JP2020508068A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020508068A5 JP2020508068A5 JP2019546149A JP2019546149A JP2020508068A5 JP 2020508068 A5 JP2020508068 A5 JP 2020508068A5 JP 2019546149 A JP2019546149 A JP 2019546149A JP 2019546149 A JP2019546149 A JP 2019546149A JP 2020508068 A5 JP2020508068 A5 JP 2020508068A5
- Authority
- JP
- Japan
- Prior art keywords
- type
- domain
- amino acid
- acid sequence
- chimeric protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023062366A JP7620045B2 (ja) | 2017-02-27 | 2023-04-06 | Ｔｉｇｉｔ及びｌｉｇｈｔベースのキメラタンパク質 |
| JP2025003769A JP2025061180A (ja) | 2017-02-27 | 2025-01-09 | Ｔｉｇｉｔ及びｌｉｇｈｔベースのキメラタンパク質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762464002P | 2017-02-27 | 2017-02-27 | |
| US62/464,002 | 2017-02-27 | ||
| PCT/US2018/020037 WO2018157162A1 (en) | 2017-02-27 | 2018-02-27 | Tigit- and light-based chimeric proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023062366A Division JP7620045B2 (ja) | 2017-02-27 | 2023-04-06 | Ｔｉｇｉｔ及びｌｉｇｈｔベースのキメラタンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020508068A JP2020508068A (ja) | 2020-03-19 |
| JP2020508068A5 true JP2020508068A5 (enExample) | 2021-04-08 |
| JP7260477B2 JP7260477B2 (ja) | 2023-04-18 |
Family
ID=63253416
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546144A Expired - Fee Related JP7128195B2 (ja) | 2017-02-27 | 2018-02-27 | 細胞外ドメインベースのキメラタンパク質の製造方法及び使用方法 |
| JP2019546149A Active JP7260477B2 (ja) | 2017-02-27 | 2018-02-27 | Ｔｉｇｉｔ及びｌｉｇｈｔベースのキメラタンパク質 |
| JP2022130749A Pending JP2022159510A (ja) | 2017-02-27 | 2022-08-18 | 細胞外ドメインベースのキメラタンパク質の製造方法及び使用方法 |
| JP2023062366A Active JP7620045B2 (ja) | 2017-02-27 | 2023-04-06 | Ｔｉｇｉｔ及びｌｉｇｈｔベースのキメラタンパク質 |
| JP2025003769A Withdrawn JP2025061180A (ja) | 2017-02-27 | 2025-01-09 | Ｔｉｇｉｔ及びｌｉｇｈｔベースのキメラタンパク質 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546144A Expired - Fee Related JP7128195B2 (ja) | 2017-02-27 | 2018-02-27 | 細胞外ドメインベースのキメラタンパク質の製造方法及び使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022130749A Pending JP2022159510A (ja) | 2017-02-27 | 2022-08-18 | 細胞外ドメインベースのキメラタンパク質の製造方法及び使用方法 |
| JP2023062366A Active JP7620045B2 (ja) | 2017-02-27 | 2023-04-06 | Ｔｉｇｉｔ及びｌｉｇｈｔベースのキメラタンパク質 |
| JP2025003769A Withdrawn JP2025061180A (ja) | 2017-02-27 | 2025-01-09 | Ｔｉｇｉｔ及びｌｉｇｈｔベースのキメラタンパク質 |
Country Status (15)
| Country | Link |
|---|---|
| US (8) | US11332509B2 (enExample) |
| EP (2) | EP3585425A4 (enExample) |
| JP (5) | JP7128195B2 (enExample) |
| KR (1) | KR102745835B1 (enExample) |
| CN (3) | CN118994414A (enExample) |
| AU (2) | AU2018223821B2 (enExample) |
| BR (1) | BR112019017298A2 (enExample) |
| CA (2) | CA3054127A1 (enExample) |
| IL (2) | IL268198B2 (enExample) |
| MX (1) | MX2019009812A (enExample) |
| MY (1) | MY207687A (enExample) |
| PH (1) | PH12019501533A1 (enExample) |
| SG (1) | SG11201906465YA (enExample) |
| WO (2) | WO2018157162A1 (enExample) |
| ZA (1) | ZA201905488B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL268198B2 (en) | 2017-02-27 | 2024-10-01 | Shattuck Labs Inc | Tigit- and light-based chimeric proteins |
| US12134790B2 (en) | 2017-09-27 | 2024-11-05 | Inozyme Pharma, Inc. | Methods of improving cardiovascular function and treating cardiovascular disease using a recombinant ectonucleotide pyrophosphatase phosphodiesterase (NPP1) |
| CN112566650A (zh) * | 2018-06-21 | 2021-03-26 | 沙塔克实验室有限公司 | 异二聚体蛋白及其用途 |
| MX2021002292A (es) | 2018-08-29 | 2021-05-27 | Shattuck Labs Inc | Terapias de combinacion que comprenden proteinas quimericas basadas en sirp alfa. |
| AU2019328305A1 (en) * | 2018-08-29 | 2021-03-04 | Shattuck Labs, Inc. | Combination therapies comprising tim-3-based chimeric proteins |
| US20210324041A1 (en) * | 2018-08-29 | 2021-10-21 | Shattuck Labs, Inc. | Combination therapies |
| EP3844280A4 (en) * | 2018-08-31 | 2022-09-14 | Yale University | ENPP1 POLYPEPTIDES AND METHODS OF USE |
| CA3112788A1 (en) * | 2018-09-05 | 2020-03-12 | Arizona Board Of Regents On Behalf Of Arizona State University | Oncolytic virus platform to treat hematological cancer |
| IL283165B2 (en) | 2018-11-21 | 2024-12-01 | Mayo Found Medical Education & Res | Adenoviruses and methods for using adenoviruses |
| CN113747947A (zh) * | 2019-02-28 | 2021-12-03 | 沙塔克实验室有限公司 | 组合疗法 |
| MX2021010577A (es) * | 2019-04-29 | 2021-10-13 | Mayo Found Medical Education & Res | Compuestos de union a pd-l1 multivalentes para tratar cancer. |
| CN112111437B (zh) * | 2020-05-25 | 2023-09-05 | 江南大学 | 2’-岩藻糖基乳糖产量提高的重组枯草芽孢杆菌及其构建方法 |
| TW202210514A (zh) * | 2020-06-02 | 2022-03-16 | 美商阿克思生物科學有限公司 | 針對tigit的抗體 |
| EP4162036A1 (en) | 2020-06-09 | 2023-04-12 | Inozyme Pharma, Inc. | Soluble enpp1 or enpp3 proteins and uses thereof |
| WO2021257124A1 (en) | 2020-06-18 | 2021-12-23 | Genentech, Inc. | Treatment with anti-tigit antibodies and pd-1 axis binding antagonists |
| TW202216778A (zh) | 2020-07-15 | 2022-05-01 | 美商安進公司 | Ｔｉｇｉｔ及ｃｄ１１２ｒ阻斷 |
| CN111808800B (zh) * | 2020-07-20 | 2022-08-26 | 中南大学湘雅二医院 | 一种体外诱导免疫抑制性髓系抑制细胞及其制备和应用 |
| IL301454A (en) * | 2020-09-17 | 2023-05-01 | Shattuck Labs Inc | Clinical dosing of SIRP1A chimeric protein |
| EP4237000A4 (en) * | 2020-11-02 | 2024-09-18 | Athae Bio, Inc. | TWO-DOMAIN MULTIMERIC FUSION PROTEINS |
| AU2021390545A1 (en) * | 2020-12-03 | 2023-07-06 | Shattuck Labs, Inc. | Methods of treating cancer using tigit-and light-based chimeric proteins |
| CN116897202A (zh) * | 2021-02-24 | 2023-10-17 | 科济生物医药（上海）有限公司 | Tigit工程化细胞及其组合物 |
| CN115260312B (zh) * | 2021-04-30 | 2025-02-14 | 保诺科技（北京）有限公司 | 结合ox40的抗体或抗原结合片段 |
| CN118871463A (zh) | 2021-07-28 | 2024-10-29 | 基因泰克公司 | 用于治疗癌症的方法和组合物 |
| WO2023056403A1 (en) | 2021-09-30 | 2023-04-06 | Genentech, Inc. | Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists |
| CN115960247A (zh) * | 2021-10-13 | 2023-04-14 | 苏州科锐迈德生物医药科技有限公司 | 基于t7rna聚合酶的融合多肽及其制备方法、用途 |
| WO2023077156A1 (en) * | 2021-11-01 | 2023-05-04 | Shattuck Labs, Inc. | Modified mrna therapeutics |
| CN114209815B (zh) * | 2021-11-22 | 2024-04-26 | 山东大学 | 一种药物组合物及其制备方法和应用 |
| WO2023105281A1 (en) * | 2021-12-11 | 2023-06-15 | Fundaciò Privada Institut De Recerca De La Sida-Caixa | Soluble tigit recombinant proteins |
| CN115490771B (zh) * | 2021-12-24 | 2026-04-28 | 合肥天港免疫药物有限公司 | 重组抗体及其应用 |
| CN114196691B (zh) * | 2021-12-28 | 2023-08-11 | 重庆澳龙生物制品有限公司 | 一种制备防治牛、羊棘球蚴病多表位重组疫苗的基因、蛋白质、疫苗和应用 |
| JP2025523387A (ja) | 2022-06-07 | 2025-07-23 | ジェネンテック， インコーポレイテッド | 抗ｐｄ－ｌ１アンタゴニストおよび抗ｔｉｇｉｔアンタゴニスト抗体を含む、肺がん治療の有効性を判定するための方法 |
| CN117624375A (zh) * | 2022-08-30 | 2024-03-01 | 北京卡替医疗技术有限公司 | 增强受体、表达增强受体的免疫细胞及其用途 |
| CN116350748A (zh) * | 2022-11-01 | 2023-06-30 | 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) | Tigit融合蛋白在制备用于治疗系统性红斑狼疮药物中的应用 |
| WO2024123812A1 (en) | 2022-12-05 | 2024-06-13 | Shattuck Labs, Inc. | Fusion proteins for the treatment of cardiometabolic diseases |
| CN116041542B (zh) * | 2022-12-06 | 2026-02-17 | 上海恩凯细胞技术有限公司 | 逆转肿瘤微环境抑制性信号的nk细胞制备方法及应用 |
| CN116037072B (zh) * | 2023-02-24 | 2025-01-03 | 宁夏医科大学 | 一种血清抗体亲和分离材料的制备方法与应用 |
| CN116925236B (zh) * | 2023-05-12 | 2024-06-04 | 上海恩凯细胞技术有限公司 | 嵌合转换受体及其应用 |
| AU2024314312A1 (en) * | 2023-06-22 | 2025-10-30 | Fbd Biologics Limited | Multi-targeting protein complex and methods of use thereof |
| CN116982600B (zh) * | 2023-09-14 | 2025-11-18 | 江苏集萃药康生物科技股份有限公司 | 一种cd69人源化小鼠模型的构建方法及其应用 |
| CN119930791A (zh) * | 2023-11-02 | 2025-05-06 | 重庆精准生物技术有限公司 | 特异性tigit肽段 |
| CN122295374A (zh) * | 2023-12-29 | 2026-06-26 | 沈阳三生制药有限责任公司 | 一种tigit多肽及tigit/ctla4融合蛋白 |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5844095A (en) | 1991-06-27 | 1998-12-01 | Bristol-Myers Squibb Company | CTLA4 Ig fusion proteins |
| DK0897983T3 (da) | 1991-10-25 | 2003-08-11 | Immunex Corp | Antistoffer mod CD40-L |
| EP1908780B1 (en) | 2000-01-03 | 2012-08-15 | The Trustees Of The University Of Pennsylvania | Novel chimeric proteins and methods for using the same |
| US20110041190A1 (en) | 2002-10-31 | 2011-02-17 | Tykocinski Mark L | Novel chimeric proteins |
| US7696168B2 (en) * | 2000-04-21 | 2010-04-13 | Tufts Medical Center, Inc. | G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same |
| EP1456652A4 (en) | 2001-11-13 | 2005-11-02 | Dana Farber Cancer Inst Inc | IMMUNOCELL ACTIVATION MODULATING SUBSTANCES AND USE METHOD THEREFOR |
| JP2008500013A (ja) | 2003-10-03 | 2008-01-10 | ザ ブライハム アンド ウイメンズ ホスピタル，インコーポレイテッド | Ｔｉｍ−３ポリペプチド |
| BRPI0406605B8 (pt) | 2003-11-13 | 2021-05-25 | Hanmi Holdings Co Ltd | conjugado de proteína, método para a preparação do mesmo e composição farmacêutica para intensificar a duração e estabilidade in vivo de um polipeptídeo fisiologicamente ativo |
| JP2006345852A (ja) | 2005-06-16 | 2006-12-28 | Virxsys Corp | 抗体複合体 |
| WO2007133811A2 (en) | 2006-05-15 | 2007-11-22 | Viral Logic Systems Technology Corp. | Cd47 related compositions and methods for treating immunological diseases and disorders |
| CN105837690A (zh) | 2006-06-12 | 2016-08-10 | 新兴产品开发西雅图有限公司 | 具有效应功能的单链多价结合蛋白 |
| CA2656923A1 (en) | 2006-06-21 | 2007-12-27 | Genentech, Inc. | Crystal structures of ox40l and ox40l complexed with ox40 receptor |
| US20100150931A1 (en) | 2006-11-22 | 2010-06-17 | Centre Hospitalier De L'universite De Montreal | Novel receptor for cd40l and uses thereof |
| WO2008144029A1 (en) | 2007-05-14 | 2008-11-27 | The University Of Chicago | Antibody-light fusion products for cancer therapeutics |
| PT3056515T (pt) | 2008-01-15 | 2019-07-19 | Univ Leland Stanford Junior | Métodos para manipulação da fagocitose mediada por cd47 |
| US20090226435A1 (en) | 2008-03-08 | 2009-09-10 | Sanjay Khare | Engineered fusion molecules immunotherapy in cancer and inflammatory diseases |
| EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
| CN102137869B (zh) | 2008-06-30 | 2018-07-06 | 宾夕法尼亚大学 | Fn14/TRAIL融合蛋白 |
| JP2011526794A (ja) | 2008-07-02 | 2011-10-20 | エマージェント プロダクト デベロップメント シアトル， エルエルシー | ＴＧＦ−βアンタゴニスト多重標的結合性分子 |
| PL2604693T3 (pl) | 2008-07-21 | 2016-09-30 | Jednołańcuchowe cząsteczki TNFSF | |
| US8183207B2 (en) | 2008-11-26 | 2012-05-22 | Five Prime Therapeutics, Inc. | Treatment of osteolytic disorders and cancer using CSF1R extracellular domain fusion molecules |
| US8080246B2 (en) | 2008-11-26 | 2011-12-20 | Five Prime Therapeutics, Inc. | Colony stimulating factor 1 receptor (CSF1R) extracellular domain fusion molecules |
| BRPI0923442A2 (pt) | 2008-12-19 | 2016-01-12 | Novartis Ag | polipeptídeos solúveis para uso em tratamento de distúrbio autoimunes e inflamatórios. |
| US9221895B2 (en) | 2009-03-13 | 2015-12-29 | The Trustees Of The University Of Pennsylvania | OX40/TRAIL fusion proteins |
| US8993524B2 (en) | 2010-03-05 | 2015-03-31 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
| EP2621514B1 (en) | 2010-09-28 | 2016-09-21 | KAHR Medical (2005) Ltd | Compositions and methods for treatment of hematological malignancies |
| CN103261217B (zh) | 2010-11-11 | 2017-04-26 | 港大科桥有限公司 | 可溶性 pd‑1变体、融合构建体及其用途 |
| EP3415528B1 (en) | 2011-04-13 | 2021-05-26 | Bristol-Myers Squibb Company | Fc fusion proteins comprising novel linkers or arrangements |
| WO2012162565A2 (en) | 2011-05-25 | 2012-11-29 | Cel-Sci Corporation | Method for inducing an immune response for treatment of cancer and autoimmune diseases or conditions |
| CN102850458B (zh) | 2011-06-28 | 2014-10-01 | 华博生物医药技术（上海）有限公司 | 新型重组双功能融合蛋白及其制法和用途 |
| MX2014001222A (es) | 2011-07-29 | 2014-09-15 | Univ Pennsylvania | Receptores coestimuladores de cambio. |
| US9828432B2 (en) | 2012-02-06 | 2017-11-28 | Providence Health & Services—Oregon | Cancer treatment and monitoring methods using OX40 agonists |
| PL3489254T3 (pl) | 2012-04-30 | 2023-01-30 | Biocon Limited | Ukierunkowujące/immunomodulujące białko fuzyjne i sposoby jego otrzymywania |
| EP2850106B1 (en) | 2012-05-18 | 2022-03-23 | Aptevo Research and Development LLC | Bispecific scfv immunofusion (bif) binding to cd123 and cd3 |
| CN112587671A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| ME03550B (me) | 2012-12-17 | 2020-07-20 | Trillium Therapeutics Inc | Lečenje cd47+ obolelih ćelija sa sirp alfa-fc fuzijama |
| EP2941438A1 (en) | 2013-01-01 | 2015-11-11 | Kahr Medical Ltd. | Stable form of signal converting protein fusion proteins, and methods of use and preparation thereof |
| EP2948475A2 (en) | 2013-01-23 | 2015-12-02 | AbbVie Inc. | Methods and compositions for modulating an immune response |
| WO2014121093A1 (en) | 2013-01-31 | 2014-08-07 | Thomas Jefferson University | Fusion proteins that facilitate cancer cell destruction |
| WO2015116178A1 (en) | 2014-01-31 | 2015-08-06 | Thomas Jefferson University | Fusion proteins for modulating regulatory and effector t cells |
| EP2951199A4 (en) | 2013-01-31 | 2016-07-20 | Univ Jefferson | Fusion proteins for the modulation of regulatory and effector T cells |
| EP2951209A4 (en) | 2013-01-31 | 2016-06-22 | Univ Jefferson | CD40 OX40 AGONIST FUSION PROTEIN AND USES THEREOF |
| EP2950814A4 (en) | 2013-01-31 | 2016-06-08 | Univ Jefferson | FUSION PROTEINS BASED ON PD-L1 AND PD-L2 AND USES THEREOF |
| IL298125A (en) | 2013-02-26 | 2023-01-01 | Memorial Sloan Kettering Cancer Center | Preparations and methods for immunotherapy |
| MY186864A (en) | 2013-03-12 | 2021-08-26 | Biocon Ltd | Fusion immunomodulatory proteins and methods for making same |
| SMT202300039T1 (it) | 2013-09-13 | 2023-03-17 | Beigene Switzerland Gmbh | Anticorpi anti-pd1 e loro uso come terapia e per diagnostica |
| US10144770B2 (en) * | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| US10196435B2 (en) | 2013-11-18 | 2019-02-05 | University Of Southern California | OX40L fusion protein for the immunotherapy of tumors of veterinary animals |
| MX2016007965A (es) | 2013-12-17 | 2016-10-28 | Genentech Inc | Terapia de combinacion que comprende agonistas de union a ox40 y antagonistas de union al eje pd-1. |
| AU2015205530B8 (en) | 2014-01-13 | 2019-09-19 | Pieris Pharmaceuticals Gmbh | Multi-specific polypeptide useful for localized tumor immunomodulation |
| JP2017504327A (ja) | 2014-01-14 | 2017-02-09 | カイマブ・リミテッド | 抗ｌｉｇｈｔ抗体 |
| WO2015112534A2 (en) | 2014-01-21 | 2015-07-30 | Medimmune, Llc | Compositions and methods for modulating and redirecting immune responses |
| JP6355032B2 (ja) | 2014-03-24 | 2018-07-11 | イミューンオンコ バイオファーマシューティカルズ （シャンハイ） カンパニー リミテッド | 新規組換え二機能性融合タンパク質、それらの調製および使用 |
| CN106456734A (zh) | 2014-05-29 | 2017-02-22 | 免疫医疗有限责任公司 | Ox40l融合蛋白及其用途 |
| EP3160497A4 (en) | 2014-06-27 | 2018-01-17 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Conjugates for immunotherapy |
| WO2016023040A1 (en) | 2014-08-08 | 2016-02-11 | Alexo Therapeutics International | Sirp-alpha variant constructs and uses thereof |
| JP6640834B2 (ja) | 2014-08-11 | 2020-02-05 | デリニア， インコーポレイテッド | 自己免疫疾患の処置のために調節性ｔ細胞を選択的に活性化させる改変ｉｌ−２変異体 |
| ES2751915T5 (es) | 2014-08-15 | 2022-12-23 | Merck Patent Gmbh | Proteínas de fusión de inmunoglobulina con SIRP alfa |
| CN106999583A (zh) | 2014-11-17 | 2017-08-01 | 豪夫迈·罗氏有限公司 | 包含ox40结合激动剂和pd‑1轴结合拮抗剂的组合疗法 |
| MX2017007136A (es) | 2014-12-05 | 2017-12-04 | Immunext Inc | Identificacion de vsig8 como el receptor vista putativo y su uso para producir moduladores vista/vsig8. |
| WO2016112983A1 (en) * | 2015-01-15 | 2016-07-21 | Biontech Ag | Cytokine fusion proteins |
| WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| MA41460A (fr) | 2015-02-03 | 2017-12-12 | Oncomed Pharm Inc | Agents de liaison à la tnfrsf et leurs utilisations |
| US10046047B2 (en) | 2015-02-06 | 2018-08-14 | Heat Biologics, Inc. | Vector co-expressing vaccine and costimulatory molecules |
| WO2016166139A1 (en) | 2015-04-14 | 2016-10-20 | Eberhard Karls Universität Tübingen | Bispecific fusion proteins for enhancing immune responses of lymphocytes against tumor cells |
| DK3298043T3 (da) | 2015-05-18 | 2021-02-15 | Ab Initio Biotherapeutics Inc | SIRP-polypeptidsammensætninger og fremgangsmåder til anvendelse |
| RU2740672C2 (ru) | 2015-08-07 | 2021-01-19 | ЭйЭлЭкс Онколоджи Инк. | Конструкции, имеющие sirp-альфа домен или его вариант |
| SG10201913573UA (en) | 2015-10-01 | 2020-03-30 | Heat Biologics Inc | Compositions and methods for adjoining type i and type ii extracellular domains as heterologous chimeric proteins |
| EP3529276A4 (en) | 2016-10-21 | 2020-06-17 | Arch Oncology, Inc. | CD47 THERAPEUTIC ANTIBODIES |
| IL268198B2 (en) | 2017-02-27 | 2024-10-01 | Shattuck Labs Inc | Tigit- and light-based chimeric proteins |
-
2018
- 2018-02-27 IL IL268198A patent/IL268198B2/en unknown
- 2018-02-27 JP JP2019546144A patent/JP7128195B2/ja not_active Expired - Fee Related
- 2018-02-27 US US16/484,852 patent/US11332509B2/en active Active
- 2018-02-27 AU AU2018223821A patent/AU2018223821B2/en active Active
- 2018-02-27 CN CN202410811167.XA patent/CN118994414A/zh active Pending
- 2018-02-27 BR BR112019017298-0A patent/BR112019017298A2/pt active Search and Examination
- 2018-02-27 US US16/484,850 patent/US20190367579A1/en not_active Abandoned
- 2018-02-27 MY MYPI2019004825A patent/MY207687A/en unknown
- 2018-02-27 CN CN201880009524.3A patent/CN110234345A/zh active Pending
- 2018-02-27 CA CA3054127A patent/CA3054127A1/en active Pending
- 2018-02-27 WO PCT/US2018/020037 patent/WO2018157162A1/en not_active Ceased
- 2018-02-27 KR KR1020197023430A patent/KR102745835B1/ko active Active
- 2018-02-27 EP EP18757341.5A patent/EP3585425A4/en not_active Withdrawn
- 2018-02-27 MX MX2019009812A patent/MX2019009812A/es unknown
- 2018-02-27 JP JP2019546149A patent/JP7260477B2/ja active Active
- 2018-02-27 SG SG11201906465YA patent/SG11201906465YA/en unknown
- 2018-02-27 EP EP18756868.8A patent/EP3585418A4/en not_active Withdrawn
- 2018-02-27 CN CN201880013956.1A patent/CN110381983B/zh active Active
- 2018-02-27 IL IL313003A patent/IL313003A/en unknown
- 2018-02-27 CA CA3054133A patent/CA3054133A1/en active Pending
- 2018-02-27 WO PCT/US2018/020040 patent/WO2018157165A1/en not_active Ceased
-
2019
- 2019-06-28 PH PH12019501533A patent/PH12019501533A1/en unknown
- 2019-08-20 ZA ZA2019/05488A patent/ZA201905488B/en unknown
-
2020
- 2020-04-24 US US16/857,787 patent/US10899817B2/en active Active
- 2020-09-10 US US17/017,108 patent/US10927159B2/en active Active
-
2022
- 2022-04-06 US US17/714,912 patent/US20220227831A1/en not_active Abandoned
- 2022-04-11 US US17/717,740 patent/US12071465B2/en active Active
- 2022-08-18 JP JP2022130749A patent/JP2022159510A/ja active Pending
- 2022-08-18 AU AU2022218575A patent/AU2022218575A1/en not_active Abandoned
-
2023
- 2023-04-06 JP JP2023062366A patent/JP7620045B2/ja active Active
-
2024
- 2024-03-04 US US18/594,400 patent/US20240190939A1/en not_active Abandoned
- 2024-07-17 US US18/775,288 patent/US20240368242A1/en active Pending
-
2025
- 2025-01-09 JP JP2025003769A patent/JP2025061180A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020508329A5 (enExample) | ||
| JP7286543B2 (ja) | Ｃｅａを標的にする多重特異性結合タンパク質 | |
| JP2021533161A (ja) | Ｈｅｒ２、ｎｋｇ２ｄおよびｃｄ１６に結合する多重特異性結合タンパク質ならびに使用方法 | |
| US20160347814A1 (en) | Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases | |
| KR20240167101A (ko) | Nkg2d, cd16 및 넥틴4에 결합하는 단백질 | |
| JP2018529363A5 (enExample) | ||
| BR112020003050A2 (pt) | proteínas de ligação a nkg2d, cd16, e egfr, hla-e, ccr4 ou pd-l1 | |
| JP2020508063A5 (enExample) | ||
| JP2021522835A (ja) | 二機能性結合ポリペプチド | |
| JP2022511286A (ja) | Ｓｉｒｐアルファ系キメラタンパク質を含む併用療法 | |
| JP2020521448A (ja) | Ｎｋｇ２ｄ、ｃｄ１６、およびｒｏｒ１またはｒｏｒ２に結合するタンパク質 | |
| CN110475857B (zh) | 表达抗-可替宁嵌合抗原受体的天然杀伤细胞 | |
| JP2020529410A (ja) | Ｎｋｇ２ｄ、ｃｄ１６及びｆｌｔ３と結合するタンパク質 | |
| WO2016180034A1 (zh) | 抗ctla-4和pd-1的双重可变结构域免疫球蛋白 | |
| CN103965363A (zh) | 与pd-1和vegf高效结合的融合蛋白、其编码序列及用途 | |
| BR112020004458A2 (pt) | Anticorpo ou seu fragmento de ligação ao antígeno eao epítopo ou proteína de fusão, ácido nucleico, composição farmacêutica, e, usos de um anticorpo ou fragmento de ligação ao antígeno ou uma composição farmacêutica para preparar um medicamento para induzir, promover ou aumentar uma resposta imune, para tratar o câncer, para reduzir a carga tumoral e para tratar uma infecção em um sujeito em necessidade | |
| WO2020143720A1 (zh) | 阻断血管内皮细胞生长且活化t细胞的多靶向融合蛋白和包含其的药物组合物 | |
| JP2020508998A (ja) | Ｃｄ１２３、ｎｋｇ２ｄおよびｃｄ１６に結合するタンパク質 | |
| CN104284680A (zh) | 使用对受体的亲和力增加的突变型light分子用于癌症治疗的方法和组合物 | |
| KR20190124247A (ko) | Csf1r-기반 키메라 단백질 | |
| WO2021238904A1 (zh) | Fc-CD80融合蛋白和其缀合物以及它们的用途 | |
| JP2022513421A5 (enExample) | ||
| JP2022512540A (ja) | Ｆｌｔ３ｌ系キメラタンパク質 | |
| JP2022512540A5 (enExample) | ||
| JP2025522459A (ja) | Ｋｒａｓ ｇ１２ｖ突然変異ポリペプチドを標的するｔ細胞受容体及びその用途 |