RU2749715C2 - Грызуны, характеризующиеся гуманизированным геном tmprss - Google Patents
Грызуны, характеризующиеся гуманизированным геном tmprss Download PDFInfo
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- RU2749715C2 RU2749715C2 RU2018131152A RU2018131152A RU2749715C2 RU 2749715 C2 RU2749715 C2 RU 2749715C2 RU 2018131152 A RU2018131152 A RU 2018131152A RU 2018131152 A RU2018131152 A RU 2018131152A RU 2749715 C2 RU2749715 C2 RU 2749715C2
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| MX368931B (es) | 2013-09-23 | 2019-10-22 | Regeneron Pharma | Animales no humanos que tienen un gen de proteina reguladora de señal humanizado. |
| AU2014337526B2 (en) | 2013-10-15 | 2020-09-10 | Regeneron Pharmaceuticals, Inc. | Humanized IL-15 animals |
| US20150143558A1 (en) | 2013-11-19 | 2015-05-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| BR112016011004A2 (pt) | 2013-11-19 | 2017-12-05 | Regeneron Pharma | animal roedor geneticamente modificado, célula tronco embrionária de roedor, embrião de roedor, e, métodos para fabricar um animal roedor e para enxertar células humanas em um camundongo |
| RU2700484C2 (ru) | 2014-04-08 | 2019-09-17 | Регенерон Фармасьютикалз, Инк. | Не относящиеся к человеку животные, имеющие гуманизированные fc-гамма-рецепторы |
| NO2785538T3 (enExample) * | 2014-05-07 | 2018-08-04 | ||
| PT3482629T (pt) | 2014-05-19 | 2021-02-18 | Univ Yale | Animais não humanos geneticamente modificados que expressam epo humana |
| EP3683238A1 (en) | 2014-06-19 | 2020-07-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized programmed cell death 1 gene |
| KR102659123B1 (ko) | 2014-11-24 | 2024-04-22 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 cd3 복합체를 발현하는 비인간 동물 |
| FI3850946T3 (fi) | 2014-12-05 | 2023-12-28 | Regeneron Pharma | Ei-ihmiseläimiä, joilla on humanisoitu erilaistumisklusterin 47 geeni |
| EP3808775B1 (en) | 2014-12-09 | 2024-04-17 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| RU2732628C2 (ru) | 2015-04-06 | 2020-09-21 | Регенерон Фармасьютикалз, Инк. | Опосредованные гуманизированными т-клетками иммунные ответы у не относящихся к человеку животных |
| KR102454546B1 (ko) | 2015-11-20 | 2022-10-14 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 림프구 활성화 유전자 3을 갖는 비인간 동물 |
| EP3895529B1 (en) * | 2016-02-29 | 2026-04-29 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized tmprss gene |
| KR101693243B1 (ko) | 2016-06-15 | 2017-01-05 | 재단법인 한국파스퇴르연구소 | 인플루엔자 바이러스의 복제에 관여하는 신규 인간 유전자 및 이의 용도 |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050026255A1 (en) * | 2002-06-25 | 2005-02-03 | Morser John Michael | Corin, a serine protease |
| US20060101531A1 (en) * | 2004-08-19 | 2006-05-11 | Fred Hutchinson Cancer Research Center | Animal models of cancer development and metastasis |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
Non-Patent Citations (4)
| Title |
|---|
| NORA KUHN et al., The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases, J Virol. 2016, Vol.90, N.9, pp. 4298-4307. * |
| THOMAS H. BUGGE et al., Type II Transmembrane Serine Proteases, J Biol Chem., 2009, Vol. 284, N.35, pp. 23177-23181. * |
| THOMAS H. BUGGE et al., Type II Transmembrane Serine Proteases, J Biol Chem., 2009, Vol. 284, N.35, pp. 23177-23181. NORA KUHN et al., The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases, J Virol. 2016, Vol.90, N.9, pp. 4298-4307. * |
| YU SUN, Characterization of the TMPRSS2 Protease as a Modulator of Prostate Cancer Metastasis, 2009. * |
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