JP2018529363A5 - - Google Patents
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- JP2018529363A5 JP2018529363A5 JP2018517183A JP2018517183A JP2018529363A5 JP 2018529363 A5 JP2018529363 A5 JP 2018529363A5 JP 2018517183 A JP2018517183 A JP 2018517183A JP 2018517183 A JP2018517183 A JP 2018517183A JP 2018529363 A5 JP2018529363 A5 JP 2018529363A5
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- JP
- Japan
- Prior art keywords
- protein
- chimeric protein
- heterologous chimeric
- item
- ox40l
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000037865 fusion proteins Human genes 0.000 claims description 77
- 108020001507 fusion proteins Proteins 0.000 claims description 77
- 102000004169 proteins and genes Human genes 0.000 claims description 27
- 108090000623 proteins and genes Proteins 0.000 claims description 27
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 26
- 108010042215 OX40 Ligand Proteins 0.000 claims description 17
- 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 claims description 17
- 239000008194 pharmaceutical composition Substances 0.000 claims description 17
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims description 12
- 208000023275 Autoimmune disease Diseases 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 239000013604 expression vector Substances 0.000 claims description 10
- 201000011510 cancer Diseases 0.000 claims description 9
- 230000028993 immune response Effects 0.000 claims description 9
- 108010029697 CD40 Ligand Proteins 0.000 claims description 7
- 102100032937 CD40 ligand Human genes 0.000 claims description 7
- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 claims description 7
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims description 7
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims description 5
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims description 5
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims description 4
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims description 4
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims description 4
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims description 4
- 101000597780 Mus musculus Tumor necrosis factor ligand superfamily member 18 Proteins 0.000 claims description 4
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims description 4
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims description 3
- 101000764622 Homo sapiens Transmembrane and immunoglobulin domain-containing protein 2 Proteins 0.000 claims description 3
- 102100026224 Transmembrane and immunoglobulin domain-containing protein 2 Human genes 0.000 claims description 3
- 102100024587 Tumor necrosis factor ligand superfamily member 15 Human genes 0.000 claims description 3
- 108090000138 Tumor necrosis factor ligand superfamily member 15 Proteins 0.000 claims description 3
- 102100035283 Tumor necrosis factor ligand superfamily member 18 Human genes 0.000 claims description 3
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000001506 immunosuppresive effect Effects 0.000 description 7
- 210000003162 effector t lymphocyte Anatomy 0.000 description 5
- 101710089372 Programmed cell death protein 1 Proteins 0.000 description 4
- 230000003308 immunostimulating effect Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 239000012636 effector Substances 0.000 description 2
- 210000003071 memory t lymphocyte Anatomy 0.000 description 2
- 108010082808 4-1BB Ligand Proteins 0.000 description 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108010017987 CD30 Ligand Proteins 0.000 description 1
- 102100025221 CD70 antigen Human genes 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 description 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 description 1
- 101100369992 Homo sapiens TNFSF10 gene Proteins 0.000 description 1
- 101000743493 Homo sapiens V-set and immunoglobulin domain-containing protein 8 Proteins 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 description 1
- 108700012411 TNFSF10 Proteins 0.000 description 1
- 102100032100 Tumor necrosis factor ligand superfamily member 8 Human genes 0.000 description 1
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 description 1
- 108091005906 Type I transmembrane proteins Proteins 0.000 description 1
- 108091005956 Type II transmembrane proteins Proteins 0.000 description 1
- 102100038355 V-set and immunoglobulin domain-containing protein 8 Human genes 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 210000003289 regulatory T cell Anatomy 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021126595A JP7303254B2 (ja) | 2015-10-01 | 2021-08-02 | Ｉ型及びｉｉ型細胞外ドメインを異種キメラタンパク質として連結する組成物及び方法 |
| JP2023102740A JP2023112132A (ja) | 2015-10-01 | 2023-06-22 | Ｉ型及びｉｉ型細胞外ドメインを異種キメラタンパク質として連結する組成物及び方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562235727P | 2015-10-01 | 2015-10-01 | |
| US62/235,727 | 2015-10-01 | ||
| US201562263313P | 2015-12-04 | 2015-12-04 | |
| US62/263,313 | 2015-12-04 | ||
| US201662372574P | 2016-08-09 | 2016-08-09 | |
| US62/372,574 | 2016-08-09 | ||
| PCT/US2016/054598 WO2017059168A1 (en) | 2015-10-01 | 2016-09-30 | Compositions and methods for adjoining type i and type ii extracellular domains as heterologous chimeric proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021126595A Division JP7303254B2 (ja) | 2015-10-01 | 2021-08-02 | Ｉ型及びｉｉ型細胞外ドメインを異種キメラタンパク質として連結する組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529363A JP2018529363A (ja) | 2018-10-11 |
| JP2018529363A5 true JP2018529363A5 (enExample) | 2019-11-07 |
| JP6981973B2 JP6981973B2 (ja) | 2021-12-17 |
Family
ID=58424302
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018517183A Active JP6981973B2 (ja) | 2015-10-01 | 2016-09-30 | Ｉ型及びｉｉ型細胞外ドメインを異種キメラタンパク質として連結する組成物及び方法 |
| JP2021126595A Active JP7303254B2 (ja) | 2015-10-01 | 2021-08-02 | Ｉ型及びｉｉ型細胞外ドメインを異種キメラタンパク質として連結する組成物及び方法 |
| JP2023102740A Pending JP2023112132A (ja) | 2015-10-01 | 2023-06-22 | Ｉ型及びｉｉ型細胞外ドメインを異種キメラタンパク質として連結する組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021126595A Active JP7303254B2 (ja) | 2015-10-01 | 2021-08-02 | Ｉ型及びｉｉ型細胞外ドメインを異種キメラタンパク質として連結する組成物及び方法 |
| JP2023102740A Pending JP2023112132A (ja) | 2015-10-01 | 2023-06-22 | Ｉ型及びｉｉ型細胞外ドメインを異種キメラタンパク質として連結する組成物及び方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (14) | US10183060B2 (enExample) |
| EP (2) | EP4183451B1 (enExample) |
| JP (3) | JP6981973B2 (enExample) |
| KR (1) | KR20180051651A (enExample) |
| CN (3) | CN116063566A (enExample) |
| AU (3) | AU2016331076B2 (enExample) |
| BR (1) | BR112018006578A2 (enExample) |
| CA (1) | CA2999280A1 (enExample) |
| IL (4) | IL303586B2 (enExample) |
| MX (2) | MX389750B (enExample) |
| PH (1) | PH12018500694A1 (enExample) |
| RU (2) | RU2766200C1 (enExample) |
| SA (1) | SA518391219B1 (enExample) |
| SG (5) | SG10201913576RA (enExample) |
| UA (1) | UA126549C2 (enExample) |
| WO (1) | WO2017059168A1 (enExample) |
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