JP2020508066A5 - - Google Patents
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- JP2020508066A5 JP2020508066A5 JP2019546141A JP2019546141A JP2020508066A5 JP 2020508066 A5 JP2020508066 A5 JP 2020508066A5 JP 2019546141 A JP2019546141 A JP 2019546141A JP 2019546141 A JP2019546141 A JP 2019546141A JP 2020508066 A5 JP2020508066 A5 JP 2020508066A5
- Authority
- JP
- Japan
- Prior art keywords
- chimeric protein
- cells
- domain
- heterologous chimeric
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000037865 fusion proteins Human genes 0.000 claims description 104
- 108020001507 fusion proteins Proteins 0.000 claims description 104
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 25
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 25
- 206010028980 Neoplasm Diseases 0.000 claims description 20
- 108010042215 OX40 Ligand Proteins 0.000 claims description 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 19
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 16
- 239000003446 ligand Substances 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 14
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 14
- 210000004027 cell Anatomy 0.000 claims description 13
- 238000011282 treatment Methods 0.000 claims description 9
- 201000011510 cancer Diseases 0.000 claims description 8
- 208000027866 inflammatory disease Diseases 0.000 claims description 8
- 230000003993 interaction Effects 0.000 claims description 8
- 210000004881 tumor cell Anatomy 0.000 claims description 8
- 230000000259 anti-tumor effect Effects 0.000 claims description 6
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 230000001506 immunosuppresive effect Effects 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- 102000005962 receptors Human genes 0.000 claims description 6
- 108020003175 receptors Proteins 0.000 claims description 6
- 108010029697 CD40 Ligand Proteins 0.000 claims description 5
- 102100032937 CD40 ligand Human genes 0.000 claims description 5
- 230000000903 blocking effect Effects 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 230000011664 signaling Effects 0.000 claims description 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 210000003162 effector t lymphocyte Anatomy 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 230000004936 stimulating effect Effects 0.000 claims description 4
- 210000000225 synapse Anatomy 0.000 claims description 4
- 239000000556 agonist Substances 0.000 claims description 3
- 230000002829 reductive effect Effects 0.000 claims description 3
- 210000003289 regulatory T cell Anatomy 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 claims description 3
- 230000001988 toxicity Effects 0.000 claims description 3
- 231100000419 toxicity Toxicity 0.000 claims description 3
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 claims description 2
- 230000037453 T cell priming Effects 0.000 claims description 2
- 230000006052 T cell proliferation Effects 0.000 claims description 2
- 230000004913 activation Effects 0.000 claims description 2
- 239000005557 antagonist Substances 0.000 claims description 2
- 230000007423 decrease Effects 0.000 claims description 2
- 239000012636 effector Substances 0.000 claims description 2
- 230000002519 immonomodulatory effect Effects 0.000 claims description 2
- 210000002865 immune cell Anatomy 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 230000003308 immunostimulating effect Effects 0.000 claims description 2
- 210000005008 immunosuppressive cell Anatomy 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims description 2
- 230000004941 influx Effects 0.000 claims description 2
- 230000002601 intratumoral effect Effects 0.000 claims description 2
- 210000001165 lymph node Anatomy 0.000 claims description 2
- 230000000873 masking effect Effects 0.000 claims description 2
- 210000005259 peripheral blood Anatomy 0.000 claims description 2
- 239000011886 peripheral blood Substances 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 230000004044 response Effects 0.000 claims description 2
- 230000003248 secreting effect Effects 0.000 claims description 2
- 230000000638 stimulation Effects 0.000 claims description 2
- 230000004614 tumor growth Effects 0.000 claims description 2
- 230000005909 tumor killing Effects 0.000 claims description 2
- 101710102027 V-set and immunoglobulin domain-containing protein 8 Proteins 0.000 claims 13
- 102100038355 V-set and immunoglobulin domain-containing protein 8 Human genes 0.000 claims 13
- 102000004473 OX40 Ligand Human genes 0.000 claims 9
- 230000002045 lasting effect Effects 0.000 claims 2
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 14
- 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 description 10
- 239000003814 drug Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 108010082808 4-1BB Ligand Proteins 0.000 description 2
- 108010039471 Fas Ligand Protein Proteins 0.000 description 2
- 101100207070 Homo sapiens TNFSF8 gene Proteins 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- -1 LIGHT Proteins 0.000 description 2
- 101100207071 Mus musculus Tnfsf8 gene Proteins 0.000 description 2
- 101000597780 Mus musculus Tumor necrosis factor ligand superfamily member 18 Proteins 0.000 description 2
- 102100024587 Tumor necrosis factor ligand superfamily member 15 Human genes 0.000 description 2
- 108090000138 Tumor necrosis factor ligand superfamily member 15 Proteins 0.000 description 2
- 102100035283 Tumor necrosis factor ligand superfamily member 18 Human genes 0.000 description 2
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 2
- 102100032100 Tumor necrosis factor ligand superfamily member 8 Human genes 0.000 description 2
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 description 1
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 1
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 102000050320 human TNFRSF4 Human genes 0.000 description 1
- 102000057058 human VSIR Human genes 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023036738A JP2023071979A (ja) | 2017-02-27 | 2023-03-09 | Ｖｓｉｇ８ベースのキメラタンパク質 |
| JP2025020276A JP2025065443A (ja) | 2017-02-27 | 2025-02-10 | Ｖｓｉｇ８ベースのキメラタンパク質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762463999P | 2017-02-27 | 2017-02-27 | |
| US62/463,999 | 2017-02-27 | ||
| PCT/US2018/020038 WO2018157163A1 (en) | 2017-02-27 | 2018-02-27 | Vsig8-based chimeric proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023036738A Division JP2023071979A (ja) | 2017-02-27 | 2023-03-09 | Ｖｓｉｇ８ベースのキメラタンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020508066A JP2020508066A (ja) | 2020-03-19 |
| JP2020508066A5 true JP2020508066A5 (enExample) | 2021-04-08 |
| JP7244428B2 JP7244428B2 (ja) | 2023-03-22 |
Family
ID=63253418
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546141A Active JP7244428B2 (ja) | 2017-02-27 | 2018-02-27 | Ｖｓｉｇ８ベースのキメラタンパク質 |
| JP2023036738A Pending JP2023071979A (ja) | 2017-02-27 | 2023-03-09 | Ｖｓｉｇ８ベースのキメラタンパク質 |
| JP2025020276A Withdrawn JP2025065443A (ja) | 2017-02-27 | 2025-02-10 | Ｖｓｉｇ８ベースのキメラタンパク質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023036738A Pending JP2023071979A (ja) | 2017-02-27 | 2023-03-09 | Ｖｓｉｇ８ベースのキメラタンパク質 |
| JP2025020276A Withdrawn JP2025065443A (ja) | 2017-02-27 | 2025-02-10 | Ｖｓｉｇ８ベースのキメラタンパク質 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US11192933B2 (enExample) |
| EP (2) | EP3585410B9 (enExample) |
| JP (3) | JP7244428B2 (enExample) |
| CN (2) | CN118184797A (enExample) |
| AU (1) | AU2018224852B2 (enExample) |
| CA (1) | CA3054130A1 (enExample) |
| IL (1) | IL268170A (enExample) |
| WO (1) | WO2018157163A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113747947A (zh) * | 2019-02-28 | 2021-12-03 | 沙塔克实验室有限公司 | 组合疗法 |
| US20220259281A1 (en) * | 2019-06-21 | 2022-08-18 | Shattuck Labs, Inc. | Chimeric protein expressing t-cells |
| JP2024527902A (ja) * | 2021-07-26 | 2024-07-26 | カイト ファーマ インコーポレイテッド | Ｄｎｖｓｉｇ３及びｄｎｖｓｉｇ８受容体並びにその使用方法 |
| WO2024123812A1 (en) | 2022-12-05 | 2024-06-13 | Shattuck Labs, Inc. | Fusion proteins for the treatment of cardiometabolic diseases |
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-
2018
- 2018-02-27 JP JP2019546141A patent/JP7244428B2/ja active Active
- 2018-02-27 CA CA3054130A patent/CA3054130A1/en active Pending
- 2018-02-27 US US16/484,854 patent/US11192933B2/en active Active
- 2018-02-27 EP EP18757138.5A patent/EP3585410B9/en active Active
- 2018-02-27 EP EP23176998.5A patent/EP4249503A3/en active Pending
- 2018-02-27 CN CN202410306323.7A patent/CN118184797A/zh active Pending
- 2018-02-27 AU AU2018224852A patent/AU2018224852B2/en not_active Expired - Fee Related
- 2018-02-27 WO PCT/US2018/020038 patent/WO2018157163A1/en not_active Ceased
- 2018-02-27 CN CN201880010430.8A patent/CN110290798B/zh active Active
-
2019
- 2019-07-18 IL IL268170A patent/IL268170A/en unknown
- 2019-10-28 US US16/665,803 patent/US11192934B2/en active Active
-
2021
- 2021-11-01 US US17/516,006 patent/US11834488B2/en active Active
-
2023
- 2023-03-09 JP JP2023036738A patent/JP2023071979A/ja active Pending
- 2023-10-24 US US18/492,982 patent/US20240067698A1/en not_active Abandoned
-
2025
- 2025-02-10 JP JP2025020276A patent/JP2025065443A/ja not_active Withdrawn
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