JP7244428B2 - Ｖｓｉｇ８ベースのキメラタンパク質 - Google Patents

Ｖｓｉｇ８ベースのキメラタンパク質 Download PDF

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JP7244428B2
JP7244428B2 JP2019546141A JP2019546141A JP7244428B2 JP 7244428 B2 JP7244428 B2 JP 7244428B2 JP 2019546141 A JP2019546141 A JP 2019546141A JP 2019546141 A JP2019546141 A JP 2019546141A JP 7244428 B2 JP7244428 B2 JP 7244428B2
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chimeric protein
ox40l
amino acid
cells
seq
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JP2020508066A (ja
JP2020508066A5 (enExample
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シュライバー，テイラー
フロム，ジョージ
シルヴァ，サレシュ デ
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シャタック ラボ，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP2019546141A 2017-02-27 2018-02-27 Ｖｓｉｇ８ベースのキメラタンパク質 Active JP7244428B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023036738A JP2023071979A (ja) 2017-02-27 2023-03-09 Ｖｓｉｇ８ベースのキメラタンパク質
JP2025020276A JP2025065443A (ja) 2017-02-27 2025-02-10 Ｖｓｉｇ８ベースのキメラタンパク質

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762463999P 2017-02-27 2017-02-27
US62/463,999 2017-02-27
PCT/US2018/020038 WO2018157163A1 (en) 2017-02-27 2018-02-27 Vsig8-based chimeric proteins

Related Child Applications (1)

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JP2023036738A Division JP2023071979A (ja) 2017-02-27 2023-03-09 Ｖｓｉｇ８ベースのキメラタンパク質

Publications (3)

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JP2020508066A JP2020508066A (ja) 2020-03-19
JP2020508066A5 JP2020508066A5 (enExample) 2021-04-08
JP7244428B2 true JP7244428B2 (ja) 2023-03-22

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JP2019546141A Active JP7244428B2 (ja) 2017-02-27 2018-02-27 Ｖｓｉｇ８ベースのキメラタンパク質
JP2023036738A Pending JP2023071979A (ja) 2017-02-27 2023-03-09 Ｖｓｉｇ８ベースのキメラタンパク質
JP2025020276A Withdrawn JP2025065443A (ja) 2017-02-27 2025-02-10 Ｖｓｉｇ８ベースのキメラタンパク質

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JP2025020276A Withdrawn JP2025065443A (ja) 2017-02-27 2025-02-10 Ｖｓｉｇ８ベースのキメラタンパク質

Country Status (8)

Country Link
US (4) US11192933B2 (enExample)
EP (2) EP3585410B9 (enExample)
JP (3) JP7244428B2 (enExample)
CN (2) CN118184797A (enExample)
AU (1) AU2018224852B2 (enExample)
CA (1) CA3054130A1 (enExample)
IL (1) IL268170A (enExample)
WO (1) WO2018157163A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113747947A (zh) * 2019-02-28 2021-12-03 沙塔克实验室有限公司 组合疗法
US20220259281A1 (en) * 2019-06-21 2022-08-18 Shattuck Labs, Inc. Chimeric protein expressing t-cells
JP2024527902A (ja) * 2021-07-26 2024-07-26 カイト ファーマ インコーポレイテッド Ｄｎｖｓｉｇ３及びｄｎｖｓｉｇ８受容体並びにその使用方法
WO2024123812A1 (en) 2022-12-05 2024-06-13 Shattuck Labs, Inc. Fusion proteins for the treatment of cardiometabolic diseases

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US20190367581A1 (en) 2019-12-05
AU2018224852B2 (en) 2025-03-06
CN118184797A (zh) 2024-06-14
JP2020508066A (ja) 2020-03-19
US11834488B2 (en) 2023-12-05
JP2025065443A (ja) 2025-04-17
EP4249503A3 (en) 2023-12-20
EP3585410A1 (en) 2020-01-01
US20220119481A1 (en) 2022-04-21
CA3054130A1 (en) 2018-08-30
EP4249503A2 (en) 2023-09-27
EP3585410A4 (en) 2020-12-16
CN110290798A (zh) 2019-09-27
AU2018224852A1 (en) 2019-07-11
EP3585410B1 (en) 2023-06-07
US20200071378A1 (en) 2020-03-05
WO2018157163A1 (en) 2018-08-30
US20240067698A1 (en) 2024-02-29
IL268170A (en) 2019-09-26
JP2023071979A (ja) 2023-05-23
CN110290798B (zh) 2024-04-05
US11192934B2 (en) 2021-12-07
US11192933B2 (en) 2021-12-07
EP3585410B9 (en) 2023-10-04

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