JP2018533963A5 - - Google Patents
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- Publication number
- JP2018533963A5 JP2018533963A5 JP2018526188A JP2018526188A JP2018533963A5 JP 2018533963 A5 JP2018533963 A5 JP 2018533963A5 JP 2018526188 A JP2018526188 A JP 2018526188A JP 2018526188 A JP2018526188 A JP 2018526188A JP 2018533963 A5 JP2018533963 A5 JP 2018533963A5
- Authority
- JP
- Japan
- Prior art keywords
- lag
- rodent
- polypeptide
- humanized
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562258181P | 2015-11-20 | 2015-11-20 | |
| US62/258,181 | 2015-11-20 | ||
| US201662370430P | 2016-08-03 | 2016-08-03 | |
| US62/370,430 | 2016-08-03 | ||
| PCT/US2016/062733 WO2017087780A1 (en) | 2015-11-20 | 2016-11-18 | Non-human animals having a humanized lymphocyte-activation gene 3 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018533963A JP2018533963A (ja) | 2018-11-22 |
| JP2018533963A5 true JP2018533963A5 (enExample) | 2019-12-12 |
| JP6997708B2 JP6997708B2 (ja) | 2022-02-04 |
Family
ID=57543170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526188A Active JP6997708B2 (ja) | 2015-11-20 | 2016-11-18 | ヒト化されたｌｙｍｐｈｏｃｙｔｅ－ａｃｔｉｖａｔｉｏｎ ｇｅｎｅ ３遺伝子を有する非ヒト動物 |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US10306874B2 (enExample) |
| EP (1) | EP3376857B1 (enExample) |
| JP (1) | JP6997708B2 (enExample) |
| KR (1) | KR102454546B1 (enExample) |
| CN (1) | CN108366548B (enExample) |
| AU (1) | AU2016358101B2 (enExample) |
| BR (1) | BR112018010158A2 (enExample) |
| CA (1) | CA3003786C (enExample) |
| CY (1) | CY1124171T1 (enExample) |
| DK (1) | DK3376857T3 (enExample) |
| ES (1) | ES2872799T3 (enExample) |
| HR (1) | HRP20210824T1 (enExample) |
| HU (1) | HUE054612T2 (enExample) |
| IL (1) | IL258841B (enExample) |
| LT (1) | LT3376857T (enExample) |
| MX (1) | MX2018005389A (enExample) |
| NZ (1) | NZ742447A (enExample) |
| PL (1) | PL3376857T3 (enExample) |
| PT (1) | PT3376857T (enExample) |
| RS (1) | RS61866B1 (enExample) |
| RU (1) | RU2745403C2 (enExample) |
| SG (1) | SG11201803409UA (enExample) |
| SI (1) | SI3376857T1 (enExample) |
| SM (1) | SMT202100299T1 (enExample) |
| WO (1) | WO2017087780A1 (enExample) |
| ZA (1) | ZA201802717B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2841353T3 (es) | 2014-12-09 | 2021-07-08 | Regeneron Pharma | Animales no humanos que tienen un gen del grupo de diferenciación 274 humanizado |
| CN108366548B (zh) | 2015-11-20 | 2021-10-08 | 瑞泽恩制药公司 | 具有人源化淋巴细胞活化基因3的非人动物 |
| CN109068621B (zh) | 2016-02-29 | 2021-07-20 | 再生元制药公司 | 具有人源化的tmprss基因的啮齿类动物 |
| US10912287B2 (en) | 2016-06-28 | 2021-02-09 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd | Genetically modified mice expressing humanized PD-1 |
| CN107815468B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| WO2018086583A1 (en) * | 2016-11-11 | 2018-05-17 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animal with human or chimeric lag-3 |
| CN108070613B (zh) | 2016-11-11 | 2020-03-13 | 百奥赛图江苏基因生物技术有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| WO2019006034A1 (en) * | 2017-06-27 | 2019-01-03 | Regeneron Pharmaceuticals, Inc. | NON-HUMAN ANIMALS COMPRISING A HUMANIZED ASGR1 LOCUS |
| CN111182790A (zh) | 2017-07-31 | 2020-05-19 | 瑞泽恩制药公司 | Crispr报告体非人类动物及其用途 |
| KR102712142B1 (ko) | 2017-07-31 | 2024-10-07 | 리제너론 파마슈티칼스 인코포레이티드 | Cas-형질전환 마우스 배아 줄기 세포 및 마우스 및 이것의 용도 |
| WO2019067875A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE |
| WO2019072241A1 (en) * | 2017-10-13 | 2019-04-18 | Beijing Biocytogen Co., Ltd | NON-HUMAN ANIMAL GENETICALLY MODIFIED WITH PD-1 HUMAN OR CHIMERIC |
| CN109666701B (zh) * | 2017-10-13 | 2021-08-24 | 百奥赛图(北京)医药科技股份有限公司 | 一种pd-1基因修饰人源化动物模型的构建方法及其应用 |
| JP7361031B2 (ja) * | 2017-11-30 | 2023-10-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｔｒｋｂ遺伝子座を含む非ヒト動物 |
| EP3592140A1 (en) | 2018-03-19 | 2020-01-15 | Regeneron Pharmaceuticals, Inc. | Transcription modulation in animals using crispr/cas systems |
| IL277355B2 (en) | 2018-03-26 | 2025-01-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| CA3098040A1 (en) | 2018-07-16 | 2020-01-23 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of ditra disease and uses thereof |
| US12653168B2 (en) | 2018-09-13 | 2026-06-16 | Regeneron Pharmaceuticals, Inc. | Complement factor H gene knockout rat as a model of C3 glomerulopathy |
| WO2020125763A1 (en) | 2018-12-20 | 2020-06-25 | Biocytogen Jiangsu Co., Ltd. | Genetically modified non-human animal with human or chimeric lag3 |
| CN109929875B (zh) * | 2019-03-12 | 2021-02-19 | 江苏集萃药康生物科技股份有限公司 | 一种lag3基因人源化动物模型的构建方法及其应用 |
| JP7506686B2 (ja) | 2019-04-04 | 2024-06-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化凝固因子１２遺伝子座を含む非ヒト動物 |
| WO2020247452A1 (en) | 2019-06-04 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
| CN113939595A (zh) | 2019-06-07 | 2022-01-14 | 瑞泽恩制药公司 | 包括人源化白蛋白基因座的非人动物 |
| WO2021154791A1 (en) | 2020-01-28 | 2021-08-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized pnpla3 locus and methods of use |
| KR20230004472A (ko) * | 2020-04-21 | 2023-01-06 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 cxcl13 유전자를 갖는 비인간 동물 |
| AU2022408167A1 (en) | 2021-12-08 | 2024-06-06 | Regeneron Pharmaceuticals, Inc. | Mutant myocilin disease model and uses thereof |
| WO2025163140A1 (en) * | 2024-02-02 | 2025-08-07 | Vacara Ab | Physiologic humanized mice for studies of mhc class ii function |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3700859B2 (ja) * | 1994-05-06 | 2005-09-28 | アンスティテュ ギュスタブ ルシ | Ｌａｇ−３タンパク質の可溶性ポリペプチドフラクション；製造方法、治療用製剤、抗イディオタイプ抗体 |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20060240024A1 (en) * | 2003-02-28 | 2006-10-26 | The Johns Hopkins University | T cell regulation |
| EP1802193B1 (en) | 2004-10-19 | 2014-04-30 | Regeneron Pharmaceuticals, Inc. | Method for generating a mouse homozygous for a genetic modification |
| AR072999A1 (es) * | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| WO2011020014A1 (en) | 2009-08-14 | 2011-02-17 | Regeneron Pharmaceuticals, Inc. | Promoter-regulated differentiation-dependent self-deleting cassette |
| EP4502152A3 (en) | 2009-10-06 | 2025-04-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| US20130061340A1 (en) * | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc. | Identification and Enrichment of Cell Subpopulations |
| PT4233537T (pt) | 2011-02-15 | 2025-09-08 | Regeneron Pharma | Ratinhos humanizados para m-csf e utilizações dos mesmos |
| RS61455B1 (sr) * | 2011-10-28 | 2021-03-31 | Regeneron Pharma | Genetski modifikovani miševi t ćelijskog receptora |
| KR102295746B1 (ko) | 2011-10-28 | 2021-09-01 | 리제너론 파아마슈티컬스, 인크. | 유전자 변형된 주요 조직적합성 복합체 마우스 |
| RS63220B1 (sr) | 2011-10-28 | 2022-06-30 | Regeneron Pharma | Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc) |
| SI2818478T1 (sl) | 2011-10-28 | 2017-07-31 | Regeneron Pharmaceuticals, Inc. | Humanizirani il-6 in receptor il-6 |
| AR091649A1 (es) * | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| KR102241962B1 (ko) | 2012-09-07 | 2021-04-20 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
| JP6415437B2 (ja) * | 2012-09-17 | 2018-10-31 | ガレクティン・セラピューティクス・インコーポレイテッドＧａｌｅｃｔｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 癌の処置における特異的免疫療法を向上する方法 |
| DK4389764T3 (da) | 2012-11-05 | 2026-04-13 | Regeneron Pharma | Genetisk modificerede gnavere og fremgangsmåder til anvendelse heraf |
| US9848587B2 (en) | 2013-02-20 | 2017-12-26 | Regeneron Pharmaceuticals, Inc. | Humanized T cell co-receptor mice |
| US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
| SI2958937T1 (sl) | 2013-02-22 | 2018-12-31 | Regeneron Pharmaceuticals, Inc. | Miš, ki izraža humanizirani poglavitni histokompatibilnostni kompleks |
| DK3456831T3 (da) | 2013-04-16 | 2021-09-06 | Regeneron Pharma | Målrettet modifikation af rottegenom |
| HRP20231121T1 (hr) | 2013-09-23 | 2023-12-22 | Regeneron Pharmaceuticals, Inc. | Životinje koje nisu ljudi, koje imaju gen za humanizirani protein koji regulira signale |
| MY183188A (en) | 2013-11-19 | 2021-02-18 | Regeneron Pharma | Non-human animals having a humanized b-cell activating factor gene |
| RS60398B1 (sr) | 2014-04-08 | 2020-07-31 | Regeneron Pharma | Ne-humane životinje sa humanizovanim fc-gama receptorima |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| EP3482629B1 (en) | 2014-05-19 | 2020-11-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals expressing human epo |
| WO2015196051A1 (en) * | 2014-06-19 | 2015-12-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized programmed cell death 1 gene |
| BR112017010793A2 (pt) | 2014-11-24 | 2017-12-26 | Regeneron Pharma | animal não humano geneticamente modificado, camundongo, métodos para produzir um animal não humano geneticamente modificado e de triagem de candidatos a fármaco direcionados a um antígeno de interesse, e, modelo de camundongo. |
| BR112017010490A2 (pt) | 2014-12-05 | 2018-04-03 | Regeneron Pharma | roedor, polipeptídeo cd47, célula ou tecido de roedor isolado, célula-tronco emprionária de roedor, embrião de roedor, e, métodos de produzir um roedor, de fornecimento de um roedor, de enxerto de células humanas em um roedor, de avaliação de eficácia terapêutica de uma droga direcionada a células humanas e de avaliar as propriedades farmacocinéticas, de avaliar a toxicidade específica e inespecífica de uma droga direcionada ao cd47 humano. |
| ES2841353T3 (es) | 2014-12-09 | 2021-07-08 | Regeneron Pharma | Animales no humanos que tienen un gen del grupo de diferenciación 274 humanizado |
| MX2017012829A (es) | 2015-04-06 | 2018-02-23 | Regeneron Pharma | Respuestas inmunitarias mediadas por células t humanizadas en animales no humanos. |
| CN108366548B (zh) | 2015-11-20 | 2021-10-08 | 瑞泽恩制药公司 | 具有人源化淋巴细胞活化基因3的非人动物 |
-
2016
- 2016-11-18 CN CN201680067496.1A patent/CN108366548B/zh active Active
- 2016-11-18 DK DK16810152.5T patent/DK3376857T3/da active
- 2016-11-18 EP EP16810152.5A patent/EP3376857B1/en active Active
- 2016-11-18 BR BR112018010158A patent/BR112018010158A2/pt not_active Application Discontinuation
- 2016-11-18 PL PL16810152T patent/PL3376857T3/pl unknown
- 2016-11-18 RS RS20210623A patent/RS61866B1/sr unknown
- 2016-11-18 HU HUE16810152A patent/HUE054612T2/hu unknown
- 2016-11-18 US US15/355,392 patent/US10306874B2/en active Active
- 2016-11-18 ES ES16810152T patent/ES2872799T3/es active Active
- 2016-11-18 PT PT168101525T patent/PT3376857T/pt unknown
- 2016-11-18 HR HRP20210824TT patent/HRP20210824T1/hr unknown
- 2016-11-18 SG SG11201803409UA patent/SG11201803409UA/en unknown
- 2016-11-18 RU RU2018117944A patent/RU2745403C2/ru active
- 2016-11-18 JP JP2018526188A patent/JP6997708B2/ja active Active
- 2016-11-18 SM SM20210299T patent/SMT202100299T1/it unknown
- 2016-11-18 LT LTEP16810152.5T patent/LT3376857T/lt unknown
- 2016-11-18 MX MX2018005389A patent/MX2018005389A/es unknown
- 2016-11-18 SI SI201631205T patent/SI3376857T1/sl unknown
- 2016-11-18 KR KR1020187016719A patent/KR102454546B1/ko active Active
- 2016-11-18 AU AU2016358101A patent/AU2016358101B2/en active Active
- 2016-11-18 NZ NZ742447A patent/NZ742447A/en not_active IP Right Cessation
- 2016-11-18 WO PCT/US2016/062733 patent/WO2017087780A1/en not_active Ceased
- 2016-11-18 CA CA3003786A patent/CA3003786C/en active Active
-
2018
- 2018-04-22 IL IL258841A patent/IL258841B/en active IP Right Grant
- 2018-04-24 ZA ZA2018/02717A patent/ZA201802717B/en unknown
-
2019
- 2019-04-18 US US16/387,664 patent/US11102961B2/en active Active
-
2021
- 2021-05-21 CY CY20211100443T patent/CY1124171T1/el unknown
- 2021-07-29 US US17/388,111 patent/US12096754B2/en active Active
-
2024
- 2024-08-13 US US18/802,201 patent/US20240397919A1/en active Pending
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