JP2017516458A5 - - Google Patents

Info

Publication number

JP2017516458A5

JP2017516458A5 JP2016558594A JP2016558594A JP2017516458A5 JP 2017516458 A5 JP2017516458 A5 JP 2017516458A5 JP 2016558594 A JP2016558594 A JP 2016558594A JP 2016558594 A JP2016558594 A JP 2016558594A JP 2017516458 A5 JP2017516458 A5 JP 2017516458A5

Authority

JP

Japan

Prior art keywords

hgf

patient

cancer

biomarker

expression

Prior art date

2015-03-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000000090 biomarker Substances 0.000 claims 35
• 239000005557 antagonist Substances 0.000 claims 24
• 206010028980 Neoplasm Diseases 0.000 claims 18
• 201000011510 cancer Diseases 0.000 claims 18
• 238000007901 in situ hybridization Methods 0.000 claims 17
• 238000000034 method Methods 0.000 claims 16
• 108020004999 messenger RNA Proteins 0.000 claims 10
• 238000011282 treatment Methods 0.000 claims 10
• 208000005017 glioblastoma Diseases 0.000 claims 7
• 206010027406 Mesothelioma Diseases 0.000 claims 6
• 208000006265 Renal cell carcinoma Diseases 0.000 claims 6
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 6
• 206010017758 gastric cancer Diseases 0.000 claims 6
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims 6
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 6
• 201000011549 stomach cancer Diseases 0.000 claims 6
• 238000009007 Diagnostic Kit Methods 0.000 claims 5
• 206010039491 Sarcoma Diseases 0.000 claims 5
• 108020004707 nucleic acids Proteins 0.000 claims 5
• 150000007523 nucleic acids Chemical class 0.000 claims 5
• 102000039446 nucleic acids Human genes 0.000 claims 5
• 238000003559 RNA-seq method Methods 0.000 claims 3
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 3
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 3
• 238000010208 microarray analysis Methods 0.000 claims 3
• 235000002020 sage Nutrition 0.000 claims 3
• VMJFTOSOFDEKTM-UHFFFAOYSA-N 1-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]-n-(pyridin-2-ylmethyl)methanesulfonamide Chemical compound C1=NN(C)C=C1C1=CN=C(C=CC=2C(=CC(CS(=O)(=O)NCC=3N=CC=CC=3)=CC=2)C2=O)C2=C1 VMJFTOSOFDEKTM-UHFFFAOYSA-N 0.000 claims 2
• PDMUGYOXRHVNMO-UHFFFAOYSA-N 2-[4-[3-(6-quinolinylmethyl)-5-triazolo[4,5-b]pyrazinyl]-1-pyrazolyl]ethanol Chemical compound C1=NN(CCO)C=C1C1=CN=C(N=NN2CC=3C=C4C=CC=NC4=CC=3)C2=N1 PDMUGYOXRHVNMO-UHFFFAOYSA-N 0.000 claims 2
• LIOLIMKSCNQPLV-UHFFFAOYSA-N 2-fluoro-n-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1C1=NN2C(CC=3C=C4C=CC=NC4=CC=3)=CN=C2N=C1 LIOLIMKSCNQPLV-UHFFFAOYSA-N 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• HEAIZQNMNCHNFD-UHFFFAOYSA-N AMG-208 Chemical compound C=1C=NC2=CC(OC)=CC=C2C=1OCC(N1N=2)=NN=C1C=CC=2C1=CC=CC=C1 HEAIZQNMNCHNFD-UHFFFAOYSA-N 0.000 claims 2
• UQRCJCNVNUFYDX-UHFFFAOYSA-N Golvatinib Chemical compound C1CN(C)CCN1C1CCN(C(=O)NC=2N=CC=C(OC=3C=C(F)C(NC(=O)C4(CC4)C(=O)NC=4C=CC(F)=CC=4)=CC=3)C=2)CC1 UQRCJCNVNUFYDX-UHFFFAOYSA-N 0.000 claims 2
• 101000666856 Homo sapiens Vasoactive intestinal polypeptide receptor 1 Proteins 0.000 claims 2
• UFICVEHDQUKCEA-UHFFFAOYSA-N N-[[3-fluoro-4-[[2-(1-methyl-4-imidazolyl)-7-thieno[3,2-b]pyridinyl]oxy]anilino]-sulfanylidenemethyl]-2-phenylacetamide Chemical compound CN1C=NC(C=2SC3=C(OC=4C(=CC(NC(=S)NC(=O)CC=5C=CC=CC=5)=CC=4)F)C=CN=C3C=2)=C1 UFICVEHDQUKCEA-UHFFFAOYSA-N 0.000 claims 2
• 238000011529 RT qPCR Methods 0.000 claims 2
• 102100038388 Vasoactive intestinal polypeptide receptor 1 Human genes 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 238000001514 detection method Methods 0.000 claims 2
• 238000005516 engineering process Methods 0.000 claims 2
• 229950007540 glesatinib Drugs 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 230000004083 survival effect Effects 0.000 claims 2
• JRWCBEOAFGHNNU-UHFFFAOYSA-N 6-[difluoro-[6-(1-methyl-4-pyrazolyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline Chemical compound C1=NN(C)C=C1C1=NN2C(C(F)(F)C=3C=C4C=CC=NC4=CC=3)=NN=C2C=C1 JRWCBEOAFGHNNU-UHFFFAOYSA-N 0.000 claims 1
• 201000009030 Carcinoma Diseases 0.000 claims 1
• -1 EMD1204831 Chemical compound 0.000 claims 1
• 229960000397 bevacizumab Drugs 0.000 claims 1
• 239000003560 cancer drug Substances 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000003550 marker Substances 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1