JP5389665B2 - ヒト化ｖｅｇｆを発現するトランスジェニックマウス - Google Patents
ヒト化ｖｅｇｆを発現するトランスジェニックマウス Download PDFInfo
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| US87173606P | 2006-12-22 | 2006-12-22 | |
| US60/871,736 | 2006-12-22 | ||
| PCT/US2007/088537 WO2008080052A1 (en) | 2006-12-22 | 2007-12-21 | Transgenic mice expressing humanized vegf |
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| JP2010514421A JP2010514421A (ja) | 2010-05-06 |
| JP2010514421A5 JP2010514421A5 (enExample) | 2011-08-18 |
| JP5389665B2 true JP5389665B2 (ja) | 2014-01-15 |
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| EP (1) | EP2099920B1 (enExample) |
| JP (1) | JP5389665B2 (enExample) |
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| CN105950654B (zh) | 2010-11-27 | 2020-03-20 | 朱坚 | 一种人源化的转基因动物 |
| JP2016507244A (ja) * | 2013-02-27 | 2016-03-10 | ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト（ゲーエムベーハー）Ｈｅｌｍｈｏｌｔｚ Ｚｅｎｔｒｕｍ ＭｕｅｎｃｈｅｎＤｅｕｔｓｃｈｅｓ Ｆｏｒｓｃｈｕｎｇｓｚｅｎｔｒｕｍ ｆｕｅｒ Ｇｅｓｕｎｄｈｅｉｔ ｕｎｄ Ｕｍｗｅｌｔ （ＧｍｂＨ） | Ｃａｓ９ヌクレアーゼによる卵母細胞における遺伝子編集 |
| US20140273031A1 (en) * | 2013-03-15 | 2014-09-18 | The Cleveland Clinic Foundation | In-vitro method for monoclonal antibody production |
| BR112016026245A2 (pt) | 2014-05-30 | 2018-02-20 | Regeneron Pharma | ?roedor, e, métodos para fazer um roedor humanizado, para fazer um camundongo com dpp4 humanizado, para fazer um roedor transgênico humanizado e para determinar a eficácia terapêutica in vivo de um antagonista da dpp4 específica para humanos no roedor? |
| JP2019506897A (ja) * | 2016-01-19 | 2019-03-14 | セルジーン コーポレイション | ヒトのセレブロンを発現するトランスジェニックマウス |
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| US5332671A (en) * | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
| US6130071A (en) * | 1997-02-05 | 2000-10-10 | Helsinki University Licensing, Ltd. | Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof |
| US6479729B1 (en) * | 1998-02-06 | 2002-11-12 | The Johns Hopkins University | Mouse model for ocular neovascularization |
| WO2005042575A2 (en) * | 2003-10-30 | 2005-05-12 | Pharmexa A/S | Method for down-regulation of vegf |
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- 2007-12-21 JP JP2009543253A patent/JP5389665B2/ja not_active Expired - Fee Related
- 2007-12-21 WO PCT/US2007/088537 patent/WO2008080052A1/en not_active Ceased
- 2007-12-21 ES ES07855314.6T patent/ES2497496T3/es active Active
- 2007-12-21 EP EP07855314.6A patent/EP2099920B1/en active Active
Also Published As
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| EP2099920B1 (en) | 2014-06-25 |
| US8110720B2 (en) | 2012-02-07 |
| WO2008080052A1 (en) | 2008-07-03 |
| ES2497496T3 (es) | 2014-09-23 |
| US20100162415A1 (en) | 2010-06-24 |
| EP2099920A1 (en) | 2009-09-16 |
| JP2010514421A (ja) | 2010-05-06 |
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