JP2018512842A5 - - Google Patents
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- JP2018512842A5 JP2018512842A5 JP2017548965A JP2017548965A JP2018512842A5 JP 2018512842 A5 JP2018512842 A5 JP 2018512842A5 JP 2017548965 A JP2017548965 A JP 2017548965A JP 2017548965 A JP2017548965 A JP 2017548965A JP 2018512842 A5 JP2018512842 A5 JP 2018512842A5
- Authority
- JP
- Japan
- Prior art keywords
- mouse
- endogenous
- motor neuron
- locus
- symptom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562133909P | 2015-03-16 | 2015-03-16 | |
| US62/133,909 | 2015-03-16 | ||
| US201562250229P | 2015-11-03 | 2015-11-03 | |
| US62/250,229 | 2015-11-03 | ||
| PCT/US2016/022685 WO2016149398A1 (en) | 2015-03-16 | 2016-03-16 | Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019184476A Division JP2020005660A (ja) | 2015-03-16 | 2019-10-07 | 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512842A JP2018512842A (ja) | 2018-05-24 |
| JP2018512842A5 true JP2018512842A5 (enExample) | 2019-04-25 |
| JP6600694B2 JP6600694B2 (ja) | 2019-10-30 |
Family
ID=55646893
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017548965A Active JP6600694B2 (ja) | 2015-03-16 | 2016-03-16 | 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物 |
| JP2019184476A Pending JP2020005660A (ja) | 2015-03-16 | 2019-10-07 | 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物 |
| JP2020152914A Active JP7193509B2 (ja) | 2015-03-16 | 2020-09-11 | 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物 |
| JP2021215389A Withdrawn JP2022048157A (ja) | 2015-03-16 | 2021-12-29 | 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019184476A Pending JP2020005660A (ja) | 2015-03-16 | 2019-10-07 | 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物 |
| JP2020152914A Active JP7193509B2 (ja) | 2015-03-16 | 2020-09-11 | 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物 |
| JP2021215389A Withdrawn JP2022048157A (ja) | 2015-03-16 | 2021-12-29 | 上位及び下位運動ニューロン機能並びに知覚の減衰を示す非ヒト動物 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10285387B2 (enExample) |
| EP (2) | EP3270688B1 (enExample) |
| JP (4) | JP6600694B2 (enExample) |
| KR (2) | KR102616160B1 (enExample) |
| CN (1) | CN107690279B (enExample) |
| AU (2) | AU2016233250C1 (enExample) |
| BR (1) | BR112017019620A2 (enExample) |
| CA (1) | CA2978096C (enExample) |
| ES (2) | ES2830173T3 (enExample) |
| IL (2) | IL274285B (enExample) |
| MX (2) | MX380521B (enExample) |
| RU (1) | RU2744831C2 (enExample) |
| SG (2) | SG10201912899QA (enExample) |
| WO (1) | WO2016149398A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL294443A (en) * | 2013-08-07 | 2022-09-01 | Regeneron Pharma | Lincrna-deficient non-human animals |
| US10781453B2 (en) * | 2016-09-30 | 2020-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a hexanucleotide repeat expansion in a C9ORF72 locus |
| CN111793607B (zh) * | 2017-07-28 | 2022-05-17 | 杨涛 | 定向诱导hiPSC分化为神经细胞体系中培养神经元细胞的基础培养基 |
| CN107586791B (zh) * | 2017-10-26 | 2018-09-21 | 四川省人民医院 | 一种共济失调动物模型的构建方法以及应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566089B1 (en) | 1996-09-04 | 2003-05-20 | Tularik Inc. | Cell-based drug screens for regulators of gene expression |
| US6358508B1 (en) | 1997-06-11 | 2002-03-19 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor TR9 |
| US6949358B1 (en) | 1997-06-11 | 2005-09-27 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor TR9 |
| WO1999005266A2 (en) | 1997-07-26 | 1999-02-04 | Wisconsin Alumni Research Foundation | Trans-species nuclear transfer |
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| AUPR451401A0 (en) | 2001-04-20 | 2001-05-24 | Monash University | A method of nuclear transfer |
| US20050069540A1 (en) | 2001-12-17 | 2005-03-31 | Jinqi Liu | Treating b-cell mediated diseases by modulating dr6 activity |
| US7612250B2 (en) | 2002-07-29 | 2009-11-03 | Trustees Of Tufts College | Nuclear transfer embryo formation method |
| EP1802193B1 (en) | 2004-10-19 | 2014-04-30 | Regeneron Pharmaceuticals, Inc. | Method for generating a mouse homozygous for a genetic modification |
| CN101117633B (zh) | 2006-08-03 | 2011-07-20 | 上海交通大学附属儿童医院 | 一种细胞核移植方法 |
| CN101616934A (zh) * | 2006-12-22 | 2009-12-30 | 健泰科生物技术公司 | 抑制dr6结合app的dr6抗体及其在治疗神经学病症中的用途 |
| WO2008080045A2 (en) | 2006-12-22 | 2008-07-03 | Genentech, Inc. | Dr6 antibodies inhibiting the binding of dr6 to app, and uses thereof in treating neurological disorders |
| TWI476280B (zh) | 2008-03-07 | 2015-03-11 | Regeneron Pharma | 來自二倍體宿主胚胎注射之ｅｓ－細胞衍生的老鼠 |
| WO2009152463A2 (en) | 2008-06-12 | 2009-12-17 | Genentech, Inc. | Method for screening for compounds that inhibit neurodegeneration |
| KR20110089185A (ko) | 2008-11-25 | 2011-08-04 | 바이오겐 아이덱 엠에이 인코포레이티드 | 신경계 세포의 생존을 촉진하기 위한 ｄｒ６ 및 ｐ７５ 길항제의 용도 |
| TW201034684A (en) * | 2009-02-18 | 2010-10-01 | Genentech Inc | Method for inhibiting neurodegeneration |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| US8518392B2 (en) | 2009-08-14 | 2013-08-27 | Regeneron Pharmaceuticals, Inc. | Promoter-regulated differentiation-dependent self-deleting cassette |
| TR201903376T4 (tr) | 2009-10-29 | 2019-04-22 | Regeneron Pharma | Çok fonksiyonlu alleller. |
| JP6275120B2 (ja) | 2012-04-25 | 2018-02-07 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 大きい標的化ベクターによるヌクレアーゼ媒介標的化 |
| JP6475172B2 (ja) | 2013-02-20 | 2019-02-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ラットの遺伝子組換え |
| EP3456831B1 (en) | 2013-04-16 | 2021-07-14 | Regeneron Pharmaceuticals, Inc. | Targeted modification of rat genome |
| MX388127B (es) | 2013-12-11 | 2025-03-19 | Regeneron Pharma | Metodos y composiciones para la modificacion dirigida de un genoma. |
-
2016
- 2016-03-16 BR BR112017019620-4A patent/BR112017019620A2/pt not_active Application Discontinuation
- 2016-03-16 ES ES16713691T patent/ES2830173T3/es active Active
- 2016-03-16 CA CA2978096A patent/CA2978096C/en active Active
- 2016-03-16 WO PCT/US2016/022685 patent/WO2016149398A1/en not_active Ceased
- 2016-03-16 MX MX2017011918A patent/MX380521B/es unknown
- 2016-03-16 AU AU2016233250A patent/AU2016233250C1/en active Active
- 2016-03-16 CN CN201680016100.0A patent/CN107690279B/zh active Active
- 2016-03-16 SG SG10201912899QA patent/SG10201912899QA/en unknown
- 2016-03-16 JP JP2017548965A patent/JP6600694B2/ja active Active
- 2016-03-16 RU RU2017135557A patent/RU2744831C2/ru active
- 2016-03-16 US US15/072,286 patent/US10285387B2/en active Active
- 2016-03-16 EP EP16713691.0A patent/EP3270688B1/en active Active
- 2016-03-16 IL IL274285A patent/IL274285B/en unknown
- 2016-03-16 KR KR1020227024994A patent/KR102616160B1/ko active Active
- 2016-03-16 ES ES20159001T patent/ES2955841T3/es active Active
- 2016-03-16 KR KR1020177025830A patent/KR102424119B1/ko active Active
- 2016-03-16 SG SG11201706809WA patent/SG11201706809WA/en unknown
- 2016-03-16 EP EP20159001.5A patent/EP3685662B9/en active Active
-
2017
- 2017-09-05 IL IL254333A patent/IL254333B/en active IP Right Grant
- 2017-09-15 MX MX2021002852A patent/MX2021002852A/es unknown
-
2019
- 2019-03-07 US US16/295,543 patent/US20190261610A1/en not_active Abandoned
- 2019-10-07 JP JP2019184476A patent/JP2020005660A/ja active Pending
-
2020
- 2020-09-11 JP JP2020152914A patent/JP7193509B2/ja active Active
-
2021
- 2021-07-07 US US17/368,933 patent/US20210392865A1/en not_active Abandoned
- 2021-12-29 JP JP2021215389A patent/JP2022048157A/ja not_active Withdrawn
-
2022
- 2022-02-07 AU AU2022200784A patent/AU2022200784B2/en active Active
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