CN114206931A - 抗pd-1抗体及其用途 - Google Patents

抗pd-1抗体及其用途 Download PDF

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CN114206931A
CN114206931A CN202080055788.XA CN202080055788A CN114206931A CN 114206931 A CN114206931 A CN 114206931A CN 202080055788 A CN202080055788 A CN 202080055788A CN 114206931 A CN114206931 A CN 114206931A
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seq
sequence
antibody
cdr
antigen
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CN114206931B (zh
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刘登念
喻海旻
胡江江
刘汉杰
吴韬
肖亮
薛彤彤
王晶翼
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Sichuan Kelun Biotech Biopharmaceutical Co Ltd
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Abstract

本发明涉及疾病治疗领域，具体而言，本发明涉及抗PD‑1的抗体或其抗原结合片段，编码它们的核酸分子，制备它们的方法。本发明的抗PD‑1抗体或其抗原结合片段对PD‑1具有高特异性和高亲和力，能够有效阻断PD‑1/PD‑L1和PD‑1/PD‑L2的结合从而激活免疫系统，从而达到抑制肿瘤生长的效果。因此，本发明进一步涉及包含所述抗体或其抗原结合片段的药物组合物，以及其在制备药物中的用途，所述药物用于预防和/或治疗肿瘤、感染、或自身免疫性疾病。

Description

PCT国内申请，说明书已公开。

Claims (30)

  1. PCT国内申请，权利要求书已公开。
CN202080055788.XA 2019-09-30 2020-09-21 抗pd-1抗体及其用途 Active CN114206931B (zh)

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CN2019109399448 2019-09-30
CN201910939944 2019-09-30
PCT/CN2020/116417 WO2021063201A1 (zh) 2019-09-30 2020-09-21 抗pd-1抗体及其用途

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JP (1) JP2022550243A (zh)
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CN115785269A (zh) * 2022-11-01 2023-03-14 四川大学 抗pd-l1的抗体及其应用
WO2023186061A1 (zh) * 2022-03-31 2023-10-05 浙江特瑞思药业股份有限公司 抗pd-1纳米抗体、其应用及其治疗疾病的方法

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IL311738A (en) * 2021-09-29 2024-05-01 Akeso Biopharma Inc ANTI-LAG3 antibody, drug composition and use
WO2023198115A1 (en) * 2022-04-14 2023-10-19 Beigene Switzerland Gmbh Stable high concentration sodium chloride formulations containing pd-1 antibody and methods of use thereof

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WO2023186061A1 (zh) * 2022-03-31 2023-10-05 浙江特瑞思药业股份有限公司 抗pd-1纳米抗体、其应用及其治疗疾病的方法
CN115785269A (zh) * 2022-11-01 2023-03-14 四川大学 抗pd-l1的抗体及其应用
CN115785269B (zh) * 2022-11-01 2023-09-22 四川大学 抗pd-l1的抗体及其应用

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EP4039704A1 (en) 2022-08-10
EP4039704A4 (en) 2023-09-20
KR20220070201A (ko) 2022-05-30
CN114206931B (zh) 2024-06-04
WO2021063201A1 (zh) 2021-04-08
JP2022550243A (ja) 2022-12-01

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