SG11201806176PA - Non-human animals having an engineered angptl8 gene - Google Patents
Non-human animals having an engineered angptl8 geneInfo
- Publication number
- SG11201806176PA SG11201806176PA SG11201806176PA SG11201806176PA SG11201806176PA SG 11201806176P A SG11201806176P A SG 11201806176PA SG 11201806176P A SG11201806176P A SG 11201806176PA SG 11201806176P A SG11201806176P A SG 11201806176PA SG 11201806176P A SG11201806176P A SG 11201806176PA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- human animals
- new york
- rule
- angptl8
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 108700041144 Angiopoietin-Like Protein 8 Proteins 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 4
- 102100034604 Angiopoietin-like protein 8 Human genes 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 101000924544 Homo sapiens Angiopoietin-like protein 8 Proteins 0.000 abstract 1
- 238000012239 gene modification Methods 0.000 abstract 1
- 230000005017 genetic modification Effects 0.000 abstract 1
- 235000013617 genetically modified food Nutrition 0.000 abstract 1
- 102000050918 human ANGPTL8 Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
- A01K2217/206—Animal model comprising tissue-specific expression system, e.g. tissue specific expression of transgene, of Cre recombinase
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0375—Animal model for cardiovascular diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662291446P | 2016-02-04 | 2016-02-04 | |
| PCT/US2017/016487 WO2017136712A1 (en) | 2016-02-04 | 2017-02-03 | Non-human animals having an engineered angptl8 gene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201806176PA true SG11201806176PA (en) | 2018-08-30 |
Family
ID=58044217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201806176PA SG11201806176PA (en) | 2016-02-04 | 2017-02-03 | Non-human animals having an engineered angptl8 gene |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10582702B2 (enExample) |
| EP (1) | EP3411392B1 (enExample) |
| JP (1) | JP6843872B2 (enExample) |
| KR (1) | KR102487839B1 (enExample) |
| CN (1) | CN108779159B (enExample) |
| AU (1) | AU2017213627B2 (enExample) |
| CA (1) | CA3012693C (enExample) |
| ES (1) | ES2908669T3 (enExample) |
| IL (1) | IL260620B (enExample) |
| MA (1) | MA43962A (enExample) |
| MX (1) | MX2018009513A (enExample) |
| RU (1) | RU2742354C2 (enExample) |
| SG (1) | SG11201806176PA (enExample) |
| WO (1) | WO2017136712A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4276185A3 (en) | 2017-09-29 | 2024-02-21 | Regeneron Pharmaceuticals, Inc. | Rodents comprising a humanized ttr locus and methods of use |
| US11589562B2 (en) | 2018-07-16 | 2023-02-28 | Regeneran Pharmaceuticals, Inc. | Mouse model of DITRA disease and uses thereof |
| IL286905B2 (en) | 2019-04-04 | 2024-06-01 | Regeneron Pharma | Non-human animals containing the human coagulation factor 12 locus |
| KR20220016869A (ko) | 2019-06-04 | 2022-02-10 | 리제너론 파마슈티칼스 인코포레이티드 | 베타-슬립 돌연변이를 갖는 인간화 ttr 좌위를 포함하는 비-인간 동물 및 사용 방법 |
| BR112021022722A2 (pt) | 2019-06-07 | 2022-01-04 | Regeneron Pharma | Animal não humano, célula de animal não humana, genoma de animal não humano, gene de albumina animal não humana humanizada, vetor de alvejamento, método de avaliação da atividade de um reagente, e, método de otimização da atividade de um reagente |
| CN114671943B (zh) * | 2022-04-29 | 2023-05-05 | 四川大学 | 一种鱼类摄食调控蛋白的制备和应用 |
| CN119367545B (zh) * | 2025-01-02 | 2025-04-08 | 山东第一医科大学(山东省医学科学院) | 靶向干预ANGPTL8 mRNA在制备治疗高同型半胱氨酸血症药物中的应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| CN1615440A (zh) * | 2001-11-16 | 2005-05-11 | 杰南技术公司 | 含有血管生成素－样蛋白质3angptl3的组合物及其使用方法 |
| EP1761191A4 (en) | 2004-06-18 | 2008-05-14 | Banner Health | EVALUATION OF A TREATMENT TO REDUCE THE RISK OF EVOLVING BRAVER DISEASE OR TO SLOW BRAIN AGING |
| DK1802193T3 (da) | 2004-10-19 | 2014-06-10 | Regeneron Pharma | Fremgangsmåde til frembringelse af en homozygot mus til genetisk modifikation |
| US20110097330A1 (en) * | 2005-03-11 | 2011-04-28 | Genentech, Inc. | Novel Gene Disruptions, Compostitions and Methods Relating Thereto |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| WO2011020014A1 (en) * | 2009-08-14 | 2011-02-17 | Regeneron Pharmaceuticals, Inc. | Promoter-regulated differentiation-dependent self-deleting cassette |
| ES2908587T3 (es) | 2009-10-06 | 2022-05-03 | Regeneron Pharma | Ratones modificados genéticamente e injerto |
| PT4233537T (pt) | 2011-02-15 | 2025-09-08 | Regeneron Pharma | Ratinhos humanizados para m-csf e utilizações dos mesmos |
| EP2770822B9 (en) * | 2011-10-28 | 2019-12-11 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules |
| BR112014008529A2 (pt) | 2011-10-28 | 2017-04-18 | Regeneron Pharma | il-6 humanizado e receptor de il-6 |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| RU2642319C2 (ru) | 2012-09-07 | 2018-01-24 | Йель Юниверсити | Генетически модифицированные, не принадлежащие к человеческому роду животные и способ их использования |
| EP3561050B1 (en) | 2013-02-20 | 2021-12-08 | Regeneron Pharmaceuticals, Inc. | Genetic modification of rats |
| KR102407354B1 (ko) | 2013-09-23 | 2022-06-10 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 신호-조절 단백질 유전자를 가지는 비-인간 동물 |
| SI3138397T1 (sl) | 2013-10-15 | 2019-04-30 | Regeneron Pharmaceuticals, Inc. | Humanizirane živali IL-15 |
| MX358206B (es) | 2013-11-19 | 2018-08-09 | Regeneron Pharma | Animales no humanos que tienen un gen humanizado de un ligando inductor de la proliferacion. |
| US20150143558A1 (en) | 2013-11-19 | 2015-05-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| MX379268B (es) | 2014-05-19 | 2025-03-11 | Regeneron Pharma | Animales no humanos geneticamente modificados que expresan eritropoyetina de humano. |
| SMT202000184T1 (it) * | 2014-06-19 | 2020-05-08 | Regeneron Pharma | Animali non umani aventi un gene 1 della morte cellulare programmata umanizzato |
| JP6680758B2 (ja) * | 2014-10-03 | 2020-04-15 | エヌジーエム バイオファーマシューティカルズ インコーポレイテッド | 上昇したトリグリセリドと関連する状態の治療のための方法及び組成物 |
| HUE064960T2 (hu) | 2014-12-05 | 2024-04-28 | Regeneron Pharma | Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok |
| AU2015360667B2 (en) | 2014-12-09 | 2021-09-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| CN105671189A (zh) * | 2016-04-03 | 2016-06-15 | 信阳师范学院 | 一种基于黄牛Angptl8基因单核苷酸多态性的分子育种方法 |
-
2017
- 2017-02-03 ES ES17705276T patent/ES2908669T3/es active Active
- 2017-02-03 KR KR1020187023863A patent/KR102487839B1/ko active Active
- 2017-02-03 CN CN201780015045.8A patent/CN108779159B/zh active Active
- 2017-02-03 CA CA3012693A patent/CA3012693C/en active Active
- 2017-02-03 WO PCT/US2017/016487 patent/WO2017136712A1/en not_active Ceased
- 2017-02-03 EP EP17705276.8A patent/EP3411392B1/en active Active
- 2017-02-03 MX MX2018009513A patent/MX2018009513A/es unknown
- 2017-02-03 US US15/424,322 patent/US10582702B2/en active Active
- 2017-02-03 RU RU2018130003A patent/RU2742354C2/ru active
- 2017-02-03 MA MA043962A patent/MA43962A/fr unknown
- 2017-02-03 SG SG11201806176PA patent/SG11201806176PA/en unknown
- 2017-02-03 AU AU2017213627A patent/AU2017213627B2/en not_active Ceased
- 2017-02-03 JP JP2018540723A patent/JP6843872B2/ja not_active Expired - Fee Related
-
2018
- 2018-07-16 IL IL260620A patent/IL260620B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| HK1258506A1 (en) | 2019-11-15 |
| RU2742354C2 (ru) | 2021-02-05 |
| AU2017213627B2 (en) | 2022-05-19 |
| JP2019505216A (ja) | 2019-02-28 |
| IL260620B (en) | 2021-02-28 |
| US10582702B2 (en) | 2020-03-10 |
| EP3411392A1 (en) | 2018-12-12 |
| ES2908669T3 (es) | 2022-05-03 |
| US20170245481A1 (en) | 2017-08-31 |
| RU2018130003A (ru) | 2020-03-04 |
| CN108779159B (zh) | 2022-12-30 |
| EP3411392B1 (en) | 2021-12-29 |
| JP6843872B2 (ja) | 2021-03-17 |
| CN108779159A (zh) | 2018-11-09 |
| MA43962A (fr) | 2018-12-12 |
| KR102487839B1 (ko) | 2023-01-12 |
| KR20180104052A (ko) | 2018-09-19 |
| CA3012693C (en) | 2022-08-23 |
| AU2017213627A1 (en) | 2018-08-09 |
| WO2017136712A1 (en) | 2017-08-10 |
| RU2018130003A3 (enExample) | 2020-06-09 |
| CA3012693A1 (en) | 2017-08-10 |
| MX2018009513A (es) | 2019-01-31 |
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