JP2019505216A5 - - Google Patents
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- Publication number
- JP2019505216A5 JP2019505216A5 JP2018540723A JP2018540723A JP2019505216A5 JP 2019505216 A5 JP2019505216 A5 JP 2019505216A5 JP 2018540723 A JP2018540723 A JP 2018540723A JP 2018540723 A JP2018540723 A JP 2018540723A JP 2019505216 A5 JP2019505216 A5 JP 2019505216A5
- Authority
- JP
- Japan
- Prior art keywords
- rodent
- angptl8
- gene
- human
- endogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662291446P | 2016-02-04 | 2016-02-04 | |
| US62/291,446 | 2016-02-04 | ||
| PCT/US2017/016487 WO2017136712A1 (en) | 2016-02-04 | 2017-02-03 | Non-human animals having an engineered angptl8 gene |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019505216A JP2019505216A (ja) | 2019-02-28 |
| JP2019505216A5 true JP2019505216A5 (enExample) | 2020-03-05 |
| JP6843872B2 JP6843872B2 (ja) | 2021-03-17 |
Family
ID=58044217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018540723A Expired - Fee Related JP6843872B2 (ja) | 2016-02-04 | 2017-02-03 | 操作されたａｎｇｐｔｌ８遺伝子を有する非ヒト動物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10582702B2 (enExample) |
| EP (1) | EP3411392B1 (enExample) |
| JP (1) | JP6843872B2 (enExample) |
| KR (1) | KR102487839B1 (enExample) |
| CN (1) | CN108779159B (enExample) |
| AU (1) | AU2017213627B2 (enExample) |
| CA (1) | CA3012693C (enExample) |
| ES (1) | ES2908669T3 (enExample) |
| IL (1) | IL260620B (enExample) |
| MA (1) | MA43962A (enExample) |
| MX (1) | MX2018009513A (enExample) |
| RU (1) | RU2742354C2 (enExample) |
| SG (1) | SG11201806176PA (enExample) |
| WO (1) | WO2017136712A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3585162B1 (en) | 2017-09-29 | 2023-08-30 | Regeneron Pharmaceuticals, Inc. | Rodents comprising a humanized ttr locus and methods of use |
| HUE067361T2 (hu) | 2018-07-16 | 2024-10-28 | Regeneron Pharma | Ditra betegség rágcsáló modelljei és alkalmazásaik |
| AU2020253532B2 (en) | 2019-04-04 | 2024-06-20 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized coagulation factor 12 locus |
| WO2020247452A1 (en) | 2019-06-04 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| SG11202111256XA (en) | 2019-06-07 | 2021-11-29 | Regeneron Pharma | Non-human animals comprising a humanized albumin locus |
| CN114671943B (zh) * | 2022-04-29 | 2023-05-05 | 四川大学 | 一种鱼类摄食调控蛋白的制备和应用 |
| CN119367545B (zh) * | 2025-01-02 | 2025-04-08 | 山东第一医科大学(山东省医学科学院) | 靶向干预ANGPTL8 mRNA在制备治疗高同型半胱氨酸血症药物中的应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| ES2429034T3 (es) * | 2001-11-16 | 2013-11-12 | Genentech, Inc. | Uso de antagonistas de ANGPTL3 para el tratamiento de enfermedades hepáticas |
| MXPA06014611A (es) * | 2004-06-18 | 2008-03-11 | Banner Health | Evaluacion de un tratamiento para disminuir el riesgo de un desorden cerebral progresivo o para frenar el envejecimiento del cerebro. |
| EP1802193B1 (en) | 2004-10-19 | 2014-04-30 | Regeneron Pharmaceuticals, Inc. | Method for generating a mouse homozygous for a genetic modification |
| US20110097330A1 (en) * | 2005-03-11 | 2011-04-28 | Genentech, Inc. | Novel Gene Disruptions, Compostitions and Methods Relating Thereto |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| US8518392B2 (en) | 2009-08-14 | 2013-08-27 | Regeneron Pharmaceuticals, Inc. | Promoter-regulated differentiation-dependent self-deleting cassette |
| EP3417701B1 (en) | 2009-10-06 | 2021-12-15 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| RU2577978C2 (ru) | 2011-02-15 | 2016-03-20 | Ридженерон Фармасьютикалз, Инк. | Гуманизированные m-csf мыши |
| SG10201510056SA (en) * | 2011-10-28 | 2016-01-28 | Regeneron Pharma | Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules |
| RU2751240C2 (ru) | 2011-10-28 | 2021-07-12 | Регенерон Фармасьютикалс, Инк. | Гуманизированные il-6 и рецептор il-6 |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| NZ746089A (en) | 2012-09-07 | 2020-05-29 | Institute For Res In Biomedicine Irb | Genetically modified non-human animals and methods of use thereof |
| JP6475172B2 (ja) | 2013-02-20 | 2019-02-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ラットの遺伝子組換え |
| SMT202500280T1 (it) | 2013-09-23 | 2025-09-12 | Regeneron Pharma | Animali non umani aventi un gene umanizzato della proteina regolatrice del segnale |
| TR201904342T4 (tr) | 2013-10-15 | 2019-05-21 | Regeneron Pharma | Hümani̇ze il-15 hayvanlar |
| EP3430898A1 (en) | 2013-11-19 | 2019-01-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized a proliferation-inducing ligand gene |
| EP3071024B1 (en) | 2013-11-19 | 2018-09-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| KR102821645B1 (ko) * | 2014-05-19 | 2025-06-19 | 리제너론 파마슈티칼스 인코포레이티드 | 인간 epo를 발현하는 유전자 변형된 비-인간 동물 |
| DK3157956T3 (da) | 2014-06-19 | 2020-04-27 | Regeneron Pharma | Ikke-humane dyr med et humaniseret gen med programmeret celledød 1 |
| WO2016054494A1 (en) * | 2014-10-03 | 2016-04-07 | Ngm Biopharmaceuticals, Inc. | Methods and compositions for treatment of conditions associated with elevated triglycerides |
| ES2969389T3 (es) | 2014-12-05 | 2024-05-17 | Regeneron Pharma | Animales no humanos que tienen un gen del grupo de diferenciación 47 humanizado |
| EP4399969A3 (en) | 2014-12-09 | 2024-10-30 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| CN105671189A (zh) * | 2016-04-03 | 2016-06-15 | 信阳师范学院 | 一种基于黄牛Angptl8基因单核苷酸多态性的分子育种方法 |
-
2017
- 2017-02-03 US US15/424,322 patent/US10582702B2/en active Active
- 2017-02-03 MX MX2018009513A patent/MX2018009513A/es unknown
- 2017-02-03 MA MA043962A patent/MA43962A/fr unknown
- 2017-02-03 SG SG11201806176PA patent/SG11201806176PA/en unknown
- 2017-02-03 KR KR1020187023863A patent/KR102487839B1/ko active Active
- 2017-02-03 AU AU2017213627A patent/AU2017213627B2/en not_active Ceased
- 2017-02-03 RU RU2018130003A patent/RU2742354C2/ru active
- 2017-02-03 CN CN201780015045.8A patent/CN108779159B/zh active Active
- 2017-02-03 WO PCT/US2017/016487 patent/WO2017136712A1/en not_active Ceased
- 2017-02-03 JP JP2018540723A patent/JP6843872B2/ja not_active Expired - Fee Related
- 2017-02-03 ES ES17705276T patent/ES2908669T3/es active Active
- 2017-02-03 CA CA3012693A patent/CA3012693C/en active Active
- 2017-02-03 EP EP17705276.8A patent/EP3411392B1/en active Active
-
2018
- 2018-07-16 IL IL260620A patent/IL260620B/en active IP Right Grant
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