EP4237000A4 - Two-domain multimeric fusion proteins - Google Patents

Two-domain multimeric fusion proteins

Info

Publication number
EP4237000A4
EP4237000A4 EP21887783.5A EP21887783A EP4237000A4 EP 4237000 A4 EP4237000 A4 EP 4237000A4 EP 21887783 A EP21887783 A EP 21887783A EP 4237000 A4 EP4237000 A4 EP 4237000A4
Authority
EP
European Patent Office
Prior art keywords
domain
fusion proteins
multimeric fusion
multimeric
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21887783.5A
Other languages
German (de)
French (fr)
Other versions
EP4237000A1 (en
Inventor
Elena Brin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Athae Bio Inc
Athae Bio Inc
Original Assignee
Athae Bio Inc
Athae Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Athae Bio Inc, Athae Bio Inc filed Critical Athae Bio Inc
Publication of EP4237000A1 publication Critical patent/EP4237000A1/en
Publication of EP4237000A4 publication Critical patent/EP4237000A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP21887783.5A 2020-11-02 2021-11-02 Two-domain multimeric fusion proteins Pending EP4237000A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063108789P 2020-11-02 2020-11-02
US202163246247P 2021-09-20 2021-09-20
US202163253501P 2021-10-07 2021-10-07
PCT/US2021/057777 WO2022094482A1 (en) 2020-11-02 2021-11-02 Two-domain multimeric fusion proteins

Publications (2)

Publication Number Publication Date
EP4237000A1 EP4237000A1 (en) 2023-09-06
EP4237000A4 true EP4237000A4 (en) 2024-09-18

Family

ID=81384425

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21887783.5A Pending EP4237000A4 (en) 2020-11-02 2021-11-02 Two-domain multimeric fusion proteins

Country Status (2)

Country Link
EP (1) EP4237000A4 (en)
WO (1) WO2022094482A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010105068A1 (en) * 2009-03-13 2010-09-16 The Trustees Of The University Of Pennsylvania Ox40/trail fusion proteins
WO2017059168A1 (en) * 2015-10-01 2017-04-06 Heat Biologics, Inc. Compositions and methods for adjoining type i and type ii extracellular domains as heterologous chimeric proteins
WO2017167672A1 (en) * 2016-03-29 2017-10-05 F. Hoffmann-La Roche Ag Trimeric costimulatory tnf family ligand-containing antigen binding molecules
WO2018157162A1 (en) * 2017-02-27 2018-08-30 Shattuck Labs, Inc. Tigit- and light-based chimeric proteins
US20180346549A1 (en) * 2017-05-31 2018-12-06 Clover Biopharmaceuticals, Inc. Method and Compositions for Producing Disulfide-Linked Trimeric TNF Family of Cytokines and Their Use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200291089A1 (en) * 2017-02-16 2020-09-17 Elstar Therapeutics, Inc. Multifunctional molecules comprising a trimeric ligand and uses thereof
EP3609527A4 (en) * 2017-03-29 2021-01-20 TDW Group Protein conjugates

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010105068A1 (en) * 2009-03-13 2010-09-16 The Trustees Of The University Of Pennsylvania Ox40/trail fusion proteins
WO2017059168A1 (en) * 2015-10-01 2017-04-06 Heat Biologics, Inc. Compositions and methods for adjoining type i and type ii extracellular domains as heterologous chimeric proteins
WO2017167672A1 (en) * 2016-03-29 2017-10-05 F. Hoffmann-La Roche Ag Trimeric costimulatory tnf family ligand-containing antigen binding molecules
WO2018157162A1 (en) * 2017-02-27 2018-08-30 Shattuck Labs, Inc. Tigit- and light-based chimeric proteins
US20180346549A1 (en) * 2017-05-31 2018-12-06 Clover Biopharmaceuticals, Inc. Method and Compositions for Producing Disulfide-Linked Trimeric TNF Family of Cytokines and Their Use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EDWIN BREMER: "Targeting of the Tumor Necrosis Factor Receptor Superfamily for Cancer Immunotherapy", ISRN ONCOLOGY, vol. 2013, 1 June 2013 (2013-06-01), pages 1 - 25, XP055360248, ISSN: 2356-7872, DOI: 10.1155/2013/371854 *
See also references of WO2022094482A1 *

Also Published As

Publication number Publication date
EP4237000A1 (en) 2023-09-06
WO2022094482A1 (en) 2022-05-05

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Legal Events

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Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20240816

RIC1 Information provided on ipc code assigned before grant

Ipc: C07K 14/705 20060101ALI20240809BHEP

Ipc: A61P 37/04 20060101ALI20240809BHEP

Ipc: C07K 14/525 20060101ALI20240809BHEP

Ipc: C07K 14/435 20060101ALI20240809BHEP

Ipc: C07K 14/52 20060101ALI20240809BHEP

Ipc: A61K 39/39 20060101AFI20240809BHEP