JP2019505216A5 - - Google Patents
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- Publication number
- JP2019505216A5 JP2019505216A5 JP2018540723A JP2018540723A JP2019505216A5 JP 2019505216 A5 JP2019505216 A5 JP 2019505216A5 JP 2018540723 A JP2018540723 A JP 2018540723A JP 2018540723 A JP2018540723 A JP 2018540723A JP 2019505216 A5 JP2019505216 A5 JP 2019505216A5
- Authority
- JP
- Japan
- Prior art keywords
- rodent
- angptl8
- gene
- human
- endogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662291446P | 2016-02-04 | 2016-02-04 | |
| US62/291,446 | 2016-02-04 | ||
| PCT/US2017/016487 WO2017136712A1 (en) | 2016-02-04 | 2017-02-03 | Non-human animals having an engineered angptl8 gene |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019505216A JP2019505216A (ja) | 2019-02-28 |
| JP2019505216A5 true JP2019505216A5 (enExample) | 2020-03-05 |
| JP6843872B2 JP6843872B2 (ja) | 2021-03-17 |
Family
ID=58044217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018540723A Expired - Fee Related JP6843872B2 (ja) | 2016-02-04 | 2017-02-03 | 操作されたａｎｇｐｔｌ８遺伝子を有する非ヒト動物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10582702B2 (enExample) |
| EP (1) | EP3411392B1 (enExample) |
| JP (1) | JP6843872B2 (enExample) |
| KR (1) | KR102487839B1 (enExample) |
| CN (1) | CN108779159B (enExample) |
| AU (1) | AU2017213627B2 (enExample) |
| CA (1) | CA3012693C (enExample) |
| ES (1) | ES2908669T3 (enExample) |
| IL (1) | IL260620B (enExample) |
| MA (1) | MA43962A (enExample) |
| MX (1) | MX2018009513A (enExample) |
| RU (1) | RU2742354C2 (enExample) |
| SG (1) | SG11201806176PA (enExample) |
| WO (1) | WO2017136712A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2962277T3 (es) | 2017-09-29 | 2024-03-18 | Regeneron Pharma | Roedores que comprenden un locus Ttr humanizado y métodos de uso |
| HRP20240999T1 (hr) | 2018-07-16 | 2024-10-25 | Regeneron Pharmaceuticals, Inc. | Glodavački modeli bolesti ditra i njihova upotreba |
| WO2020206139A1 (en) | 2019-04-04 | 2020-10-08 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized coagulation factor 12 locus |
| EP3801011A1 (en) | 2019-06-04 | 2021-04-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| AU2020289581B2 (en) | 2019-06-07 | 2024-11-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized albumin locus |
| CN114671943B (zh) * | 2022-04-29 | 2023-05-05 | 四川大学 | 一种鱼类摄食调控蛋白的制备和应用 |
| CN119367545B (zh) * | 2025-01-02 | 2025-04-08 | 山东第一医科大学(山东省医学科学院) | 靶向干预ANGPTL8 mRNA在制备治疗高同型半胱氨酸血症药物中的应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| EP1451578B1 (en) * | 2001-11-16 | 2013-08-21 | Genentech, Inc. | Use of angptl3 antagonists for the treatment of liver diseases |
| US20050283054A1 (en) | 2004-06-18 | 2005-12-22 | Banner Health | Evaluation of a treatment to decrease the risk of a progressive brain disorder or to slow brain aging |
| AU2005295269B2 (en) | 2004-10-19 | 2010-05-13 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
| JP2008532516A (ja) * | 2005-03-11 | 2008-08-21 | ジェネンテック・インコーポレーテッド | 遺伝子破壊、組成物、およびそれに関連する方法 |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| WO2011020014A1 (en) | 2009-08-14 | 2011-02-17 | Regeneron Pharmaceuticals, Inc. | Promoter-regulated differentiation-dependent self-deleting cassette |
| CA3040377C (en) | 2009-10-06 | 2025-12-30 | Yale University | Genetically modified mice and engraftment comprising the knock-in of a human thrombopoietin (tpo) gene |
| ES3040596T3 (en) | 2011-02-15 | 2025-11-03 | Regeneron Pharma | Humanized m-csf mice and uses thereof |
| RS56330B1 (sr) * | 2011-10-28 | 2017-12-29 | Regeneron Pharma | Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc) |
| MY186903A (en) | 2011-10-28 | 2021-08-26 | Regeneron Pharma | Humanized il-6 and il-6 receptor |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| KR102287541B1 (ko) | 2012-09-07 | 2021-08-10 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
| AU2014218931C1 (en) | 2013-02-20 | 2020-05-14 | Regeneron Pharmaceuticals, Inc. | Genetic modification of rats |
| DK3175706T3 (en) | 2013-09-23 | 2019-03-04 | Regeneron Pharma | Non-human animals with a humanized signal regulatory protein gene |
| SMT201900177T1 (it) | 2013-10-15 | 2019-05-10 | Regeneron Pharma | Animali con il-15 umanizzata |
| CN105792646B (zh) | 2013-11-19 | 2018-03-02 | 瑞泽恩制药公司 | 具有人源化的b细胞活化因子基因的非人动物 |
| SG10201811701YA (en) | 2013-11-19 | 2019-01-30 | Regeneron Pharma | Non-human animals having a humanized a proliferation-inducing ligand gene |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| KR20250096864A (ko) | 2014-05-19 | 2025-06-27 | 리제너론 파마슈티칼스 인코포레이티드 | 인간 epo를 발현하는 유전자 변형된 비-인간 동물 |
| HUE048677T2 (hu) * | 2014-06-19 | 2020-07-28 | Regeneron Pharma | Humanizált programozott sejthalál 1 génnel rendelkezõ nem-humán állatok |
| US10071139B2 (en) * | 2014-10-03 | 2018-09-11 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of conditions associated with elevated triglycerides with an ANGPTL8 polypeptide fragment |
| KR102617691B1 (ko) | 2014-12-05 | 2023-12-27 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 분화 클러스터 47 유전자를 가진 비인간 동물 |
| NZ731954A (en) | 2014-12-09 | 2024-11-29 | Regeneron Pharma | Non-human animals having a humanized cluster of differentiation 274 gene |
| CN105671189A (zh) * | 2016-04-03 | 2016-06-15 | 信阳师范学院 | 一种基于黄牛Angptl8基因单核苷酸多态性的分子育种方法 |
-
2017
- 2017-02-03 CN CN201780015045.8A patent/CN108779159B/zh not_active Expired - Fee Related
- 2017-02-03 SG SG11201806176PA patent/SG11201806176PA/en unknown
- 2017-02-03 KR KR1020187023863A patent/KR102487839B1/ko active Active
- 2017-02-03 MX MX2018009513A patent/MX2018009513A/es unknown
- 2017-02-03 JP JP2018540723A patent/JP6843872B2/ja not_active Expired - Fee Related
- 2017-02-03 US US15/424,322 patent/US10582702B2/en active Active
- 2017-02-03 EP EP17705276.8A patent/EP3411392B1/en active Active
- 2017-02-03 AU AU2017213627A patent/AU2017213627B2/en not_active Ceased
- 2017-02-03 WO PCT/US2017/016487 patent/WO2017136712A1/en not_active Ceased
- 2017-02-03 RU RU2018130003A patent/RU2742354C2/ru active
- 2017-02-03 ES ES17705276T patent/ES2908669T3/es active Active
- 2017-02-03 CA CA3012693A patent/CA3012693C/en active Active
- 2017-02-03 MA MA043962A patent/MA43962A/fr unknown
-
2018
- 2018-07-16 IL IL260620A patent/IL260620B/en active IP Right Grant
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