗pd-l1抗体及其应用 |
WO2022223006A1 (zh) * | 2021-04-22 | 2022-10-27 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体联合一线化疗治疗晚期非小细胞肺癌的用途 |
WO2023006055A1 (en) * | 2021-07-29 | 2023-02-02 | Shanghai Junshi Biosciences Co., Ltd. | Anti-pd-1 antibody pharmaceutical composition and use thereof |
Also Published As
Publication number | Publication date |
---|---|
RU2016102176A (ru) | 2017-07-31 |
CN104250302B (zh) | 2017-11-14 |
SI3026062T1 (sl) | 2020-12-31 |
US10066013B2 (en) | 2018-09-04 |
RU2663795C2 (ru) | 2018-08-09 |
HUE052487T2 (hu) | 2021-05-28 |
JP2016523265A (ja) | 2016-08-08 |
MY176822A (en) | 2020-08-24 |
EP3026062B1 (en) | 2020-08-05 |
EP3026062A4 (en) | 2017-08-16 |
EP3845562A1 (en) | 2021-07-07 |
BR112015031883A2 (pt) | 2018-02-14 |
ES2822927T3 (es) | 2021-05-05 |
DK3026062T3 (da) | 2020-10-12 |
WO2014206107A1 (zh) | 2014-12-31 |
US20190023782A1 (en) | 2019-01-24 |
HRP20201600T1 (hr) | 2021-03-05 |
JP6681327B2 (ja) | 2020-04-15 |
EP3026062A1 (en) | 2016-06-01 |
US20160272708A1 (en) | 2016-09-22 |
PH12015502819A1 (en) | 2016-03-21 |
US20210009688A1 (en) | 2021-01-14 |
PL3026062T3 (pl) | 2021-01-11 |
PT3026062T (pt) | 2020-10-13 |
US10815302B2 (en) | 2020-10-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104250302B (zh) | 抗pd‑1抗体及其应用 | |
CN105473615B (zh) | 抗-CD38抗体和与致弱干扰素α-2B的融合体 | |
CN102428103B (zh) | 抗light的人源化抗体及其使用 | |
CN113039205B (zh) | 靶向cll1的抗体及其应用 | |
WO2017201766A1 (zh) | 抗人pd-1人源化单克隆抗体及其应用 | |
JP2022548066A (ja) | 抗pd-l1単一ドメイン抗体ならびにその誘導体および使用 | |
CN108341871A (zh) | 抗pd-1单克隆抗体及其制备方法和应用 | |
CN108456251A (zh) | 抗pd-l1抗体及其应用 | |
CN109734813A (zh) | 一种嵌合抗原受体及其应用 | |
CN106986939A (zh) | 抗pd‑1和tem‑8双特异性抗体及其应用 | |
CN108712908A (zh) | 自交联抗体 | |
CN112500485B (zh) | 一种抗b7-h3抗体及其应用 | |
CN110396129A (zh) | 人源化cd19抗原结合单链抗体及其嵌合抗原受体、免疫细胞和应用 | |
CN109715661A (zh) | 抗干扰素-γ的抗体及其应用 | |
CN110305214A (zh) | 新型抗cd47抗体 | |
CN110172099A (zh) | 抗lag-3人源化单克隆抗体分子,抗原结合片段及其医药用途 | |
CN117321087A (zh) | 包含与细胞因子融合用于nk细胞衔接的nkp46结合位点、癌抗原结合位点的多特异性蛋白质 | |
CN108948193A (zh) | 针对tim-3的抗体分子,抗原结合片段及其医药用途 | |
WO2015172341A1 (zh) | 针对磷脂酰肌醇蛋白多糖-3和t细胞抗原的双特异性抗体 | |
WO2019192493A1 (zh) | 抗人lag-3单克隆抗体及其应用 | |
CN113354737B (zh) | 一种磷脂酰肌醇蛋白聚糖3抗体及其应用 | |
WO2021032174A1 (zh) | 一种抗cd47抗原结合蛋白及其应用 | |
CN115785269B (zh) | 抗pd-l1的抗体及其应用 | |
CN113087796B (zh) | 一种抗pd-l1抗体及其应用 | |
CN110272489A (zh) | 一种针对tim-3的全人源化抗体分子,抗原结合片段及其医药用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB02 | Change of applicant information | ||
CB02 | Change of applicant information |
Address after: 201203 Shanghai City 781 Cailun Road No. 6 Building Room 602 Applicant after: Shanghai Jun biomedical Polytron Technologies Inc Applicant after: SUZHOU JUNMENG BIOLOGICAL PHARMACEUTICAL CO., LTD. Address before: 201203 Shanghai Zhangjiang hi tech Park No. 781 Cailun Road, building 602 room 6 Applicant before: SHANGHAI JUNSHI BIOSCIENCES CO., LTD. Applicant before: SUZHOU JUNMENG BIOLOGICAL PHARMACEUTICAL CO., LTD. |
|
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20170712 Address after: 201203 Shanghai city Chinese (Shanghai) Free Trade Zone No. 781 Cailun Road, building 602 room 6 Applicant after: Shanghai Jun biomedical Polytron Technologies Inc Applicant after: SUZHOU JUNMENG BIOLOGICAL PHARMACEUTICAL CO., LTD. Applicant after: Shanghai Jun Shi Biological Engineering Co., Ltd. Address before: 201203 Shanghai City 781 Cailun Road No. 6 Building Room 602 Applicant before: Shanghai Jun biomedical Polytron Technologies Inc Applicant before: SUZHOU JUNMENG BIOLOGICAL PHARMACEUTICAL CO., LTD. |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20200331 Address after: 201203 13 / F, building 2, No. 36 and 58, Haiqu Road, Pudong New Area, Shanghai Co-patentee after: SHANGHAI JUNSHI BIOENGINEERING Co.,Ltd. Patentee after: SHANGHAI JUNSHI BIOSCIENCES Co.,Ltd. Address before: 201203 Shanghai city China (Shanghai) Free Trade Zone No. 781 Cailun Road, building 602 room 6 Co-patentee before: SUZHOU JUNMENG BIOSCIENCES Co.,Ltd. Patentee before: SHANGHAI JUNSHI BIOSCIENCES Co.,Ltd. Co-patentee before: SHANGHAI JUNSHI BIOENGINEERING Co.,Ltd. |