RU2749715C2 - Грызуны, характеризующиеся гуманизированным геном tmprss - Google Patents

Грызуны, характеризующиеся гуманизированным геном tmprss Download PDF

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RU2749715C2
RU2749715C2 RU2018131152A RU2018131152A RU2749715C2 RU 2749715 C2 RU2749715 C2 RU 2749715C2 RU 2018131152 A RU2018131152 A RU 2018131152A RU 2018131152 A RU2018131152 A RU 2018131152A RU 2749715 C2 RU2749715 C2 RU 2749715C2
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gene
rodent
tmprss
humanized
human
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RU2018131152A3 (enExample
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НГАМБО Лиса ПУРСЕЛЛ
Александер О. МУДЖИКА
Яцзюнь ТАН
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Регенерон Фармасьютикалз, Инк.
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RU2018131152A 2016-02-29 2017-02-27 Грызуны, характеризующиеся гуманизированным геном tmprss RU2749715C2 (ru)

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US201662301023P 2016-02-29 2016-02-29
US62/301,023 2016-02-29
PCT/US2017/019574 WO2017151453A1 (en) 2016-02-29 2017-02-27 Rodents having a humanized tmprss gene

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RU2749715C2 true RU2749715C2 (ru) 2021-06-16

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KR (2) KR102775366B1 (enExample)
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CA (1) CA3014645C (enExample)
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Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2749715C2 (ru) 2016-02-29 2021-06-16 Регенерон Фармасьютикалз, Инк. Грызуны, характеризующиеся гуманизированным геном tmprss
KR102544051B1 (ko) * 2017-09-29 2023-06-16 리제너론 파마슈티칼스 인코포레이티드 인간화된 ttr 유전자좌를 포함하는 비인간 동물 및 사용 방법
CA3089377A1 (en) 2018-01-26 2019-08-01 Regeneron Pharmaceuticals, Inc. Anti-tmprss2 antibodies and antigen-binding fragments
SMT202400300T1 (it) 2018-07-16 2024-09-16 Regeneron Pharma Modelli di roditori della sindrome ditra e loro utilizzo
AU2020209184A1 (en) 2019-01-17 2021-07-08 Regeneron Pharmaceuticals, Inc. A rodent model of mood disorders
KR20220140503A (ko) 2020-02-10 2022-10-18 리제너론 파마슈티칼스 인코포레이티드 항-tmprss2 항체 및 항원 결합 단편
CN115161326B (zh) * 2021-06-21 2024-09-24 百奥赛图(北京)医药科技股份有限公司 Sost基因人源化非人动物及其构建方法和应用
US20250049006A1 (en) 2021-12-20 2025-02-13 C/O Regeneron Pharmaceuticals, Inc. Non-human animals comprising humanized ace2 and tmprss loci

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026255A1 (en) * 2002-06-25 2005-02-03 Morser John Michael Corin, a serine protease
US20060101531A1 (en) * 2004-08-19 2006-05-11 Fred Hutchinson Cancer Research Center Animal models of cancer development and metastasis
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002065266A (ja) * 2000-08-28 2002-03-05 Teijin Ltd 気道特異的トリプシン様酵素およびその利用法
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
WO2003053136A2 (en) * 2001-12-20 2003-07-03 The Regents Of The University Of California Triple transgenic mouse model of alzheimer's disease
JP2006507813A (ja) * 2002-10-04 2006-03-09 シエーリング アクチエンゲゼルシャフト 置換体活性化配列を有する修飾されたヘプシン分子及びその使用
MXPA05013321A (es) * 2003-06-11 2006-03-09 Schering Ag Nuevas moleculas modificadas de corina que tienen secuencias de activacion sustitutiva y sus usos.
AU2005295269B2 (en) 2004-10-19 2010-05-13 Regeneron Pharmaceuticals, Inc. Method for generating an animal homozygous for a genetic modification
PL2019837T3 (pl) * 2006-05-23 2011-09-30 Irm Llc Związki i kompozycje jako inhibitory proteazy aktywującej kanały
GB0821624D0 (en) * 2008-11-26 2008-12-31 Eisai London Res Lab Ltd Assay
AU2010203353B2 (en) * 2009-01-12 2016-06-16 Cytomx Therapeutics, Inc Modified antibody compositions, methods of making and using thereof
JP5874881B2 (ja) 2009-10-06 2016-03-02 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 遺伝子改変されたマウスおよび移植方法
EP2675271B1 (en) * 2011-02-15 2018-06-13 Regeneron Pharmaceuticals, Inc. Humanized m-csf mice
PL2663575T3 (pl) 2011-10-28 2015-03-31 Regeneron Pharma Humanizowane IL-6 i receptor IL-6
HRP20220616T1 (hr) 2011-10-28 2022-06-24 Regeneron Pharmaceuticals, Inc. Genetski modificirani miš koji eksprimira kimerne molekule glavnog kompleksa histokompatibilnosti (mhc) ii
PT2770821T (pt) 2011-10-28 2017-12-18 Regeneron Pharma Ratinhos de complexo principal de histocompatibilidade principal modificados geneticamente
US9498529B2 (en) * 2012-04-16 2016-11-22 Regeneron Pharmaceuticals, Inc. Methods for treating or preventing influenza virus infection by administering a serine protease inhibitor
US8962913B2 (en) 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
AU2013278075B2 (en) * 2012-06-22 2018-05-17 Cytomx Therapeutics, Inc. Anti-jagged 1/Jagged 2 cross-reactive antibodies, activatable anti-Jagged antibodies and methods of use thereof
KR102340059B1 (ko) 2012-09-07 2021-12-17 예일 유니버시티 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
US9901082B2 (en) 2012-11-05 2018-02-27 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals and methods of use thereof
SG10201706741VA (en) 2013-02-20 2017-10-30 Regeneron Pharma Genetic modification of rats
KR102369454B1 (ko) 2013-02-20 2022-03-04 리제너론 파아마슈티컬스, 인크. 사람화된 t-세포 보조-수용체를 발현하는 마우스
CN110192541B (zh) 2013-02-22 2022-02-18 瑞泽恩制药公司 表达人源化主要组织相容性复合物的小鼠
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
BR112015026197B1 (pt) 2013-04-16 2022-12-06 Regeneron Pharmaceuticals, Inc Método para modificação marcada de um lócus genômico de interesse em uma célula de rato pluripotente
CN116063479A (zh) 2013-06-04 2023-05-05 西托姆克斯治疗公司 用于缀合可活化抗体的组合物和方法
SG11201601184UA (en) 2013-09-23 2016-03-30 Regeneron Pharma Non-human animals having a humanized signal-regulatory protein gene
US9155290B2 (en) 2013-10-15 2015-10-13 Regeneron Pharmaceuticals, Inc. Humanized IL-15 animals
WO2015077071A1 (en) 2013-11-19 2015-05-28 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized b-cell activating factor gene
CN105792647B (zh) 2013-11-19 2018-10-02 瑞泽恩制药公司 具有人源化的增殖诱导配体基因的非人动物
CN106163273B (zh) 2014-04-08 2020-07-24 瑞泽恩制药公司 具有人源化FC-γ受体的非人动物
NO2785538T3 (enExample) 2014-05-07 2018-08-04
KR102821645B1 (ko) 2014-05-19 2025-06-19 리제너론 파마슈티칼스 인코포레이티드 인간 epo를 발현하는 유전자 변형된 비-인간 동물
US10390522B2 (en) 2014-06-19 2019-08-27 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized programmed cell death 1 gene
MX2017006802A (es) 2014-11-24 2018-01-30 Regeneron Pharma Animales no humanos que expresan el complejo cd3 humanizado.
TR201903891T4 (tr) 2014-12-05 2019-04-22 Regeneron Pharma Bir insanlaştırılmış farklılaşma kümesi 47 genine sahip olan insan dışı hayvanlar.
HRP20202034T1 (hr) 2014-12-09 2021-02-19 Regeneron Pharmaceuticals, Inc. Neljudske životinje s genom za humanizirani diferencijacijski biljeg cd274
DK3280257T3 (da) 2015-04-06 2023-09-04 Regeneron Pharma Humaniseret T-celle-formidlet immunrespons i ikke-humane dyr
JP6997708B2 (ja) 2015-11-20 2022-02-04 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒト化されたlymphocyte-activation gene 3遺伝子を有する非ヒト動物
RU2749715C2 (ru) * 2016-02-29 2021-06-16 Регенерон Фармасьютикалз, Инк. Грызуны, характеризующиеся гуманизированным геном tmprss
KR101693243B1 (ko) 2016-06-15 2017-01-05 재단법인 한국파스퇴르연구소 인플루엔자 바이러스의 복제에 관여하는 신규 인간 유전자 및 이의 용도

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026255A1 (en) * 2002-06-25 2005-02-03 Morser John Michael Corin, a serine protease
US20060101531A1 (en) * 2004-08-19 2006-05-11 Fred Hutchinson Cancer Research Center Animal models of cancer development and metastasis
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
NORA KUHN et al., The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases, J Virol. 2016, Vol.90, N.9, pp. 4298-4307. *
THOMAS H. BUGGE et al., Type II Transmembrane Serine Proteases, J Biol Chem., 2009, Vol. 284, N.35, pp. 23177-23181. *
THOMAS H. BUGGE et al., Type II Transmembrane Serine Proteases, J Biol Chem., 2009, Vol. 284, N.35, pp. 23177-23181. NORA KUHN et al., The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases, J Virol. 2016, Vol.90, N.9, pp. 4298-4307. *
YU SUN, Characterization of the TMPRSS2 Protease as a Modulator of Prostate Cancer Metastasis, 2009. *

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