SG10201912899QA - Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception - Google Patents

Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception

Info

Publication number
SG10201912899QA
SG10201912899QA SG10201912899QA SG10201912899QA SG10201912899QA SG 10201912899Q A SG10201912899Q A SG 10201912899QA SG 10201912899Q A SG10201912899Q A SG 10201912899QA SG 10201912899Q A SG10201912899Q A SG 10201912899QA SG 10201912899Q A SG10201912899Q A SG 10201912899QA
Authority
SG
Singapore
Prior art keywords
human animal
motor neuron
lower motor
sensory perception
neuron function
Prior art date
Application number
SG10201912899QA
Inventor
Burcin Ikiz
Michael LaCroix-Fralish
Susan D Croll
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG10201912899QA publication Critical patent/SG10201912899QA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A01K2217/077—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out heterozygous knock out animals displaying phenotype
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
SG10201912899QA 2015-03-16 2016-03-16 Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception SG10201912899QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562133909P 2015-03-16 2015-03-16
US201562250229P 2015-11-03 2015-11-03

Publications (1)

Publication Number Publication Date
SG10201912899QA true SG10201912899QA (en) 2020-02-27

Family

ID=55646893

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201912899QA SG10201912899QA (en) 2015-03-16 2016-03-16 Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception
SG11201706809WA SG11201706809WA (en) 2015-03-16 2016-03-16 Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201706809WA SG11201706809WA (en) 2015-03-16 2016-03-16 Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception

Country Status (15)

Country Link
US (3) US10285387B2 (en)
EP (2) EP3270688B1 (en)
JP (4) JP6600694B2 (en)
KR (2) KR102424119B1 (en)
CN (1) CN107690279B (en)
AU (2) AU2016233250C1 (en)
BR (1) BR112017019620A2 (en)
CA (1) CA2978096C (en)
ES (2) ES2955841T3 (en)
HK (1) HK1249360A1 (en)
IL (2) IL274285B (en)
MX (2) MX2017011918A (en)
RU (1) RU2744831C2 (en)
SG (2) SG10201912899QA (en)
WO (1) WO2016149398A1 (en)

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JP6998656B2 (en) 2013-08-07 2022-02-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド lincRNA deletion non-human animal
EP3518667A1 (en) * 2016-09-30 2019-08-07 Regeneron Pharmaceuticals, Inc. Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locus
CN111849899B (en) * 2017-07-28 2022-06-14 杨涛 Induction medium for directionally inducing differentiation of hipscs into neural cell system
CN107586791B (en) * 2017-10-26 2018-09-21 四川省人民医院 A kind of construction method of incoordination animal model and application

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US6358508B1 (en) 1997-06-11 2002-03-19 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor TR9
WO1999005266A2 (en) 1997-07-26 1999-02-04 Wisconsin Alumni Research Foundation Trans-species nuclear transfer
US20050144655A1 (en) 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
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AUPR451401A0 (en) 2001-04-20 2001-05-24 Monash University A method of nuclear transfer
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US7612250B2 (en) 2002-07-29 2009-11-03 Trustees Of Tufts College Nuclear transfer embryo formation method
PL1802193T3 (en) 2004-10-19 2014-09-30 Regeneron Pharma Method for generating a mouse homozygous for a genetic modification
CN101117633B (en) 2006-08-03 2011-07-20 上海交通大学附属儿童医院 Nucleus transplantation method
ZA200904323B (en) * 2006-12-22 2010-08-25 Genentech Inc DR6 antibodies inhibiting the binding of DR6 to APP, and uses thereof in treating neurological disorders
AU2007336770A1 (en) 2006-12-22 2008-07-03 Genentech, Inc. DR6 antibodies inhibiting the binding of DR6 to APP, and uses thereof in treating neurological disorders
ES2665068T3 (en) 2008-03-07 2018-04-24 Regeneron Pharmaceuticals, Inc. Mice derived from ES cells from injection of a diploid host embryo
EP2294413A4 (en) * 2008-06-12 2012-04-25 Genentech Inc Method for screening for compounds that inhibit neurodegeneration
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Also Published As

Publication number Publication date
CA2978096C (en) 2022-06-28
BR112017019620A2 (en) 2018-05-15
JP2020005660A (en) 2020-01-16
AU2016233250B2 (en) 2022-03-03
JP7193509B2 (en) 2022-12-20
CA2978096A1 (en) 2016-09-22
US20190261610A1 (en) 2019-08-29
US10285387B2 (en) 2019-05-14
EP3270688A1 (en) 2018-01-24
JP2020198892A (en) 2020-12-17
US20210392865A1 (en) 2021-12-23
ES2830173T3 (en) 2021-06-03
CN107690279B (en) 2021-07-02
EP3685662B1 (en) 2023-06-07
JP2022048157A (en) 2022-03-25
HK1249360A1 (en) 2018-11-02
JP2018512842A (en) 2018-05-24
CN107690279A (en) 2018-02-13
KR102616160B1 (en) 2023-12-22
RU2744831C2 (en) 2021-03-16
IL254333A0 (en) 2017-11-30
IL274285A (en) 2020-06-30
IL274285B (en) 2022-07-01
AU2022200784A1 (en) 2022-02-24
ES2955841T3 (en) 2023-12-07
MX2021002852A (en) 2021-05-28
RU2017135557A3 (en) 2019-07-29
NZ734906A (en) 2022-02-25
RU2017135557A (en) 2019-04-17
AU2022200784B2 (en) 2024-02-15
AU2016233250A1 (en) 2017-09-14
EP3685662C0 (en) 2023-06-07
KR102424119B1 (en) 2022-07-25
JP6600694B2 (en) 2019-10-30
EP3685662A1 (en) 2020-07-29
EP3270688B1 (en) 2020-08-12
MX2017011918A (en) 2018-05-22
KR20220108828A (en) 2022-08-03
KR20170127459A (en) 2017-11-21
WO2016149398A1 (en) 2016-09-22
SG11201706809WA (en) 2017-09-28
AU2016233250C1 (en) 2022-08-18
IL254333B (en) 2020-05-31
US20160270377A1 (en) 2016-09-22
EP3685662B9 (en) 2023-10-04

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