KR102661616B1 - Gpr156 변이체 및 이들의 용도 - Google Patents
Gpr156 변이체 및 이들의 용도 Download PDFInfo
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- KR102661616B1 KR102661616B1 KR1020197001965A KR20197001965A KR102661616B1 KR 102661616 B1 KR102661616 B1 KR 102661616B1 KR 1020197001965 A KR1020197001965 A KR 1020197001965A KR 20197001965 A KR20197001965 A KR 20197001965A KR 102661616 B1 KR102661616 B1 KR 102661616B1
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- gpr156
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Abstract
본 발명은 인간 G 단백질-연계된 수용체 156 단백질 (GPR156)의 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 변경을 포함하는, cDNA를 비롯한 핵산을 제공한다. 본 발명은 또한, 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 단리된 및 재조합 인간 GPR156 단백질 변이체를 제공한다. 아스파르트산으로의 변화 및 이러한 변화를 인코딩하는 유전자는 단극성 우울증과 연관된다. 본 발명은 또한, GPR156을 인코딩하는 유전자 (DNA 또는 RNA)에서 이런 변경의 확인에 근거하여, 개체가 단극성 우울증을 앓거나 또는 단극성 우울증이 발달할 위험에 처해 있는 지를 결정하기 위한 방법을 제공한다.
Description
관련된 출원에 대한 교차 참조
본 출원은 2016년 7월 28일자 제출된 U.S. 가출원 번호 62/367,973에 우선권을 주장하고, 이의 내용은 본원에서 전체적으로 및 모든 점에서 참조로서 편입된다.
서열 목록에 대한 참조
본 출원은 986 킬로바이트의 크기로 2017년 7월 28일자 작성된, 18923800702SEQ로 명명된 텍스트 파일로서 전자적으로 제출된 서열 목록을 포함한다. 상기 서열 목록은 본원에서 참조로서 편입된다.
분야
본 발명은 유전학의 분야에 전반적으로 관계한다. 더욱 구체적으로, 본 발명은 예로서, 단극성 우울증 및 불안 장애와 연관되는 G 단백질-연계된 수용체 156에서 유전자 변경 및 폴리펩티드 변이체에 관계한다.
배경
특허, 특허 출원, 수탁 번호, 기술 문헌 및 학술 문헌을 비롯한 다양한 참고문헌이 명세서 전반에서 인용된다. 각 참고문헌은 본원에서 전체적으로 및 모든 점에서 참조로서 편입된다.
G 단백질-연계된 수용체 (GPCRs)는 N 말단 세포외 도메인 및 C 말단 세포내 도메인과 함께, 7개의 나선형 막경유 도메인에 의해 특징되는 세포 표면 수용체의 큰 상과이다 (Cherezov V, et al., Science 318: 1258-1265 (2007)). GPCRs는 다양한 세포 유형에서 발현되고, 그리고 세포 막을 교차하여 및 세포 내부로 세포외 신호를 전달하는데 참여한다 (Kobilka R, Biochim. Biophys. Acta 1768: 794-807 (2007)). GPCRs가 생물학에서 수행하는 역할이 매우 중요하기 때문에, 2012년 노벨 화학상이 GPCRs가 어떻게 기능하는 지를 확인한 2명의 과학자에게 수여되었다 (Clark R, Proc. Natl. Acad. Sci. USA 110: 5274-5275 (2013)).
GPR156 (G 단백질-연계된 수용체 156)은 대사성 글루타민산염 수용체 아과에 속하는 GPCR을 인코딩하는 인간 유전자이다 (Calver A, et al., Brain Res. Mol. Brain Res. 110: 305-307 (2003)). 기존 문헌에서 GPR156을 언급하는데 이용된 다른 명칭은 GABABL (GABAB-유사) 및 PGR28이다 (Vassilatis D, Proc. Natl. Acad. Sci. USA 100: 4903-4908 (2003)). 생쥐에서, GPR156은 Gpr156 또는 Gababl로서 지칭된다. 새로운 GPR156 변이체를 확인하는 것은 인간 생리학에서 GPR156의 역할 및 질환에서 이의 잠재적 역할에 관한 지속적인 연구에 도움이 될 것이다. 본 발명은 GPR156의 생물학을 이해하는데 보조하고, 그리고 GPR156 및/또는 이의 세포 생물학적 경로를 조정하는 잠재적인 치료적 작용제의 확인을 용이하게 할 신규한 GPR156 변이체를 제공한다.
요약
본 발명은 다양한 기분 장애, 예를 들면, 우울증, 예를 들면, 단극성 우울증, 그리고 불안 장애와 연관되는 것으로 본원에서 증명된 GPR156 변이체 폴리펩티드를 인코딩하는 신규한 핵산 분자 (다시 말하면, 유전체 DNA, mRNA 및 cDNA) 및 GPR156 변이체 폴리펩티드를 제공한다.
본 발명은 인간 GPR156 단백질을 인코딩하는 핵산 서열, 또는 상기 핵산 서열의 보체를 포함하는 단리된 핵산 분자를 제공하는데, 여기서 상기 단백질은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다.
본 발명은 또한, 인간 GPR156 단백질의 최소한 일부를 인코딩하는 핵산 서열, 또는 상기 핵산 서열의 보체를 포함하는 유전체 DNA 분자를 제공하는데, 여기서 상기 일부는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다.
본 발명은 또한, 인간 GPR156 단백질의 최소한 일부를 인코딩하는 핵산 서열, 또는 상기 핵산 서열의 보체를 포함하는 cDNA 분자를 제공하는데, 여기서 상기 일부는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다.
본 발명은 또한, 인간 GPR156 단백질의 최소한 일부를 인코딩하는 핵산 서열, 또는 상기 핵산 서열의 보체를 포함하는 mRNA 분자를 제공하는데, 여기서 상기 일부는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다.
본 발명은 또한, 본원에서 개시된 단리된 핵산 분자 중에서 한 가지를 포함하는 벡터를 제공한다.
본 발명은 또한, 본원에서 개시된 단리된 핵산 분자 또는 벡터 중에서 한 가지를 및 담체를 포함하는 조성물을 제공한다.
본 발명은 또한, 본원에서 개시된 단리된 핵산 분자 또는 벡터 중에서 한 가지를 포함하는 숙주 세포를 제공한다.
본 발명은 또한, 인간 GPR156 단백질의 최소한 일부를 포함하는 단리된 또는 재조합 폴리펩티드를 제공하는데, 여기서 상기 일부는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다.
본 발명은 또한, 본원에서 개시된 단리된 또는 재조합 폴리펩티드 중에서 한 가지 및 담체를 포함하는 조성물을 제공한다.
본 발명은 또한, 최소한 약 5개의 뉴클레오티드를 포함하는 핵산 서열을 포함하는 프로브 또는 프라이머를 제공하는데, 이것은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 인간 GPR156 단백질을 인코딩하는 핵산 서열에 혼성화하거나, 또는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 인간 GPR156 단백질을 인코딩하는 핵산 서열의 보체에 혼성화한다.
본 발명은 또한, 본원에서 개시된 프로브 중에서 한 가지가 혼성화하는 기질을 포함하는 지지체를 제공한다.
본 발명은 또한, GPR156 단백질을 인코딩하는 핵산 서열에 상보적인 핵산 서열을 포함하는 대립유전자-특이적 프로브 또는 프라이머를 제공하는데, 여기서 상기 대립유전자-특이적 프로브 또는 프라이머는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 핵산 코돈에 상보적인 핵산 서열을 포함한다. 일부 구체예에서, 대립유전자-특이적 프로브 또는 프라이머는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 GPR156 단백질을 인코딩하는 핵산 서열, 또는 이의 보체에 특이적으로 혼성화한다. 대립유전자-특이적 프로브 또는 프라이머는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하지 않는 GPR156 단백질을 인코딩하는 핵산 서열에 혼성화하지 않는다.
본 발명은 또한, 인간 개체에서 단극성 우울증을 진단하거나 또는 단극성 우울증의 위험을 검출하기 위한 방법을 제공하는데, 이들 방법은 인간 개체로부터 획득된 GPR156 단백질을 인코딩하는 핵산 분자에서 변경을 검출하고, 여기서 상기 변경은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하고; 그리고 만약 개체가 우울증의 하나 또는 그 이상의 증상을 앓으면 인간 개체를 단극성 우울증을 앓는 것으로 진단하고, 또는 만약 개체가 우울증의 하나 또는 그 이상의 증상을 앓지 않으면 인간 개체를 단극성 우울증의 위험에 처해있는 것으로 진단하는 것을 포함한다.
본 발명은 또한, 인간 개체에서 불안 장애를 진단하거나 또는 불안 장애의 위험을 검출하기 위한 방법을 제공하는데, 이들 방법은 인간 개체로부터 획득된 GPR156 단백질을 인코딩하는 핵산 분자에서 변경을 검출하고, 여기서 상기 변경은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하고; 그리고 만약 개체가 불안 장애의 하나 또는 그 이상의 증상을 앓으면 인간 개체를 불안 장애를 앓는 것으로 진단하고, 또는 만약 개체가 불안 장애의 하나 또는 그 이상의 증상을 앓지 않으면 인간 개체를 불안 장애의 위험에 처해있는 것으로 진단하는 것을 포함한다.
본 발명은 또한, 인간 GPR156 단백질을 인코딩하는 유전자에서 변경을 포함하는 것으로 결정된 인간 개체에서 단극성 우울증의 치료에서 이용을 위한 항우울제를 제공하는데, 여기서 상기 변경은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩한다.
본 발명은 또한, 인간 GPR156 단백질을 인코딩하는 유전자에서 변경을 포함하는 것으로 결정된 인간 개체에서 불안 장애의 치료에서 이용을 위한 항우울제를 제공하는데, 여기서 상기 변경은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩한다.
도면의 간단한 설명
본 명세서에 통합되고 본 명세서의 일부를 구성하는 첨부 도면은 여러 양상을 예시하고, 그리고 상세한 설명과 함께, 본 발명의 원리를 설명하는데 조력한다.
도면 1은 mRor1ss.hGPR156 발현 벡터의 벡터 지도를 보여준다.
도면 2는 mRor1ss.hGPR156_E533D 발현 벡터의 벡터 지도를 보여준다.
본 발명의 추가 이점은 부분적으로는 다음의 설명에서 진술될 것이고, 그리고 부분적으로는 상기 설명으로부터 명백하거나, 또는 본원에서 개시된 구체예의 실시에 의해 학습될 수 있다. 본 발명의 이점은 특히 첨부된 청구항에서 지적된 요소와 조합에 의하여 실현되고 획득될 것이다. 전술한 일반적인 설명 및 아래의 상세한 설명 둘 모두 단지 예시이고 설명적이고, 그리고 청구된 바와 같은 구체예를 한정하지 않는 것으로 이해된다.
본 명세서에 통합되고 본 명세서의 일부를 구성하는 첨부 도면은 여러 양상을 예시하고, 그리고 상세한 설명과 함께, 본 발명의 원리를 설명하는데 조력한다.
도면 1은 mRor1ss.hGPR156 발현 벡터의 벡터 지도를 보여준다.
도면 2는 mRor1ss.hGPR156_E533D 발현 벡터의 벡터 지도를 보여준다.
본 발명의 추가 이점은 부분적으로는 다음의 설명에서 진술될 것이고, 그리고 부분적으로는 상기 설명으로부터 명백하거나, 또는 본원에서 개시된 구체예의 실시에 의해 학습될 수 있다. 본 발명의 이점은 특히 첨부된 청구항에서 지적된 요소와 조합에 의하여 실현되고 획득될 것이다. 전술한 일반적인 설명 및 아래의 상세한 설명 둘 모두 단지 예시이고 설명적이고, 그리고 청구된 바와 같은 구체예를 한정하지 않는 것으로 이해된다.
설명
개시의 양상에 관련된 다양한 용어가 명세서 및 청구항 전반에서 이용된다. 이런 용어는 달리 지시되지 않으면, 당해 분야에서 그들의 일상적인 의미가 제공된다. 다른 특이적으로 규정된 용어는 본원에서 제공된 정의와 일치하는 방식으로 해석된다.
달리 명시적으로 언급되지 않으면, 본원에서 진술된 임의의 방법 또는 양상은 이의 단계가 특정한 순서로 수행될 필요가 있는 것으로 결코 해석되지 않아야 한다. 따라서, 방법 청구항이 청구항 또는 설명에서, 이들 단계가 특정한 순서로 한정되어야 한다고 특정적으로 진술하지 않는 경우에, 순서가 어떤 면에서 보더라도 암시되는 것으로 의도되지 않는다. 이것은 단계의 배열 또는 작업 순서(operational flow), 문법적 구성 또는 구두점으로부터 유추되는 있는 그대로의 의미, 또는 본 명세서에 설명된 양상의 숫자 또는 유형과 관련한 논리의 문제를 비롯하여, 해석을 위한 임의의 가능한 비명시적 근거에도 마찬가지다
본원에서 이용된 바와 같이, 단수 형태 ("a", "an" 및 "the")는 문맥에서 달리 지시되지 않으면, 복수 지시대상을 포함한다.
본원에서 이용된 바와 같이, 용어 "개체" 및 "환자"는 교체가능하게 이용된다. 개체는 포유동물을 비롯한 임의의 동물을 포함할 수 있다. 포유동물은 제한 없이, 경작용 동물 (가령, 말, 소, 돼지), 반려 동물 (가령, 개, 고양이), 실험 동물 (가령, 생쥐, 쥐, 토끼), 그리고 비인간 영장류를 포함한다. 일부 구체예에서, 개체는 인간이다.
본원에서 이용된 바와 같이, "핵산," "핵산 분자," "핵산 서열," "폴리뉴클레오티드," 또는 "올리고뉴클레오티드"는 임의의 길이의 뉴클레오티드의 중합성 형태를 포함할 수 있고, DNA 및/또는 RNA를 포함할 수 있고, 그리고 단일 가닥, 이중 가닥, 또는 복수 가닥일 수 있다. 핵산의 한쪽 가닥은 또한, 이의 보체를 지칭한다.
본원에서 이용된 바와 같이, 소정의 아미노산 또는 핵산 서열 또는 위치의 넘버링의 맥락에서 이용될 때 관용구 "상응하는" 또는 이의 문법적 변이는 소정의 아미노산 또는 핵산 서열이 참고 서열 (가령, 본원에서 (야생형 또는 전장) GPR156의 핵산 분자 또는 폴리펩티드인 참고 서열)과 비교될 때, 특정된 참고 서열의 넘버링을 지칭한다. 다시 말하면, 소정의 중합체의 잔기 (가령, 아미노산 또는 뉴클레오티드) 번호 또는 잔기 (가령, 아미노산 또는 뉴클레오티드) 위치는 소정의 아미노산 또는 핵산 서열 내에 잔기의 실제 수치 위치에 의하기 보다는 참고 서열에 대하여 지정된다. 가령, 소정의 아미노산 서열은 이들 두 서열 사이에 잔기 정합을 최적화하기 위한 갭을 도입함으로써 참고 서열에 맞춰 정렬될 수 있다. 이들 사례에서, 비록 갭이 존재하긴 하지만, 소정의 아미노산 또는 핵산 서열에서 잔기의 넘버링은 이것이 맞춰 정렬된 참고 서열에 대하여 만들어진다.
가령, 관용구 "GPR156 단백질, 여기서 상기 단백질은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다"는 GPR156 단백질의 아미노산 서열이 서열 번호:4의 서열에 맞춰 정렬되면, GPR156 단백질이 서열 번호:4의 위치 533에 상응하는 위치에서 아스파르트산을 갖는다는 것을 의미한다. 관용구 "GPR156 단백질, 여기서 상기 단백질은 서열 번호:4를 참조하는 위치 533에 상응하는 위치에서 아스파르트산을 포함한다" 및 "GPR156 단백질, 여기서 상기 단백질은 서열 번호:4의 위치 533에 상응하는 위치에서 아스파르트산을 포함한다"에도 동일하게 적용된다. 또는 다시 말하면, 이들 관용구 (가령, 관용구 "GPR156 단백질, 여기서 상기 단백질은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다")는 서열 번호:4의 위치 533에서 아스파르트산에 상동하는 아스파르트산을 갖는 GPR156 단백질을 지칭한다. 본원에서 이런 단백질은 "E533D 돌연변이를 갖는 GPR156 단백질" 또는 "E533D 변이를 갖는 GPR156 단백질"로서 또한 지칭된다. 이것과 일관하게, 상응하는 E533D 변이는 "E533D 돌연변이 (GPR156 단백질 내에)" 또는 "E533D 변이 (GPR156 단백질 내에)"로서 또한 지칭된다.
전술된 바와 같이, 서열 번호:4의 위치 533에 상응하는 GPR156 단백질 내에 위치는 소정의 GPR156 단백질 및 서열 번호:4의 아미노산 서열 사이에 서열 정렬을 수행함으로써 쉽게 확인될 수 있다. 서열 번호:4에서 위치 533에 상응하는 아미노산 위치를 확인하기 위한 서열 정렬을 수행하는데 이용될 수 있는 다양한 연산적 알고리즘이 존재한다. 가령, NCBI BLAST 알고리즘 (Altschul et al. 1997 Nucleic Acids Res. 25: 3389-3402) 또는 CLUSTALW 소프트웨어 (Sievers and Higgins 2014 Methods Mol. Biol. 1079: 105-116.)을 이용함으로써, 서열 정렬이 수행될 수 있다. 하지만, 서열은 또한, 수동으로 정렬될 수 있다.
본 발명에 따라서, GPR156에서 일정한 변이는 기분 장애, 예를 들면, 단극성 우울증 및 불안 장애가 발달할 위험과 연관되는 것으로 관찰되었다. 일반적으로, 이러한 단백질의 기능은 잘 이해되지 않는데, 이의 생화학 또는 이의 연관된 표현형에 관해 공개된 정보는 거의 없다. GPR156 유전자 또는 단백질의 어떤 변이체도 성인에서 임의의 기분 또는 신경학적 장애와 임의의 공지된 연관을 갖지 않는 것으로 생각된다. GPR156 유전자 또는 단백질의 어떤 변이체도 성인에서 일반적으로 우울증 또는 특정적으로 단극성 우울증 또는 불안 장애와 임의의 공지된 연관을 갖지 않는 것으로 더욱 생각된다. 영향을 받은 가족 구성원에서 단극성 우울증의 표현형으로 분리하는 GPR156 유전자에서 희귀한 변이체가 본 발명에 따라서 확인되었다. 가령, 인간 GPR156 단백질 (가령, 야생형 서열 번호:1)에서 위치 533의 아미노산을 아스파르트산으로 변화시키는 유전적 변경은 이런 변경을 갖는 인간은 단극성 우울증이 발달할 수 있다는 것을 지시하는 것으로 관찰되었다. 종합하면, 본원에서 설명된 유전자 분석은 놀랍게도, GPR156 유전자, 그리고 특히, GPR156에서 변이체가 단극성 우울증 및 불안 장애에 대한 증가된 감수성과 연관된다는 것을 지시한다. 이런 이유로, 단극성 우울증 또는 불안 장애와 연관되는 GPR 156 변경을 갖는 인간 개체는 단극성 우울증이 저해되고, 이의 증상이 감소되고 및/또는 증상의 발달이 억제되도록 치료될 수 있다. 따라서, 본 발명은 cDNA 및 mRNA뿐만 아니라 단리된 또는 재조합 GPR156 변이체 폴리펩티드를 비롯하여, 단리된 또는 재조합 GPR156 변이체 유전자를 제공한다. 추가적으로, 본 발명은 활성 질환을 앓을 위험에 처해있는 개체 또는 활성 질환을 앓는 개체가 치료될 수 있도록, 이런 개체에서 단극성 우울증 또는 불안 장애가 발달하는 위험을 확인하거나 또는 층화하기 위해, 또는 개체를 단극성 우울증 또는 불안 장애를 앓는 것으로 진단하기 위해, 개체에서 이런 변이체의 확인을 레버리징하기 위한 방법을 제공한다.
2개의 전장 야생형 GPR156 단백질에 대한 아미노산 서열은 서열 번호:1에서 진술된다. 서열 번호:1을 참조하면, 전장 야생형 GPR156 단백질의 위치 516은 글루타민산 또는 아스파르트산이다. 다른 야생형 GPR156 단백질의 아미노산 서열은 서열 번호:2 (이것은 서열 번호:1의 위치 198 내지 201에 상응하는 위치에서 4개 아미노산의 결실을 내포한다)에서 진술된다. 이러한 야생형 GPR156 단백질의 위치 512 (서열 번호:2 참조)는 글루타민산 또는 아스파르트산이다. 일부 구체예에서, 이러한 야생형 GPR156 단백질의 위치 512 (서열 번호:2 참조)는 글루타민산이다. 일부 구체예에서, 이러한 야생형 GPR156 단백질의 위치 512 (서열 번호:2 참조)는 아스파르트산이다. 서열 번호:1의 위치 310 내지 814를 포함하는 GPR156 단백질의 아미노산 서열은 서열 번호:3에서 진술된다. 서열 번호:1의 위치 310 내지 814는 GPR156의 세포질 도메인을 규정한다. 이러한 GPR156 단백질의 위치 207 (서열 번호:3 참조)은 글루타민산 또는 아스파르트산이다. 일부 구체예에서, 이러한 GPR156 단백질의 위치 207 (서열 번호:3 참조)은 글루타민산이다. 일부 구체예에서, 이러한 GPR156 단백질의 위치 207 (서열 번호:3 참조)은 아스파르트산이다.
본 발명은 단극성 우울증 또는 불안 장애와 연관되는 GPR156 변이체 단백질을 인코딩하는 핵산 분자를 제공한다. 가령, 본 발명은 인간 GPR156 단백질을 인코딩하는 핵산 서열, 또는 상기 핵산 서열의 보체를 포함하는 단리된 핵산 분자를 제공하는데, 여기서 상기 단백질은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산 (E533D)을 포함한다. 일부 구체예에서, 서열 번호:4의 위치 516에 상응하는 위치는 글루타민산이다. 일부 구체예에서, 서열 번호:4의 위치 516에 상응하는 위치는 아스파르트산이다.
GPR156의 동종형이 존재하는데, 여기서 상기 단백질의 N 말단에서 중심 영역으로 4개 아미노산이 결실된다. 이러한 GPR156 동종형의 아미노산 서열은 서열 번호:5에서 도시된다. 이러한 GPR156 동종형에서 위치 529는 서열 번호:4에 따른 위치 533에 상응한다. 일부 구체예에서, 단리된 핵산 분자는 인간 GPR156 단백질을 인코딩하는 핵산 서열, 또는 상기 핵산 서열의 보체를 포함하고, 여기서 상기 단백질은 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산 (E529D)을 포함한다. 일부 구체예에서, 서열 번호:5의 위치 512는 글루타민산이다. 일부 구체예에서, 서열 번호:5의 위치 512에 상응하는 위치는 아스파르트산이다.
일부 구체예에서, 핵산 분자는 서열 번호:4에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 아미노산 서열을 갖는 인간 GPR156 단백질을 인코딩하는 핵산 서열, 또는 상기 핵산 서열의 보체를 포함하거나 또는 이것으로 구성되는데, 여기서 상기 GPR156 단백질은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다. 일부 구체예에서, 이러한 핵산 분자의 위치 516 (서열 번호:4 참조)에 상응하는 위치는 글루타민산이다. 일부 구체예에서, 이러한 핵산 분자의 위치 516 (서열 번호:4 참조)에 상응하는 위치는 아스파르트산이다. 본원에서, 서열 동일성 퍼센트가 언급되면, 서열 동일성의 더욱 높은 백분율이 더욱 낮은 백분율보다 선호된다.
일부 구체예에서, 핵산 분자는 서열 번호:5에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 아미노산 서열을 갖는 인간 GPR156 단백질을 인코딩하는 핵산 서열, 또는 상기 핵산 서열의 보체를 포함하거나 또는 이것으로 구성되는데, 여기서 상기 GPR156 단백질은 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 포함한다. 일부 구체예에서, 이러한 GPR156 단백질의 위치 512 (서열 번호:5 참조)에 상응하는 위치는 글루타민산이다. 일부 구체예에서, 이러한 GPR156 단백질의 위치 512 (서열 번호:5 참조)에 상응하는 위치는 아스파르트산이다.
일부 구체예에서, 핵산 서열은 DNA를 포함하고, 그리고 위치 533에 상응하는 위치에서 아스파르트산은 코돈 GAT 또는 GAC에 의해 인코딩된다. 일부 구체예에서, 핵산 서열은 RNA를 포함하고, 그리고 위치 533에 상응하는 위치에서 아스파르트산은 RNA 분자에서 코돈 GAU 또는 GAC에 의해 인코딩된다. 일부 구체예에서, 위치 533에 상응하는 위치에서 아스파르트산은 코돈 GAT에 의해 인코딩된다. 일부 구체예에서, 핵산 서열에 의해 인코딩된 GPR156 단백질은 서열 번호:4 또는 서열 번호:5의 아미노산 서열을 포함한다.
2개의 야생형 GPR156 유전체 DNA (다시 말하면, 대체 대립유전자)에 대한 핵산 서열은 서열 번호:7에서 진술된다 (a, g, t 또는 c일 수 있는, 위치 117,166에서 "n"을 참조한다). 이들 야생형 GPR156 유전체 DNA의 위치 117,164 내지 117,166 (서열 번호:7 참조)은 글루타민산 (코돈 GAA 또는 GAG을 통해) 또는 아스파르트산 (코돈 GAT 또는 GAC를 통해)을 인코딩한다. 이들 야생형 GPR156 유전체 DNA의 위치 117,215 내지 117,217 (서열 번호:7 참조)은 글루타민산 (코돈 GAA 또는 GAG를 통해)을 인코딩한다.
다른 야생형 GPR156 유전체 DNA의 핵산 서열은 서열 번호:8 (이것은 서열 번호:7의 위치 98,428 내지 98,439에 상응하는 위치에서 12개 뉴클레오티드의 결실을 내포한다)에서 진술된다. 이러한 야생형 GPR156 유전체 DNA의 위치 117,152 내지 117,154 (서열 번호:8 참조)는 글루타민산 (코돈 GAA 또는 GAG을 통해) 또는 아스파르트산 (코돈 GAT 또는 GAC를 통해)을 인코딩한다. 이러한 야생형 GPR156 유전체 DNA의 위치 117,203 내지 117,205 (서열 번호:8 참조)는 글루타민산 (코돈 GAA 또는 GAG를 통해)을 인코딩한다.
일부 구체예에서, 핵산 분자는 유전체 DNA이다. 일부 구체예에서, 유전체 DNA는 서열 번호:9 (여기서 위치 117,215 내지 117,217은 GAT이고, 따라서 아스파르트산을 인코딩한다) 또는 서열 번호:10 (여기서 위치 117,215 내지 117,217은 GAC이고, 따라서 아스파르트산을 인코딩한다)의 핵산 서열, 또는 서열 번호:9 (그리고, 서열 번호:4에 따른 위치 533에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAT 코돈을 포함한다) 또는 서열 번호:10 (그리고, 서열 번호:4에 따른 위치 533에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAC 코돈을 포함한다)에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 핵산 서열을 포함하거나 또는 이것으로 구성된다. 일부 구체예에서, 이들 GPR156 유전체 DNA의 위치 117,164 내지 117,166 (서열 번호:9 및 서열 번호:10 참조)은 글루타민산 (코돈 GAA 또는 GAG를 통해)을 인코딩한다. 일부 구체예에서, 이들 GPR156 유전체 DNA의 위치 117,164 내지 117,166 (서열 번호:9 및 서열 번호:10 참조)에 상응하는 위치는 아스파르트산 (코돈 GAT 또는 GAC를 통해)을 인코딩한다.
일부 구체예에서, 유전체 DNA는 서열 번호:11 또는 서열 번호:12의 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 이들은 각각, 서열 번호:9 및 서열 번호:10의 위치 98,428 내지 98,439에 상응하는 위치에서 12개 뉴클레오티드의 결실을 내포한다. 일부 구체예에서, 유전체 DNA는 서열 번호:11에서 진술된 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 위치 117,203 내지 117,205는 GAT이고, 따라서 아스파르트산을 인코딩한다. 일부 구체예에서, 유전체 DNA는 서열 번호:12에서 진술된 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 위치 117,203 내지 117,205는 GAC이고, 따라서 아스파르트산을 인코딩한다. 일부 구체예에서, 유전체 DNA는 서열 번호:11 (그리고, 서열 번호:5에 따른 위치 529에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAT 코돈을 포함한다) 또는 서열 번호:12 (그리고, 서열 번호:5에 따른 위치 529에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAC 코돈을 포함한다)에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 핵산 서열을 포함하거나 또는 이것으로 구성된다. 일부 구체예에서, 이들 GPR156 유전체 DNA의 위치 117,152 내지 117,154 (서열 번호:11 및 서열 번호:12 참조)에 상응하는 위치는 글루타민산 (코돈 GAA 또는 GAG를 통해)을 인코딩한다. 일부 구체예에서, 이들 GPR156 유전체 DNA의 위치 117,152 내지 117,154 (서열 번호:11 및 서열 번호:12 참조)에 상응하는 위치는 아스파르트산 (코돈 GAT 또는 GAC를 통해)을 인코딩한다.
일부 구체예에서, 단리된 핵산 분자는 전체 유전체 DNA 서열보다 적은 서열을 포함한다. 일부 구체예에서, 단리된 핵산 분자는 서열 번호:9, 서열 번호:10, 서열 번호:11, 또는 서열 번호:12의 최소한 약 15개, 최소한 약 20개, 최소한 약 25개, 최소한 약 30개, 최소한 약 35개, 최소한 약 40개, 최소한 약 45개, 최소한 약 50개, 최소한 약 60개, 최소한 약 70개, 최소한 약 80개, 최소한 약 90개, 최소한 약 100개, 최소한 약 200개, 최소한 약 300개, 최소한 약 400개, 최소한 약 500개, 최소한 약 600개, 최소한 약 700개, 최소한 약 800개, 최소한 약 900개, 최소한 약 1000개, 최소한 약 2000개, 최소한 약 3000개, 최소한 약 4000개, 최소한 약 5000개, 최소한 약 6000개, 최소한 약 7000개, 최소한 약 8000개, 최소한 약 9000개, 최소한 약 10000개, 최소한 약 11000개, 최소한 약 12000개, 최소한 약 13000개, 최소한 약 14000개, 최소한 약 15000개, 최소한 약 16000개, 최소한 약 17000개, 최소한 약 18000개, 최소한 약 19000개, 또는 최소한 약 20000개의 인접한 뉴클레오티드를 포함하거나 또는 이들로 구성된다. 일부 구체예에서, 단리된 핵산 분자는 서열 번호:9, 서열 번호:10, 서열 번호:11, 또는 서열 번호:12의 최소한 약 1000개 내지 최소한 약 2000개의 인접한 뉴클레오티드를 포함하거나 또는 이들로 구성된다.
일부 구체예에서, 단리된 핵산 분자는 서열 번호:9, 서열 번호:10, 서열 번호:11, 또는 서열 번호:12의 최소한 약 15개, 최소한 약 20개, 최소한 약 25개, 최소한 약 30개, 최소한 약 35개, 최소한 약 40개, 최소한 약 45개, 최소한 약 50개, 최소한 약 60개, 최소한 약 70개, 최소한 약 80개, 최소한 약 90개, 최소한 약 100개, 최소한 약 200개, 최소한 약 300개, 최소한 약 400개, 최소한 약 500개, 최소한 약 600개, 최소한 약 700개, 최소한 약 800개, 최소한 약 900개, 최소한 약 1000개, 최소한 약 1000개, 최소한 약 1100개, 최소한 약 1200개, 최소한 약 1300개, 최소한 약 1400개, 최소한 약 1500개, 최소한 약 1600개, 최소한 약 1700개, 최소한 약 1800개, 최소한 약 1900개, 최소한 약 2000개, 최소한 약 2100개, 최소한 약 2200개, 최소한 약 2300개, 또는 최소한 약 2400개의 인접한 뉴클레오티드를 포함하거나 또는 이들로 구성된다. 일부 구체예에서, 이런 인접한 뉴클레오티드는 본원에서 설명된 cDNA 분자를 생산하기 위해 인접한 뉴클레오티드의 다른 핵산 분자와 조합될 수 있다.
이런 단리된 핵산 분자는 예로서, 변이체 GPR156 mRNA 및 단백질을 외인성 공여자 서열로서 발현하는데 이용될 수 있다. 개체군 내에서 유전자 서열은 다형성, 예를 들면, SNPs로 인해 변할 수 있는 것으로 이해된다. 본원에서 제공된 실례는 단지 예시적인 서열이고, 그리고 다른 서열 역시 가능하다.
일부 구체예에서, 단리된 핵산 분자는 변이체 GPR156 꼬마유전자를 포함하는데, 여기서 서열 번호:4 또는 서열 번호:5를 인코딩하는 하나 또는 그 이상의 비필수적인 분절이 상응하는 야생형 GPR156 유전자에 비하여 결실되었다. 일부 구체예에서, 결실된 비필수적인 분절은 하나 또는 그 이상의 인트론 서열을 포함한다. 일부 구체예에서, GPR156 꼬마유전자는 서열 번호:9, 서열 번호:10, 서열 번호:11, 또는 서열 번호:12의 부분에 최소한 약 70%, 최소한 약 75%, 최소한 약 80%, 최소한 약 85%, 최소한 약 90%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 최소한 약 99%, 또는 100% 서열 동일성을 갖는데, 여기서 상기 꼬마유전자는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다.
2개의 야생형 GPR156 cDNA에 대한 핵산 서열은 서열 번호:13에서 진술된다. 이들 야생형 GPR156 cDNA의 위치 1546 내지 1548 (서열 번호:13 참조)은 글루타민산 (코돈 GAA 또는 GAG을 통해) 또는 아스파르트산 (코돈 GAT 또는 GAC를 통해)을 인코딩한다. 이들 야생형 GPR156 cDNA의 위치 1597 내지 1599 (서열 번호:13 참조)는 글루타민산 (코돈 GAA 또는 GAG를 통해)을 인코딩한다.
다른 야생형 GPR156 cDNA의 핵산 서열은 서열 번호:14 (이것은 서열 번호:13의 위치 592-603에 상응하는 위치에서 12개 뉴클레오티드의 결실을 내포한다)에서 진술된다. 이러한 야생형 GPR156 cDNA의 위치 1534 내지 1536 (서열 번호:14 참조)은 글루타민산 (코돈 GAA 또는 GAG을 통해) 또는 아스파르트산 (코돈 GAT 또는 GAC를 통해)을 인코딩한다. 이러한 야생형 GPR156 cDNA의 위치 1585 내지 1587 (서열 번호:14 참조)은 글루타민산 (코돈 GAA 또는 GAG를 통해)을 인코딩한다.
서열 번호:4의 위치 310 내지 814를 인코딩하는 GPR156 cDNA의 핵산 서열은 서열 번호:15에서 진술된다. 이러한 서열은 GPR156의 세포질 도메인에 상응한다. 이러한 GPR156 cDNA의 위치 619 내지 621 (서열 번호:15 참조)은 글루타민산 (코돈 GAA 또는 GAG을 통해) 또는 아스파르트산 (코돈 GAT 또는 GAC를 통해)을 인코딩한다. 이러한 GPR156 cDNA의 위치 670 내지 672 (서열 번호:15 참조)는 글루타민산 (코돈 GAA 또는 GAG를 통해)을 인코딩한다.
본 발명은 또한 cDNA 분자를 제공한다. 본 발명은 인간 GPR156 단백질의 최소한 일부를 인코딩하는 핵산 서열을 포함하는 cDNA 분자를 제공하는데, 여기서 상기 일부는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다. 일부 구체예에서, cDNA 분자는 인간 GPR156 단백질의 최소한 일부를 인코딩하는 핵산 서열을 포함하는데, 여기서 상기 일부는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 포함한다.
일부 구체예에서, cDNA는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 전장 인간 GPR156 단백질을 인코딩한다. 일부 구체예에서, cDNA는 서열 번호:4에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 아미노산 서열을 갖는 폴리펩티드를 인코딩하는 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 상기 GPR156 단백질은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다.
일부 구체예에서, cDNA는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 포함하는 인간 GPR156 단백질을 인코딩한다. 일부 구체예에서, cDNA는 서열 번호:5에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 아미노산 서열을 갖는 폴리펩티드를 인코딩하는 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 상기 GPR156 단백질은 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 포함한다.
일부 구체예에서, cDNA는 서열 번호:4의 위치 310 내지 814에 상응하는 GPR156 단백질의 일부를 인코딩한다. 일부 구체예에서, cDNA는 서열 번호:4의 위치 310 내지 814에 상응하는 GPR156 단백질의 일부에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 아미노산 서열을 갖는 폴리펩티드를 인코딩하는 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 상기 폴리펩티드는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다.
일부 구체예에서, cDNA는 서열 번호:5의 위치 310 내지 814에 상응하는 GPR156 단백질의 일부를 인코딩한다. 일부 구체예에서, cDNA는 서열 번호:5의 위치 310 내지 814에 상응하는 GPR156 단백질의 일부에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 아미노산 서열을 갖는 폴리펩티드를 인코딩하는 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 상기 폴리펩티드는 서열 번호:5에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다.
일부 구체예에서, cDNA는 서열 번호:16의 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 위치 1597 내지 1599는 GAT이고, 따라서 아스파르트산을 인코딩한다. 일부 구체예에서, cDNA는 서열 번호:16에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 핵산 서열을 포함하거나 또는 이것으로 구성되고, 그리고 서열 번호:4에 따른 위치 533에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAT 코돈을 포함한다). 일부 구체예에서, GPR156 cDNA의 위치 1546 내지 1548 (서열 번호:16 참조)에 상응하는 위치는 글루타민산을 인코딩한다. 일부 구체예에서, GPR156 cDNA의 위치 1546 내지 1548 (서열 번호:16 참조)에 상응하는 위치는 아스파르트산을 인코딩한다. 일부 구체예에서, cDNA는 GPR156 cDNA의 위치 1599 (서열 번호:16 참조)에 상응하는 위치에서 티민을 포함한다. 이러한 티민은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈의 세 번째 위치에 상응한다).
일부 구체예에서, cDNA는 서열 번호:17의 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 위치 1597 내지 1599는 GAC이고, 따라서 아스파르트산을 인코딩한다. 일부 구체예에서, cDNA는 서열 번호:17에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 핵산 서열을 포함하거나 또는 이것으로 구성되고, 그리고 서열 번호:4에 따른 위치 533에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAC 코돈을 포함한다). 일부 구체예에서, GPR156 cDNA의 위치 1546 내지 1548 (서열 번호:17 참조)에 상응하는 위치는 글루타민산을 인코딩한다. 일부 구체예에서, GPR156 cDNA의 위치 1546 내지 1548 (서열 번호:17 참조)는 아스파르트산을 인코딩한다. 일부 구체예에서, cDNA는 GPR156 cDNA의 위치 1599 (서열 번호:17 참조)에 상응하는 위치에서 시토신을 포함한다. 이러한 시토신은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈의 세 번째 위치에 상응한다).
일부 구체예에서, cDNA는 서열 번호:16의 위치 592 내지 603에 상응하는 위치에서 12개 뉴클레오티드의 결실을 내포하는 서열 번호:18의 핵산 서열을 포함하거나 또는 이것으로 구성된다. 일부 구체예에서, cDNA는 서열 번호:18에서 진술된 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 위치 1585 내지 1587은 GAT이고, 따라서 아스파르트산을 인코딩한다. 일부 구체예에서, cDNA는 서열 번호:18에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 핵산 서열을 포함하거나 또는 이것으로 구성된다 (그리고, 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAT 코돈을 포함한다). 일부 구체예에서, 이러한 GPR156 cDNA의 위치 1534 내지 1536 (서열 번호:18 참조)에 상응하는 위치는 글루타민산 (코돈 GAA 또는 GAG를 통해)을 인코딩한다. 일부 구체예에서, 이러한 GPR156 cDNA의 위치 1534 내지 1536 (서열 번호:18 참조)에 상응하는 위치는 아스파르트산 (코돈 GAT 또는 GAC를 통해)을 인코딩한다. 일부 구체예에서, cDNA는 GPR156 cDNA의 위치 1587 (서열 번호:18 참조)에 상응하는 위치에서 티민을 포함한다. 이러한 티민은 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈의 세 번째 위치에 상응한다).
일부 구체예에서, cDNA는 서열 번호:17의 위치 592 내지 603에 상응하는 위치에서 12개 뉴클레오티드의 결실을 내포하는 서열 번호:19의 핵산 서열을 포함하거나 또는 이것으로 구성된다. 일부 구체예에서, cDNA는 서열 번호:19에서 진술된 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 위치 1585 내지 1587은 GAC이고, 따라서 아스파르트산을 인코딩한다. 일부 구체예에서, cDNA는 서열 번호:19에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 핵산 서열을 포함하거나 또는 이것으로 구성된다 (그리고, 서열 번호:5에 따른 위치 529에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAC 코돈을 포함한다). 일부 구체예에서, 이러한 GPR156 cDNA의 위치 1534 내지 1536 (서열 번호:19 참조)에 상응하는 위치는 글루타민산 (코돈 GAA 또는 GAG를 통해)을 인코딩한다. 일부 구체예에서, 이러한 GPR156 cDNA의 위치 1534 내지 1536 (서열 번호:19 참조)에 상응하는 위치는 아스파르트산 (코돈 GAT 또는 GAC를 통해)을 인코딩한다. 일부 구체예에서, cDNA는 상기 cDNA의 위치 1587 (서열 번호:19 참조)에 상응하는 위치에서 시토신을 포함한다. 이러한 시토신은 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈의 세 번째 위치에 상응한다).
GPR156의 세포질 도메인은 GPR156의 위치 310 내지 814에 의해 인코딩된다. 일부 구체예에서, cDNA는 서열 번호:4의 위치 310 내지 814를 인코딩한다. 일부 구체예에서, 이러한 cDNA의 핵산 서열은 서열 번호:20에서 진술되는데, 여기서 위치 670 내지 672는 아스파르트산 (코돈 GAT를 통해)을 인코딩한다. 일부 구체예에서, cDNA는 서열 번호:20에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 핵산 서열을 포함하거나 또는 이것으로 구성되고, 그리고 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAT 코돈을 포함한다). 일부 구체예에서, GPR156 cDNA의 위치 619 내지 621 (서열 번호:20 참조)에 상응하는 위치는 글루타민산을 인코딩한다. 일부 구체예에서, GPR156 cDNA의 위치 619 내지 621 (서열 번호:20 참조)에 상응하는 위치는 아스파르트산을 인코딩한다. 일부 구체예에서, cDNA는 상기 cDNA의 위치 672 (서열 번호:20 참조)에 상응하는 위치에서 티민을 포함한다. 이러한 티민은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈의 세 번째 위치에 상응한다).
일부 구체예에서, 서열 번호:4의 위치 310 내지 814를 인코딩하는 cDNA의 핵산 서열은 서열 번호:21에서 진술되는데, 여기서 위치 670 내지 672는 아스파르트산 (코돈 GAC를 통해)을 인코딩한다. 일부 구체예에서, cDNA는 서열 번호:21에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 핵산 서열을 포함하거나 또는 이것으로 구성되고, 그리고 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAC 코돈을 포함한다. 일부 구체예에서, GPR156 cDNA의 위치 619 내지 621 (서열 번호:21 참조)에 상응하는 위치는 글루타민산을 인코딩한다. 일부 구체예에서, GPR156 cDNA의 위치 619 내지 621 (서열 번호:21 참조)에 상응하는 위치는 아스파르트산을 인코딩한다. 일부 구체예에서, cDNA는 상기 cDNA의 위치 672 (서열 번호:21 참조)에 상응하는 위치에서 시토신을 포함한다. 이러한 시토신은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈의 세 번째 위치에 상응한다).
일부 구체예에서, 단리된 핵산 분자는 위치 1599에 상응하는 위치에서 티민을 갖는, 본원에서 개시된 cDNA 또는 mRNA 분자 중에서 한 가지의 위치 1521 내지 1680을 포함하는 핵산 서열을 포함한다.
일부 구체예에서, cDNA 분자는 GPR156의 전체 cDNA 서열보다 적은 서열을 포함한다. 일부 구체예에서, cDNA 분자는 서열 번호:16, 서열 번호:17, 서열 번호:18, 서열 번호:19, 서열 번호:20, 또는 서열 번호:21의 최소한 약 5개, 최소한 약 8개, 최소한 약 10개, 최소한 약 12개, 최소한 약 15개, 최소한 약 20개, 최소한 약 25개, 최소한 약 30개, 최소한 약 35개, 최소한 약 40개, 최소한 약 45개, 최소한 약 50개, 최소한 약 60개, 최소한 약 70개, 최소한 약 80개, 최소한 약 90개, 최소한 약 100개, 최소한 약 200개, 최소한 약 300개, 최소한 약 400개, 최소한 약 500개, 최소한 약 600개, 최소한 약 700개, 최소한 약 800개, 최소한 약 900개, 최소한 약 1000개, 최소한 약 1100개, 최소한 약 1200개, 최소한 약 1300개, 최소한 약 1400개, 최소한 약 1500개, 최소한 약 1600개, 최소한 약 1700개, 최소한 약 1800개, 최소한 약 1900개, 최소한 약 2000개, 최소한 약 2100개, 최소한 약 2200개, 최소한 약 2300개, 또는 최소한 약 2400개의 인접한 뉴클레오티드를 포함하거나 또는 이들로 구성된다. 일부 구체예에서, cDNA 분자는 서열 번호:16, 서열 번호:17, 서열 번호:18, 서열 번호:19, 서열 번호:20, 또는 서열 번호:21의 최소한 약 1000개 내지 최소한 약 2000개의 인접한 뉴클레오티드를 포함하거나 또는 이들로 구성된다. 이점에 관하여, 더욱 긴 cDNA 분자는 더욱 짧은 것들보다 선호된다. 일부 구체예에서, cDNA 분자는 서열 번호:16, 서열 번호:17, 서열 번호:18, 서열 번호:19, 서열 번호:20, 또는 서열 번호:21의 최소한 약 15개, 최소한 약 20개, 최소한 약 25개, 최소한 약 30개, 최소한 약 35개, 최소한 약 40개, 최소한 약 45개, 최소한 약 50개, 최소한 약 60개, 최소한 약 70개, 최소한 약 80개, 최소한 약 90개, 최소한 약 100개, 최소한 약 200개, 최소한 약 300개, 최소한 약 400개, 또는 최소한 약 500개의 인접한 뉴클레오티드를 포함하거나 또는 이들로 구성된다. 이점에 관하여, 더욱 긴 cDNA 분자는 더욱 짧은 것들보다 선호된다. 일부 구체예에서, 이런 cDNA 분자는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하거나, 또는 각각 서열 번호:16 또는 서열 번호:17에 따른 위치 1599에 상응하는 위치에서 티민 또는 시스테인을 포함하는 코돈을 포함한다.
2개의 야생형 GPR156 mRNA에 대한 핵산 서열은 서열 번호:22에서 진술된다. 이들 야생형 GPR156 mRNA의 위치 1546 내지 1548 (서열 번호:22 참조)은 글루타민산 (코돈 GAA 또는 GAG을 통해) 또는 아스파르트산 (코돈 GAU 또는 GAC를 통해)을 인코딩한다. 이들 야생형 GPR156 mRNA의 위치 1597 내지 1599 (서열 번호:22 참조)는 글루타민산 (코돈 GAA 또는 GAG를 통해)을 인코딩한다.
다른 야생형 GPR156 mRNA의 핵산 서열은 서열 번호:23 (이것은 서열 번호:22의 위치 592 내지 603에 상응하는 위치에서 12개 뉴클레오티드의 결실을 내포한다)에서 진술된다. 이러한 야생형 GPR156 mRNA의 위치 1534 내지 1536 (서열 번호:23 참조)은 글루타민산 (코돈 GAA 또는 GAG을 통해) 또는 아스파르트산 (코돈 GAU 또는 GAC를 통해)을 인코딩한다. 이러한 야생형 GPR156 mRNA의 위치 1585 내지 1587 (서열 번호:23 참조)은 글루타민산 (코돈 GAA 또는 GAG를 통해)을 인코딩한다.
서열 번호:4의 위치 310 내지 814를 인코딩하는 GPR156 mRNA의 핵산 서열은 서열 번호:24에서 진술된다. 이러한 GPR156 mRNA의 위치 619 내지 621 (서열 번호:24 참조)은 글루타민산 (코돈 GAA 또는 GAG을 통해) 또는 아스파르트산 (코돈 GAU 또는 GAC를 통해)을 인코딩한다. 이러한 GPR156 mRNA의 위치 670 내지 672 (서열 번호:24 참조)는 글루타민산 (코돈 GAA 또는 GAG를 통해)을 인코딩한다.
본 발명은 또한 mRNA 분자를 제공한다. 본 발명은 인간 GPR156 단백질의 최소한 일부를 인코딩하는 핵산 서열을 포함하는 mRNA 분자를 제공하는데, 여기서 상기 일부는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다. 일부 구체예에서, mRNA 분자는 인간 GPR156 단백질의 최소한 일부를 인코딩하는 핵산 서열을 포함하는데, 여기서 상기 일부는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 포함한다.
일부 구체예에서, mRNA는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 전장 인간 GPR156 단백질을 인코딩한다. 일부 구체예에서, mRNA는 서열 번호:4에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 아미노산 서열을 갖는 폴리펩티드를 인코딩하는 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 상기 GPR156 단백질은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다.
일부 구체예에서, mRNA는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 포함하는 인간 GPR156 단백질을 인코딩한다. 일부 구체예에서, mRNA는 서열 번호:5에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 아미노산 서열을 갖는 폴리펩티드를 인코딩하는 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 상기 GPR156 단백질은 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 포함한다.
일부 구체예에서, mRNA는 서열 번호:4의 위치 310 내지 814에 상응하는 GPR156 단백질의 일부를 인코딩한다. 일부 구체예에서, mRNA는 서열 번호:4의 위치 310 내지 814에 상응하는 GPR156 단백질의 일부에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 아미노산 서열을 갖는 폴리펩티드를 인코딩하는 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 상기 폴리펩티드는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다.
일부 구체예에서, mRNA는 서열 번호:5의 위치 310 내지 814에 상응하는 GPR156 단백질의 일부를 인코딩한다. 일부 구체예에서, mRNA는 서열 번호:5의 위치 310 내지 814에 상응하는 GPR156 단백질의 일부에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 아미노산 서열을 갖는 폴리펩티드를 인코딩하는 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 상기 폴리펩티드는 서열 번호:5에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다.
일부 구체예에서, mRNA는 서열 번호:25의 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 위치 1597 내지 1599는 GAU이고, 따라서 아스파르트산을 인코딩한다. 일부 구체예에서, mRNA는 서열 번호:25에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 핵산 서열을 포함하거나 또는 이것으로 구성되고, 그리고 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAU 코돈을 포함한다). 일부 구체예에서, GPR156 mRNA의 위치 1546 내지 1548 (서열 번호:25 참조)에 상응하는 위치는 글루타민산을 인코딩한다. 일부 구체예에서, GPR156 mRNA의 위치 1546 내지 1548 (서열 번호:25 참조)에 상응하는 위치는 아스파르트산을 인코딩한다. 일부 구체예에서, mRNA는 GPR156 mRNA의 위치 1599 (서열 번호:25 참조)에 상응하는 위치에서 우라실을 포함한다. 이러한 우라실은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈의 세 번째 위치에 상응한다).
일부 구체예에서, mRNA는 서열 번호:26의 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 위치 1597 내지 1599는 GAC이고, 따라서 아스파르트산을 인코딩한다. 일부 구체예에서, mRNA는 서열 번호:26에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 핵산 서열을 포함하거나 또는 이것으로 구성되고, 그리고 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAC 코돈을 포함한다). 일부 구체예에서, GPR156 mRNA의 위치 1546 내지 1548 (서열 번호:26 참조)에 상응하는 위치는 글루타민산을 인코딩한다. 일부 구체예에서, GPR156 mRNA의 위치 1546 내지 1548 (서열 번호:26 참조)에 상응하는 위치는 아스파르트산을 인코딩한다. 일부 구체예에서, mRNA는 GPR156 mRNA의 위치 1599 (서열 번호:26 참조)에 상응하는 위치에서 시토신을 포함한다. 이러한 시토신은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈의 세 번째 위치에 상응한다).
일부 구체예에서, mRNA는 서열 번호:25의 위치 592 내지 603에 상응하는 위치에서 12개 뉴클레오티드의 결실을 내포하는 서열 번호:27의 핵산 서열을 포함하거나 또는 이것으로 구성된다. 일부 구체예에서, mRNA는 서열 번호:27에서 진술된 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 위치 1585 내지 1587은 GAU이고, 따라서 아스파르트산을 인코딩한다. 일부 구체예에서, mRNA는 서열 번호:27에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 핵산 서열을 포함하거나 또는 이것으로 구성된다 (그리고, 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAU 코돈을 포함한다). 일부 구체예에서, 이러한 GPR156 mRNA의 위치 1534 내지 1536 (서열 번호:27 참조)에 상응하는 위치는 글루타민산 (코돈 GAA 또는 GAG를 통해)을 인코딩한다. 일부 구체예에서, 이러한 GPR156 mRNA의 위치 1534 내지 1536 (서열 번호:27 참조)에 상응하는 위치는 아스파르트산 (코돈 GAU 또는 GAC를 통해)을 인코딩한다. 일부 구체예에서, mRNA는 GPR156 mRNA의 위치 1587 (서열 번호:27 참조)에 상응하는 위치에서 우라실을 포함한다. 이러한 우라실은 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈의 세 번째 위치에 상응한다).
일부 구체예에서, mRNA는 서열 번호:26의 위치 592 내지 603에 상응하는 위치에서 12개 뉴클레오티드의 결실을 내포하는 서열 번호:28의 핵산 서열을 포함하거나 또는 이것으로 구성된다. 일부 구체예에서, mRNA는 서열 번호:28에서 진술된 핵산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 위치 1585 내지 1587은 GAC이고, 따라서 아스파르트산을 인코딩한다. 일부 구체예에서, mRNA는 서열 번호:28에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 핵산 서열을 포함하거나 또는 이것으로 구성된다 (그리고, 서열 번호:5에 따른 위치 529에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAC 코돈을 포함한다). 일부 구체예에서, 이러한 GPR156 mRNA의 위치 1534 내지 1536 (서열 번호:28 참조)에 상응하는 위치는 글루타민산 (코돈 GAA 또는 GAG를 통해)을 인코딩한다. 일부 구체예에서, 이러한 GPR156 mRNA의 위치 1534 내지 1536 (서열 번호:28 참조)에 상응하는 위치는 아스파르트산 (코돈 GAU 또는 GAC를 통해)을 인코딩한다. 일부 구체예에서, mRNA는 GPR156 mRNA의 위치 1587 (서열 번호:28 참조)에 상응하는 위치에서 시토신을 포함한다. 이러한 시토신은 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈의 세 번째 위치에 상응한다).
일부 구체예에서, mRNA는 서열 번호:4의 위치 310 내지 814를 인코딩한다. 일부 구체예에서, 이러한 mRNA의 핵산 서열은 서열 번호:29에서 진술되는데, 여기서 위치 670 내지 672는 아스파르트산 (코돈 GAU를 통해)을 인코딩한다. 일부 구체예에서, mRNA는 서열 번호:29에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 핵산 서열을 포함하거나 또는 이것으로 구성되고, 그리고 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAU 코돈을 포함한다. 일부 구체예에서, GPR156 mRNA의 위치 619 내지 621 (서열 번호:29 참조)에 상응하는 위치는 글루타민산을 인코딩한다. 일부 구체예에서, GPR156 mRNA의 위치 619 내지 621 (서열 번호:29 참조)에 상응하는 위치는 아스파르트산을 인코딩한다. 일부 구체예에서, mRNA는 GPR156 mRNA의 위치 672 (서열 번호:29 참조)에 상응하는 위치에서 우라실을 포함한다. 이러한 우라실은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈의 세 번째 위치에 상응한다).
일부 구체예에서, 서열 번호:4의 위치 310 내지 814를 인코딩하는 mRNA의 핵산 서열은 서열 번호:30에서 진술되는데, 여기서 위치 670 내지 672는 아스파르트산 (코돈 GAC를 통해)을 인코딩한다. 일부 구체예에서, mRNA는 서열 번호:30에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 핵산 서열을 포함하거나 또는 이것으로 구성되고, 그리고 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GAC 코돈을 포함한다. 일부 구체예에서, GPR156 mRNA의 위치 619 내지 621 (서열 번호:30 참조)에 상응하는 위치는 글루타민산을 인코딩한다. 일부 구체예에서, GPR156 mRNA의 위치 619 내지 621 (서열 번호:30 참조)에 상응하는 위치는 아스파르트산을 인코딩한다. 일부 구체예에서, mRNA는 GPR156 mRNA의 위치 672 (서열 번호:30 참조)에 상응하는 위치에서 시토신을 포함한다. 이러한 시토신은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈의 세 번째 위치에 상응한다).
일부 구체예에서, 위치 1599에 상응하는 위치에서 우라실을 갖는, 본원에서 개시된 임의의 mRNA 분자의 위치 1521 내지 1680을 포함하는 핵산 서열을 포함하는 단리된 핵산 분자.
일부 구체예에서, 단리된 핵산 분자는 전체 GPR156 mRNA 서열보다 적은 뉴클레오티드를 포함한다. 일부 구체예에서, 단리된 핵산 분자는 서열 번호:25, 서열 번호:26, 서열 번호:27, 서열 번호:28, 서열 번호:29, 또는 서열 번호:30의 최소한 약 5개, 최소한 약 8개, 최소한 약 10개, 최소한 약 12개, 최소한 약 15개, 최소한 약 20개, 최소한 약 25개, 최소한 약 30개, 최소한 약 35개, 최소한 약 40개, 최소한 약 45개, 최소한 약 50개, 최소한 약 60개, 최소한 약 70개, 최소한 약 80개, 최소한 약 90개, 최소한 약 100개, 최소한 약 200개, 최소한 약 300개, 최소한 약 400개, 최소한 약 500개, 최소한 약 600개, 최소한 약 700개, 최소한 약 800개, 최소한 약 900개, 최소한 약 1000개, 최소한 약 1100개, 최소한 약 1200개, 최소한 약 1300개, 최소한 약 1400개, 최소한 약 1500개, 최소한 약 1600개, 최소한 약 1700개, 최소한 약 1800개, 최소한 약 1900개, 최소한 약 2000개, 최소한 약 2100개, 최소한 약 2200개, 최소한 약 2300개, 또는 최소한 약 2400개의 인접한 뉴클레오티드를 포함하거나 또는 이들로 구성된다. 일부 구체예에서, 단리된 핵산 분자는 서열 번호:25, 서열 번호:26, 서열 번호:27, 서열 번호:28, 서열 번호:29, 또는 서열 번호:30의 최소한 약 1000개 내지 최소한 약 2000개의 인접한 뉴클레오티드를 포함하거나 또는 이들로 구성된다. 이점에 관하여, 더욱 긴 mRNA 분자는 더욱 짧은 것들보다 선호된다. 일부 구체예에서, 단리된 핵산 분자는 서열 번호:25, 서열 번호:26, 서열 번호:27, 서열 번호:28, 서열 번호:29, 또는 서열 번호:30의 최소한 약 15개, 최소한 약 20개, 최소한 약 25개, 최소한 약 30개, 최소한 약 35개, 최소한 약 40개, 최소한 약 45개, 최소한 약 50개, 최소한 약 60개, 최소한 약 70개, 최소한 약 80개, 최소한 약 90개, 최소한 약 100개, 최소한 약 200개, 최소한 약 300개, 최소한 약 400개, 최소한 약 500개, 최소한 약 600개, 최소한 약 700개, 최소한 약 800개, 최소한 약 900개, 또는 최소한 약 1000개의 인접한 뉴클레오티드를 포함하거나 또는 이들로 구성된다. 이점에 관하여, 더욱 긴 mRNA 분자는 더욱 짧은 것들보다 선호된다. 일부 구체예에서, 이런 mRNA 분자는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하거나, 또는 각각 서열 번호:25 또는 서열 번호:26의 위치 1599에 상응하는 우라실 또는 시스테인을 포함하는 코돈을 포함한다.
본 발명은 또한, 변이체 GPR156 유전체 DNA (가령, 서열 번호:9, 서열 번호:10, 서열 번호:11, 또는 서열 번호:12), 변이체 GPR156 꼬마유전자, 변이체 GPR156 cDNA (가령, 서열 번호:16, 서열 번호:17, 서열 번호:18, 서열 번호:19, 서열 번호:20, 또는 서열 번호:21) 및/또는 변이체 GPR156 mRNA (가령, 서열 번호:25, 서열 번호:26, 서열 번호:27, 서열 번호:28, 서열 번호:29, 또는 서열 번호:30)에 혼성화하는 단리된 핵산 분자를 제공한다. 일부 구체예에서, 이런 단리된 핵산 분자는 최소한 약 5개, 최소한 약 8개, 최소한 약 10개, 최소한 약 11개, 최소한 약 12개, 최소한 약 13개, 최소한 약 14개, 최소한 약 15개, 최소한 약 16개, 최소한 약 17개, 최소한 약 18개, 최소한 약 19개, 최소한 약 20개, 최소한 약 21개, 최소한 약 22개, 최소한 약 23개, 최소한 약 24개, 최소한 약 25개, 최소한 약 30개, 최소한 약 35개, 최소한 약 40개, 최소한 약 45개, 최소한 약 50개, 최소한 약 55개, 최소한 약 60개, 최소한 약 65개, 최소한 약 70개, 최소한 약 75개, 최소한 약 80개, 최소한 약 85개, 최소한 약 90개, 최소한 약 95개, 최소한 약 100개, 최소한 약 200개, 최소한 약 300개, 최소한 약 400개, 최소한 약 500개, 최소한 약 600개, 최소한 약 700개, 최소한 약 800개, 최소한 약 900개, 최소한 약 1000개, 최소한 약 2000개, 최소한 약 3000개, 최소한 약 4000개, 최소한 약 5000개, 최소한 약 6000개, 최소한 약 7000개, 최소한 약 8000개, 최소한 약 9000개, 최소한 약 10000개, 최소한 약 11000개, 최소한 약 12000개, 최소한 약 13000개, 최소한 약 14000개, 최소한 약 15000개, 최소한 약 16000개, 최소한 약 17000개, 최소한 약 18000개, 최소한 약 19000개, 또는 최소한 약 20000개의 뉴클레오티드를 포함하거나 또는 이들로 구성된다. 일부 구체예에서, 단리된 핵산 분자는 최소한 15개의 뉴클레오티드를 포함하거나 또는 이들로 구성된다. 일부 구체예에서, 단리된 핵산 분자는 최소한 15개의 뉴클레오티드 내지 최소한 약 35개의 뉴클레오티드를 포함하거나 또는 이들로 구성된다. 일부 구체예에서, 이런 단리된 핵산 분자는 엄격한 조건 하에, 변이체 GPR156 유전체 DNA (가령, 서열 번호:9, 서열 번호:10, 서열 번호:11, 또는 서열 번호:12), 변이체 GPR156 꼬마유전자, 변이체 GPR156 cDNA (가령, 서열 번호:16, 서열 번호:17, 서열 번호:18, 서열 번호:19, 서열 번호:20, 또는 서열 번호:21) 및/또는 변이체 GPR156 mRNA (가령, 서열 번호:25, 서열 번호:26, 서열 번호:27, 서열 번호:28, 서열 번호:29, 또는 서열 번호:30)에 혼성화한다. 이런 핵산 분자는 예로서, 본원에서 설명되거나 또는 예시된 바와 같은 프로브로서, 프라이머로서, 또는 대립유전자-특이적 프라이머로서 이용될 수 있다.
일부 구체예에서, 단리된 핵산 분자는 변이체 GPR156 유전체 DNA (가령, 서열 번호:9, 서열 번호:10, 서열 번호:11, 또는 서열 번호:12), 변이체 GPR156 꼬마유전자, 변이체 GPR156 cDNA (가령, 서열 번호:16, 서열 번호:17, 서열 번호:18, 서열 번호:19, 서열 번호:20, 또는 서열 번호:21) 및/또는 변이체 GPR156 mRNA (가령, 서열 번호:25, 서열 번호:26, 서열 번호:27, 서열 번호:28, 서열 번호:29, 또는 서열 번호:30)에 최소한 약 70%, 최소한 약 75%, 최소한 약 80%, 최소한 약 85%, 최소한 약 90%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 최소한 약 99%, 또는 100% 동일한 핵산 분자의 최소한 약 15개의 인접한 뉴클레오티드에 혼성화한다. 일부 구체예에서, 단리된 핵산 분자는 약 15 내지 약 100개의 뉴클레오티드, 또는 약 15개 내지 약 35개의 뉴클레오티드를 포함하거나 또는 이들로 구성된다. 일부 구체예에서, 단리된 핵산 분자는 약 15 내지 약 100개의 뉴클레오티드를 포함하거나 또는 이들로 구성된다. 일부 구체예에서, 단리된 핵산 분자는 약 15 내지 약 35개의 뉴클레오티드를 포함하거나 또는 이들로 구성된다.
일부 구체예에서, 본원에서 개시된 핵산 분자, 유전체 DNA 분자, cDNA 분자, 또는 mRNA 분자 중에서 한 가지는 정제될 수 있다, 예를 들면, 최소한 약 90% 순수하다. 일부 구체예에서, 본원에서 개시된 핵산 분자, 유전체 DNA 분자, cDNA 분자, 또는 mRNA 분자 중에서 한 가지는 정제될 수 있다, 예를 들면, 최소한 약 95% 순수하다. 일부 구체예에서, 본원에서 개시된 핵산 분자, 유전체 DNA 분자, cDNA 분자, 또는 mRNA 분자 중에서 한 가지는 정제될 수 있다, 예를 들면, 최소한 약 99% 순수하다. 정제는 인간이 만든 정제 기술로 인간의 손에 의해 이루어진다.
본 발명은 또한, 본원에서 개시된 단리된 핵산 분자, 유전체 DNA 분자, cDNA 분자, 또는 mRNA 분자 중에서 한 가지의 단편을 제공한다. 일부 구체예에서, 단편은 본원에서 개시된 핵산 서열 중에서 한 가지, 또는 이의 임의의 보체의 최소한 약 5개, 최소한 약 8개, 최소한 약 10개, 최소한 약 11개, 최소한 약 12개, 최소한 약 13개, 최소한 약 14개, 최소한 약 15개, 최소한 약 16개, 최소한 약 17개, 최소한 약 18개, 최소한 약 19개, 최소한 약 20개, 최소한 약 21개, 최소한 약 22개, 최소한 약 23개, 최소한 약 24개, 최소한 약 25개, 최소한 약 30개, 최소한 약 35개, 최소한 약 40개, 최소한 약 45개, 최소한 약 50개, 최소한 약 55개, 최소한 약 60개, 최소한 약 65개, 최소한 약 70개, 최소한 약 75개, 최소한 약 80개, 최소한 약 85개, 최소한 약 90개, 최소한 약 95개, 또는 최소한 약 100개의 인접한 잔기를 포함하거나 또는 이들로 구성된다. 이점에 관하여, 더욱 긴 단편은 더욱 짧은 것들보다 선호된다. 일부 구체예에서, 단편은 최소한 약 5개, 최소한 약 8개, 최소한 약 10개, 최소한 약 11개, 최소한 약 12개, 최소한 약 13개, 최소한 약 14개, 최소한 약 15개, 최소한 약 16개, 최소한 약 17개, 최소한 약 18개, 최소한 약 19개, 최소한 약 20개, 최소한 약 21개, 최소한 약 22개, 최소한 약 23개, 최소한 약 24개, 최소한 약 25개, 최소한 약 30개, 최소한 약 35개, 최소한 약 40개, 최소한 약 45개, 또는 최소한 약 50개의 인접한 잔기를 포함하거나 또는 이들로 구성된다. 이점에 관하여, 더욱 긴 단편은 더욱 짧은 것들보다 선호된다. 일부 구체예에서, 단편은 최소한 약 20개, 최소한 약 25개, 최소한 약 30개, 또는 최소한 약 35개의 인접한 잔기를 포함하거나 또는 이들로 구성된다. 일부 구체예에서, 단편은 최소한 약 20개의 인접한 잔기를 포함하거나 또는 이들로 구성된다. 일부 구체예에서, 단편은 최소한 약 25개의 인접한 잔기를 포함하거나 또는 이들로 구성된다. 일부 구체예에서, 단편은 최소한 약 30개의 인접한 잔기를 포함하거나 또는 이들로 구성된다. 일부 구체예에서, 단편은 최소한 약 35개의 인접한 잔기를 포함하거나 또는 이들로 구성된다. 단편은 서열 번호:4에 따른 아미노산 서열을 갖는 단백질의 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하거나, 또는 서열 번호:5에 따른 아미노산 서열을 갖는 단백질의 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 핵산 분자의 일부를 포함하거나 또는 이것으로 구성되는 것으로 구상된다. 이런 단편은 예로서, 본원에서 설명되거나 또는 예시된 바와 같은 프로브로서, 프라이머로서, 또는 대립유전자-특이적 프라이머로서 이용될 수 있다.
본 발명은 또한, 프로브 및 프라이머를 제공한다. 본 발명의 프로브 또는 프라이머는 본원에서 개시된 핵산 분자 중에서 한 가지, 또는 이의 보체에 특이적으로 혼성화하는 핵산 서열을 갖는다. 일부 구체예에서, 프로브 또는 프라이머는 엄격한 조건 하에, 본원에서 개시된 핵산 분자 중에서 한 가지에 특이적으로 혼성화한다. 본 발명은 또한, 중간 정도의 조건 하에, 본원에서 개시된 핵산 분자 중에서 한 가지, 또는 이의 보체에 혼성화하는 핵산 서열을 갖는 핵산 분자를 제공한다. 본 발명에 따른 프로브 또는 프라이머는 바람직하게는, GPR156 단백질 내에서 E533D 변이를 인코딩하는 핵산 코돈, 또는 이의 보체를 포괄한다. 따라서, 바람직한 구체예에서, 본 발명은 상기에서 및 하기에서 더욱 상세하게 규정되는 대립유전자-특이적 프라이머를 제공한다.
본 발명에 따른 프로브 또는 프라이머는 GPR156 단백질 (가령, 서열 번호:4에 따른)을 인코딩하는 핵산 서열 내에서 E533D 변이 및/또는 GPR156의 동종형 (가령, 서열 번호:5에 따른)을 인코딩하는 핵산 분자 내에서 E529D 돌연변이를 검출하는데 이용될 수 있다. 가령, 본 발명에 따른 프라이머는 E533D 변이를 포함하는 GPR156 또는 이의 단편을 증폭하는데 이용될 수 있다. 본 발명에 따른 프라이머는 또한, E529D 돌연변이를 포함하는 GPR156 동종형 (가령, 서열 번호:5의 아미노산 서열을 갖는 동종형) 또는 이의 단편을 증폭하는데 이용될 수 있다. 본 발명에 따른 구현된 프라이머는 표 1에서 도시된다.
본 발명은 또한, 전술된 프라이머 중에서 한 가지를 포함하는 한 쌍의 프라이머를 제공한다. 프라이머의 이런 쌍을 이용함으로써, GPR156 내에 길이 다형성이 또한 검출될 수 있다. 가령, 한 쌍의 프라이머는 정준 GPR156 단백질 (가령, 서열 번호:4의)을 인코딩하는 핵산 분자를 GPR156 단백질의 N 말단에서 중심 영역으로 4개 아미노산을 결여하는 GPR156 동종형 (가령, 서열 번호:5의)을 인코딩하는 핵산 분자와 식별하는데 이용될 수 있다. 더욱 특정하게는, 이들 프라이머가 혼성화하는 위치가 GPR156 동종형에서 결여되는 4개 아미노산의 위치에 접하면, 정준 GRP156 단백질에 상응하는 증폭된 단편은 GPR156 동종형에 상응하는 증폭된 단편과 비교하여 더욱 길다.
본원에서 개시된 핵산 분자는 자연발생 GPR156 유전자, cDNA 또는 mRNA 전사체의 핵산 서열을 포함할 수 있거나, 또는 비자연발생 서열을 포함할 수 있다. 일부 구체예에서, 자연발생 서열은 동의 돌연변이, 또는 인코딩된 GPR156 폴리펩티드에 영향을 주지 않는 돌연변이로 인해 비자연발생 서열과 상이할 수 있다. 가령, 서열은 동의 돌연변이, 또는 인코딩된 GPR156 폴리펩티드에 영향을 주지 않는 돌연변이를 제외하고 동일할 수 있다. 동의 돌연변이 또는 치환은 생산된 아미노산 서열이 변형되지 않도록, 단백질을 코딩하는 유전자의 엑손 내에서 한 뉴클레오티드의 다른 뉴클레오티드로의 치환이다. 이것은 유전자 코드의 축중성 때문에 가능한데, 일부 아미노산은 하나 이상의 3-염기쌍 코돈에 의해 코딩된다. 동의 치환은 예로서, 코돈 최적화의 과정에서 이용된다. 본원에서 개시된 핵산 분자는 코돈 최적화될 수 있다.
개시된 핵산 분자와 상호작용할 수 있는 기능적 폴리뉴클레오티드 역시 본원에서 제공된다. 기능적 폴리뉴클레오티드는 특정한 기능을 갖는, 예를 들면, 표적 분자에 결합하는 또는 특정한 반응을 촉매작용하는 핵산 분자이다. 기능적 폴리뉴클레오티드의 실례는 안티센스 분자, 앱타머, 리보자임, 삼중 형성 분자, 그리고 외부 안내 서열을 포함하지만 이들에 한정되지 않는다. 기능적 폴리뉴클레오티드는 표적 분자에 의해 소유된 특이적 활성의 작동체, 저해제, 조절인자 및 자극기로서 작용할 수 있거나, 또는 기능적 폴리뉴클레오티드는 임의의 다른 분자와는 독립적으로 데노보 활성을 소유할 수 있다.
안티센스 분자는 정준 또는 비정준 염기 대합을 통해 표적 핵산 분자와 상호작용하도록 설계된다. 안티센스 분자 및 표적 분자의 상호작용은 예로서, RNA분해효소-H-매개된 RNA-DNA 하이브리드 분해를 통해 표적 분자의 파괴를 증진하도록 설계된다. 대안으로, 안티센스 분자는 표적 분자 상에서 정상적으로 발생할 처리 기능, 예를 들면, 전사 또는 복제를 방해하도록 설계된다. 안티센스 분자는 표적 분자의 서열에 근거하여 설계될 수 있다. 표적 분자의 가장 접근가능한 영역을 확인함으로써 안티센스 효율의 최적화를 위한 다양한 방법이 존재한다. 예시적인 방법은 시험관내 선별 실험, 그리고 DMS 및 DEPC를 이용한 DNA 변형 연구를 포함하지만 이들에 한정되지 않는다. 안티센스 분자는 일반적으로, 약 10-6보다 적거나 또는 이와 동등한, 약 10-8보다 적거나 또는 이와 동등한, 약 10-10보다 적거나 또는 이와 동등한, 또는 약 10-12보다 적거나 또는 이와 동등한 해리 상수 (kd)로 표적 분자에 결합한다. 안티센스 분자의 설계 및 이용을 보조하는 방법 및 기술의 대표적인 표본은 다음의 무제한적 U.S. 특허 목록에서 발견될 수 있다: 5,135,917; 5,294,533; 5,627,158; 5,641,754; 5,691,317; 5,780,607; 5,786,138; 5,849,903; 5,856,103; 5,919,772; 5,955,590; 5,990,088; 5,994,320; 5,998,602; 6,005,095; 6,007,995; 6,013,522; 6,017,898; 6,018,042; 6,025,198; 6,033,910; 6,040,296; 6,046,004; 6,046,319; 및 6,057,437. 안티센스 분자의 실례는 안티센스 RNAs, 짧은 간섭 RNAs (siRNAs) 및 짧은 헤어핀 RNAs (shRNAs)를 포함하지만 이들에 한정되지 않는다.
본원에서 개시된 단리된 핵산 분자는 RNA, DNA, 또는 RNA와 DNA 둘 모두를 포함할 수 있다. 단리된 핵산 분자는 또한, 예로서 벡터 또는 이종성 표지 내에 이종성 핵산 서열에 연결되거나 또는 융합될 수 있다. 가령, 본원에서 개시된 단리된 핵산 분자는 단리된 핵산 분자 및 이종성 핵산 서열을 포함하는 벡터 또는 외인성 공여자 서열 내에 있을 수 있다. 단리된 핵산 분자는 또한, 이종성 표지, 예를 들면, 형광 표지에 연결되거나 또는 융합될 수 있다. 표지의 다른 실례는 본원의 다른 곳에서 개시된다.
표지는 직접적으로 검출가능한 표지 (가령, 형광단) 또는 간접적으로 검출가능한 표지 (가령, 합텐, 효소 또는 형광단 퀀처)일 수 있다. 이런 표지는 분광, 광화학, 생화학적, 면역화학적 또는 화학적 수단에 의해 검출가능할 수 있다. 이런 표지는 예로서, 방사성-계수 장치로 계측될 수 있는 방사성 표지; 시각적으로 관찰되거나 또는 분광광도계로 계측될 수 있는 색소, 염료 또는 다른 색소원; 스핀 표지 분석기로 계측될 수 있는 스핀 표지; 그리고 형광 표지 (가령, 형광단) (여기서 출력 신호는 적합한 분자 부가물의 여기에 의해 산출된다)를 포함하고, 그리고 염료에 의해 흡수되는 광으로 여기에 의해 가시화될 수 있거나, 또는 표준 형광측정기 또는 영상화 시스템으로 계측될 수 있다. 표지는 또한, 예로서 화학발광 물질 (여기서 출력 신호는 신호 화합물의 화학적 변형에 의해 산출된다); 금속-내포 물질; 또는 효소 (여기서 신호의 효소-의존성 이차적 산출, 예를 들면, 무색 기질로부터 착색된 산물의 형성이 발생한다)일 수 있다. 용어 "표지"는 또한, 접합된 분자가 차후에 기질과 함께 첨가될 때, 검출가능한 신호를 산출하는데 이용되도록, 접합된 분자에 선별적으로 결합할 수 있는 "태그" 또는 합텐을 지칭할 수 있다. 가령, 비오틴을 태그로서 이용하고, 그리고 이후, 양고추냉이 과산화효소 (HRP)의 아비딘 또는 스트렙타비딘 접합체를 이용하여 태그에 결합하고, 그리고 이후 열량측정 기질 (가령, 테트라메틸벤지딘 (TMB)) 또는 형광원 기질을 이용하여 HRP의 존재를 검출할 수 있다. 정제를 용이하게 하기 위한 태그로서 이용될 수 있는 예시적인 표지는 myc, HA, FLAG 또는 3XFLAG, 6XHis 또는 폴리히스티딘, 글루타티온-S-전달효소 (GST), 말토오스 결합 단백질, 에피토프 태그, 또는 면역글로불린의 Fc 부분을 포함하지만 이들에 한정되지 않는다. 다양한 표지가 알려져 있고, 그리고 예로서, 입자, 형광단, 합텐, 효소, 그리고 이들의 열량측정, 형광원 및 화학발광 기질, 그리고 다른 표지를 포함한다.
개시된 핵산 분자는 예로서, 뉴클레오티드 또는 비자연 또는 변형된 뉴클레오티드, 예를 들면, 뉴클레오티드 유사체 또는 뉴클레오티드 대체재를 포함할 수 있다. 이런 뉴클레오티드는 변형된 염기, 당 또는 인산염 기를 내포하거나, 또는 구조 내에 비자연 모이어티를 통합하는 뉴클레오티드를 포함한다. 비자연 뉴클레오티드의 실례는 디데옥시뉴클레오티드, 비오틴화된, 아민화된, 탈아미노화된, 알킬화된, 벤질화된 및 형광단-표지화된 뉴클레오티드를 포함하지만 이들에 한정되지 않는다.
본원에서 개시된 핵산 분자는 또한, 하나 또는 그 이상의 뉴클레오티드 유사체 또는 치환을 포함할 수 있다. 뉴클레오티드 유사체는 염기, 당 또는 인산염 모이어티에 변형을 내포하는 뉴클레오티드이다. 염기 모이어티에 변형은 A, C, G 및 T/U의 자연 및 합성 변형뿐만 아니라 상이한 퓨린 또는 피리미딘 염기, 예를 들면, 예로서, 슈도우리딘, 우라실-5-일, 히포크산틴-9-일 (I) 및 2-아미노아데닌-9-일을 포함하지만 이들에 한정되지 않는다. 변형된 염기는 5-메틸시토신 (5-me-C), 5-히드록시메틸 시토신, 크산틴, 히포크산틴, 2-아미노아데닌, 아데닌 및 구아닌의 6-메틸 및 다른 알킬 유도체, 아데닌 및 구아닌의 2-프로필 및 다른 알킬 유도체, 2-티오우라실, 2-티오티민 및 2-티오시토신, 5-할로우라실 및 시토신, 5-프로피닐 우라실 및 시토신, 6-아조 우라실, 시토신 및 티민, 5-우라실 (슈도우라실), 4-티오우라실, 8-할로, 8-아미노, 8-티올, 8-티오알킬, 8-히드록실 및 다른 8-치환된 아데닌 및 구아닌, 5-할로, 특히 5-브로모, 5-트리플루오로메틸 및 다른 5-치환된 우라실 및 시토신, 7-메틸구아닌 및 7-메틸아데닌, 8-아자구아닌 및 8-아자아데닌, 7-데아자구아닌 및 7-데아자아데닌, 그리고 3-데아자구아닌 및 3-데아자아데닌을 포함하지만 이들에 한정되지 않는다. 2-아미노프로필아데닌, 5-프로피닐우라실, 5-프로피닐시토신 및 5-메틸시토신을 포함하지만 이들에 한정되지 않는 일정한 뉴클레오티드 유사체, 예를 들면, 예로서 5-치환된 피리미딘, 6-아자피리미딘, 그리고 N-2, N-6 및 O-6 치환된 퓨린은 이중나선 형성의 안정성을 증가시킬 수 있다. 종종, 염기 변형은 독특한 성질, 예를 들면, 증가된 이중나선 안정성을 달성하기 위해, 예로서 당 변형, 예를 들면, 2'-O-메톡시에틸과 조합될 수 있다.
뉴클레오티드 유사체는 또한, 당 모이어티의 변형을 포함할 수 있다. 당 모이어티에 대한 변형은 리보오스 및 데옥시 리보오스의 자연 변형뿐만 아니라 합성 변형을 포함하지만 이들에 한정되지 않는다. 당 변형은 2' 위치에서 다음의 변형을 포함하지만 이들에 한정되지 않는다: OH; F; O-, S- 또는 N-알킬; O-, S- 또는 N-알케닐; O-, S- 또는 N-알키닐; 또는 O-알킬-O-알킬, 여기서 알킬, 알케닐 및 알키닐은 치환되거나 또는 치환되지 않은 C1-10알킬 또는 C2-10알케닐, 그리고 C2-10알키닐일 수 있다. 예시적인 2' 당 변형은 또한, -O[(CH2)nO]mCH3, -O(CH2)nOCH3, -O(CH2)nNH2, -O(CH2)nCH3, -O(CH2)n-ONH2 및 -O(CH2)nON[(CH2)nCH3)]2를 포함하지만 이들에 한정되지 않고, 여기서 n 및 m은 1 내지 약 10이다.
2' 위치에서 다른 변형은 C1-10알킬, 치환된 저급 알킬, 알크아릴, 아르알킬, O-알크아릴 또는 O-아르알킬, SH, SCH3, OCN, Cl, Br, CN, CF3, OCF3, SOCH3, SO2CH3, ONO2, NO2, N3, NH2, 헤테로시클로알킬, 헤테로시클로알크아릴, 아미노알킬아미노, 폴리알킬아미노, 치환된 실릴, RNA 개열 기, 리포터 기, 삽입제, 올리고뉴클레오티드의 약동학적 성질을 향상시키기 위한 기, 또는 올리고뉴클레오티드의 약력학적 성질을 향상시키기 위한 기, 그리고 유사한 성질을 갖는 다른 치환체를 포함하지만 이들에 한정되지 않는다. 당 위에서 다른 위치, 특히 3' 말단 뉴클레오티드 상에서 또는 2'-5' 연결된 올리고뉴클레오티드 내에서 당의 3' 위치에서 및 5' 말단 뉴클레오티드의 5' 위치에서 또한 유사한 변형이 만들어질 수 있다. 변형된 당은 또한, 가교화 고리 산소에서 변형, 예를 들면, CH2 및 S를 내포하는 것들을 포함할 수 있다. 뉴클레오티드 당 유사체는 또한, 펜토푸라노실 당 대신에 당 모방체, 예를 들면, 시클로부틸 모이어티를 가질 수 있다.
뉴클레오티드 유사체는 또한, 인산염 모이어티에서 변형될 수 있다. 변형된 인산염 모이어티는 2개의 뉴클레오티드 사이에 연쇄가 포스포로티오에이트, 키랄 포스포로티오에이트, 포스포로디티오에이트, 포스포트리에스테르, 아미노알킬포스포트리에스테르, 3'-알킬렌 포스포네이트 및 키랄 포스포네이트를 비롯한 메틸 및 다른 알킬 포스포네이트, 포스피네이트, 3'-아미노 포스포라미데이트 및 아미노알킬포스포라미데이트를 비롯한 포스포라미데이트, 티오노포스포라미데이트, 티오노알킬포스포네이트, 티오노알킬포스포트리에스테르 및 보라노포스페이트를 내포하도록, 변형될 수 있는 것들을 포함하지만 이들에 한정되지 않는다. 2개의 뉴클레오티드 사이에 이들 인산염 또는 변형된 인산염 연쇄는 3'-5' 연쇄 또는 2'-5' 연쇄를 통해 이루어질 수 있고, 그리고 연쇄는 반전된 극성, 예를 들면, 3'- 5'에서 5'-3' 또는 2'- 5'에서 5'-2'를 내포할 수 있다. 다양한 염, 혼합된 염 및 유리 산 형태 또한 포함된다.
뉴클레오티드 대체재는 뉴클레오티드와 유사한 기능적 성질을 갖지만 인산염 모이어티를 내포하지 않는 분자, 예를 들면, 펩티드 핵산 (PNA)을 포함한다. 뉴클레오티드 대체재는 핵산을 왓슨 크릭 또는 후그스탄형 방식으로 인식할 것이지만 인산염 모이어티 이외의 모이어티를 통해 함께 연결되는 분자를 포함한다. 뉴클레오티드 대체재는 적절한 표적 핵산과 상호작용할 때 이중 나선 유형 구조에 합치할 수 있다.
뉴클레오티드 대체재는 또한, 인산염 모이어티 또는 당 모이어티가 대체된 뉴클레오티드 또는 뉴클레오티드 유사체를 포함한다. 일부 구체예에서, 뉴클레오티드 대체재는 표준 인 원자를 내포할 수 없다. 인산염에 대한 대체재는 예로서, 짧은 사슬 알킬 또는 시클로알킬 뉴클레오시드간 연쇄, 혼합된 헤테로원자 및 알킬 또는 시클로알킬 뉴클레오시드간 연쇄, 또는 하나 또는 그 이상의 짧은 사슬 헤테로원자 또는 헤테로환상 뉴클레오시드간 연쇄일 수 있다. 이들은 모르폴리노 연쇄 (뉴클레오시드의 당 부분으로부터 부분적으로 형성된); 실록산 중추; 황화물, 술폭시드 및 술폰 중추; 포름아세틸 및 티오포름아세틸 중추; 메틸렌 포름아세틸 및 티오포름아세틸 중추; 알켄 내포 중추; 술파민산염 중추; 메틸렌이미노 및 메틸렌히드라지노 중추; 술폰산염 및 술폰아미드 중추; 아미드 중추; 그리고 혼합된 N, O, S 및 CH2 성분 부분을 갖는 것들을 포함한다.
뉴클레오티드 대체재에서, 상기 뉴클레오티드의 당 및 인산염 모이어티 둘 모두 예로서, 아미드 유형 연쇄 (아미노에틸글리신) (PNA)에 의해 대체될 수 있는 것으로 또한 이해된다.
예로서, 세포 흡수를 증강하기 위해, 다른 유형의 분자 (접합체)를 뉴클레오티드 또는 뉴클레오티드 유사체에 연결하는 것도 가능하다. 접합체는 뉴클레오티드 또는 뉴클레오티드 유사체에 화학적으로 연결될 수 있다. 이런 접합체는 예로서, 지질 모이어티, 예를 들면, 콜레스테롤 모이어티, 담즙산, 티오에테르, 예를 들면, 헥실-S-트리틸티올, 티오콜레스테롤, 지방족 사슬, 예를 들면, 도데칸디올 또는 운데실 잔기, 인지질, 예를 들면, 디-헥사데실-rac-글리세롤 또는 트리에틸암모늄 1,2-디-O-헥사데실-rac-글리세로-3-H-포스포네이트, 폴리아민 또는 폴리에틸렌 글리콜 사슬, 아다만탄 아세트산, 팔미틸 모이어티, 또는 옥타데실아민 또는 헥실아미노-카르보닐-옥시콜레스테롤 모이어티를 포함한다.
본 발명은 또한, 본원에서 개시된 핵산 분자 중에서 한 가지 또는 그 이상을 포함하는 벡터를 제공한다. 일부 구체예에서, 벡터는 본원에서 개시된 핵산 분자 중에서 한 가지 또는 그 이상 및 이종성 핵산을 포함한다. 벡터는 핵산 분자를 수송할 수 있는 바이러스 또는 비바이러스 벡터일 수 있다. 일부 구체예에서, 벡터는 플라스미드 또는 코스미드 (가령, 추가 DNA 분절이 결찰될 수 있는 환상 이중 가닥 DNA)이다. 일부 구체예에서, 벡터는 바이러스 벡터인데, 여기서 추가 DNA 분절이 바이러스 유전체 내로 결찰될 수 있다. 일부 구체예에서, 벡터는 자신이 도입되는 숙주 세포에서 자율적으로 복제할 수 있다 (가령, 세균 복제 기점을 갖는 세균 벡터 및 에피솜 포유류 벡터). 일부 구체예에서, 벡터 (가령, 비-에피솜 포유류 벡터)는 숙주 세포 내로 도입 시에 숙주 세포의 유전체 내로 통합될 수 있고, 그리고 따라서, 숙주 유전체와 함께 복제된다. 게다가, 특정 벡터는 그들이 작동가능하게 연결되는 유전자의 발현을 주도할 수 있다. 이런 벡터는 본원에서, "재조합 발현 벡터" 또는 "발현 벡터"로서 지칭된다. 이런 벡터는 또한, 표적화 벡터 (다시 말하면, 외인성 공여자 서열)일 수 있다.
일부 구체예에서, 본원에서 개시된 다양한 유전자 변이체에 의해 인코딩된 단백질은 이들 유전자가 발현 제어 서열, 예를 들면, 전사와 번역 제어 서열에 작동가능하게 연결되도록, 개시된 유전자 변이체를 인코딩하는 핵산 분자를 발현 벡터 내로 삽입함으로써 발현된다. 발현 벡터는 플라스미드, 코스미드, 레트로바이러스, 아데노바이러스, 아데노 연관된 바이러스 (AAV), 식물 바이러스, 예를 들면, 콜리플라워 모자이크 바이러스 및 담배 모자이크 바이러스, 효모 인공 염색체 (YACs), 엡스타인 바르 (EBV)-유래된 에피솜, 그리고 당해 분야에서 공지된 다른 발현 벡터를 포함하지만 이들에 한정되지 않는다. 일부 구체예에서, 개시된 유전자 변이체를 포함하는 핵산 분자는 벡터 내에 전사와 번역 제어 서열이 유전자 변이체의 전사와 번역을 조절하는 그들의 의도된 기능을 제공하도록, 벡터 내로 결찰될 수 있다. 발현 벡터 및 발현 제어 서열은 이용된 발현 숙주 세포와 양립하도록 선택된다. 개시된 유전자 변이체를 포함하는 핵산 서열은 별개의 벡터 내로 또는 변이체 유전 정보와 동일한 발현 벡터 내로 삽입될 수 있다. 개시된 유전자 변이체를 포함하는 핵산 서열은 표준 방법 (가령, 개시된 유전자 변이체 및 벡터를 포함하는 핵산 상에서 상보성 제한 부위의 결찰, 또는 제한 부위가 존재하지 않으면 평활 말단 결찰)에 의해 발현 벡터 내로 삽입될 수 있다.
개시된 유전자 변이체를 포함하는 핵산 서열에 더하여, 재조합 발현 벡터는 숙주 세포에서 유전자 변이체의 발현을 제어하는 조절 서열을 보유할 수 있다. 조절 서열의 선별을 비롯하여, 발현 벡터의 설계는 형질전환되는 숙주 세포의 선택, 원하는 단백질의 발현 수준 등과 같은 인자에 의존할 수 있다. 포유류 숙주 세포 발현을 위한 바람직한 조절 서열은 예로서, 포유류 세포에서 높은 수준의 단백질 발현을 주동하는 바이러스 요소, 예를 들면, 레트로바이러스 LTRs, 시토메갈로바이러스 (CMV) (가령, CMV 프로모터/인핸서), 유인원 바이러스 40 (SV40) (가령, SV40 프로모터/인핸서), 아데노바이러스 (가령, 아데노바이러스 주요 후기 프로모터 (AdMLP)), 폴리오마 및 강한 포유류 프로모터, 예를 들면, 선천적 면역글로불린 및 액틴 프로모터로부터 유래된 프로모터 및/또는 인핸서를 포함할 수 있다. 폴리펩티드를 세균 세포 또는 진균 세포 (가령, 효모 세포)에서 발현하는 방법 역시 널리 공지된다.
프로모터는 예로서, 구조성으로 활성 프로모터, 조건적 프로모터, 유도성 프로모터, 시간적으로 제한된 프로모터 (가령, 발달적으로 조절된 프로모터), 또는 공간적으로 제한된 프로모터 (가령, 세포 특이적 또는 조직 특이적 프로모터)일 수 있다. 프로모터의 실례는 가령, WO 2013/176772에서 발견될 수 있다.
유도성 프로모터의 실례는 예로서, 화학적으로 조절된 프로모터 및 물리적으로 조절된 프로모터를 포함한다. 화학적으로 조절된 프로모터는 예로서, 알코올-조절된 프로모터 (가령, 알코올 탈수소효소 (alcA) 유전자 프로모터), 테트라사이클린-조절된 프로모터 (가령, 테트라사이클린-반응성 프로모터, 테트라사이클린 오퍼레이터 서열 (tetO), tet-온 프로모터, 또는 tet-오프 프로모터), 스테로이드 조절된 프로모터 (가령, 쥐 글루코코르티코이드 수용체, 에스트로겐 수용체의 프로모터, 또는 엑디손 수용체의 프로모터), 또는 금속-조절된 프로모터 (가령, 금속단백질 프로모터)를 포함한다. 물리적으로 조절된 프로모터는 예로서, 온도-조절된 프로모터 (가령, 열 충격 프로모터) 및 광-조절된 프로모터 (가령, 광유도성 프로모터 또는 광-억제성 프로모터)를 포함한다.
조직 특이적 프로모터는 예로서, 뉴런-특이적 프로모터, 아교세포-특이적 프로모터, 근육 세포 특이적 프로모터, 심장 세포 특이적 프로모터, 신장 세포 특이적 프로모터, 뼈 세포 특이적 프로모터, 내피 세포-특이적 프로모터, 또는 면역 세포-특이적 프로모터 (가령, B 세포 프로모터 또는 T 세포 프로모터)일 수 있다.
발달적으로 조절된 프로모터는 예로서, 발달의 배아 시기 동안에만, 또는 성체 세포에서만 활성인 프로모터를 포함한다.
개시된 유전자 변이체 및 조절 서열을 포함하는 핵산 서열에 더하여, 재조합 발현 벡터는 추가 서열, 예를 들면, 숙주 세포에서 벡터의 복제를 조절하는 서열 (가령, 복제 기점) 및 선별가능 마커 유전자를 보유할 수 있다. 선별가능 마커 유전자는 벡터가 도입된 숙주 세포의 선별을 용이하게 할 수 있다 (가령, U.S. 특허 4,399,216; 4,634,665; 및 5,179,017을 참조한다). 가령, 선별가능 마커 유전자는 벡터가 도입된 숙주 세포에서 약물, 예를 들면, G418, 히그로마이신 또는 메토트렉사트에 대한 내성을 부여할 수 있다. 예시적인 선별가능 마커 유전자는 디히드로폴레이트 환원효소 (DHFR) 유전자 (메토트렉사트 선별/증폭을 갖는 dhfr-숙주 세포에서 이용을 위한), neo 유전자 (G418 선별을 위한), 그리고 글루타민산염 합성효소 (GS) 유전자를 포함하지만 이들에 한정되지 않는다.
추가 벡터는 예로서, 2016년 7월 28일자 제출된 U.S. 가출원 번호 62/367,973에서 설명되는데, 이것은 본원에서 전체적으로 참조로서 편입된다.
본 발명은 또한, 본원에서 개시된 단리된 핵산 분자, 유전체 DNA 분자, cDNA 분자, 또는 mRNA 분자 중에서 한 가지 또는 그 이상을 포함하는 조성물을 제공한다. 일부 구체예에서, 조성물은 제약학적 조성물이다.
본 발명은 또한, 변이체 GPR156 폴리펩티드를 제공한다. 본 발명은 GPR156 단백질의 최소한 일부를 포함하는 단리된 또는 재조합 폴리펩티드를 제공하는데, 여기서 상기 일부는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함한다. 일부 구체예에서, 단리된 또는 재조합 폴리펩티드는 GPR156 단백질의 최소한 일부를 포함하는데, 여기서 상기 일부는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 포함한다.
일부 구체예에서, 단리된 또는 재조합 폴리펩티드는 서열 번호:4에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 아미노산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 상기 폴리펩티드의 위치 533 (서열 번호:4에 따른)에 상응하는 위치에서 아미노산은 아스파르트산이다. 일부 구체예에서, 폴리펩티드는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 전장 GPR156 단백질을 포함한다. 일부 구체예에서, 전장 GPR156 단백질은 서열 번호:4에 최소한 약 90%, 약 91%, 약 92%, 약 93%, 약 94%, 약 95%, 약 96%, 약 97%, 약 98%, 또는 약 99% 서열 동일성을 갖는 아미노산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 상기 폴리펩티드의 위치 533 (서열 번호:4에 따른)에 상응하는 위치에서 아미노산은 아스파르트산이다. 일부 구체예에서, 폴리펩티드는 서열 번호:4의 아미노산 서열을 포함한다. 일부 구체예에서, 폴리펩티드는 서열 번호:4의 아미노산 서열로 구성된다. 이러한 변이체 GPR156 단백질의 위치 516 (서열 번호:4 참조)에 상응하는 위치는 글루타민산 또는 아스파르트산이다. 일부 구체예에서, 이러한 변이체 GPR156 단백질의 위치 516 (서열 번호:4 참조)에 상응하는 위치는 글루타민산이다. 일부 구체예에서, 이러한 변이체 GPR156 단백질의 위치 516 (서열 번호:4 참조)에 상응하는 위치는 아스파르트산이다.
일부 구체예에서, 단리된 또는 재조합 폴리펩티드는 서열 번호:5에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 아미노산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 상기 폴리펩티드의 위치 529 (서열 번호:5에 따른)에 상응하는 위치에서 아미노산은 아스파르트산이다. 일부 구체예에서, 폴리펩티드는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 포함하는 GPR156 단백질을 포함한다. 일부 구체예에서, GPR156 단백질은 서열 번호:5에 최소한 약 90%, 약 91%, 약 92%, 약 93%, 약 94%, 약 95%, 약 96%, 약 97%, 약 98%, 또는 약 99% 서열 동일성을 갖는 아미노산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 상기 폴리펩티드의 위치 529 (서열 번호:5에 따른)에 상응하는 위치에서 아미노산은 아스파르트산이다. 일부 구체예에서, 폴리펩티드는 서열 번호:5의 아미노산 서열을 포함한다. 일부 구체예에서, 폴리펩티드는 서열 번호:5의 아미노산 서열로 구성된다. 이러한 변이체 GPR156 단백질의 위치 512 (서열 번호:5 참조)에 상응하는 위치는 글루타민산 또는 아스파르트산이다. 일부 구체예에서, 이러한 변이체 GPR156 단백질의 위치 512 (서열 번호:5 참조)에 상응하는 위치는 글루타민산이다. 일부 구체예에서, 이러한 변이체 GPR156 단백질의 위치 512 (서열 번호:5 참조)에 상응하는 위치는 아스파르트산이다.
일부 구체예에서, 폴리펩티드는 서열 번호:4의 위치 310 내지 814에 상응하는 GPR156 단백질의 일부를 포함한다. 일부 구체예에서, 폴리펩티드는 서열 번호:4의 위치 310 내지 814에 최소한 약 90%, 최소한 약 91%, 최소한 약 92%, 최소한 약 93%, 최소한 약 94%, 최소한 약 95%, 최소한 약 96%, 최소한 약 97%, 최소한 약 98%, 또는 최소한 약 99% 서열 동일성을 갖는 아미노산 서열을 포함하거나 또는 이것으로 구성되는데, 여기서 서열 번호:4에 따른 위치 533에 상응하는 위치 (가령, 위치 224)에서 아미노산은 아스파르트산이다. 일부 구체예에서, 폴리펩티드는 서열 번호:6의 아미노산 서열을 포함한다. 일부 구체예에서, 폴리펩티드는 서열 번호:6의 아미노산 서열로 구성된다. 이러한 GPR156 단백질의 위치 207 (서열 번호:6 참조)에 상응하는 위치는 글루타민산 또는 아스파르트산이다. 일부 구체예에서, 이러한 GPR156 단백질의 위치 207 (서열 번호:6 참조)에 상응하는 위치는 글루타민산이다. 일부 구체예에서, 이러한 GPR156 단백질의 위치 207 (서열 번호:6 참조)에 상응하는 위치는 아스파르트산이다.
본 발명은 또한, 본원에서 개시된 폴리펩티드 중에서 한 가지의 단편을 제공한다. 일부 구체예에서, 단편은 인코딩된 폴리펩티드의 최소한 약 10개, 최소한 약 15개, 최소한 약 20개, 최소한 약 25개, 최소한 약 30개, 최소한 약 35개, 최소한 약 40개, 최소한 약 45개, 최소한 약 50개, 최소한 약 55개, 최소한 약 60개, 최소한 약 65개, 최소한 약 70개, 최소한 약 75개, 최소한 약 80개, 최소한 약 85개, 최소한 약 90개, 최소한 약 95개, 최소한 약 100개, 최소한 약 150개, 최소한 약 200개, 최소한 약 250개, 최소한 약 300개, 최소한 약 350개, 최소한 약 400개, 최소한 약 450개, 최소한 약 500개, 최소한 약 550개, 최소한 약 600개, 최소한 약 650개, 최소한 약 700개, 최소한 약 750개, 또는 최소한 약 800개의 인접한 아미노산 잔기를 포함한다. 이점에 관하여, 더욱 긴 단편은 더욱 짧은 것들보다 선호된다. 일부 구체예에서, 단편은 인코딩된 폴리펩티드의 최소한 약 10개, 최소한 약 15개, 최소한 약 20개, 최소한 약 25개, 최소한 약 30개, 최소한 약 35개, 최소한 약 40개, 최소한 약 45개, 최소한 약 50개, 최소한 약 55개, 최소한 약 60개, 최소한 약 65개, 최소한 약 70개, 최소한 약 75개, 최소한 약 80개, 최소한 약 85개, 최소한 약 90개, 최소한 약 95개, 또는 최소한 약 100개의 인접한 아미노산 잔기를 포함한다. 이점에 관하여, 더욱 긴 단편은 더욱 짧은 것들보다 선호된다.
본 발명은 또한, 변이체 GPR156을 포함하는 단리된 폴리펩티드를 포함하는 이합체를 제공하고, 여기서 상기 폴리펩티드는 본원에서 개시된 폴리펩티드 중에서 한 가지에서 선택된다.
일부 구체예에서, 본원에서 개시된 단리된 폴리펩티드는 이종성 폴리펩티드, 또는 이종성 분자 또는 표지에 연결되거나 또는 융합되는데, 이들의 다양한 실례는 본원의 다른 곳에서 개시된다. 가령, 이들 단백질은 증가된 또는 감소된 안정성을 제공하는 이종성 폴리펩티드에 융합될 수 있다. 융합된 도메인 또는 이종성 폴리펩티드는 N 말단에서, C 말단에서, 또는 폴리펩티드 내에 내적으로 위치될 수 있다. 융합 상대는 예로서, T 보조 에피토프를 제공하는 것을 보조할 수 있거나 (면역학적 융합 상대), 또는 선천적 재조합 폴리펩티드보다 더욱 높은 수율에서 단백질을 발현하는 것을 보조할 수 있다 (발현 인핸서). 일정한 융합 상대는 면역학적 융합 상대 및 발현 증강 융합 상대 둘 모두이다. 다른 융합 상대는 폴리펩티드의 용해도를 증가시키거나, 또는 원하는 세포내 구획으로 폴리펩티드의 표적화를 용이하게 하도록 선별될 수 있다. 일부 융합 상대는 친화성 태그를 포함하는데, 이들은 폴리펩티드의 정제를 용이하게 한다.
일부 구체예에서, 융합 단백질은 이종성 분자에 직접적으로 융합되거나, 또는 링커, 예를 들면, 펩티드 링커를 거쳐 이종성 분자에 연결된다. 적합한 펩티드 링커 서열은 예로서, 다음의 인자에 근거하여 선택될 수 있다: 1) 유연한 확장된 입체형태를 채택하는 능력; 2) 첫 번째와 두 번째 폴리펩티드 상에서 기능적 에피토프와 상호작용할 수 있었던 이차 구조를 채택하는 것에 대한 저항; 및 3) 폴리펩티드 기능적 에피토프와 반응할지도 모르는 소수성 또는 하전된 잔기의 결여. 가령, 펩티드 링커 서열은 Gly, Asn 및 Ser 잔기를 내포할 수 있다. 다른 거의 중성 아미노산, 예를 들면, Thr 및 Ala 역시 링커 서열에서 이용될 수 있다. 링커로서 유용하게 이용될 수 있는 아미노산 서열은 예로서, Maratea et al., Gene, 1985, 40, 39-46; Murphy et al., Proc. Natl. Acad. Sci. USA, 1986, 83, 8258-8262; 그리고 U.S. 특허 4,935,233 및 4,751,180에서 개시된 것들을 포함한다. 링커 서열은 일반적으로, 길이에서 예로서, 1 내지 약 50개 아미노산일 수 있다. 첫 번째와 두 번째 폴리펩티드가 기능적 도메인을 분리하고 입체 장애를 예방하는데 이용될 수 있는 비필수적인 N 말단 아미노산 영역을 가질 때, 링커 서열은 일반적으로 필요하지 않다.
일부 구체예에서, 폴리펩티드는 세포-투과성 도메인에 작동가능하게 연결된다. 가령, 세포-투과성 도메인은 HIV-1 TAT 단백질, 인간 B형 간염 바이러스로부터 TLM 세포-투과성 모티프, MPG, Pep-1, VP22, 단순 헤르페스 바이러스로부터 세포-투과성 펩티드, 또는 폴리아르기닌 펩티드 서열로부터 유래될 수 있다. 가령, WO 2014/089290을 참조한다. 세포-투과성 도메인은 N 말단에서, C 말단에서, 또는 단백질 내에 어디든지 위치될 수 있다.
일부 구체예에서, 폴리펩티드는 추적 또는 정제의 편의성을 위해 이종성 폴리펩티드, 예를 들면, 형광 단백질, 정제 태그, 또는 에피토프 태그에 작동가능하게 연결된다. 형광 단백질의 실례는 녹색 형광 단백질 (가령, GFP, GFP-2, tagGFP, turboGFP, eGFP, Emerald, Azami Green, 단위체성 Azami Green, CopGFP, AceGFP, ZsGreenl), 황색 형광 단백질 (가령, YFP, eYFP, Citrine, Venus, YPet, PhiYFP, ZsYellowl), 청색 형광 단백질 (가령, eBFP, eBFP2, Azurite, mKalamal, GFPuv, Sapphire, T-sapphire), 시안색 형광 단백질 (가령, eCFP, Cerulean, CyPet, AmCyanl, Midoriishi-Cyan), 적색 형광 단백질 (가령, mKate, mKate2, mPlum, DsRed 단위체, mCherry, mRFP1, DsRed-Express, DsRed2, DsRed-단위체, HcRed-탠덤, HcRedl, AsRed2, eqFP611, mRaspberry, mStrawberry, Jred), 오렌지색 형광 단백질 (가령, mOrange, mKO, Kusabira-Orange, 단위체성 Kusabira-Orange, mTangerine, tdTomato), 그리고 임의의 다른 적합한 형광 단백질을 포함하지만 이들에 한정되지 않는다. 태그의 실례는 글루타티온-S-전달효소 (GST), 키틴 결합 단백질 (CBP), 말토오스 결합 단백질, 티오레독신 (TRX), 폴리(NANP), 탠덤 친화성 정제 (TAP) 태그, myc, AcV5, AU1, AU5, E, ECS, E2, FLAG, 적혈구응집소 (HA), nus, Softag 1, Softag 3, Strep, SBP, Glu-Glu, HSV, KT3, S, S1, T7, V5, VSV-G, 히스티딘 (His), 비오틴 카르복실 운반 단백질 (BCCP), 그리고 칼모듈린을 포함하지만 이들에 한정되지 않는다. 일부 구체예에서, 이종성 분자는 면역글로불린 Fc 도메인, 펩티드 태그, 형질도입 도메인, 폴리(에틸렌 글리콜), 폴리시알산, 또는 글리콜산이다.
일부 구체예에서, 단리된 폴리펩티드는 비자연 또는 변형된 아미노산 또는 펩티드 유사체를 포함한다. 가령, 다양한 D-아미노산, 또는 자연발생 아미노산과 상이한 기능적 치환체를 갖는 아미노산이 있다. 자연발생 펩티드의 반대 입체이성질체뿐만 아니라 펩티드 유사체의 입체이성질체가 개시된다. 이들 아미노산은 tRNA 분자를 선택되는 아미노산으로 채우고, 그리고 유사체 아미노산을 펩티드 사슬 내로 부위 특이적 방식으로 삽입하기 위해 예로서, 앰버 코돈을 활용하는 유전자 구조체를 가공함으로써 폴리펩티드 사슬 내로 쉽게 통합될 수 있다.
일부 구체예에서, 단리된 폴리펩티드는 펩티드 모방체인데, 이들은 펩티드와 유사하도록 생산될 수 있지만 자연 펩티드 결합을 통해 연결되지 않는다. 가령, 아미노산 또는 아미노산 유사체에 대한 연쇄는 -CH2NH-, -CH2S-, -CH2-, -CH=CH- (시스 및 트랜스), -COCH2-, -CH(OH)CH2- 및 -CHH2SO-를 포함하지만 이들에 한정되지 않는다. 펩티드 유사체는 결합 원자 사이에 하나 이상의 원자, 예를 들면 b-알라닌, g아미노부티르산 등을 가질 수 있다. 아미노산 유사체 및 펩티드 유사체는 종종, 증강된 또는 바람직한 성질, 예를 들면, 더욱 경제적인 생산, 더욱 큰 화학적 안정성, 증강된 약리학적 성질 (반감기, 흡수, 효능, 효력 등), 변경된 특이성 (가령, 광역의 생물학적 활성), 감소된 항원성, 그리고 기타 바람직한 성질을 갖는다.
일부 구체예에서, 단리된 폴리펩티드는 D-아미노산을 포함하는데, 이들 D 아미노산은 펩티드분해효소에 의해 인식되지 않기 때문에, 더욱 안정된 펩티드를 산출하는데 이용될 수 있다. 동일한 유형의 D-아미노산으로 공통 서열의 하나 또는 그 이상의 아미노산의 체계적인 치환 (가령, L-리신 대신에 D-리신)은 더욱 안정된 펩티드를 산출하는데 이용될 수 있다. 시스테인 잔기는 2개 또는 그 이상의 펩티드를 환화하거나 또는 이들을 함께 부착하는데 이용될 수 있다. 이것은 펩티드를 특정 입체형태로 제약하는데 유익할 수 있다 (가령, Rizo and Gierasch, Ann. Rev. Biochem., 1992, 61, 387을 참조한다).
본 발명은 또한, 본원에서 개시된 폴리펩티드 중에서 한 가지를 인코딩하는 핵산 분자를 제공한다. 이것은 특정한 폴리펩티드 서열에 관련된 모든 축중성 서열 (하나의 특정 폴리펩티드 서열을 인코딩하는 서열을 갖는 모든 핵산뿐만 아니라 단백질 서열의 개시된 변이체와 유도체를 인코딩하는, 축중성 핵산을 비롯한 모든 핵산)을 포함한다. 따라서, 각 특정 핵산 서열이 본원에서 정서되지 않을 수도 있지만, 각각의 모든 서열은 개시된 폴리펩티드 서열을 통해 본원에서 실제로 개시되고 설명된다.
핵산 내에 핵산 서열 또는 폴리펩티드 내에 아미노산 서열의 특정 스트레치 사이에 동일성 퍼센트 (또는 상보성 퍼센트)는 BLAST 프로그램 (기본 국부 정렬 검색 도구) 및 PowerBLAST 프로그램 (Altschul et al., J. Mol. Biol., 1990, 215, 403-410; Zhang and Madden, Genome Res., 1997, 7, 649-656)을 이용하거나, 또는 Smith 및 Waterman (Adv. Appl. Math., 1981, 2, 482-489)의 알고리즘을 이용하는, 디폴트 세팅의 Gap 프로그램 (Wisconsin Sequence Analysis Package, Unix용 Version 8, Genetics Computer Group, University Research Park, Madison Wis.)을 이용함으로써 일과적으로 결정될 수 있다. 본원에서, 서열 동일성 퍼센트가 언급되면, 서열 동일성의 더욱 높은 백분율은 더욱 낮은 백분율보다 선호된다.
본 발명은 또한, 본원에서 개시된 핵산 분자 중에서 한 가지 또는 그 이상 및/또는 본원에서 개시된 폴리펩티드 중에서 한 가지 또는 그 이상 및 담체 및/또는 부형제를 포함하는 조성물을 제공한다. 일부 구체예에서, 담체는 핵산 분자 및/또는 폴리펩티드의 안정성을 증가시킨다 (가령, 분해 산물이 역치 미만, 예를 들면, 시작 핵산 또는 단백질의 중량으로 0.5% 미만으로 남아있는 소정의 저장 조건 (가령, -20℃, 4℃, 또는 주위 온도) 하에 기간을 연장하거나; 또는 생체내 안정성을 증가시킨다). 담체의 실례는 폴리(유산) (PLA) 마이크로스피어, 폴리(D,L-유산-코글리콜산) (PLGA) 마이크로스피어, 리포솜, 미셀, 역 미셀, 지질 카클리어트, 그리고 지질 미소관을 포함하지만 이들에 한정되지 않는다. 담체는 완충된 염 용액, 예를 들면, PBS, HBSS 등을 포함할 수 있다.
본 발명은 또한, 본원에서 개시된 폴리펩티드 또는 이들의 단편 중에서 한 가지를 생산하는 방법을 제공한다. 이런 폴리펩티드 또는 이들의 단편은 임의의 적합한 방법에 의해 생산될 수 있다. 가령, 폴리펩티드 또는 이들의 단편은 이런 폴리펩티드 또는 이들의 단편을 인코딩하는 핵산 분자 (가령, 재조합 발현 벡터)를 포함하는 숙주 세포로부터 생산될 수 있다. 이런 방법은 폴리펩티드 또는 이의 단편을 생산하는데 충분한 조건 하에 상기 폴리펩티드 또는 이의 단편을 인코딩하는 핵산 분자 (가령, 재조합 발현 벡터)를 포함하는 숙주 세포를 배양하고, 따라서 상기 폴리펩티드 또는 이의 단편을 생산하는 것을 포함할 수 있다. 핵산은 숙주 세포에서 활성인 프로모터에 작동가능하게 연결될 수 있고, 그리고 배양하는 것은 상기 핵산이 발현되는 조건 하에 실행될 수 있다. 이런 방법은 발현된 폴리펩티드 또는 이의 단편을 회수하는 것을 더욱 포함할 수 있다. 회수하는 것은 폴리펩티드 또는 이의 단편을 정제하는 것을 더욱 포함할 수 있다.
단백질 발현을 위한 적합한 시스템의 실례는 숙주 세포, 예를 들면, 예로서: 세균 세포 발현 시스템 (가령, 대장균 (Escherichia coli), 락토코쿠스 락티스 (Lactococcus lactis)), 효모 세포 발현 시스템 (가령, 사카로미세스 세레비시에 (Saccharomyces cerevisiae), 피치아 파스토리스 (Pichia pastoris)), 곤충 세포 발현 시스템 (가령, 배큘로바이러스-매개된 단백질 발현), 그리고 포유류 세포 발현 시스템을 포함한다.
폴리펩티드 또는 이들의 단편을 인코딩하는 핵산 분자의 실례는 본원의 다른 곳에서 더욱 상세하게 개시된다. 일부 구체예에서, 핵산 분자는 숙주 세포에서 발현을 위해 코돈 최적화된다. 일부 구체예에서, 핵산 분자는 숙주 세포에서 활성인 프로모터에 작동가능하게 연결된다. 프로모터는 이종성 프로모터 (가령, 자연발생 프로모터가 아닌 프로모터)일 수 있다. 대장균 (Escherichia coli)에 적합한 프로모터의 실례는 아라비노오스, lac, tac 및 T7 프로모터를 포함하지만 이들에 한정되지 않는다. 락토코쿠스 락티스 (Lactococcus lactis)에 적합한 프로모터의 실례는 P170 및 니신 프로모터를 포함하지만 이들에 한정되지 않는다. 사카로미세스 세레비시에 (Saccharomyces cerevisiae)에 적합한 프로모터의 실례는 구조성 프로모터, 예를 들면, 알코올 탈수소효소 (ADHI) 또는 에놀라아제 (ENO) 프로모터, 또는 유도성 프로모터, 예를 들면, PHO, CUP1, GAL1 및 G10을 포함하지만 이들에 한정되지 않는다. 피치아 파스토리스 (Pichia pastoris)에 적합한 프로모터의 실례는 알코올 옥시다아제 I (AOX I) 프로모터, 글리세르알데히드 3 인산염 탈수소효소 (GAP) 프로모터, 그리고 글루타티온 의존성 포름알데히드 탈수소효소 (FLDI) 프로모터를 포함하지만 이들에 한정되지 않는다. 배큘로바이러스-매개된 시스템에 적합한 프로모터의 실례는 후기 바이러스 강한 폴리헤드린 프로모터이다.
일부 구체예에서, 핵산 분자는 단백질 정제를 용이하게 하기 위해 폴리펩티드 또는 이의 단편과 인프레임으로 태그를 인코딩한다. 태그의 실례는 본원의 다른 곳에서 개시된다. 이런 태그는 예로서, 태깅된 단백질이 모든 다른 단백질 (가령, 숙주 세포 단백질)로부터 단리될 수 있도록, 상대 리간드에 결합할 수 있다 (가령, 수지 위에 고정될 수 있다). 친화성 크로마토그래피, 고성능 액체 크로마토그래피 (HPLC) 및 크기 배제 크로마토그래피 (SEC)는 발현된 단백질의 순도를 향상시키는데 이용될 수 있는 방법의 실례이다.
폴리펩티드 또는 이들의 단편을 생산하기 위해 다른 방법이 또한 이용될 수 있다. 가령, 2개 또는 그 이상의 펩티드 또는 폴리펩티드는 단백질 화학 기술에 의해 함께 연결될 수 있다. 가령, 펩티드 또는 폴리펩티드는 Fmoc (9-플루오레닐메틸옥시카르보닐) 또는 Boc (tert -부틸옥시카르보닐) 화학을 이용하여 화학적으로 합성될 수 있다. 이런 펩티드 또는 폴리펩티드는 표준 화학 반응에 의해 합성될 수 있다. 가령, 펩티드 또는 폴리펩티드는 이의 합성 수지로부터 합성되고 개열되지 않을 수 있고, 반면 펩티드 또는 단백질의 다른 단편은 합성되고, 그리고 차후에 수지로부터 개열되고, 따라서 이러한 다른 단편 상에서 기능적으로 차단된 말단기가 노출될 수 있다. 펩티드 축합 반응에 의해, 이들 2개의 단편은 각각, 그들의 카르복실 및 아미노 말단에서 펩티드 결합을 통해 공유적으로 결합될 수 있다. 대안으로, 펩티드 또는 폴리펩티드는 본원에서 설명된 바와 같이 생체내에서 독립적으로 합성될 수 있다. 일단 단리되면, 이들 독립된 펩티드 또는 폴리펩티드는 연결되어, 유사한 펩티드 축합 반응을 통해 펩티드 또는 이의 단편을 형성할 수 있다.
일부 구체예에서, 클로닝된 또는 합성 펩티드 분절의 효소적 결찰은 상대적으로 짧은 펩티드 단편이 결합되어 더욱 큰 펩티드 단편, 폴리펩티드, 또는 전체 단백질 도메인을 생산할 수 있도록 허용한다 (Abrahmsen et al., Biochemistry, 1991, 30, 4151). 대안으로, 합성 펩티드의 선천적 화학적 결찰이 더욱 짧은 펩티드 단편으로부터 큰 펩티드 또는 폴리펩티드를 합성적으로 작제하는데 활용될 수 있다. 이러한 방법은 2-단계 화학 반응으로 구성될 수 있다 (Dawson et al., Science, 1994, 266, 776-779). 첫 번째 단계는 티오에스테르-연결된 중간체를 초기 공유 산물로서 제공하는, 아미노 말단 Cys 잔기를 내포하는 다른 비보호 펩티드 분절과 비보호 합성 펩티드-티오에스테르의 화학선택적 반응일 수 있다. 반응 조건에서 변화 없이, 이러한 중간체는 결찰 부위에서 선천적 펩티드 결합을 형성하는 자발적이고 신속한 분자내 반응을 겪을 수 있다.
일부 구체예에서, 비보호 펩티드 분절은 화학적으로 연결될 수 있는데, 여기서 화학적 결찰의 결과로서 이들 펩티드 분절 사이에 형성된 결합은 비자연적인 (비펩티드) 결합이다 (Schnolzer et al., Science, 1992, 256, 221).
일부 구체예에서, 폴리펩티드는 발현후 변형, 예를 들면, 예로서, 글리코실화, 아세틸화 및 인산화뿐만 아니라 당해 분야에서 공지된 다른 변형 (자연발생 및 비자연발생 둘 모두)을 소유할 수 있다. 폴리펩티드는 전체 단백질, 또는 이의 하위서열일 수 있다.
본 발명은 또한, 본원에서 개시된 폴리펩티드 중에서 한 가지를 생산하는 방법을 제공하는데, 이들 방법은 본원에서 개시된 폴리펩티드 중에서 한 가지 또는 그 이상을 인코딩할 수 있는 폴리뉴클레오티드를 포함하는 핵산 분자, 또는 이의 보체를 포함하는 재조합 발현 벡터를 포함하는 숙주 세포를 배양하고, 따라서 상기 폴리펩티드를 생산하는 것을 포함한다.
본 발명은 또한, 핵산 분자 중에서 한 가지 또는 그 이상뿐만 아니라 이들 핵산 분자를 포함하는 벡터 및/또는 본원에서 개시된 폴리펩티드 중에서 한 가지 또는 그 이상을 포함하는 세포 (가령, 재조합 숙주 세포)를 제공한다. 세포는 시험관내, 탈체 또는 생체내일 수 있다. 핵산 분자는 그들이 발현되어 인코딩된 단백질을 생산하도록, 프로모터 및 다른 조절 서열에 연결될 수 있다. 이런 세포의 세포주가 더욱 제공된다.
일부 구체예에서, 세포는 전능성 세포 또는 다능성 세포 (가령, 배아 줄기 (ES) 세포, 예를 들면, 설치류 ES 세포, 생쥐 ES 세포, 또는 쥐 ES 세포)이다. 전능성 세포는 임의의 세포 유형을 발생시킬 수 있는 미분화 세포를 포함하고, 그리고 다능성 세포는 하나 이상의 분화된 세포 유형으로 발달하는 능력을 소유하는 미분화 세포를 포함한다. 이런 다능성 및/또는 전능성 세포는 예로서, ES 세포 또는 ES-유사 세포, 예를 들면, 유도된 다능성 줄기 (iPS) 세포일 수 있다. ES 세포는 배아 내로 도입 시에 발달 중인 배아의 임의의 조직에 기여할 수 있는 배아-유래된 전능성 또는 다능성 세포를 포함한다. ES 세포는 배반포의 내세포괴로부터 유래될 수 있고, 그리고 3가지 척추동물 배엽 (내배엽, 외배엽 및 중배엽) 중에서 한 가지의 세포로 분화할 수 있다. 본 발명에 따라서, 배아 줄기 세포는 비인간 배아 줄기 세포일 수 있다.
일부 구체예에서, 세포는 일차 체세포, 또는 일차 체세포가 아닌 세포이다. 체세포는 배우자, 생식 세포, 생식모세포, 또는 미분화된 줄기 세포가 아닌 임의의 세포를 포함할 수 있다. 일부 구체예에서, 세포는 또한, 일차 세포일 수 있다. 일차 세포는 생물체, 장기 또는 조직으로부터 직접적으로 단리된 세포 또는 세포의 배양액을 포함한다. 일차 세포는 형질전환되지도 불멸이지도 아닌 세포를 포함한다. 일차 세포는 조직 배양 동안 이전에 계대되지 않았던, 또는 조직 배양 동안 이전에 계대되었지만 조직 배양 동안 무한히 계대될 수는 없는 생물체, 장기 또는 조직으로부터 획득된 임의의 세포를 포함한다. 이런 세포는 전통적인 기술에 의해 단리될 수 있고, 그리고 예로서, 체세포, 조혈 세포, 내피 세포, 상피 세포, 섬유모세포, 중간엽 세포, 각질세포, 멜라닌세포, 단핵구, 단핵 세포, 지방세포, 지방전구세포, 뉴런, 신경아교 세포, 간세포, 골격 근모세포 및 평활근 세포를 포함한다. 가령, 일차 세포는 결합 조직, 근육 조직, 신경계 조직, 또는 상피 조직으로부터 유래될 수 있다.
일부 구체예에서, 세포는 정상적으로는 무한히 증식할 수 없지만, 돌연변이 또는 변경으로 인해, 정상적인 세포 노화를 회피하고 그 대신에 분열을 계속 겪을 수 있다. 이런 돌연변이 또는 변경은 자연적으로 발생하거나 또는 의도적으로 유도될 수 있다. 영속화 세포의 실례는 중국 햄스터 난소 (CHO) 세포, 인간 배아 신장 세포 (가령, HEK 293 세포), 그리고 생쥐 배아 섬유모세포 세포 (가령, 3T3 세포)를 포함하지만 이들에 한정되지 않는다. 다양한 유형의 영속화 세포가 널리 알려져 있다. 영속화 또는 일차 세포는 재조합 유전자 또는 단백질을 배양하거나 또는 발현하는데 전형적으로 이용되는 세포를 포함한다. 일부 구체예에서, 세포는 분화된 세포, 예를 들면, 간 세포 (가령, 인간 간 세포)이다.
세포는 임의의 공급원으로부터 유래될 수 있다. 가령, 세포는 진핵 세포, 동물 세포, 식물 세포, 또는 진균 (가령, 효모) 세포일 수 있다. 이런 세포는 어류 세포 또는 조류 세포일 수 있거나, 또는 이런 세포는 포유류 세포, 예를 들면, 인간 세포, 비인간 포유류 세포, 설치류 세포, 생쥐 세포 또는 쥐 세포일 수 있다. 포유동물은 인간, 비인간 영장류, 원숭이, 유인원, 고양이, 개, 말, 황소, 사슴, 들소, 양, 설치류 (가령, 생쥐, 쥐, 햄스터, 기니 피그), 가축 (가령, 소 종, 예를 들면, 소, 거세소 등; 양 종, 예를 들면, 양, 염소 등; 및 돼지 종, 예를 들면, 돼지 및 멧돼지)을 포함하지만 이들에 한정되지 않는다. 조류는 닭, 칠면조, 타조, 거위, 오리 등을 포함하지만 이들에 한정되지 않는다. 가축 및 농업 동물 또한 포함된다. 용어 "비인간 동물"은 인간을 배제한다.
추가 숙주 세포는 예로서, 2016년 7월 28일자 제출된 U.S. 가출원 번호 62/367,973에서 설명되는데, 이것은 본원에서 전체적으로 참조로서 편입된다.
본원에서 개시된 핵산 분자 및 폴리펩티드는 임의의 수단에 의해 세포 내로 도입될 수 있다. 형질감염 프로토콜뿐만 아니라 핵산 또는 단백질을 세포 내로 도입하기 위한 프로토콜은 변할 수 있다. 무제한적 형질감염 방법은 리포솜, 나노입자, 칼슘, 덴드리머 및 양이온성 중합체, 예를 들면, DEAE-덱스트란 또는 폴리에틸렌이민을 이용한 화학물질-기초된 형질감염 방법을 포함한다. 비-화학적 방법은 전기천공, 초음파천공 및 광학적 형질감염을 포함한다. 입자-기초된 형질감염은 유전자 총의 이용, 또는 자석-보조된 형질감염을 포함한다. 바이러스 방법 또한 형질감염에 이용될 수 있다.
세포 내로 핵산 또는 단백질의 도입은 또한, 전기천공에 의해, 세포질내 주사에 의해, 바이러스 감염에 의해, 아데노바이러스에 의해, 아데노 연관된 바이러스에 의해, 렌티바이러스에 의해, 레트로바이러스에 의해, 형질감염에 의해, 지질-매개된 형질감염에 의해, 또는 뉴클레오펙션에 의해 매개될 수 있다. 뉴클레오펙션은 핵산 기질이 세포질로뿐만 아니라 핵막을 통해 및 핵 내로 전달될 수 있게 하는 향상된 전기천공 기술이다. 이에 더하여, 본원에서 개시된 방법에서 뉴클레오펙션의 이용은 전형적으로, 정규적인 전기천공보다 훨씬 적은 세포 (가령, 정규적인 전기천공에 의한 7 백만 개와 비교하여 단지 약 2 백만 개)를 필요로 한다. 일부 구체예에서, 뉴클레오펙션은 LONZA® NUCLEOFECTOR™ 시스템을 이용하여 수행된다.
세포 내로 핵산 또는 단백질의 도입은 또한, 미량주사에 의해 달성될 수 있다. mRNA의 미량주사는 통상적으로, 세포질 내로 이루어지고 (가령, mRNA를 번역 기구에 직접적으로 전달하기 위해), 반면 단백질 또는 DNA의 미량주사는 통상적으로, 핵 내로 이루어진다. 대안으로, 미량주사는 핵 및 세포질 둘 모두 내로 주사에 의해 실행될 수 있다: 바늘이 먼저, 핵 내로 도입될 수 있고, 그리고 첫 번째 양이 주사될 수 있고, 그리고 바늘을 세포로부터 제거하는 동안, 두 번째 양이 세포질 내로 주사될 수 있다. 뉴클레아제 작용제 단백질이 세포질 내로 주사되면, 단백질은 핵/전핵으로의 전달을 담보하기 위한 핵 국부화 신호를 포함할 수 있다.
핵산 또는 단백질을 세포 내로 도입하기 위한 다른 방법은 예로서, 벡터 전달, 입자-매개된 전달, 엑소솜-매개된 전달, 지질-나노입자-매개된 전달, 세포-투과성-펩티드-매개된 전달, 또는 이식가능-장치-매개된 전달을 포함할 수 있다. 세포를 생체내에서 변형하기 위해 핵산 또는 단백질을 개체에게 투여하는 방법은 본원의 다른 곳에서 개시된다. 세포 내로 핵산 및 단백질의 도입은 또한, 수력학적 전달 (HDD)에 의해 달성될 수 있다.
핵산 또는 단백질을 세포 내로 도입하기 위한 다른 방법은 예로서, 벡터 전달, 입자-매개된 전달, 엑소솜-매개된 전달, 지질-나노입자-매개된 전달, 세포-투과성-펩티드-매개된 전달, 또는 이식가능-장치-매개된 전달을 포함할 수 있다. 일부 구체예에서, 핵산 또는 단백질은 담체, 예를 들면, 폴리(유산) (PLA) 마이크로스피어, 폴리(D,L-유산-코글리콜산) (PLGA) 마이크로스피어, 리포솜, 미셀, 역 미셀, 지질 카클리어트, 또는 지질 미소관에 담겨 세포 내로 도입될 수 있다.
본 발명은 또한, 프로브 및 프라이머를 제공한다. 프로브 및 프라이머의 실례는 예로서 상기에서 개시된다. 본 발명은 본원에서 개시된 핵산 분자 중에서 한 가지에 특이적으로 혼성화하는 핵산 서열을 포함하는 프로브 및 프라이머를 제공한다. 가령, 프로브 또는 프라이머는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 GPR156 단백질을 인코딩하는 핵산 분자에 혼성화하거나, 또는 이러한 핵산 분자의 보체에 혼성화하는 핵산 서열을 포함할 수 있다. 일부 구체예에서, 본 발명의 프로브 또는 프라이머는 서열 번호:4에 따른 GPR156 단백질을 인코딩하는 핵산 분자에 혼성화하거나, 또는 이러한 핵산 분자의 보체에 혼성화하는 핵산 서열을 포함한다. 일부 구체예에서, 프로브 또는 프라이머는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 포함하는 GPR156 단백질을 인코딩하는 핵산 분자에 혼성화하거나, 또는 이러한 핵산 분자의 보체에 혼성화하는 핵산 서열을 포함할 수 있다. 일부 구체예에서, 프로브 또는 프라이머는 서열 번호:5에 따른 GPR156 단백질을 인코딩하는 핵산 분자에 혼성화하거나, 또는 이러한 핵산 분자의 보체에 혼성화하는 핵산 서열을 포함한다. 프로브 또는 프라이머는 임의의 적합한 길이를 포함할 수 있는데, 이것의 무제한적 실례는 길이에서 최소한 약 5개, 최소한 약 8개, 최소한 약 10개, 최소한 약 11개, 최소한 약 12개, 최소한 약 13개, 최소한 약 14개, 최소한 약 15개, 최소한 약 16개, 최소한 약 17개, 최소한 약 18개, 최소한 약 19개, 최소한 약 20개, 최소한 약 21개, 최소한 약 22개, 최소한 약 23개, 최소한 약 24개, 또는 최소한 약 25개의 뉴클레오티드를 포함한다. 바람직한 구체예에서, 프로브 또는 프라이머는 길이에서 최소한 약 18개의 뉴클레오티드를 포함한다. 프로브 또는 프라이머는 길이에서 약 10 내지 약 35개, 약 10 내지 약 30개, 약 10 내지 약 25개, 약 12 내지 약 30개, 약 12 내지 약 28개, 약 12 내지 약 24개, 약 15 내지 약 30개, 약 15 내지 약 25개, 약 18 내지 약 30개, 약 18 내지 약 25개, 약 18 내지 약 24개, 또는 약 18 내지 약 22개의 뉴클레오티드를 포함할 수 있다. 바람직한 구체예에서, 프로브 또는 프라이머는 길이에서 약 18 내지 약 30개의 뉴클레오티드이다.
본 발명은 또한, 대립유전자-특이적 프로브 및 대립유전자-특이적 프라이머를 제공한다. 본 발명의 대립유전자-특이적 프로브 또는 프라이머는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 GPR156 단백질을 인코딩하는 핵산 서열, 또는 이의 보체에 특이적으로 혼성화한다.
본 발명의 맥락에서 "특이적으로 혼성화한다"는 프로브 또는 프라이머 (가령, 대립유전자-특이적 프로브 또는 프라이머)가 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하지 않는 GPR156 단백질을 인코딩하는 핵산 서열에 혼성화하지 않는다는 것을 의미한다. 본 발명에 따른 프로브 또는 프라이머는 바람직하게는, GPR156 단백질 내에서 E533D 변이를 인코딩하는 핵산 코돈, 또는 이의 보체를 포괄한다.
따라서, 본 발명은 GPR156 단백질을 인코딩하는 핵산 서열에 상보적인 핵산 서열을 포함하는 대립유전자-특이적 프로브 또는 프라이머를 제공하는데, 여기서 상기 대립유전자-특이적 프로브 또는 프라이머는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 핵산 코돈에 상보적인 핵산 서열을 포함한다.
따라서, 본 발명에 따른 대립유전자-특이적 프로브 또는 프라이머는 서열 번호:4에 따른 위치 533에서 아스파르트산을 포함하는 GPR156 단백질을 인코딩하는 핵산 서열에 상보적인 핵산 서열을 포함한다. 본 발명에 따른 대립유전자-특이적 프로브 또는 프라이머는 GPR156 내에서 E533D 변이 및/또는 GPR156의 더욱 짧은 동종형 내에서 E529D 돌연변이를 검출하는데 이용될 수 있다. 가령, 본 발명에 따른 대립유전자-특이적 프라이머는 E533D 변이를 포함하는 GPR156 (가령, 서열 번호:4의 아미노산 서열을 가짐) 또는 이의 단편을 인코딩하는 핵산 서열을 증폭하는데 이용될 수 있다. 본 발명에 따른 대립유전자-특이적 프라이머는 또한, E529D 돌연변이를 포함하는 GPR156 동종형 (가령, 서열 번호:5의 아미노산 서열을 갖는 동종형) 또는 이의 단편의 핵산 서열을 증폭하는데 이용될 수 있다.
일부 구체예에서, 본 발명의 대립유전자-특이적 프로브 또는 프라이머는 서열 번호:4에 따른 GPR156 단백질을 인코딩하는 핵산 서열에 상보적인 핵산 서열을 포함한다. 일부 구체예에서, 대립유전자-특이적 프로브 또는 프라이머는 서열 번호:5에 따른 GPR156 단백질을 인코딩하는 핵산 서열에 상보적인 핵산 서열을 포함한다. 일부 구체예에서, 대립유전자-특이적 프로브 또는 프라이머는 서열 번호:4에 따른 위치 533, 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 포함하는 GPR156 단백질을 인코딩하는 핵산 서열에 상보적인 핵산 서열을 포함한다. 일부 구체예에서, 대립유전자-특이적 프라이머는 본원에서 개시된 핵산 분자 중에서 한 가지에 특이적으로 혼성화하는데, 여기서 아스파르트산은 코돈 GAT 또는 GAU에 의해 인코딩된다. 일부 구체예에서, 대립유전자-특이적 프라이머는 본원에서 개시된 핵산 분자 중에서 한 가지에 특이적으로 혼성화하는데, 여기서 아스파르트산은 코돈 GAC에 의해 인코딩된다. 아스파르트산-인코딩 코돈은 대립유전자-특이적 프라이머의 3' 단부에 있을 수 있다.
바람직한 구체예에서, 대립유전자-특이적 프로브 또는 프라이머는 GPR156 유전자의 다수 대립유전자에 결합한다. 따라서, 대립유전자-특이적 프라이머는 바람직하게는, GPR156 유전자의 다수 대립유전자에는 결합하고 GPR156 유전자의 소수 대립유전자에는 결합하지 않는다. 비록 야생형 다수 대립유전자가 서열 번호:4의 위치 533에 상응하는 위치에서 글루타민산을 인코딩하는 핵산 서열을 포함하긴 하지만, 다수 대립유전자는 서열 번호:4의 위치 516에 상응하는 위치에서 아스파르트산을 인코딩하는 핵산 서열을 포함한다. 비록 소수 대립유전자가 서열 번호:4의 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 핵산 서열을 포함하긴 하지만, 소수 대립유전자는 서열 번호:4의 위치 516에 상응하는 위치에서 글루타민산을 인코딩하는 핵산 서열을 포함한다. 따라서, 대립유전자-특이적 프로브 또는 프라이머는 E533D 변이를 포함하는 GRP156 유전자의 소수 대립유전자에 특이적으로 혼성화할 수 있다. 본 발명에 따라서, 대립유전자-특이적 프로브 또는 프라이머는 E533D 변이를 포함하지 않는 다수 대립유전자에 혼성화하지 않는다.
본 발명의 대립유전자-특이적 프로브 또는 프라이머에 대해서도 필요한 부분만 약간 수정하여, 본 발명의 프로브 또는 프라이머에 대하여 전술된 길이가 적용된다.
본 발명은 또한, 전술된 대립유전자-특이적 프라이머 중에서 한 가지를 포함하는 한 쌍의 대립유전자-특이적 프라이머를 제공한다.
일부 구체예에서, 프로브 또는 프라이머 (가령, 대립유전자-특이적 프로브 또는 프라이머)는 DNA를 포함한다. 일부 구체예에서, 프로브 또는 프라이머 (가령, 대립유전자-특이적 프로브 또는 프라이머)는 RNA를 포함한다. 일부 구체예에서, 프로브 (가령, 대립유전자-특이적 프로브)는 본원에서 개시된 핵산 분자 중에서 한 가지에 혼성화하는데, 여기서 아스파르트산 (서열 번호:4에 따른 위치 533에 상응하는 위치에서)은 코돈 GAT (또는 GAU)에 의해 인코딩된다. 일부 구체예에서, 프로브는 본원에서 개시된 핵산 분자 중에서 한 가지에 혼성화하는데, 여기서 아스파르트산 (서열 번호:4에 따른 위치 533에 상응하는 위치에서)은 코돈 GAC에 의해 인코딩된다. 일부 구체예에서, 프로브 (가령, 대립유전자-특이적 프로브)는 엄격한 조건, 예를 들면, 높은 엄격한 조건 하에 인간 GPR156 단백질을 인코딩하는 핵산 서열에 혼성화한다.
일부 구체예에서, 프로브는 표지를 포함한다. 일부 구체예에서, 표지는 형광 표지, 방사성 표지, 또는 비오틴이다. 일부 구체예에서, 프로브의 길이는 전술된다. 대안으로, 일부 구체예에서, 프로브는 최소한 약 20개, 최소한 약 25개, 최소한 약 30개, 최소한 약 35개, 최소한 약 40개, 최소한 약 45개, 최소한 약 50개, 최소한 약 55개, 최소한 약 60개, 최소한 약 65개, 최소한 약 70개, 최소한 약 75개, 최소한 약 80개, 최소한 약 85개, 최소한 약 90개, 최소한 약 95개, 또는 최소한 약 100개의 뉴클레오티드를 포함하거나 또는 이들로 구성된다. 프로브 (가령, 대립유전자-특이적 프로브)는 예로서, 본원에서 개시된 핵산 분자 중에서 한 가지를 검출하는데 이용될 수 있다. 바람직한 구체예에서, 프로브는 길이에서 최소한 약 18개의 뉴클레오티드를 포함한다. 프로브는 길이에서 약 10 내지 약 35개, 약 10 내지 약 30개, 약 10 내지 약 25개, 약 12 내지 약 30개, 약 12 내지 약 28개, 약 12 내지 약 24개, 약 15 내지 약 30개, 약 15 내지 약 25개, 약 18 내지 약 30개, 약 18 내지 약 25개, 약 18 내지 약 24개, 또는 약 18 내지 약 22개의 뉴클레오티드를 포함할 수 있다. 바람직한 구체예에서, 프로브는 길이에서 약 18 내지 약 30개의 뉴클레오티드이다.
본 발명은 또한, 본원에서 개시된 프로브 중에서 한 가지 또는 그 이상이 부착되는 기질을 포함하는 지지체를 제공한다. 고체 지지체는 분자, 예를 들면, 본원에서 개시된 프로브 중에서 한 가지가 연관될 수 있는 고체-상태 기질 또는 지지체이다. 고체 지지체의 형태는 어레이이다. 고체 지지체의 다른 형태는 어레이 검출기이다. 어레이 검출기는 복수의 상이한 프로브가 어레이, 격자, 또는 다른 조직화된 패턴으로 연계된 고체 지지체이다.
고체 지지체에서 이용을 위한 고체-상태 기질은 분자가 연계될 수 있는 임의의 고체 물질을 포함할 수 있다. 이것은 물질, 예를 들면, 아크릴아미드, 아가로오스, 셀룰로오스, 니트로셀룰로오스, 유리, 폴리스티렌, 폴리에틸렌 비닐 아세트산염, 폴리프로필렌, 폴리메타크릴레이트, 폴리에틸렌, 폴리에틸렌 산화물, 폴리규산염, 폴리카보네이트, 테플론, 탄화플루오르, 나일론, 실리콘 고무, 폴리무수물, 폴리글리콜산, 폴리유산, 폴리오르토에스테르, 폴리프로필푸머레이트, 콜라겐, 글리코사미노글리칸 및 폴리아미노산을 포함한다. 고체-상태 기질은 박막, 막, 병, 접시, 섬유, 직조 섬유, 성형된 중합체, 입자, 비드, 마이크로입자, 또는 조합을 비롯한 임의의 유용한 형태를 가질 수 있다. 고체-상태 기질 및 고체 지지체는 다공성 또는 비-다공성일 수 있다. 고체-상태 기질에 대한 형태는 마이크로역가 접시, 예를 들면, 표준 96-웰 유형이다. 일부 구체예에서, 웰마다 하나의 어레이를 통상적으로 내포하는 다중웰 유리 슬라이드가 이용될 수 있다. 이러한 특질은 검정 재현성의 더욱 큰 제어, 증가된 처리량 및 표본 취급, 그리고 자동화의 용이성을 허용한다. 일부 구체예에서, 지지체는 마이크로어레이이다.
본원에서 개시된 폴리펩티드 중에서 한 가지는 본원에서 설명된 바와 같은 위치 533 또는 529에서 아스파르트산에 추가하여, 하나 또는 그 이상의 치환 (가령, 보존성 아미노산 치환), 삽입 또는 결실을 더욱 가질 수 있다. 삽입은 예로서, 아미노 또는 카르복실 말단 융합뿐만 아니라 단일 또는 복수 아미노산 잔기의 서열내 삽입을 포함한다. 공지된 서열을 갖는 DNA 내에 미리 결정된 부위에서 치환을 만들기 위한 기술, 예를 들면, M13 프라이머 돌연변이유발 및 PCR 돌연변이유발은 널리 알려져 있다. 아미노산 치환은 전형적으로, 단일 잔기의 치환이지만, 다수의 상이한 위치에서 한꺼번에 일어날 수 있다; 삽입은 통상적으로, 대략 약 1 내지 10개의 아미노산 잔기일 것이다; 그리고 결실은 약 1 내지 30개 잔기의 범위에서 변할 것이다. 결실 또는 삽입은 인접한 쌍에서 만들어질 수 있다 (다시 말하면, 2개 잔기의 결실 또는 2개 잔기의 삽입). 치환, 결실, 삽입 또는 이들의 임의의 조합은 조합되어 최종 구조체에 도달할 수 있다. 일부 구체예에서, 이들 돌연변이는 서열을 해독틀의 밖에 배치하지 않고, 그리고 이차 mRNA 구조를 생산할 수 있는 상보성 영역을 창출하지 않는다.
본 발명은 또한, 본원에서 설명된 조성물을 만들고 본원에서 설명된 방법을 활용하기 위한 키트를 제공한다. 본원에서 설명된 키트는 개체의 표본 내에서 하나 또는 그 이상의 유전자 변이체를 검출하기 위한 검정 또는 검정들을 포함할 수 있다.
일부 구체예에서, GPR156 변이체의 인간 확인을 위한 키트는 전술된 조성물 및 방법을 활용한다. 일부 구체예에서, 기본 키트는 본원에서 개시된 핵산 분자 (가령, 예로서, 서열 번호:9 내지 12, 서열 번호:16 내지 21, 또는 서열 번호:25 내지 30) 중에서 한 가지에서 하나의 좌위에 대한 올리고뉴클레오티드 프라이머의 최소한 하나의 쌍을 갖는 용기를 포함할 수 있다. 키트는 또한, 사용설명서를 임의선택적으로 포함할 수 있다. 키트는 또한, 다른 임의선택적 키트 성분, 예를 들면, 예로서, 증폭된 좌위 각각을 향해 지향된 대립유전자 사다리, 증폭을 위한 충분한 양의 효소, 증폭을 조장하는 증폭 완충액, 효소 활성을 조장하는 이가 양이온 용액, 증폭 동안 가닥 확장을 위한 dNTPs, 전기이동용 증폭된 물질의 제조를 위한 부하 용액, 주형 대조로서 유전체 DNA, 물질이 분리 배지에서 예상한 대로 이주하도록 담보하기 위한 크기 마커, 그리고 사용자를 교육하고 이용 시에 오차를 제한하기 위한 프로토콜 및 매뉴얼 중에서 하나 또는 그 이상을 포함할 수 있다. 키트 내에 다양한 시약의 양 역시 다수의 인자, 예를 들면, 과정의 최적 민감도에 따라 변할 수 있다. 수동 적용에서 이용을 위한 검사 키트, 또는 자동화된 표본 준비, 반응 설정, 검출기 또는 분석기용의 검사 키트를 제공하는 것은 이들 교시의 범위 내에 있다.
일부 구체예에서, 키트는 아스파르트산을 인코딩하는 최소한 하나의 좌위의 증폭을 위한 올리고뉴클레오티드 프라이머의 최소한 하나의 쌍을 포함하는데, 여기서 상기 쌍의 한쪽 프라이머는 최소한 하나의 좌위의 프라이머 결합 부위 내에서 SNP 핵염기에 혼성화하고, 그리고 상기 쌍의 최소한 하나의 프라이머는 형광 표지를 포함한다. 일부 양상에서, 좌위는 GPR156 유전자에서 변이체를 포함한다.
일부 구체예에서, 키트는 본원에서 개시된 핵산 분자 (가령, 예로서, 서열 번호:9 내지 12, 서열 번호:16 내지 21, 또는 서열 번호:25 내지 30) 중에서 한 가지에서 선택되는 최소한 하나의 좌위의 PCR 증폭을 위한 올리고뉴클레오티드 프라이머의 최소한 하나의 쌍을 포함하는데, 여기서 상기 쌍의 한쪽 프라이머는 최소한 하나의 좌위의 프라이머 결합 부위 내에서 SNP 핵염기에 혼성화한다. 일부 구체예에서, 키트는 본원에서 개시된 핵산 분자 (가령, 예로서, 서열 번호:9 내지 12, 서열 번호:16 내지 21, 또는 서열 번호:25 내지 30) 중에서 한 가지에서 선택되는 최소한 하나의 좌위에 상응하는 대립유전자 사다리, 프로토콜, 효소, dNTPs, 완충액, 염 또는 염들 중에서 최소한 하나, 그리고 대조 핵산 표본을 더욱 포함한다. 일부 구체예에서, SNP 핵염기는 본원에서 개시된 핵산 분자 (가령, 예로서, 서열 번호:9 내지 12, 서열 번호:16 내지 21, 또는 서열 번호:25 내지 30) 중에서 한 가지에서 선택되는 서열 내에 있다.
일부 양상에서, 본원에서 개시된 키트는 본원에서 개시된 cDNA 또는 mRNA 분자 (가령, 예로서, 서열 번호:16 내지 21, 또는 서열 번호:25 내지 30) 중에서 한 가지의 뉴클레오티드 위치 1599에서 티민 또는 우라실에 직접적으로 혼성화하는 3' 말단 뉴클레오티드를 포함하는 프라이머를 포함할 수 있다.
다음을 포함하는 키트 역시 본원에서 개시된다: 서열 번호:4의 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에서 본원에서 개시된 핵산 분자 중에서 한 가지에서 뉴클레오티드 변동을 검출하도록 설계된 최소한 하나의 핵산 프로브, 여기서 검출은 뉴클레오티드 변동 서열에 대한 특정한 혼성화에 근거되고, 여기서 상기 핵산 프로브는 검출가능한 표지, 산물 및 어닐링 반응을 실행하는데 필요한 시약을 포함한다; 그리고 사용설명서. 키트는 본원에서 설명된 프로브 중에서 한 가지를 포함할 수 있다.
다음을 포함하는 키트가 본원에서 개시된다: 서열 번호:4의 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에서 본원에서 개시된 핵산 분자 중에서 한 가지의 최소한 하나의 좌위의 증폭을 위한 올리고뉴클레오티드 프라이머의 최소한 하나의 쌍, 여기서 상기 쌍의 한쪽 프라이머는 최소한 하나의 좌위의 프라이머 결합 부위 내에서 SNP 핵염기에 혼성화하고, 그리고 상기 쌍의 최소한 하나의 프라이머는 형광 표지를 포함한다. 키트는 본원에서 설명된 프라이머 중에서 한 가지를 포함할 수 있다.
서열 번호:4의 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에서 본원에서 개시된 핵산 분자 중에서 한 가지의 최소한 하나의 좌위의 증폭을 위한 올리고뉴클레오티드 프라이머의 최소한 하나의 쌍을 포함하는 키트가 본원에서 개시되는데, 여기서 상기 쌍의 한쪽 프라이머는 최소한 하나의 좌위의 프라이머 결합 부위 내에서 SNP 핵염기에 혼성화하고, 그리고 상기 쌍의 최소한 하나의 프라이머는 서열 번호:4의 위치 533에 상응하는 아스파르트산을 인코딩하는 위치에서 본원에서 개시된 핵산 분자 중에서 한 가지의 최소한 하나의 좌위에 상응하는 대립유전자 사다리를 더욱 포함하는 형광 표지를 포함한다. 키트는 본원에서 설명된 프라이머 중에서 한 가지를 포함할 수 있다.
서열 번호:4의 위치 533에 상응하는 아스파르트산을 인코딩하는 위치에서 본원에서 개시된 핵산 분자 중에서 한 가지의 최소한 하나의 좌위의 증폭을 위한 올리고뉴클레오티드 프라이머의 최소한 하나의 쌍을 포함하는 키트가 본원에서 개시되는데, 여기서 상기 쌍의 한쪽 프라이머는 최소한 하나의 좌위의 프라이머 결합 부위 내에서 SNP 핵염기에 혼성화하고, 그리고 상기 쌍의 최소한 하나의 프라이머는 형광 표지를 포함하고, 여기서 이들 프라이머는 중합효소 연쇄 반응 (PCR)에서 이용된다. 키트는 본원에서 설명된 프라이머 중에서 한 가지를 포함할 수 있다.
서열 번호:4의 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에서 본원에서 개시된 핵산 분자 중에서 한 가지의 최소한 하나의 좌위의 증폭을 위한 올리고뉴클레오티드 프라이머의 최소한 하나의 쌍을 포함하는 키트가 본원에서 개시되는데, 여기서 상기 쌍의 한쪽 프라이머는 최소한 하나의 좌위의 프라이머 결합 부위 내에서 SNP 핵염기에 혼성화하고, 그리고 상기 쌍의 최소한 하나의 프라이머는 형광 표지를 포함하고, 프로토콜, 효소, dNTPs, 완충액, 염 또는 염들 및 대조 핵산 표본 중에서 최소한 하나를 더욱 포함한다. 키트는 본원에서 설명된 프라이머 중에서 한 가지를 포함할 수 있다.
표 1. 프라이머
| 전방 프라이머 (5'→ 3') | 서열 번호: | 후방 프라이머 (5'→ 3') | 서열 번호 |
| TCTCCCCAG | 31 | ||
| AGAGGGGTC | 32 | ||
| TCTCCCCAT | 33 | ||
| AGAGGGGA | 34 | ||
| CCAGAGTCTCCTACCAGATAG | 35 | AGAAGGCTGGCGAAGAAAGG | 36 |
| CAACGCCAAAGAGAAGATTG | 37 | CTTCCAGGTTTGCTGATGACA | 38 |
| AAGATATCTGACTCAAAAGAC | 39 | AGAGCCAGGAAAGTGTGAGC | 40 |
| TTTCAGAATGATCCTGGCATG | 41 | ACTGTTCTTCCAGGTTTGCTG | 42 |
당업자는 이용된 검출 기술이 일반적으로, 제한하는 것이 아니라는 것을 이해한다. 오히려, 매우 다양한 검출 수단이 앰플리콘의 존재 또는 부재가 결정될 수 있도록 허용한다면, 이들은 개시된 방법 및 키트의 범위 내에 있다.
일부 양상에서, 키트는 본원에서 개시된 프라이머 또는 프로브 중에서 하나 또는 그 이상을 포함할 수 있다. 가령, 키트는 개시된 유전자 변이체 중에서 하나 또는 그 이상에 혼성화하는 하나 또는 그 이상의 프로브를 포함할 수 있다.
일부 양상에서, 키트는 개시된 세포 또는 세포주 중에서 한 가지를 포함할 수 있다. 일부 양상에서, 키트는 유전자도입 세포 또는 세포주를 창출하는데 필요한 물질을 포함할 수 있다. 가령, 일부 양상에서 키트는 개시된 유전자 변이체 중에서 하나 또는 그 이상을 포함하는 핵산 서열을 포함하는 세포 및 벡터를 포함할 수 있다. 키트는 세포 배양용 배지를 더욱 포함할 수 있다.
본 발명은 또한, 인간 개체로부터 생물학적 표본에서 GPR156 변이체 유전자, mRNA, cDNA 및/또는 폴리펩티드의 존재를 검출하기 위한 방법을 제공한다. 개체군 내에 유전자 서열, 그리고 이런 유전자에 의해 인코딩된 mRNA 및 단백질은 다형성, 예를 들면, 단일-뉴클레오티드 다형성으로 인해 변할 수 있는 것으로 이해된다. GPR156 유전자, mRNA, cDNA 및 폴리펩티드에 대해 본원에서 제공된 서열은 단지 예시적인 서열이다. GPR156 유전자, mRNA, cDNA 및 폴리펩티드에 대한 다른 서열 역시 가능하다.
생물학적 표본은 개체로부터 임의의 세포, 조직 또는 생물학적 유체로부터 유래될 수 있다. 표본은 임의의 임상적으로 유관한 조직, 예를 들면, 골수 표본, 종양 생검, 미세바늘 흡인물, 또는 체액, 예를 들면, 혈액, 치은 열구액, 혈장, 혈청, 림프, 복수, 낭성 유체 또는 소변의 표본을 포함할 수 있다. 일부 경우에, 표본은 구강 면봉을 포함한다. 본원에서 개시된 방법에서 이용된 표본은 검정 형식, 검출 방법의 성격, 그리고 표본으로서 이용되는 조직, 세포 또는 추출물에 근거하여 변할 것이다. 생물학적 표본은 이용되는 검정에 따라 상이하게 처리될 수 있다. 가령, 변이체 GPR156 핵산 분자를 검출할 때, 유전체 DNA에 대한 표본을 단리하거나 또는 농축하도록 설계된 예비적 처리가 이용될 수 있다. 다양한 공지된 기술이 이러한 목적으로 이용될 수 있다. 변이체 GPR156 mRNA의 수준을 검출할 때, 상이한 기술이 mRNA를 갖는 생물학적 표본을 농축하는데 이용될 수 있다. mRNA의 존재 또는 수준, 또는 특정 변이체 유전체 DNA 좌위의 존재를 검출하는 다양한 방법이 이용될 수 있다.
일부 구체예에서, 본 발명은 변이체 GPR156 핵산 분자의 존재 또는 부재를 검출하는 방법을 제공하는데, 이들 방법은 생물학적 표본에서 핵산의 최소한 일부를 염기서열결정하여, 상기 핵산이 서열 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 핵산 서열을 포함하는 지를 결정하는 것을 포함한다. 본원에서 개시된 변이체 핵산 분자 중에서 한 가지는 본원에서 설명된 프로브 중에서 한 가지를 이용하여 검출될 수 있다.
일부 구체예에서, 개체에서 단극성 우울증-연관된 변이체 GPR156 핵산 분자 (가령, 유전자, mRNA 또는 cDNA)의 존재 또는 부재를 검출하는 방법, 이들 방법은 개체로부터 획득된 생물학적 표본에서 검정을 수행하는 것을 포함하고, 상기 검정은 생물학적 표본에서 핵산 분자가 서열 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 핵산 서열을 포함하는 지를 결정한다. 일부 구체예에서, 생물학적 표본은 세포 또는 세포 용해물을 포함한다. 이런 방법은 예로서, GPR156 유전자 또는 mRNA를 포함하는 개체로부터 생물학적 표본을 획득하고, 그리고 mRNA이면, 상기 mRNA를 cDNA로 임의선택적으로 역전사하고, 그리고 GPR156 유전자, mRNA 또는 cDNA의 위치가 변이체 GPR156 폴리펩티드의 위치 533에 상응하는 위치에서 아스파르트산을 인코딩한다는 것을 결정하는 검정을 상기 생물학적 표본에서 수행하는 것을 더욱 포함할 수 있다. 이런 검정은 예로서, 특정 GPR156 핵산 분자의 이들 위치의 정체를 결정하는 것을 포함할 수 있다. 일부 구체예에서, 개체는 인간이다.
일부 구체예에서, 개체에서 불안 장애-연관된 변이체 GPR156 핵산 분자 (가령, 유전자, mRNA 또는 cDNA)의 존재 또는 부재를 검출하는 방법, 이들 방법은 개체로부터 획득된 생물학적 표본에서 검정을 수행하는 것을 포함하고, 상기 검정은 생물학적 표본에서 핵산 분자가 서열 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 핵산 서열을 포함하는 지를 결정한다. 일부 구체예에서, 생물학적 표본은 세포 또는 세포 용해물을 포함한다. 이런 방법은 예로서, GPR156 유전자 또는 mRNA를 포함하는 개체로부터 생물학적 표본을 획득하고, 그리고 mRNA이면, 상기 mRNA를 cDNA로 임의선택적으로 역전사하고, 그리고 GPR156 유전자, mRNA 또는 cDNA의 위치가 변이체 GPR156 폴리펩티드의 위치 533에 상응하는 위치에서 아스파르트산을 인코딩한다고 결정하는 검정을 상기 생물학적 표본에서 수행하는 것을 더욱 포함할 수 있다. 이런 검정은 예로서, 특정 GPR156 핵산 분자의 이들 위치의 정체를 결정하는 것을 포함할 수 있다. 일부 구체예에서, 개체는 인간이다.
일부 구체예에서, 검정은 다음을 포함한다: 개체로부터 생물학적 표본에서 핵산 분자의 GPR156 유전체 서열의 최소한 일부를 염기서열결정함, 여기서 염기서열결정된 부분은 서열 번호:4에 따른 GPR156 단백질에서 위치 533에서, 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 상응하는 위치를 포함한다; 개체로부터 생물학적 표본에서 핵산 분자의 GPR156 mRNA 서열의 부분을 염기서열결정함, 여기서 염기서열결정된 부분은 서열 번호:4에 따른 GPR156 단백질에서 위치 533에서, 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 상응하는 위치를 포함한다; 또는 개체로부터 획득된 생물학적 표본으로부터 획득된 mRNA로부터 획득된 핵산 분자의 GPR156 cDNA 서열의 부분을 염기서열결정함, 여기서 염기서열결정된 부분은 서열 번호:4에 따른 GPR156 단백질에서 위치 533에서, 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 상응하는 위치를 포함한다.
일부 구체예에서, 검정은 다음을 포함한다: a) 생물학적 표본을 i) 서열 번호:4에 따른 위치 533에서, 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 상응하는 위치에서 GPR156 유전체 서열의 위치에 가장 가깝게 있는 GPR156 유전체 서열의 부분; ii) 서열 번호:4에 따른 위치 533에서, 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 상응하는 GPR156 mRNA의 위치에 가장 가깝게 있는 GPR156 mRNA 서열의 부분; 또는 iii) 서열 번호:4에 따른 위치 533에서, 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 상응하는 GPR156 cDNA의 위치에 가장 가깝게 있는 GPR156 cDNA 서열의 부분에 혼성화하는 프라이머와 접촉시키고; b) 상기 프라이머를 최소한 i) 서열 번호:4에 따른 위치 533에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈을 뛰어넘는 뉴클레오티드 위치에 상응하는 GPR156 유전체 서열의 위치; ii) 서열 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈을 뛰어넘는 뉴클레오티드 위치에 상응하는 GPR156 mRNA의 위치; 또는 iii) 서열 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 코돈을 뛰어넘는 뉴클레오티드 위치에 상응하는 GPR156 cDNA의 위치를 통해 확장하고; 그리고 c) 프라이머의 확장 산물이 서열 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 뉴클레오티드를 포함하는 지를 결정함. 일부 구체예에서, 단지 GPR156 유전체 DNA만 분석된다. 일부 구체예에서, 단지 GPR156 mRNA만 분석된다. 일부 구체예에서, GPR156 mRNA로부터 획득된 GPR156 cDNA만 분석된다.
일부 구체예에서, 검정은 다음을 포함한다: a) 생물학적 표본을 i) 서열 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아미노산을 인코딩하는 뉴클레오티드를 포함하는 GPR156 유전체 서열의 부분; ii) 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아미노산 서열을 인코딩하는 뉴클레오티드를 포함하는 GPR156 mRNA 서열의 부분; 또는 iii) 서열 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아미노산을 인코딩하는 뉴클레오티드를 포함하는 GPR156 cDNA 서열의 부분에 혼성화하는 대립유전자-특이적 프라이머와 접촉시키고; b) 대립유전자-특이적 중합효소 연쇄 반응 기술을 이용하여 프라이머를 확장하고; 그리고 c) 확장이 일어났는 지를 결정함. 대립유전자-특이적 중합효소 연쇄 반응 기술이 핵산 서열에서 돌연변이, 예를 들면, SNPs를 검출하는데 이용될 수 있다. 대립유전자-특이적 프라이머는 주형과의 부정합이 존재할 때 DNA 중합효소가 확장하지 않을 것이기 때문에 이용된다. 기본 대립유전자-특이적 중합효소 연쇄 반응 기술의 다양한 변이는 당업자의 처분에 달려 있다.
대립유전자-특이적 프라이머는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 포함하는 GPR156 단백질을 인코딩하는 핵산 서열에 상보적인 핵산 서열, 또는 상기 핵산 서열에 대한 보체를 포함할 수 있다. 가령, 대립유전자-특이적 프라이머는 서열 번호:4 및/또는 서열 번호:5를 인코딩하는 핵산 서열에 상보적인 핵산 서열, 또는 이러한 핵산 서열에 대한 보체를 포함할 수 있다. 대립유전자-특이적 프라이머는 바람직하게는, GPR156 단백질을 인코딩하는 핵산 서열이 코돈 GAT (또는 GAU) 또는 GAC를 통해 서열 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩할 때, 상기 핵산 서열에 특이적으로 혼성화한다.
일부 구체예에서, 검정은 생물학적 표본을, 엄격한 조건 하에 변이체 GPR156 유전체 서열, mRNA 서열 또는 cDNA 서열에는 특이적으로 혼성화하지만 상응하는 야생형 GPR156 서열에는 혼성화하지 않는 프라이머 또는 프로브와 접촉시키고, 그리고 혼성화가 일어났는 지를 결정하는 것을 포함한다.
일부 구체예에서, 검정은 RNA 염기서열결정 (RNA-Seq)을 포함한다. 일부 구체예에서, 검정은 또한, 역전사효소 중합효소 연쇄 반응 (RT-PCR)을 통해 mRNA를 cDNA로 역전사하는 것을 포함한다.
일부 구체예에서, 이들 방법은 표적 핵산 서열에 결합하고, 그리고 변이체 GPR156 유전자, mRNA 또는 cDNA를 포함하는 폴리뉴클레오티드를 특이적으로 검출하고 및/또는 확인하는데 충분한 뉴클레오티드 길이의 프로브 및 프라이머를 활용한다. 혼성화 조건 또는 반응 조건은 이러한 결과를 달성하기 위해 오퍼레이터에 의해 결정될 수 있다. 이러한 뉴클레오티드 길이는 본원에서 설명되거나 또는 예시된 임의의 검정을 비롯하여, 선택되는 검출 방법에서 이용하는데 충분한 임의의 길이일 수 있다. 일반적으로, 예로서, 길이에서 약 8개, 약 10개, 약 11개, 약 12개, 약 14개, 약 15개, 약 16개, 약 18개, 약 20개, 약 22개, 약 24개, 약 26개, 약 28개, 약 30개, 약 40개, 약 50개, 약 75개, 약 100개, 약 200개, 약 300개, 약 400개, 약 500개, 약 600개, 또는 약 700개 뉴클레오티드, 또는 그 이상, 또는 약 11 내지 약 20개, 약 20 내지 약 30개, 약 30 내지 약 40개, 약 40 내지 약 50개, 약 50 내지 약 100개, 약 100 내지 약 200개, 약 200 내지 약 300개, 약 300 내지 약 400개, 약 400 내지 약 500개, 약 500 내지 약 600개, 약 600 내지 약 700개, 또는 약 700 내지 약 800개, 또는 그 이상의 뉴클레오티드를 갖는 프라이머 또는 프로브가 이용된다. 바람직한 구체예에서, 프로브 또는 프라이머는 길이에서 최소한 약 18개의 뉴클레오티드를 포함한다. 프로브 또는 프라이머는 길이에서 약 10 내지 약 35개, 약 10 내지 약 30개, 약 10 내지 약 25개, 약 12 내지 약 30개, 약 12 내지 약 28개, 약 12 내지 약 24개, 약 15 내지 약 30개, 약 15 내지 약 25개, 약 18 내지 약 30개, 약 18 내지 약 25개, 약 18 내지 약 24개, 또는 약 18 내지 약 22개의 뉴클레오티드를 포함할 수 있다. 바람직한 구체예에서, 프로브 또는 프라이머는 길이에서 약 18 내지 약 30개의 뉴클레오티드이다.
이런 프로브 및 프라이머는 높은 엄격함 혼성화 조건 하에 표적 서열에 특이적으로 혼성화할 수 있다. 비록 표적 핵산 서열과 다르지만 표적 핵산 서열을 특이적으로 검출하고 및/또는 확인하는 능력을 유지하는 프로브가 전통적인 방법에 의해 설계될 수 있긴 하지만, 프로브 및 프라이머는 인접한 뉴클레오티드의 표적 서열과의 완전한 핵산 서열 동일성을 가질 수 있다. 따라서, 프로브 및 프라이머는 표적 핵산 분자와 약 80%, 약 85%, 약 90%, 약 91%, 약 92%, 약 93%, 약 94%, 약 95%, 약 96%, 약 97%, 약 98%, 약 99%, 또는 100% 서열 동일성 또는 상보성을 공유할 수 있다.
일부 구체예에서, 특정한 프로브로서 이용될 수 있거나, 또는 변이체 GPR156 좌위를 확인하기 위해 또는 생물학적 표본에서 특정한 GPR156 mRNA 또는 cDNA의 수준을 결정하기 위해 그 자체가 검출될 수 있는 앰플리콘을 생산하기 위해, 특이적 프라이머가 변이체 GPR156 좌위 및/또는 GPR156 변이체 mRNA 또는 cDNA를 증폭하는데 이용될 수 있다. GPR156 변이체 좌위는 서열 번호:4에 따른 위치 533에서 또는 서열 번호:5에 따른 위치 529에서 아스파르트산을 인코딩하는 위치에 상응하는 위치를 포함하는 유전체 핵산 서열을 표시하는데 이용될 수 있다. 핵산 분자에 프로브의 결합을 허용하는 조건 하에 생물학적 표본에서 프로브가 핵산 분자와 혼성화될 때, 이러한 결합은 검출되고, 그리고 변이체 GPR156 좌위의 존재, 또는 생물학적 표본에서 변이체 GPR156 mRNA 또는 cDNA의 존재 또는 수준의 지시를 허용할 수 있다. 결합된 프로브의 이런 확인은 설명되었다. 특정한 프로브는 변이체 GPR156 유전자의 특정한 영역에 최소한 약 80%, 약 80% 내지 약 85%, 약 85% 내지 약 90%, 약 90% 내지 약 95%, 그리고 약 95% 내지 약 100% 동일한 (또는 상보적인) 서열을 포함할 수 있다. 특정한 프로브는 변이체 GPR156 mRNA의 특정한 영역에 최소한 약 80%, 약 80% 내지 약 85%, 약 85% 내지 약 90%, 약 90% 내지 약 95%, 그리고 약 95% 내지 약 100% 동일한 (또는 상보적인) 서열을 포함할 수 있다. 특정한 프로브는 변이체 GPR156 cDNA의 특정한 영역에 최소한 약 80%, 약 80% 내지 약 85%, 약 85% 내지 약 90%, 약 90% 내지 약 95%, 그리고 약 95% 내지 약 100% 동일한 (또는 상보적인) 서열을 포함할 수 있다.
일부 구체예에서, 생물학적 표본의 핵산 보체가 서열 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 핵산 서열을 포함하는 지를 결정하기 위해, 생물학적 표본은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에서 SNP의 존재에 대해 진단적인 앰플리콘을 생산하기 위해 서열 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 인접한 5' 측면 서열로부터 유래된 첫 번째 프라이머, 그리고 서열 번호:4에 따른 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 위치에 인접한 3' 측면 서열로부터 유래된 두 번째 프라이머를 포함하는 프라이머 쌍을 이용하는 핵산 증폭 방법에 종속될 수 있다. 일부 구체예에서, 앰플리콘은 길이에서 프라이머 쌍 플러스 1개 뉴클레오티드 염기쌍의 조합된 길이로부터 DNA 증폭 프로토콜에 의해 생산가능한 앰플리콘의 임의의 길이까지의 범위에서 변할 수 있다. 이러한 거리는 1개 뉴클레오티드 염기쌍으로부터 증폭 반응의 한계, 또는 약 2만개 뉴클레오티드 염기쌍까지의 범위에서 변할 수 있다. 임의선택적으로, 프라이머 쌍은 서열 번호:4에 따른 위치 533에서 또는 서열 번호:5에 따른 위치 529에서 아스파르트산을 인코딩하는 위치, 그리고 서열 번호:4에 따른 위치 533에서 또는 서열 번호:5에 따른 위치 529에서 아스파르트산을 인코딩하는 위치의 각 측면에서 최소한 1, 2, 3, 4, 5, 6, 7, 8, 9, 10개, 또는 그 이상의 뉴클레오티드를 포함하는 영역에 접한다. 유사한 앰플리콘은 mRNA 및/또는 cDNA 서열로부터 산출될 수 있다.
프로브 및 프라이머를 제조하고 이용하기 위한 대표적인 방법은 가령, Molecular Cloning: A Laboratory Manual, 2nd Ed., Vol. 1-3, ed. Sambrook et al., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. 1989 (이하, "Sambrook et al., 1989"); Current Protocols in Molecular Biology, ed. Ausubel et al., Greene Publishing and Wiley-Interscience, New York, 1992 (주기적으로 갱신됨) (이하, "Ausubel et al., 1992"); 및 Innis et al., PCR Protocols: A Guide to Methods and Applications, Academic Press: San Diego, 1990)에서 설명된다. PCR 프라이머 쌍은 예로서, 상기 목적으로 의도된 컴퓨터 프로그램, 예를 들면, Vector NTI 버전 10에서 PCR 프라이머 분석 도구 (Informax Inc., Bethesda Md.); PrimerSelect (DNASTAR Inc., Madison, Wis.); 및 Primer3 (Version 0.4.0.COPYRGT., 1991, Whitehead Institute for Biomedical Research, Cambridge, Mass.)을 이용함으로써, 공지된 서열로부터 유래될 수 있다. 추가적으로, 서열은 시각적으로 스캔될 수 있고, 그리고 프라이머는 공지된 지침을 이용하여 수동으로 확인될 수 있다.
임의의 핵산 혼성화 또는 증폭 또는 염기서열결정 방법이 변이체 GPR156 유전자 좌위의 존재 및/또는 mRNA로부터 생산된 변이체 GPR156 mRNA 또는 cDNA의 수준을 특이적으로 검출하는데 이용될 수 있다. 일부 구체예에서, 핵산 분자는 GPR156 핵산의 영역을 증폭하기 위한 프라이머로서 이용될 수 있거나, 또는 핵산 분자는 예로서, 엄격한 조건 하에, 변이체 GPR156 유전자 좌위를 포함하는 핵산 분자 또는 mRNA로부터 생산된 변이체 GPR156 mRNA 또는 cDNA를 포함하는 핵산 분자에 특이적으로 혼성화하는 프로브로서 이용될 수 있다.
예로서, 핵산 염기서열결정, 핵산 혼성화 및 핵산 증폭을 비롯한 다양한 기술이 당해 분야에서 가용하다. 핵산 염기서열결정 기술의 예시적인 실례는 사슬 종결인자 (생어) 염기서열결정 및 염료 종결인자 염기서열결정을 포함하지만 이들에 한정되지 않는다.
다른 방법은 정제된 DNA, 증폭된 DNA 및 고정된 세포 제조물을 향해 지향된 표지화된 프라이머 또는 프로브 (형광 제자리 혼성화 (FISH))를 이용하는 것을 비롯하여, 염기서열결정 이외의 핵산 혼성화 방법을 수반한다. 일부 방법에서, 표적 핵산은 검출에 앞서 또는 검출과 동시에 증폭될 수 있다. 핵산 증폭 기술의 예시적인 실례는 중합효소 연쇄 반응 (PCR), 리가아제 연쇄 반응 (LCR), 가닥 대체 증폭 (SDA) 및 핵산 서열 기초된 증폭 (NASBA)을 포함하지만 이들에 한정되지 않는다. 다른 방법은 리가아제 연쇄 반응, 가닥 대체 증폭 및 고온성 SDA (tSDA)를 포함하지만 이들에 한정되지 않는다.
예로서, 혼성화 보호 검정 (HPA), 실시간 증폭 과정의 정량적 평가, 그리고 표본 내에 초기에 존재하지만 실시간 증폭에 근거되지 않는 표적 서열의 양을 결정하는 것을 비롯하여, 임의의 방법이 비-증폭된 또는 증폭된 폴리뉴클레오티드를 검출하는데 이용될 수 있다.
서열 증폭을 반드시 필요로 하지는 않고, 그리고 예로서, 염색체 물질의 서던 (DNA:DNA) 블롯 혼성화, 제자리 혼성화 (ISH) 및 형광 제자리 혼성화 (FISH)의 공지된 방법에 근거되는, 핵산을 확인하기 위한 방법 역시 제공된다. 서던 블로팅은 특정한 핵산 서열을 검출하는데 이용될 수 있다. 이런 방법에서, 표본으로부터 추출되는 핵산은 단편화되고, 매트릭스 겔에서 전기이동적으로 분리되고, 그리고 막 필터로 이전된다. 필터 결합된 핵산은 관심되는 서열에 상보적인 표지화된 프로브와의 혼성화에 종속된다. 필터에 결합된 혼성화된 프로브가 검출된다. 임의의 이런 방법에서, 과정은 본원에서 설명되거나 또는 예시된 프로브 중에서 한 가지를 이용한 혼성화를 포함할 수 있다.
혼성화 기술에서, 프로브 또는 프라이머가 표적에 특이적으로 혼성화하도록 엄격한 조건이 이용될 수 있다. 일부 구체예에서, 폴리뉴클레오티드 프라이머 또는 프로브는 엄격한 조건 하에, 다른 서열 (가령, 상응하는 야생형 GPR156 좌위, 야생형 mRNA, 또는 야생형 cDNA)보다 표적 서열 (가령, 변이체 (가령, E533D 또는 E529D) GPR156 유전자 좌위, 변이체 (가령, E533D 또는 E529D) GPR156 mRNA, 또는 변이체 (가령, E533D 또는 E529D) GPR156 cDNA)에 예로서, 배경에 비하여 최소한 2배, 최소한 3배, 최소한 4배, 또는 배경에 비하여 10-배 이상을 비롯한 그 이상의 검출가능하게 더욱 큰 정도로 혼성화할 것이다. 일부 구체예에서, 폴리뉴클레오티드 프라이머 또는 프로브는 엄격한 조건 하에, 다른 서열보다 표적 서열에 최소한 2배의 검출가능하게 큰 정도로 혼성화할 것이다. 일부 구체예에서, 폴리뉴클레오티드 프라이머 또는 프로브는 엄격한 조건 하에, 다른 서열보다 표적 서열에 최소한 3배의 검출가능하게 큰 정도로 혼성화할 것이다. 일부 구체예에서, 폴리뉴클레오티드 프라이머 또는 프로브는 엄격한 조건 하에, 다른 서열보다 표적 서열에 최소한 4배의 검출가능하게 큰 정도로 혼성화할 것이다. 일부 구체예에서, 폴리뉴클레오티드 프라이머 또는 프로브는 엄격한 조건 하에, 다른 서열보다 표적 서열에 배경에 비하여 10배 이상의 검출가능하게 큰 정도로 혼성화할 것이다. 엄격한 조건은 서열-의존성이고 서로 다른 상황에서 상이할 것이다. 혼성화의 엄격함 및/또는 세척 조건을 제어함으로써, 프로브에 100% 상보적인 표적 서열이 확인될 수 있다 (상동성 탐침). 대안으로, 엄격함 조건은 더욱 낮은 정도의 동일성이 검출되도록, 서열에서 일부 부정합을 허용하도록 조정될 수 있다 (이종성 탐침).
DNA 혼성화를 증진하는 적절한 엄격함 조건, 예를 들면, 약 45℃에서 6X 염화나트륨/구연산나트륨 (SSC), 그 이후에 50℃에서 2X SSC의 세척은 알려져 있거나, 또는 Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (1989), 6.3.1-6.3.6에서 발견될 수 있다. 전형적으로, 혼성화 및 검출을 위한 엄격한 조건은 염 농도가 pH 7.0 내지 8.3에서 약 1.5 M Na 이온보다 적고, 전형적으로 약 0.01 내지 1.0 M Na 이온 농도 (또는 다른 염)이고, 그리고 온도가 짧은 프로브 (가령, 10 내지 50개 뉴클레오티드)의 경우에 최소한 약 30℃ 및 더욱 긴 프로브 (가령, 50개 이상의 뉴클레오티드)의 경우에 최소한 약 60℃인 것들일 것이다. 엄격한 조건은 또한, 불안정화 작용제, 예를 들면, 포름아미드의 첨가로 달성될 수 있다. 예시적인 낮은 엄격함 조건은 37℃에서 30 내지 35% 포름아미드, 1 M NaCl, 1% SDS (황산도데실나트륨)의 완충액으로 혼성화, 그리고 50 내지 55℃에서 1X 내지 2X SSC (20X SSC = 3.0 M NaCl/0.3 M 구연산삼나트륨)에서 세척을 포함한다. 예시적인 중간 엄격함 조건은 37℃에서 40 내지 45% 포름아미드, 1.0 M NaCl, 1% SDS에서 혼성화, 그리고 55 내지 60℃에서 0.5X 내지 1X SSC에서 세척을 포함한다. 예시적인 높은 엄격함 조건은 37℃에서 50% 포름아미드, 1 M NaCl, 1% SDS에서 혼성화, 그리고 60 내지 65℃에서 0.1X SSC에서 세척을 포함한다. 임의선택적으로, 세척 완충액은 약 0.1% 내지 약 1% SDS를 포함할 수 있다. 혼성화의 지속 기간은 일반적으로, 약 24 시간보다 적고, 통상적으로 약 4 내지 약 12 시간이다. 세척 시간의 지속 기간은 최소한, 평형에 도달하는데 충분한 기간일 것이다.
혼성화 반응에서, 특이성은 전형적으로, 혼성화후 세척의 함수인데, 결정적인 인자는 이온 강도 및 최종 세척 용액의 온도이다. DNA-DNA 하이브리드의 경우에, Tm은 Meinkoth and Wahl, Anal. Biochem., 1984, 138, 267-284의 방정식: Tm = 81.5℃ + 16.6 (로그 M) + 0.41 (% GC) - 0.61 (% 포름) - 500/L로부터 근사될 수 있다; 여기서 M은 일가 양이온의 몰 농도이고, %GC는 DNA 내에 구아노신 및 시토신 뉴클레오티드의 백분율이고, % 포름은 혼성화 용액에서 포름아미드의 백분율이고, 그리고 L은 염기쌍에서 하이브리드의 길이이다. Tm은 상보성 표적 서열의 50%가 완벽하게 정합된 프로브에 혼성화하는 온도 (규정된 이온 강도 및 pH 하에)이다. Tm은 각 1%의 부정합에 대해 약 1℃씩 감소된다; 따라서, Tm, 혼성화 및/또는 세척 조건은 원하는 동일성의 서열에 혼성화하도록 조정될 수 있다. 가령, ≥90% 동일성을 갖는 서열이 모색되면, Tm은 10℃ 감소될 수 있다. 일반적으로, 엄격한 조건은 규정된 이온 강도 및 pH에서 특정한 서열 및 이의 보체에 대한 열 융점 (Tm)보다 약 5℃ 낮도록 선별된다. 하지만, 심하게 엄격한 조건은 열 융점 (Tm)보다 1℃, 2℃, 3℃ 또는 4℃ 낮은 온도에서 혼성화 및/또는 세척을 활용할 수 있다; 중간 정도로 엄격한 조건은 열 융점 (Tm)보다 6℃, 7℃, 8℃, 9℃ 또는 10℃ 낮은 온도에서 혼성화 및/또는 세척을 활용할 수 있다; 낮은 엄격함 조건은 열 융점 (Tm)보다 11℃, 12℃, 13℃, 14℃, 15℃ 또는 20℃ 낮은 온도에서 혼성화 및/또는 세척을 활용할 수 있다. 상기 방정식, 혼성화 및 세척 조성물, 그리고 원하는 Tm을 이용하여, 당업자는 혼성화의 엄격함 및/또는 세척 용액에서 변이가 내재적으로 설명된다고 이해할 것이다. 원하는 정도의 부정합이 45℃ (수성 용액) 또는 32℃ (포름아미드 용액)보다 낮은 Tm을 유발하면, 더욱 높은 온도가 이용될 수 있도록 SSC 농도를 증가시키는 것이 최적이다.
예로서, 단백질 염기서열결정 및 면역검정을 비롯하여, 생물학적 표본에서 변이체 GPR156 폴리펩티드의 존재를 검출하거나 또는 이의 수준을 정량하기 위한 방법 역시 제공된다. 일부 구체예에서, 인간 개체에서 GPR156 Glu533Asp (가령, 서열 번호:4 또는 서열 번호:5)의 존재를 검출하는 방법은 인간 개체로부터 생물학적 표본에서 GPR156 Glu533Asp (가령, 서열 번호:4 또는 서열 번호:5)의 존재를 결정하는 검정을 상기 생물학적 표본에서 수행하는 것을 포함한다.
단백질 염기서열결정 기술의 예시적인 무제한적 실례는 질량 분광분석법 및 에드만 분해를 포함하지만 이들에 한정되지 않는다. 면역검정의 예시적인 실례는 면역침전, 웨스턴 블롯, 면역조직화학, ELISA, 면역세포화학, 유세포분석법 및 면역-PCR을 포함하지만 이들에 한정되지 않는다. 다양한 공지된 기술 (가령, 비색정량, 형광, 화학발광 또는 방사성)을 이용하여 검출가능하게 표지화된 다중클론 또는 단일클론 항체는 면역검정에서 이용에 적합하다.
본 발명은 또한, 인간 개체에서 단극성 우울증을 진단하거나 또는 단극성 우울증의 위험을 검출하기 위한 방법을 제공하는데, 이들 방법은 인간 개체로부터 획득된 GPR156 단백질을 인코딩하는 핵산 분자에서 변경을 검출하고, 여기서 변경은 서열 번호:4에 따른 GPR156 단백질에서 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하고; 그리고 개체가 단극성 우울증의 하나 또는 그 이상의 증상을 비롯하여 우울증의 하나 또는 그 이상의 증상을 앓으면 인간 개체를 단극성 우울증을 앓는 것으로 진단하거나, 또는 개체가 우울증의 하나 또는 그 이상의 증상을 앓지 않으면 인간 개체를 단극성 우울증의 위험에 처해있는 것으로 진단하는 것을 포함한다. 일부 구체예에서, 인간 개체는 이런 진단이 필요하다. 일부 구체예에서, 인간 개체는 단극성 우울증으로 진단된 친척이 있을 수 있다. 변경은 서열 번호:13에 따른 위치 1599에 상응하는 위치에서 G로부터 T (또는 U) 또는 C로의 변화를 포함할 수 있다. 일부 구체예에서, 변경은 GPR156 단백질에서 위치 533에 상응하는 위치를 인코딩하는 코돈의 서열을 GAT (또는 GAU)로 변화시킨다. 일부 구체예에서, 변경은 GPR156 단백질에서 위치 533에 상응하는 위치를 인코딩하는 코돈의 서열을 GAC로 변화시킨다.
American Psychiatric Association, Washington D.C., 2013에 의해 공개된 정신 장애 진단 및 통계 편람 - 다섯 번째 판 (DSM-V)은 미국에서 정신 건강 전문가들의 일차 진단 참고문헌이다. DSM-V에 따르면, 단극성 우울증은 주요 우울 장애, 기분저하 장애, 혼합형 우울 장애, 우울한 기분을 동반하는 적응 장애, 그리고 달리 지정되지 않은 우울증 (NOS)으로 구성된다. 우울증에 대한 DSMIV 기준은 2 주 또는 그 이상 동안, 다음으로부터 5가지 또는 그 이상의 증상이다: i) 거의 매일 하루 중 대부분 동안 우울한 기분을 느낌; ii) 모든 또는 거의 모든 활동에서 현저하게 줄어든 관심 또는 즐거움; iii) 유의미한 체중 감소 또는 감소된 식욕; iv) 불면증 또는 과다수면증; v) 정신운동 초조 또는 지연; vi) 피로 또는 기력 상실; vii) 무가치한 느낌 또는 과도한 죄책감; viii) 줄어든 사고 또는 집중 능력 또는 우유부단; 그리고 ix) 죽음에 관한 정기적인 생각. 기분저하 장애에 대한 DSMIV 기준은 최소한 2 년 동안, 그렇지 않은 날보다 더욱 많은 날 동안, 이들 날들의 대부분 동안 우울한 기분에 의해 전시되는, 우울증의 압도적이지만 만성적인 상태에 의해 특징된다. 이러한 장애를 겪는 사람은 다음의 증상 중에서 2가지 또는 그 이상을 경험하지 않은 기간이 2 개월을 넘지 않을 것이다: i) 불량한 식욕 또는 과식; ii) 불면증 또는 과다수면증; iii) 낮은 기력 또는 피로; iv) 낮은 자존감; v) 집중하기 어렵거나 또는 결정하기 어려움; 그리고 vi) 절망감.
본 발명은 또한, 인간 개체에서 불안 장애를 진단하거나 또는 불안 장애의 위험을 검출하기 위한 방법을 제공하는데, 이들 방법은 인간 개체로부터 획득된 GPR156 단백질을 인코딩하는 핵산 분자에서 변경을 검출하고, 여기서 변경은 서열 번호:4에 따른 GPR156 단백질에서 위치 533에 상응하는 위치에서 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하고; 그리고 개체가 임상적 신경정신병적 불안 장애의 하나 또는 그 이상의 증상을 비롯하여 불안 장애의 하나 또는 그 이상의 증상을 앓으면 인간 개체를 불안 장애를 앓는 것으로 진단하거나, 또는 개체가 불안 장애의 하나 또는 그 이상의 증상을 앓지 않으면 인간 개체를 불안 장애의 위험에 처해있는 것으로 진단하는 것을 포함한다. 일부 구체예에서, 인간 개체는 이런 진단이 필요하다. 일부 구체예에서, 인간 개체는 불안 장애로 진단된 친척이 있을 수 있다. 변경은 서열 번호:13에 따른 위치 1599에 상응하는 위치에서 G로부터 T (또는 U) 또는 C로의 변화를 포함할 수 있다. 일부 구체예에서, 변경은 GPR156 단백질에서 위치 533에 상응하는 위치를 인코딩하는 코돈의 서열을 GAT (또는 GAU)로 변화시킨다. 일부 구체예에서, 변경은 GPR156 단백질에서 위치 533에 상응하는 위치를 인코딩하는 코돈의 서열을 GAC로 변화시킨다. 일부 구체예에서, 불안 장애는 임상적 신경정신병적 불안 장애이다.
불안 장애의 생리학적 증상은 근육 긴장, 심장 심계항진, 발한, 현기증 및 숨가쁨을 포함하지만 이들에 한정되지 않는다. 감정적 증상은 안절부절, 임박한 종말의 예감, 죽음 불안, 당혹 또는 굴욕의 불안, 그리고 끔찍한 일이 일어날 것 같은 불안을 포함하지만 이들에 한정되지 않는다.
일부 구체예에서, 이들 방법은 개체로부터 획득된 생물학적 표본으로부터 획득된 mRNA로부터 획득된 변이체 GPR156 유전체 DNA, mRNA 또는 cDNA의 존재를 검출하는 것을 포함한다. 개체군 내에 유전자 서열 및 이런 유전자에 의해 인코딩된 mRNA는 다형성, 예를 들면, 단일 뉴클레오티드 다형성 (SNPs)으로 인해 변할 수 있는 것으로 이해된다. GPR156 유전자, mRNA, cDNA 및 폴리펩티드에 대해 본원에서 제공된 서열은 단지 예시적인 서열이고, 그리고 GPR156 단백질 내에 위치 533 (서열 번호:4에 따른)/529 (서열 번호:5에 따른)에 상응하는 위치에서 아스파르트산을 인코딩하는 대립유전자 이외에 GPR156 대립유전자를 비롯한 다른 이런 서열 역시 가능하다.
일부 구체예에서, 검출하는 단계는 GPR156 단백질을 인코딩하는 핵산 분자의 최소한 일부를 염기서열결정하는 것을 포함하고, 여기서 염기서열결정된 핵산 분자는 GPR156 단백질의 서열 번호:4에 따른 위치 533 또는 서열 번호:5에 따른 위치 529에 상응하는 위치를 포함하는 아미노산 서열을 인코딩한다. 본원에서 개시된 핵산 분자 (가령, 유전체 DNA, mRNA 또는 cDNA) 중에서 한 가지가 염기서열결정될 수 있다. 일부 구체예에서, 검출하는 단계는 전체 핵산 분자를 염기서열결정하는 것을 포함한다.
일부 구체예에서, 검출하는 단계는 GPR156 단백질을 인코딩하는 핵산 분자의 최소한 일부를 증폭하고, 여기서 증폭된 핵산 분자는 서열 번호:4에 따른 위치 533 (및/또는 서열 번호:5에 따른 위치 529)에 상응하는 위치를 포함하는 아미노산 서열을 인코딩하고; 상기 핵산 분자를 검출가능한 표지로 표지화하고; 상기 표지화된 핵산을 프로브를 포함하는 지지체와 접촉시키고, 여기서 상기 프로브는 엄격한 조건 하에, 서열 번호:4에 따른 위치 533 (및/또는 서열 번호:5에 따른 위치 529)에 상응하는 위치에서 아스파르트산을 인코딩하는 핵산 서열에 혼성화하는 핵산 서열을 포함하고; 그리고 상기 검출가능한 표지를 검출하는 것을 포함한다. 본원에서 개시된 핵산 분자 중에서 한 가지가 증폭될 수 있다. 가령, 본원에서 개시된 유전체 DNA, cDNA 또는 mRNA 분자 중에서 한 가지가 증폭될 수 있다. 일부 구체예에서, 핵산 분자는 mRNA이고, 그리고 상기 방법은 증폭 단계에 앞서 mRNA를 cDNA로 역전사하는 것을 더욱 포함한다.
일부 구체예에서, 검출하는 단계는 핵산 분자를 검출가능한 표지를 포함하는 프로브와 접촉시키고, 여기서 상기 프로브는 엄격한 조건 하에, 서열 번호:4에 따른 위치 533 (및/또는 서열 번호:5에 따른 위치 529)에 상응하는 위치에서 아스파르트산을 포함하는 아미노산 서열을 인코딩하는 핵산 서열에 혼성화하는 핵산 서열을 포함하고, 그리고 상기 검출가능한 표지를 검출하는 것을 포함한다. 일부 구체예에서, 핵산 분자는 검출이 제자리 혼성화 기술에 따라서 이루어지도록, 인간 개체로부터 획득된 세포 내에 존재한다.
일부 구체예에서, 검출하는 단계는 핵산 분자를 대립유전자-특이적 프라이머와 접촉시키고, 그리고 대립유전자-특이적 PCR 기술을 이용하여 핵산 분자를 증폭하는 것을 포함한다. 대립유전자-특이적 프라이머는 본원에서 설명된 임의의 이런 프라이머일 수 있고, 그리고 서열 번호:4에 따른 위치 533 및/또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩하는 GPR156의 대립유전자에 특이적일 수 있다.
본원에서 개시된 방법에서 이용될 수 있는 다른 검정은 예로서, 역전사 중합효소 연쇄 반응 (RT-PCR) 또는 정량적 RT-PCR (qRT-PCR)을 포함한다. 본원에서 개시된 방법에서 이용될 수 있는 또 다른 검정은 예로서, RNA 염기서열결정 (RNA-Seq), 그 이후에 생물학적 표본에서 변이체 mRNA 또는 cDNA의 존재 및 양의 결정을 포함한다.
본 발명은 또한, 단극성 우울증을 앓거나 또는 단극성 우울증이 발달할 위험에 처해있는 인간 개체를 확인하기 위한 방법을 제공한다. 이들 방법은 일반적으로, 개체로부터 획득된 표본에서 GPR156 단백질 내에 E533D 변이의 존재 또는 부재; 및/또는 GPR156 단백질 내에 E533D 변이를 인코딩하는 돌연변이를 포함하는 핵산 분자의 존재 또는 부재를 결정하는 것을 포함한다. GPR156 단백질 내에 E533D 변이의 존재 및/또는 E533D 변이를 인코딩하는 핵산 분자의 존재는 개체가 단극성 우울증을 앓거나 또는 단극성 우울증이 발달할 위험에 처해있다는 것을 지시한다. 상기 방법은 시험관내, 원지, 또는 생체내에서 실행될 수 있다.
본 발명은 또한, 불안 장애를 앓거나 또는 불안 장애가 발달할 위험에 처해있는 인간 개체를 확인하기 위한 방법을 제공한다. 이들 방법은 일반적으로, 개체로부터 획득된 표본에서 GPR156 단백질 내에 E533D 변이의 존재 또는 부재; 및/또는 GPR156 단백질 내에 E533D 변이를 인코딩하는 돌연변이를 포함하는 핵산 분자의 존재 또는 부재를 결정하는 것을 포함한다. GPR156 단백질 내에 E533D 변이의 존재 및/또는 E533D 변이를 인코딩하는 핵산 분자의 존재는 개체가 불안 장애를 앓거나 또는 불안 장애가 발달할 위험에 처해있다는 것을 지시한다. 상기 방법은 시험관내, 원지, 또는 생체내에서 실행될 수 있다. 일부 구체예에서, 불안 장애는 임상적 신경정신병적 불안 장애이다.
상기 방법의 일부 구체예에서, 결정하는 단계는 GPR156 단백질을 인코딩하는 핵산 분자의 최소한 일부를 염기서열결정하는 것을 포함한다. 염기서열결정된 핵산 분자는 서열 번호:4에 따른 위치 533에 상응하는 위치를 포함하는 아미노산 서열을 인코딩할 수 있다. 결정하는 단계는 전체 GPR156 단백질을 인코딩하는 핵산 분자를 염기서열결정하는 것을 포함할 수 있다. 상기 방법의 일부 구체예에서, 결정하는 단계는 GPR156 단백질을 인코딩하는 핵산 분자의 최소한 일부를 증폭하고, 상기 핵산 분자를 검출가능한 표지로 표지화하고, 상기 표지화된 핵산을 프로브를 포함하는 지지체와 접촉시키고, 여기서 상기 프로브는 예로서, 엄격한 조건 하에, 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 핵산 서열에 특이적으로 혼성화하는 핵산 서열을 포함하고, 그리고 상기 검출가능한 표지를 검출하는 것을 포함한다. 증폭된 핵산 분자는 바람직하게는 서열 번호:4에 따른 위치 533에 상응하는 위치를 포함하는 아미노산 서열을 인코딩한다. 핵산이 mRNA를 포함하면, 상기 방법은 증폭 단계에 앞서 mRNA를 cDNA로 역전사하는 것을 더욱 포함할 수 있다. 일부 구체예에서, 결정하는 단계는 핵산 분자를 검출가능한 표지를 포함하는 프로브와 접촉시키고, 그리고 상기 검출가능한 표지를 검출하는 것을 포함한다. 프로브는 바람직하게는 예로서, 엄격한 조건 하에, 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 아미노산 서열을 인코딩하는 핵산 서열에 특이적으로 혼성화하는 핵산 서열을 포함한다. 핵산 분자는 인간 개체로부터 획득된 세포 내에 존재할 수 있다. 상기 방법의 일부로서, GPR156 단백질 내에서 E533D 변이는 핵산 서열 GAT에 의해 인코딩될 수 있거나, 또는 핵산 서열 GAC에 의해 인코딩될 수 있다.
본 발명은 또한, 인간 개체에서 단극성 우울증을 진단하거나 또는 단극성 우울증의 위험을 검출하기 위한 방법을 제공하는데, 이들 방법은 인간 개체로부터 획득된 변이체 GPR156 단백질, 예를 들면, 서열 번호:4 또는 서열 번호:5를 포함하는 단백질을 검출하고; 그리고 개체가 우울증의 하나 또는 그 이상의 증상을 앓으면 인간 개체를 단극성 우울증을 앓는 것으로 진단하거나, 또는 개체가 우울증의 하나 또는 그 이상의 증상을 앓지 않으면 인간 개체를 단극성 우울증의 위험에 처해있는 것으로 진단하는 것을 포함한다. 일부 구체예에서, 인간 개체는 이런 진단이 필요하다. 일부 구체예에서, 인간 개체는 단극성 우울증으로 진단된 친척이 있을 수 있다. 일부 구체예에서, 우울증 또는 단극성 우울증은 아동기 우울증 및/또는 불안이 아니다.
본 발명은 또한, 인간 개체에서 불안 장애를 진단하거나 또는 불안 장애의 위험을 검출하기 위한 방법을 제공하는데, 이들 방법은 인간 개체로부터 획득된 변이체 GPR156 단백질, 예를 들면, 서열 번호:4 또는 서열 번호:5를 포함하는 단백질을 검출하고; 그리고 개체가 불안 장애의 하나 또는 그 이상의 증상을 앓으면 인간 개체를 불안 장애를 앓는 것으로 진단하거나, 또는 개체가 불안 장애의 하나 또는 그 이상의 증상을 앓지 않으면 인간 개체를 불안 장애의 위험에 처해있는 것으로 진단하는 것을 포함한다. 일부 구체예에서, 인간 개체는 이런 진단이 필요하다. 일부 구체예에서, 인간 개체는 불안 장애로 진단된 친척이 있을 수 있다. 일부 구체예에서, 불안 장애는 임상적 신경정신병적 불안 장애이다.
일부 구체예에서, 상기 방법은 변경이 개체에서 검출되고 상기 개체가 단극성 우울증을 앓는 것으로 진단될 때, 상기 개체를 항우울제로 치료하는 것을 더욱 포함한다.
일부 구체예에서, 항우울제는 선택적 세로토닌 재흡수 저해제 (SSRI)이다. SSRIs의 적합한 실례는 시탈로프람 (Celexa®), 에스시탈로프람 (Lexapro®, Cipralex®), 파록세틴 (Paxil®, Seroxat®), 플루옥세틴 (Prozac®), 플루보사민 (Luvox®) 및 세르트랄린 (Zoloft®, Lustral®)을 포함하지만 이들에 한정되지 않는다.
일부 구체예에서, 항우울제는 세로토닌-노르에피네프린 재흡수 저해제 (SNRA)이다. SNRIs의 적합한 실례는 데스벤라파신 (Pristiq®), 둘록세틴 (Cymbalta®), 레보밀나시프란 (Fetzima®), 밀나시프란 (Ixel®, Savella®), 토페나센 (Elamol®, Tofacine®) 및 벤라팍신 (Effexor®)을 포함하지만 이들에 한정되지 않는다.
일부 구체예에서, 항우울제는 노르에피네프린 재흡수 저해제 (NRI)이다. NRIs의 적합한 실례는 레복세틴 (Edronax®), 빌록사진 (Vivalan®) 및 아토목세틴 (Strattera)을 포함하지만 이들에 한정되지 않는다.
일부 구체예에서, 항우울제는 리튬이다.
일부 구체예에서, 항우울제는 세로토닌 조절인자 및 자극기 (SMS)이다. SMSs의 적합한 실례는 빌라조돈 (Viibryd®) 및 보르티옥세틴 (Trintellix®)을 포함하지만 이들에 한정되지 않는다.
일부 구체예에서, 항우울제는 세로토닌 길항제 및 재흡수 저해제 (SARI)이다. SARIs의 적합한 실례는 에토페리돈 (Axiomin®, Etonin®), 네파조돈 (Nefadar®, Serzone®) 및 트라조돈 (Desyrel®)을 포함하지만 이들에 한정되지 않는다.
일부 구체예에서, 항우울제는 삼환상 항우울제 (TCA)이다. TCAs의 적합한 실례는 아미트립틸린 (Elavil®, Endep®), 아미트립틸리녹시드 (Amioxid®, Ambivalon®, Equilibrin®), 클로미프라민 (Anafranil®), 데시프라민 (Norpramin®, Pertofrane®), 디벤제핀 (Noveril®, Victoril®), 디메타크라인 (Istonil®), 도술레핀 (Prothiaden®), 독세핀 (Adapin®, Sinequan®), 이미프라민 (Tofranil®), 로페프라민 (Lomont®, Gamanil®), 멜리트라센 (Dixeran®, Melixeran®, Trausabun®), 니트록사제핀 (Sintamil®), 노르트립틸린 (Pamelor®, Aventyl®), 녹십틸린 (Agedal®, Elronon®, Nogedal®), 피포페진 (Azafen®/Azaphen®), 프로트립틸린 (Vivactil®) 및 트리미프라민 (Surmontil®)을 포함하지만 이들에 한정되지 않는다. 부트립틸린 (Evadyne®), 데메시프틸린 (Deparon®, Tinoran®), 이미프라미녹시드 (Imiprex®, Elepsin®), 이프린돌 (Prondol®, Galatur®, Tetran®), 메타프라민 (Timaxel®), 프로피제핀 (Depressin®, Vagran®) 및 퀴누프라민 (Kinupril®, Kevopril®) 또한 포함된다. 오피프라몰 (Insidon®) 및 티아넵틴 (Stablon®) 또한 포함된다.
일부 구체예에서, 항우울제는 사환 항우울제 (TeCA)이다. TeCAs의 적합한 실례는 아목사핀 (Asendin®), 마프로틸린 (Ludiomil®), 미안세린 (Bolvidon®, Norval®, Tolvon®), 미르타자핀 (Remeron®) 및 세팁틸린 (Tecipul®)을 포함하지만 이들에 한정되지 않는다.
일부 구체예에서, 항우울제는 모노아민 옥시다아제 저해제 (MAOI)이다. MAOIs의 적합한 실례는 이프로니아지드 (Marsilid®), 이소카르복사지드 (Marplan®), 페닐진 (Nardil®), 셀레길린 (Eldepryl®, Zelapar®, Emsam®), 트라닐시프로민 (Parnate®), 메트라린돌 (Inkazan®), 모클로베미드 (Aurorix®, Manerix®), 피를린돌 (Pirazidol®) 및 톨록사톤 (Humoryl®)을 포함하지만 이들에 한정되지 않는다. 다른 것들은 예로서, 벤목신 (Neuralex®), 카록사존 (Surodil®, Timostenil®), 이프로클로지드 (Sursum®), 메바나진 (Actomol®), 니알라미드 (Niamid®), 옥타목신 (Ximaol®), 페니프라진 (Catron®), 페녹시프로파진 (Drazine®), 피브히드라진 (Tersavid®), 사프라진 (Safra®), 에프로베미드 (Befol®) 및 미나프린 (Brantur®, Cantor®)을 포함한다.
일부 구체예에서, 항우울제는 비정형성 항정신병약이다. 비정형성 항정신병약의 적합한 실례는 아미술프리드 (Solian®), 루라시돈 (Latuda®) 및 퀘티아핀 (Seroquel®)을 포함하지만 이들에 한정되지 않는다.
일부 구체예에서, 항우울제는 아고멜라틴 (Valdoxan®), 비페멜레인 (Alnert®, Celeport®), 부프로피온 (Wellbutrin®), 케타민 (Ketalar®), 탄도스피론 (Sediel®), 또는 테닐록사진 (Lucelan®, Metatone®)이다.
일부 구체예에서, 상기 방법은 개체에서 변경이 검출되고 상기 개체가 불안 장애를 앓는 것으로 진단될 때, 상기 개체를 항불안성 작용제로 치료하는 것을 더욱 포함한다. 일부 구체예에서, 불안 장애는 임상적 신경정신병적 불안 장애이다
일부 구체예에서, 항불안성 작용제는 알프라졸람 (Xanax®), 브로마제팜 (Lectopam®, Lexotan®), 클로르디아제폭시드 (Librium®), 클로나제팜 (Klonopin®, Rivotril®), 클로라제페이트 (Tranxene®), 디아제팜 (Valium®), 플루라제팜 (Dalmane®), 로라제팜 (Ativan®), 옥사제팜 (Serax®, Serapax®), 테마제팜 (Restoril®), 트리아졸람 (Halcion®) 및 토프이소팜 (Emandaxin®, Grandaxin®)을 포함하지만 이들에 한정되지 않는 벤조디아제핀이다.
일부 구체예에서, 항불안성 작용제는 메프로바메이트 (Miltown®, Equanil®)을 포함하지만 이에 한정되지 않는 카바메이트이다.
일부 구체예에서, 항불안성 작용제는 히드록시진 (Atarax®), 클로르페니라민 (Chlor-Trimeton®) 및 디펜히드라민 (Benadryl®)을 포함하지만 이들에 한정되지 않는 항히스타민제이다.
일부 구체예에서, 항불안성 작용제는 부스피론 (Buspar®) 및 탄도스피론 (Sediel®)을 포함하지만 이들에 한정되지 않는 아자피론이다.
일부 구체예에서, 항불안성 작용제는 본원에서 설명된 바와 같은 SSRI, SNRI, TCA, TeCA, 또는 MAOI이다.
일부 구체예에서, 항불안성 작용제는 메비카르 (Mebicarum®), 파보모티졸 (Afobazole®), 셀란크, 브로만탄, 에목시핀, 프레가발린, 멘틸 이소발레르산염, 또는 멘틸 이소발레르산염 (Validol®)이다.
항우울제 또는 항불안성 작용제의 투여는 비경구, 정맥내, 경구, 피하, 동맥내, 두개내, 척수강내, 복막내, 국소, 비내, 또는 근육내를 포함하지만 이들에 한정되지 않는 임의의 적합한 루트에 의할 수 있다. 투여를 위한 제약학적 조성물은 바람직하게 무균이고, 실제적으로 등장성이고, GMP 조건 하에 제조된다. 제약학적 조성물은 단위 복용 형태 (다시 말하면, 단일 투여를 위한 용량)에서 제공될 수 있다. 제약학적 조성물은 하나 또는 그 이상의 생리학적으로 및 제약학적으로 허용되는 담체, 희석제, 부형제 또는 보조제를 이용하여 조제될 수 있다. 조제는 선택된 투여 루트에 의존한다. 용어 "제약학적으로 허용되는"은 담체, 희석제, 부형제 또는 보조제가 제제의 다른 성분과 양립하고 이의 수용자에게 실제적으로 유해하지 않다는 것을 의미한다.
본 발명은 또한, 인간 GPR156 단백질을 인코딩하는 유전자에서 변경을 포함하는 인간 개체에서 단극성 우울증의 치료에서 이용을 위한 항우울제를 제공하는데, 여기서 상기 변경은 서열 번호:4에 따른 위치 533 또는 서열 번호:4에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩한다. 본 발명은 인간 GPR156 단백질을 인코딩하는 유전자에서 변경을 포함하는 인간 개체에서 단극성 우울증의 치료를 위한 약제의 제조에서 이용을 위한 항우울제를 더욱 제공하는데, 여기서 상기 변경은 인간 GPR156 단백질에서 서열 번호:4에 따른 위치 533 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩한다. 일부 구체예에서, 상기 변경은 서열 번호:4에 따른 위치 533 또는 서열 번호:5에 따른 위치 529에 상응하는 위치를 인코딩하는 코돈의 서열을 GAT (또는 GAU)로 변화시킨다. 일부 구체예에서, 상기 변경은 서열 번호:4에 따른 위치 533 또는 서열 번호:5에 따른 위치 529에 상응하는 위치를 인코딩하는 코돈의 서열을 GAC로 변화시킨다. 일부 구체예에서, 항우울제는 선택적 세로토닌 재흡수 저해제, 세로토닌-노르에피네프린 재흡수 저해제, 또는 노르에피네프린 재흡수 저해제이다. 일부 구체예에서, 항우울제는 리튬이다.
인간 개체에서 단극성 우울증의 치료에서 이용을 위한 항우울제의 일부 구체예에서, 인간 개체는 GPR156 단백질 내에서 E533D 변이 및/또는 GPR156 단백질 내에서 E533D 변이를 인코딩하는 핵산 분자에 대해 양성으로 검사되었다. 일부 구체예에서, 치료는 인간 개체가 E533D 변이가 있는 GPR156 단백질 및/또는 E533D 변이가 있는 GPR156 단백질을 인코딩하는 핵산 분자를 갖는 지의 여부를 결정하는 단계를 포함한다. 일부 구체예에서, 인간 개체는 본원에서 설명되거나 또는 예시된 임의의 이런 방법을 비롯하여, 단극성 우울증을 앓거나 또는 단극성 우울증이 발달할 위험에 처해있는 인간 개체를 확인하기 위한 방법에 따라, 단극성 우울증을 앓거나 또는 단극성 우울증이 발달할 위험에 처해 있는 것으로 확인되었다. E533D 변이는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 유발하는 돌연변이를 지칭한다. 일부 구체예에서, GPR156 단백질 내에서 E533D 변이는 코돈 GAT에 의해 인코딩된다. 일부 구체예에서, GPR156 단백질 내에서 E533D 변이는 코돈 GAC에 의해 인코딩된다. 일부 구체예에서, 인간 개체에서 단극성 우울증의 치료에서 이용을 위한 항우울제는 선택적 세로토닌 재흡수 저해제, 세로토닌-노르에피네프린 재흡수 저해제, 또는 노르에피네프린 재흡수 저해제이다. 일부 구체예에서, 인간 개체에서 단극성 우울증의 치료에서 이용을 위한 항우울제는 리튬이다.
본 발명은 또한, 인간 GPR156 단백질을 인코딩하는 유전자에서 변경을 포함하는 인간 개체에서 불안 장애의 치료에서 이용을 위한 항불안성 작용제를 제공하는데, 여기서 상기 변경은 서열 번호:4에 따른 위치 533 또는 서열 번호:4에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩한다. 본 발명은 인간 GPR156 단백질을 인코딩하는 유전자에서 변경을 포함하는 인간 개체에서 불안 장애의 치료를 위한 약제의 제조에서 이용을 위한 항불안성 작용제를 더욱 제공하는데, 여기서 상기 변경은 인간 GPR156 단백질에서 서열 번호:4에 따른 위치 533 또는 서열 번호:5에 따른 위치 529에 상응하는 위치에서 아스파르트산을 인코딩한다. 일부 구체예에서, 상기 변경은 서열 번호:4에 따른 위치 533 또는 서열 번호:5에 따른 위치 529에 상응하는 위치를 인코딩하는 코돈의 서열을 GAT (또는 GAU)로 변화시킨다. 일부 구체예에서, 상기 변경은 서열 번호:4에 따른 위치 533 또는 서열 번호:5에 따른 위치 529에 상응하는 위치를 인코딩하는 코돈의 서열을 GAC로 변화시킨다. 일부 구체예에서, 항불안성 작용제는 벤조디아제핀, 카바메이트, 항히스타민제, 아자피론, SSRI, SNRI, TCA, TeCA, 또는 MAOI이다. 일부 구체예에서, 불안 장애는 임상적 신경정신병적 불안 장애이다.
인간 개체에서 불안 장애의 치료에서 이용을 위한 항불안성 작용제의 일부 구체예에서, 인간 개체는 GPR156 단백질 내에서 E533D 변이 및/또는 GPR156 단백질 내에서 E533D 변이를 인코딩하는 핵산 분자에 대해 양성으로 검사되었다. 일부 구체예에서, 치료는 인간 개체가 E533D 변이가 있는 GPR156 단백질 및/또는 E533D 변이가 있는 GPR156 단백질을 인코딩하는 핵산 분자를 갖는 지의 여부를 결정하는 단계를 포함한다. 일부 구체예에서, 인간 개체는 본원에서 설명되거나 또는 예시된 임의의 이런 방법을 비롯하여, 불안 장애를 앓거나 또는 불안 장애가 발달할 위험에 처해있는 인간 개체를 확인하기 위한 방법에 따라, 불안 장애를 앓거나 또는 불안 장애가 발달할 위험에 처해 있는 것으로 확인되었다. E533D 변이는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 유발하는 돌연변이를 지칭한다. 일부 구체예에서, GPR156 단백질 내에서 E533D 변이는 코돈 GAT에 의해 인코딩된다. 일부 구체예에서, GPR156 단백질 내에서 E533D 변이는 코돈 GAC에 의해 인코딩된다. 일부 구체예에서, 인간 개체에서 불안 장애의 치료에서 이용을 위한 항불안성 작용제는 벤조디아제핀, 카바메이트, 항히스타민제, 아자피론, SSRI, SNRI, TCA, TeCA, 또는 MAOI이다. 일부 구체예에서, 불안 장애는 임상적 신경정신병적 불안 장애이다.
본 발명은 또한, 단극성 우울증의 진단에서 또는 단극성 우울증이 발달할 위험의 진단에서 본원에서 개시된 변이체 GPR156 유전자, mRNA, cDNA, 폴리펩티드 및 혼성화 핵산 분자 중에서 한 가지의 용도를 제공한다.
본 발명은 또한, 불안 장애의 진단에서 또는 불안 장애가 발달할 위험의 진단에서 본원에서 개시된 변이체 GPR156 유전자, mRNA, cDNA, 폴리펩티드 및 혼성화 핵산 분자 중에서 한 가지의 용도를 제공한다. 일부 구체예에서, 불안 장애는 임상적 신경정신병적 불안 장애이다.
상기 또는 하기에서 인용된 모든 특허 문서, 웹사이트, 다른 간행물, 수탁 번호 등은 마치 각 개별 항목이 참조로서 편입되는 것으로 특정적으로 및 개별적으로 지시되는 것과 동일한 정도로 모든 점에서 전체적으로 참조로서 편입된다. 서열의 상이한 버전이 상이한 시점에서 수탁 번호와 연관되면, 본 출원의 유효 출원일에서 수탁 번호와 연관된 버전이 의미된다. 유효 출원일은 실제 출원일, 또는 적용가능하면, 수탁 번호를 참조하는 우선권 출원의 출원일 중에서 더욱 앞선 것을 의미한다. 유사하게, 간행물, 웹사이트 또는 기타 유사한 것의 상이한 버전이 상이한 시점에서 공개되면, 달리 지시되지 않으면 출원의 유효 출원일에서 가장 최근에 공개된 버전이 의미된다. 본 발명의 임의의 특질, 단계, 요소, 구체예 또는 양상은 달리 구체적으로 지시되지 않으면 임의의 다른 특질, 단계, 요소, 구체예 또는 양상과 조합으로 이용될 수 있다. 비록 본 발명이 명료함 및 이해를 위해 예시와 실례에 의하여 일부 상세하게 설명되긴 하지만, 일정한 변화와 변형이 첨부된 청구항의 범위 내에서 실시될 수 있다는 것은 명백할 것이다.
본원에서 언급된 뉴클레오티드 및 아미노산 서열은 뉴클레오티드 염기에 대한 표준 문자 약어 및 아미노산에 대한 1 문자 코드를 이용하여 도시된다. 뉴클레오티드 서열은 서열의 5' 단부에서 시작하고 3' 단부로 진행하는 (다시 말하면, 각 라인에서 왼쪽에서 오른쪽으로) 표준 규약을 따른다. 각 뉴클레오티드 서열의 단지 하나의 가닥만 도시되지만, 상보성 가닥이 전시된 가닥에 대한 임의의 참조에 의해 포함되는 것으로 이해된다. 아미노산 서열은 서열의 아미노 말단에서 시작하고 카르복시 말단으로 진행하는 (다시 말하면, 각 라인에서 왼쪽에서 오른쪽으로) 표준 규약을 따른다.
다음 실시예는 구체예를 더욱 상세하게 설명하기 위해 제공된다. 이들은 청구된 구체예를 한정하는 것이 아닌 예시하는 것으로 의도된다.
실시예
다음 실시예는 본원에서 청구된 화합물, 조성물, 물품, 장치 및/또는 방법이 어떻게 만들어지고 평가되는 지에 관한 완전한 개시와 설명을 당업자에게 제공하기 위해 제안되고, 그리고 전적으로 예시하는 것으로 의도되고 발명자들이 그들의 발명으로서 간주하는 것의 범위를 한정하는 것으로 의도되지 않는다. 숫자 (가령, 양, 온도 등)에 대하여 정확도를 담보하기 위한 노력이 이루어졌지만, 일부 오차와 편차가 고려되어야 한다. 달리 지시되지 않으면, 분율은 중량부이고, 온도는 ℃이거나 또는 주위 온도이고, 그리고 압력은 대기압이거나 또는 이에 가깝다.
실시예 1: 환자 모집 및 표현형분석
전체 진유전체 염기서열결정은 단극성 우울증의 유전적 평가에 대해 확인된 메노파 교도 혈통의 가족에서 수행되었다. 이러한 가계에서 개체는 부가적으로, DSM-5에 대한 구조화 임상 면접 (SCID-5)을 이용하여 신경정신병 팀에 의해 계통적으로 평가되었다. 이러한 반-구조화 면담은 숙련된 정신 건강 전문가에 의해 시행되고, 그리고 DSM-5 장애의 체계적이고 정확한 진단을 담보하도록 설계된다. 상기 면담은 개체 및 그들의 친척이 주요 우울증, 범불안 장애, 그리고 임의의 다른 동시이환 정신 질환에 대한 기준에 부합하는 지를 결정하는데 이용되었다. 면담은 전형적으로, 개체에서 수행하는데 1 내지 2 시간이 소요되었다. 면담에 더하여, 개체의 서면 동의를 얻어 개체의 진료 기록, 치료 제공자 및 밀접한 지인으로부터 진단을 확증하기 위해 부수적인 정보가 수집되었다. 총 50명의 개체를 포괄하는 이러한 큰 가계에서 모든 가용한 영향을 받은 가족 구성원 및 영향을 받지 않은 가족 구성원의 진유전체가 염기서열결정되었다.
실시예 2: 유전체 표본
유전체 DNA는 말초혈 표본으로부터 추출되고, 전체 진유전체 염기서열결정을 위해 Regeneron Genetics Center (RGC)로 이전되고, 그리고 -80℃에서 자동화 바이오뱅크에서 보관되었다. 염기서열결정하기 위한 목적으로 적절한 DNA 양과 품질을 담보하기 위해 형광-기초된 정량이 수행되었다.
1 μg의 DNA가 150개 염기쌍의 평균 단편 길이로 전단되고 (Covaris LE220), 그리고 Kapa Biosystems로부터 맞춤 시약 키트로 진유전체 캡처를 위해 준비되었다. 표본은 NimbleGen SeqCap VCRome 2.1 또는 Integrated DNA Technologies xGen 진유전체 표적 설계를 이용하여 캡처되었다. 표본은 바코드화되고, 모아지고, 그리고 v4 화학으로 Illumina HiSeq 2500에서 75 bp 쌍 단부 염기서열결정을 이용하여 다중화되거나 염기서열결정되었다. 캡처된 단편은 20x 또는 그 이상 적용범위에서 커버된 표적 염기 중에서 최소한 85%를 달성하기 위해 염기서열결정되었다. 염기서열결정 이후에, 데이터는 표본-수준 데이터 생산 및 분석을 위한 표준 도구를 실행하기 위해 DNAnexus 및 AWS를 이용하는, RGC에서 개발된 클라우드-기초된 파이프라인을 이용하여 처리되었다. 간단히 말하면, 서열 데이터는 Illumina의 CASAVA 소프트웨어를 이용하여 산출되고 역다중화되었다. 서열 리드는 지도화되고, 그리고 BWA-mem을 이용하여 GRCh37/hg19 인간 유전체 참고 어셈블리에 맞춰 정렬되었다. 정렬 후, 중복 리드는 Picard 도구를 이용하여 표시되고 플래그 지정되었고, 그리고 삽입-결실은 변이 호출 품질을 향상시키기 위해 GATK를 이용하여 재정렬되었다. SNP 및 삽입-결실 (INDEL) 변이체 및 유전자형은 GATK의 HaplotypeCaller를 이용하여 호출되었고, 그리고 GATK로부터 변이 품질 점수 재측정 (VQSR)이 전반적인 변이 품질 점수를 주해하는데 적용되었다. 캡처 성과, 정렬 성과 및 변이 호출을 평가하기 위해, 각 표본에 대한 염기서열결정 및 데이터 품질 계량 통계가 캡처되었다.
실시예 3: 유전체학 데이터 분석
최소 리드 깊이 (>10), 유전자형 품질 (>30) 및 대립유전자 균형 (>15%)을 위한 표준 품질-제어 필터가 변이체를 호출하는데 적용되었다. 통과 변이체는 RGC 개발된 주해 및 분석 파이프라인을 이용하여, 그들의 잠재적인 기능적 효과 (유의한, 비유의한, 스플라이싱, 프레임시프트, 또는 비프레임시프트 변이체인 지에 상관없이)에 근거하여 분류되고 주해되었다. 가족 관계는 PRIMUS (Staples et al., Amer. J. Human Genet., 2014, 95, 553-564) 및 이러한 가족에 대한 보고된 가계와의 교차-참조를 이용하여 코호트에서 관련성 및 관계를 추론하기 위해, 유전적 데이터로부터 유전적 일치도 (IBD) 유래된 메트릭스를 통해 실증되었다.
보고된 가족력을 고려하여 상염색체 우성 유전질환 패턴 하에 후보 질환 유전자를 확인하기 위해 가계-기초된 변이체 분석 및 분리가 수행되었다. 일차 분석은 장애의 불완전 침투율, 개시 연령, 또는 질환의 증후성 표현을 촉발할 수 있는 환경 인자에 잠재적 노출에 의해 제공된 잠재적 교란요인을 감소시키기 위해, 염기서열결정하는데 가용한 많은 정보가 있는 영향을 받은 개체를 이용하여 수행되었다. 모든 영향을 받은 개체 사이에서 공유된 변이체는 차후에, 주해되고, 그리고 통상적인 다형성 및 높은 빈도, 아마도 양성 변이체를 걸러 내기 위해 모집단 대조 데이터베이스, 예를 들면, dbSNP, 1000 Genomes Project, NHLBI Exome Sequencing Project, Exome Aggregation Consortium Database (ExAc) 및 내부 RGC 데이터베이스에서 그들의 관찰된 빈도에 의해 필터링되었다. 변이체의 기능적 효과의 생물정보학적 예측을 위한 알고리즘, 예를 들면, LRT, Poly-phen2, SIFT, CADD 및 Mutation Taster은 복수 종류 정렬 (다시 말하면, GERP, PhastCons, PhyloP)에 근거된 보존 점수와 함께, 변이체의 주해 과정의 일부로서 통합되고, 그리고 확인된 후보 변이체의 잠재력 유해성에 관한 정보를 통지하는데 이용되었다.
단일 희귀 변이체가 이러한 가계의 영향을 받은 가족 구성원에서 단극성 우울증의 표현형으로 분리하는 유전자 GPR156 (hg19.g.chr3:119886725(C>A); c.1599G>T; p.Glu533Asp, p.E533D)에서 확인되었다. 일차 분석에 포함되지 않았지만 p.E533D 변이체를 보유하는 추가 가족 구성원이 불안 장애의 확증된 진단을 받았다. 이러한 가족에서 우울증 또는 불안 장애 표현형으로 분리하는 다른 가능한 변이체를 배제하기 위해, 단일 포인트 진유전체-너비 및 다중 포인트 유전체-너비 연관 분석이 공개된 MERLIN 알고리즘 (Abecasis et al., Nat. Genet., 2002, 30)에 근거된 맞춤형 RGC 개발된 파이프라인을 이용하여 수행되었다. 간단히 말하면, SNP 칩 및 진유전체 유래된 유전자형의 파라미터 연관 분석이 MERLIN (csg.sph.umich.edu/ abecasis/merlin/index.html)을 이용하여 수행되었다. PLINK 형식화된 유전자형은 최소한 한 명의 비-창시자에서 존재하는 단일 뉴클레오티드 변이체 (SNVs)에 한정되었다. 대립유전자 빈도는 창시자 및 가계의 다른 관련 없는 구성원에서 추정되었다. 유전자 데이터가 없는 개체는 누락/더미 유전자형이 배정되었다. fcGENE (sourceforge.net/projects/fcgene/)가 PLINK 형식 유전자형을 MERLIN 형식화된 ped 파일로 전환하는데 이용되었다. 연관 분석에 필요한 추가 파일 (.dat 및 .map)은 맞춤형 스크립트를 이용하여 제조되었다. 가계 구조는 Pedstats (csg.sph.umich.edu/abecasis/pedstats/index.html)를 이용하여 검증되었다. 칩 데이터의 연관 분석은 재조합에 관한 추정 없이, 유전자형 사이에 단계별 또는 격자 간격을 이용하여 실행되었다. 단일-포인트 연쇄가 진유전체 기초된 유전자형을 분석하는데 이용되었다. 모든 분석의 경우에, 불완전 침투율 모형은 대략 0.01%의 질환 대립유전자 빈도에서 추정되었다 (0.0001, 0.75, 1).
진유전체-너비 및 유전체-너비 분석 둘 모두의 경우에, 2.98의 최대 LOD 점수에 도달하고 인간 염색체 3에서 14.4 메가베이스 (Mb) 영역을 확장하는 연쇄의 단일 피크가 이러한 가계에서 확인되었다. 이러한 연쇄 영역 내에 GPR156 유전자가 위치되고, 그리고 초기 희귀-변이체 가족-기초된 분리 분석을 통해 확인된 후보 변이체 (c.1599G>T, p.Glu533Asp)는 2.56의 단일 마커 LOD 점수를 달성하였다.
본원에서 증명된 바와 같이, 이들 유전자 분석은 GPR156이 단극성 우울증 및 불안 장애에 대한 증가된 가족 감수성과 연관된 유전자라는 것을 지시한다.
추가적으로, 야생형 및 돌연변이체 E533D 서열을 포함하는 뉴클레오티드 단편이 추가 분석을 위한 야생형 및 변이체 E533D GPR156 구조체를 획득하기 위해 벡터 내로 하위클로닝되었다 (도면 1 및 2를 참조한다).
실시예 4: 검출
개체에서 일정한 유전자 변이체의 존재는 개체가 단극성 우울증을 앓거나 또는 단극성 우울증이 발달할 증가된 위험을 갖는다는 것을 지시할 수 있다. 표본, 예를 들면, 혈액 표본이 개체로부터 획득될 수 있다. 핵산은 통상적인 핵산 추출 키트를 이용하여 표본으로부터 단리될 수 있다. 개체로부터 획득된 표본으로부터 핵산을 단리한 후, 핵산은 유전자 변이체가 존재하는 지를 결정하기 위해 염기서열결정된다. 핵산의 서열은 대조 서열 (야생형 서열)과 비교될 수 있다. 개체로부터 획득된 표본으로부터 획득된 핵산 및 대조 서열 사이에 차이를 발견하는 것은 유전자 변이체의 존재를 지시한다. 이들 단계는 상기 실시예에서 및 본 명세서 전역에서 설명된 바와 같이 수행될 수 있다. 하나 또는 그 이상의 유전자 변이체의 존재는 단극성 우울증을 앓거나 또는 단극성 우울증이 발달할 개체의 증가된 위험을 지시한다.
본 출원에서 인용된 각 참고문헌 (학술지 논문, U.S. 및 비-U.S. 특허, 특허 출원 공개, 국제 특허 출원 공개, 유전자 은행 수탁 번호 등을 포함하지만 이들에 한정되지 않음)은 본원에서 전체적으로 참조로서 편입된다.
SEQUENCE LISTING
<110> Regeneron Pharmaceuticals, Inc.
<120> GPR156 Variants And Uses Thereof
<130> 189238.00702 WO
<150> 62/367,973
<151> 2016-07-28
<160> 42
<170> PatentIn version 3.5
<210> 1
<211> 814
<212> PRT
<213> Homo sapien
<220>
<223> Wild type GPR156 isoform 1 protein
<220>
<221> MOD_RES
<222> (516)..(516)
<223> Xaa is glutamic acid or aspartic acid
<400> 1
Met Glu Pro Glu Ile Asn Cys Ser Glu Leu Cys Asp Ser Phe Pro Gly
1 5 10 15
Gln Glu Leu Asp Arg Arg Pro Leu His Asp Leu Cys Lys Thr Thr Ile
20 25 30
Thr Ser Ser His His Ser Ser Lys Thr Ile Ser Ser Leu Ser Pro Val
35 40 45
Leu Leu Gly Ile Val Trp Thr Phe Leu Ser Cys Gly Leu Leu Leu Ile
50 55 60
Leu Phe Phe Leu Ala Phe Thr Ile His Cys Arg Lys Asn Arg Ile Val
65 70 75 80
Lys Met Ser Ser Pro Asn Leu Asn Ile Val Thr Leu Leu Gly Ser Cys
85 90 95
Leu Thr Tyr Ser Ser Ala Tyr Leu Phe Gly Ile Gln Asp Val Leu Val
100 105 110
Gly Ser Ser Met Glu Thr Leu Ile Gln Thr Arg Leu Ser Met Leu Cys
115 120 125
Ile Gly Thr Ser Leu Val Phe Gly Pro Ile Leu Gly Lys Ser Trp Arg
130 135 140
Leu Tyr Lys Val Phe Thr Gln Arg Val Pro Asp Lys Arg Val Ile Ile
145 150 155 160
Lys Asp Leu Gln Leu Leu Gly Leu Val Ala Ala Leu Leu Met Ala Asp
165 170 175
Val Ile Leu Leu Met Thr Trp Val Leu Thr Asp Pro Ile Gln Cys Leu
180 185 190
Gln Ile Leu Ser Val Ser Met Thr Val Thr Gly Lys Asp Val Ser Cys
195 200 205
Thr Ser Thr Ser Thr His Phe Cys Ala Ser Arg Tyr Ser Asp Val Trp
210 215 220
Ile Ala Leu Ile Trp Gly Cys Lys Gly Leu Leu Leu Leu Tyr Gly Ala
225 230 235 240
Tyr Leu Ala Gly Leu Thr Gly His Val Ser Ser Pro Pro Val Asn Gln
245 250 255
Ser Leu Thr Ile Met Val Gly Val Asn Leu Leu Val Leu Ala Ala Gly
260 265 270
Leu Leu Phe Val Val Thr Arg Tyr Leu His Ser Trp Pro Asn Leu Val
275 280 285
Phe Gly Leu Thr Ser Gly Gly Ile Phe Val Cys Thr Thr Thr Ile Asn
290 295 300
Cys Phe Ile Phe Ile Pro Gln Leu Lys Gln Trp Lys Ala Phe Glu Glu
305 310 315 320
Glu Asn Gln Thr Ile Arg Arg Met Ala Lys Tyr Phe Ser Thr Pro Asn
325 330 335
Lys Ser Phe His Thr Gln Tyr Gly Glu Glu Glu Asn Cys His Pro Arg
340 345 350
Gly Glu Lys Ser Ser Met Glu Arg Leu Leu Thr Glu Lys Asn Ala Val
355 360 365
Ile Glu Ser Leu Gln Glu Gln Val Asn Asn Ala Lys Glu Lys Ile Val
370 375 380
Arg Leu Met Ser Ala Glu Cys Thr Tyr Asp Leu Pro Glu Gly Ala Ala
385 390 395 400
Pro Pro Ala Ser Ser Pro Asn Lys Asp Val Gln Ala Val Ala Ser Val
405 410 415
His Thr Leu Ala Ala Ala Gln Gly Pro Ser Gly His Leu Ser Asp Phe
420 425 430
Gln Asn Asp Pro Gly Met Ala Ala Arg Asp Ser Gln Cys Thr Ser Gly
435 440 445
Pro Ser Ser Tyr Ala Gln Ser Leu Glu Gly Pro Gly Lys Asp Ser Ser
450 455 460
Phe Ser Pro Gly Lys Glu Glu Lys Ile Ser Asp Ser Lys Asp Phe Ser
465 470 475 480
Asp His Leu Asp Ser Gly Cys Ser Gln Lys Pro Trp Thr Glu Gln Ser
485 490 495
Leu Gly Pro Glu Arg Gly Asp Gln Val Pro Met Asn Pro Ser Gln Ser
500 505 510
Leu Leu Pro Xaa Arg Gly Gly Ser Asp Pro Gln Arg Gln Arg His Leu
515 520 525
Glu Asn Ser Glu Glu Pro Pro Glu Arg Arg Ser Arg Val Ser Ser Val
530 535 540
Ile Arg Glu Lys Leu Gln Glu Val Leu Gln Asp Leu Gly Leu Gly Pro
545 550 555 560
Glu Ala Ser Leu Ser Thr Ala Pro Ser Cys His Gln Gln Thr Trp Lys
565 570 575
Asn Ser Ala Ala Phe Ser Pro Gln Lys Met Pro Leu Ser Lys Glu Leu
580 585 590
Gly Phe Ser Pro Tyr Met Val Arg Arg Arg Arg Ala Ala Gln Arg Ala
595 600 605
Arg Ser His Phe Pro Gly Ser Ala Pro Ser Ser Val Gly His Arg Ala
610 615 620
Asn Arg Thr Val Pro Gly Ala His Ser Arg Leu His Val Gln Asn Gly
625 630 635 640
Asp Ser Pro Ser Leu Ala Pro Gln Thr Thr Asp Ser Arg Val Arg Arg
645 650 655
Pro Ser Ser Arg Lys Pro Ser Leu Pro Ser Asp Pro Gln Asp Arg Pro
660 665 670
Gly Thr Leu Glu Gly Ser Lys Gln Ser Gln Thr Glu Pro Glu Gly Ala
675 680 685
Arg Gly Ser Lys Ala Ala Phe Leu Arg Gln Pro Ser Gly Ser Gly Arg
690 695 700
Ala Pro Ser Pro Ala Ala Pro Cys Leu Ser Lys Ala Ser Pro Asp Leu
705 710 715 720
Pro Glu Gln Trp Gln Leu Trp Pro Pro Val Pro Ser Gly Cys Ala Ser
725 730 735
Leu Ser Ser Gln His Ser Tyr Phe Asp Thr Glu Ser Ser Ser Ser Asp
740 745 750
Glu Phe Phe Cys Arg Cys His Arg Pro Tyr Cys Glu Ile Cys Phe Gln
755 760 765
Ser Ser Ser Asp Ser Ser Asp Ser Gly Thr Ser Asp Thr Asp Pro Glu
770 775 780
Pro Thr Gly Gly Leu Ala Ser Trp Glu Lys Leu Trp Ala Arg Ser Lys
785 790 795 800
Pro Ile Val Asn Phe Lys Asp Asp Leu Lys Pro Thr Leu Val
805 810
<210> 2
<211> 810
<212> PRT
<213> Homo sapien
<220>
<223> Wild type GPR156 isoform 2 protein
<220>
<221> MOD_RES
<222> (512)..(512)
<223> Xaa is glutamic acid or aspartic acid
<400> 2
Met Glu Pro Glu Ile Asn Cys Ser Glu Leu Cys Asp Ser Phe Pro Gly
1 5 10 15
Gln Glu Leu Asp Arg Arg Pro Leu His Asp Leu Cys Lys Thr Thr Ile
20 25 30
Thr Ser Ser His His Ser Ser Lys Thr Ile Ser Ser Leu Ser Pro Val
35 40 45
Leu Leu Gly Ile Val Trp Thr Phe Leu Ser Cys Gly Leu Leu Leu Ile
50 55 60
Leu Phe Phe Leu Ala Phe Thr Ile His Cys Arg Lys Asn Arg Ile Val
65 70 75 80
Lys Met Ser Ser Pro Asn Leu Asn Ile Val Thr Leu Leu Gly Ser Cys
85 90 95
Leu Thr Tyr Ser Ser Ala Tyr Leu Phe Gly Ile Gln Asp Val Leu Val
100 105 110
Gly Ser Ser Met Glu Thr Leu Ile Gln Thr Arg Leu Ser Met Leu Cys
115 120 125
Ile Gly Thr Ser Leu Val Phe Gly Pro Ile Leu Gly Lys Ser Trp Arg
130 135 140
Leu Tyr Lys Val Phe Thr Gln Arg Val Pro Asp Lys Arg Val Ile Ile
145 150 155 160
Lys Asp Leu Gln Leu Leu Gly Leu Val Ala Ala Leu Leu Met Ala Asp
165 170 175
Val Ile Leu Leu Met Thr Trp Val Leu Thr Asp Pro Ile Gln Cys Leu
180 185 190
Gln Ile Leu Ser Val Thr Gly Lys Asp Val Ser Cys Thr Ser Thr Ser
195 200 205
Thr His Phe Cys Ala Ser Arg Tyr Ser Asp Val Trp Ile Ala Leu Ile
210 215 220
Trp Gly Cys Lys Gly Leu Leu Leu Leu Tyr Gly Ala Tyr Leu Ala Gly
225 230 235 240
Leu Thr Gly His Val Ser Ser Pro Pro Val Asn Gln Ser Leu Thr Ile
245 250 255
Met Val Gly Val Asn Leu Leu Val Leu Ala Ala Gly Leu Leu Phe Val
260 265 270
Val Thr Arg Tyr Leu His Ser Trp Pro Asn Leu Val Phe Gly Leu Thr
275 280 285
Ser Gly Gly Ile Phe Val Cys Thr Thr Thr Ile Asn Cys Phe Ile Phe
290 295 300
Ile Pro Gln Leu Lys Gln Trp Lys Ala Phe Glu Glu Glu Asn Gln Thr
305 310 315 320
Ile Arg Arg Met Ala Lys Tyr Phe Ser Thr Pro Asn Lys Ser Phe His
325 330 335
Thr Gln Tyr Gly Glu Glu Glu Asn Cys His Pro Arg Gly Glu Lys Ser
340 345 350
Ser Met Glu Arg Leu Leu Thr Glu Lys Asn Ala Val Ile Glu Ser Leu
355 360 365
Gln Glu Gln Val Asn Asn Ala Lys Glu Lys Ile Val Arg Leu Met Ser
370 375 380
Ala Glu Cys Thr Tyr Asp Leu Pro Glu Gly Ala Ala Pro Pro Ala Ser
385 390 395 400
Ser Pro Asn Lys Asp Val Gln Ala Val Ala Ser Val His Thr Leu Ala
405 410 415
Ala Ala Gln Gly Pro Ser Gly His Leu Ser Asp Phe Gln Asn Asp Pro
420 425 430
Gly Met Ala Ala Arg Asp Ser Gln Cys Thr Ser Gly Pro Ser Ser Tyr
435 440 445
Ala Gln Ser Leu Glu Gly Pro Gly Lys Asp Ser Ser Phe Ser Pro Gly
450 455 460
Lys Glu Glu Lys Ile Ser Asp Ser Lys Asp Phe Ser Asp His Leu Asp
465 470 475 480
Ser Gly Cys Ser Gln Lys Pro Trp Thr Glu Gln Ser Leu Gly Pro Glu
485 490 495
Arg Gly Asp Gln Val Pro Met Asn Pro Ser Gln Ser Leu Leu Pro Xaa
500 505 510
Arg Gly Gly Ser Asp Pro Gln Arg Gln Arg His Leu Glu Asn Ser Glu
515 520 525
Glu Pro Pro Glu Arg Arg Ser Arg Val Ser Ser Val Ile Arg Glu Lys
530 535 540
Leu Gln Glu Val Leu Gln Asp Leu Gly Leu Gly Pro Glu Ala Ser Leu
545 550 555 560
Ser Thr Ala Pro Ser Cys His Gln Gln Thr Trp Lys Asn Ser Ala Ala
565 570 575
Phe Ser Pro Gln Lys Met Pro Leu Ser Lys Glu Leu Gly Phe Ser Pro
580 585 590
Tyr Met Val Arg Arg Arg Arg Ala Ala Gln Arg Ala Arg Ser His Phe
595 600 605
Pro Gly Ser Ala Pro Ser Ser Val Gly His Arg Ala Asn Arg Thr Val
610 615 620
Pro Gly Ala His Ser Arg Leu His Val Gln Asn Gly Asp Ser Pro Ser
625 630 635 640
Leu Ala Pro Gln Thr Thr Asp Ser Arg Val Arg Arg Pro Ser Ser Arg
645 650 655
Lys Pro Ser Leu Pro Ser Asp Pro Gln Asp Arg Pro Gly Thr Leu Glu
660 665 670
Gly Ser Lys Gln Ser Gln Thr Glu Pro Glu Gly Ala Arg Gly Ser Lys
675 680 685
Ala Ala Phe Leu Arg Gln Pro Ser Gly Ser Gly Arg Ala Pro Ser Pro
690 695 700
Ala Ala Pro Cys Leu Ser Lys Ala Ser Pro Asp Leu Pro Glu Gln Trp
705 710 715 720
Gln Leu Trp Pro Pro Val Pro Ser Gly Cys Ala Ser Leu Ser Ser Gln
725 730 735
His Ser Tyr Phe Asp Thr Glu Ser Ser Ser Ser Asp Glu Phe Phe Cys
740 745 750
Arg Cys His Arg Pro Tyr Cys Glu Ile Cys Phe Gln Ser Ser Ser Asp
755 760 765
Ser Ser Asp Ser Gly Thr Ser Asp Thr Asp Pro Glu Pro Thr Gly Gly
770 775 780
Leu Ala Ser Trp Glu Lys Leu Trp Ala Arg Ser Lys Pro Ile Val Asn
785 790 795 800
Phe Lys Asp Asp Leu Lys Pro Thr Leu Val
805 810
<210> 3
<211> 505
<212> PRT
<213> Artificial Sequence
<220>
<223> Wild type GPR156 protein, fragment 310-814
<220>
<221> MOD_RES
<222> (207)..(207)
<223> Xaa is glutamic acid or aspartic acid
<400> 3
Pro Gln Leu Lys Gln Trp Lys Ala Phe Glu Glu Glu Asn Gln Thr Ile
1 5 10 15
Arg Arg Met Ala Lys Tyr Phe Ser Thr Pro Asn Lys Ser Phe His Thr
20 25 30
Gln Tyr Gly Glu Glu Glu Asn Cys His Pro Arg Gly Glu Lys Ser Ser
35 40 45
Met Glu Arg Leu Leu Thr Glu Lys Asn Ala Val Ile Glu Ser Leu Gln
50 55 60
Glu Gln Val Asn Asn Ala Lys Glu Lys Ile Val Arg Leu Met Ser Ala
65 70 75 80
Glu Cys Thr Tyr Asp Leu Pro Glu Gly Ala Ala Pro Pro Ala Ser Ser
85 90 95
Pro Asn Lys Asp Val Gln Ala Val Ala Ser Val His Thr Leu Ala Ala
100 105 110
Ala Gln Gly Pro Ser Gly His Leu Ser Asp Phe Gln Asn Asp Pro Gly
115 120 125
Met Ala Ala Arg Asp Ser Gln Cys Thr Ser Gly Pro Ser Ser Tyr Ala
130 135 140
Gln Ser Leu Glu Gly Pro Gly Lys Asp Ser Ser Phe Ser Pro Gly Lys
145 150 155 160
Glu Glu Lys Ile Ser Asp Ser Lys Asp Phe Ser Asp His Leu Asp Ser
165 170 175
Gly Cys Ser Gln Lys Pro Trp Thr Glu Gln Ser Leu Gly Pro Glu Arg
180 185 190
Gly Asp Gln Val Pro Met Asn Pro Ser Gln Ser Leu Leu Pro Xaa Arg
195 200 205
Gly Gly Ser Asp Pro Gln Arg Gln Arg His Leu Glu Asn Ser Glu Glu
210 215 220
Pro Pro Glu Arg Arg Ser Arg Val Ser Ser Val Ile Arg Glu Lys Leu
225 230 235 240
Gln Glu Val Leu Gln Asp Leu Gly Leu Gly Pro Glu Ala Ser Leu Ser
245 250 255
Thr Ala Pro Ser Cys His Gln Gln Thr Trp Lys Asn Ser Ala Ala Phe
260 265 270
Ser Pro Gln Lys Met Pro Leu Ser Lys Glu Leu Gly Phe Ser Pro Tyr
275 280 285
Met Val Arg Arg Arg Arg Ala Ala Gln Arg Ala Arg Ser His Phe Pro
290 295 300
Gly Ser Ala Pro Ser Ser Val Gly His Arg Ala Asn Arg Thr Val Pro
305 310 315 320
Gly Ala His Ser Arg Leu His Val Gln Asn Gly Asp Ser Pro Ser Leu
325 330 335
Ala Pro Gln Thr Thr Asp Ser Arg Val Arg Arg Pro Ser Ser Arg Lys
340 345 350
Pro Ser Leu Pro Ser Asp Pro Gln Asp Arg Pro Gly Thr Leu Glu Gly
355 360 365
Ser Lys Gln Ser Gln Thr Glu Pro Glu Gly Ala Arg Gly Ser Lys Ala
370 375 380
Ala Phe Leu Arg Gln Pro Ser Gly Ser Gly Arg Ala Pro Ser Pro Ala
385 390 395 400
Ala Pro Cys Leu Ser Lys Ala Ser Pro Asp Leu Pro Glu Gln Trp Gln
405 410 415
Leu Trp Pro Pro Val Pro Ser Gly Cys Ala Ser Leu Ser Ser Gln His
420 425 430
Ser Tyr Phe Asp Thr Glu Ser Ser Ser Ser Asp Glu Phe Phe Cys Arg
435 440 445
Cys His Arg Pro Tyr Cys Glu Ile Cys Phe Gln Ser Ser Ser Asp Ser
450 455 460
Ser Asp Ser Gly Thr Ser Asp Thr Asp Pro Glu Pro Thr Gly Gly Leu
465 470 475 480
Ala Ser Trp Glu Lys Leu Trp Ala Arg Ser Lys Pro Ile Val Asn Phe
485 490 495
Lys Asp Asp Leu Lys Pro Thr Leu Val
500 505
<210> 4
<211> 814
<212> PRT
<213> Homo sapien
<220>
<223> E533D GPR156 canonical protein
<220>
<221> MOD_RES
<222> (516)..(516)
<223> Xaa is glutamic acid or aspartic acid
<400> 4
Met Glu Pro Glu Ile Asn Cys Ser Glu Leu Cys Asp Ser Phe Pro Gly
1 5 10 15
Gln Glu Leu Asp Arg Arg Pro Leu His Asp Leu Cys Lys Thr Thr Ile
20 25 30
Thr Ser Ser His His Ser Ser Lys Thr Ile Ser Ser Leu Ser Pro Val
35 40 45
Leu Leu Gly Ile Val Trp Thr Phe Leu Ser Cys Gly Leu Leu Leu Ile
50 55 60
Leu Phe Phe Leu Ala Phe Thr Ile His Cys Arg Lys Asn Arg Ile Val
65 70 75 80
Lys Met Ser Ser Pro Asn Leu Asn Ile Val Thr Leu Leu Gly Ser Cys
85 90 95
Leu Thr Tyr Ser Ser Ala Tyr Leu Phe Gly Ile Gln Asp Val Leu Val
100 105 110
Gly Ser Ser Met Glu Thr Leu Ile Gln Thr Arg Leu Ser Met Leu Cys
115 120 125
Ile Gly Thr Ser Leu Val Phe Gly Pro Ile Leu Gly Lys Ser Trp Arg
130 135 140
Leu Tyr Lys Val Phe Thr Gln Arg Val Pro Asp Lys Arg Val Ile Ile
145 150 155 160
Lys Asp Leu Gln Leu Leu Gly Leu Val Ala Ala Leu Leu Met Ala Asp
165 170 175
Val Ile Leu Leu Met Thr Trp Val Leu Thr Asp Pro Ile Gln Cys Leu
180 185 190
Gln Ile Leu Ser Val Ser Met Thr Val Thr Gly Lys Asp Val Ser Cys
195 200 205
Thr Ser Thr Ser Thr His Phe Cys Ala Ser Arg Tyr Ser Asp Val Trp
210 215 220
Ile Ala Leu Ile Trp Gly Cys Lys Gly Leu Leu Leu Leu Tyr Gly Ala
225 230 235 240
Tyr Leu Ala Gly Leu Thr Gly His Val Ser Ser Pro Pro Val Asn Gln
245 250 255
Ser Leu Thr Ile Met Val Gly Val Asn Leu Leu Val Leu Ala Ala Gly
260 265 270
Leu Leu Phe Val Val Thr Arg Tyr Leu His Ser Trp Pro Asn Leu Val
275 280 285
Phe Gly Leu Thr Ser Gly Gly Ile Phe Val Cys Thr Thr Thr Ile Asn
290 295 300
Cys Phe Ile Phe Ile Pro Gln Leu Lys Gln Trp Lys Ala Phe Glu Glu
305 310 315 320
Glu Asn Gln Thr Ile Arg Arg Met Ala Lys Tyr Phe Ser Thr Pro Asn
325 330 335
Lys Ser Phe His Thr Gln Tyr Gly Glu Glu Glu Asn Cys His Pro Arg
340 345 350
Gly Glu Lys Ser Ser Met Glu Arg Leu Leu Thr Glu Lys Asn Ala Val
355 360 365
Ile Glu Ser Leu Gln Glu Gln Val Asn Asn Ala Lys Glu Lys Ile Val
370 375 380
Arg Leu Met Ser Ala Glu Cys Thr Tyr Asp Leu Pro Glu Gly Ala Ala
385 390 395 400
Pro Pro Ala Ser Ser Pro Asn Lys Asp Val Gln Ala Val Ala Ser Val
405 410 415
His Thr Leu Ala Ala Ala Gln Gly Pro Ser Gly His Leu Ser Asp Phe
420 425 430
Gln Asn Asp Pro Gly Met Ala Ala Arg Asp Ser Gln Cys Thr Ser Gly
435 440 445
Pro Ser Ser Tyr Ala Gln Ser Leu Glu Gly Pro Gly Lys Asp Ser Ser
450 455 460
Phe Ser Pro Gly Lys Glu Glu Lys Ile Ser Asp Ser Lys Asp Phe Ser
465 470 475 480
Asp His Leu Asp Ser Gly Cys Ser Gln Lys Pro Trp Thr Glu Gln Ser
485 490 495
Leu Gly Pro Glu Arg Gly Asp Gln Val Pro Met Asn Pro Ser Gln Ser
500 505 510
Leu Leu Pro Xaa Arg Gly Gly Ser Asp Pro Gln Arg Gln Arg His Leu
515 520 525
Glu Asn Ser Glu Asp Pro Pro Glu Arg Arg Ser Arg Val Ser Ser Val
530 535 540
Ile Arg Glu Lys Leu Gln Glu Val Leu Gln Asp Leu Gly Leu Gly Pro
545 550 555 560
Glu Ala Ser Leu Ser Thr Ala Pro Ser Cys His Gln Gln Thr Trp Lys
565 570 575
Asn Ser Ala Ala Phe Ser Pro Gln Lys Met Pro Leu Ser Lys Glu Leu
580 585 590
Gly Phe Ser Pro Tyr Met Val Arg Arg Arg Arg Ala Ala Gln Arg Ala
595 600 605
Arg Ser His Phe Pro Gly Ser Ala Pro Ser Ser Val Gly His Arg Ala
610 615 620
Asn Arg Thr Val Pro Gly Ala His Ser Arg Leu His Val Gln Asn Gly
625 630 635 640
Asp Ser Pro Ser Leu Ala Pro Gln Thr Thr Asp Ser Arg Val Arg Arg
645 650 655
Pro Ser Ser Arg Lys Pro Ser Leu Pro Ser Asp Pro Gln Asp Arg Pro
660 665 670
Gly Thr Leu Glu Gly Ser Lys Gln Ser Gln Thr Glu Pro Glu Gly Ala
675 680 685
Arg Gly Ser Lys Ala Ala Phe Leu Arg Gln Pro Ser Gly Ser Gly Arg
690 695 700
Ala Pro Ser Pro Ala Ala Pro Cys Leu Ser Lys Ala Ser Pro Asp Leu
705 710 715 720
Pro Glu Gln Trp Gln Leu Trp Pro Pro Val Pro Ser Gly Cys Ala Ser
725 730 735
Leu Ser Ser Gln His Ser Tyr Phe Asp Thr Glu Ser Ser Ser Ser Asp
740 745 750
Glu Phe Phe Cys Arg Cys His Arg Pro Tyr Cys Glu Ile Cys Phe Gln
755 760 765
Ser Ser Ser Asp Ser Ser Asp Ser Gly Thr Ser Asp Thr Asp Pro Glu
770 775 780
Pro Thr Gly Gly Leu Ala Ser Trp Glu Lys Leu Trp Ala Arg Ser Lys
785 790 795 800
Pro Ile Val Asn Phe Lys Asp Asp Leu Lys Pro Thr Leu Val
805 810
<210> 5
<211> 810
<212> PRT
<213> Homo sapien
<220>
<223> E529D GPR156 isoform protein
<220>
<221> MOD_RES
<222> (512)..(512)
<223> Xaa is glutamic acid or aspartic acid
<400> 5
Met Glu Pro Glu Ile Asn Cys Ser Glu Leu Cys Asp Ser Phe Pro Gly
1 5 10 15
Gln Glu Leu Asp Arg Arg Pro Leu His Asp Leu Cys Lys Thr Thr Ile
20 25 30
Thr Ser Ser His His Ser Ser Lys Thr Ile Ser Ser Leu Ser Pro Val
35 40 45
Leu Leu Gly Ile Val Trp Thr Phe Leu Ser Cys Gly Leu Leu Leu Ile
50 55 60
Leu Phe Phe Leu Ala Phe Thr Ile His Cys Arg Lys Asn Arg Ile Val
65 70 75 80
Lys Met Ser Ser Pro Asn Leu Asn Ile Val Thr Leu Leu Gly Ser Cys
85 90 95
Leu Thr Tyr Ser Ser Ala Tyr Leu Phe Gly Ile Gln Asp Val Leu Val
100 105 110
Gly Ser Ser Met Glu Thr Leu Ile Gln Thr Arg Leu Ser Met Leu Cys
115 120 125
Ile Gly Thr Ser Leu Val Phe Gly Pro Ile Leu Gly Lys Ser Trp Arg
130 135 140
Leu Tyr Lys Val Phe Thr Gln Arg Val Pro Asp Lys Arg Val Ile Ile
145 150 155 160
Lys Asp Leu Gln Leu Leu Gly Leu Val Ala Ala Leu Leu Met Ala Asp
165 170 175
Val Ile Leu Leu Met Thr Trp Val Leu Thr Asp Pro Ile Gln Cys Leu
180 185 190
Gln Ile Leu Ser Val Thr Gly Lys Asp Val Ser Cys Thr Ser Thr Ser
195 200 205
Thr His Phe Cys Ala Ser Arg Tyr Ser Asp Val Trp Ile Ala Leu Ile
210 215 220
Trp Gly Cys Lys Gly Leu Leu Leu Leu Tyr Gly Ala Tyr Leu Ala Gly
225 230 235 240
Leu Thr Gly His Val Ser Ser Pro Pro Val Asn Gln Ser Leu Thr Ile
245 250 255
Met Val Gly Val Asn Leu Leu Val Leu Ala Ala Gly Leu Leu Phe Val
260 265 270
Val Thr Arg Tyr Leu His Ser Trp Pro Asn Leu Val Phe Gly Leu Thr
275 280 285
Ser Gly Gly Ile Phe Val Cys Thr Thr Thr Ile Asn Cys Phe Ile Phe
290 295 300
Ile Pro Gln Leu Lys Gln Trp Lys Ala Phe Glu Glu Glu Asn Gln Thr
305 310 315 320
Ile Arg Arg Met Ala Lys Tyr Phe Ser Thr Pro Asn Lys Ser Phe His
325 330 335
Thr Gln Tyr Gly Glu Glu Glu Asn Cys His Pro Arg Gly Glu Lys Ser
340 345 350
Ser Met Glu Arg Leu Leu Thr Glu Lys Asn Ala Val Ile Glu Ser Leu
355 360 365
Gln Glu Gln Val Asn Asn Ala Lys Glu Lys Ile Val Arg Leu Met Ser
370 375 380
Ala Glu Cys Thr Tyr Asp Leu Pro Glu Gly Ala Ala Pro Pro Ala Ser
385 390 395 400
Ser Pro Asn Lys Asp Val Gln Ala Val Ala Ser Val His Thr Leu Ala
405 410 415
Ala Ala Gln Gly Pro Ser Gly His Leu Ser Asp Phe Gln Asn Asp Pro
420 425 430
Gly Met Ala Ala Arg Asp Ser Gln Cys Thr Ser Gly Pro Ser Ser Tyr
435 440 445
Ala Gln Ser Leu Glu Gly Pro Gly Lys Asp Ser Ser Phe Ser Pro Gly
450 455 460
Lys Glu Glu Lys Ile Ser Asp Ser Lys Asp Phe Ser Asp His Leu Asp
465 470 475 480
Ser Gly Cys Ser Gln Lys Pro Trp Thr Glu Gln Ser Leu Gly Pro Glu
485 490 495
Arg Gly Asp Gln Val Pro Met Asn Pro Ser Gln Ser Leu Leu Pro Xaa
500 505 510
Arg Gly Gly Ser Asp Pro Gln Arg Gln Arg His Leu Glu Asn Ser Glu
515 520 525
Asp Pro Pro Glu Arg Arg Ser Arg Val Ser Ser Val Ile Arg Glu Lys
530 535 540
Leu Gln Glu Val Leu Gln Asp Leu Gly Leu Gly Pro Glu Ala Ser Leu
545 550 555 560
Ser Thr Ala Pro Ser Cys His Gln Gln Thr Trp Lys Asn Ser Ala Ala
565 570 575
Phe Ser Pro Gln Lys Met Pro Leu Ser Lys Glu Leu Gly Phe Ser Pro
580 585 590
Tyr Met Val Arg Arg Arg Arg Ala Ala Gln Arg Ala Arg Ser His Phe
595 600 605
Pro Gly Ser Ala Pro Ser Ser Val Gly His Arg Ala Asn Arg Thr Val
610 615 620
Pro Gly Ala His Ser Arg Leu His Val Gln Asn Gly Asp Ser Pro Ser
625 630 635 640
Leu Ala Pro Gln Thr Thr Asp Ser Arg Val Arg Arg Pro Ser Ser Arg
645 650 655
Lys Pro Ser Leu Pro Ser Asp Pro Gln Asp Arg Pro Gly Thr Leu Glu
660 665 670
Gly Ser Lys Gln Ser Gln Thr Glu Pro Glu Gly Ala Arg Gly Ser Lys
675 680 685
Ala Ala Phe Leu Arg Gln Pro Ser Gly Ser Gly Arg Ala Pro Ser Pro
690 695 700
Ala Ala Pro Cys Leu Ser Lys Ala Ser Pro Asp Leu Pro Glu Gln Trp
705 710 715 720
Gln Leu Trp Pro Pro Val Pro Ser Gly Cys Ala Ser Leu Ser Ser Gln
725 730 735
His Ser Tyr Phe Asp Thr Glu Ser Ser Ser Ser Asp Glu Phe Phe Cys
740 745 750
Arg Cys His Arg Pro Tyr Cys Glu Ile Cys Phe Gln Ser Ser Ser Asp
755 760 765
Ser Ser Asp Ser Gly Thr Ser Asp Thr Asp Pro Glu Pro Thr Gly Gly
770 775 780
Leu Ala Ser Trp Glu Lys Leu Trp Ala Arg Ser Lys Pro Ile Val Asn
785 790 795 800
Phe Lys Asp Asp Leu Lys Pro Thr Leu Val
805 810
<210> 6
<211> 505
<212> PRT
<213> Artificial Sequence
<220>
<223> E553D GPR156 310-814 fragment protein
<220>
<221> MOD_RES
<222> (207)..(207)
<223> Xaa is glutamic acid or aspartic acid
<400> 6
Pro Gln Leu Lys Gln Trp Lys Ala Phe Glu Glu Glu Asn Gln Thr Ile
1 5 10 15
Arg Arg Met Ala Lys Tyr Phe Ser Thr Pro Asn Lys Ser Phe His Thr
20 25 30
Gln Tyr Gly Glu Glu Glu Asn Cys His Pro Arg Gly Glu Lys Ser Ser
35 40 45
Met Glu Arg Leu Leu Thr Glu Lys Asn Ala Val Ile Glu Ser Leu Gln
50 55 60
Glu Gln Val Asn Asn Ala Lys Glu Lys Ile Val Arg Leu Met Ser Ala
65 70 75 80
Glu Cys Thr Tyr Asp Leu Pro Glu Gly Ala Ala Pro Pro Ala Ser Ser
85 90 95
Pro Asn Lys Asp Val Gln Ala Val Ala Ser Val His Thr Leu Ala Ala
100 105 110
Ala Gln Gly Pro Ser Gly His Leu Ser Asp Phe Gln Asn Asp Pro Gly
115 120 125
Met Ala Ala Arg Asp Ser Gln Cys Thr Ser Gly Pro Ser Ser Tyr Ala
130 135 140
Gln Ser Leu Glu Gly Pro Gly Lys Asp Ser Ser Phe Ser Pro Gly Lys
145 150 155 160
Glu Glu Lys Ile Ser Asp Ser Lys Asp Phe Ser Asp His Leu Asp Ser
165 170 175
Gly Cys Ser Gln Lys Pro Trp Thr Glu Gln Ser Leu Gly Pro Glu Arg
180 185 190
Gly Asp Gln Val Pro Met Asn Pro Ser Gln Ser Leu Leu Pro Xaa Arg
195 200 205
Gly Gly Ser Asp Pro Gln Arg Gln Arg His Leu Glu Asn Ser Glu Asp
210 215 220
Pro Pro Glu Arg Arg Ser Arg Val Ser Ser Val Ile Arg Glu Lys Leu
225 230 235 240
Gln Glu Val Leu Gln Asp Leu Gly Leu Gly Pro Glu Ala Ser Leu Ser
245 250 255
Thr Ala Pro Ser Cys His Gln Gln Thr Trp Lys Asn Ser Ala Ala Phe
260 265 270
Ser Pro Gln Lys Met Pro Leu Ser Lys Glu Leu Gly Phe Ser Pro Tyr
275 280 285
Met Val Arg Arg Arg Arg Ala Ala Gln Arg Ala Arg Ser His Phe Pro
290 295 300
Gly Ser Ala Pro Ser Ser Val Gly His Arg Ala Asn Arg Thr Val Pro
305 310 315 320
Gly Ala His Ser Arg Leu His Val Gln Asn Gly Asp Ser Pro Ser Leu
325 330 335
Ala Pro Gln Thr Thr Asp Ser Arg Val Arg Arg Pro Ser Ser Arg Lys
340 345 350
Pro Ser Leu Pro Ser Asp Pro Gln Asp Arg Pro Gly Thr Leu Glu Gly
355 360 365
Ser Lys Gln Ser Gln Thr Glu Pro Glu Gly Ala Arg Gly Ser Lys Ala
370 375 380
Ala Phe Leu Arg Gln Pro Ser Gly Ser Gly Arg Ala Pro Ser Pro Ala
385 390 395 400
Ala Pro Cys Leu Ser Lys Ala Ser Pro Asp Leu Pro Glu Gln Trp Gln
405 410 415
Leu Trp Pro Pro Val Pro Ser Gly Cys Ala Ser Leu Ser Ser Gln His
420 425 430
Ser Tyr Phe Asp Thr Glu Ser Ser Ser Ser Asp Glu Phe Phe Cys Arg
435 440 445
Cys His Arg Pro Tyr Cys Glu Ile Cys Phe Gln Ser Ser Ser Asp Ser
450 455 460
Ser Asp Ser Gly Thr Ser Asp Thr Asp Pro Glu Pro Thr Gly Gly Leu
465 470 475 480
Ala Ser Trp Glu Lys Leu Trp Ala Arg Ser Lys Pro Ile Val Asn Phe
485 490 495
Lys Asp Asp Leu Lys Pro Thr Leu Val
500 505
<210> 7
<211> 120450
<212> DNA
<213> Homo sapien
<220>
<223> Wild type GPR156 isoform 1 genomic DNA
<220>
<221> variation
<222> (117166) .. (117166)
<223> n is a, g, t, or c
<400> 7
ggggaccgtg ggcgtcctgc acatagcagc gggcttggcg cttctcggcg gtccgacgct 60
gatgaggtga gcacagcgac cttaaggatc cacaaaactt caaacactta attattaagt 120
gaaagtggaa agggggaggg gctttctctc cctttccaga atctgggcag tttgtttgga 180
accggtaaag aaactctcat aggaacttga ggtgagcagg ggtcacgcat cagggatgcg 240
agtggcaatt tcagtggaag agacgggaga gtactgtaat ttggtgtgaa gatggggccg 300
tgggttttct gctgaataag cgaccggctg tgctgaaaat gagagatccc gaaacagttt 360
cccaccgcct gtagactttc cagagtctcc tcacgccgaa tctgctttgc agggcatgtt 420
cacccccagg gtgtagagtg gcgggcacga tgggctcccc catggagatt gcaaagtcct 480
gaaaagggac aattgtattg cactgcgtct gttgaactgc cttgcttctg ggcatgaggg 540
agtcacctgg aagctgcaac atccttgtac cctggcaagc agccctttcc aagttagctc 600
tgtcagaaac tagaggcctc taggtagaac tcaaggtatc catgtactcg tgaagaatac 660
aaaccttgag gtttttaaaa tcgaattttg ttaagatttc aggatagaaa tctgggaaga 720
gaagtcatgg catggcataa cttacccctt tgttagtttt ctaggtacat gcatgcttga 780
attagaggta aatgatgccc tagcctatca taaaatgtct ttcctggtgt agttctttaa 840
accagaatat ggaggataac attacatttt tgcatcctag ataaaaggga aagattttca 900
gatggggctt acacagcggg agaaattgtt gatatagttg tattaggcag caaggcctgc 960
aaagaaaaac ttctttttct ccaccagtgg ctgaattctg cacagaatgt ctcctcgcag 1020
tctgggtagc agcccggctt gcaaaaacag tgcttctttc attgctgcag gtggggcaaa 1080
tgcgcttgcg gataaatggc tggggaagcg tttgcttaca ggttaaggca atttgagtct 1140
ggagaataaa gtgctttagc aggctgtgct tgagttaggt gtcccttgtg aggaatagag 1200
gtggctttct ggtccccatt ttgccagcct aattcccctt cagggacact actgtctctg 1260
gaatgttccc tctgtttccc cttctcttcc acccccagct tttagcttct ccccattccc 1320
cagtaaagtc tagaattgag cctggtcaga gtcaaagttc tgatagccta gggatataga 1380
acttcaagcc tggtgaaggc agaaatgaga cctaggagag acccaagatg ggtgagatga 1440
aacaactttc agcctagaag gctctcaaaa gagtggaaaa ataatgattg agggaaacag 1500
attctctgga aaggagaata ggtgcttaag tgtttgtttt cagctgaggg ttttaatatt 1560
tccatttttg ttgtttaacc ataagggaat ttccattata gggtaggagg aggatgaggc 1620
cttctctgaa aactgcatcc ttctccttga atttgcattt tattccattc ttatgtaggt 1680
ttcagagatt aattggggga agggggagag aggaaagaag ccagaggctc tgacatgctg 1740
cagaaacagt gcaacgtgga ctgacttggg ctgcaaaggt ggatttgggg gttgaaagaa 1800
atgttctaca tttagttgaa aaaaaaaaat cagagccttt attttgcaaa ggtcttgaga 1860
atcagaacat tcatgtttag ttgctgatga attttgcctg ataaaggatg caaatcacta 1920
tctcaccttt ttttctccag tactttatta tgaaaaattt tagacataca gagatgtttt 1980
ctacctctca ttttataaac ttattatctt aaaacaaact tgttaataaa aatcagtgtt 2040
tagaatccag acatatgtga tctggtcctg gacagagctt gaatcagaag gtgtttcaaa 2100
tatagatgtg tgaaggatat taacatttta agaaaaaaat atggatctta ttcttctgac 2160
tttcccataa gaatcttgag cagacccctt aactgccttc tttttcccat tcttaaaatg 2220
tcagtcagtt ggatgatatt actctcctgc ttaacaccct ccaatggctt cccctcacac 2280
tgtgaataac attcaactct ccaccagggc ttgtgatttg gtctggtgcc ctcatattct 2340
atggccgtcc tcttgcttac catcgtcctt gctcttccct ctgcctgaac actcttcctt 2400
cagacactgc cactgcttct tttctcagct cattccagtt tcttttcata ctctccagaa 2460
tgatggccac ctgatctaaa acagcctgtg gtcactccct gtcttctgac cctgctttat 2520
ccttcttcat ggcacttagc actccctgac actatatagt atatgtgttt ccttgttaat 2580
tgggcatgtt ccccactcta atgtaaactc catcaagaca aggaattttt ttgtcttatt 2640
tatggctgtg ttcctatttg gtatattatg agcaattaat aaataactgt tggattaatt 2700
aggtaactaa attacacaaa taaggcattg actcccataa gggtggcaga acccttggta 2760
aaatactaga agtcctttga ggtaattcat aattcaagtt aatcaatatt tgataggtaa 2820
atgatgaccc tggagatcag tggcctcttt tatcctcaca gcacttctca gctgaatcct 2880
atgctaatag ctggccagtt ttgacaaacc cacatcccaa acaagacata aaatatttca 2940
gtcacagaac ttttcctcac gtctctttct agtcacctcc accccacaga agcagcaaac 3000
cttgttctga tttctaatat catagattag tgttgctggt tcctgaattt catataactg 3060
cagttacaca gtatgcactc ttgtgtttgg cttctttttg ccctacacaa tgtctgtgat 3120
attcatctgt gccattgtgt gtatcagtag ttcatttctt ttttttccaa ggtagtattt 3180
attgtatgaa tattgaccat gtgtttatct gttctcttgt tgatagatac ttggttgttg 3240
ccagtttgtg gcaattttga acaaagctgc tgtgaaccta taaagggtct gcctcatctt 3300
gagtcttctc tactttatat gaaaatcttc cttgtgccac caatgcagag agaagtatgg 3360
caaggttatg ggggctgtga ctgatgtagc agcttgcatg taccccagcc agtgctctct 3420
ctagacagct ctgctgggag ctgacctgct tcccacttta gagggaaagc acttggaaaa 3480
tgagtgtcta acaaattagc gagccctcca gtgcactctt aagtgcttta aatccttgaa 3540
agagacactg tggaatgcct gctgccatca ctgttgtatt tccctcctcc tctcagcttc 3600
cccatcccag cacaagttga ctctaatcag cttctgagca ttatgctact gaggggttta 3660
aacattcatg agcaagagtc ttgttcagag cctgataaaa tattcatgtg tttccatggg 3720
gcattggttt ccatctagac ttctcaaggc atttttctga gatgcatgtc gtaattgtga 3780
agaactcaga cagtgatgga tgatacggcc ctgtgttatt aaaccctacc acacagagca 3840
ccttgctttc tagggatgga gaagaatgag cacacagaaa aattgacatt aatcctgtct 3900
agatcaagag aaaggctaca tgtactgata aaaatggctt gagtaaagag gggcctgtta 3960
atatagtacc aacaaaggta tgaatccata gaggagagtg aaaagaactt gttaaaatga 4020
gaggaatgct gggatgcagt cattccaagt ggaagaatgg gggaatcagc attgtaaaat 4080
gcacagttcc tttgacactc atgtggacga ggttcatatg agacaactgt gctgagtgct 4140
gtaattatca caacctgcta tgagaggatg agagtagaag tggaggctag gcagggtttc 4200
caagtagagc cagagagcta ttccaagagg agtcaacatt tctcttcaag gaagaagtgg 4260
ctttgagtca ggttctgaag gaggtgtgcc tctttgactg gcagctgcgg tgtggaaggg 4320
actttccaga gagacagaat agcatgatag agtgagggcc aaagtgccgg tgtggtgtga 4380
gtaaggagag aaggtgggtg gatgggggtc agggcagggt tgcagcaaga cataaagcag 4440
gagagctaaa ggccagctta tgaaggccac aggaggatgg acttcagtct gtttgctgga 4500
gggccgtgta acttttggcc agagattggg ttacattttg aggagttctt gggaagtata 4560
tccaccctag gcaaggcctt gaggtatgtt tatgtccaag gcatttccag aatattctgc 4620
tgtgtccaga acactatgaa gactctacgt ggtctactct aagagaggta aaccagagga 4680
ggtcagatat actcagtata ctcctgggac tgaccagaaa caggcctcac caggcacctc 4740
tctgccccca gcacacaaac actcagaata ttctgagtca gattgaatcc acagcattcc 4800
ctagacttct tcatgaccac tttgcctcag ctgggggagt tgcaatgatc taagtatccc 4860
cttatcacct gaatctgggc caggatacct cagacatggg ttgccaggca actgagggct 4920
aagtgatgca gctggccaat catccccaca aagcccaggt ctgctttgac caggccatcg 4980
ggctgtgacc agagaggcaa cttggggggt tgaggtcatg cagactgatg acttgtggac 5040
acaactgcca ggccccttcc atatgtcttc ttcctttggg ttgcagattt ctattcaaaa 5100
atgcctcagg atgttgattt tttaacccat aataaaaata gtgaagtagg gaggagtgtt 5160
aaacatgtca gtcatctata ccttatgttg tcattgggaa gaaataactg tggaaacaat 5220
tgtcccggga aagtcagtct tcagtcttgc agtgaggagc tttgcatatg tggagattag 5280
ctagaaagct ctggagttct gatggtgaga agggatttct tgggtcaagg ataggaaagg 5340
gcaagggagg accttcatga ttctccccag ggctttgctg gttggaattg ctcttctgct 5400
gccatgggta gcatggggtt tcagtgactg aaaacaccca ggaaagtatg ctctgggtct 5460
tcatgttgcc atctgcctac actggaatgt cagaccatca gtcagcactg ccagctctcc 5520
atcttgattt tctaagagtt attgagaaaa ccttgaaagg gaaggcagaa gtgggtgtct 5580
taactaggga aatgccaagg tcctaaaggt gtggtctagg ttgaaggtgt ggtaagggcc 5640
tgaagtcatt ggtctggcag tacttcagac caataaagtc tttcttggct cttatctaaa 5700
atattcctga ttttctgtgt gaggtggaat ctctcaagtg ctgcattaat cagtcttttg 5760
gctgaacagg taaatagggt gcatgcttaa ttgagtgcct tttctttttt taaagtttca 5820
gcttttattt tacattaaga ggatacatgt gtaggattgt tcatgggtaa attggaccca 5880
ggcataagca cagtacccaa taggtagttt ttcaacccat gccccctccc tcccttcccc 5940
ctgtagtagt ctgcagtatc tatctttcct gcgtttatgt ccatgtgtgc tcagtgttta 6000
gctcccactt ataagtgaga acatgtggta ttttgttttc tgttcctgca ttaattcact 6060
taggataggc ctccaactgc atccacgttg ctgcaaagga catgatttca ttatttttta 6120
tcctatggtg tttatgtagc acattttctt catccagtac actgttgatg agtgcctagg 6180
ttgattccac atctttgcta ttgtgaatag tgctgtgatg cacatatgca agcatgtgta 6240
tttatggtgg aatgatttat atttctttga atatataccc agtaatggga ttgctgggtc 6300
aaaggtagct ctgtatttaa gttttttgag aaatctccaa actgctttcc acagtggttg 6360
tactaattta cattcccacc aacaatgtat aaatgttccc ttttcttcac agccttgcca 6420
gcatctgttg ttttttgact ttttaataat agctattctt actggtgtga gatggtatct 6480
tattgtggtt ttatttgcat ttctctgatg attagtgatg ctgagcatgt tttcatgtct 6540
attggccaca cttgtatgcc ttcttttaag aagtgtcttt tcatgtcttc tgcccacttt 6600
ttaatggagt tatttgattt ttgcctgttg atttaagttt cttatatatt ctggatatta 6660
gacctttgtc agatgcatag tttgtgaata ttttctccca tgctgtaggt tgtttactct 6720
tttgatggtt tctcttgctg tgcagaagat ctttagttta attaggtccc acttgtcaat 6780
ttttgttttt gttgcagttc tttctgggga cttggccata aattctttgc caaggccaat 6840
gttgataagg gtatttccta ggttttcttc tatgattttt atagtttgag gtcttatgtt 6900
aaatctttaa tccattttta gttagttttt gtatatggtg aaaggtaagg gtctagtttc 6960
attcttctgc atatggctac cagttatccc agcaccattt attgaatagg gagtcctttc 7020
tccattgctt gttttttgtc agccatgttg aagatcagat ggttgtaagc gtgcagcctt 7080
atttctgaat tttctattat gttccattag tctatgtgtc tctttttgta ccagtaccac 7140
cctgttttgg ctactctagc aaattctttg gaattaagga aaatagggac acaatttatg 7200
aagacctctg ggatgtagcc aaagcaatgt taagaggaaa gtttatagcc gtaaatgcct 7260
tcatcaagaa gctggaaaga tctcacatta acaatgtaac tttgcattta aaggaactat 7320
gaaaaaagga caaaccaacc ccaactctag cagaagaaaa gaaataacta aaattaaaga 7380
aaaacttaat gaaattgaga tgcaacaatc catatgaaag atcagtgaaa ccaagaatag 7440
gctatttgaa aaaataaata agattgatag actgctagct aggttaacaa agcgggagga 7500
gacagtgaga gagagagaga ggatccaaat aagtacaata gaaataacaa agatgacatt 7560
acaactgatc ctatagaaat acaaaagatc cttggagaaa actatgaaca gctctatgca 7620
cacaaattag aaaatctaga agaaatcaat caattcctgg aaacaatctc ttgagattga 7680
atcggagaga ttgaagtcct gaatagacca acatcaaact ctgaaattgc atcagtaaaa 7740
caaacaaaca aacaaaaaaa acccttccaa ccataaaaag ccctggacca gatagattca 7800
cagccacatt ctatgagaca tgcaaagaag aactagtacc aatcctacta aaacttacag 7860
aaaatagagg agcagggact cctccccaat tcatcccatg aagccagcat cagcctaata 7920
cccaaatctg gcagagatat gatgaagaga tatgattttt gtgtctatgt tcagaccaat 7980
atccctgatg aacatagaca caaaaatcct caacaaaata ctagcaaacc aaatttagca 8040
gaacatcaaa aagttaattc accatgatca agcaggcatt attcctggga tgcatggttg 8100
gttcaacata cacaaatcat agtgagtcac catgtaaaca gaattaaaag caaaaaccgt 8160
tatgatcatc tgtgtcatct caatagacac agaaaaagct tttgataaaa tctaacatct 8220
cttcatgata aaaactctca acaaactagg catcgaagga acatacctca aaataataag 8280
ggccatccct gataaaccta cagctaacat catactgaat gggcaaaagc tggaaccatt 8340
ccccttgaga actggaacaa ggcaagaatg cccactctca ccactgctat tcaaggtagt 8400
gctagaagtc ccagccagca cagtctggca atagaaagaa ataaaaggca tccaaataag 8460
aaaagaagaa gatgaactat ctccctttgc tgacgatata attctatact tagaacaccc 8520
caaagactgt tccaaaaggt tactagaatt gaaaaatgat tttagcaagg tttcaggata 8580
caaaatcaat gtacgaaaat cagtagcatt tctaaacacc aataacgtcc aggctgagag 8640
tcaaatcaag aacatgatcc catttacgac agctgcaaag aaaaggaaat acctaggaat 8700
atagcaaacc aaaaaggtga aagagctctg caaggagaac tacaatacac tgctgaaaaa 8760
aagttagaaa caacacaaat aaatgaaaaa atatcccatg ctcatggatt agaaggatca 8820
atatcattaa aatggtcata ctgcccaaag caatgtatac attcaatgct attcctatca 8880
aactactaac atcagtcttt acagaattag aaaaaactat tctaaaactc atatggaacc 8940
caaaaagagc ctgaatagcc aaagcaagcc tgagcaaaaa aaaaaaaaca aagccggagc 9000
atcacactac ctgagtgcct tttctgaaca gatatttcaa tgattctgtg attattcatg 9060
agccagtgat ggctgcctgc ttttggatgc tgctaggata aatgcagaag atcagagtga 9120
agagggagag ggaagcataa cagcagcaga gaggaaaagg gaagagagta gtgacgtgct 9180
gaaatcgcag agattgtggg tacccagtta tctacaagtg agaaacaggg ataaaagaag 9240
atcaaataac tacccatggg aattttacat gcaaatattg ctgacttcca aggcagctgt 9300
gaggagaaag gaagggagga gacacaaagg cagctgtcac agtcaatccg aggaatatta 9360
ataaaaactt gacacatgaa aacacatggc cgtatcacaa cagcctgggt cccagcaagg 9420
atgtctattc aaacccctct ttcacatttc cttatattca ttcacagtat taggtatttt 9480
gcaagacatt catttgcact tgcaaagata cacaaatgca gagtacttaa aagggtaaac 9540
tatcctaaaa tattagtggt gagattataa atgattattt gtattttttc aacttatcta 9600
tgttttccat gattgtttta agaagtgtga atttctttga taatcagaaa aacattaagg 9660
agaaaggggg ttaagtaggg aggtagagaa agaggcatgg ggtggggaga gaggattgta 9720
gaaaagaaaa atatgttgga agatgaatga acaattttaa aactttatgt ttcacagact 9780
gctagcttgt gcatattttt ctttattatt gaatatatat gtttatcacc ctcagaagat 9840
ctggaagtac caattggcat gaaactgaat tgcaaatact gagctaagta tcacacctcc 9900
aagaccattg ccttggccag tgccattctg tgtgtgacat gtggcttcca gtgatgctca 9960
aagtattttc cgccaaaggc taatagagaa cacttcaaac ctgggcagca gcatctctcc 10020
cacagggttt aatatttata cttgtagcca cgtggctggc tttgtgcttc tcatctctga 10080
agtatggaac aggagccaac aaaggctgtc aatagttgga gtagtgggat tttccaagac 10140
aaaagcgtga gttattctcg tccacgtgtt tgctggctgc tcactggctc aggcagcccc 10200
ttggcaagct ctgtggctga ggctttaaat aaatagatgt agtttttgtt tcacaaccac 10260
tgaccttttc tggaggcact gttgattctg ggctttaatt ggcttctgtt gagtgacaca 10320
aggtgaaccc tctcttcaag agcagaagct cctatctgct gttaaccacc agcatcaatt 10380
caaagcaaat gccagaggac cacatacctc actgaactct ggggactggg gttacttgta 10440
gttatgtctc aataaatact ttttatattt taacttttgc atttttaagt tgtaaaagct 10500
atacacactc atggtaacaa gtctagtaag acagcagtat ataaagaaaa tatggccagg 10560
cgcagtggct caccccatag ttccaatact ttgggaggcc gagatgggtg gatcacttga 10620
ggtcaggagt tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatta 10680
ggctgggtgc ggtggctcac tcctgtaatc ccatcacttt gggaggctga ggcgggtgga 10740
tcacaaggtc aggagttcaa gaccagcctg gccaagatgg tgaaaccctg cctctactaa 10800
aaatacaaaa attagctgag cgcagtggca ggcacctgta atcccagcta cttgggaggc 10860
tgaggccgga gaatcacttg aacccggggg gcagaggttc cagtgagccg agatcctgcc 10920
actgcactcc agcctgggcg acagcatgag actccgtctc aaaaaaaaaa aaaaaaaaaa 10980
attggccagg taaggtggct catgcctgta atcctggcac tttgggaggc cgaggtgggt 11040
ggatcacctg aggtcaggag ttcgagacca gcctgaccaa caaggtgaaa tcccatctct 11100
accaaaaata caaaaattag ctggacgtgg tggcaggcgc ctgtagtccc agctactcgg 11160
gaggctgaga caggagaatt gcttgaacca gggaggcaga ggttgcagtg agccgagatc 11220
gcaccactgc actacaacct gagcgatgga gcgagactct gtctcaaaaa aaaaaattag 11280
tcaagtgtgg tggcgtgtgc ctgtaatccc agttacttga gagggtgagg cgggagaata 11340
gctcgaaata gcttgaaccc aggaggcaga ggttgcagtg agccaagatt gtgccactgc 11400
actccagctt gggctaccga gggagactcc atctcaaaga aaaaaaaaaa gaaagaaaat 11460
ataagtaatc tccaccttct ctcactccca tctttctgac aaaaccacta tttaaagcgc 11520
ccaggctggg cgtgcgggct gacatctgta atctgagcac tttaggaggc agaggcagga 11580
ggatagcttg ggtccaggag ttcaaaacag cctggacaac atagtgaaac tccgtctcta 11640
tgaaaaaaaa aaaaaaatag ccaagtgggt ggtatgtcat cctagctact tgagaggatg 11700
aagtgggagg atcgcttgaa cccaggaggt tgaggctgca gtgagctgtg atcatgacat 11760
tgcactccag cttgagtaac agagtgagac cctgtctcaa aaaaaaagtt tcatgtgtat 11820
tcacatgtca cgatcacagc tcactgcagc ctcaacatct ccagctcaag ggatccttcc 11880
acctcagcct gccaaataac tgggaccaca ggcacatgcc accacacccg tctaattttt 11940
aaacattttt gtagaaacga ggtctcactg tgttgcccag gctgatcttg aattcctcgg 12000
ctcaagtgat cctcccacct cagcctccca aagtgctggg attataggca tgagccactg 12060
cactcagccc cttcactcct tttctatgtt caaacaaaca tatgagtgtg tagacttatt 12120
ttctattgta tgtgaaaatg gaatcatata tgttattatt tctttcattt tatttagtac 12180
atattatgta cattattcta gattaacaca tataattgat ccaatttatt atttttaata 12240
gctacctaat attccattat aggaggttcc ataatttctt cccattcatt acttccccat 12300
tgatagatat tcatgttttt cttccaactt tttttgcaca acaacttatg ctacaataaa 12360
cattctacat ttattcctat actttgggtt ttatttccat aggagagatt cccaaaattg 12420
tcatttttgg gtcaaaggga atacacaatt ttaattctca ctgtaggtct cctttacagc 12480
agttgtttct ctcctccttt tgtctttctc tcccctctcc caccacattt tgccagcagg 12540
gcctgtgtgt ttaagaagga aagcctgcag tgagaactcc tctgtgccaa gtgtggatta 12600
tatcagctta gtggggaact ggagtctgca gtgtctcagt tacattgtgt ctctcttgct 12660
tttggttggc cagactgttc acaattcccc ttgctgattt attccatgct gtggaattat 12720
acatggtctt catccgtggc aggatcatct gaggggtggc tttttgggaa gggtgtcttt 12780
tcagaaagaa taggctcagt tactgtactt tctcacaaag ctatatctgt tatgtttttt 12840
tgttatgccc tttctttaat agttggattg aaaaaggttc ttcaattccc atcccggtct 12900
tctgtcttca ttttgaggac ttgggattta gggagtttta tgagtatata atcaatcaac 12960
tgtaactgat tatttgacat gaggataatt agttaagaag gtaggggtct tggagcttaa 13020
ggatcagtgc caagcaacag acgtgaacat ttttaaacaa atggttttaa caaacccggt 13080
attaggagca agcttcccag gagtactaag ctttcatttt ttaattttgc ccttgctggg 13140
atgtaaaact tcagtctagt ctaccagaat agagaggagc tggattctcc accacaccag 13200
ggctggagag gagaaaatgt cagagaagcg ttaagggaag ctggtaagta caaataagtg 13260
aaataaatat aaacagtgaa ctgacaaaat ggcaaaaagt gaatgaaatt tgaaaatcct 13320
cagctgaaga ttattgtgta accagtggtc ctgtgagcta gtggacactt tataaaaatc 13380
tgtgatctct aaaacatatt agatacccca gtgtgaatct gtgttcagaa tacaaccatt 13440
agctaagcaa gacagagaaa tgataagtcc tgttggcaga tattttgcta ttgacttcta 13500
taacatatgc tgcaattttt actcagcagc tttggaatgg atttctatgt cctaggttga 13560
aaactaaact aaaagaaaaa cagaatagaa gttactgcac ttaatttcta aggagaaaat 13620
tttaacttta gtttgtgcat gtatatgcct gcaaaataag cattaccctt tatgttaata 13680
caaacttcac atgaatgttt aattttcaaa tatgcactga ccagtaataa tgatggcaaa 13740
attagactct atagtaggtt tatgttttat aacttaggga ttctataatg tatcttagtt 13800
gatgtcgtag ttaatagtaa ggatagtaat atcttataca gtttgcactg tcgtctgagt 13860
aaagattatc tttaaacatt tgttcctgtc agaaaaattt taaggctaaa cctattataa 13920
gatattaagc atctgatttt ggctataatg gactatctgt gagtagattt ttactcctat 13980
acaggacatc tagaaaagct gagttttaaa aatctatttg aaggcataga agacctaata 14040
aggcagctag gacttgagag ctaagacctc agaaagaaga gaaactcatt gagtgttcca 14100
aattctaggc tactttttcc ctgtagacac ttaccatttt taagtagcac atgaggagaa 14160
cccaaacaat aagcagctgc taaaatcaga gaagccaggc agattattcc acagtctgat 14220
agggctgggg aggaaaaaaa aaaattgaat tcaaggaaac caaatgattc aggacatgag 14280
aaaccatgat catggacaga aaagaggccc agaaaaatca actcaatagt ctaagcaatt 14340
ttccttccaa gtcattcact gatttataag tagcgcagac caagaggttg caaaaatcca 14400
aacacaaaga aggtgctaaa aagctgagaa gctaatcaga gctacttgca atcttattac 14460
actaggaaga taaaaattat tatagaatgt aaagcccacc aatgtggtat ggcctgaaaa 14520
acaccctaag ctttcagttg ggactgctga cggattatgc ctgaccagtt aaaggaaacc 14580
agaaatagac ccggtcaaat aaaatattga agtccatttc ccgatcaact tagtcactga 14640
ttagattaaa gtaatctgtt cttattttaa caccctagca taagtcttct ccatattctt 14700
tggagaagaa aaaatgatcc agaacctgtg tatttttcat atgtggtttc tggtattcag 14760
caaagcaaaa caaaacaaaa acaggcatac caagatatag tttccagaat atggtacaga 14820
gagaacccag acttcctgag ttgagaagac agagctcccc atgtctgggg agaccagggc 14880
aactagagtt tgtaggacag agtattggag aggagagagc tgcagagaga accccagagt 14940
tcctcacagg gtacacctca agtataaagc tgagtactga gcagcacatg catgtaagga 15000
aactacctgg gataaagaaa gaactaccca aaaggattag aagaaatagt gctcattgtt 15060
cacacagggc tgggaattgt gcctattccc accagctaga cttgaaaagc tcataattca 15120
tggagggttg ggtagtatac tttgaaagac catgccttag tagtgggaag tagccctaga 15180
ttgagcactg cactgatcct gtctaacaaa tcttttaaaa agacccaaaa ggaacaaatt 15240
gttccagtta atttgactgc atcccagaac aaagctcaaa actatttaga ggtatttgga 15300
atagcagtat tagtaatatt gcagagggaa gaatattgcc agggataaag aaaatcattt 15360
cataatgata aaggagttga ttcatcagaa agacataaca gtactaaaca tttatgcatc 15420
taataacaga acttcaaaat acataaatga gaaattgata gtgttccaag gaggaataga 15480
caaatccata actgtagtcc aaagtttcat taaccttctc tcagtaattg atgaaataac 15540
agaaaataat taggtatata aaagaagata aaaatacaat caactagctt gacctcattg 15600
atctttataa gatactctac ccagctacag caaatacata ttcctctcaa gtgtacatgg 15660
aacatttatc cagttagacc atattctgaa ccataaaaca agtctcaata aatttaaaag 15720
gattttagtt atataaggtg tgttcttgat cacaatggaa ttaattaaga aatcagtaac 15780
aaaattctca aatatttggt aactaaataa catccttcag aataactcat tagtcaaagg 15840
agaaatcaaa aggaaaatta gggccgagtg gagtgactca catttgtatt cctaacactt 15900
tgggaagttg aggcaggagg attgcttgag gccaggagtt gaagatcagc ctgggcaaca 15960
gagtgagagc ctgtctttaa aaaaaataga aaaaaaaaat tagctgggca tggtggtgtg 16020
cactcataat cccagctact tagctggagg attgctttag cctaagagtt tgaggttgca 16080
gtgagctatg atcatgccac tgcattccag cctgggcagc agagtgagac cctgtctcta 16140
aaaaaattat ttttaataaa aaataaaggg aaatgagaaa atatttgggg ctgaaagtaa 16200
aagctcatat atcaaaagca gtacttaggt ggaattttat agtattataa gcttataagg 16260
tggggcacag tggctcacgc tggtaatgcc aacactgtag gaagtcgaga caggcggatt 16320
gcttgaaatc aggagttcgg gaccagcttt gacaacatgg caaaaccctg tttctataaa 16380
aaatacagaa aattagctgg gtatggtggc acgtgcctgt agtcccagct acttgatggg 16440
ggctgaagca ggaggatcac ttgagcccag gatttcgagg ctgcagtgag ccgagatcac 16500
accactgcac tccactccag cctgggtaac aaagtgagac cctgtccccc cacacccccg 16560
caaaaaaaag cttataagaa gaaaggtctc agattagtgt cctcagcttt catcttaaga 16620
aaccaaaaca gaaaaagagc aaatgaaatt caaaataagc agaagaaaga aaataagaaa 16680
tatcaaagca gaaatcaata aactagattt tgaaaagtag agaaaatcaa tgaaagcaaa 16740
tgctgtttca ttgagaatat taataaaatt gattaacctc ttgacagaaa acaggaggag 16800
gaaaaagaga ggagttacaa tttaccaata tcggaatgag agaggtgaca tcactacaaa 16860
ttctacagat actaatggat aataaggaaa cattatagct tttctccaat aattccatca 16920
acttattaat agatgaaatg aacaaattcc ttgaaagaca caagctacca aagttcactg 16980
aagaggtagt agagaatgta aaagcccaga tctattatag acagtctcga aagttagaaa 17040
tagaagagaa cttccctagc ctgataaagg gaatctatgc aaaacgtgca cctaacatca 17100
tatttagtgg taaagcaaat agtaatataa tcgatttttt ttcttttttg agacagagtc 17160
ttgctctttc acccaggctg gagtgcaggg gcgcgatctt ggcccactgc aacctccacc 17220
tcccgggtcc aggcgatctt cctgcctcag cctcctcagt agctgggatt acaggcacat 17280
gccaccacac cctgctaatt tttgtatttt tagtagagac agggtttcac catgttggtc 17340
aggctggtct tgaactcctg acctcgtgat ccacccacct tggcctccca aagtgctggg 17400
attacaggcg taagccactg cgcccagctt tttttttttt tttttttttt tttgagatgg 17460
agtcttgctc tgtcgcccaa gctagagtgc tgtggcgtga tcttggctca ctgcaacctc 17520
caactcctgg ttcaagtaat tctcctgcct cagcctcctg agtagctggg attacaggtg 17580
cccaccacca tgcccagcta atttttttat ttttagtaga gaatgggttt caccatgttg 17640
gaccaggctg gtctcgaact cctggcctca ggtgatccgc ccaccttggg atcaccaagt 17700
gttgggatta caggcgtgag ccactgtgcc tggcctgcct agacttttaa cttatttgtg 17760
taattacttc aagtatagat tactccaatt taaacacaaa gattgtgaaa ctagatgaag 17820
aataaacata ttcaaaatga ttattaaatg ttttaattgg tgacagagtt tttcatagcc 17880
ttttatcatc tcagtgcatc atgttttatt tgtaggtagc cacagagaaa cagctacatt 17940
tataagaaca ccatgaagaa taattaaaat gttctttttt tttttttgag acagagtctt 18000
gctttgtcac ccaggctaga gtgcagtggc aagatcttgg ctcactgcaa cctctacctc 18060
ctgggttcaa gtgattctcc tgcctcagcc tccctagtag ctgagattgc aggtgtggac 18120
cactacacct ggctaatttt ttgtattttt agtagagatg gggtttcacc atgttggcca 18180
ggcttgtctt gaactcctga cctcaggtcg atccacctgc cttggcctcc caaagtgttg 18240
ggattacagg tgtgagtgac cacacctggc ctaaaacatt cttttatccc tgacttcagc 18300
tgagtttagt ttgaaatgag gctctttatt tggggtgatt gggctttgca ggagggttgg 18360
tgggtggcct ataattcccc ccaatattgt atgtaagata ttacatgttt gtatacagtt 18420
tttcaggaga gagtccgtag ctttcatcag tctctcatga ccaaaaacta tttaagaatc 18480
atggcttgaa gaatgaaaga atcgagtgcc atgttaagtg tctaatttct caataatact 18540
tccctgaaac taatttctag agaataattc aaatgacttg atctaaatat gtgtgcatga 18600
gtcatcaaag cagcctggag taacatatta aaagttatcc caagggtctg tctggttcaa 18660
actctgatga aagccctata tttcttatcc tggactgggt ttctcatagt atgattccca 18720
gatcagcagc agcatcagca tcacctagga acttgttaga aatacaaatt ctcaggccgg 18780
ccccaggcca tacctactga gttacaaatt ggagatggga ccaggaatcg gtgttttcta 18840
aggagctttc caggtgattc tggtgtgcac taaagtttga taaccactgg gttaggctat 18900
aattagaaaa tcctgttctc cgccccgctc ccaagccagg tttagaacag tttgttaagc 18960
aagtatctgc agaaagacca gtctaatgtt gacagcttct attttccatc tttatggaaa 19020
aatcgtaaag cctcaaaagc ccaaatcacc ctcacacaag tgtcttgggt tgcacagcaa 19080
caccaaacaa cagtttagag taatccaatg tccagctgaa attggaatta tagagacaca 19140
gcatgtgagt tcactcacaa aaatttttac caggaggctt tttagggatg agccccgtaa 19200
ttccaagggc cttggctctc agcctccttt gaggcatata acacagtctc ttgaacagac 19260
tgaccctcag taatgaggtt tcattaccct cttccagaca tgtggcaccc tcacaaacat 19320
cctttaacag agtgctcagt atcaccatgc ttcgtttgca aagtaactta atgaattcgc 19380
tcagcctata ttcttagtac ccagtggtag ggatctcagc tgtagcagca taaaacttga 19440
actgtccaaa accagtctct gaaaccttca agtgtttatt ctgtctactc ctgctgttgc 19500
ttgaagcttg atttgttgtt acaccttact gttttgctga tgagaaatag cacagggtac 19560
ttctcagtgg ttctcattaa aggagggcag ccaagtggaa ttcattcttg gctcttaata 19620
gttttcaaat gagaatttta ttgcatacta atgagcacta attgacattt gtgactgttt 19680
tttatggaaa taatgcatgt acaatttgca taatagtacc taagtgcttt taggtaacag 19740
tacaactctg ggaagttggt gaaggttttt gtatgatgct ttttaaaaaa gttcccaaac 19800
cccagcccct agaatagtat agaatattaa caggtctctg ggatccaaat ataaggcagt 19860
agtagtgact cagttcctgt agttgtacca gcttgtacct gagagtcaga aaatgcatca 19920
gggcaggtct ctaaaagcag gaagcgctcc cacagtagcc agggaggatg ttccagccct 19980
ctctaccttc atgtgtcaac cctcctgctt ctcctaagtc atgagtatct agacagtgct 20040
gaggattgtt ccaaggactc ctacactgta aaatgttttc taaacatcac ttggttgata 20100
tcaacaaaca tggattgatc acctactatg tgccaggcac tgtgctagat gccagagtaa 20160
gcccatgttg gcttgctgcc tgctgcatcc ctatctctta gcacaatgag gcaacagtta 20220
tccatcaatg tttattgaat taatgaacat gctgtctgcc ctcagggatc tgaggattca 20280
ttattcttac aaaatctgac gttgaataca gtataaaatt tgttgctctt catgttagaa 20340
atattaatta ttcagaactt ggaattctgt taggaaattt agagaaacaa gataatcttg 20400
gttttatgtg ccccaagttt tctgtatatc aaatgaccct tttaaatttt gtgaaaatga 20460
aagaagccaa tgtttactga agatctagta cgtatcagtt acttttgcac acatcctata 20520
catcctatga tttaagcatc aacaaaacct atgaggtgta gatagtatta tctgtgttta 20580
attgagcaag cagctaagaa ctggagaagt gactaaccta aggcatcaca gatagaaaat 20640
tgtggaactg ggacttaaat tcagcctagg ctgtgtctgt tgcactgccg cttattacat 20700
taaatgatcc taggatatgt taagcaaagc caaactctga agtattgtac tagtgatacg 20760
gctccgatga ctggaggaac actggggttc ttggtctcat gccggtttgg ataaaatgac 20820
atggacacac gtggagtggt tttagggagg gaaaagttta ataggcagga aagcaggaag 20880
gaagaagaaa acagctcccc ggtacgggga gagaagtagg gggattcaaa caaagagaaa 20940
acctcatgtg cggcagaaaa gtggctgctt atatgaggat gcaggaggag gtggtgtctg 21000
atttgcatag ggctcagggg attggtttga ccagtcatgt cattcctgca gcctgtgaaa 21060
aaactgaccc tcccacccta gctttttaat atgcaaatgc agggcgccat tatgttttac 21120
acacatgggg acatgtgggg gtggccatgt tgccaggcac atgtaggggc aagggcaaga 21180
agatggcagg aatcaccatg tttggatgga cccagtttct aatggctggc atttgcatat 21240
caaagcttgc tggcccagct cagagccggg gctttcctgc tagacaagaa acgtttctgg 21300
agctgcttta aaagaaataa aaactcccca aggacccctt ttcctctcta tctgcctaaa 21360
ataatttatt aataactcct gtaacactag gatggaggga tgaattggtc caggggtctt 21420
ggtgtgtgcc ctgcattcag ttgacctact gtttacaata cacctactgt ttacaacact 21480
attttctaga tcttgtgggg aacccaaacc aagggccagt ctggctcacc tataattcca 21540
ccaagcagcc agaaaagtat aaacgctcta cagcaaaggg ataaatcaag gtttagtaga 21600
agaaaagctt tataagtaat gtggaactaa aaggttgaat atagttttca ataatgttga 21660
gcataaatgt tctccagatt gtggaaagat cactaactgt tggctgggaa gggtaggaga 21720
ggagagagtt tgaaacacag agaataggaa ggagtggtga tgtagtccaa taactcaccc 21780
agaacccatg gacgtgaaag ctttgtttgc tctcagatcc ataactagac taaaggagtg 21840
aatcagatct gctcccctgc accccaccct gctcaccttc cacacctgcc aagggccacc 21900
cagcaattcc attctgcttg tcaaatcccc taaggaggat atgtctggaa cagccaccac 21960
tcctccccct gctcttccct ctggtatgtc aggattccct gcacaaccgt gctccagggt 22020
ccttgggatg attattcaga aaccagagaa gtatgtagaa aacttaatcg gaggcactta 22080
aaggctttaa aagggaattt taaaaaccat ctttccctct tttataaggc agtctgagta 22140
tttaagaagc aaattaattg agtccacttt acagtgttgg ggcaaaagca tgcaagttcc 22200
aacatttaca cactaacaga aaattctttt cccttccact gtgctccttt tctttcttgg 22260
gcctgctcca caaacttcta accacagtcc taaattggta ccccatgacc ctgtgtgctt 22320
cgattgccta cactggtttc agacccacgc tgtggattca aatcaaacct gcctttctcc 22380
ctgttactat gtccacccag caccctcctt gcacacacag tctttctctt ctttcctcca 22440
tgtgcagacc tttaccacag ctgtcccaaa tgtgtgaaag gccaaccata actcttcctt 22500
taaaggtcct ttagagcagt atggaaagag tgctgaactt ggaagaccta gattctcttt 22560
ctatactcat tatgtgatcc tgagcccctc acttaacctt gcagggcact tacaaaataa 22620
agagatggag ttcatgatat cttaaggtca ttttccatgt ccaacattct ctgactcttc 22680
atctttccct gactcaacat tctgttccta tatagtcaac accttcccac cttaatctca 22740
tgctcatgcc ctcttagaaa gtctttacaa ctgttgaggg tgcagtggct catgcctgta 22800
atcccagtac tttgggaggc cagagtgggc agattgcttg agctcaggag tttgggacca 22860
gcctgcataa catggtgaaa ccccgtcttt attaaaaata caaaaaaaaa aaaaaaaaag 22920
ccagatgtgg tggtgcttgc ctgtggtccc agctactcag gaggctgaaa tgggaggatc 22980
acttgaaccc aggaggcaga ggttgcagtg agctgagatc atgtcattgc attccagcct 23040
gggtgacaga gagacaccct gtctcaattt aaaaagaaaa aaaagaaaga aagcggcggg 23100
ccgcggtggc ttacacctgc aatcccagca ctttgggagg ccgaggcagg tggatcatct 23160
gaggtcaggg gttcgagacc agcctggcca gcattaagaa actctgtctc tattaaaaat 23220
acaaaaatta gctgggcatg gtggtgggca cctataattc cagctactca ggaggctgag 23280
gaaggagaat cgcttgaacc cgggaggtgg aggttgcagt gagttgagat cgtactattg 23340
cactccagcc tgggcaagaa gagtgaaact ccatctcaaa aaaaaaaaaa aaaaagaaaa 23400
tatttgcatc tgtgaactgt cttctgtgtt gaggatgttt gtggcagaag gagatagacg 23460
taggctctgt ctacgtctgc ctggtgcctc cacaaggagc agtgtatgct cagagaatag 23520
aagtgaattt tactattagt ataggtgacc catattgaaa atgtttgtaa atctgctacc 23580
agaacaacac agtcattcaa agacaattaa aaatgcattt tatacttcct gctatttata 23640
attattcatg gatctgctgc ctacagtcag gtagtaaaag gagagccaga aggaatcata 23700
gtgaacatct catacaatgc tatctttgtt gttggtttga acataagcat ttttgcgtga 23760
atttgcgtgt aggtctcttt tatttctctt attgcataac ctgaggctga aatacttcaa 23820
gtaatgtatc tatttgctca tattgggtag aaacatccct attattccaa ttttcccttc 23880
tcctgcttaa aacatatagt gaaatgaaag atgcagagat aaggaaatca gggaaaagaa 23940
aaatagtcat aggatactaa aatgagccac agatacctga aactgcatag ttgctataaa 24000
tgagccataa atttgattct gagctttcca gtggccccaa aaagataaac ataatagtat 24060
ttattccatg acataaaaat gtatttgtat ttctctgtgt tcaagaggaa gagaaatttg 24120
tactatgggt cctcatgaag gagccactaa gtcagtgttg tagaccacac attcaacgat 24180
atcgtattaa tacccatgat gatgaattca ttcattcaat aagcatttat tgagtactta 24240
ctttgtgctg tatatgtttc agtgtattgc agtaattatt ctttttgatg ctcaaattgt 24300
cctattgtgg gtcagtagga gcccgttgat tcatgtcctt ttgacattat tctgtagttt 24360
ttgatacttt ttttcctagc atgatgagat gttccaggct tatgtcgtat atttcttgtt 24420
ccgtaactca aattgaccat tttgttaatg aaacttgatt tttttcagtg aaaagtggtt 24480
ttatagaaca caatctgggc acttgaagtg tttattgtta ctgggttgtc attacttaca 24540
agactcagtt aacaaattag gaaaaagatt gatttagaaa gaaaataaat cctgagttca 24600
tattgttatt tccaatttaa agattaaagg gttttcgtat aacttatttt atatgtgtat 24660
gtcttttctc ttactttgaa atcttggttt ccaataacat gaacataatt acttccttta 24720
tcctaatagg tacgtatatg tgtatatgtc tatgtatgta tgtatgtagg tatgtatgtg 24780
tgtatgtttc tatctgtaaa acaggaaaaa tacccaccta atggagctta agatttcttt 24840
atgagtattt tttgtcctta gggtatttaa tcaaattact gttacttaaa ataatgtttc 24900
tctatgtggt tatgccatca acttcatata caattatttt atttcaattt gtcttcgatt 24960
tttaaggatg gttttcttct tctgatttaa ttttgttttt aaattatgta aaatattttc 25020
ttggtttcag agtcaaatct atgaacattg agaggtctat tttgcctctc tgtcccctcc 25080
cccttattat tttactcccc ttatagataa tgcttttatt tttccattac tttttttttt 25140
tttttttgga gacaggagtc tcgttctgtc acccaggcag gagtacggta gtgtgatctc 25200
ggctcactgt aacctccacc tcccaggttc aagcaattat cctgcctcag cctcctaagt 25260
agctgggact acagacactg accaccatgc ctggctaatt tttgtatttt tagtagagac 25320
agggtttcac tgtgttgatc aggctggtct caaactcctg acctcaagtg atccgcctgc 25380
cttggcctcc caaagtgccg ggattacagg tgtgagccac cgtgcccagc ctctattact 25440
ttttgaaaat aagccaatga cctatatgta tcctatctcc tttcttacac aaaaggtagc 25500
aggccagagt tcaagattac agtgagctgt catcatgcca ctgcacttta gcctgggcaa 25560
cagagtgaga ccttatctct aaagaaaaac aaacaataaa aaattttaaa aataatttct 25620
atgaattaaa aataatttta aacacaactg catatgaaga caacaaagga aaactctcag 25680
gaaacactga aatatgaaaa tcaagtgaga ttagagcaaa taaggatgtg tatgggaagg 25740
ttctgtagaa gacagattga ggcccaaaca gagagagctc taaatacatc atgaaggtta 25800
ccagaaatgt gagaaattcc tgaagaagag ggaagaagca aatcctctcc aaatttagtt 25860
cacttagttg ataatcatta gttgattccc agtagagtca gtcttttatc atcagtgcca 25920
ccactgttgt tctctgcatt aacaaaggag atattaatct ggaaagctgc aatcattttc 25980
actgtagaat cagcctttta ttttttaggg ttttttaatt tttttttttt aggacacctt 26040
catttaagat cacttcatat ctcctctggc ttttgcaaat gctctttggc tgatctactg 26100
tttccaccac tgtcctcaac attttttagt atattattta atttatgtat gtattggtgt 26160
ccactgatta ttgtttgcct tcccccattg gaacacagat tctataaaag tagggatctt 26220
tattttgttt accactgtat tccaggtgcc tagaacagtt cctttcacat tgttggtgct 26280
caaaaagaaa aaagttaaat gaatgaatat cagcagcaag agcattttga ggagaaagca 26340
aaggtgtaac tgtgggggtc tccattaatg tatgtatatc atcctcttat acatttgtcc 26400
catcacccgc tagccctgga actctcatta tttttttttc tggtaatgca ggctccaact 26460
caactggcaa tgagaatatg aactgaggca actgtatttg aaaaatgaaa gaatataggt 26520
gatatgggtt taaagaattc agtatttgtg tatttttcca ataagtacat gcttatgagc 26580
atagccttac aaaataacaa aaataatttt ttacatttac tcacacactt accatttcca 26640
gcactcttca ttcctttgta tagatccaaa tttgtatctg gcatcatttt acttctgcct 26700
aaagaactaa ctctaacatt tttttatagt gcatgtctct cagattttct ttgtctgaaa 26760
attactttat tttaactcca tttctgaaat acattttcag tgggtattgt attctgggct 26820
gacttttttt ttttttccca gtgcttgaga gatgccattc cattctcttg tggctttcat 26880
tatttttgat gaaaaatcag ttgtaagtct tactcttgtt cctctgtaca taatctgact 26940
gctgcttcta aaattttatc tttattgctg gtttttagca atttctgtgc cttgttttgt 27000
ttttgttatt tagtgtttgt tctgcttggg attggttgag cttggatctg taggtttata 27060
cttttcatca aatacgaaaa attttggtca ttatttttca aatatttttt ctactcctcc 27120
ctcctcactt tttccccctc aaacagcagt tacatgtatg tcagacaact tgctattatt 27180
ctataagtca ttgagacaat gttcattctt ttttattttt aatttttgtg ggtaaatagg 27240
tgaatatatt taggggttca tgagatgttt tgatataggc atgcaatgta aaataagcac 27300
atcatggaga atggggtatc tattccctta agcatttatt ctttgaatta aaaacaatcc 27360
acttacactc ttatcacttc tcagcctttt gggataagat catgtgtaaa aacaatgtac 27420
ttacactttt cattttaaaa tgtacaatta agttattatt gactatagtc accctgttgt 27480
actatcaaat agtaagtctt actcattcta actaattttt tataaacttt aactataccc 27540
acttctcctc ccacctccca ctccctttcc aacctatggt aaccatcctt ctatactctg 27600
ttcatgagtt cacttgtttt gatttttaga tcccacaaat aaataagaag atgtgatgtt 27660
tgtctttctg tgcttggctt atttcactta acgtaatgat ctccagtgcc atccatgttg 27720
ttgctaatta ctggacctaa ttcttataca tggatgaata gtacatcatt gtgtagatgt 27780
accacatttt ctttattcat tcatctgttg atggagactt agattgcttc caaatcttag 27840
ctatagtaag caatgctgca acaaacagga gtgcagacat ctctttaata tactgctttt 27900
ctttcttttg ggtatatatc cagcgatggg attgccagat catacagtag ctcaattttt 27960
agttttttga ggaacctcca aactgttctc cataatggtt gcactaatgt acattcccac 28020
caacagtgta caagggtccc tttttctcca catcctcacc agcatttgtt attgcctgtc 28080
ttttggatat aagccatttt aactggggtg agaagatatt ttagttttca tctgcatttc 28140
tctgatgata aatgacattg agcatctttt catatacctg tttgccattt gtctgtcttt 28200
gttggaaaaa tttctgttag ctcttttgcc cattttttta atcggattat taaatttttt 28260
cctatagagt tgtttgagct ccttatatag tctggtgatt aatcctttgt cagatgggta 28320
gttggcaaat attttctgtc attctgtgag ttgtctcttg actttgttga ttgtatcctt 28380
tgatgtacag aggctttgta acttgatgtg atcctatttt tccatttttg ctttggtcgc 28440
ctgtgcttgt ggcatattgc tcaagaaatg tttgcccaga ccaatgtcta gagactttct 28500
gcaatgtttt cctgtagtat tttcatagtt tgaggtctta gatttaagtc tttaatccat 28560
tttcatttga tttttgtata tggtgagaga tgggtgtcca gtttcattct tatgcatgtg 28620
gatatccagt tttcccagta ccatttattg aagagaccct ctctttccca gtgtatgttc 28680
ttggcacctt tgccaaaaat gagttcactg tagtttctgg gttctctctt ctgttctatt 28740
ggtctgagtc tgtttttatg ccagtactat tctgttttag ttacaatcat tctgtagcat 28800
aatttgaagt caggtaatgt gattcctcca gttttgttct tttcactcag gataccttta 28860
actattctgg gtcttttgtg gttccacata aattttagga ttgtattttc tatttctgtg 28920
aagaatgtca ctggtatttt gatagggatt gcattgaatc tgtagattgc tttgggtagt 28980
atggacattt taacaacatt gattcttcta atccatgtat atgggatatt tttccatttt 29040
tggtgtcttc ttcaattttt ataatctgtg ttttatagtt ttcattatac agatctttca 29100
cttctttggt caggttaatt cctagatatt taattttatg tgtggctatt ataaatagga 29160
ttacattttt atttcttttt cacatagttc actgttggca tatagaaatg ctactgattt 29220
tttataaact tttatgttat gttcaggtgt ataggtacag gtttgttata taggtaaact 29280
catgtcatgg ggtttgtcgt acagattatt tcatcaccca ggtactaagc tagtacccat 29340
tagttatttt ttctgatcct ctccctcttc ccactcttca ccctcagtag gccccagtgt 29400
ctgttgttcc cctctgtgtg tccatgtgtt ctaatcattt agatcccact tgtaagtgag 29460
aacatgcagt atttggtttt ctgttcctgt gttacttttc taaggataat ggcctccatc 29520
tccatccatg ttcctgcaaa ggatataatc tcattctttt tatggctgca tagtattcca 29580
tgatgtatat gtaccacatt ttcttttttt ttcccttcaa cttttatttt aagttcaaga 29640
gtacatgtat gtacaagatg tgcaagtttg ttacataggt aaatgtgtgc catggtagtt 29700
tactgcacag atcatcacat cgcctaggta ttaaggccag catccattag ctattcttcc 29760
tgatgctctc cctccctcac cacaccccct ccgacaagcc ccagtgtatg ttgttgcccc 29820
ctcacatgtg tccatatgtt ctcatcattc agctcccact tataagtgag aacatgtagt 29880
gtttgggttt ctgttcctgc attagtttgc tgaggataat ggcttccagc tccattcatg 29940
tccctgcaag gaacatgatc tcattccttt ttatggctgc atagtattcc atggtgtata 30000
tgtaacacat tttctttatc tagtatatca ttgatgagca tttaggttga ttccatgtct 30060
ttgctattgt taatagtgct gcagtgaaca tatgtgtgca tgtatctttg taacagaatg 30120
atttatattc ctttggatat agacccagta atgggattgc tgggtcaaat ggtatttctg 30180
cttctaggtc tttgaggaat tgccacacta tcttccacaa tgattgaact aattcatact 30240
cacaccaata attccttttt ctccacaaca ttggcagctt ctgttgtttt ttttgacttt 30300
ttaataatag ccattctgac tggcatgaga tggtatctca ttgtggtttt gatttgcatt 30360
tctctaatga tcagtgatgt tgagcttttt ttttcatatg tttgttggcc agatgtatat 30420
cttcttttga gaagtgtctg ttcatgtcct ttgcccactt tttaatggtg ttgtttgttt 30480
ttcttgtaaa ttggcttaag ttccttgtag actctggtta ttaaaccttt gtcagataga 30540
tagattgcag aaatttttct cccattcttt aggttgtctg tttgctctaa taatagtttc 30600
ttttgctgtg cacaagctct taagtttaat tagattccat ttgtcatttt tgctttcatt 30660
gcaatcactt tcggcatttt tgtcatgaaa tcttttcctg tgcttatgtc ctgaatggtt 30720
ttgcctagac tttcttctag agtttttttt tatagttttg ggttttacat ttaagtcttt 30780
aatccatctc cagttaattt ttgtatgtgg tgtaaggaag gggtccagta ttaattttct 30840
gcatttggct agccagttcc cctagcgcca tttgttaaat agggaatcct ttccctattg 30900
cttgtttttg tcaagcttgt caacagtcag atggtggtag gtatgtggtc tgatttctga 30960
gctattttgt ttcattggtt tatgtgtctg cttctctaca actaccatgc tatttgggtt 31020
actgtagcct tgtactatag tttgaagttg ggtagtgtga tgcctcaagc tttgttcttt 31080
ttgcttaata ttgccttggc tattagggct cttttttggt tccatatgaa ttttaaaatg 31140
attttcttct aattctgtga agaatgtcaa tggtaattta atgggaatag cattgaatct 31200
ataaattact ttgggcaata tggccatttt catgatattg attcttccta tccatgagga 31260
tgaaatgttt ttccgtttgt ttgtgtcttc tctgatttct ttgagcagtg gtttgtagtt 31320
ctccttgaag aggtccttca cttcccttat tagctgtatt cctaggtatt ttattctttt 31380
tgtagcaatt acgaatggga gttcattcac aatttggctc tctgcttgcc tgttgttggt 31440
gtataggaat gctagcaatt tttgcacatt gatgtttata tccttagtct ttgctgaagt 31500
tgcttatcag cttaagaagc ttttgggctg agacaatggg gttttctaga tataggatcg 31560
tgtcatctgc aaacaaagat aatttgactt cttctcttcc tatttgaata ccatttattt 31620
ctttctcttg cctgattgcc ctggccagaa cttctaatac tatgttggat agaaatagtg 31680
agatagggca tccttgtctt gtgccagttt tcaagggaat gcttccaact tttgcccatt 31740
cagtatgata ctggctgtgg gactgtcata gatggctctt attattttga agtatgttcc 31800
ttcaatacct agtttattga gagcttttaa catgaaggga tgttgaattt tatcgaaggc 31860
cttttctggg cctattgaga taatcatgtg gtttttgtct tttattctgt ttatgtgatg 31920
aatcacattt attgatttgc atatgttgaa ccaaacttga atctcaggga tgaagccaac 31980
ttgatcgtag tggatacgct ttttgatgtg ctgctggatt tggtttgcca gtattttatt 32040
gaggattttt gcctcaatgt tcatcaagga tattggcctg aaattttctt tttttgttgt 32100
tgtatctctg ccaggtttgg tatgaggatg atactggcct caagaatgag ttagggagaa 32160
gtccttcctt ttcaattttt tggaaaagtt tcagtagaaa tggtaccagc ttttctttgt 32220
accgctggta gaattcagct gtgaatctgt ctgatcttgg gctttttttg gttgttaggc 32280
tatttgttac tgcctcaatt tcagaacgtg tcattggtgt attcagggat tcaatttctt 32340
tctgcttcag tcttgagaag gtgtatgtgt ccaggaattt atccatttct tctagattct 32400
ctagtttatg tgcatacagg tgtgtgtagt attctctgat ggttgtttgt atttctgtgg 32460
gatcagtgat gatatcccac ttaacatttc tgattgtgtc tgtttgattc ttctctcttt 32520
tgttctttat tagtctagtt agttgcctat ctttttatta attttaaata aaacagctcc 32580
tggattcatt gatttttttg aaaggttttt tgtgtctata ttttcatttc aactctgatc 32640
tgatcttggt tatgtcttgt cttcttctag ctttgaaatt tgtttgcttt tggttctgtc 32700
attcttttag ttgtgatatt aggttgttaa cttgagatct ttctagcttt ttgatgtggg 32760
catttagtgc tataaatttt cctcttaaca ctgcttcagc tgcaccccag agattctggt 32820
atgttgtctc tttgttctca ttagtttcaa ggaatttctt gatttctgcc ttaattttgt 32880
tatttaccca ggagtcattc aggagcaggt tgttcaattt ccatgtagtt gtgtggtttt 32940
gagtgaattt cttaatcttg agttctaatt tgattgtgct gtggtcagaa agactgttat 33000
gatttcaata cttttgcctt tgctgaaaaa gtgccatgtg gtgatgagaa gaatgtatat 33060
tctgttgttt ttgggtggag agttctgtag atatctatca ggtcctcttg atccagagct 33120
tagttcaggt cctgaatatc tttgttaatt ttctgtctca gtgatatgtc taatattttc 33180
agtggagtgt caaagtattt cactattatt gtgtgggagt ctaagtctct ttgtaggtct 33240
ctaagaactt gctttatgaa tctgggtgct cctgtattgg gtgcatatat atttaggata 33300
gttagctctg cttgttgaat tgaacgcttt accattatgg aatgcccttc tttgtctttt 33360
ttttatcttt gttggtgtaa agtgtgtttt gtcagaaact aggactgcaa cccttgcttt 33420
tttctgtttt ccatttgctt cataaatttt tctccattcc cttattttga gcctatgtgt 33480
gtctttgcac ttgaggtggg tgtcttgaag acagcatact gatggccctt ggctgtttat 33540
ccagcttgcc attctgtgac ttttaattgg gggcatttag cccatttata tttaaggtta 33600
gtattgttat gtatgaattt gatcctgtca tcatgatgct agctggttat tttgctgact 33660
tgtttttgtg gttgcttcat agtgtcactg gtctgtgtac tttagtatgt ttttgtagta 33720
gctggtaaca gtttttcctt tccatattta gtgcttcctt caggagtgct tgcagggcag 33780
cctggttgtg acaaattccc tcagcatttg cttgtctgaa aaggatctta tttctccttc 33840
acttatgaag cttagtttgg cccgatgtga aattctggat tggaaatatt tttctttaag 33900
aatgttgaat attggtttcc agtctcttct ggcttgtaga gtttctgctg aggagtccac 33960
tgttttctgt tgggcttccc tttgtaggtg acctggactt tctctctggc tacccttagc 34020
attttttttt tcattttcac cttggagaat ctgatgatta tgtatcttgg agttgatctt 34080
cttgtggagt atcttactgg ggttctcggc atttcctgaa tttgaacttt ggcccatctt 34140
gctagcttgg agaagttttc ctgtatgcta tcctgatgca tgttttccaa ctcagttcca 34200
ttctgcccct ctctttcagg taccccagtc aagtcatagg tttggtctct ttacataatc 34260
tcatatttct ctgaggtttt gttcattcct tctcttttta tttgtttctg tattcttgtc 34320
tgcctgtcta tatgcagaaa gatagtgttc aagctctgaa attctttcca ctgcttggtc 34380
catcctatgg atacttgtga ttgcattgtg aagttcttgt gtattacaag aactttattt 34440
ttttatcttt atccagtcta ccattgatgg gcatttaggt tgattctatg tctttgttat 34500
tgtgaataat gctgtaatga acatactaga atgattcatg tttatttggg taaatgtgtg 34560
ttgatttcgt atcctgcagt tttattgaat ttatcagttc taatcatttt tcttgtggag 34620
tctttaggtt tttccaaata taagatcata ttgtctgcaa acaatgatca tttgagttat 34680
tccttttcaa tttggatgct ttttatatct ttctcttatc taattgctct agctaggact 34740
tccagtagta tgttgaataa cagtgatggc agtgggcatc cttgttgtgt tccagatttt 34800
agaggaaagg ctttgtcctt cccctatgcc ccaggtaggt ccaggagtca aggactagag 34860
tccaaaacct tagaagtcta cctggtattc tattatactg tggctgagct ggccctcaga 34920
ccacaagaca cagtccttcc cactcttctc tcccctttcc aaaggcagag gaactgcctt 34980
tagtagagac agggtttcgc catgttggcc actgccaacc cagcccatga ggaggactgc 35040
cagactactg ctgatgttcc cttaaggccc aagttctctt aaatcagctt gtcctgaatg 35100
ttacctagcc tgagactcac ccttcaggac agtgggctcc cctctggccc agggaaggtc 35160
cagaaatgct gcccaagggt caagtcctgt aatcagggac tccaagagcc ctcttggtat 35220
tctaaccccc tgtatctgtg gtggtaccta aggtgcaaga caaagtccct tttacatttc 35280
cttctgcttt tatcaagcag aagttttgtc ctgcagccac cacagctggt aatgtactga 35340
gttctacctg aagccaggaa gtctcagagg ctcacccaag gccctcaaca tagtccctgg 35400
ttattgctgc tggttattca gaaccaaggg ctcttcactt agcaggtgat aaatgccggc 35460
agggctgggt cctttccttc aatgcagtgg gttccctctg gcccagggtg tgtctagtaa 35520
tgtcacctgg tttctagggc ctagaatgga ggcctcatga ctctgaccag tgccctatcc 35580
tgctgtggct gcgctggtat cctagacgca agacaatggt ctccccactt ctccctctcc 35640
tattctcaag tggaaggaag gggtctcttt tggagctgta agctgtgtag cctggggtaa 35700
ggggaggggt gatgccaata ctctcttggc tgccccagct ggtgtctcag taggttgcat 35760
gcactcccag tctgctgtct ctgggcctag ttcagcacca ggactcacct aagagttgca 35820
gtccttatgg cctagactgc ttttgaagtt tacttggaga caaagagcac tgtggccttc 35880
actggtgagg tttacaggca ctcaagttta gaccactggg attggtgatt cttctctggc 35940
tagggctgtt ttaaatcctc cctccgtttg cacatttcag ctgagtttga tctagtttgc 36000
ctttctgctc tgatttctgg ttcttatgaa ggtgtttttt tctgtgtaga cagctgttaa 36060
cttggtgtcc ttgcagaggg aatgatcagt ggagccttct atttcgccat cttgatccgc 36120
cgccatatat cattcttatc aatcattttc tgtttatgca cctgaaaata cactggtata 36180
caaaattaag atccttactt tcacagaatt tgtgttctaa tgggggaagt caataatcgg 36240
tggacaccaa tacatatata aattaaataa cacattaaaa ggtgttgagg acatgctggg 36300
catggtggct catacttgta atcccagcac tttggggggc cgaggcgggt gcatcacttg 36360
agatcaggag tttgagacaa gcctggccaa catggtgaaa ccctgtctct actaaaaata 36420
caaaaattag ctgggtatgg tggcaggtgc ctgtaattcc agctactagg gaggctgagg 36480
caggggaatc gcttgaagct gggaggcaga ggttgcagtg agctgagatc ctgccactac 36540
actccagcct ggacaacaga gtgagactct gtctcaaaaa aaaaaaataa ataaaaataa 36600
aagctgttga ggacaatgga ggaaaaggca gatcagagaa agaacattta caaaagccag 36660
agggagtgtg aagcaatttt aaatgaggtc agatttttgg ataatttcta ttgctatgtt 36720
tttaagttaa ccaatgtttc tttttgcaat gtctgatctg ttacattttt atttcagata 36780
ttatattgtt atctctagaa gttctattta gatctccttt ttatctttca attctctcct 36840
cattttgttc atattttgct ttatatccta gagcatattt ataatagttg ttttaaggtt 36900
cttgtgtgat agttatatca tttctgttat ttctgtgtct gatattattt atctattttt 36960
taaaacttta tgggtatagg tcatattttt tcatttcttt gaatgcctgg tgattatttt 37020
gaattttaca ttgttgagca ctggatgttg ttatattcct tttaagagca ttgagttgtg 37080
ttctggaatg cagttgagtt tttacagatc actttgatcc atttgagact ttcctttagg 37140
gtatatccag agtaacatct agtttagagt taatttgttt ttactactaa gatgtggctt 37200
ttctgaggat tttatccaat gtcctgtgta ttttggggtc tctccacact ggctgatgga 37260
aacacagggt agtctcagcc ctgtgtgagc tccaggaatt actcagctat tgcctatcag 37320
tgtttttttc ttcaactcca agtagtttct tccagctcat atccaaatca tacttaggag 37380
aagactgggg gggatcctct gcagatttcc aaagtgctct ccccactctc tgtatctccc 37440
tcttcttcat tactctgtcc cacaaattct aaccacctca acatccttaa attccaatcc 37500
attccccctt acctcaggta gaattctagg ttctgattgg ttttccctcc acgtgctgtg 37560
acctggaaat gacctccagg cagtatctct taggaagccc agttgtgtgg catctgttgt 37620
acaatgcctg aaaatgattc tttcatgtgt tttgtctggt tttcaacttg ttcacagaaa 37680
aaagcaattt gcacagcagt taattcttca cagacagaag cagaagttct accaactgca 37740
aaacaaccaa aacaacttgt taaaagacag tatttgtatg actggtcata aattacgtat 37800
agaagaatag agattttgtg agaaagatat gggcctgtac agaggggtga acttgcaaat 37860
gaccatcttg cttggggata gtgtctgttt tcctgatcct aatcactggg aaggattctg 37920
taatctctgt caaataaatt gcaaacacta ccacacatgg ccttgggtct actactgtct 37980
atgacataaa cagtttctcc ctagagactt agttgtgagg gtacaggggg aaggtagctt 38040
ttggaggggc ctggaagacc cttccctttg tgccttcgat tctgtatata tcttgtggtc 38100
agaagtctta ccattaccct ctctgataac tccccaccca ctttcccaat cactaaacac 38160
tttttgaaac cattcaactc tttcctttca atgattgagc ccttcattgt ttcatcagct 38220
cctcttgtgt gaatctctct gaatgtgtgc caagtttgca gtttaatgcc tgtcccatgt 38280
aggagcccaa tatcacggta tataaagttt ctacactgga tatccatgga ctgaagaggg 38340
gcctagcatt cagggttcca agccagtgag tttagcttat ccaagggtac ctctagaatg 38400
tgctcagaaa tttattccaa gtcagagttg catcccccag gactttaggc tcagatggac 38460
aaccccatca tatttacaga atccctcaaa gataatttaa gtttaagatt gtcagcccac 38520
ctggggtgca cagtgttgac cagggtttct taaccttagc actgttgaca tttggggcca 38580
gataattctt tgttgttcag accatcctgt gaattatagt atgtttagca gcatccttgg 38640
catctaccta ctagatgtga atagcatcct tctcttaatt ttgacaacca cagatgtctc 38700
cagaattgcc aaatgtcccc taaaggtgca aaattgcata gttgagaact actggtaaag 38760
aggcactatg gcatgccaag ctctagggag cccacagaag tgcacctctg ggaactaaag 38820
ctgaagaaac ccaagaggcc ccttggtatc ttcttggaag aagttagtcc agagtgtctg 38880
caccatgtgg agtgtatact gggatgacat tgaccttgga atgtaaactc ctgggattct 38940
tgcctctgca gatttggagc agggttttct tcttctctgc ttttcagttt acttatttga 39000
aaatgaggaa tggtgtttac atcacaaaac actgtagtga ggacaaaatg aggttttatg 39060
tatatataca cccatacata tacatataca cttcttccaa atgatataat aatatataaa 39120
cattgaatga ataatggttc aaatataagt gtacttattt gccactatga ttaaaagggc 39180
aatataggaa aaatacattt tcttctaatc catcatgttg taataatcct ccctgtggtt 39240
gcagtatggt tctgtgctag aaggcacaat aggaaatctc taactttaaa aaaaaagaaa 39300
agaaaaaata tctttctagc aattaaaatc tcaactaaat tagaatgcaa ataggttttt 39360
atatttgctt cttaattttg cattcaataa tctgactaga atatgcaata atttaaatgc 39420
cttgatggga gatagtggct tttagttctc ttgggatttc attgtaataa acctggtaaa 39480
taattcagga acatatgaga ggccaatgaa tggtcagcac ctggtgctat attatttgtg 39540
cctaagcaca cagactccaa agatggcact ctccacctgt cactgttgtt ctggcttaaa 39600
catgggccct gtgttcagtg gctattgaga taatagtaat ggatattttt gccttgtcca 39660
attttcctcc acaatcaaag aaaactgtgc taagctgttt aaaaaataca aagcagaagt 39720
ggcagcctct tttagattac cactggtaaa atttcaaatc tattttctct attaagggat 39780
tgattgtttt aaagaattag ggatatggct atcttttcta ctggtgctaa tttgagcctt 39840
tttgcctttc tgtctttgtt ccacaaggct gagcttctct ttagatcaca ttattcatat 39900
tgcaaggatc ttctgagaga aataacacca tcctctggcc agccactcac tctgcaggag 39960
ttcctagagc tccccagttt ctttccctat tgcctgagta gtctatctca cgcctgttag 40020
tctcacagtt taaatacaaa cacacaaaga ctcttgcagg cagcttgggt acctttcttt 40080
gaccccagcc gactggacat agagaacaag agctagagag aacaagagct agagtgaccg 40140
acagatcatg tgtggagaca gcatggggca cctgagccca gcaccatcca ggatcagaca 40200
gaacttaagc catgagctgc ctagaaagat cttgggaggg cactgggttt cccagtatgg 40260
aaaaaagaaa aatgtggctc acaagtctaa gctaaggtct ttacagtact gggccataaa 40320
caggatctga aaagaaactg cagaaaatgt tagatatgct ttatctttgt tttaaaaata 40380
ttatttacta taatggctta aaatatgttg atttaaatat atgatatttg atacctttgt 40440
aatatatata ataaagtgta taataaaata taactatata attaaaatag atgatatttt 40500
aaaacctctc taataaacca tttacgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 40560
tgtgtgtgtg tatacatgcc tttgtttaac aggtttaatt gctttccttt cttcaggaac 40620
cagagtgagg gtactcgaac agtgactgcc atctggtggt taaccagaat catcaccttg 40680
tgtagcctga tggttactaa gatgtccact cttgactcac atggcatgca ctcgcagcag 40740
gggaccagtt gaaggatgtc tgactttgga gggtcaccag ttgaaggatg tctgatgaag 40800
gagcctagcg aaataaccct ttgcttctac ctgaatgggt tgttcactct ggattctgag 40860
cctgcagcca gctccaaaat ggggcctctg aagaaaagat ttgagttgct cttgtgtctt 40920
agtcaaagat ctacatccct accagtgggt aaccaagact gtgaataagc acacaccaac 40980
aggggcatgt ggtgacatgg agcctgaaat aaactgctct gaattgtgtg acagttttcc 41040
tggccaggag ctggatcgga gaccccttca tgatctctgc aagacaacaa ttgtaagtga 41100
gcagccacag gatgccaggg ctgctcagat gtatgtggtg gtggtggtgt tggggaggag 41160
gaggtggagg gaaaggggga tgaggaaggg gaggagtggg aggagaaact gctcatgcag 41220
gatacatatt tcccagcact tggtgacgat ggggcagttt gtttttgacc tatagaagat 41280
ccttcattcc taacagctcc tccttattct gtcctcagac atcttcccac cacagcagta 41340
agaccatctc ttcattatct cctgtcctct tgggtattgt ttggactttt ctcagctgtg 41400
gacttctgct gatacttttc tttcttgcct ttacaattca ctgcaggaag aacaggtaag 41460
cagcccagtt tctcatcaca catagctcaa tcatgaaatc ccaaatgtta gtatcttttg 41520
gcagcacaag ccactatctg gtctcccact acaggattaa accacatgag acattccctc 41580
tgaaatagtc tacctgttga gaaggggaaa gatctaggtc ggtattgtgc taactactgc 41640
aagggtatcc aaagaagaga atgaagagtc tctctctata atggaggtac aatccttctg 41700
agaagatgag gtatctgtat ttaaaatgaa gaccatgtag aggattccaa aacaacacaa 41760
aaacttgagg acagcacagc agaaccagtc tgggtgagtt agggtttctg caaaagcagt 41820
gaagcactgc tacctggcta tttgctagat aattctggct gactagaaag tcatcagctt 41880
atcagggtaa gtatggctcc caggattcgc aaaagaagca aaatggtgac ttttttctga 41940
agggacttat agcaccttgc cttggatgca atttcatcct tcctcagggc ccatcccatc 42000
tctcccaccc ccacactgta ccctcatcct accacagccg tcccagggtg cctcatgaga 42060
agccctgctc cagccctctc cttagcccac agctgacttc tagatggagc ccacaatcag 42120
aaattaacaa cttcctcaaa ccagccaaac tcgtccagcc ccactccagc cttaccctgt 42180
gtggtgacca agcatgtcgt gctccattgc ctgtggattt gacactcaga tgagaattgg 42240
tcagttgcat tttgggatgc tgttttgcca tgttaggcat ggaggacgtg gaattgttaa 42300
gcagcagtga ttggttgttg ggtcagcctc agcatggtgg tgatacgtgg cactccaact 42360
agagtatacc ccagagactg cctcagccac ttttcattct gttcctcaag cacactacgc 42420
tgactcccat ctcaaggctt ttgtacttac tgttcctgta ctgttccctc tgcctggaag 42480
tcctcctcag atattcccat gactagttcc ttctcatctt ataggtcttg gctccagtgt 42540
cacctcttca gagacacctt ccctgatcat cctatctaaa gtagtatccc tacccatgat 42600
caccccctca tctcattcca tatcctatca gcctgtttta tgttccttat agcaagcata 42660
gtctgctatt accatatttg ttgatttacc tgttgattgt ctgtatcccc taccagaatg 42720
gaattctgtg aacacaggga ctttgcctgt cctcttgtgc ccaccactgt gtctccagca 42780
tttagaacag actctgggat ataataggtg ctcagtaaat atgcatccag tgatcctggg 42840
aggaaagaga tttaaatccc aacggtggct gctgccaaca aagtgactgg gaaaatcatg 42900
catttcaagg ttagagaact atggagtaca gtcttttcag ctgtaacatg tttctataat 42960
gcaaagtaat actcaattgg tattacccag ttggtaataa gaaaattatg tcattgattc 43020
atatgttact tttcccccag caaatcaata atttaaacat tcaggggcaa gctttctcac 43080
agctagtaaa ggaagcttta agcttggcag ttccttccct tggtgcaagt agtgtctggc 43140
ttaatggctt aagaacttgt gtcttcccta caagatgagg ctgtaggagt agatgaagaa 43200
gtggagaaga catttgcctt atgtttaaaa acttcagttg attgttaaag aaagcacaga 43260
tccagagcag atttttaatt ttttgacaat gttatctact ggagatgaat gcccctgagg 43320
acctgtgtct tgagatttaa gactgtagaa gttgactttg atcctgggta caaatgctag 43380
tggacattta ctgggtggta gtgttttagt tggaataatt aatattttat taatactctt 43440
gttacaaagt taactgtttt gagtgttatg accccatcct attttcccca cagtctatta 43500
tttttacata taattttgca gaatacaagg tttatcaagt atttatatat cctgttaaaa 43560
caggaacacc tgtaaacagc attatactag aaacccttat atttctttca ctctattaaa 43620
tattttgctg cctgttttgt ttgcagtggg agcatgactt ggcataaaga ataaaatatt 43680
aagaggtatt gtgaataaaa acacatttta caattaagtg gcttacaagg tcagacaagg 43740
aaagataaaa taacccagtt tcaaaagtgt tttattgaac aatacatttg ttaaaagatg 43800
cagcatcaca atcagatgct ttatttcgtt acaattctgt ggtctctaaa tttgggactg 43860
tgtgtgtgag tattcatgtg tgtgtatatg caagaaagga gaggaagaaa aatattttaa 43920
cacaataaaa ataatacaaa aatgtttaaa tccagttgca gatattgaat ttttataaaa 43980
atttcaaaaa ccagtaaaga taaagaaaac ttgaacacta tcaaccaact tgacccaatt 44040
gacatttata ttacctttca cccaacaaca gcagaataca tattcttttg aagtacacat 44100
ggaacattta ccaagatata tcatattctg ggccatagaa aaagtctcat taaatttaaa 44160
agggttcaag ccgggtgcag tggctcatgc ctgtgatccc agcactttgg gaagctgagg 44220
cggatagatc accagaggtc agcagtttga gaccagcctg gccaacatgg tgaaaaccca 44280
tctctactaa aaatacaaaa attagatggg tgtggtggca tgcacctgta gtcccagcta 44340
cttgggaggc tgaggcagga gaacccggga ggcagaggtt gcagtgagct gagatcatgc 44400
cactgcactc cagcctgggt aacagagcaa gactctgtct caaaaaaaaa aaaaattaaa 44460
ggattcaagt catataaact atgttttctg acaatgaaat taaaatggaa atcaataaca 44520
gaaagatctc tggaaaatcc tgaaatattt agaaactaca tagaacactt taatccatgg 44580
tcaaaaaaga aatcaaaagg aaaactagaa aatattgacc agaattaaaa tgaaaataca 44640
acctagattt gttggatgcc actaaagcag tattaggggg aaatctagag aactaaaccc 44700
catattagaa aagaagaaat gtctcaaatc catgacctca tcttccacct tacaaacaga 44760
aaaaaagagc aaatgagacc caaagtaagt agaagaaagg aaataataaa gatcaggtta 44820
gaaaataaaa taggaaacag aaaacaatag gaaaaaaaag tcagtaaagc caaaagctat 44880
gaagataagt aaaactgatc aacctctagc caaagtgatc agaaaaaaaa gaaataagat 44940
acaattaccc aaataaggaa tgggagaggt gacatcacta tagattctgt agatatgacg 45000
gataaggtaa tgttgtaaac aactatggta gatagcctct aagatgttct tcgatgattc 45060
ccacctcctt gtagtcacac tcctatgaag tcctctctcc ttgagtatga ggtgaactta 45120
ctaacttgct ttttagtgag atgtcgcttt tggcattagt tcacaaaaac tgtggcttcc 45180
accttagagc tctctcattg tcccactaac tcccactctg tgggaggcca gctgttgtgt 45240
tataagctgt cctgtaaaga ggcccccatt ggcaaggaac tgatgtttcc agcctgcagc 45300
cagcaagtac ctggggcttg ctaacagcca tgtcagtgaa ctttgaaaca ggtgacacct 45360
tgactgtatt gttgtgacac cttgactgta ttcttatgtg aaaacctgag ccacaggcac 45420
ccaactaagc tgtgacttag aaatattacc agttcaactt caaactcttc taaaaaaact 45480
gaaaataaag aagtaattcc caactcattc tatgagggca gtattaccct gatttcaaaa 45540
ttgaatagga aaaagaagaa ggagaaggag aagaaggaga aggagaagga agaggaggag 45600
gagaaggaga aggaggagga ggaggaggag gagaagaagg agaaggagaa gaagaagaag 45660
aagaggaaga ggaagaggag gaagaagaag aagaagaagg gaggaggaaa gctataggct 45720
aatatgtcct ataaacatag attcaaaatt ttaaacaaaa ttttaacaaa ttgagtatca 45780
ccaaatgtta aaaagagaat acatcattgt gacaacgtga ggtttatccc tggaatgtaa 45840
gctttgttta atatctaaag attgatcaat aactcatgac atttaccaac taaaaaagaa 45900
aactatatga tcatctcagt agatacagaa aaatttttga caaacttcaa catcaatttc 45960
tgataaagtc tcaacaaaca gcatagaaca gaacttcctc cccattgcgc agcacagctg 46020
ctgtggcaga ttgtggccag actgcttctt taagtgggac cccgatccat cccccctcac 46080
tgggcaggac ctccttgtga gaatttcagc aactccagcc agggttttat ggacagaact 46140
ctgatctctc tgggacagag cccctcaggg gaagggtggc cacagtctct gtggttcagc 46200
caacttagcc tttcctgcct gctggctctg gagagtctgg gcagtctgga caaaagggga 46260
tccccccagt gcagtgcacc cagtccccca aggggcagcc agactgcttc ttgaggcagg 46320
tccctgatcc cattcctcct gactgggtga gaactcccaa agggatcccc agacacctct 46380
tacaggagtg tttgggccag cgtcagtttg gagcaggcag ccatctttgc tgttttgcac 46440
cctttgctgg tgatagtgat acctccaggt gcagaaggga cccaggtgat tagggtctgg 46500
ggtggaccac tagcaaacca cagcagccct gcagaagagg agcctgactg ttaaaagaaa 46560
aacaaagcag caacaacaac ataaacaaaa aagatcccca aaaaaaccca ttgaaaggtc 46620
agcaacctca aagactgaag gtagataagc ccacaaagat aagaaagaat caatgcaaaa 46680
atgctgaaaa ctcaaaaagc cagagtgcct cttctccaaa tgattgtaat acctctccag 46740
caagggcaca gaactgggct gagactgaga tggctgaatt gacagaagta gccttcagaa 46800
tgagggtaat aacgaacttt gctgagctaa aggaacatgt tctaacccaa tgcaaagaag 46860
ctaagaatca tgataaaaca ttacaggagc tgataaccag aatagccagt ttagagagga 46920
acataaaaca cctaatggag ctgagaatca caacgtgaga acgtcacaat ccaatcacta 46980
gtgtctatag ctgagtagac caagcagcag aaagaatctc agagcttgaa aactgtcttt 47040
ctgaaataag acaggcagac aagaatagag aaaaaagaat gaaaacaaac aaaacctcca 47100
agaaatatgg gattacgtaa aaagaccaaa cctacaactg attggagtac ctgaaagaga 47160
tggggagaat ggaaccaaat tggaaaacat acttcataat gtcatccagg agaacctcgc 47220
caatctagca agacaggcca acattcaaat tcaggaaatg tggagaaccc cagtaagata 47280
ctccacaaga agatcaaccc caaaacacat aatcatcaga ttacccaagg tcaaaatgaa 47340
agaaaaaatg ttaagggcag ccagagagaa aggccaggtc atctacaaag ggaagcccat 47400
cagactaaca gtggacctct cagcagaaat cctagaagcc aaagaaactg gaggccaata 47460
ttcaacaatt tttttatttt ttgttttttt gagactgagt ctcgctctgt cacccaggct 47520
ggagtgcagt ggcgcgatct cagctcactg caagctccgc ctcccgggtt cacgccattc 47580
tcctgcctca gcctcccgaa tagctgggac tacaggcgcc cgccaccgcg cccagctaat 47640
tttttgtatt tttagtagag acggggtttc actgtgttag ctaggatggt ctcgatctcc 47700
tgacctcgtg atctgcccac ctcggcctcc caaagtgctg ggattacagg cgtgagccac 47760
tgcgcccggc ctcaacattc ttaaagaaaa gaatttccaa cccagaattt catatcaggc 47820
caaattaagc ttcataagtg aagaagaaat aagatccttt tcagacaagc aaatgctgag 47880
ggaattgtta caaccaggac tgccctgcaa gtgctcctgc aggaagcact aaatatggaa 47940
agaaaaaact taccagccac cacaaaaaca cactgaagta cacagaccag tgacactatg 48000
aaggaaccac ataagcaagt tggcaaaata aacagctagc gtcatgatga caggatcaaa 48060
ttcacacata acaacactaa ccttaaatgt aaatgggcta aatgccccca ttaaaagaca 48120
gagaatggca agctggccaa agagcaaaga cccgtcagca tcagcaaaca cccagatgct 48180
gtcttccaga gacccatctc aagtgcagag acacacatag gttcaaaata aaggaatgga 48240
ggaaaattta ccaagcaaac ggaaaacaga aaaaagcaag ggttgcagtc ctagtttctg 48300
acaaaacaga ctttaaacca acaaagataa aatagacaag ggcattccat aatggtaaaa 48360
ggctcaattc aacaagtagc gctaagtatc ctaaatacat atgcacctaa tatgggaaca 48420
accagactca taaagcaagt tcttagagcc ctacaaagag acttagactc ccacacaata 48480
atagtgaaag actttaacac tccactgaca atattagaca gatcattgag acagaaaatt 48540
aacaaagata ttcaggacct gaactaaact ctagattgaa tggacctgat agttatctac 48600
agaactctcc acccaaaaac aacagaatat acattctttt catagccaca tggcactcta 48660
aaattgatca tataatcaga agtaaaacac tcctcagcaa atgcaaaaga actgaaatca 48720
taacaaacag tctctccaac cacagcacaa tcaaattaga actcaagaat aagaaattca 48780
ctcaaaacca tacaactaca tggaaatgaa caacctgctc ctgaatgact cctgggtgaa 48840
taatgaaatt aaggcagaaa tcaagaagtt ccttgaaact agtgacaaca aagagacagt 48900
gtaccagaat ctctgggaca cagcgaaagc tgtgttgaga gaaatttata gcactaaatg 48960
cccacatcaa aaagctagaa agatctcaaa tcaacaacct aacatcacaa ctaaaaaaac 49020
tagacaacca agagcaaaca aatcccaaag ctagcagaag acaagaaata accaagattg 49080
gagtggaact gaaggagata gagacacaaa aaaaaatttc aaaaaaccaa caaatccagg 49140
agctgatttt ttttgaaaaa aaaaaagtta ataaaataga ctgttaccta aactaataaa 49200
gaagaaagag aagaatcaaa tagacacaat gacaaatgat aggggggata tcaccactga 49260
cctcacagat acaaacaacc atcagagaat gctataaaca cctctatgca cataaactag 49320
aaaatctaga aggaatgggt aaattcctgg gcacaaacac ttgcccaaga ctgaaccagg 49380
aagaaattga atccctgaat agaccaataa tgagttctga aattcaggca gtaacaaata 49440
gcctagcaac caaaaaaagc ccaggaacag acgaatttac agctaaattc taccagaggt 49500
acaaagagga gctggtacca tttcttctga cactatttca aacaattgaa aaggagggac 49560
tcctccctaa ctcattctat gagaccaaca tcatcctgat accaaaacct ggcagagaca 49620
caataaaaaa acaaaacctc ggacaaatat ccctgatgaa catcaataca aaaatcctca 49680
ataaaatact ggcaaaccaa atccagcagc acatcaaaaa gcttatccac cacgatcaag 49740
ttgacttcat ccctgagatt caaggttggt tcaacatatg caaatcaata aacgtaactc 49800
atcacataaa ccacatgatt atctcgatag acacagaaaa ggcctttgat aaagttcaac 49860
atctcttcaa taaactctca ataaactaag tattgaggaa tatacctaaa aataacaaga 49920
accatctatg acaaacccac agccagtatc atactaagta ggcaaaagct ggaagcattc 49980
cccctgaaaa ctggcacaag acaaggatgg cgtctctcac cacttttatt caacctagta 50040
ttggaagttc tggccagggc aatcaggcaa gagaaagaaa taaagtgtat ctaaatagga 50100
agagaagaag tcaaactgtc tttgtttgca gatgacatga tcctatgtct agaaaacccc 50160
atcgtctcag cccaaaacct tcttaagctg ataagcaact tcagcaaagt ctcaggatac 50220
aaaatcaatg tgcaaaaatt gctaacattc ctataaacca acaacaggca agcagagagc 50280
caaatcatga atgaactccc attcacagtt gctacaaaga ataaaatacc taggaataca 50340
gctaacaagg gaagtgcagg gcctcttcaa ggagaactgc aaaccactgc tcaaggaaat 50400
cagagaggac acaagcaaat ggaaaaacat ttcatgctca tggataggta gaatcaatat 50460
tgtgaaaatg gccatatggc ccaaagaaat ttatagattg aatgctattc ctattaaact 50520
accattgaca ttcttcacag aattagaaaa aactattata aaattcatat ggaaccaaaa 50580
aacagcccca atagccccaa tatctttttg cttaggattc taagcaaaaa gaataaagct 50640
ggaggcatca tgctacctga catcagactg tagtacaaga ctacggtaaa caaaacctca 50700
tggtactggt acaaaaacag atacatagac caatggaaca gaatagagaa ctcagaaata 50760
agaccacaca cctacaaaca tctgatattc aacaaatctg acaaaaatga gcaatgggga 50820
aaggactccc tatttaataa atggtgctgc aaaaactggc tagccatatg tagaaaattg 50880
aaagtggacc ccttccttac accgtataca aaaattaact caagatggat taaagactta 50940
aatgtaaaac ccaaaactgt aaaatcccta gacgaaaatc taggcaatac cattcaggac 51000
atagacattt catgacgaaa atgccaaaag caattgcaac aaaaccaaaa attggcaaat 51060
ggggtctaat taaagagctt ctgcacagca aaagaaactg tcatcagagt gaacagacaa 51120
cctgcagaat gggagaaaat ttttgcaatc tatccatctg acaaaggtat aatatccaga 51180
atctacaagg aacttcaaca aatttacaag aaaaaaataa ccccattaaa aagtgggcaa 51240
agggcatgaa cagtcacttc tcaaaagaag acatacatgc agccagcaaa catgaaaaaa 51300
agctcaacat cacagatcat aagagaaatg caaatcaaaa ccacaataag aggtgggtgg 51360
gtcacttgag gtcaggagtt caagactaga tctagaatca gaaataccat ttgacccagc 51420
agtcttatta cggggtatat acccaggaat ataaatcatt ctattataaa gatacatgca 51480
tgcataactt cactgcagga ctattcacaa taacagagac atggaatgaa cccaaatgcc 51540
catcaatgat agactggata aagaaaatgt ggtacatata taccgtggaa tactatgcag 51600
ccataaaaag gaataagatc atgtcctttg cagggacctg gatggagcaa actaatgcag 51660
gaacagaaaa ccaaacactg catgttctca cttataagtg ggagctgaac tatgagaaca 51720
catagacaca tatggggaga acaacacaca ctggggcctg ttggggaagg ttgggggagg 51780
gagagcataa ggaagaacaa ctaatggatg ctgggcttaa tacctaggtg atgggttgat 51840
ctgtgcagca aaccacctgg cacatgttta cctatgtaac aaacctgcac aggtaccctg 51900
gaacttaaaa gttaaaaaaa ttttaaaaag aagagaactt cctcaacctg ataatgtgca 51960
tctataaaaa aacctatacc taacatcatt tttaatggta aaagaccgaa tcctttccca 52020
ttaggatcag aaagaagaca agatatccac tctcacgact tctattcaac actggaggtt 52080
ttagccagtg caataaggta agaaaaataa acaaaagtca cctacttttt aaaaaaagta 52140
agaatgaaaa tatttttacc ctcagatgac ctgatcacct atgtagaaaa tccagtgaaa 52200
catttaaaag gaagaaacag ggcaggcatg gtagctcacc cacccaaagt gtaatcccac 52260
cactttggga agctgagaca gaaggatcac ttgaggtcag gagttcaaaa ccagcctggg 52320
cacagagtga gaccttgtct ctataaaaaa ttaaaaaatt agctgggcat ggtggtgcat 52380
agctttagac ccaaacactt agaaggctga ggtgggagga ttgcttgaat ccaggagctt 52440
gaggctacag tgagctaaga ttgtgccact gcactccaaa ctgggtgaca gagccagacc 52500
ctatctctaa acaaaacaaa actactagaa ctaatacatg agtttagcaa ggttgcagga 52560
tacaagatca atgtacaaca ctcaactgta tttccatata ctaacaacaa ataattgaaa 52620
aagtgaaatt aaaagcaata ccatttacaa cagcatcaaa tagatgaaat atttagggat 52680
aacctaacaa acaatgtgaa atgcctgtac actgaaaact ttaaaacatt gctaagagaa 52740
tttttaaaaa tctaaataaa tggagataca ttgtgttgct gggttggaag actcaatatt 52800
gtttaaatgt cagttcttcc ctagttgatt tatagactta atccaataac agtcacattt 52860
cctttttttg tataaattga caaactgatt ataaaattca tgtgaaaata tgaaggacct 52920
agaatagaca aaacaacttt taaaaagaat gaagttggaa gactaggacc acctgatttc 52980
aagacatatt acaaaactaa cagtaatgca gacagtttgg tactgggcaa ggatagacat 53040
attcatcaac agaacagaat agactacaga aataaatcca catgtatatg gtcaactgat 53100
tttcaacaaa ggtacaaagg caattcagtg gagaagggac agtcttttca gcaaatactg 53160
ctggaacaaa tgtatatcca tatgcaaaaa tgaactttga tctagctaca tgttacacca 53220
tattaagaaa ttaactcaaa atggatcaca gacctattta taaaacctaa acctgtaaag 53280
tttataaaag aaaacatata agaaaaattt tgtgaccttg gaataagcaa atatttctta 53340
ggtacaatac caaaagcatg gtccataaaa gaaaacactg atgaattaga ctttttaatc 53400
attaagaaca tcttctcttt caaagagaat cttaagagaa tgagaaaaag ccacagacta 53460
gaataaaata tttgaaatca tatatctggc tgggtgtggt ggctcacgcc tgtaatccca 53520
gcactttagg aggttgaggt gggtggatca cctgaggtca ggagttcaag accagcctgg 53580
ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa aaaatgagcc atgcgtggtg 53640
gaggcacctg taatcgtagc tactcaggag gctgaggcag gagaattgct tgaactcagg 53700
aagcagaggt tgcagtgagc caagattgct ccattgcact ccagcctggg tgacaacagt 53760
gaaactccat ctcaaaaaaa aaagaaaaaa aaaaactcta aaaacgcaat acagtggtgc 53820
tcccttatct gtggttttgc tttccatggt ttcagttacc tgtggtcaac catggcctga 53880
aaatattaaa tggaatattc cagaaataac caattcatag gttttaaatt gtacaccttt 53940
ctgaggagca tggtgaaatc tcatgctgtt ccactctggc ccacccagga cacaaatact 54000
ccttttgtcc aacatatcca tgccatatac actacctgcc tgttagtctc ttagtagcca 54060
tcttgattat cagattgcct gtcatggtat tgaagtgctt tgtgttcaag taacccttat 54120
tttgcggtgg ccccaaagtt caagagtaat gatgctgaca tattgttata atttggtatg 54180
gtttggctct gtgtccccac ccaaatctca tctcaaattg taatcctcac atgtcaaggg 54240
agggacctgg tggaaggtga ttgggtgatg ggggcagttt ccctcatgct gttctcatga 54300
tagtgaggga gttctcacaa gatctggttg tttgttaagt gtctggccct ttcccctgca 54360
cactctctct ctcctgccac cttgtgaaag tgtgtcttgc ttcccctttg cctttcgcca 54420
ttattgtaag tttcctgagg cctccccagc catgcagaac tgtgagtcaa ttaaacctgt 54480
ttttctttat aaattattca gtctcatgta gtacctttat agcagtgtga gaacagacta 54540
atacataatt gttttattat tagttatggt tgccaatccc ttactgtgcc taatttataa 54600
attaaacttt attataggta tatatgtata agaaaaatca gtatatatgg ggctcagtac 54660
tatccatggt ttcaggcatc cactgggggt cttggaatgt atcccccctc agataagggg 54720
gactattgta ataagaaaac aattcaatat tttaaaatgg gtaaaagatt tcaacagata 54780
cttcaccaaa gaagatatat ggatgacaaa taagcatatg aaaagatgtc caataccatt 54840
actcattaag gaaatgcaaa ttaaaactac attaaaatac cactacacac tcattagaat 54900
ggctaaaatt aaaaagactg agtaaatccc atgttggcac acactgctga ggagaacata 54960
atttggtcca accacttcac tttggaaggc agtctgggag attatttatt tatttattcc 55020
attcctggct gatttttttt atagaaatag agtttcacta tgttcctcag gttggtctca 55080
aactcctggg ctgaagcaat ctgcctgtct tggcctctca aagtgctagc attgcaggca 55140
tgagccaccg cgcccggcca tggcagtttc tttaaaagtt cagcatatac ctatgatgtg 55200
atctagctat gccactctta ggtttttacc caagagaaat gaaactgcat gtccatacaa 55260
agacttgtac gccaatgttc atagcaactt tctttgtaat agccaaaaac tggaaatagc 55320
acaaataccc attagcaagt gaatggctaa acaaattgta gtatatccat acaatagaat 55380
cctgctcagc aatttaaaac atgaattatt gatacttgga agaacaaaga tgaatctcaa 55440
aataattaca ctgaatgaaa gaagccaggc aaaatgacta catgctatgt aaatccaatt 55500
ccacaaagtt ctataaaact aaactaatct attgttaact aatctgtagt gacagaagca 55560
gatcagtcgt tgcctgtgga tgagtagggt tggcaaagag tcaggaaagg aggatgacaa 55620
aggggcatgt ggaagctttt tggggtgatg gatatgttta taccttgatt atggtatttc 55680
acaggtgcat acatatatca aaacttatca aatcatgtac tttaaatatg tatgtcatgc 55740
actttaaatt gtgtgccagt tataccttaa taaagctagt aaaactatta tacattctta 55800
tttttctgag caggttctca tggagaacaa aatacaccat acctagtgtt cgttttcttt 55860
tttttaatta attaattaat tgatttttat tagtgttcat ttcaaaggac cttgctaggt 55920
gtcctaaaac ctatctgatg actttgcctg atactgatga ttttattatg attttaaaaa 55980
atatttttag tagagacggg ttttcgccat gttgggcagg ctggtctcga actcctgacc 56040
tcaagtgatc ttcccacctc agcctcccaa agtgctggga ttacaggagt gagccaccat 56100
gctcagccaa tactaataat tgatatggga gaatgttttg tttttcctag attcctcatg 56160
cagcttaata aggaccataa taacttaact cttagaacaa aggagatatt tcaggcccaa 56220
agggaagcac atctggtgcc tcctctgaaa ttcacaaaat aagggcgttg ttgtaagttc 56280
tgcatgaagc taaacttgtt caaagtttat aagttcaaaa gtaaataaaa ggactatctt 56340
ttattctgag accttatttc aatatcactt gtgataatga ttatagatcg tagctgttat 56400
ttacatattg ctacttctca gggttaaagg tggcatttcc acagcagtat ctgggatttt 56460
attgcctatg aaatcaagaa ggtagagtaa caagaattgt gtagggtatg agcttttacc 56520
ttacatgcaa gttaacaagt tagcctggta atgtttgatg gatgttagct aaagacatga 56580
gactcttggg tcagagaaaa aacacttgat tactcatggc aaaagcagta atcagaactt 56640
aatattgagc ttttactggt ttccatgccc cacgtgccat gaggggaatg aaagtcccat 56700
aatggatgtt tatggatgtt tgcacacaca cagtgggcta ccatttaagg agaggaatcc 56760
tgagcctggt aagtccactg cttttatagt gagttgtaac aagcctgttc tttgtctagg 56820
ggaagatgtt acctgatccc tcaaggttgc tcattacaaa cacaaccctg agaaatggcc 56880
tggataaaga gcagtcagag ccttgcttct tggcatacct gacaagaatg cacagagctg 56940
ctcagggccc ctggtaggtt tgcctcccac actagggact gtgcatggag gcacctgcca 57000
cttctgcctg catcctgggc tagcgtgaca gtcagagaca cagacaccag tgaatggctg 57060
aaatatgttc ctgtggtctt ctcactccac tacaacttcc ttcccagtta gggtccccat 57120
gcaggccctt tgagctgcac ctggcagagt tgagttacat actttcatgt accctgctga 57180
gtttgtcttc tttgccttca gaaattccaa catactacat gagtcatggt tcttggtatt 57240
attgttatac ccttctcaga atctctctga ctccccagat ttcacatcgt tttccatttt 57300
tgtaaaaggc ctcaaggtct ccatgctatg gagaagagtt atactcatct tttctttatt 57360
cttgcattcc tgaaagcctt acattagcat ccaagtgagg tttctctatc aatatcaaca 57420
gtaaatattt agtgaactaa acacctacta tgctcagcat aatgtataaa atatgattta 57480
agggttcctg ggagcttcaa atgcatcacc tgggtgcaaa aacatgagga aaccaaaaag 57540
tacattctgg tggttttttt aatagcattt aaaaaataat gccttgctgc agggatagga 57600
gctgtgctgc tttcatatca attctgttct ctttgtggtt tgagaaactg gagctgaagg 57660
gaaggtgatt gggaataaaa gaaagcagta ctgatttttc tggctaaaag aaagtttgca 57720
cactgtcatg cactattaga atttctggga tcttctttat aatccccggt ttgatggtta 57780
ttggccaaga aggaagaagg ggagctagtc aggcctagaa taattaccag ccatacagca 57840
taatctgggg ctagtgttgc agggtcaagg actgaatgag gcagagtgac caggagcaga 57900
tcctgcaagg ccttgaccaa aaaggaagct aaggttcata gaaggaaaat attgtattga 57960
tcatcaattc tagaggattg ggcatagagc caaaaatagg aggtgtatca tgagatcaaa 58020
agccattggt ggccaagcgc gatggctcac acctataatc ccagcacttt gggaggccaa 58080
ggcgagcaga tcacttgagg ccaggagttc aagaccagcc tggccaacat ggcaaaaccc 58140
tgtctctacc aaaaatataa aaattagctg gccatggtgg cacatgcatg taatcccagt 58200
actcaggagg ctgaggcagg agaatcactt gaacctggga ggcggaggtt gcagtgagcc 58260
gagatcatgc cactgtactc caacctgagt gacagagtga gaccctgtct caaaaaaaaa 58320
aaaagccact ggtatgtagg aatggtgcag gaaaaaagtg caaagcagaa atgaggtgaa 58380
aatatataga actatgaaca ggaatgaggt ctttcttgag tactggctgc cagatggagt 58440
acgagtgggt cagcagaagt taatgaggta ggttaaaagt taatgcatag gaatagtttc 58500
tgcacagtct tctgatgctg tccatcctgc agtcaggcct atatcaatat cagccctaga 58560
tgaagtggtc acaccctcct ttgtgcacct actgttacaa atagtcatgg ctgtcattac 58620
tccatcacag ctgatggcac ttactaggtt gagagaagcg gggctctgtc tcccttacca 58680
tacagtgagc tccttgagtt tattcatctt tgtgtttcca ttgtgcctgg actgcgcact 58740
gtttcccgaa tgaacaaatt aactggccta gaatatatct atgatgataa aggtcagttc 58800
ttagattatt gttttcattc tttaactgtt taagataatg tcaactctat gtaaaaattg 58860
tgccctaggt aagcagttgc tttttattat tattctctct ctttcttgat ggttactccc 58920
tctaggagcc caaagcatga cgtccagagc cccagattcc cagccatcct ggttgtgacc 58980
cttcattctc aactttcatt tcaatcttag tatgccatga aaagccgtct gcttttgaag 59040
cactatcagc cacagagttc tgtactttta gaaggccttc tcatagtcag attctcacaa 59100
atatacctat tgtttcaata aatatttatt gaattggcca gcaatgtttc agatactgtt 59160
ctaggtgctg gggttacatc aaagaacaag gtaggcaaaa tcactaccct cgtggacttt 59220
gctttcctgg agggggaata ggcaggacat aaaataaatt gtaaactatt cgggatgtta 59280
gtgatcagag aagaaaagta aaacagggac agtgaatggg gactgtcaga gtggtagttg 59340
ctattcaaga tcatttgacc aaggaaggcc tcgctgagga agtaacattt gagaatagac 59400
ttgaaaggca taaaaaaaca agtcattagg taaaaaccat tccaggcaga aggaacaaat 59460
aatgcaaagg gccagggatg gaaacatctg tagtgttcag gggaaagcaa ggaggccagt 59520
gtgactggag cagagtagat taggcaaaga acaggagtag ataagatcag caaggtaatg 59580
ggtgccacat cacgtaaggt cacacaggac agtgtaatga ctttggcttt tactctgtta 59640
tggggagcca ttgcaggatt gggagctgtg aaatggcaca ccttgcttac atctaatagg 59700
aaatctgctg ctgcattgag aatagacctt taaattttaa aagagatatc tatggcatta 59760
ccttaaataa agtcatgctc cttggagtgc ctcaattcat gtacattaat gggtaaaagt 59820
ggaattcaag aaaccctgga aatgtatggg ggagtcctct ttgtttctcc tctgctcatg 59880
tctggtgggt gagcactaac gccatctctt cctaagcgag ggctccctag cagagcaccg 59940
tgcacatgga ttcttcctat gctctgcatt ctttgccaca gggatgccat aatttggcaa 60000
tatgcagtag agactgcctc aagaggcagt tcccttcttt atctaagcca agagaaattt 60060
ggttctgcaa gtaacaagta attactgctg atgacattcc ttgtacacac ttgaagagag 60120
cgtggaccgc aaaataaaaa ctggagcaaa aagggactat cagataatcc agattaaaga 60180
ttggaaagga ggaaaacaca ttatttacac atacaacact tgattttatg agtagagaac 60240
acaacttatg tgtatgtacg ttgtacactt gattatatgt gtagagaatt caaaagtgtt 60300
cagataaatt atttagactt aaaaagagac aaataatttt gggaaggtga tagtggcagt 60360
agtagcatag gttttagata ttcctgaatc tccacataaa aacagcaact agatagaaga 60420
cacaaaactc atgggcaaca aaataaaatc catttacaag aaaattagat gatgaggtat 60480
tcttatgatc ctcaaaatat aaccggttgg ggaaagacca cccacagcca caagagctgt 60540
gttatttgtg tctacgtagg agaaataaga gagaggcaat ggacatctga cagacctgag 60600
aacagagaac tcaaaatagc ccaaaggtat tcactggaaa gcatgggtgg ggcaatttga 60660
gatcagcagc tgaaacttaa taaggggtga gtgcaaggga tccacctctg gaaggtctaa 60720
aaggaatgca gcagtctagc tgctgtgaaa tttctagact gatctggtgg ggctcccttc 60780
caagatagga tctcatgaag aagagaaact gtggggagta ttgagctcaa aattgagcag 60840
aatgaagaca atacagatga agaaggaaga ggaatatcca aatgaaagca tatcagagtc 60900
aggaaatctc cttggaaagc aagccagagt attttttaac accatattaa tacaatatag 60960
caaaggaacc atgtgaagtt agaaaagcta tctgaaccaa atgtcttttt aaaatcacat 61020
aaaaactaaa ttcacaccca caaaaatcta cagcaggaaa atatcaaggc caaatccaac 61080
acaacattat taacctaaga aagagaataa ggggaatatc tgcagacaat gaaagcatgc 61140
caaaaagata tgattgaaaa tagattgaga ccctaatgta ctatttcagg tgcattcaaa 61200
gacattgaag aagtcatata agacatagaa aagcaacata aatcaaatta ggaagctcag 61260
aaatgagaca attcaagaaa aaattagaaa taaacatcta aaaatgaagg ctgatctaga 61320
aggaactcaa caacaaatga atacaacata attctttaac ataaataaaa ggtagaaagg 61380
aagaaaattt tttaaatgga atgaaaaaag atttttaaaa agttttgaaa gaaaacaaca 61440
aatattgaaa ataggcaaaa aagatcaatt tatcaataat aagagtccct gaaaaagaaa 61500
ataaaagcaa ggaaagaaaa caagtataaa acaaacaaaa ccctctaatt taagaaaact 61560
gaaaatttga aactacgtat ggaaagaaca cactgtgtac ttgagtatat cataatgact 61620
aagttcagca gagttgttgg atgaaaggtc tatgtgtaaa caccatttta tgtaacattt 61680
aaacaaattt tttagatcat ttaaaacagc ataaaaaata taaaatccta tttgtgacgg 61740
ctttctagtg tgtcaacttg actaggccaa actacatttc ctagaattct ctttcttgta 61800
tgttttctga ccacaaagga gattctttct agatttggaa agctaaggga agttccagcc 61860
atcttatagc acacacattg ttgcgaacct gctgatccac ctactggggt gaagcagagc 61920
tggacatgca attgctctac cttcccctgg accctccatt aacttgtcag gcccctgggc 61980
caggtgtgtg tgattagctc cacgacaaag ggccacagct tctgcaggat atactcatta 62040
cctagatcag aggcaacaat aactgacatg ggtttcagtc tcttcacagg ggtgtgagca 62100
tgctctaatc tcttgatttt ccctcctgac tgcctgcctt gtagacttca agctctagca 62160
tcagatgtgg agacaacagc cttacagaga ctgcttaaag agctcccaaa attgcataac 62220
tcaactgcct gtgacacatc catatatctc tttttgaatc ctggctaata cagtaggaaa 62280
agatatgcat tatctctata tagaaaatca taaaatattt tgagaggaat taaattctat 62340
attcattgat cagaagactt aatattgtaa aaatatcatt tctccccaga ttgatatata 62400
ggttcaatgc aatagaaatt ccaacaactt gcatatgtgt gtgtgaaact tgacaagcta 62460
aatctcaaat ttatacggaa attcaaaggg ctaaaaatag gctggaaaga aaaggacaag 62520
ctgggcgcgg tggctcacgc ctgtaatccc agcacttttg gaggccaagg cgggcagatc 62580
acatgaggtc gggagttcga gaccagcctg gccaacatgg cgaaacaccc tctctactaa 62640
aaatacaaaa atttgccggg catggtgggg ggcgcttgta atcctagcta cttaggaggc 62700
tgaggcagga gaatcacttg aacccaggag gcagaggttg cagtaagcca agatggcacc 62760
attgcactcc agcctggatg ataagagtga aactctgtct aaaaaaaaaa aaaaaaaata 62820
ggacaaagtg agaggatttc ttcttctgga tatcaatatt tactataaag ctagtaatta 62880
aaacctgcta aatatggtat tggagcaagg agagacaaat agatcaatag aacagaatag 62940
agagaatcca gaaagagtca aggatatata gatgcttttc aataaatggt gcagggtcag 63000
ttggctatcc acatggagaa aaaagtgcaa cctgaatcca cctcaacaaa attacttcca 63060
ggtgaactac tgaaatggaa aacaaaaaaa cttcaggaaa gtcatagaag agagtatctt 63120
tatgaactag ggacatgaaa atatgttaaa cagaacacaa caagtattat tcataaggga 63180
aaatattgtt aaattgctct acattcgttc aggagcagcc tgggcaacat ggcaaaatgc 63240
cgtctctgct aaaaatacaa aaatacagcc aggcatcgtg gtgcatgcct gtggtcccag 63300
ctactctaga ggctgaggtg ggaggatcac tggagcctgg gaggcagagg tcacagtgag 63360
ctgagatcac gccattgcac tccagcctgg gtgggtgaca gaggaagacc ctgtctaaat 63420
tgaaaaaaaa aaaaaagctc tacattagaa attgagaact tctgttcatt aaggacatca 63480
ctaaggaaaa aggcaagcca tagactggga caatgtattc acaatgcata tgtcatcaaa 63540
gaatctttat tcagaataaa aaagtgggaa tctatatgaa aacatagaaa atccactttt 63600
ttaaaaatgt gcagtcttat gtttatcaca gcactgttca cagtagtaaa gtcatagaat 63660
ccatctaagt gtccatcaac agatgattgg attaaaatgt ggtatatttt tgccatggaa 63720
tactatacac ctataaaaat aaatgaaatt atgtcttttg cagcaatgtg gatggaactg 63780
gaagccatta tgcttactga aatgactcag aaacagaaaa tcaaaaacca catgttctga 63840
ttgataagtg ggagctaaac agtgggtata cacggacata caaggggcat aatagacact 63900
ggagactcca aatggtggga ggatgggagt gggtgaggga tgaaatacca cctttcaagt 63960
acagttcagg tgattggtac acttaatgcc cagatttcac cactgtgtaa tatatccatg 64020
taacagaact gcatttgtat ccctaaatcc ataaaaataa aaaaatttaa tttcaaaaaa 64080
taaaaaatgt gcaaaagata tgaacaggta catcacaaaa gaacaaatcc agatagccaa 64140
taaacaaatg aaaaagggct caacttcatt agtcatcaga gaaatgcaaa ttaaagccac 64200
agtgtgataa tactacatac tcacttgaat gtctgcaatt aaaaaaaaga ctgacaaaac 64260
caagtgttga gaaggatgta gaacaactgg aattctcatg catagtgtgg aagtgtgcat 64320
tgatacaatc acttttgaaa actgtttagc agtatctact aaacttgaac atattcatac 64380
cctgtgtcct agcaattcca gcaaaattgc atacatatat tcaccaaaat aatgcactag 64440
aatattcata gcaacactat ttgtaatagg cccaaattgt aaactgtttg aatgtccatc 64500
aacagttata atatctattt ataatgtcca atatatcaca gtatactcca tgccacaata 64560
tagatggctc tcacaaaaat aataaatagt gttgagcaaa ggaagccaga aaaagagatt 64620
ataccctatg ttactctttt tacatgatgc acaaaaacag gcagagctaa tctaagatgt 64680
tagaagtcag attgggtggg tggagaaaag ggagaataga gcaagaggaa gacttctgaa 64740
gcactaataa tatgtttttt gacttgcatg ctggttgccc aggtgtgtca gtttttgaaa 64800
attcagtgaa ttatacattt atatatatgc atttttgttt atgcatattt ttcttcagca 64860
aaagtttaaa aaataatctt tgggcttcct gaaaagataa aaaggaaacg tttaaaggat 64920
acatgtcaat tttttagcag agacaaaatt tttaaatact attttctgaa aaaaaattct 64980
ccctcacagc tttatattta ttattaatat tgaaggatat aatgaatagt tttactgtaa 65040
atgcagaagt aaattttata agacttgttt atggcaccat taggaatagt ttttaaaaat 65100
cagaacttgt gtttatcaaa agacactatt aaatgacacc aaaagcacaa gtaacaaaag 65160
aaaaatgtgt ttaatatcat caaaattaaa aatttctggc caggcaccgt ggctcacgcc 65220
tgtaatccca gtactttggg aggccgaggc aggcagatca caaggtcagg agtttgagac 65280
cagcctgacc aacacggtga aaccccatct ctactaaaaa tacaacaaat tagccaggca 65340
ttgtggtgcg cacctgtaat cccagctact tgggaggctg aggcaagaga atcgctcgaa 65400
cccaggaggt ggaggttgta gtgagcgaga tcttgccact gcactccagc ctgggtgaca 65460
gagcaagact ccacctcaaa aaaaaaaaaa aaaaaaaatt ctgtgcttca gataacacca 65520
ttaagaaagt aaaaagaacc tacagaatga agaaaacgtt ttcaaattat ataatagacc 65580
tgataaggga ctcacatcta gatatataaa gaatgcttac aactcaataa tacaaagaca 65640
aataaaacaa tttttaagtg ggcaaagaat ctgaatagaa gtatctcaaa aaagatatat 65700
gaatggccag taggcacatc attaccccta agggaaatca aaatcacaat gagttaccac 65760
tttgcatccc ctaagatggc tataatataa aaattaacaa gtgtttgtga ggctgtggag 65820
agattagaac cctcattcac tcctcctagg gatgtaaaat agtgtctgag ctagggaaat 65880
agtttggcag tttcccaaaa tgttaaacat agggttacca tatgactcag tgattaagct 65940
cctaggtata tactcaagaa aatcaaaaca tatgtccatg taaaaacttg tacatgaata 66000
ttgatagcag cattgtttat aatatcccta aaaggaaaca acccaaacat gtatcaacta 66060
ttgaatggat aagtgaaatg tgttatatcc atacagtgaa atattattca gcaattaaag 66120
tgacacactg actcatgcta ggacatggat gaaacttgaa aacatgatgt taggtgaaag 66180
aagctagtcg caaaagatca catttgattc catttatatg aaatgaccaa aatagacaaa 66240
tctataggga cagaaaggag attcgtggtt atatgtggct ggggaaatgc aaattaaaac 66300
tactaggaga tacataccga tggtatgtat gcttatcttt aaattatctt taaatttttt 66360
aagataataa gataaagatg tgaaactatg aaactctcat ttactcactg ggagggtata 66420
aactggtaca accacattag aaaagaaatt ggcgtatctt ttaagattaa caacacatat 66480
accttgagag ccagcaaatc catttctaaa ttctactcag tagaactatg tgcatattta 66540
tatcaatagg tgtacaaaaa tattcatagc agcattattg taatcaccca aatgttcatc 66600
agaagtataa ggaataaata aattgtggta tattcctgca atgggatatt atatagcagc 66660
tacagttaca cccagcaaca tgtataaatc tcacaaacaa catcaaataa aaaagccaac 66720
cacaaagtag catccactat gattcccatt tatgaagttt aaaaacaggc ataactcaac 66780
tatagtatta aaagtcaata tagtagttca ccttaaggga gaagggaaag agtaaaaagt 66840
ataatatgag gtagaatttt gaggtattgt aatgttctct ttcttgggtt atagttttct 66900
atatgatgtt ttctttgtta caatttactg agctatacat ttttaatttg tacacttaaa 66960
aatacatttc ctggccaggc gtggtggctc gtgcctgtaa tcccagcact ttgggaggct 67020
gaggcaggca gatcaggaga ttgagaccat cctggctaac acagtgaaac cctgtctcta 67080
ctaaaaatac acaacaaaaa ttagccaggc gtggtggcgg gcacctgtag tcccagctac 67140
tcaggaggct gaggcaggag aatggcgtga acctaggagg cggagcttgc agtgagccga 67200
gattgcacca ctgcacttca gcctgggtga cagagcaaga ttctttcaaa aaaaaaatat 67260
atatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtatgtgt gtgtgtgtgt gtctgtgtgt 67320
gtgtgtgtgt attctggccc aagattatag ttttttttaa ggcagtctgt caggggtcta 67380
caattgtatg agttataaat aaggagtgac aatatcttca gtgaactcct gaacatgaaa 67440
accaagggtc gactgcgaat accttcttta catacaacca gacattatgg aatgaatgtg 67500
ttccccccaa attcatatgt tgaagctcta actcccagtg tgtctgtatt tggagatagg 67560
gtctttgggg aagtaattaa agttaaatta ggtcatacaa cctacagaat tggagaaaat 67620
atttgcaaac tgtgcatctg acaatggtct aatacccagc atctataaga aacttaaatt 67680
tacaagaaaa aactaacaac cctatgaaaa agtgggcaga gttaattttt tcatgagcaa 67740
tggaaaaaaa ttaaaaagtc tgaaagcagg caaagaacat gaacagacac ttttcaaaag 67800
aagacataca tgcagccaac aggcatatga aaaaaagctt agtatcactg atcattagag 67860
aaatgcaaat caaaaccaca atgagatacc atctcacacc aattggaatg gctactatta 67920
aaaagtcaaa aaataacatg ctggcaagat cgcagagaaa aatgaacaca tacactgttg 67980
gtaggagagt aaattagttc aacattgtgg aaagcagtgt ggcgactcct caaagagcta 68040
aaaacagaac taccattcac cagcaattcc atttgtggtt gtatacccaa aggagtataa 68100
atcattctac cataaagacg caggcacatg aatgttcatt gcagcactat tcacaatagt 68160
aaaggcatgg aatcaaccta aatgcccatc aatggcagat tggataaaga aaatgtggta 68220
catatacacc atggaatact atgcagccat aaaaaagaat gagatgatgt cttttgtttg 68280
aacatggata gagctagagg ccattatcct tagcaaacca acacaggaac agaaaaccaa 68340
atactgcatg ttctcactta taagtaggaa ctaaatgatg agaacacatg gacacaaaga 68400
gaggaaaaac acacactaca cactacctga gggtggaaga tgggaggagg gagataatta 68460
gaaaaaataa ctgttaagtc ctaggcttag aacctgggtg acaaagtatt ctgaacaaca 68520
aaccccccga cacgagttta cctgtataac aaacctgcac atgtacccat gaacttcaaa 68580
taaaagtctg tgtgtttttt aaggcagaag tcagccccta ccttgaaaga actttctaca 68640
tagatggcta cagtgttact gagcgttttt tttttggtct atcctgaatg tcatgggaaa 68700
acttttaaac tgctctggat caagattagt gcctgtggta tttcatttct cctactcaac 68760
tgttgcagtt acatgatctt agaaattctt tttggcatat tgatgactgt tatcattcaa 68820
gttacatcaa gagagacttc tttctatgag gagctattaa gaccctcttt tggacacata 68880
cacaacttca atttacatct aagacaactt attttaatga aattgcttat ttgtttgctt 68940
tagtccttag attatatgat catttgggca gggactattc tttgaatatt tcctggcaca 69000
tttttgtctc aataaagagg aaggtgaagg aagaaagaaa ggaaaggaag aagggaggga 69060
ggaaggcatt cttgttttct atatcctaaa cctataattt tgtcaaaaaa gaatattaaa 69120
tttgcctaaa atgttaacaa aaaataggtc ataatgatgg ggccctaatt caacagggct 69180
ggtgtcccta taagaggaag aggcattgaa gtttgctctc cctgcatgca caaagagact 69240
atgtgaggac acagcaaaag gacagctgtc tacaaaccag gaagaggcct cgccagaaat 69300
cagcccttga aaaaacctgg gtcttggact ttttgcctcc acaactgtga gaaaataaat 69360
ttctgttgtt taagccaccc agcctgtggt gttttgttat ggcagcccga gcagactgat 69420
acaccagaca ttcactgtat ccaactgttt caccataata gcctttctta ttttgatcaa 69480
attactgcat caggatttga tcttaaattt catgtttcct ttgcttttgt aaatgtagct 69540
gagcatccaa atttcactca gtttggatgc taacaagatt agacagttat ctgacagtaa 69600
tcagtgcctg atcctattct gtgtcttctt ccatcaccat cccactaaag agcttgcatt 69660
ttttgtttct tttagccaga tagtaaacat ttttcaggca ttttgaattt tgccattgta 69720
aatggtgaaa gattctctct ctctctctct ctctctctct ctctctctgt gtgtgtgtgt 69780
gtgtgtgtgt gtgtgtgtgt attaggaggg ggtggtgatc gggatgctaa tctatgcaca 69840
gtgacctttg tttctatctg gctgagcaga tgtaggaatt aatcattgtc actcctggat 69900
ggtgctgctg cagctgtccc ccactgcctt tctgcccctg atagatttat tagtgtgttt 69960
tgtttgctga aaagcatgcc tcagcacaga agaactggca aattagagaa gctttatctg 70020
tgagtataat tttttggaaa catggttttt tctacacatc tgtacctata tactctgagc 70080
tctttaaaaa aaaggaggag gaagagagca aagaaagaaa aggaaaacaa acaggtaata 70140
ttgtttctgt aacatcagaa cgattatttc ccagctgaga atgttcatac tggaacagtg 70200
tcatggccat ccaccttagg attgcagaga accaattgtt ttctaacctc tgtatttctt 70260
tttgcaactg cccaccccct cacccactta actgccaact atcagccaga attttggcat 70320
actttggctc taggcacaag aaaataagtg gtctgggtta cttagtgcta aatttatttt 70380
atagtaggcg tcactacaac cttgagactg taactaacac tttctaggct ccaagcaacc 70440
ccactacgta gatatccctg cagcctcatc aaattcaacc cgtggggata ttgataccgt 70500
cctggatgga aatcagagta gccacacccc tttcaatgtt gggaatctgc caaacaattc 70560
agtataaatt tcctgggcct gggctgtgta ttttcattcc accccacccc caaatcagtc 70620
agcatgccct ggggcagaga ctaaagagcc gccagtgcct attcagagtt ggcttattcc 70680
tttctgatgg cccatcccct ccccgaaatc caagaccttg gccttagata tcttggctag 70740
cctgggcctt tctggtacca cccttcactc tctaggagct ctgagaattt tctgcacttc 70800
ccgacgctgc ttgatagagt gactcacagc ttactctttc attgactctt tctgtatttc 70860
tcttcttcag aatttctctt ctgctgctgc ttttagacat ccttgcatgt tcagtcccta 70920
aatcaccact gcttgttatt actttcatgt tcccaacatc tggcatatgg gtcttaatcc 70980
catgggtcca cccagactca tgaatttaaa ctcttctggt ctaaactctt ccaccaccat 71040
ttgagcctca attctgtgaa cagttttgtc tctaaaagcc acatacctta gtgtaagaag 71100
gcagattaat cctctgaatg tcaacttaac agttaggcct atctcccaag aaagagaaat 71160
gaaaactcct aattagtaat gactcatttt gatcaaataa tcaatttttg gaccattttc 71220
ttaaaactat attttattgc ctgtaactat ttcctggagg ataataatca tccttaaatt 71280
actatgtgtt ttgtgaagtt ggtgctttac ttttcgtgtc ctaaatatgc atatctgaat 71340
ctttaaattg tagcttctct ttcaagtgtt ctaggatttc atttgccatg gttgggatct 71400
ctttgtgatt tgataggttt cgatcacatc ctcactagcc ttctttccaa gccacagaac 71460
ggtctgtctt cattcagtag agaccctgcc attctagttt tctcgctgga atttgttttc 71520
ccatatcctt cttgagcaaa ggtgactaaa gccaaatgtt tcattctggc actttgtgag 71580
acgtgggctt taagctctca aaagaagaga aaatctcata gttttatatg agatatacaa 71640
tgaacaatag taaaatagaa atgttattgg caagaggagt ttttctccaa tatccatgag 71700
taagaattcc ttggacacat aagataacaa gaggaatata cttactctgt tttccttttg 71760
agatattctt tacataccat gaagttttcc tttctaaagt ttgcaattta atagttttta 71820
gtatattcac aagcttgggt aaccaccatc actatctaat tccagaacat ttttatcacc 71880
tgcaaacaaa accttgtacc tgttagcagt ctctcctcat ttctctcttc ctcccacacc 71940
tggaaaccac tagtctactt tctatctcta tagatttgcc tattctggac atttcatata 72000
aatggaatta ttgaacatgg ggccctttgt gtctggcttt tctcatttag cataatctta 72060
gcataatatt tataaggttt ccctgtgttg tagcataaag cgttacttca ttccttttca 72120
tggctgaaca tcccattata tggatattcc acattttgtt tatccattca tcagttgatg 72180
ctatctgttg tttccacttt gaggctctta agaataatat gctgctgtga acatttgtgt 72240
acaagttttt tcatgaacat gtttttactt atctgggtat atacctagga gtggagttcc 72300
tgggttatat ggtgactgtt taacataagt gtagaactgt ttttcaaagt gactatacta 72360
tttcacaatc ccaccaacaa tgtatgaggg ttccagtttc cctacatcat cactaacact 72420
tgttttatta tctgcctttt taattctagc catcctagtg ggtatctcat tgtggttttg 72480
agtcgtattt cccttatgac caatgatgct gagtgtcttt ttatgtactt attatccatt 72540
tgcttatctt ccctggagaa ctgtctattc aaatcctttg acatttaaaa aaattagatt 72600
gtcttggggc cgggtgcggt ggctcatgcc tgtaatccca gcactttggg aggctaaggc 72660
aggcagatca cctgaggtca ggagtttgag accagcctgg ccacatgctg aaaccccatc 72720
tctactaaaa atacaaaaat tagctgggta ttggtggcac atgcctgtaa tcccagctac 72780
tctggaggct gaggcaggag aatcacttga acccaggaga cggaggtttc agtcagccga 72840
gattgtgcca ctgcactcca gcctgggcga cagagtgagg ctctgtctca gaaaaataat 72900
aaataaataa ataaataaat attgtcttgg aaatatactt aaattaattg gcctatagtc 72960
ccagctactc aggaggctga ggtgggagga ttgcctgagc ccaggagttt gatgtttcag 73020
tgagctatga ttatgtcact gctctccagc ctgggtgaca gagtgagccc ccatctctga 73080
aaaaaaaaag gaagaaagag gaagaggaag aagaggagga ggagaaggag aagaagaaat 73140
gctcttaagt caatagttct caaacttggt tcacattaaa gtttcctaaa atcctgatgc 73200
tcaggcttta ccctaggcca gttaaatgat aatatcttgg ggtaggaccc aggcaacagt 73260
tttagaaaca aatctccagt tgattctaat gtttgagagc cattgctata gactacatga 73320
ctaagctgat gataccaata taaaaatgtt aaagatttga taatttagaa attatgccag 73380
gtattaaaaa tgggagactt aactcaaatg tgaatcataa aatgcctaat caggtcaaaa 73440
gatagagttg agatttgtaa taaagattga taaactttcc tataatagga agtttcaaac 73500
cacctatagc tagagaaaat gtctggctgt ggttcttgcc tagtgagcag gaattggttt 73560
tatgaggtaa ccatgggaga gccaataaat gtgagtgatc atgacaatta aatctttaag 73620
cccagataat ttatgtcaat tattcaatgt tcattaagga aagtgaaaaa aaatgagtat 73680
tagctaggag aaatggaaag ggaggctttt gaaaggcata aaaagattgg aggctatttt 73740
aagagacttt attggaagca tagaaaaaga gtatctgaga atttttaaaa atccaatcac 73800
ataaaaatgt gacagtcaca gtggttattg tggagggaaa atgacatctc tcaaagaatg 73860
taaaaagctc cccaagggag agcagggagc ccacagagtg tattaggtta agtacaaaat 73920
aggaaaaaag actttaagaa acactttcga agagagtcca aaacacataa agggattatt 73980
taaaatctat taaaaggaag aagctagaat aacagtggga tcttttgctg agaataaggg 74040
ggcacaggga gtgctgaggc accaaaagac aatagacaaa ctaattatgt gcctctgaat 74100
gtattgagaa agataccaga gtgatagcac attcaaattg cctactacga atggatcagt 74160
agtagttaat tcaatggttt tctgtgtttt gcatatttca agtcaggtag gcagaataaa 74220
tactgattaa tcactggaaa ctcttggtgt ttatcttgag atttctgaag gcctccagaa 74280
gaaatttttc tcgtcttgcc tctccctaaa gccactgccc ttgtcctccc tctcctatta 74340
ccaccaaggc tcctaagtgt atagtctacc ctagtcacct cactttctca tctccaattc 74400
attcttcaac ccattcttct aactccattg aaaggtcatt aaatctgact cattgccaaa 74460
gtcattaaat caacagatcg ctttttagac taaattcttt ctagccttta gatatataac 74520
accattaact gtttcttctg ttcttccttt ctgaaacctc ttttcttaac atttattata 74580
tgtgaatgtc ctggttttac ctgtctactt cttgctagct accttcactg gctccagaat 74640
tacttacgta tttctctttt ttgttttttt tttttaaggc tagtcaagtg aagcagtggg 74700
aatggagaag gaacacagaa atctgtaact ggttgtgatc aattaattgt agacactact 74760
gacttcagac aagccttacc tatttaattt tggtaacact ctgggttcca gtctcgattc 74820
acttcttaca ctatatcctt caccttgttt taacctctcc tgtgacatat cctagtgctg 74880
cctctcttcc cattttctaa cttcatggtt gatatagtca tatagatgtt tcacagttta 74940
ttctgatcca gtaaccaaaa ccagattaat atcttaccag caaacttgct cttcctttgt 75000
gtaattcctg tcgtggttaa tagcactacc atccacccgt tctcattctg gattcctttg 75060
tctccctaca catccggcta gttaccaggt tttagatatt taacctctga aatgtctttc 75120
aaatctttct attgtccatc tccattgccc aaccatagtc ttcatttgtt tttcatctgg 75180
actattgcaa tagtccccta actcatcttg ccgacatttt cagctactga tctcttgcca 75240
gcattttttt ttccccaaac acaatctagt tttaaaatac agacttctac tgcctacata 75300
actccttagg taagtattta aggtcttttg tagtctggcc ctaacataaa atatccactt 75360
ttccccttga aattaagttg tgccctggtc gtacatgaga atggccattc cttgagcaca 75420
ccatgcacat tcctcaccat gtctttgttc atgctcttcc ttgtttcaca actcttctca 75480
tttatcacct gacaaactcc tatctatcct ttaagacaaa tttctgtctc tcaaaatgtg 75540
ggccctgggc cagagcagca gtatcacctg ggaacttgtt agaatacaac ttcttggggc 75600
cccactttag actctgttta atccaaaact ttgtgtgata aggaccagca atgtgaattt 75660
taacaagctc accacatgat tctgatgcat tctaaaattt aagaaccact gttctaggga 75720
acaatttttt tatcaatggc catagcactt tacacatacc tgtattactt actgcattat 75780
ttaataacca tgtttactta ttcacttatt tatctggtct gctaagttgt gagtccccag 75840
agtcaaatac aatggtgctg tgttctgaca cctgccatag tgtctagcac ataacaagtg 75900
cttgataaga attcagcata ctaaaatata cccccttccc tccaggattc agtctagcta 75960
gagtaaatag agagggcaag atcaaatggt gtccaaggca tctactctta aaggtcgata 76020
tacaccacac aaaccaaaag cttacacact gacaataaca aatgtcagca aagtaataac 76080
caacgggtac taggcttaat acctgggtga taaaataatc tgtacagcaa actccaatga 76140
tactaattta cctatgtaac aaatatacac ttgtacccct gagcttaaaa taaaagtttt 76200
taaaaaaata aataaagcaa atgtcagcaa ggatgcagag aagctgaatc tctcatacat 76260
tgctgatgta cctactctgg aagacacttt agaagtttct tataaaatta ttccctcact 76320
gtgcgattca gcagtttcac tcctgtgtat ttaccgtaga gaagtaacta tgtatgttca 76380
cacaaaaagc tgtatgcaaa tgttttttag cagctttgtt tgtaatagtc aaaaactgga 76440
aacattaaca atcaaaaaag aaatcaagaa aacaattcca tttgtaatcg catcaaaaaa 76500
tgaaaacttg ggaaaaaatt ttacctaaaa gatgaaagac ctatacactg aaaactataa 76560
aacactgatg aaataaatga ggaaggcaca aatcaatgga aagatatccc atattcatgg 76620
attgaaaaaa tttatattgt taaaatagcc atactaccaa agcaatctac aaatgcaatg 76680
caatcttacc aaaattctga tggtgttttt cacagaaata tgaaaaaaac taaaattctt 76740
atggaaccac aaaagacccc aaatagccaa aacaatcttc accaataaga acaaagctgg 76800
aggtatcacc ctagcctatt taatttcaaa atctactata aagctatagt aatcaaaaca 76860
gcatgatgct ggcataaaaa cagacaaacc aatggaacag aatagagagc ccaaaaataa 76920
atccatccac ttacagtcag ttgatttttg acaaaagtac caagaaaaca caaaagagaa 76980
aggacagcct cttcaataaa tggtgttggg acaactatgt atccacatgc aaaagaatga 77040
aattatgcct gttaccccag cactttggaa ggccaaggtg ggccgatcac ttgaggtcaa 77100
gagtggagac cagcctggcc aacatggtga aaccctgtct ctattaaaaa tacaaaaatt 77160
agccaggtat ggtggcatgc acctgtaatc ccagctactt gggaggctga ggcaggagaa 77220
tcatttggac ccaggaggca gaggttgcag tgagctgaga tcgcaccact gcactccagc 77280
ctgggcaaca gagagagacc ctgtcttaaa aaaaaaaaaa aaaaaagaaa ttggacattg 77340
gacccttata ccatatacaa aaaatccact caaaaatgaa ttaaaagctt aaatgtatga 77400
cctgatactg taaaaactat cagaataaaa cacaggagaa aagctcctgc cattggtccg 77460
ggcaatgatt ttttggttat ggccccaaaa gcacaggcaa caaaacaaaa catagacaaa 77520
tgggattaaa ctaaaaagtt tttgcacagc aatggaaaca ataaacagag tgaagagaca 77580
acctacagaa tgggagaaaa tatttgcaaa ccatacatct ggtaaggggt aaatattcaa 77640
agactataag gaactcaaat caatagcaag aaaacaaata atccaataaa aagtggacaa 77700
aggacctgaa tagacacttc tcaaaagaaa acatacaaat gtccagcagg tatatgaaaa 77760
aattctcaca tcactgatca tcaagaaatg caaattaaaa ccatgagtta ttagctcata 77820
cctgttagaa tggctcttat gaaaaagaga gatagcaaga gttggggagg atttggagaa 77880
aagggaaccc tatacactat ttgtgaggat gtaaattagt acaactatta tggaaaacgg 77940
tatggaggtt cctcaaaaaa ttaaaaatag aactatcata taatcaagca attctacttc 78000
tgggtgtgta tctaaaggaa atgaaatcag tgtatgaaag agatacctgc actcccatgt 78060
tcactgcaac attattccca atagccaaga tatggaacca acctaagtgt tcatttacta 78120
atgaatggat aaagaaaatg tgagatatat atgtacacat acacacacac gatggagtac 78180
tatttagtct taaagaagga aatcctggca tttgcaaaaa catggatgaa cctggaagac 78240
attatgctaa gtgaaataag caagacatag aaaaacaaat actacatgat ctcacttaca 78300
tgtggaatct aaaaaagttg aactcataga agcagagagt agaatggtag ttgccacaga 78360
ctagggtgga ggtggttgac agaaatggag agatgttggt cagatcaaag agcacaaagt 78420
tccaggtagg acagataagt tgtggagagc tatacagtat agtgtctata attagtaata 78480
acgtgttgta tacttgaaga attccaagag agtatgtctt aaatgttctc accataaaaa 78540
aagataagta tgtgcagtga tggatgttga ttaaattgat ttaataattt taattatttc 78600
acaatatata caaatatcaa aataccatgt tgtataccat aaatatataa tatttgtcaa 78660
ttctgcctta ataaagctgg gagaaaaaaa ctggaaaccc aaatatcctt caacaggtga 78720
atggataaac tgtgggacat ccatacaatg gaatactatc tagcaataaa catgggacaa 78780
agtattgata gatgcaacaa cttggatgga gctcaagggc atatgctgcg tgacagatgt 78840
cagtctcaca agcttacaca ctgtaagagt ccagttctat acaacattct taaaagacaa 78900
atttatagtg atggagaatg ggttagtggt tcctaggagt taggttgggg aagcgtgtca 78960
ctataaagga tagcatgaga gagttgtgtt tataagtgtg tatgtgtgat ggaacagttc 79020
actatcctga ttatgatggt ggtttcgtgt ggtgaatttc atagaaatct atatatgtga 79080
taaatttcat aggactacac acacacacac acaaagtgca cataaaaact ggtgaaattt 79140
aaatagagcc tgtagtttat ataatagtat tgcactaatg tcaatttcct gattttgatc 79200
atgaactctg gttatgtacg atgttattgg ggaaagctgg gcgaaggata cacaggaact 79260
ctctgtactg tttttgcaac ctcttgtgag tcttaaataa tttcaaaatg aaaagctttt 79320
gagaaaaata aagcacaggg atttctgaca aaagctaaat tagaaagcac tgcttgacat 79380
aatgctaaaa caggacccag gaagtggaga gctcactgcc tggtggaggt gggaaagggg 79440
taaagggaag tggagattct tgccttgaag aacatttggt agaacgtggg ccaggcctct 79500
caaacaggtc actcctggct tggggaggag ctaatactaa ggtggaaagg gaaatgaaag 79560
cttacttctc atcagcttcc catatgggga agggggccgg aatctctcct caataggcct 79620
ccattttctc aatagggaaa acggagagaa ggggaaaagg gttcctcttt aacaatggtc 79680
acaaaaggtg atgtgtgcag tgaaagatta aatggtataa gaactcaggc tctggaatca 79740
aacccagcct caaatccagt ggcttgattt tctattgaac tttgctatac cctgtttctc 79800
tatttaaaaa caggggtaat gatactactt aactctgaaa gctgattaca ttagattgtc 79860
tatgtagagc acttagcaac cacctagcac atagataatc agtgttggct actcttttta 79920
atactattct atgccattac caattttcta agacgtaaca ataatacact cagatgattc 79980
tgaccataat gtaatttttg attaaagttt cttcaggatc cttcaatgct tccaactcat 80040
aaattatatc agccctcagt ccctatatat gtaaatacaa tttaaattaa aatagttgtt 80100
actttctatt acatgtcttt tatgtgcttt gcactttaaa tacactattt ctaaccttta 80160
tagcatgcag gataaatact attttcccca ttttcagatg aggaaactgc ttcagagtgg 80220
ttaggcaaat ctccaacatc tataaacaac acagtaaacc taggcagtct gatggcaaag 80280
cccaagctct ttccactaca ctgttacctc agtagtaatc cataaaagat gcttaaacac 80340
atacatattg tctattagtt gttcttttta catcacatta catgggcaga ctctacaact 80400
cctgccacag cctggcgcag acacttccag gccattgctg aagccagtgg agacaccaga 80460
cgatgacaga aaccaagaac ccaaagctga ttgtagcaag aattcagtct ggagttcagt 80520
cagtagataa atccgagagg catcatggaa attgtgccaa ggtccaaggt tcaagccagc 80580
agtcagaatc taaaggggca ggcaaaaccc agcaggaggc tctgcaggct ctgtgccccc 80640
cgggagattc atggcttcct ctctgtctcc tcttgttgac actgccggct ataaatgggg 80700
gctttgtgga tcctcagttg aggaggcagg tgaaaattct tggcctacca gcactactac 80760
aggacgttag aaactagggc aggaagaccc tgggtcttca ttaatcagtg tgatgaaaac 80820
aggccccagg cagttgggtc cactagtggg aagtgaaaga acactgaagg aaaccaggag 80880
tcaggacatc tggatttgct gtcccaacat ggtccctatc tggcgataaa acagcatgca 80940
aatttcttca tctaaaaatg aaggaatcag gtcagatcac tgattttcaa actgtgttcc 81000
tcagaaccca aggactccag tcctgctgtg gagagatagg tgggagcaag caaggccttc 81060
ctgtacagca cgcttccttt catctcttcc aagtactgaa ccttctaatt ctaatgattt 81120
attcagcgta acaggcattt aataagtttc tactaggctc ggggccttgt agaaggtgct 81180
gatggggaca aagctgagta aaacccagtc ccaacatcat gaattcctag attctggctt 81240
aatggggaac cattccagca gctgtcactg ttcaggattc ctctcagatt ccaagataca 81300
ccaaggcccg gagttctgcc acagaattga agataagaaa gagaggaaag aggccgagtg 81360
cagtggctca tgcctgtaat ctcaccactt tcggaggccg aggcaggcgg atcacctggg 81420
gtcaggagtt tgagaccagc ctgaccaaca tggagaaacc ctatctctac taaaaataca 81480
aaataaattg ggcatagtgg tgcacacctg taatctcagc tactcgggag actgaggcag 81540
gagaatcgct tgaacctggg aggtggaggt tgcggcgagc cgagatcgcg ccaccgcact 81600
ccagcctggg caacaagagc gaaactccgt ctcaaaaaaa aaagaggaaa gaggaatctt 81660
ccccagtatg gcaggcaatc tttcctgcct caaggagatc aatttacatg tcacctggaa 81720
gcccataata ttctgcttta gcagtgactc cttgtgattg gatgtttcct atggccaatt 81780
gtgcctgtgc ttcatgccct acttaaaatc aggacatctg ctctgccctt ttggaagagc 81840
tacaagtctc ctgccaggaa ttgctcaagg ccttttcctg cagctaaacg gagaaaggaa 81900
gttgaaatca ttgcctcata aattacaaca catgccaggg ttgtaaccta gagtctgagg 81960
ttctaggcga aaagaggatt ttgtgtgtgt gtctagtgtt ttccccacag catttaaaag 82020
ctcatctaaa atatattata attgcatgag atatggcaaa aatacattca gaaactaatt 82080
ttttgaagat aaacaaacaa agcagaatgt gcccataata ttcctaagta aagccacaca 82140
aacttccttt ccagtaaggg tatcctttgg ggctttttcc ccctccttgt caccaactta 82200
tcttgaattt atcactatgc tttttcacta ttgttcctaa acttcagctg ttatataatg 82260
agatagtggg catttagtct tatatccaaa tttccatatt tcagctttta aaatagttgc 82320
aaggatgctt ttaaagttga tcctggccag gagaggtggc tcactcctgt aatcccaact 82380
ctttgggagg ccaagatggg aggattgctt gagtccagga gtttgagacc agcctgggta 82440
acaatgagac cttgtctctg caaaaaaata aaaattaact gggtgtgatg gcatgcactt 82500
gtagtgccag ctacttggga agctgaggtg ggaggattgc ttgagcccag tagataaatg 82560
ttgcagtaag ccaagatcat gccagtacac tccagcctag attagagagt gaaactctgt 82620
ctcagaaatt aaattaaatt aaattaaaaa gttgatccta gcaaactaac accggaacag 82680
aaaacccaac accgcatgtt ctcactcata agtgggagtt gaacaatgag aacacatggt 82740
cacagagagg ggaacatcgc acaccgaggc ctgttggggg ttgggggcaa ggggagggag 82800
agcattagga caaatactta atgcatgtgg ggcttaaaac ctagatgatg ggttgatagg 82860
tgcagcaaac caccatggca catgtataac tatgtaacaa acctgcacat tctgcctatg 82920
tatcccagaa cttaaagtaa aataaaaaaa gaaagaaaaa aaaagttgat ccttaggcct 82980
gtttatagtc caagggagct gtgaatgctg aaatttgtac actgtcaatt tatatgtata 83040
ttcacatatt aatatctata gtacacatag attcaggaat gtagactttt gtcaaatggc 83100
ctagtagata ctgataaaac aacttctaat attaaattaa aattttattc tattttaaag 83160
aaaaagaaca aataagaaaa tcgtctttgc aatgaaaagg tcagaaacca aggatgtggt 83220
gtcctaatat gctgatagca gagattatat ctcctttgcc ttcctatcac tggttcttaa 83280
taccttggca agttagtatt taggaattgt tgaattaatg tttggcacat gaagatcatt 83340
aaagcaataa ctcataaagc atggggaaaa caaggtcatt tgctaaaggg gaatttgggg 83400
gcacgatatt tagcaagtct tctttcacac ttatagctaa atattttgtt tatttgatta 83460
tttgattgat ttgggtgtaa attctattgc acctctggta aaccaagtca gcctgccctt 83520
cctggttaag aaagagagac agaaatgcaa agtgtaacca gcttattaat aagccgagga 83580
tagagaaaag aaatttgtct ctgggctggg agcagtggct catgcctgta atcctagcac 83640
tttgtgaggc cgaggcaggc gggtcacttg agcccaggag tttgagatca gcctgttcaa 83700
catggtgaaa ccccatctct actaaaatta caaatattag gcaaggatgg tggcatgtgc 83760
ctgtaatccc agctacttgg ggtggctgag acacgagaat cgcttgaacc cgggaggtgg 83820
aggttgcagt gagctgagat cgcctcactg cactccagcc tggctgcact ctagcctggg 83880
caacagagtg agactttgtc taaaaaaaaa caaaaaacaa ctgtctctgg cataacttga 83940
gaagggagaa gctagaagag acctttggtt tcatcaggtc caagcactgc taaccattca 84000
gctattctgt gggcagaatg tctttgttct tccaggtgca acttcagcag ctgtgggcct 84060
gaactgacag tgcggggtaa ggatatcact ctctccatgt gaaacaaagc aggactacag 84120
gaaagcaggc tgatttggaa aggccaggcc cacccaggac aagaggcagt gctgagtgtt 84180
tggctcatga caaaacataa tttacaaatt tactggcttc aaggatgtaa aaagttataa 84240
tttactggct tcaagggtgt aaaaaggcct gcttcctagc ctagctgcaa gcagcaactc 84300
agtccatgat cagcagattt tctgaagcct gggggtggga tgcatgttgt taacctctga 84360
tgcagatgtc tgctgagagt ctgtaatctg tgtggtcatg aagatgagat ttcatccatc 84420
aattgcttga caagggctat catcgtatct ctgggcctgc gtggctctca acacacgacg 84480
taagaaacat attggacaaa agcatttcct gggagaattc tccagcaaga attcagccat 84540
tggcaaagaa tctttcaagt ggccctatct cactggagac aagtaaacat atacgcagtg 84600
catatgtgaa tatacactcc ttcaaggtgc tgcactttcc tagaaacaaa aagaatgaga 84660
ggaaaaagct ttacaggcat cctgttagga tgctttctct cgtttatttt taggctcttt 84720
tcagctctgt gctaagaggg gaggcaaagg aagggcttac ccagaatgca aagcttttta 84780
gtgagggttt ggggtgtgca aatttgttaa agtggtgaaa acccagtgtc tatggaagtt 84840
cacagcatcc acagcactca gagcccccca aatatctctg gcccttgtgt tcactaattc 84900
caaggaattc tcagccattc caggggactg tggggatccc cctgaaacca ctacaattac 84960
ccagaatgtg cccctcctaa cacataggca ttgaaccagt tcctaactct cccccaactc 85020
tcacagatct ctagtacttt aagagccata tggcacacat gcttagccct cagccttctg 85080
cctaataggg gagtgctttg ccagggaaaa ataagattag ggaagaggac aaagaaagaa 85140
gaagagaagg agtttccata tccattaatg aattcattca acagatggtt atggaacact 85200
taccattttc caaagaccgt actatggtgt gggttataga ataagaaaca gcctggcttt 85260
tgaggagtag aaactgtccg gtggaactaa cattaaaagg tggtaatata acatgacaat 85320
tgtactgatg cacatagacc ctggggtgtt ttagggacat agaggatggc accaaaccta 85380
gactgagggc atcatccaga cagatacatg ctcttgtttc tgtgagtcct gtgaggtgag 85440
tcactcacaa agaaaatgta aagaaataac tcagaataaa taaaaagata gatggcacag 85500
taagcttggc agattgatgt tggagaacgt cagttttggt ggcaacaatc tgcaaggttg 85560
tctaattttc tcctgcacca ctcggctgcc cggatgcaaa agcagacaat ggattgtggc 85620
tctgatctga gttttattgg gcagatgctg cagaagggct tgtttgaaaa gggaatagga 85680
tgttattgag agaacagttc agatgaccaa ccagggatct gaaattaggt agagacagta 85740
agagagactg ataaactatg aggaagcaaa agaaccaagt gactggaggt ctataggctg 85800
tcaatgtaca aatgtggcag gagtaagcac atgagagggc tggaggatag gatgctcact 85860
catttattcc tcagatgttt attgagtgcc ttcagtgtcc aggtagtgtt ctagttctga 85920
gagtacatca tgcacaatgc tattgggagg agaaaacaat aaataaaatc ataataataa 85980
acaagtaaat tatgtaatat gttaaaaggt aataagtact atggttggat gggggcaggg 86040
gaagagaata gagcagaata agaattcaga attccgagga tagggtataa ttttaaatag 86100
ggttgtcatc atagctctgg ttgagaaggt aacatatgaa cacacaatca ggagagaaag 86160
aggatgagct atgcagatac atgtattgaa atattccagg cagagagaac agccacttca 86220
aagcctcgca gtgtgtgagt gcctggtgtt ttcaaggaaa agcaaggagg ctgtgtggct 86280
ggagtggagt gggcctggag aagatgtaag aaatgaggtc aagaaacaac agggatcgag 86340
tgtgtaggct ttgtagactc tggtaaagac tggctttccc tctgggaaat agagagtcat 86400
tgtggggttt tgagcacaga agtgatgtga tcttatgtct ctttaatgga ttactctagc 86460
tgctatgttg aaaatagact tgagggaagt gccagggtag aagcagggag accagttagg 86520
aggctattgc aataatccaa ataagaaatg caaagtaaga ctttgatcag gtggtggcag 86580
cagaggtggt gagaaggagt tagattctgg atgtatttcg aggatagagc caacaagatt 86640
tatgacagat tggatgtggg tagtgagcaa gagtcaggat gactccaagg tttttggtcc 86700
aggcaaattg aaaggtggag ttgccattat ctgaaatggg gaagaaggtg agcaattgag 86760
agggagactt ggagttaaat tttgaacaga ttgtagtcaa attggtgttg ggatattggt 86820
gtttacaatt cctgaagggg aaccattctg agtgacccta agacccagag tgtaacctgg 86880
ggatgggtgt ctgaagagga ataaagtgaa atcattatga ttgaataatt tagaactctg 86940
gaggctgaaa agctaatgaa atctcctagg atgttctacg aggatggtgg cccaggcacg 87000
agagtaggga acggggtcag gccttatgat ggatacttta aatacaaata gttagaggtc 87060
acactaatat tagcttgagg tgtgcagaat tttaattggg tgcagattag tgtatacatt 87120
agaaataagc aagatattaa aagatcaaat ttgctgaaac acatcagata acattatgat 87180
aaaggtattt ggagttttat ttgagttaga tttacaatcc cattgtagca tggatcaaaa 87240
acagtaagtt gataaagaaa tcagataaat tttcacaatt taaattttaa ttgttttatt 87300
aaaaagcatt ttggaaagac attcatattt ggttttggat aggttaaagc tcagtgatac 87360
catttacatc aatttttata gcattttaga gagcatggtc ttgtgacatc ttaggataag 87420
ttttctgtta gtcacagcat gccaacaagt accttgtgct ccattctctg gccatgtttt 87480
cagactcagt aacttcaaat aaaataaact gccaagttga gaaattaaca tttgataaag 87540
tttttgcaac atcataccat tgagctggtg gatgtggctt aagcatctga attcattaga 87600
gactattgaa atgataatgc agaattatac aggttttgca gatgtagttc aatatttatc 87660
tatatgtatt gaaacctcac ttgaggatag aaaaatcaag caagttcttg tcttacattt 87720
ccactcaata aatgaagagg aagagataat gagaaagcta tataatcctt taaaaaaaaa 87780
attcaccttg tttctgactg acagtaaccc aattcaggct ttttactctt cataaatgga 87840
agacaagtaa cctagatagt actggctatc tataattaaa tatacaatat tgaaatctat 87900
ttgctttgtg gaaattatgt gtttgtggct gattaaaata ttcagctatg taggcttcat 87960
cttttagctc aatagaaaaa tataaatgac attggtgact gaattcctac caacgtggca 88020
aagacattcc ccagacatac ataattcacc tgctgaattg gagatgattc acctttcagt 88080
gacttcacag gtgttaactt ggccaaacaa aaaagggaaa tcatcttgta ttcatctttt 88140
gttccctgag gcaagttttc agtaagattg ctcgggaaaa atatcacaat atacatatat 88200
aagtccatag tatgtctatt tgaataatga attagcacca ctgtctgaga ggtgaaaact 88260
attcaatgta tattttctgg aaaataacta aattgagttc ctcttaacta aatcagaaag 88320
agaaggaatc ctcaatcagg atttcatgta gtactgtatc actcaaagga aaactgattg 88380
tatagtggta ctcaaataaa gtgggtccaa agaaaaatta tgagagaaac gtaccgatca 88440
gtgatctgga ccaaacagac atgtggctgt gaaatccagg cagttgcttg gtgacgaggt 88500
caccatcaga tagtcatggc ttatgtgcag gaatgtgaga atggccatgg ggaggaatgg 88560
cctgggttat gggtcttgca ggagtcccac tgcttgtgcc attgctcaaa cttctgactg 88620
ccctgtgcag ccggtgccag gtcagcagta ctctctgctc tgaatcagtg tcagcactgg 88680
tctctctaat gtagtacctt tcttcaaaaa atgctttgtg aagctgctgg ttagcactgt 88740
tcttacttct gtagttaata ttcaccacat attccccttc ttttgtggag agataaagaa 88800
attaaggaaa atcactctcc ataagtccac aatctgaaga catggaggct gaggaggcag 88860
acctgaatga ataagtggat catatgatag ggctagatct taaatttgga tacaggagac 88920
ttaaggtaaa ccacagaagc ttgttgttta tacatgtagc tcttttgcta aatataaatg 88980
tggcatgtga agattaataa atctgaatgt aatgtacaga atgtactaga acaggaaaaa 89040
attggtgttt actgagagct gaaggttaca tcaaaaatct aaaaagtaat atttttgcat 89100
catcttaaag tttgcaaaca gttttggcac atacatcatc tcatctttgc aataacctgt 89160
ggggtagata caaaagatga tgttattttc attttccaga tgaggaaata ggagcctgtt 89220
tcctggtcag acaggcttag tcagctgtga gtggcagagc tggtgttccc acctgttacc 89280
ctcaacccca gttccattgc tcctaacatg attgtatcct ggataaacat ggtatcaaga 89340
atggagaggc caagcgcggt ggctcacacc ggttatccca acactgtggg aggccgaggt 89400
gggcggatca cctgaggtca ggagttcgag accagcctgg ccaacatggt gaaaccccat 89460
ctctactaaa aatgcaaaaa ttagatgggt gtggtggtgc gtgcctgtaa acccagctac 89520
tggggagact gaggcatgag aatcacttga acctaggagg tggaggttgc agtgagccga 89580
gattgcccca ctgcactcca tcctgcacaa tagaacaaga cactgtctca aaaaaaaaaa 89640
aaaaatggag agtgaaattt gggaggctga ggcaggcaga tcacttgagg tcaggagttt 89700
gagaccagcc tggccatcat ggcaaaagcc tctctctact aaaaatacaa aaatcagcct 89760
ggcgtggtgg tgggcacctg taatcccagc tgctcggggc tgaagcagaa gaattgcttg 89820
aacctaggag gcagaggttg cagtgagcca agatcatacc actacactcc aacctgagca 89880
acagagagag actctgtctc aaaaaaaaaa aaggatggag agtgagagaa aactcagaga 89940
ctttgaaata agaagtgaaa gaggccgggc acagtggctc acacctgtaa tcccagcacc 90000
ttgggagacc gaggcaggca gatcatttga ggtcaggagt gcgagaccag cctggccaac 90060
atggtgaaac ctgtctctac taaaaacaca aaaattagct gggcatggtg gcgggcacct 90120
gtaatcccag ctactcggga ggctgaggca ggagaatcac ttgaaccagg gaggcagagg 90180
ttgtggtgag ccaagatcat gccattgcac ttcagcctgg gtgacagagc aagactctgt 90240
ctcaaaaaaa ttaaaaaaag aagaagaaat gaaagaaact tggcaattga ttgggtgttt 90300
ctgataaaga aacagaagaa ggaaaaggtg attcctaggt ttctaaaacc tggaagaggt 90360
ggacagtgag attataatat aagcagctga tgttggcaac atgcctacta tgtgccaggc 90420
catgtgccaa gcattttgcc atattgcctt attaaatcct tacaactctt tgaaggtaga 90480
tcgcataatt attattctca ttttagaaaa gggtgtgcat gaaagttgct ctcactttta 90540
gaaaaagaaa aaaatcttcc ctccaaaaca aggctaagct caactggatt cactggccta 90600
tgctgacagt acctggggcc tgggacagtg gtttggtgtt cttgtgtgta tggatgtatt 90660
acaatgtcag acacaaagta actaagccgt gctcctggcg gttatgatgc ttgcaaatcc 90720
agcactgcca aactgtttag tgcctcctag gtgctttgcc tgtggttaga acaagcttca 90780
ctaagtggat agttttgcct tggccctgcc tttaaggcag tctgccatgt catcaagaga 90840
cataggtaag aatgctctcc tccttagtta tgatttaaaa ataaaagtat aacaaagtat 90900
aattatcaaa tgactattag tagaaatgtt gcatttatat acactattta gattacaatt 90960
cttaaataca atgtctttcc ttcttgttac ttgtaattaa ttagtatcag tcactgtcca 91020
gtgtgagcct ggcattgccc ttaggttaac cagttcacat cctgaacttc tgttggtgcc 91080
cagggtattt gtctgaaacc ctgattattt acatctccct ctaactttca aatttgtctc 91140
caatctcatc taaaactatt aatacttgag aaaaggcctt tccccaattt cctgcttcta 91200
atccctttat cctctttctt tcttggaaaa gtagaggaaa atggtttaca tatcaaataa 91260
agtaaatagt atatgaaaaa aaaaaaacct ctaagggctc caaactctgt ggatatctac 91320
ctgctggtta tttattcact aagctgcaca tagcaatccc ctagcaacca taaacttcat 91380
gcataaaatc ccaactcttc tccaatacca cctgtttgta ggtagtcatc cttcttttaa 91440
aagacttggg agttatacaa ggaataagtg ccagagttta gttctttgtg aaaataaatt 91500
taaagaaatt ataagttttc acagggctgt aaagatgttt cttcccagtg gtccttcact 91560
ccaaggctgc actggagatt atgctggtga ggaagctttg gtctcgtagg tctttggccc 91620
caaggcaaaa ggtcatggct gtaagtgtct ttcttcctga tcccctctag gattgtgaag 91680
atgtccagtc ccaatctgaa cattgtgacc ttactgggca gttgtctcac ttacagtagc 91740
gcttacctct ttgggattca ggatgtttta gtggggagct caatggaaac tctcattcag 91800
gtaggtgaag ttttaaaatt tggttttgac tataaagttt tgattatttt tttaaaccag 91860
ctgctcccgt gggtggtggt ttcctttatc cttggagtgg gcacttttcg agggaatccc 91920
agaacacttg gtgaggttca ctctgtacct cgtgcgctct gtgggaccca gaccctacag 91980
atcagagtgt gtggagaact gataaaggtt cctcttgtga ctcttctgtc cccttccacc 92040
catagacaag actgtccatg ctgtgcattg ggacctccct tgtgtttggc cccattctgg 92100
gaaagagctg gcgactctac aaggtgttta cccaaagggt cccggacaag agagtggtga 92160
gtaggcagca agtacacaat gcttgactgt agatggtagc ttcagcattg gttaacagct 92220
agagaagctc atgcacatta ctgagcctag cccctttcag gacatccaaa gttcctgttt 92280
ctcattccaa accctggaat catgcagcct cataaggcct caggtctgga aggctgtgga 92340
tcagtgctgt tgaagatagg gcttcaaacg tgggctctgg ttcctatgta ccccaggccc 92400
tgtggggaca tgtgagctgg ccaatacctg gcaccagtgt gaggcagaac aagataccca 92460
gagactgttg tttggcacag gtgcgagctg gaagtgaagg gaggaagagt gattacagag 92520
aaactatagc aagtaagtag ttatttcctt ccctggagtc cagttctttt ctatgtagaa 92580
ggcagttctc tgtactgaga aggatgtgcc caaagcagtg agcaaggaag agcagataga 92640
atcaactcta agttatgtag cagccagatc accgacatgt ccctggtatc agtcatcaac 92700
ttaaccacat ttccccattt tatcaggttg tctgatgaga ctgctcaaac ctcaattcct 92760
gaccattatc ctcattgggt ataggccctg cccagaccca atatatcatt cagttggtgt 92820
ttacttctct ggaatgatgg gaatttattt tagcaaatgt tattgaatca tggtgcatac 92880
ttaccaaaag ctcagctgtg agcaaccata cctatgaaga agattgccta aaaggacaaa 92940
aactgcattc atccctcaag aacaccaatt tcttttttaa acagctttac tgaagtataa 93000
ctgacatgca gtgaactgca catatttaaa gcatatgatt tgataaattg tgacatggat 93060
atacaaccaa gaaacatggt gcataatgaa catatccctc atcttcaaaa gcttccttgc 93120
aaccctttgt tatctccctc ccctgtccaa tccttatatc ccttgttcct atcctcagaa 93180
aatcattgat ttgctgtcac tgtagatgag tttgcatttt ccagagtttt acataaatgg 93240
aaccatgcag tatggactct gttttctctg gcttatttta ctcacataat tgtttttatg 93300
aatattatag ttatttatct atgttgtgtg catcaatagt tatttctttg ttattgctga 93360
gtagtattac aatgcataga cacaatttgc ttatctgtag atggatgttt gggttatcgc 93420
cagttgtggc gattaaaatt aaagctgcta tgaacattcg tgtacaaagt ctttgtttag 93480
acataggctt ttatttctct tgggtgaaaa cctaagagta tggttggatc atatggtaag 93540
tgtatattta actttttaag taacagtcag actgtttttc gaagtggttg taccattctg 93600
catttccacc agcaatgtat gagagtccat ttcctccaca ttcttggcaa catttgattt 93660
gatcagtctt tttcatttta ggcattctaa taggtatgtg tggtagtatc tcattatgct 93720
ttcaaatttg catttctcta atgcagtatt gagcatttct tcacttgctt atttgccatc 93780
catacacctt ctttggcaaa ctttctgttc aaatcttcca cccatttttt ttttttttct 93840
gagacagagt ttcattcttt cgcccaggcc ggagtgcagt ggtgtgatct tggctcactg 93900
caacctctgc cttctgcttt ccagcaattc tcctgcctca gcctcccaag tagctgggat 93960
tacaggcacc caccagcaca cccggctaat ttttgtattt ttagtagaga tggggtttca 94020
tcatgttgac caggctggtc tcgaactcct gacctcgtga tccgcctacc ttggcctccc 94080
aaagtgctgg gattataggc atgagccacc acacccagcc tcactcattt ttaaattgga 94140
ttttttgttg tcttattatt gagttttgtg agttcttttt atattctgga tacaaaccct 94200
ttatcagatg tatgatttgc aaagattttc ttccagtttg ttcttttgtt ccttttactt 94260
tcatttactt cagaatgtct ttcaaagata agacatttct cattctgatg aagttgaatt 94320
taccaatgtg ttctttgttt ttaggtttct tgtttatttg tttgtttgtt tttgtatttt 94380
tagtagagac ggggctttac catgttggcc aggctggtct caaactcctg gcctcaagtg 94440
attcaccagc ctcagcctcc caaagttcca ggattacagg catgagccac cacacccggc 94500
cccaatgtgt tcttttatgg atcatgtttt tggtattata tttaagaaat ttttgcctaa 94560
cttaaggccc caaaaggttt tctcatgtgt ttacttccag aaattttaga gttttagctt 94620
tgacatttag gcctatgatc ggtatatggt atgatgtatt gattgaattt tagtttttta 94680
catatagaca tttgattatt ccaacatcat ttgttgaaaa gattgtcctt tcttcactga 94740
attacctttg tgcctttgtt aaatcagttg tccataagtg tgtagatcta tttctggacc 94800
ctccattctg tctcactgat gtgtctatct caacagcaat gccatattac cctgattact 94860
gtagctttat actaaatctt gaaatcaggt agtattagtt ctttgacttt cttcttctct 94920
ttcaatgctg ttttggctaa tctgggtcct ttgaatgccc atgtgaattt ttgaatcagt 94980
tcactgattt ctacaaaaat tcttttggga ttatgttgaa tctaatagat caaattatgg 95040
agaattggct tcttactaat gttgtgtcct ttgacccatg aacccattta tttaggtctt 95100
taatttttcc catcattttt ttgtactttt caatattgct ctttcacatc tttcatcaaa 95160
cttatttcta gggattttat atttttatgc tattttatat gttactattt ttttaaattt 95220
cactttccag ttgtttgttg ctaataaata gaaatataat tattattatt attttttttt 95280
gagatggagt ctcactctgt cgcttaggct ggagtgcagt ggtgcgatct cggcttaccg 95340
caacctccgc ctcccgggtt caagcaattc tcctacctca gcctcccaag tagctaggat 95400
tacaggtgcc tgctaccaca cctggttagt ttttgtattt ttagtagaga tgaggtttta 95460
ccgttttggc caggttggtc tcaaactccc aacctcagat gatctgcctt ccttggcctc 95520
ccgaagttct gggattacag gcattagcca ccatgcctgg ccacagaaat ataattaatt 95580
tttatatgct tagcttgtat actgcaacct tgctaaacta catgttagtt ctagcagctt 95640
ttttatagag tctatcagat tttctacaaa gatgatcata tcagcagtga ataaagataa 95700
tttatttcca atctcttgtc tgattgcact ggctagatac aatagtacaa tctgaataga 95760
agtggtgaga gcagatatat ttgttattct tgatcctatg gggaaaacag tcaaaactaa 95820
gaatgatatt agcagtagtt ttattgtaaa ttccatttat ccagttgggg cagtactatt 95880
ctattcttat tttgctgaga gttttaatca agaactgatg ttgggttttg tcaaaagctt 95940
tttctgggtc tattgagatg atcatacagt ttttcttttc ttagtttatt cgcatggtgg 96000
attatgttaa atggtttttt ttttaaaccc ttacacaata gactttattt tttagagtag 96060
ttttaagtta acataaaaat tgagcagaag gtacagaggt tttacatata cagtctttcc 96120
ccacacatgc atagcctctc ccattatcaa tattccccat cagagtatat acttattaca 96180
attgatggaa ctacattaat acgtcattat cacccagagt ctgtacttga cattagggtt 96240
cacttttggt gttgtacatt ttatgggtct ggacaaatgt gcaatgacat gtatctacca 96300
ttacagtatc atacagagta gttttactgc cctaaaaatc ctctatgctt ctgctcatta 96360
tctctttctc tccccatatg ttaaatgatt tagggtgtca aaccaacctt ccatccctgg 96420
gattagcttc atttggtcat gctacattat cctcttcata tattgttgga ctcagtttta 96480
taaaaacttt gtttagaatt tgtacattca tgtttttaat acatattgct ctgtggttgc 96540
cttgtaatat atttttctag ttttggtatc agggtaatgt tggctttata aaatgagttg 96600
ggaactattc ccttcttttc aatttcagga ataatttcta tagaatagca taattggcac 96660
tcatgtataa gtaccttaca atagtatgct tccttttatc cccattccta tctttgctgt 96720
tacatgttat aggccccatg caattctttt gtttaataaa tcaattatct ttaaaaatat 96780
tttatttttt tatttttaag acccaggaca acatgctgaa ttttgttatt ttctttaatg 96840
atatttaaat aatgaaaact aatcatgtat ttttctgttt agttaccatt tccagtgttc 96900
ttaatttcct gtatagatcc acatttttat ctcatattat tttcctttgc ctgaaggata 96960
tctaacattc cagtgtgggt gtgctactac tgaattcttt cagcttttga ttatctgaaa 97020
aagtctttat tttgccttca tttctgaaag atatattact gagtatagaa ttctagactg 97080
aaattttctt ttcttcttct agtactttca agatgttcct gcactgtctt ctcacttggc 97140
cttgtatctg atgagaagtg tcaggtttat tttatgtcta cacaaaatgt gtctttcttc 97200
actgcttgct ttgagtagtt tccctttatc actggttttg aacagtttga ttaggcaatt 97260
ggtttgtttt taattttaca aacaccttga atcacgtaac tggttgtgct tcttttcact 97320
ggttgtcaaa agctcagatc cacatttctt ctgctccaat tagtaaatgc tattatatat 97380
acactcttca tctgagcctt catcataatt ccctttattt tctctcttcc cggttgttaa 97440
atattttaat cctatcacag tatatatttt tctcaatttt atttttgtag tcacaaacta 97500
acacattctc ttcatcctaa gtcaaatacg gatggtccct gacataaaac agttcaactt 97560
acagtttttc tattttacaa tggtgtgaaa gcaatccaca ttcagtagaa accatactta 97620
aaatacccat acaaccactc tgtttttcac tttcagcaca gtagtcaata cattttatga 97680
gatattcaac acttcattat aaattaaatt aagctttgtt ttagatgatt ttgcccaggt 97740
gtaggctaat ataagtgttc tgagcacatt aaaggtaggc taggttaagc tgcaatgttt 97800
ggtagcctag gtgtattaaa tgcatttttg acttatgata ttttcaactt atgatgggtt 97860
tatccggaca taaccccatc ataagtcaag atcataagtc aatctgtaat tcatatgtat 97920
ataatgaaaa tgctaatgat tcttcctgca tctctgagtc ccaccctctc agttaatagt 97980
tattaacatt gtggtgtgac attcatatct atgtgcttat ataaacatat agaaataata 98040
gtttatttat tttataaaac accttgagtc ctttgtggga aaaggtagga tatgaagaag 98100
ttaaacaaat ggaaatgtgt aatgctaata atgatatcag catagaagtc attgtaaatg 98160
tttggtgtct gtttcatttt tgatagctac atttgaagct ccttgggagg gctgaccttg 98220
gagcatatag ctgagagcac atgggatact ctagcccctc tgtcatttag ccagtcaaca 98280
aggagaagtt ttgaccttga ctcttttgca gattatcaaa gacctgcagt tgctggggtt 98340
ggtggcagcc ctgttgatgg ctgatgtgat cctgctcatg acgtgggtgc tgactgatcc 98400
catccagtgc ctccagattc tcagtgtcag tatgacggtg aggggccaaa tccctagaga 98460
atctcatccc caaactggac tgacctctgt ggatacacag gagtcatcct tgcaacaaga 98520
agataaagga ctccaagagg agggagagtc aggagttgtg gcttccatgt aattcttgcc 98580
ctagtctgct gccactccca ctgctcctcc tgcccgagtg tctctttgtg ggcatacaat 98640
gagatatcag catgctggaa tctgcctggc agttctgcca cttccacatt atcaataatt 98700
aaaactttca gctatcggca gttaccttcc cctaattgta gaggtggagg tagtagttta 98760
aggtggcctt tggagtcagt caaccctggt tcaaatccca gctctaccaa gctcaccagt 98820
tgtgtgacct tgggaaagtt atgtaacctc tctaagtctg tttcctaatt ggtaaaattg 98880
agataataat actacctatc tcatagggtt gtggcaaaga ttaaatgaaa caatgtaggt 98940
aaaagactta accatgtcca gtacatacta ttcaattaac aagaagtatg gccgggcacg 99000
gtggctcacg cctgtaatcc cagcattttg ggaggctgag gcaggtagct cacttgaggt 99060
gaggagtttg agaccagcct ggccaacatg atgaaaccat gtctctacca aaaatacaaa 99120
aattagccag gcgtggtggc acatgcctgt aatcccagct acttgggaag ctgaggcagg 99180
agaatctctt gaacccagga agcagaggtt gcagtgagct gagattgcac cactgcactc 99240
cagcctgggt gacagagtga gaccctgcca aaaaaaaaaa aaaattatta tatatctcca 99300
gcctcacgag gggctgagga atacagtgga atcatggaat cgtgacactg caagattaat 99360
gtttaaggat tcaatgattt gcaaaaagca ggtgcataat gaaatagttt atagttttgt 99420
tgaggcacta atttgattgg ggtagcaaag cacataaatg aggggtaagc cctagtgtca 99480
ccaagcacac agctgttagc ccaactttat catctcttct cctaacacgt agtcactctc 99540
atttaggttc tagtggagtc acctaaatgc tgcagttttt acatactgag ggggtatcat 99600
gtactctaga agaattcatg ctccagcatg ttcacaaaga tctgctttgt gttcctggta 99660
attgtgggca cctccagttc tgactctgtg tcccttctag gtgacaggga aagacgtgtc 99720
ctgcacttcg accagcaccc acttctgtgc ttcccggtat tccgatgttt ggattgctct 99780
catttgggga tgcaaggttg gtaaccacat ctgatatggt ctctgtcacc aagaaaatgg 99840
atatgaagag ggaattacag gaattaacga ggtgatgtct gcaaagaatc ttgaactcag 99900
aggagacctc tgttgatgca taaacttcaa agccatgact gtttttactt ttctatttgt 99960
atttgtttgg gggagaccct ccaactcttt agactccctc attcagtcct cccccaaatc 100020
atctggaatt cacccactgt ttctcctatt tattggtctg gtttcttaat tgatttgaca 100080
ataccagttt tcccttcatc ttccctgcaa gaggaattat gaggagaaat ttgacccagc 100140
tttatttgtt ctcctaagtg cccttattat gtctcttgtg ttttcttcaa gatttgggcg 100200
aaggtgtcct ggtgcctttc acccacctga ctttctccct ctggttggaa gcaagactgg 100260
ctctgagaca gatggcagca ttcacagggc cctttgaggg gttccacctg tctcacagtg 100320
tctcccatac tgccccaaat ctctcaccat tagactcatt tgtctctgtt agatgggcaa 100380
aagtagaata ttatttccag aaggtagagg atacctgcat ggagcactga ggatggtcct 100440
cagaacagga cagctggttt tcagcttagg gagacagaga actggtgctg aggggtacag 100500
ggcagtcctg attccataaa caagcaagtc ctgcctgaca gcagactacc tgttgactat 100560
cagggcagag agttctggtt gactgattac tggcagagga aaaggaggag tttttgtaga 100620
aataagtacc ctttaagggt aaactctggc cgggcacagt ggctcacacc tgtaatccca 100680
gcactttggg aggctgaggt gggtggatca cttaaggtca ggagttcgag accagcctgg 100740
ccaaacatgg tgaaactctg cctctactaa aaatatagaa attagctggg tgtggtggta 100800
tgcacctata atcccagcta cttgggaggc ttgaggcagg agaatcactt gaacctggga 100860
ggcagaggtt acagtgagcc aagattgcgc cactgcactc catcctgggc aacagagcga 100920
gactctatct caataaaaaa aaaaaggggg ggtaaacttt acccacttca ccactaagaa 100980
agtattagaa gttgttgctt gtgaggaaca ggtttagggg taggccagac tagggcaggg 101040
aaacattcct ttttaactat gtgcaaatat tactttgaca gaaatatttt ttaaaagaag 101100
actctaggaa gtgaacagct cttgatctcc agaatcttgc taatggttaa aaaaggagct 101160
ttagttgtga cagatcaggg tttgaatctg actccgcccc tggctagcca accctgagcc 101220
tcatttaacc tctctgagcc tcagtttcca aattttaaaa tgcggatgat gataatatcc 101280
cctcagaact gttctgtctc taaagagtta atgcatgtta agagttttca gccgctcctg 101340
gtccatagca agagctcaat aaatgttaga tattattatt actattcttc cactgccccc 101400
tagacacttc tggaaaatac attgcctctg ttggttcctt gagtccctgt agaagagtgt 101460
gtcctcccta gcccagaaag ccagcacttc ccccatagct acttactttg tgactcaatt 101520
tgatttattt tctccattgc cttttatata ctctcatttc cattctattt tactgtaata 101580
tctttctgta ggaaaaagaa ggaaaaggat ggagcatcag gaaacttact gagccagacc 101640
ccatagactc cctggtcagt gagaagctcc tcaggaggac cccaatctcc acattgagtc 101700
ctaggacccc tgctctctgt caactgcccc ctaccccaca cttctcagca gttaaggcca 101760
gtgatatgca aggatcaaat atgactcact cagacaccag ccaggaatgt atagacactt 101820
gattcacacc catttcccct ttaacaagaa ttttaatgga attaaaaact tttagtggaa 101880
tcatatctga acatttcaaa atcacagaat taatttcatt tgccttttat taaattagca 101940
atgatccaac tctgctgaat accacctgat ggcgtcagtt acccaaaagt tgggcttccc 102000
tggtctcctg acttatgtgt cctctagtca ttgaagatct cagggtggcc acatttggcc 102060
ttcaggcccc atttgggaca ctgggcatta ggggaacctg gaaggtatct cttccatgct 102120
gactccttcc cttctggcac agccagttct ccaaaatatg ttctttagtg tcacccatga 102180
aggtggagtt gaccacgtca tatgatttga gggtcaccag caggtgtcct gctgatacct 102240
gactttattt tcattattag ttctccctct gaatcccaca gtcccacccc cacctcgtct 102300
cccatggcat cttcacgttc tgagtcatca acatgaacat ttttaggctg ggcgcagtgg 102360
ctcatgccgg taatcccagc actttgggag gctaaggcgg ttggatcacc tgaggtcagg 102420
agtttgagac cagcctgacc aacatggtga aaccccatct ctactaaaaa tacaaaatta 102480
gctcagcatg gtggcacaag cctgtaatcc cagctactcg ggggctgaga caggagaatc 102540
gcttgaaccc gggagacgga ggttgcagtg agcagagatc atgccattgc acttcagcct 102600
gggcaacaag agcgaaactc catctcaaaa aaaaaaaaaa agaagatttt tgtgcttacc 102660
ttaaatctac ctaccagacc aagtgttaaa agccaggacc atgacttctt tgtgtcacta 102720
ttttctgccc tacacgtact atggcactgc acacatagtc agaaaggtga acctaattga 102780
atctatgtgt tatgtattat tgactaaagc tttgatttct gtatgaatgc agctcctgtg 102840
gagggggcag cactttaagg tgctatgagt tattttctcc ttagtacaaa tgacaactct 102900
gagagcaggt ttatattcat aggaaagaga acagaatagg gccctgggtt ccttgtaggg 102960
gagcaagaaa tgtcacaaaa agggtgagaa ctatagatgg agctttcgct gtctgtgcct 103020
gccccacagt cttgcctggg tcccagcctg cctttgttct cccctttttt tacccttcat 103080
ctcccataaa cactcactgg catggagccg ctgctagcct gtagagatcc tttgtgtaaa 103140
ttttttgaag gcccatccct tctagtcaga tgcagtcttg caggtgcaag gcttggcaag 103200
cagatggtgc ctttgggcaa attagagaaa agagcccctt cctatgggca ctaccctggc 103260
tgtggcacat gacttgacaa gcagatcaga ggtcactttc agcttccctg tgcaccctca 103320
gctttgagca gggcaacacc agacaatggc tgtggtagca ctcactatca gaggttctgt 103380
gggcccactg tcctccaagt gcccaacagc tctttctgta gggatactaa cccacccaca 103440
tgatcctgtc ctatgccttg tctcagaaga gtcttattta atggctgact tgctgacttc 103500
tgataaacta attctcagca aaggagagga aaataacatt tattaagtat ctagtaggta 103560
taaggggctg ccctgagggt tttcttatgt gatatcttag taaatcctca tagcagtcct 103620
taaggtaggt attattatcc taattttaca gatgaggaaa ttggttgcaa acctactgct 103680
cattgacctc ttgttccact tctctgagcc tccgtcacct cttcaccccc cagggtctgc 103740
tcctgctgta tggtgcctac ctggctggcc tgactggcca tgtcagctcc cctcctgtga 103800
atcagtcctt aaccatcatg gtgggggtca acctccttgt actggctgct gggctgcttt 103860
ttgtagtcac cagatacttg cattcctggc ccaacctggt ctttggactc acatctggag 103920
ggatctttgt ttgtacaact acaatcaact gcttcatctt cattccccag gtatggattt 103980
tgcagggctg gtcctcttag tcactctaga gtttttcact gacaaattgc tcattttgtt 104040
ttctactgat acctttccat gccacttatt ggagagtcag aaagcagaca ggggatccta 104100
gtgagctggt tgcctttgtc ctttctcact gtcctggtca gcaaggggga caaggcagag 104160
tggtccaagc agtggtggca gcccctgttt gcactcttcc acacctgtgg tgcctgtccc 104220
ttgggggggc tgcctcgcag tcctgctttt ccatccaccc tctggtctgc tgcactcgtt 104280
ccccatcctc ccctcatttc catcatgtta ttactatttc tttcactagc ctgggagcaa 104340
ggaaccttta tatttttcca attggggatt gcagactcac aggaaaaaat ccatttagat 104400
ggaactttat gatttaaagt gctttctctt tctttttatt ggaggaaaat acagaacatt 104460
tctctgcttt ttacaataag gagaggtaga aactaaataa aaatatgttt catattatgg 104520
ggattttaaa aaatcaaatg agggaggaag acagaagcag aaatagccag atagcaaaga 104580
agaaaggtag tcagagggaa cagagaagga atcctaggct cagaaagcaa ggggatgtgg 104640
gattgttcat gctacaccct ggggaccatc aagccacata tatctaggtt aatgaacttg 104700
gcactaggta ctttcttgtt tccctcctag ttctcctttt cttccctctg agacctccct 104760
catcccactc ctccttcaag accctgtcct gattcccatt gcaacttcca gttgactgta 104820
aactaattcc tcatgatgga gctaactgat aatgtaagtg ttggctgatg gcacgttaca 104880
gtgtatttgt gaaagggaag agtgcacttt gggtcatgat ggtatgacat gggcatagcc 104940
ctgttacgat tcttctctat cacaaatcct cattacagta ctcaacagaa tacataaata 105000
tggaaaaatc tgcagcagca gcactagaaa cgatggatgg ctattgcctc tgtgccagaa 105060
actggaggaa tttttgccaa atcttaatgc cgtaaaaact ggaatgaagg aagccattta 105120
gagctgaggc ttgtttgtct gggatgaggc agaaatgggc tctgagaagc aaggactgtt 105180
tctccctggg agaccggggg cgggggcggg gtgggtgggc aggggtaagg gtaggcaggt 105240
gccttttggg aagcccaccc cttaggccct gcagccaata ttgttggatt ggtagcgatc 105300
aacaatgcag agaactggtg ctgaagggta caaggcagtc ctgattccat aaacaagcaa 105360
gccctgcctg acagcagcct acctgttgac tgtcagggcg gagaggcctg gttgactgat 105420
tactggcaga ggaaaaggag gagtttttgt agaaataagt accctttaag ggtaaactct 105480
ggccaggcac agtggctcac acctgtaatc ccagcacttg gtgaggctga ggtaggcgta 105540
tcacttgagg ttaggagttc gagaccagcc tggccaacat ggtgaaactc tgtctctact 105600
aaaaatatga aaattagctg ggcatggtgg tgcacgccta taatcccagc tactcgggag 105660
gctgaggcag gaaaatcact tgaacccggg aggcagaggt tgcagtgagc cgagattgcg 105720
ccactgccct ccagcctggg caacagagct gctaacccct ttcttccttg cttgcctgca 105780
ctatagagac agcaacagct agactcttct tttgccagct tcccatagag ataggagtgc 105840
ctatatgaca ccattttgaa cactagaggt tttctgagaa gcttctgaga aagcttttgc 105900
tttcctgaaa aaggttataa gcatggctaa catcaccctt tttaccttct tcctgccttg 105960
aatgtatgtg attcctagag ctatggcagc tctcttgtga acataaggaa aagactaaga 106020
gaatatagtt ataatactag gaagatacag ctctttccat gtaagattat aaattctgga 106080
ggaaatgatc tatgaaggga atctgcagtt cacaagaaga ggactacaaa tgtctaaaga 106140
tttagagaag ctgccttcct ctggagtaga agtgtttaga agataccgga cttgtcaata 106200
gaattcaaag gatattgtct cttctcaact aaagcaaact atcatgaaaa aaagctaatc 106260
ttaataaaat attgaataag gattaaaaat atggtattaa atttaaaatc ccaatagaag 106320
cattgactgg gcaattagac actacaaaat attgaattag tgaattactt taaggaaaca 106380
gaaaataagg aaacaaatga gagactagat aagaaaatat ggaaaatggc cagatgcagt 106440
acctcatgcc tgtaatccca gcattttggg aggccgatgt gagcggatca cctgaggtca 106500
ggagttcgaa accagcctga ccaacatggt gaaaccccat ctctactaaa aatacaaaaa 106560
ttagctgggc gttgtggcat ccatctgtaa tcccagctac tagggagact gaggcaggag 106620
aatcgcctga acccaggagg cagaggttgc agtgagccaa gatcacgcca ttgcactcca 106680
gcctgggcaa caagagcgaa aatctgtctc aaaaaataaa ataaaaagaa aaaaataaaa 106740
tatggaaaac atctaggaat acaattgaga gctgatagga gtctctgaaa gagaacaaaa 106800
taatttgggg cagaagtcat tatcaaagag ctatcagagg aaaatgtttc tgaacaaaca 106860
aagccttggt cagaaaactg aatgaattgg caatctccat gatggcgccc tgcttactgc 106920
tcctctctcc atcctcacct ctcaccactg cccccttgca tcgtaagcct cagccacatc 106980
acttcccctt tgcctggtgt ttgagtcctc agcagctagg acaattgtga catctgggta 107040
ctctacacac aaaaatgcag aatgaagtgc tgcttgaaat ctgccttcca ggttttcact 107100
aagcaacaaa cacttgattt gttgaattgg gaatggaaat ggaatgatta tgaggtacag 107160
gaattgggtg gatggactgc actggccttg ctttccttct atctcactcc ctctttccct 107220
cctagctttc ttaagcttcc tttctcttac tctgtctttc ctcttccatt ttctcccttg 107280
tgtttttttt ttttctcctc tggaactaac tgaccatgat gtgaaactaa aaaatatatt 107340
ttgtagtctg ttgtatttta ggtttagatg gtaagtagtt ctttttcaaa atataaaaga 107400
aactgaggtt tgttaggttt ctgtgtgttt ccctctggct ccgaggtctt tggtagaaga 107460
acgattctcc ctgtgatact tgcactgtgt attcctagaa gataatttgg gaaagtaatt 107520
tgagtaaatt tgggaaagtg ggtgagggga actatctggg taagggttgg gggttgcagc 107580
aaaacggggt tccttcttgc cagtgagctt tcagacatga ctgtgatggg aggagtttgt 107640
gaaagcaaag gcacagatac ccccagggca gcgaggcagc gccagagagc gggtgaaatg 107700
gatgacatta ctaaggagac aaggggccca agaagccttc tttacacagg cactcaggaa 107760
atgcctgagt gtttatgcca agcactgagg tcatcactag aagtcagcca gccgctgctg 107820
ttctgacctg aatatgaccc atcccccagc cctctgctcc ctcagagagg caggcaggtc 107880
ctaaggtagg acattgtttt ctctctcctc taaccccgaa agcatttcat ctgctcctcc 107940
ctgaagatgt gcaggccttt ctaatctgcc ttataattat atgtatatgt cccagcaccc 108000
ctactagacc agtgagcatt ttaaagaaag cttccttcat ttgttcatgc atgcatccat 108060
ccatccactt attaactgct gggtacatgc acttaaacac agagtccgcc tctaggtcta 108120
gtggggagca aacatgaaag gaattatcat acatgtgtta agagctttga gaaaggcctt 108180
ccccagccca tctgagaact cagtggcacc ttctcagaaa atgaggctgg gcatggtggc 108240
tcatgcttat aatcccagca cttttcaagg ctgaggcggg tagatcgctt gagcccaaga 108300
gttcgagagc aacctggtca acatggtgaa acctggtctc tgcaaaaaat gcaaaaattg 108360
gctagacgtg gtggctcacg cctgtaattc cagcagtttg ggaggacaag gcgggcagat 108420
cacgtgaagt caggagtttg agaccagcct ggccaacatg gtaaaacccc gtctctacta 108480
aaaatacaaa aaattagctg ggtgtggtgg cgggcgcctg taatccagct acttgggagg 108540
ctgaggcagg agagttgctt aaaccgggag acaagggttg cagtgagccg agattgtgcc 108600
attgcactcc agccagagac agagtgagac tgtctcaaaa aatataaagc aaaaattagc 108660
caggcatggt ggtgcatgcc tctggtccca gctacccagg aggctgaagt aggaggatca 108720
cctgagccca ggaggttgag gctgcagtga gctgtgattg tgccactgca ctccagacag 108780
agtaagaccc tgtctcaaaa aaaaaaaaaa agaaggaagg aagggagaga gggagggagg 108840
gaaggaggga ggtaggaagg aaggaaggaa ggaagatgag gtgttcgagc tcagtcttga 108900
aggaaacata agagttcatt gaagagatgg gggaaagtag gtggcatttc tgatggaata 108960
acatcatgac cagaggcagg gaggctagaa agagagtagc gtatgtttgg agcaccatgg 109020
tctttgttat ttttgaagca caaatggaaa ccagggggag aatgacagga ctggggagag 109080
acacacctgg ggagcttctg aggccctgct ggaccctgtt aaagagttga catttagtcc 109140
caccatatta gtttcccact gctgctataa caaattccca caagcttagt ggcttaaaat 109200
aatacaagtt tattatctta aaattttgga ggtcagaaat ctgaaatagg tcttatttgg 109260
ctaaacttaa ggtgtcagga agtctgtatt ccctccagag atgcaagggg agaatctgtt 109320
tccttgtctt tttcagcttc tagaggccgt ctgcattctt gtgcttattg tcccctcctc 109380
caccttctaa gccagccagg ttcaaatctg ccagaagaga ttcaaatctt tctctctctc 109440
gcccctgttt ccattgtcac atctccttct ccaactctgg ctctcctccc tccctcctat 109500
aaggattctt gtgattacat tgggcccact tggataaccc agaataatca cccctcttga 109560
aatccttaat tacatttgca aagtcccttt tgccacataa ggtcacatat tcacaggctc 109620
caggaattag gatgagagag aacatctttg agaagccact gttcagtctg ccacaccccc 109680
atagcccaga ggctcagaaa accagaatct gcctgtcctt ctggaggaag gcagaggaga 109740
ggccctgaat tgtgaaattc atagctggat tccagaaacc ctgaagggtt gagccttaag 109800
gagtatcttc acaaatgagg aatgaagggc tagagtaatc aaggggtatc ttggctccac 109860
ttggccaatt tagagacagg aagaccaaaa gccctgggag ggcccttacg ccagtgctga 109920
gctgctcctc tgccagccct gcagagaggc ctcagtctgg gagtgctggg ggagatgaag 109980
gaaaagctgt actgcagcac tgccagggtc agtgtgagga gaataaccct aggaggtctg 110040
attcatccac ccaaggccac agatgacctt gtgttgttgg ctccagtagc tcccaagtag 110100
gatggtgagc tgagagcatc ctttcgtggg gagggggcct tcaagaaggg catctgagag 110160
gggaggtacc aggcctgacc caacacaggt cacacagact cctggtgcga tgatggactc 110220
atgatgagtc agcagaggac ccaagaggac ttgggtgata atatcaattt cagtggcatt 110280
gaaattgatg gcaggattca gaatcctatc tgagatttac aaaatttggt ttacactcca 110340
tggtcggagc ttaacaaatg tttgatggat gagtaaagaa atcccaggat ccctttgagg 110400
ctacccatag acactgcagc atcatttcta gaatcaaggt cccagggtcc ccagtgtcca 110460
tcactaggac acttagttat ggggattcct gagaggaaaa cagaggcctt ccccactgtg 110520
gcttcctgcg tcactcacat tactgtcatt cggtgggtca gcagtacccc acagactcag 110580
gcagaggctc ctgtttctat gttcagcttc attcctgtta aactaaacca gcccatgctt 110640
ctgcagagtg ttcctcaaga ccagtttctc ctgaagagct ttccctggac tgccaccgtt 110700
aacagtctct ctcttcatca actgagtgag gacacagaca tggcacagtg tcctgcttac 110760
agctgttgtt ctgctgctaa gtggctgtgt aagcttagac acaacactcc tgagcctttc 110820
ctagtttgtc aaagaaactg ggtgatgagc tagagcatcc tgatgtgact agggggcttc 110880
cctcaaaggc tctctgagcc ttgattattg acttgggtta gaagttcacc caaaggaact 110940
gaattttcaa tagcagcaag cacattgtta ctgaacaaat gaaaaataat taaatagctg 111000
catgcaacga gaaagtgtca tttgaaactt atagtgttca ggttgcttaa ccccaggata 111060
gctcctaact ctggctttag aatgtggtgg tagaagatac ttcagctctg gttttctttg 111120
accagtttgg caatgggtag gcagatgggc taaggctgtt ctattttatc tacctgtcct 111180
attcttcctt tggaaatttg tgtttgtttt tagggtgttt tgggtttttg tttttttttt 111240
ttaagattgg gtctcactct gccacccagg ctagagtaca gtatcacaac aatagctcac 111300
agtagcctga aactcttgag ctcaagtgat cctcccactt cagcctcctg agtagctggg 111360
attataggag tgagccattg cacccagccc tttggcattt taaaaattat ataaccttaa 111420
cattttgtat aattacaaaa ggtaaggacc ttttgtcatt accatctttg agccctccag 111480
agcaaagtac attttaagga gagaatagct tgcgcatgtg tgtatctatg atagtgtcat 111540
tccttggtgt ttatgagaaa gagtgagaga gtgtgtttct ggatgtgtaa ttaaataaat 111600
aacatgtgtt cttttatcta acagctgaag caatggaagg catttgaaga ggaaaaccaa 111660
acaatcagac gcatggccaa atatttcagc actcccaaca aaagcttcca tacccagtat 111720
ggtgaggagg agaactgcca cccgagggga gagaaaagct ccatggagag gctcctcaca 111780
gaagtaagct ctgcccctgc ctggaagatt ccctgtaaag gatccaatca tgcatcggtg 111840
gcccccaagg ctcttattgc tgatgttctc ttttcctctc attctcccac ttctcttaac 111900
agcaagcaaa acctcaccat ttccaccgtg acacgcatct acttcattca ttcagtggac 111960
agatgtataa tgagtcactc ctatgtgcca ggcattgtgc cagtgaacaa tgaacaaaag 112020
catggttcct accctcacag agctcacagt ctagtggaag aaatagagat tcattcatca 112080
agcaaacatg taattataca ttgtcataag aattatgaaa gaaaaatcag agtggtaaga 112140
cagaataatg tgtggtaagg gcaagaaaac ataacttaga ccagtcagaa aagactcatt 112200
gagctgaggg ctgaaggtta agtacaaatt agccaggcaa agagtacagg gaaaagtatt 112260
ccaagctgcg ggaacagcat tgtaaaggcc ctgaaatgtg gtggacacta gcttccctgt 112320
gatacatttt ctctcttttt tttttttttt tttttttttg agatgaggcc tcactctgtt 112380
tcccaggctg gagtgcactg gtaccatctt ggctcactga aacctccacc tcctaggttc 112440
aagcaattct cctgcctcag cctcccaagt agctgggact acaggcaccc accaccatgc 112500
tcagctaact tttgtatttt tagtagagac ggggtttcac catgttaccc aggttagtct 112560
caaactcctg acctcaagtg atctacctgc cctggcctcc cagggtgctg ggatcacagg 112620
tgtgagccgc cgcgcctggc ctcattttct ctttttacat agagtagtgt cttcatgtcc 112680
aagatctcct ggggtcctta ctgtctttcc caggtactgg ctacagatct caatcagccc 112740
atcatcccag aaagtccagg catgtctaca gatggagaag gggactaaac aagggcttct 112800
gaatgtgatt gtagcaccaa gggagaatga ggcagctccc ccgggcttct ttcttctgta 112860
tttgagccag agttggcccc tctcccagac ttgggcagtg tgatgcaggc atgaagaaag 112920
cacgtggaaa ggtttgaagg cttcgttgac tcaggaagaa ggcacagggc ccaggggagt 112980
tagtcagtat tttgacacta actgaattac attccatatt ttttcagttt agaacctatc 113040
tcaggaggtg ttatttggaa aactgggctt tttttttagg actgctgcct aggtattaat 113100
agtccctgat gagaggatag tgtggtgggg acctagaaaa cacaacagat gaagggactc 113160
agcacaccca ggcacccacc gttcatgccc ctctatggtt ctggaccatt tttgtccatc 113220
agagtaacac ctctccattt ctttactatt aagtatttca aagccagatt tctttccacc 113280
tggcaaggga gtaatattgc ctttgatact ctgtgaagtc ttcaaataag catttttttt 113340
tcctggctac acagaaggcc agaaacttgg ctagaacagc caggatagtt ttcattcaca 113400
gtcagctgat gctggaacag ccaagtggac tgactcttta gccttatggt aatttgcaac 113460
gtgctgtttg tacttctgcc atgctaccct gtttcccacg cagggactca atctgctata 113520
tccaaaaaga tgctttgagt ctgcagagga agcccttcaa tgggcacagg tgcacaagtg 113580
gtaagaagct ggcctcccca gtgcacgcta cacctggaat ctctttccca gaacaggcca 113640
gagaacaagc ggccagtcct agggcccggt ggcaggtgtc aggaggttcc agcatctgca 113700
tccccagctc cagcattgcc cgttagagaa acatgagtat ctctcctggc tcaacatatg 113760
tacagacctt gactctggcc catggtgtgc agtgccttcc tgtgcaggcc ccactccccc 113820
actcaggcct tcctcttact ttcccgtgat ctgggcagcc ccatcttctc acacttttcc 113880
ctcttgcctc tatagccagg ggtcccccca gaagctgttt cggacagcat ctatcacatc 113940
tatcactgac ttccctgtct aagagaaggc cagcagacag aaccttccac aaggctgaag 114000
tgctttcctc atacactctg cagccaagta aacaaaccta ttacttttgt tacctgaacc 114060
atagaaacaa gaggctaatt ccatgtctcc ttatggcctg ccccctgtga aacatgcagg 114120
tggatgtttt gcttccctca atatgccaaa aataataatt aataagctca ttgaagtgca 114180
gctgccgtgg taggtcagat ttcagtctca taatggcagt gcctcacacc acacctctaa 114240
ttagtatgca gccatggtaa aaacagagtc ccacttcttt ttctggaaga aggaaatttt 114300
ctgtttaggt tgatgtttct aaatctgtca ccagccagct tcttcccaac tccatgttta 114360
tagtatcttt ctatactcaa aggagtttat agataaggca caaaaagaca gcactcagat 114420
ttcacccacg ggagtagttg ccatctgccg atgggtcctt cctaactctg tgaggctata 114480
gaggcctcca gaagcccaca tgagaatgtg cacgatgggc ttcaggagga gaggctggtg 114540
gaggagggag ttgaggtccc cccatgagat cctcagagag atgcctggca cagcccagga 114600
tcacaaacac ctgagtgttt ccctattgct catccattct gcccctgaca agtccttgag 114660
tcatctgcac tcacccagca acacccagac ctcaccactc tgcgggcaga gggaagggag 114720
ggaggacagg cacacatgtg ctcagctgaa agtctcttct accttactca ccagtccctc 114780
actggccctg gactctcttc tgatggtaaa agaagtatac tcaaccaggg tgaaactagc 114840
aataccaact atcagaaaaa tcaccttccc aattctacaa ggggagcagt gcatctgctt 114900
ggagagttgc tagtcagaat attggactat tttgcttaag ctactgctcc cttaaaggat 114960
catttctagg caactctccc atgtaaacct gagatgaaac cacaggttca ctctataact 115020
agtagtccta gttagctgtt atggacggta taactaggca atttgtattg gttatcctaa 115080
cacagggaac atccttttgt ttctagggca taataaatgg aggtccaaat gctcatgccc 115140
agctcctaaa gatgatagta acaaagaggt agcattttgg tgttcagaca agcactttct 115200
agaacatttg cttacattat tgccttccca gaaccctcga ccccatgtca tctgccccaa 115260
gtccagacgt tccctgtgaa tatctcctcc ctgctctgcc tttgaggatc agaagtttcc 115320
agagatggac acacagtctg aactagagaa tcagctgctg caccacagaa agatgtctgg 115380
gctgcagtcg ttccctgcaa cccactgcca acactcctac tcctacttca tgccccacaa 115440
tctcgcagtt aggacaggca cacctctgca gctctcacct gccagccctc tccggcacaa 115500
cttgtttacc agctaacatc cagcgagtag gcaggtcagt agcagaactg ccccaggctc 115560
cttcgtctcc tgggctccat tctagggctg ctgaatcaag ctagcagggg cttaagccca 115620
acagtccttt catttctttg tgcttcttca atagttctga tgcttgcact cctttaggtg 115680
agtggttccc aacatttttg gcaccaggga ccacttccgt ggaagacagt ttttccacag 115740
atagtggtgg ggggatggtt tcgggatgaa actgttccac ctcagatcat cagacattag 115800
cttctcataa ggagtgtgca gcctagaccc ctcacatgtg cagttcacaa tagggtttgc 115860
gcttctgtga gaatctaatg tctcagctga tctgatggaa gctcaggtgg taatgcttcc 115920
tcacccaccg ctcacctcct gctgtgcggc ctggttccta acagtccatg gactagtact 115980
ggtccgtggc ccaggagttg gggacccctg ctttaggtga aatcaacagc tgatattgcc 116040
acatggtagc tttggccact cactcccaga ggtccagcct agggaggtga taacaccaac 116100
ctgagattct ctttggcccc tctcagctcc aatcttattt gattgtcaca gaaatctcca 116160
cccttctcct tgttcttccc attttctagg ctgtttagta agaggcaaaa tacttgttct 116220
cctacttctt catcccctgg agatatgctt cacatttatc taaatttttg caaaagtgtg 116280
ataaactcca agtgggacca ttccaaacat tattcagctc atacctgcgg agtggcctga 116340
ccctctcagt tctgggaaag gtgagagggc gctgcagtgg ccagcaggca ctcagactgg 116400
gcctccttgc tcttcataag caatgccgca cagtgtgggg atgtaaggag aagaccaaga 116460
taatgacaat aaatcatggt tggcctttat tgagcaccgt ttatgtcagt tattgtgcta 116520
gcactttaca tgcatcaact catttcactg gagggaggca cctccttaga acctgaggtc 116580
accagccaat acactggaag aactgagatt tcagccaagg ttctttgaaa gccacacctt 116640
ctccaccatg gtgggcacta tggaaccctc ggcggcatct tttgttgatg gttttgcttt 116700
tattttacag aaaaatgctg tgattgaaag cctgcaggaa caagtaaaca acgccaaaga 116760
gaagattgtg aggctgatgt cagctgagtg cacctatgac ctcccagagg gggctgcccc 116820
acctgcctct tccccgaaca aggacgtcca ggcggtagcc tcggtccaca ccctggcagc 116880
tgctcagggg ccttcgggtc acctctctga ctttcagaat gatcctggca tggctgcccg 116940
ggattcccag tgcacttcag ggccctcctc atatgcacaa agccttgagg ggcctgggaa 117000
ggactccagc ttctccccag ggaaggagga gaagatatct gactcaaaag acttttctga 117060
tcatttagac tcaggttgta gccagaagcc atggactgag caaagcctgg gtccagaaag 117120
aggagaccaa gtccccatga accccagcca gagtctccta ccaganagag gcggctcaga 117180
tccccagaga cagaggcatc tggagaactc agaggagccc ccagagcggc ggtcacgggt 117240
tagttcagta atcagggaga aacttcagga ggtcttacaa gatctgggcc tgggccctga 117300
ggcttccctc tccaccgccc cctcttgtca tcagcaaacc tggaagaaca gtgctgcctt 117360
cagcccccaa aagatgcccc tctccaagga gctcggcttt agcccttaca tggtgaggag 117420
aaggcgggca gctcagcggg cccgctcaca ctttcctggc tctgcaccct catctgtggg 117480
gcatcgggca aacaggactg ttcctggggc acacagcagg ctacatgtgc agaatgggga 117540
cagccccagc ctggccccac aaactactga ttccagagta cgaagacctt cttccaggaa 117600
gccttcacta ccttcagatc ctcaagacag accaggtacc ctggagggca gcaaacaaag 117660
ccagacagag cccgaggggg ctagagggag caaagcagcc tttcttcgcc agccttctgg 117720
ttctggccgg gccccaagtc ctgctgcccc atgcctctcc aaagcctcac ctgacttgcc 117780
tgaacagtgg cagctgtggc ccccagtgcc ctcaggctgt gcctccctgt cttctcaaca 117840
cagctatttt gatactgagt ccagcagctc agatgagttc ttctgccgct gccaccggcc 117900
ctactgtgaa atctgcttcc agagctcttc tgactctagt gacagtggca catcagacac 117960
tgaccctgag cctactgggg ggctggcttc ctgggaaaag ctgtgggccc gctccaagcc 118020
tattgtgaac ttcaaagatg acttgaaacc cacgctggtg tgaaaagcaa cagagctggt 118080
ctagacacag aggtcagtcc aagagaagct gtaccaaggc ccacaggaga agagccaatt 118140
tctggtcttt ggggaacaga ttagtgccct gcatttgacc agcccatacc atgtttcagc 118200
taggctcact gtgttacttt gagtacttct tgatctataa aaagagaggc attgcctgtc 118260
ctgttactac ctcgcagcct tactataaaa gactccagtt gagtgactat gaaagacact 118320
gactccttgg ataaaaggtg ctgaatgaac acataggatt ttctgtccag gtcagcctac 118380
attctgtaaa actcttaata tattcagatg gatggctgaa tggacagaca gatggagaga 118440
tgcatgggaa atttctgtag aacttgaggt gtggactgtg acccatcaaa ctggcctttt 118500
ggtggacaga cctaccagga agataagtct cctacatcct tgggcctccc actcctggaa 118560
ggcagtggtt ttatttctgc tgaatgttgt gaacagcacc tccctagatt ccagcttctg 118620
gccagaccca gctcagagcc acccctacac cactatttct tgatggtgtc tttccaccat 118680
tatggcactt taccctcctc tctgagacag atctccatgc gcccgcaggc ttcccagatc 118740
tctcccctgg gatcggatgt acctgaggtc ctgactgtcc ccactgtccc cttgtcctgt 118800
ggctcatcct cgattcaccc actgatgcag ttttgtactg cggggaggca cacaccagca 118860
atttctgttg gggtatggga gaacctgttg gtcaagagtg cttttggttc cattggggtt 118920
acatgactac caacagacac ataaacctgg aagccaaatg gagaaataaa aaggaagaca 118980
cgagggacac gaaaacagga aagaaaacag gatttgaata tttcacttga gtccagcata 119040
gtacttggca atatcatatt tttgtgattc cttttgataa ccctgtgaag tagacacttt 119100
catttttaca gacaaggatt atgaggctta gagaaatgag gtagtttccc gcaacatcac 119160
actgctggac agagatgtac acacagctcc tgggactcaa gtaggtgggt tttcccaggg 119220
acacatggct tcatgtgttc ttctgggaat ggcaggtgac gcttggcaga cgagacaaca 119280
aagcaaggct catgtaagaa agctgggatg tgctccccta tagtccagaa taatagacct 119340
gggtcctcac ctcaggaaac gggcctccac ttcctcactg ccaaaggcca cactggcacc 119400
tcccaaggga gctggggagc tggtgaagga tgagtgcgag gaactcagcc accaccagag 119460
ccacagggag agcacacctg ggtccactgt gcttattgct gagctggctg tcatgtccag 119520
gctgtcccct gccccgagtc ctgtgtatac atctgtgggt gtgcacatgt ttgcatgaag 119580
gaattcaggc cttattaaat attctcagag gggggcattt ggctctaaat gtatcatcaa 119640
tttatcatgg aatcttgggg gctgctgaca cccctggact ctccaggcac tgaaccatga 119700
ggccctcctg gaagcacagc ttcttctatc atctactttt aaacaggaat ttcctaattt 119760
attctgtgca tgggtttgca gtttcttgtg ctgtgtgtgt gctgtccaag tggtaccata 119820
ataaaagaga aatgactccc gagaggagtc ttttcagaaa ctgtaatctg gggctggcca 119880
ggaggggccc ggagaaggct gacccaccca aagaagggga accagagaag ccatcagagc 119940
tgctgccggg ctaccctggg tcccagtgta ccttctacca aagttccatt tgaacagatt 120000
cttctgtgtt ctccctaaga agcctcttat cccagaaaca ctccctcaat ggacatagga 120060
aaccctggag accctggact cttcctgccc ctgggggtcc tgtggctggg ctccccctcc 120120
tgcagctccc ttcctcccag catgccacca ctagcagccc accattcatt catgtggact 120180
ctaaatctgg caatccttct agccttctca ctctgtctgc ttctagaacc ttagtcccac 120240
catccccgcc cttctacatc tccatccttc tgtttagaat tttttttccc actttgtgcc 120300
cttgtgaatt attcatcctt caaggctcag gtggagcata cattctttct tcaacctttc 120360
ccagccatcc ccaaagaaag ctgattgatt ccctagttaa ataaggaagg atgggctgga 120420
agcagtggct cacgtctgta atcccagcac 120450
<210> 8
<211> 120438
<212> DNA
<213> Homo sapien
<220>
<223> Wild type GPR156 isoform 2 genomic DNA
<220>
<221> variation
<222> (117154) .. (117154)
<223> n is a, g, t, or c
<400> 8
ggggaccgtg ggcgtcctgc acatagcagc gggcttggcg cttctcggcg gtccgacgct 60
gatgaggtga gcacagcgac cttaaggatc cacaaaactt caaacactta attattaagt 120
gaaagtggaa agggggaggg gctttctctc cctttccaga atctgggcag tttgtttgga 180
accggtaaag aaactctcat aggaacttga ggtgagcagg ggtcacgcat cagggatgcg 240
agtggcaatt tcagtggaag agacgggaga gtactgtaat ttggtgtgaa gatggggccg 300
tgggttttct gctgaataag cgaccggctg tgctgaaaat gagagatccc gaaacagttt 360
cccaccgcct gtagactttc cagagtctcc tcacgccgaa tctgctttgc agggcatgtt 420
cacccccagg gtgtagagtg gcgggcacga tgggctcccc catggagatt gcaaagtcct 480
gaaaagggac aattgtattg cactgcgtct gttgaactgc cttgcttctg ggcatgaggg 540
agtcacctgg aagctgcaac atccttgtac cctggcaagc agccctttcc aagttagctc 600
tgtcagaaac tagaggcctc taggtagaac tcaaggtatc catgtactcg tgaagaatac 660
aaaccttgag gtttttaaaa tcgaattttg ttaagatttc aggatagaaa tctgggaaga 720
gaagtcatgg catggcataa cttacccctt tgttagtttt ctaggtacat gcatgcttga 780
attagaggta aatgatgccc tagcctatca taaaatgtct ttcctggtgt agttctttaa 840
accagaatat ggaggataac attacatttt tgcatcctag ataaaaggga aagattttca 900
gatggggctt acacagcggg agaaattgtt gatatagttg tattaggcag caaggcctgc 960
aaagaaaaac ttctttttct ccaccagtgg ctgaattctg cacagaatgt ctcctcgcag 1020
tctgggtagc agcccggctt gcaaaaacag tgcttctttc attgctgcag gtggggcaaa 1080
tgcgcttgcg gataaatggc tggggaagcg tttgcttaca ggttaaggca atttgagtct 1140
ggagaataaa gtgctttagc aggctgtgct tgagttaggt gtcccttgtg aggaatagag 1200
gtggctttct ggtccccatt ttgccagcct aattcccctt cagggacact actgtctctg 1260
gaatgttccc tctgtttccc cttctcttcc acccccagct tttagcttct ccccattccc 1320
cagtaaagtc tagaattgag cctggtcaga gtcaaagttc tgatagccta gggatataga 1380
acttcaagcc tggtgaaggc agaaatgaga cctaggagag acccaagatg ggtgagatga 1440
aacaactttc agcctagaag gctctcaaaa gagtggaaaa ataatgattg agggaaacag 1500
attctctgga aaggagaata ggtgcttaag tgtttgtttt cagctgaggg ttttaatatt 1560
tccatttttg ttgtttaacc ataagggaat ttccattata gggtaggagg aggatgaggc 1620
cttctctgaa aactgcatcc ttctccttga atttgcattt tattccattc ttatgtaggt 1680
ttcagagatt aattggggga agggggagag aggaaagaag ccagaggctc tgacatgctg 1740
cagaaacagt gcaacgtgga ctgacttggg ctgcaaaggt ggatttgggg gttgaaagaa 1800
atgttctaca tttagttgaa aaaaaaaaat cagagccttt attttgcaaa ggtcttgaga 1860
atcagaacat tcatgtttag ttgctgatga attttgcctg ataaaggatg caaatcacta 1920
tctcaccttt ttttctccag tactttatta tgaaaaattt tagacataca gagatgtttt 1980
ctacctctca ttttataaac ttattatctt aaaacaaact tgttaataaa aatcagtgtt 2040
tagaatccag acatatgtga tctggtcctg gacagagctt gaatcagaag gtgtttcaaa 2100
tatagatgtg tgaaggatat taacatttta agaaaaaaat atggatctta ttcttctgac 2160
tttcccataa gaatcttgag cagacccctt aactgccttc tttttcccat tcttaaaatg 2220
tcagtcagtt ggatgatatt actctcctgc ttaacaccct ccaatggctt cccctcacac 2280
tgtgaataac attcaactct ccaccagggc ttgtgatttg gtctggtgcc ctcatattct 2340
atggccgtcc tcttgcttac catcgtcctt gctcttccct ctgcctgaac actcttcctt 2400
cagacactgc cactgcttct tttctcagct cattccagtt tcttttcata ctctccagaa 2460
tgatggccac ctgatctaaa acagcctgtg gtcactccct gtcttctgac cctgctttat 2520
ccttcttcat ggcacttagc actccctgac actatatagt atatgtgttt ccttgttaat 2580
tgggcatgtt ccccactcta atgtaaactc catcaagaca aggaattttt ttgtcttatt 2640
tatggctgtg ttcctatttg gtatattatg agcaattaat aaataactgt tggattaatt 2700
aggtaactaa attacacaaa taaggcattg actcccataa gggtggcaga acccttggta 2760
aaatactaga agtcctttga ggtaattcat aattcaagtt aatcaatatt tgataggtaa 2820
atgatgaccc tggagatcag tggcctcttt tatcctcaca gcacttctca gctgaatcct 2880
atgctaatag ctggccagtt ttgacaaacc cacatcccaa acaagacata aaatatttca 2940
gtcacagaac ttttcctcac gtctctttct agtcacctcc accccacaga agcagcaaac 3000
cttgttctga tttctaatat catagattag tgttgctggt tcctgaattt catataactg 3060
cagttacaca gtatgcactc ttgtgtttgg cttctttttg ccctacacaa tgtctgtgat 3120
attcatctgt gccattgtgt gtatcagtag ttcatttctt ttttttccaa ggtagtattt 3180
attgtatgaa tattgaccat gtgtttatct gttctcttgt tgatagatac ttggttgttg 3240
ccagtttgtg gcaattttga acaaagctgc tgtgaaccta taaagggtct gcctcatctt 3300
gagtcttctc tactttatat gaaaatcttc cttgtgccac caatgcagag agaagtatgg 3360
caaggttatg ggggctgtga ctgatgtagc agcttgcatg taccccagcc agtgctctct 3420
ctagacagct ctgctgggag ctgacctgct tcccacttta gagggaaagc acttggaaaa 3480
tgagtgtcta acaaattagc gagccctcca gtgcactctt aagtgcttta aatccttgaa 3540
agagacactg tggaatgcct gctgccatca ctgttgtatt tccctcctcc tctcagcttc 3600
cccatcccag cacaagttga ctctaatcag cttctgagca ttatgctact gaggggttta 3660
aacattcatg agcaagagtc ttgttcagag cctgataaaa tattcatgtg tttccatggg 3720
gcattggttt ccatctagac ttctcaaggc atttttctga gatgcatgtc gtaattgtga 3780
agaactcaga cagtgatgga tgatacggcc ctgtgttatt aaaccctacc acacagagca 3840
ccttgctttc tagggatgga gaagaatgag cacacagaaa aattgacatt aatcctgtct 3900
agatcaagag aaaggctaca tgtactgata aaaatggctt gagtaaagag gggcctgtta 3960
atatagtacc aacaaaggta tgaatccata gaggagagtg aaaagaactt gttaaaatga 4020
gaggaatgct gggatgcagt cattccaagt ggaagaatgg gggaatcagc attgtaaaat 4080
gcacagttcc tttgacactc atgtggacga ggttcatatg agacaactgt gctgagtgct 4140
gtaattatca caacctgcta tgagaggatg agagtagaag tggaggctag gcagggtttc 4200
caagtagagc cagagagcta ttccaagagg agtcaacatt tctcttcaag gaagaagtgg 4260
ctttgagtca ggttctgaag gaggtgtgcc tctttgactg gcagctgcgg tgtggaaggg 4320
actttccaga gagacagaat agcatgatag agtgagggcc aaagtgccgg tgtggtgtga 4380
gtaaggagag aaggtgggtg gatgggggtc agggcagggt tgcagcaaga cataaagcag 4440
gagagctaaa ggccagctta tgaaggccac aggaggatgg acttcagtct gtttgctgga 4500
gggccgtgta acttttggcc agagattggg ttacattttg aggagttctt gggaagtata 4560
tccaccctag gcaaggcctt gaggtatgtt tatgtccaag gcatttccag aatattctgc 4620
tgtgtccaga acactatgaa gactctacgt ggtctactct aagagaggta aaccagagga 4680
ggtcagatat actcagtata ctcctgggac tgaccagaaa caggcctcac caggcacctc 4740
tctgccccca gcacacaaac actcagaata ttctgagtca gattgaatcc acagcattcc 4800
ctagacttct tcatgaccac tttgcctcag ctgggggagt tgcaatgatc taagtatccc 4860
cttatcacct gaatctgggc caggatacct cagacatggg ttgccaggca actgagggct 4920
aagtgatgca gctggccaat catccccaca aagcccaggt ctgctttgac caggccatcg 4980
ggctgtgacc agagaggcaa cttggggggt tgaggtcatg cagactgatg acttgtggac 5040
acaactgcca ggccccttcc atatgtcttc ttcctttggg ttgcagattt ctattcaaaa 5100
atgcctcagg atgttgattt tttaacccat aataaaaata gtgaagtagg gaggagtgtt 5160
aaacatgtca gtcatctata ccttatgttg tcattgggaa gaaataactg tggaaacaat 5220
tgtcccggga aagtcagtct tcagtcttgc agtgaggagc tttgcatatg tggagattag 5280
ctagaaagct ctggagttct gatggtgaga agggatttct tgggtcaagg ataggaaagg 5340
gcaagggagg accttcatga ttctccccag ggctttgctg gttggaattg ctcttctgct 5400
gccatgggta gcatggggtt tcagtgactg aaaacaccca ggaaagtatg ctctgggtct 5460
tcatgttgcc atctgcctac actggaatgt cagaccatca gtcagcactg ccagctctcc 5520
atcttgattt tctaagagtt attgagaaaa ccttgaaagg gaaggcagaa gtgggtgtct 5580
taactaggga aatgccaagg tcctaaaggt gtggtctagg ttgaaggtgt ggtaagggcc 5640
tgaagtcatt ggtctggcag tacttcagac caataaagtc tttcttggct cttatctaaa 5700
atattcctga ttttctgtgt gaggtggaat ctctcaagtg ctgcattaat cagtcttttg 5760
gctgaacagg taaatagggt gcatgcttaa ttgagtgcct tttctttttt taaagtttca 5820
gcttttattt tacattaaga ggatacatgt gtaggattgt tcatgggtaa attggaccca 5880
ggcataagca cagtacccaa taggtagttt ttcaacccat gccccctccc tcccttcccc 5940
ctgtagtagt ctgcagtatc tatctttcct gcgtttatgt ccatgtgtgc tcagtgttta 6000
gctcccactt ataagtgaga acatgtggta ttttgttttc tgttcctgca ttaattcact 6060
taggataggc ctccaactgc atccacgttg ctgcaaagga catgatttca ttatttttta 6120
tcctatggtg tttatgtagc acattttctt catccagtac actgttgatg agtgcctagg 6180
ttgattccac atctttgcta ttgtgaatag tgctgtgatg cacatatgca agcatgtgta 6240
tttatggtgg aatgatttat atttctttga atatataccc agtaatggga ttgctgggtc 6300
aaaggtagct ctgtatttaa gttttttgag aaatctccaa actgctttcc acagtggttg 6360
tactaattta cattcccacc aacaatgtat aaatgttccc ttttcttcac agccttgcca 6420
gcatctgttg ttttttgact ttttaataat agctattctt actggtgtga gatggtatct 6480
tattgtggtt ttatttgcat ttctctgatg attagtgatg ctgagcatgt tttcatgtct 6540
attggccaca cttgtatgcc ttcttttaag aagtgtcttt tcatgtcttc tgcccacttt 6600
ttaatggagt tatttgattt ttgcctgttg atttaagttt cttatatatt ctggatatta 6660
gacctttgtc agatgcatag tttgtgaata ttttctccca tgctgtaggt tgtttactct 6720
tttgatggtt tctcttgctg tgcagaagat ctttagttta attaggtccc acttgtcaat 6780
ttttgttttt gttgcagttc tttctgggga cttggccata aattctttgc caaggccaat 6840
gttgataagg gtatttccta ggttttcttc tatgattttt atagtttgag gtcttatgtt 6900
aaatctttaa tccattttta gttagttttt gtatatggtg aaaggtaagg gtctagtttc 6960
attcttctgc atatggctac cagttatccc agcaccattt attgaatagg gagtcctttc 7020
tccattgctt gttttttgtc agccatgttg aagatcagat ggttgtaagc gtgcagcctt 7080
atttctgaat tttctattat gttccattag tctatgtgtc tctttttgta ccagtaccac 7140
cctgttttgg ctactctagc aaattctttg gaattaagga aaatagggac acaatttatg 7200
aagacctctg ggatgtagcc aaagcaatgt taagaggaaa gtttatagcc gtaaatgcct 7260
tcatcaagaa gctggaaaga tctcacatta acaatgtaac tttgcattta aaggaactat 7320
gaaaaaagga caaaccaacc ccaactctag cagaagaaaa gaaataacta aaattaaaga 7380
aaaacttaat gaaattgaga tgcaacaatc catatgaaag atcagtgaaa ccaagaatag 7440
gctatttgaa aaaataaata agattgatag actgctagct aggttaacaa agcgggagga 7500
gacagtgaga gagagagaga ggatccaaat aagtacaata gaaataacaa agatgacatt 7560
acaactgatc ctatagaaat acaaaagatc cttggagaaa actatgaaca gctctatgca 7620
cacaaattag aaaatctaga agaaatcaat caattcctgg aaacaatctc ttgagattga 7680
atcggagaga ttgaagtcct gaatagacca acatcaaact ctgaaattgc atcagtaaaa 7740
caaacaaaca aacaaaaaaa acccttccaa ccataaaaag ccctggacca gatagattca 7800
cagccacatt ctatgagaca tgcaaagaag aactagtacc aatcctacta aaacttacag 7860
aaaatagagg agcagggact cctccccaat tcatcccatg aagccagcat cagcctaata 7920
cccaaatctg gcagagatat gatgaagaga tatgattttt gtgtctatgt tcagaccaat 7980
atccctgatg aacatagaca caaaaatcct caacaaaata ctagcaaacc aaatttagca 8040
gaacatcaaa aagttaattc accatgatca agcaggcatt attcctggga tgcatggttg 8100
gttcaacata cacaaatcat agtgagtcac catgtaaaca gaattaaaag caaaaaccgt 8160
tatgatcatc tgtgtcatct caatagacac agaaaaagct tttgataaaa tctaacatct 8220
cttcatgata aaaactctca acaaactagg catcgaagga acatacctca aaataataag 8280
ggccatccct gataaaccta cagctaacat catactgaat gggcaaaagc tggaaccatt 8340
ccccttgaga actggaacaa ggcaagaatg cccactctca ccactgctat tcaaggtagt 8400
gctagaagtc ccagccagca cagtctggca atagaaagaa ataaaaggca tccaaataag 8460
aaaagaagaa gatgaactat ctccctttgc tgacgatata attctatact tagaacaccc 8520
caaagactgt tccaaaaggt tactagaatt gaaaaatgat tttagcaagg tttcaggata 8580
caaaatcaat gtacgaaaat cagtagcatt tctaaacacc aataacgtcc aggctgagag 8640
tcaaatcaag aacatgatcc catttacgac agctgcaaag aaaaggaaat acctaggaat 8700
atagcaaacc aaaaaggtga aagagctctg caaggagaac tacaatacac tgctgaaaaa 8760
aagttagaaa caacacaaat aaatgaaaaa atatcccatg ctcatggatt agaaggatca 8820
atatcattaa aatggtcata ctgcccaaag caatgtatac attcaatgct attcctatca 8880
aactactaac atcagtcttt acagaattag aaaaaactat tctaaaactc atatggaacc 8940
caaaaagagc ctgaatagcc aaagcaagcc tgagcaaaaa aaaaaaaaca aagccggagc 9000
atcacactac ctgagtgcct tttctgaaca gatatttcaa tgattctgtg attattcatg 9060
agccagtgat ggctgcctgc ttttggatgc tgctaggata aatgcagaag atcagagtga 9120
agagggagag ggaagcataa cagcagcaga gaggaaaagg gaagagagta gtgacgtgct 9180
gaaatcgcag agattgtggg tacccagtta tctacaagtg agaaacaggg ataaaagaag 9240
atcaaataac tacccatggg aattttacat gcaaatattg ctgacttcca aggcagctgt 9300
gaggagaaag gaagggagga gacacaaagg cagctgtcac agtcaatccg aggaatatta 9360
ataaaaactt gacacatgaa aacacatggc cgtatcacaa cagcctgggt cccagcaagg 9420
atgtctattc aaacccctct ttcacatttc cttatattca ttcacagtat taggtatttt 9480
gcaagacatt catttgcact tgcaaagata cacaaatgca gagtacttaa aagggtaaac 9540
tatcctaaaa tattagtggt gagattataa atgattattt gtattttttc aacttatcta 9600
tgttttccat gattgtttta agaagtgtga atttctttga taatcagaaa aacattaagg 9660
agaaaggggg ttaagtaggg aggtagagaa agaggcatgg ggtggggaga gaggattgta 9720
gaaaagaaaa atatgttgga agatgaatga acaattttaa aactttatgt ttcacagact 9780
gctagcttgt gcatattttt ctttattatt gaatatatat gtttatcacc ctcagaagat 9840
ctggaagtac caattggcat gaaactgaat tgcaaatact gagctaagta tcacacctcc 9900
aagaccattg ccttggccag tgccattctg tgtgtgacat gtggcttcca gtgatgctca 9960
aagtattttc cgccaaaggc taatagagaa cacttcaaac ctgggcagca gcatctctcc 10020
cacagggttt aatatttata cttgtagcca cgtggctggc tttgtgcttc tcatctctga 10080
agtatggaac aggagccaac aaaggctgtc aatagttgga gtagtgggat tttccaagac 10140
aaaagcgtga gttattctcg tccacgtgtt tgctggctgc tcactggctc aggcagcccc 10200
ttggcaagct ctgtggctga ggctttaaat aaatagatgt agtttttgtt tcacaaccac 10260
tgaccttttc tggaggcact gttgattctg ggctttaatt ggcttctgtt gagtgacaca 10320
aggtgaaccc tctcttcaag agcagaagct cctatctgct gttaaccacc agcatcaatt 10380
caaagcaaat gccagaggac cacatacctc actgaactct ggggactggg gttacttgta 10440
gttatgtctc aataaatact ttttatattt taacttttgc atttttaagt tgtaaaagct 10500
atacacactc atggtaacaa gtctagtaag acagcagtat ataaagaaaa tatggccagg 10560
cgcagtggct caccccatag ttccaatact ttgggaggcc gagatgggtg gatcacttga 10620
ggtcaggagt tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatta 10680
ggctgggtgc ggtggctcac tcctgtaatc ccatcacttt gggaggctga ggcgggtgga 10740
tcacaaggtc aggagttcaa gaccagcctg gccaagatgg tgaaaccctg cctctactaa 10800
aaatacaaaa attagctgag cgcagtggca ggcacctgta atcccagcta cttgggaggc 10860
tgaggccgga gaatcacttg aacccggggg gcagaggttc cagtgagccg agatcctgcc 10920
actgcactcc agcctgggcg acagcatgag actccgtctc aaaaaaaaaa aaaaaaaaaa 10980
attggccagg taaggtggct catgcctgta atcctggcac tttgggaggc cgaggtgggt 11040
ggatcacctg aggtcaggag ttcgagacca gcctgaccaa caaggtgaaa tcccatctct 11100
accaaaaata caaaaattag ctggacgtgg tggcaggcgc ctgtagtccc agctactcgg 11160
gaggctgaga caggagaatt gcttgaacca gggaggcaga ggttgcagtg agccgagatc 11220
gcaccactgc actacaacct gagcgatgga gcgagactct gtctcaaaaa aaaaaattag 11280
tcaagtgtgg tggcgtgtgc ctgtaatccc agttacttga gagggtgagg cgggagaata 11340
gctcgaaata gcttgaaccc aggaggcaga ggttgcagtg agccaagatt gtgccactgc 11400
actccagctt gggctaccga gggagactcc atctcaaaga aaaaaaaaaa gaaagaaaat 11460
ataagtaatc tccaccttct ctcactccca tctttctgac aaaaccacta tttaaagcgc 11520
ccaggctggg cgtgcgggct gacatctgta atctgagcac tttaggaggc agaggcagga 11580
ggatagcttg ggtccaggag ttcaaaacag cctggacaac atagtgaaac tccgtctcta 11640
tgaaaaaaaa aaaaaaatag ccaagtgggt ggtatgtcat cctagctact tgagaggatg 11700
aagtgggagg atcgcttgaa cccaggaggt tgaggctgca gtgagctgtg atcatgacat 11760
tgcactccag cttgagtaac agagtgagac cctgtctcaa aaaaaaagtt tcatgtgtat 11820
tcacatgtca cgatcacagc tcactgcagc ctcaacatct ccagctcaag ggatccttcc 11880
acctcagcct gccaaataac tgggaccaca ggcacatgcc accacacccg tctaattttt 11940
aaacattttt gtagaaacga ggtctcactg tgttgcccag gctgatcttg aattcctcgg 12000
ctcaagtgat cctcccacct cagcctccca aagtgctggg attataggca tgagccactg 12060
cactcagccc cttcactcct tttctatgtt caaacaaaca tatgagtgtg tagacttatt 12120
ttctattgta tgtgaaaatg gaatcatata tgttattatt tctttcattt tatttagtac 12180
atattatgta cattattcta gattaacaca tataattgat ccaatttatt atttttaata 12240
gctacctaat attccattat aggaggttcc ataatttctt cccattcatt acttccccat 12300
tgatagatat tcatgttttt cttccaactt tttttgcaca acaacttatg ctacaataaa 12360
cattctacat ttattcctat actttgggtt ttatttccat aggagagatt cccaaaattg 12420
tcatttttgg gtcaaaggga atacacaatt ttaattctca ctgtaggtct cctttacagc 12480
agttgtttct ctcctccttt tgtctttctc tcccctctcc caccacattt tgccagcagg 12540
gcctgtgtgt ttaagaagga aagcctgcag tgagaactcc tctgtgccaa gtgtggatta 12600
tatcagctta gtggggaact ggagtctgca gtgtctcagt tacattgtgt ctctcttgct 12660
tttggttggc cagactgttc acaattcccc ttgctgattt attccatgct gtggaattat 12720
acatggtctt catccgtggc aggatcatct gaggggtggc tttttgggaa gggtgtcttt 12780
tcagaaagaa taggctcagt tactgtactt tctcacaaag ctatatctgt tatgtttttt 12840
tgttatgccc tttctttaat agttggattg aaaaaggttc ttcaattccc atcccggtct 12900
tctgtcttca ttttgaggac ttgggattta gggagtttta tgagtatata atcaatcaac 12960
tgtaactgat tatttgacat gaggataatt agttaagaag gtaggggtct tggagcttaa 13020
ggatcagtgc caagcaacag acgtgaacat ttttaaacaa atggttttaa caaacccggt 13080
attaggagca agcttcccag gagtactaag ctttcatttt ttaattttgc ccttgctggg 13140
atgtaaaact tcagtctagt ctaccagaat agagaggagc tggattctcc accacaccag 13200
ggctggagag gagaaaatgt cagagaagcg ttaagggaag ctggtaagta caaataagtg 13260
aaataaatat aaacagtgaa ctgacaaaat ggcaaaaagt gaatgaaatt tgaaaatcct 13320
cagctgaaga ttattgtgta accagtggtc ctgtgagcta gtggacactt tataaaaatc 13380
tgtgatctct aaaacatatt agatacccca gtgtgaatct gtgttcagaa tacaaccatt 13440
agctaagcaa gacagagaaa tgataagtcc tgttggcaga tattttgcta ttgacttcta 13500
taacatatgc tgcaattttt actcagcagc tttggaatgg atttctatgt cctaggttga 13560
aaactaaact aaaagaaaaa cagaatagaa gttactgcac ttaatttcta aggagaaaat 13620
tttaacttta gtttgtgcat gtatatgcct gcaaaataag cattaccctt tatgttaata 13680
caaacttcac atgaatgttt aattttcaaa tatgcactga ccagtaataa tgatggcaaa 13740
attagactct atagtaggtt tatgttttat aacttaggga ttctataatg tatcttagtt 13800
gatgtcgtag ttaatagtaa ggatagtaat atcttataca gtttgcactg tcgtctgagt 13860
aaagattatc tttaaacatt tgttcctgtc agaaaaattt taaggctaaa cctattataa 13920
gatattaagc atctgatttt ggctataatg gactatctgt gagtagattt ttactcctat 13980
acaggacatc tagaaaagct gagttttaaa aatctatttg aaggcataga agacctaata 14040
aggcagctag gacttgagag ctaagacctc agaaagaaga gaaactcatt gagtgttcca 14100
aattctaggc tactttttcc ctgtagacac ttaccatttt taagtagcac atgaggagaa 14160
cccaaacaat aagcagctgc taaaatcaga gaagccaggc agattattcc acagtctgat 14220
agggctgggg aggaaaaaaa aaaattgaat tcaaggaaac caaatgattc aggacatgag 14280
aaaccatgat catggacaga aaagaggccc agaaaaatca actcaatagt ctaagcaatt 14340
ttccttccaa gtcattcact gatttataag tagcgcagac caagaggttg caaaaatcca 14400
aacacaaaga aggtgctaaa aagctgagaa gctaatcaga gctacttgca atcttattac 14460
actaggaaga taaaaattat tatagaatgt aaagcccacc aatgtggtat ggcctgaaaa 14520
acaccctaag ctttcagttg ggactgctga cggattatgc ctgaccagtt aaaggaaacc 14580
agaaatagac ccggtcaaat aaaatattga agtccatttc ccgatcaact tagtcactga 14640
ttagattaaa gtaatctgtt cttattttaa caccctagca taagtcttct ccatattctt 14700
tggagaagaa aaaatgatcc agaacctgtg tatttttcat atgtggtttc tggtattcag 14760
caaagcaaaa caaaacaaaa acaggcatac caagatatag tttccagaat atggtacaga 14820
gagaacccag acttcctgag ttgagaagac agagctcccc atgtctgggg agaccagggc 14880
aactagagtt tgtaggacag agtattggag aggagagagc tgcagagaga accccagagt 14940
tcctcacagg gtacacctca agtataaagc tgagtactga gcagcacatg catgtaagga 15000
aactacctgg gataaagaaa gaactaccca aaaggattag aagaaatagt gctcattgtt 15060
cacacagggc tgggaattgt gcctattccc accagctaga cttgaaaagc tcataattca 15120
tggagggttg ggtagtatac tttgaaagac catgccttag tagtgggaag tagccctaga 15180
ttgagcactg cactgatcct gtctaacaaa tcttttaaaa agacccaaaa ggaacaaatt 15240
gttccagtta atttgactgc atcccagaac aaagctcaaa actatttaga ggtatttgga 15300
atagcagtat tagtaatatt gcagagggaa gaatattgcc agggataaag aaaatcattt 15360
cataatgata aaggagttga ttcatcagaa agacataaca gtactaaaca tttatgcatc 15420
taataacaga acttcaaaat acataaatga gaaattgata gtgttccaag gaggaataga 15480
caaatccata actgtagtcc aaagtttcat taaccttctc tcagtaattg atgaaataac 15540
agaaaataat taggtatata aaagaagata aaaatacaat caactagctt gacctcattg 15600
atctttataa gatactctac ccagctacag caaatacata ttcctctcaa gtgtacatgg 15660
aacatttatc cagttagacc atattctgaa ccataaaaca agtctcaata aatttaaaag 15720
gattttagtt atataaggtg tgttcttgat cacaatggaa ttaattaaga aatcagtaac 15780
aaaattctca aatatttggt aactaaataa catccttcag aataactcat tagtcaaagg 15840
agaaatcaaa aggaaaatta gggccgagtg gagtgactca catttgtatt cctaacactt 15900
tgggaagttg aggcaggagg attgcttgag gccaggagtt gaagatcagc ctgggcaaca 15960
gagtgagagc ctgtctttaa aaaaaataga aaaaaaaaat tagctgggca tggtggtgtg 16020
cactcataat cccagctact tagctggagg attgctttag cctaagagtt tgaggttgca 16080
gtgagctatg atcatgccac tgcattccag cctgggcagc agagtgagac cctgtctcta 16140
aaaaaattat ttttaataaa aaataaaggg aaatgagaaa atatttgggg ctgaaagtaa 16200
aagctcatat atcaaaagca gtacttaggt ggaattttat agtattataa gcttataagg 16260
tggggcacag tggctcacgc tggtaatgcc aacactgtag gaagtcgaga caggcggatt 16320
gcttgaaatc aggagttcgg gaccagcttt gacaacatgg caaaaccctg tttctataaa 16380
aaatacagaa aattagctgg gtatggtggc acgtgcctgt agtcccagct acttgatggg 16440
ggctgaagca ggaggatcac ttgagcccag gatttcgagg ctgcagtgag ccgagatcac 16500
accactgcac tccactccag cctgggtaac aaagtgagac cctgtccccc cacacccccg 16560
caaaaaaaag cttataagaa gaaaggtctc agattagtgt cctcagcttt catcttaaga 16620
aaccaaaaca gaaaaagagc aaatgaaatt caaaataagc agaagaaaga aaataagaaa 16680
tatcaaagca gaaatcaata aactagattt tgaaaagtag agaaaatcaa tgaaagcaaa 16740
tgctgtttca ttgagaatat taataaaatt gattaacctc ttgacagaaa acaggaggag 16800
gaaaaagaga ggagttacaa tttaccaata tcggaatgag agaggtgaca tcactacaaa 16860
ttctacagat actaatggat aataaggaaa cattatagct tttctccaat aattccatca 16920
acttattaat agatgaaatg aacaaattcc ttgaaagaca caagctacca aagttcactg 16980
aagaggtagt agagaatgta aaagcccaga tctattatag acagtctcga aagttagaaa 17040
tagaagagaa cttccctagc ctgataaagg gaatctatgc aaaacgtgca cctaacatca 17100
tatttagtgg taaagcaaat agtaatataa tcgatttttt ttcttttttg agacagagtc 17160
ttgctctttc acccaggctg gagtgcaggg gcgcgatctt ggcccactgc aacctccacc 17220
tcccgggtcc aggcgatctt cctgcctcag cctcctcagt agctgggatt acaggcacat 17280
gccaccacac cctgctaatt tttgtatttt tagtagagac agggtttcac catgttggtc 17340
aggctggtct tgaactcctg acctcgtgat ccacccacct tggcctccca aagtgctggg 17400
attacaggcg taagccactg cgcccagctt tttttttttt tttttttttt tttgagatgg 17460
agtcttgctc tgtcgcccaa gctagagtgc tgtggcgtga tcttggctca ctgcaacctc 17520
caactcctgg ttcaagtaat tctcctgcct cagcctcctg agtagctggg attacaggtg 17580
cccaccacca tgcccagcta atttttttat ttttagtaga gaatgggttt caccatgttg 17640
gaccaggctg gtctcgaact cctggcctca ggtgatccgc ccaccttggg atcaccaagt 17700
gttgggatta caggcgtgag ccactgtgcc tggcctgcct agacttttaa cttatttgtg 17760
taattacttc aagtatagat tactccaatt taaacacaaa gattgtgaaa ctagatgaag 17820
aataaacata ttcaaaatga ttattaaatg ttttaattgg tgacagagtt tttcatagcc 17880
ttttatcatc tcagtgcatc atgttttatt tgtaggtagc cacagagaaa cagctacatt 17940
tataagaaca ccatgaagaa taattaaaat gttctttttt tttttttgag acagagtctt 18000
gctttgtcac ccaggctaga gtgcagtggc aagatcttgg ctcactgcaa cctctacctc 18060
ctgggttcaa gtgattctcc tgcctcagcc tccctagtag ctgagattgc aggtgtggac 18120
cactacacct ggctaatttt ttgtattttt agtagagatg gggtttcacc atgttggcca 18180
ggcttgtctt gaactcctga cctcaggtcg atccacctgc cttggcctcc caaagtgttg 18240
ggattacagg tgtgagtgac cacacctggc ctaaaacatt cttttatccc tgacttcagc 18300
tgagtttagt ttgaaatgag gctctttatt tggggtgatt gggctttgca ggagggttgg 18360
tgggtggcct ataattcccc ccaatattgt atgtaagata ttacatgttt gtatacagtt 18420
tttcaggaga gagtccgtag ctttcatcag tctctcatga ccaaaaacta tttaagaatc 18480
atggcttgaa gaatgaaaga atcgagtgcc atgttaagtg tctaatttct caataatact 18540
tccctgaaac taatttctag agaataattc aaatgacttg atctaaatat gtgtgcatga 18600
gtcatcaaag cagcctggag taacatatta aaagttatcc caagggtctg tctggttcaa 18660
actctgatga aagccctata tttcttatcc tggactgggt ttctcatagt atgattccca 18720
gatcagcagc agcatcagca tcacctagga acttgttaga aatacaaatt ctcaggccgg 18780
ccccaggcca tacctactga gttacaaatt ggagatggga ccaggaatcg gtgttttcta 18840
aggagctttc caggtgattc tggtgtgcac taaagtttga taaccactgg gttaggctat 18900
aattagaaaa tcctgttctc cgccccgctc ccaagccagg tttagaacag tttgttaagc 18960
aagtatctgc agaaagacca gtctaatgtt gacagcttct attttccatc tttatggaaa 19020
aatcgtaaag cctcaaaagc ccaaatcacc ctcacacaag tgtcttgggt tgcacagcaa 19080
caccaaacaa cagtttagag taatccaatg tccagctgaa attggaatta tagagacaca 19140
gcatgtgagt tcactcacaa aaatttttac caggaggctt tttagggatg agccccgtaa 19200
ttccaagggc cttggctctc agcctccttt gaggcatata acacagtctc ttgaacagac 19260
tgaccctcag taatgaggtt tcattaccct cttccagaca tgtggcaccc tcacaaacat 19320
cctttaacag agtgctcagt atcaccatgc ttcgtttgca aagtaactta atgaattcgc 19380
tcagcctata ttcttagtac ccagtggtag ggatctcagc tgtagcagca taaaacttga 19440
actgtccaaa accagtctct gaaaccttca agtgtttatt ctgtctactc ctgctgttgc 19500
ttgaagcttg atttgttgtt acaccttact gttttgctga tgagaaatag cacagggtac 19560
ttctcagtgg ttctcattaa aggagggcag ccaagtggaa ttcattcttg gctcttaata 19620
gttttcaaat gagaatttta ttgcatacta atgagcacta attgacattt gtgactgttt 19680
tttatggaaa taatgcatgt acaatttgca taatagtacc taagtgcttt taggtaacag 19740
tacaactctg ggaagttggt gaaggttttt gtatgatgct ttttaaaaaa gttcccaaac 19800
cccagcccct agaatagtat agaatattaa caggtctctg ggatccaaat ataaggcagt 19860
agtagtgact cagttcctgt agttgtacca gcttgtacct gagagtcaga aaatgcatca 19920
gggcaggtct ctaaaagcag gaagcgctcc cacagtagcc agggaggatg ttccagccct 19980
ctctaccttc atgtgtcaac cctcctgctt ctcctaagtc atgagtatct agacagtgct 20040
gaggattgtt ccaaggactc ctacactgta aaatgttttc taaacatcac ttggttgata 20100
tcaacaaaca tggattgatc acctactatg tgccaggcac tgtgctagat gccagagtaa 20160
gcccatgttg gcttgctgcc tgctgcatcc ctatctctta gcacaatgag gcaacagtta 20220
tccatcaatg tttattgaat taatgaacat gctgtctgcc ctcagggatc tgaggattca 20280
ttattcttac aaaatctgac gttgaataca gtataaaatt tgttgctctt catgttagaa 20340
atattaatta ttcagaactt ggaattctgt taggaaattt agagaaacaa gataatcttg 20400
gttttatgtg ccccaagttt tctgtatatc aaatgaccct tttaaatttt gtgaaaatga 20460
aagaagccaa tgtttactga agatctagta cgtatcagtt acttttgcac acatcctata 20520
catcctatga tttaagcatc aacaaaacct atgaggtgta gatagtatta tctgtgttta 20580
attgagcaag cagctaagaa ctggagaagt gactaaccta aggcatcaca gatagaaaat 20640
tgtggaactg ggacttaaat tcagcctagg ctgtgtctgt tgcactgccg cttattacat 20700
taaatgatcc taggatatgt taagcaaagc caaactctga agtattgtac tagtgatacg 20760
gctccgatga ctggaggaac actggggttc ttggtctcat gccggtttgg ataaaatgac 20820
atggacacac gtggagtggt tttagggagg gaaaagttta ataggcagga aagcaggaag 20880
gaagaagaaa acagctcccc ggtacgggga gagaagtagg gggattcaaa caaagagaaa 20940
acctcatgtg cggcagaaaa gtggctgctt atatgaggat gcaggaggag gtggtgtctg 21000
atttgcatag ggctcagggg attggtttga ccagtcatgt cattcctgca gcctgtgaaa 21060
aaactgaccc tcccacccta gctttttaat atgcaaatgc agggcgccat tatgttttac 21120
acacatgggg acatgtgggg gtggccatgt tgccaggcac atgtaggggc aagggcaaga 21180
agatggcagg aatcaccatg tttggatgga cccagtttct aatggctggc atttgcatat 21240
caaagcttgc tggcccagct cagagccggg gctttcctgc tagacaagaa acgtttctgg 21300
agctgcttta aaagaaataa aaactcccca aggacccctt ttcctctcta tctgcctaaa 21360
ataatttatt aataactcct gtaacactag gatggaggga tgaattggtc caggggtctt 21420
ggtgtgtgcc ctgcattcag ttgacctact gtttacaata cacctactgt ttacaacact 21480
attttctaga tcttgtgggg aacccaaacc aagggccagt ctggctcacc tataattcca 21540
ccaagcagcc agaaaagtat aaacgctcta cagcaaaggg ataaatcaag gtttagtaga 21600
agaaaagctt tataagtaat gtggaactaa aaggttgaat atagttttca ataatgttga 21660
gcataaatgt tctccagatt gtggaaagat cactaactgt tggctgggaa gggtaggaga 21720
ggagagagtt tgaaacacag agaataggaa ggagtggtga tgtagtccaa taactcaccc 21780
agaacccatg gacgtgaaag ctttgtttgc tctcagatcc ataactagac taaaggagtg 21840
aatcagatct gctcccctgc accccaccct gctcaccttc cacacctgcc aagggccacc 21900
cagcaattcc attctgcttg tcaaatcccc taaggaggat atgtctggaa cagccaccac 21960
tcctccccct gctcttccct ctggtatgtc aggattccct gcacaaccgt gctccagggt 22020
ccttgggatg attattcaga aaccagagaa gtatgtagaa aacttaatcg gaggcactta 22080
aaggctttaa aagggaattt taaaaaccat ctttccctct tttataaggc agtctgagta 22140
tttaagaagc aaattaattg agtccacttt acagtgttgg ggcaaaagca tgcaagttcc 22200
aacatttaca cactaacaga aaattctttt cccttccact gtgctccttt tctttcttgg 22260
gcctgctcca caaacttcta accacagtcc taaattggta ccccatgacc ctgtgtgctt 22320
cgattgccta cactggtttc agacccacgc tgtggattca aatcaaacct gcctttctcc 22380
ctgttactat gtccacccag caccctcctt gcacacacag tctttctctt ctttcctcca 22440
tgtgcagacc tttaccacag ctgtcccaaa tgtgtgaaag gccaaccata actcttcctt 22500
taaaggtcct ttagagcagt atggaaagag tgctgaactt ggaagaccta gattctcttt 22560
ctatactcat tatgtgatcc tgagcccctc acttaacctt gcagggcact tacaaaataa 22620
agagatggag ttcatgatat cttaaggtca ttttccatgt ccaacattct ctgactcttc 22680
atctttccct gactcaacat tctgttccta tatagtcaac accttcccac cttaatctca 22740
tgctcatgcc ctcttagaaa gtctttacaa ctgttgaggg tgcagtggct catgcctgta 22800
atcccagtac tttgggaggc cagagtgggc agattgcttg agctcaggag tttgggacca 22860
gcctgcataa catggtgaaa ccccgtcttt attaaaaata caaaaaaaaa aaaaaaaaag 22920
ccagatgtgg tggtgcttgc ctgtggtccc agctactcag gaggctgaaa tgggaggatc 22980
acttgaaccc aggaggcaga ggttgcagtg agctgagatc atgtcattgc attccagcct 23040
gggtgacaga gagacaccct gtctcaattt aaaaagaaaa aaaagaaaga aagcggcggg 23100
ccgcggtggc ttacacctgc aatcccagca ctttgggagg ccgaggcagg tggatcatct 23160
gaggtcaggg gttcgagacc agcctggcca gcattaagaa actctgtctc tattaaaaat 23220
acaaaaatta gctgggcatg gtggtgggca cctataattc cagctactca ggaggctgag 23280
gaaggagaat cgcttgaacc cgggaggtgg aggttgcagt gagttgagat cgtactattg 23340
cactccagcc tgggcaagaa gagtgaaact ccatctcaaa aaaaaaaaaa aaaaagaaaa 23400
tatttgcatc tgtgaactgt cttctgtgtt gaggatgttt gtggcagaag gagatagacg 23460
taggctctgt ctacgtctgc ctggtgcctc cacaaggagc agtgtatgct cagagaatag 23520
aagtgaattt tactattagt ataggtgacc catattgaaa atgtttgtaa atctgctacc 23580
agaacaacac agtcattcaa agacaattaa aaatgcattt tatacttcct gctatttata 23640
attattcatg gatctgctgc ctacagtcag gtagtaaaag gagagccaga aggaatcata 23700
gtgaacatct catacaatgc tatctttgtt gttggtttga acataagcat ttttgcgtga 23760
atttgcgtgt aggtctcttt tatttctctt attgcataac ctgaggctga aatacttcaa 23820
gtaatgtatc tatttgctca tattgggtag aaacatccct attattccaa ttttcccttc 23880
tcctgcttaa aacatatagt gaaatgaaag atgcagagat aaggaaatca gggaaaagaa 23940
aaatagtcat aggatactaa aatgagccac agatacctga aactgcatag ttgctataaa 24000
tgagccataa atttgattct gagctttcca gtggccccaa aaagataaac ataatagtat 24060
ttattccatg acataaaaat gtatttgtat ttctctgtgt tcaagaggaa gagaaatttg 24120
tactatgggt cctcatgaag gagccactaa gtcagtgttg tagaccacac attcaacgat 24180
atcgtattaa tacccatgat gatgaattca ttcattcaat aagcatttat tgagtactta 24240
ctttgtgctg tatatgtttc agtgtattgc agtaattatt ctttttgatg ctcaaattgt 24300
cctattgtgg gtcagtagga gcccgttgat tcatgtcctt ttgacattat tctgtagttt 24360
ttgatacttt ttttcctagc atgatgagat gttccaggct tatgtcgtat atttcttgtt 24420
ccgtaactca aattgaccat tttgttaatg aaacttgatt tttttcagtg aaaagtggtt 24480
ttatagaaca caatctgggc acttgaagtg tttattgtta ctgggttgtc attacttaca 24540
agactcagtt aacaaattag gaaaaagatt gatttagaaa gaaaataaat cctgagttca 24600
tattgttatt tccaatttaa agattaaagg gttttcgtat aacttatttt atatgtgtat 24660
gtcttttctc ttactttgaa atcttggttt ccaataacat gaacataatt acttccttta 24720
tcctaatagg tacgtatatg tgtatatgtc tatgtatgta tgtatgtagg tatgtatgtg 24780
tgtatgtttc tatctgtaaa acaggaaaaa tacccaccta atggagctta agatttcttt 24840
atgagtattt tttgtcctta gggtatttaa tcaaattact gttacttaaa ataatgtttc 24900
tctatgtggt tatgccatca acttcatata caattatttt atttcaattt gtcttcgatt 24960
tttaaggatg gttttcttct tctgatttaa ttttgttttt aaattatgta aaatattttc 25020
ttggtttcag agtcaaatct atgaacattg agaggtctat tttgcctctc tgtcccctcc 25080
cccttattat tttactcccc ttatagataa tgcttttatt tttccattac tttttttttt 25140
tttttttgga gacaggagtc tcgttctgtc acccaggcag gagtacggta gtgtgatctc 25200
ggctcactgt aacctccacc tcccaggttc aagcaattat cctgcctcag cctcctaagt 25260
agctgggact acagacactg accaccatgc ctggctaatt tttgtatttt tagtagagac 25320
agggtttcac tgtgttgatc aggctggtct caaactcctg acctcaagtg atccgcctgc 25380
cttggcctcc caaagtgccg ggattacagg tgtgagccac cgtgcccagc ctctattact 25440
ttttgaaaat aagccaatga cctatatgta tcctatctcc tttcttacac aaaaggtagc 25500
aggccagagt tcaagattac agtgagctgt catcatgcca ctgcacttta gcctgggcaa 25560
cagagtgaga ccttatctct aaagaaaaac aaacaataaa aaattttaaa aataatttct 25620
atgaattaaa aataatttta aacacaactg catatgaaga caacaaagga aaactctcag 25680
gaaacactga aatatgaaaa tcaagtgaga ttagagcaaa taaggatgtg tatgggaagg 25740
ttctgtagaa gacagattga ggcccaaaca gagagagctc taaatacatc atgaaggtta 25800
ccagaaatgt gagaaattcc tgaagaagag ggaagaagca aatcctctcc aaatttagtt 25860
cacttagttg ataatcatta gttgattccc agtagagtca gtcttttatc atcagtgcca 25920
ccactgttgt tctctgcatt aacaaaggag atattaatct ggaaagctgc aatcattttc 25980
actgtagaat cagcctttta ttttttaggg ttttttaatt tttttttttt aggacacctt 26040
catttaagat cacttcatat ctcctctggc ttttgcaaat gctctttggc tgatctactg 26100
tttccaccac tgtcctcaac attttttagt atattattta atttatgtat gtattggtgt 26160
ccactgatta ttgtttgcct tcccccattg gaacacagat tctataaaag tagggatctt 26220
tattttgttt accactgtat tccaggtgcc tagaacagtt cctttcacat tgttggtgct 26280
caaaaagaaa aaagttaaat gaatgaatat cagcagcaag agcattttga ggagaaagca 26340
aaggtgtaac tgtgggggtc tccattaatg tatgtatatc atcctcttat acatttgtcc 26400
catcacccgc tagccctgga actctcatta tttttttttc tggtaatgca ggctccaact 26460
caactggcaa tgagaatatg aactgaggca actgtatttg aaaaatgaaa gaatataggt 26520
gatatgggtt taaagaattc agtatttgtg tatttttcca ataagtacat gcttatgagc 26580
atagccttac aaaataacaa aaataatttt ttacatttac tcacacactt accatttcca 26640
gcactcttca ttcctttgta tagatccaaa tttgtatctg gcatcatttt acttctgcct 26700
aaagaactaa ctctaacatt tttttatagt gcatgtctct cagattttct ttgtctgaaa 26760
attactttat tttaactcca tttctgaaat acattttcag tgggtattgt attctgggct 26820
gacttttttt ttttttccca gtgcttgaga gatgccattc cattctcttg tggctttcat 26880
tatttttgat gaaaaatcag ttgtaagtct tactcttgtt cctctgtaca taatctgact 26940
gctgcttcta aaattttatc tttattgctg gtttttagca atttctgtgc cttgttttgt 27000
ttttgttatt tagtgtttgt tctgcttggg attggttgag cttggatctg taggtttata 27060
cttttcatca aatacgaaaa attttggtca ttatttttca aatatttttt ctactcctcc 27120
ctcctcactt tttccccctc aaacagcagt tacatgtatg tcagacaact tgctattatt 27180
ctataagtca ttgagacaat gttcattctt ttttattttt aatttttgtg ggtaaatagg 27240
tgaatatatt taggggttca tgagatgttt tgatataggc atgcaatgta aaataagcac 27300
atcatggaga atggggtatc tattccctta agcatttatt ctttgaatta aaaacaatcc 27360
acttacactc ttatcacttc tcagcctttt gggataagat catgtgtaaa aacaatgtac 27420
ttacactttt cattttaaaa tgtacaatta agttattatt gactatagtc accctgttgt 27480
actatcaaat agtaagtctt actcattcta actaattttt tataaacttt aactataccc 27540
acttctcctc ccacctccca ctccctttcc aacctatggt aaccatcctt ctatactctg 27600
ttcatgagtt cacttgtttt gatttttaga tcccacaaat aaataagaag atgtgatgtt 27660
tgtctttctg tgcttggctt atttcactta acgtaatgat ctccagtgcc atccatgttg 27720
ttgctaatta ctggacctaa ttcttataca tggatgaata gtacatcatt gtgtagatgt 27780
accacatttt ctttattcat tcatctgttg atggagactt agattgcttc caaatcttag 27840
ctatagtaag caatgctgca acaaacagga gtgcagacat ctctttaata tactgctttt 27900
ctttcttttg ggtatatatc cagcgatggg attgccagat catacagtag ctcaattttt 27960
agttttttga ggaacctcca aactgttctc cataatggtt gcactaatgt acattcccac 28020
caacagtgta caagggtccc tttttctcca catcctcacc agcatttgtt attgcctgtc 28080
ttttggatat aagccatttt aactggggtg agaagatatt ttagttttca tctgcatttc 28140
tctgatgata aatgacattg agcatctttt catatacctg tttgccattt gtctgtcttt 28200
gttggaaaaa tttctgttag ctcttttgcc cattttttta atcggattat taaatttttt 28260
cctatagagt tgtttgagct ccttatatag tctggtgatt aatcctttgt cagatgggta 28320
gttggcaaat attttctgtc attctgtgag ttgtctcttg actttgttga ttgtatcctt 28380
tgatgtacag aggctttgta acttgatgtg atcctatttt tccatttttg ctttggtcgc 28440
ctgtgcttgt ggcatattgc tcaagaaatg tttgcccaga ccaatgtcta gagactttct 28500
gcaatgtttt cctgtagtat tttcatagtt tgaggtctta gatttaagtc tttaatccat 28560
tttcatttga tttttgtata tggtgagaga tgggtgtcca gtttcattct tatgcatgtg 28620
gatatccagt tttcccagta ccatttattg aagagaccct ctctttccca gtgtatgttc 28680
ttggcacctt tgccaaaaat gagttcactg tagtttctgg gttctctctt ctgttctatt 28740
ggtctgagtc tgtttttatg ccagtactat tctgttttag ttacaatcat tctgtagcat 28800
aatttgaagt caggtaatgt gattcctcca gttttgttct tttcactcag gataccttta 28860
actattctgg gtcttttgtg gttccacata aattttagga ttgtattttc tatttctgtg 28920
aagaatgtca ctggtatttt gatagggatt gcattgaatc tgtagattgc tttgggtagt 28980
atggacattt taacaacatt gattcttcta atccatgtat atgggatatt tttccatttt 29040
tggtgtcttc ttcaattttt ataatctgtg ttttatagtt ttcattatac agatctttca 29100
cttctttggt caggttaatt cctagatatt taattttatg tgtggctatt ataaatagga 29160
ttacattttt atttcttttt cacatagttc actgttggca tatagaaatg ctactgattt 29220
tttataaact tttatgttat gttcaggtgt ataggtacag gtttgttata taggtaaact 29280
catgtcatgg ggtttgtcgt acagattatt tcatcaccca ggtactaagc tagtacccat 29340
tagttatttt ttctgatcct ctccctcttc ccactcttca ccctcagtag gccccagtgt 29400
ctgttgttcc cctctgtgtg tccatgtgtt ctaatcattt agatcccact tgtaagtgag 29460
aacatgcagt atttggtttt ctgttcctgt gttacttttc taaggataat ggcctccatc 29520
tccatccatg ttcctgcaaa ggatataatc tcattctttt tatggctgca tagtattcca 29580
tgatgtatat gtaccacatt ttcttttttt ttcccttcaa cttttatttt aagttcaaga 29640
gtacatgtat gtacaagatg tgcaagtttg ttacataggt aaatgtgtgc catggtagtt 29700
tactgcacag atcatcacat cgcctaggta ttaaggccag catccattag ctattcttcc 29760
tgatgctctc cctccctcac cacaccccct ccgacaagcc ccagtgtatg ttgttgcccc 29820
ctcacatgtg tccatatgtt ctcatcattc agctcccact tataagtgag aacatgtagt 29880
gtttgggttt ctgttcctgc attagtttgc tgaggataat ggcttccagc tccattcatg 29940
tccctgcaag gaacatgatc tcattccttt ttatggctgc atagtattcc atggtgtata 30000
tgtaacacat tttctttatc tagtatatca ttgatgagca tttaggttga ttccatgtct 30060
ttgctattgt taatagtgct gcagtgaaca tatgtgtgca tgtatctttg taacagaatg 30120
atttatattc ctttggatat agacccagta atgggattgc tgggtcaaat ggtatttctg 30180
cttctaggtc tttgaggaat tgccacacta tcttccacaa tgattgaact aattcatact 30240
cacaccaata attccttttt ctccacaaca ttggcagctt ctgttgtttt ttttgacttt 30300
ttaataatag ccattctgac tggcatgaga tggtatctca ttgtggtttt gatttgcatt 30360
tctctaatga tcagtgatgt tgagcttttt ttttcatatg tttgttggcc agatgtatat 30420
cttcttttga gaagtgtctg ttcatgtcct ttgcccactt tttaatggtg ttgtttgttt 30480
ttcttgtaaa ttggcttaag ttccttgtag actctggtta ttaaaccttt gtcagataga 30540
tagattgcag aaatttttct cccattcttt aggttgtctg tttgctctaa taatagtttc 30600
ttttgctgtg cacaagctct taagtttaat tagattccat ttgtcatttt tgctttcatt 30660
gcaatcactt tcggcatttt tgtcatgaaa tcttttcctg tgcttatgtc ctgaatggtt 30720
ttgcctagac tttcttctag agtttttttt tatagttttg ggttttacat ttaagtcttt 30780
aatccatctc cagttaattt ttgtatgtgg tgtaaggaag gggtccagta ttaattttct 30840
gcatttggct agccagttcc cctagcgcca tttgttaaat agggaatcct ttccctattg 30900
cttgtttttg tcaagcttgt caacagtcag atggtggtag gtatgtggtc tgatttctga 30960
gctattttgt ttcattggtt tatgtgtctg cttctctaca actaccatgc tatttgggtt 31020
actgtagcct tgtactatag tttgaagttg ggtagtgtga tgcctcaagc tttgttcttt 31080
ttgcttaata ttgccttggc tattagggct cttttttggt tccatatgaa ttttaaaatg 31140
attttcttct aattctgtga agaatgtcaa tggtaattta atgggaatag cattgaatct 31200
ataaattact ttgggcaata tggccatttt catgatattg attcttccta tccatgagga 31260
tgaaatgttt ttccgtttgt ttgtgtcttc tctgatttct ttgagcagtg gtttgtagtt 31320
ctccttgaag aggtccttca cttcccttat tagctgtatt cctaggtatt ttattctttt 31380
tgtagcaatt acgaatggga gttcattcac aatttggctc tctgcttgcc tgttgttggt 31440
gtataggaat gctagcaatt tttgcacatt gatgtttata tccttagtct ttgctgaagt 31500
tgcttatcag cttaagaagc ttttgggctg agacaatggg gttttctaga tataggatcg 31560
tgtcatctgc aaacaaagat aatttgactt cttctcttcc tatttgaata ccatttattt 31620
ctttctcttg cctgattgcc ctggccagaa cttctaatac tatgttggat agaaatagtg 31680
agatagggca tccttgtctt gtgccagttt tcaagggaat gcttccaact tttgcccatt 31740
cagtatgata ctggctgtgg gactgtcata gatggctctt attattttga agtatgttcc 31800
ttcaatacct agtttattga gagcttttaa catgaaggga tgttgaattt tatcgaaggc 31860
cttttctggg cctattgaga taatcatgtg gtttttgtct tttattctgt ttatgtgatg 31920
aatcacattt attgatttgc atatgttgaa ccaaacttga atctcaggga tgaagccaac 31980
ttgatcgtag tggatacgct ttttgatgtg ctgctggatt tggtttgcca gtattttatt 32040
gaggattttt gcctcaatgt tcatcaagga tattggcctg aaattttctt tttttgttgt 32100
tgtatctctg ccaggtttgg tatgaggatg atactggcct caagaatgag ttagggagaa 32160
gtccttcctt ttcaattttt tggaaaagtt tcagtagaaa tggtaccagc ttttctttgt 32220
accgctggta gaattcagct gtgaatctgt ctgatcttgg gctttttttg gttgttaggc 32280
tatttgttac tgcctcaatt tcagaacgtg tcattggtgt attcagggat tcaatttctt 32340
tctgcttcag tcttgagaag gtgtatgtgt ccaggaattt atccatttct tctagattct 32400
ctagtttatg tgcatacagg tgtgtgtagt attctctgat ggttgtttgt atttctgtgg 32460
gatcagtgat gatatcccac ttaacatttc tgattgtgtc tgtttgattc ttctctcttt 32520
tgttctttat tagtctagtt agttgcctat ctttttatta attttaaata aaacagctcc 32580
tggattcatt gatttttttg aaaggttttt tgtgtctata ttttcatttc aactctgatc 32640
tgatcttggt tatgtcttgt cttcttctag ctttgaaatt tgtttgcttt tggttctgtc 32700
attcttttag ttgtgatatt aggttgttaa cttgagatct ttctagcttt ttgatgtggg 32760
catttagtgc tataaatttt cctcttaaca ctgcttcagc tgcaccccag agattctggt 32820
atgttgtctc tttgttctca ttagtttcaa ggaatttctt gatttctgcc ttaattttgt 32880
tatttaccca ggagtcattc aggagcaggt tgttcaattt ccatgtagtt gtgtggtttt 32940
gagtgaattt cttaatcttg agttctaatt tgattgtgct gtggtcagaa agactgttat 33000
gatttcaata cttttgcctt tgctgaaaaa gtgccatgtg gtgatgagaa gaatgtatat 33060
tctgttgttt ttgggtggag agttctgtag atatctatca ggtcctcttg atccagagct 33120
tagttcaggt cctgaatatc tttgttaatt ttctgtctca gtgatatgtc taatattttc 33180
agtggagtgt caaagtattt cactattatt gtgtgggagt ctaagtctct ttgtaggtct 33240
ctaagaactt gctttatgaa tctgggtgct cctgtattgg gtgcatatat atttaggata 33300
gttagctctg cttgttgaat tgaacgcttt accattatgg aatgcccttc tttgtctttt 33360
ttttatcttt gttggtgtaa agtgtgtttt gtcagaaact aggactgcaa cccttgcttt 33420
tttctgtttt ccatttgctt cataaatttt tctccattcc cttattttga gcctatgtgt 33480
gtctttgcac ttgaggtggg tgtcttgaag acagcatact gatggccctt ggctgtttat 33540
ccagcttgcc attctgtgac ttttaattgg gggcatttag cccatttata tttaaggtta 33600
gtattgttat gtatgaattt gatcctgtca tcatgatgct agctggttat tttgctgact 33660
tgtttttgtg gttgcttcat agtgtcactg gtctgtgtac tttagtatgt ttttgtagta 33720
gctggtaaca gtttttcctt tccatattta gtgcttcctt caggagtgct tgcagggcag 33780
cctggttgtg acaaattccc tcagcatttg cttgtctgaa aaggatctta tttctccttc 33840
acttatgaag cttagtttgg cccgatgtga aattctggat tggaaatatt tttctttaag 33900
aatgttgaat attggtttcc agtctcttct ggcttgtaga gtttctgctg aggagtccac 33960
tgttttctgt tgggcttccc tttgtaggtg acctggactt tctctctggc tacccttagc 34020
attttttttt tcattttcac cttggagaat ctgatgatta tgtatcttgg agttgatctt 34080
cttgtggagt atcttactgg ggttctcggc atttcctgaa tttgaacttt ggcccatctt 34140
gctagcttgg agaagttttc ctgtatgcta tcctgatgca tgttttccaa ctcagttcca 34200
ttctgcccct ctctttcagg taccccagtc aagtcatagg tttggtctct ttacataatc 34260
tcatatttct ctgaggtttt gttcattcct tctcttttta tttgtttctg tattcttgtc 34320
tgcctgtcta tatgcagaaa gatagtgttc aagctctgaa attctttcca ctgcttggtc 34380
catcctatgg atacttgtga ttgcattgtg aagttcttgt gtattacaag aactttattt 34440
ttttatcttt atccagtcta ccattgatgg gcatttaggt tgattctatg tctttgttat 34500
tgtgaataat gctgtaatga acatactaga atgattcatg tttatttggg taaatgtgtg 34560
ttgatttcgt atcctgcagt tttattgaat ttatcagttc taatcatttt tcttgtggag 34620
tctttaggtt tttccaaata taagatcata ttgtctgcaa acaatgatca tttgagttat 34680
tccttttcaa tttggatgct ttttatatct ttctcttatc taattgctct agctaggact 34740
tccagtagta tgttgaataa cagtgatggc agtgggcatc cttgttgtgt tccagatttt 34800
agaggaaagg ctttgtcctt cccctatgcc ccaggtaggt ccaggagtca aggactagag 34860
tccaaaacct tagaagtcta cctggtattc tattatactg tggctgagct ggccctcaga 34920
ccacaagaca cagtccttcc cactcttctc tcccctttcc aaaggcagag gaactgcctt 34980
tagtagagac agggtttcgc catgttggcc actgccaacc cagcccatga ggaggactgc 35040
cagactactg ctgatgttcc cttaaggccc aagttctctt aaatcagctt gtcctgaatg 35100
ttacctagcc tgagactcac ccttcaggac agtgggctcc cctctggccc agggaaggtc 35160
cagaaatgct gcccaagggt caagtcctgt aatcagggac tccaagagcc ctcttggtat 35220
tctaaccccc tgtatctgtg gtggtaccta aggtgcaaga caaagtccct tttacatttc 35280
cttctgcttt tatcaagcag aagttttgtc ctgcagccac cacagctggt aatgtactga 35340
gttctacctg aagccaggaa gtctcagagg ctcacccaag gccctcaaca tagtccctgg 35400
ttattgctgc tggttattca gaaccaaggg ctcttcactt agcaggtgat aaatgccggc 35460
agggctgggt cctttccttc aatgcagtgg gttccctctg gcccagggtg tgtctagtaa 35520
tgtcacctgg tttctagggc ctagaatgga ggcctcatga ctctgaccag tgccctatcc 35580
tgctgtggct gcgctggtat cctagacgca agacaatggt ctccccactt ctccctctcc 35640
tattctcaag tggaaggaag gggtctcttt tggagctgta agctgtgtag cctggggtaa 35700
ggggaggggt gatgccaata ctctcttggc tgccccagct ggtgtctcag taggttgcat 35760
gcactcccag tctgctgtct ctgggcctag ttcagcacca ggactcacct aagagttgca 35820
gtccttatgg cctagactgc ttttgaagtt tacttggaga caaagagcac tgtggccttc 35880
actggtgagg tttacaggca ctcaagttta gaccactggg attggtgatt cttctctggc 35940
tagggctgtt ttaaatcctc cctccgtttg cacatttcag ctgagtttga tctagtttgc 36000
ctttctgctc tgatttctgg ttcttatgaa ggtgtttttt tctgtgtaga cagctgttaa 36060
cttggtgtcc ttgcagaggg aatgatcagt ggagccttct atttcgccat cttgatccgc 36120
cgccatatat cattcttatc aatcattttc tgtttatgca cctgaaaata cactggtata 36180
caaaattaag atccttactt tcacagaatt tgtgttctaa tgggggaagt caataatcgg 36240
tggacaccaa tacatatata aattaaataa cacattaaaa ggtgttgagg acatgctggg 36300
catggtggct catacttgta atcccagcac tttggggggc cgaggcgggt gcatcacttg 36360
agatcaggag tttgagacaa gcctggccaa catggtgaaa ccctgtctct actaaaaata 36420
caaaaattag ctgggtatgg tggcaggtgc ctgtaattcc agctactagg gaggctgagg 36480
caggggaatc gcttgaagct gggaggcaga ggttgcagtg agctgagatc ctgccactac 36540
actccagcct ggacaacaga gtgagactct gtctcaaaaa aaaaaaataa ataaaaataa 36600
aagctgttga ggacaatgga ggaaaaggca gatcagagaa agaacattta caaaagccag 36660
agggagtgtg aagcaatttt aaatgaggtc agatttttgg ataatttcta ttgctatgtt 36720
tttaagttaa ccaatgtttc tttttgcaat gtctgatctg ttacattttt atttcagata 36780
ttatattgtt atctctagaa gttctattta gatctccttt ttatctttca attctctcct 36840
cattttgttc atattttgct ttatatccta gagcatattt ataatagttg ttttaaggtt 36900
cttgtgtgat agttatatca tttctgttat ttctgtgtct gatattattt atctattttt 36960
taaaacttta tgggtatagg tcatattttt tcatttcttt gaatgcctgg tgattatttt 37020
gaattttaca ttgttgagca ctggatgttg ttatattcct tttaagagca ttgagttgtg 37080
ttctggaatg cagttgagtt tttacagatc actttgatcc atttgagact ttcctttagg 37140
gtatatccag agtaacatct agtttagagt taatttgttt ttactactaa gatgtggctt 37200
ttctgaggat tttatccaat gtcctgtgta ttttggggtc tctccacact ggctgatgga 37260
aacacagggt agtctcagcc ctgtgtgagc tccaggaatt actcagctat tgcctatcag 37320
tgtttttttc ttcaactcca agtagtttct tccagctcat atccaaatca tacttaggag 37380
aagactgggg gggatcctct gcagatttcc aaagtgctct ccccactctc tgtatctccc 37440
tcttcttcat tactctgtcc cacaaattct aaccacctca acatccttaa attccaatcc 37500
attccccctt acctcaggta gaattctagg ttctgattgg ttttccctcc acgtgctgtg 37560
acctggaaat gacctccagg cagtatctct taggaagccc agttgtgtgg catctgttgt 37620
acaatgcctg aaaatgattc tttcatgtgt tttgtctggt tttcaacttg ttcacagaaa 37680
aaagcaattt gcacagcagt taattcttca cagacagaag cagaagttct accaactgca 37740
aaacaaccaa aacaacttgt taaaagacag tatttgtatg actggtcata aattacgtat 37800
agaagaatag agattttgtg agaaagatat gggcctgtac agaggggtga acttgcaaat 37860
gaccatcttg cttggggata gtgtctgttt tcctgatcct aatcactggg aaggattctg 37920
taatctctgt caaataaatt gcaaacacta ccacacatgg ccttgggtct actactgtct 37980
atgacataaa cagtttctcc ctagagactt agttgtgagg gtacaggggg aaggtagctt 38040
ttggaggggc ctggaagacc cttccctttg tgccttcgat tctgtatata tcttgtggtc 38100
agaagtctta ccattaccct ctctgataac tccccaccca ctttcccaat cactaaacac 38160
tttttgaaac cattcaactc tttcctttca atgattgagc ccttcattgt ttcatcagct 38220
cctcttgtgt gaatctctct gaatgtgtgc caagtttgca gtttaatgcc tgtcccatgt 38280
aggagcccaa tatcacggta tataaagttt ctacactgga tatccatgga ctgaagaggg 38340
gcctagcatt cagggttcca agccagtgag tttagcttat ccaagggtac ctctagaatg 38400
tgctcagaaa tttattccaa gtcagagttg catcccccag gactttaggc tcagatggac 38460
aaccccatca tatttacaga atccctcaaa gataatttaa gtttaagatt gtcagcccac 38520
ctggggtgca cagtgttgac cagggtttct taaccttagc actgttgaca tttggggcca 38580
gataattctt tgttgttcag accatcctgt gaattatagt atgtttagca gcatccttgg 38640
catctaccta ctagatgtga atagcatcct tctcttaatt ttgacaacca cagatgtctc 38700
cagaattgcc aaatgtcccc taaaggtgca aaattgcata gttgagaact actggtaaag 38760
aggcactatg gcatgccaag ctctagggag cccacagaag tgcacctctg ggaactaaag 38820
ctgaagaaac ccaagaggcc ccttggtatc ttcttggaag aagttagtcc agagtgtctg 38880
caccatgtgg agtgtatact gggatgacat tgaccttgga atgtaaactc ctgggattct 38940
tgcctctgca gatttggagc agggttttct tcttctctgc ttttcagttt acttatttga 39000
aaatgaggaa tggtgtttac atcacaaaac actgtagtga ggacaaaatg aggttttatg 39060
tatatataca cccatacata tacatataca cttcttccaa atgatataat aatatataaa 39120
cattgaatga ataatggttc aaatataagt gtacttattt gccactatga ttaaaagggc 39180
aatataggaa aaatacattt tcttctaatc catcatgttg taataatcct ccctgtggtt 39240
gcagtatggt tctgtgctag aaggcacaat aggaaatctc taactttaaa aaaaaagaaa 39300
agaaaaaata tctttctagc aattaaaatc tcaactaaat tagaatgcaa ataggttttt 39360
atatttgctt cttaattttg cattcaataa tctgactaga atatgcaata atttaaatgc 39420
cttgatggga gatagtggct tttagttctc ttgggatttc attgtaataa acctggtaaa 39480
taattcagga acatatgaga ggccaatgaa tggtcagcac ctggtgctat attatttgtg 39540
cctaagcaca cagactccaa agatggcact ctccacctgt cactgttgtt ctggcttaaa 39600
catgggccct gtgttcagtg gctattgaga taatagtaat ggatattttt gccttgtcca 39660
attttcctcc acaatcaaag aaaactgtgc taagctgttt aaaaaataca aagcagaagt 39720
ggcagcctct tttagattac cactggtaaa atttcaaatc tattttctct attaagggat 39780
tgattgtttt aaagaattag ggatatggct atcttttcta ctggtgctaa tttgagcctt 39840
tttgcctttc tgtctttgtt ccacaaggct gagcttctct ttagatcaca ttattcatat 39900
tgcaaggatc ttctgagaga aataacacca tcctctggcc agccactcac tctgcaggag 39960
ttcctagagc tccccagttt ctttccctat tgcctgagta gtctatctca cgcctgttag 40020
tctcacagtt taaatacaaa cacacaaaga ctcttgcagg cagcttgggt acctttcttt 40080
gaccccagcc gactggacat agagaacaag agctagagag aacaagagct agagtgaccg 40140
acagatcatg tgtggagaca gcatggggca cctgagccca gcaccatcca ggatcagaca 40200
gaacttaagc catgagctgc ctagaaagat cttgggaggg cactgggttt cccagtatgg 40260
aaaaaagaaa aatgtggctc acaagtctaa gctaaggtct ttacagtact gggccataaa 40320
caggatctga aaagaaactg cagaaaatgt tagatatgct ttatctttgt tttaaaaata 40380
ttatttacta taatggctta aaatatgttg atttaaatat atgatatttg atacctttgt 40440
aatatatata ataaagtgta taataaaata taactatata attaaaatag atgatatttt 40500
aaaacctctc taataaacca tttacgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 40560
tgtgtgtgtg tatacatgcc tttgtttaac aggtttaatt gctttccttt cttcaggaac 40620
cagagtgagg gtactcgaac agtgactgcc atctggtggt taaccagaat catcaccttg 40680
tgtagcctga tggttactaa gatgtccact cttgactcac atggcatgca ctcgcagcag 40740
gggaccagtt gaaggatgtc tgactttgga gggtcaccag ttgaaggatg tctgatgaag 40800
gagcctagcg aaataaccct ttgcttctac ctgaatgggt tgttcactct ggattctgag 40860
cctgcagcca gctccaaaat ggggcctctg aagaaaagat ttgagttgct cttgtgtctt 40920
agtcaaagat ctacatccct accagtgggt aaccaagact gtgaataagc acacaccaac 40980
aggggcatgt ggtgacatgg agcctgaaat aaactgctct gaattgtgtg acagttttcc 41040
tggccaggag ctggatcgga gaccccttca tgatctctgc aagacaacaa ttgtaagtga 41100
gcagccacag gatgccaggg ctgctcagat gtatgtggtg gtggtggtgt tggggaggag 41160
gaggtggagg gaaaggggga tgaggaaggg gaggagtggg aggagaaact gctcatgcag 41220
gatacatatt tcccagcact tggtgacgat ggggcagttt gtttttgacc tatagaagat 41280
ccttcattcc taacagctcc tccttattct gtcctcagac atcttcccac cacagcagta 41340
agaccatctc ttcattatct cctgtcctct tgggtattgt ttggactttt ctcagctgtg 41400
gacttctgct gatacttttc tttcttgcct ttacaattca ctgcaggaag aacaggtaag 41460
cagcccagtt tctcatcaca catagctcaa tcatgaaatc ccaaatgtta gtatcttttg 41520
gcagcacaag ccactatctg gtctcccact acaggattaa accacatgag acattccctc 41580
tgaaatagtc tacctgttga gaaggggaaa gatctaggtc ggtattgtgc taactactgc 41640
aagggtatcc aaagaagaga atgaagagtc tctctctata atggaggtac aatccttctg 41700
agaagatgag gtatctgtat ttaaaatgaa gaccatgtag aggattccaa aacaacacaa 41760
aaacttgagg acagcacagc agaaccagtc tgggtgagtt agggtttctg caaaagcagt 41820
gaagcactgc tacctggcta tttgctagat aattctggct gactagaaag tcatcagctt 41880
atcagggtaa gtatggctcc caggattcgc aaaagaagca aaatggtgac ttttttctga 41940
agggacttat agcaccttgc cttggatgca atttcatcct tcctcagggc ccatcccatc 42000
tctcccaccc ccacactgta ccctcatcct accacagccg tcccagggtg cctcatgaga 42060
agccctgctc cagccctctc cttagcccac agctgacttc tagatggagc ccacaatcag 42120
aaattaacaa cttcctcaaa ccagccaaac tcgtccagcc ccactccagc cttaccctgt 42180
gtggtgacca agcatgtcgt gctccattgc ctgtggattt gacactcaga tgagaattgg 42240
tcagttgcat tttgggatgc tgttttgcca tgttaggcat ggaggacgtg gaattgttaa 42300
gcagcagtga ttggttgttg ggtcagcctc agcatggtgg tgatacgtgg cactccaact 42360
agagtatacc ccagagactg cctcagccac ttttcattct gttcctcaag cacactacgc 42420
tgactcccat ctcaaggctt ttgtacttac tgttcctgta ctgttccctc tgcctggaag 42480
tcctcctcag atattcccat gactagttcc ttctcatctt ataggtcttg gctccagtgt 42540
cacctcttca gagacacctt ccctgatcat cctatctaaa gtagtatccc tacccatgat 42600
caccccctca tctcattcca tatcctatca gcctgtttta tgttccttat agcaagcata 42660
gtctgctatt accatatttg ttgatttacc tgttgattgt ctgtatcccc taccagaatg 42720
gaattctgtg aacacaggga ctttgcctgt cctcttgtgc ccaccactgt gtctccagca 42780
tttagaacag actctgggat ataataggtg ctcagtaaat atgcatccag tgatcctggg 42840
aggaaagaga tttaaatccc aacggtggct gctgccaaca aagtgactgg gaaaatcatg 42900
catttcaagg ttagagaact atggagtaca gtcttttcag ctgtaacatg tttctataat 42960
gcaaagtaat actcaattgg tattacccag ttggtaataa gaaaattatg tcattgattc 43020
atatgttact tttcccccag caaatcaata atttaaacat tcaggggcaa gctttctcac 43080
agctagtaaa ggaagcttta agcttggcag ttccttccct tggtgcaagt agtgtctggc 43140
ttaatggctt aagaacttgt gtcttcccta caagatgagg ctgtaggagt agatgaagaa 43200
gtggagaaga catttgcctt atgtttaaaa acttcagttg attgttaaag aaagcacaga 43260
tccagagcag atttttaatt ttttgacaat gttatctact ggagatgaat gcccctgagg 43320
acctgtgtct tgagatttaa gactgtagaa gttgactttg atcctgggta caaatgctag 43380
tggacattta ctgggtggta gtgttttagt tggaataatt aatattttat taatactctt 43440
gttacaaagt taactgtttt gagtgttatg accccatcct attttcccca cagtctatta 43500
tttttacata taattttgca gaatacaagg tttatcaagt atttatatat cctgttaaaa 43560
caggaacacc tgtaaacagc attatactag aaacccttat atttctttca ctctattaaa 43620
tattttgctg cctgttttgt ttgcagtggg agcatgactt ggcataaaga ataaaatatt 43680
aagaggtatt gtgaataaaa acacatttta caattaagtg gcttacaagg tcagacaagg 43740
aaagataaaa taacccagtt tcaaaagtgt tttattgaac aatacatttg ttaaaagatg 43800
cagcatcaca atcagatgct ttatttcgtt acaattctgt ggtctctaaa tttgggactg 43860
tgtgtgtgag tattcatgtg tgtgtatatg caagaaagga gaggaagaaa aatattttaa 43920
cacaataaaa ataatacaaa aatgtttaaa tccagttgca gatattgaat ttttataaaa 43980
atttcaaaaa ccagtaaaga taaagaaaac ttgaacacta tcaaccaact tgacccaatt 44040
gacatttata ttacctttca cccaacaaca gcagaataca tattcttttg aagtacacat 44100
ggaacattta ccaagatata tcatattctg ggccatagaa aaagtctcat taaatttaaa 44160
agggttcaag ccgggtgcag tggctcatgc ctgtgatccc agcactttgg gaagctgagg 44220
cggatagatc accagaggtc agcagtttga gaccagcctg gccaacatgg tgaaaaccca 44280
tctctactaa aaatacaaaa attagatggg tgtggtggca tgcacctgta gtcccagcta 44340
cttgggaggc tgaggcagga gaacccggga ggcagaggtt gcagtgagct gagatcatgc 44400
cactgcactc cagcctgggt aacagagcaa gactctgtct caaaaaaaaa aaaaattaaa 44460
ggattcaagt catataaact atgttttctg acaatgaaat taaaatggaa atcaataaca 44520
gaaagatctc tggaaaatcc tgaaatattt agaaactaca tagaacactt taatccatgg 44580
tcaaaaaaga aatcaaaagg aaaactagaa aatattgacc agaattaaaa tgaaaataca 44640
acctagattt gttggatgcc actaaagcag tattaggggg aaatctagag aactaaaccc 44700
catattagaa aagaagaaat gtctcaaatc catgacctca tcttccacct tacaaacaga 44760
aaaaaagagc aaatgagacc caaagtaagt agaagaaagg aaataataaa gatcaggtta 44820
gaaaataaaa taggaaacag aaaacaatag gaaaaaaaag tcagtaaagc caaaagctat 44880
gaagataagt aaaactgatc aacctctagc caaagtgatc agaaaaaaaa gaaataagat 44940
acaattaccc aaataaggaa tgggagaggt gacatcacta tagattctgt agatatgacg 45000
gataaggtaa tgttgtaaac aactatggta gatagcctct aagatgttct tcgatgattc 45060
ccacctcctt gtagtcacac tcctatgaag tcctctctcc ttgagtatga ggtgaactta 45120
ctaacttgct ttttagtgag atgtcgcttt tggcattagt tcacaaaaac tgtggcttcc 45180
accttagagc tctctcattg tcccactaac tcccactctg tgggaggcca gctgttgtgt 45240
tataagctgt cctgtaaaga ggcccccatt ggcaaggaac tgatgtttcc agcctgcagc 45300
cagcaagtac ctggggcttg ctaacagcca tgtcagtgaa ctttgaaaca ggtgacacct 45360
tgactgtatt gttgtgacac cttgactgta ttcttatgtg aaaacctgag ccacaggcac 45420
ccaactaagc tgtgacttag aaatattacc agttcaactt caaactcttc taaaaaaact 45480
gaaaataaag aagtaattcc caactcattc tatgagggca gtattaccct gatttcaaaa 45540
ttgaatagga aaaagaagaa ggagaaggag aagaaggaga aggagaagga agaggaggag 45600
gagaaggaga aggaggagga ggaggaggag gagaagaagg agaaggagaa gaagaagaag 45660
aagaggaaga ggaagaggag gaagaagaag aagaagaagg gaggaggaaa gctataggct 45720
aatatgtcct ataaacatag attcaaaatt ttaaacaaaa ttttaacaaa ttgagtatca 45780
ccaaatgtta aaaagagaat acatcattgt gacaacgtga ggtttatccc tggaatgtaa 45840
gctttgttta atatctaaag attgatcaat aactcatgac atttaccaac taaaaaagaa 45900
aactatatga tcatctcagt agatacagaa aaatttttga caaacttcaa catcaatttc 45960
tgataaagtc tcaacaaaca gcatagaaca gaacttcctc cccattgcgc agcacagctg 46020
ctgtggcaga ttgtggccag actgcttctt taagtgggac cccgatccat cccccctcac 46080
tgggcaggac ctccttgtga gaatttcagc aactccagcc agggttttat ggacagaact 46140
ctgatctctc tgggacagag cccctcaggg gaagggtggc cacagtctct gtggttcagc 46200
caacttagcc tttcctgcct gctggctctg gagagtctgg gcagtctgga caaaagggga 46260
tccccccagt gcagtgcacc cagtccccca aggggcagcc agactgcttc ttgaggcagg 46320
tccctgatcc cattcctcct gactgggtga gaactcccaa agggatcccc agacacctct 46380
tacaggagtg tttgggccag cgtcagtttg gagcaggcag ccatctttgc tgttttgcac 46440
cctttgctgg tgatagtgat acctccaggt gcagaaggga cccaggtgat tagggtctgg 46500
ggtggaccac tagcaaacca cagcagccct gcagaagagg agcctgactg ttaaaagaaa 46560
aacaaagcag caacaacaac ataaacaaaa aagatcccca aaaaaaccca ttgaaaggtc 46620
agcaacctca aagactgaag gtagataagc ccacaaagat aagaaagaat caatgcaaaa 46680
atgctgaaaa ctcaaaaagc cagagtgcct cttctccaaa tgattgtaat acctctccag 46740
caagggcaca gaactgggct gagactgaga tggctgaatt gacagaagta gccttcagaa 46800
tgagggtaat aacgaacttt gctgagctaa aggaacatgt tctaacccaa tgcaaagaag 46860
ctaagaatca tgataaaaca ttacaggagc tgataaccag aatagccagt ttagagagga 46920
acataaaaca cctaatggag ctgagaatca caacgtgaga acgtcacaat ccaatcacta 46980
gtgtctatag ctgagtagac caagcagcag aaagaatctc agagcttgaa aactgtcttt 47040
ctgaaataag acaggcagac aagaatagag aaaaaagaat gaaaacaaac aaaacctcca 47100
agaaatatgg gattacgtaa aaagaccaaa cctacaactg attggagtac ctgaaagaga 47160
tggggagaat ggaaccaaat tggaaaacat acttcataat gtcatccagg agaacctcgc 47220
caatctagca agacaggcca acattcaaat tcaggaaatg tggagaaccc cagtaagata 47280
ctccacaaga agatcaaccc caaaacacat aatcatcaga ttacccaagg tcaaaatgaa 47340
agaaaaaatg ttaagggcag ccagagagaa aggccaggtc atctacaaag ggaagcccat 47400
cagactaaca gtggacctct cagcagaaat cctagaagcc aaagaaactg gaggccaata 47460
ttcaacaatt tttttatttt ttgttttttt gagactgagt ctcgctctgt cacccaggct 47520
ggagtgcagt ggcgcgatct cagctcactg caagctccgc ctcccgggtt cacgccattc 47580
tcctgcctca gcctcccgaa tagctgggac tacaggcgcc cgccaccgcg cccagctaat 47640
tttttgtatt tttagtagag acggggtttc actgtgttag ctaggatggt ctcgatctcc 47700
tgacctcgtg atctgcccac ctcggcctcc caaagtgctg ggattacagg cgtgagccac 47760
tgcgcccggc ctcaacattc ttaaagaaaa gaatttccaa cccagaattt catatcaggc 47820
caaattaagc ttcataagtg aagaagaaat aagatccttt tcagacaagc aaatgctgag 47880
ggaattgtta caaccaggac tgccctgcaa gtgctcctgc aggaagcact aaatatggaa 47940
agaaaaaact taccagccac cacaaaaaca cactgaagta cacagaccag tgacactatg 48000
aaggaaccac ataagcaagt tggcaaaata aacagctagc gtcatgatga caggatcaaa 48060
ttcacacata acaacactaa ccttaaatgt aaatgggcta aatgccccca ttaaaagaca 48120
gagaatggca agctggccaa agagcaaaga cccgtcagca tcagcaaaca cccagatgct 48180
gtcttccaga gacccatctc aagtgcagag acacacatag gttcaaaata aaggaatgga 48240
ggaaaattta ccaagcaaac ggaaaacaga aaaaagcaag ggttgcagtc ctagtttctg 48300
acaaaacaga ctttaaacca acaaagataa aatagacaag ggcattccat aatggtaaaa 48360
ggctcaattc aacaagtagc gctaagtatc ctaaatacat atgcacctaa tatgggaaca 48420
accagactca taaagcaagt tcttagagcc ctacaaagag acttagactc ccacacaata 48480
atagtgaaag actttaacac tccactgaca atattagaca gatcattgag acagaaaatt 48540
aacaaagata ttcaggacct gaactaaact ctagattgaa tggacctgat agttatctac 48600
agaactctcc acccaaaaac aacagaatat acattctttt catagccaca tggcactcta 48660
aaattgatca tataatcaga agtaaaacac tcctcagcaa atgcaaaaga actgaaatca 48720
taacaaacag tctctccaac cacagcacaa tcaaattaga actcaagaat aagaaattca 48780
ctcaaaacca tacaactaca tggaaatgaa caacctgctc ctgaatgact cctgggtgaa 48840
taatgaaatt aaggcagaaa tcaagaagtt ccttgaaact agtgacaaca aagagacagt 48900
gtaccagaat ctctgggaca cagcgaaagc tgtgttgaga gaaatttata gcactaaatg 48960
cccacatcaa aaagctagaa agatctcaaa tcaacaacct aacatcacaa ctaaaaaaac 49020
tagacaacca agagcaaaca aatcccaaag ctagcagaag acaagaaata accaagattg 49080
gagtggaact gaaggagata gagacacaaa aaaaaatttc aaaaaaccaa caaatccagg 49140
agctgatttt ttttgaaaaa aaaaaagtta ataaaataga ctgttaccta aactaataaa 49200
gaagaaagag aagaatcaaa tagacacaat gacaaatgat aggggggata tcaccactga 49260
cctcacagat acaaacaacc atcagagaat gctataaaca cctctatgca cataaactag 49320
aaaatctaga aggaatgggt aaattcctgg gcacaaacac ttgcccaaga ctgaaccagg 49380
aagaaattga atccctgaat agaccaataa tgagttctga aattcaggca gtaacaaata 49440
gcctagcaac caaaaaaagc ccaggaacag acgaatttac agctaaattc taccagaggt 49500
acaaagagga gctggtacca tttcttctga cactatttca aacaattgaa aaggagggac 49560
tcctccctaa ctcattctat gagaccaaca tcatcctgat accaaaacct ggcagagaca 49620
caataaaaaa acaaaacctc ggacaaatat ccctgatgaa catcaataca aaaatcctca 49680
ataaaatact ggcaaaccaa atccagcagc acatcaaaaa gcttatccac cacgatcaag 49740
ttgacttcat ccctgagatt caaggttggt tcaacatatg caaatcaata aacgtaactc 49800
atcacataaa ccacatgatt atctcgatag acacagaaaa ggcctttgat aaagttcaac 49860
atctcttcaa taaactctca ataaactaag tattgaggaa tatacctaaa aataacaaga 49920
accatctatg acaaacccac agccagtatc atactaagta ggcaaaagct ggaagcattc 49980
cccctgaaaa ctggcacaag acaaggatgg cgtctctcac cacttttatt caacctagta 50040
ttggaagttc tggccagggc aatcaggcaa gagaaagaaa taaagtgtat ctaaatagga 50100
agagaagaag tcaaactgtc tttgtttgca gatgacatga tcctatgtct agaaaacccc 50160
atcgtctcag cccaaaacct tcttaagctg ataagcaact tcagcaaagt ctcaggatac 50220
aaaatcaatg tgcaaaaatt gctaacattc ctataaacca acaacaggca agcagagagc 50280
caaatcatga atgaactccc attcacagtt gctacaaaga ataaaatacc taggaataca 50340
gctaacaagg gaagtgcagg gcctcttcaa ggagaactgc aaaccactgc tcaaggaaat 50400
cagagaggac acaagcaaat ggaaaaacat ttcatgctca tggataggta gaatcaatat 50460
tgtgaaaatg gccatatggc ccaaagaaat ttatagattg aatgctattc ctattaaact 50520
accattgaca ttcttcacag aattagaaaa aactattata aaattcatat ggaaccaaaa 50580
aacagcccca atagccccaa tatctttttg cttaggattc taagcaaaaa gaataaagct 50640
ggaggcatca tgctacctga catcagactg tagtacaaga ctacggtaaa caaaacctca 50700
tggtactggt acaaaaacag atacatagac caatggaaca gaatagagaa ctcagaaata 50760
agaccacaca cctacaaaca tctgatattc aacaaatctg acaaaaatga gcaatgggga 50820
aaggactccc tatttaataa atggtgctgc aaaaactggc tagccatatg tagaaaattg 50880
aaagtggacc ccttccttac accgtataca aaaattaact caagatggat taaagactta 50940
aatgtaaaac ccaaaactgt aaaatcccta gacgaaaatc taggcaatac cattcaggac 51000
atagacattt catgacgaaa atgccaaaag caattgcaac aaaaccaaaa attggcaaat 51060
ggggtctaat taaagagctt ctgcacagca aaagaaactg tcatcagagt gaacagacaa 51120
cctgcagaat gggagaaaat ttttgcaatc tatccatctg acaaaggtat aatatccaga 51180
atctacaagg aacttcaaca aatttacaag aaaaaaataa ccccattaaa aagtgggcaa 51240
agggcatgaa cagtcacttc tcaaaagaag acatacatgc agccagcaaa catgaaaaaa 51300
agctcaacat cacagatcat aagagaaatg caaatcaaaa ccacaataag aggtgggtgg 51360
gtcacttgag gtcaggagtt caagactaga tctagaatca gaaataccat ttgacccagc 51420
agtcttatta cggggtatat acccaggaat ataaatcatt ctattataaa gatacatgca 51480
tgcataactt cactgcagga ctattcacaa taacagagac atggaatgaa cccaaatgcc 51540
catcaatgat agactggata aagaaaatgt ggtacatata taccgtggaa tactatgcag 51600
ccataaaaag gaataagatc atgtcctttg cagggacctg gatggagcaa actaatgcag 51660
gaacagaaaa ccaaacactg catgttctca cttataagtg ggagctgaac tatgagaaca 51720
catagacaca tatggggaga acaacacaca ctggggcctg ttggggaagg ttgggggagg 51780
gagagcataa ggaagaacaa ctaatggatg ctgggcttaa tacctaggtg atgggttgat 51840
ctgtgcagca aaccacctgg cacatgttta cctatgtaac aaacctgcac aggtaccctg 51900
gaacttaaaa gttaaaaaaa ttttaaaaag aagagaactt cctcaacctg ataatgtgca 51960
tctataaaaa aacctatacc taacatcatt tttaatggta aaagaccgaa tcctttccca 52020
ttaggatcag aaagaagaca agatatccac tctcacgact tctattcaac actggaggtt 52080
ttagccagtg caataaggta agaaaaataa acaaaagtca cctacttttt aaaaaaagta 52140
agaatgaaaa tatttttacc ctcagatgac ctgatcacct atgtagaaaa tccagtgaaa 52200
catttaaaag gaagaaacag ggcaggcatg gtagctcacc cacccaaagt gtaatcccac 52260
cactttggga agctgagaca gaaggatcac ttgaggtcag gagttcaaaa ccagcctggg 52320
cacagagtga gaccttgtct ctataaaaaa ttaaaaaatt agctgggcat ggtggtgcat 52380
agctttagac ccaaacactt agaaggctga ggtgggagga ttgcttgaat ccaggagctt 52440
gaggctacag tgagctaaga ttgtgccact gcactccaaa ctgggtgaca gagccagacc 52500
ctatctctaa acaaaacaaa actactagaa ctaatacatg agtttagcaa ggttgcagga 52560
tacaagatca atgtacaaca ctcaactgta tttccatata ctaacaacaa ataattgaaa 52620
aagtgaaatt aaaagcaata ccatttacaa cagcatcaaa tagatgaaat atttagggat 52680
aacctaacaa acaatgtgaa atgcctgtac actgaaaact ttaaaacatt gctaagagaa 52740
tttttaaaaa tctaaataaa tggagataca ttgtgttgct gggttggaag actcaatatt 52800
gtttaaatgt cagttcttcc ctagttgatt tatagactta atccaataac agtcacattt 52860
cctttttttg tataaattga caaactgatt ataaaattca tgtgaaaata tgaaggacct 52920
agaatagaca aaacaacttt taaaaagaat gaagttggaa gactaggacc acctgatttc 52980
aagacatatt acaaaactaa cagtaatgca gacagtttgg tactgggcaa ggatagacat 53040
attcatcaac agaacagaat agactacaga aataaatcca catgtatatg gtcaactgat 53100
tttcaacaaa ggtacaaagg caattcagtg gagaagggac agtcttttca gcaaatactg 53160
ctggaacaaa tgtatatcca tatgcaaaaa tgaactttga tctagctaca tgttacacca 53220
tattaagaaa ttaactcaaa atggatcaca gacctattta taaaacctaa acctgtaaag 53280
tttataaaag aaaacatata agaaaaattt tgtgaccttg gaataagcaa atatttctta 53340
ggtacaatac caaaagcatg gtccataaaa gaaaacactg atgaattaga ctttttaatc 53400
attaagaaca tcttctcttt caaagagaat cttaagagaa tgagaaaaag ccacagacta 53460
gaataaaata tttgaaatca tatatctggc tgggtgtggt ggctcacgcc tgtaatccca 53520
gcactttagg aggttgaggt gggtggatca cctgaggtca ggagttcaag accagcctgg 53580
ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa aaaatgagcc atgcgtggtg 53640
gaggcacctg taatcgtagc tactcaggag gctgaggcag gagaattgct tgaactcagg 53700
aagcagaggt tgcagtgagc caagattgct ccattgcact ccagcctggg tgacaacagt 53760
gaaactccat ctcaaaaaaa aaagaaaaaa aaaaactcta aaaacgcaat acagtggtgc 53820
tcccttatct gtggttttgc tttccatggt ttcagttacc tgtggtcaac catggcctga 53880
aaatattaaa tggaatattc cagaaataac caattcatag gttttaaatt gtacaccttt 53940
ctgaggagca tggtgaaatc tcatgctgtt ccactctggc ccacccagga cacaaatact 54000
ccttttgtcc aacatatcca tgccatatac actacctgcc tgttagtctc ttagtagcca 54060
tcttgattat cagattgcct gtcatggtat tgaagtgctt tgtgttcaag taacccttat 54120
tttgcggtgg ccccaaagtt caagagtaat gatgctgaca tattgttata atttggtatg 54180
gtttggctct gtgtccccac ccaaatctca tctcaaattg taatcctcac atgtcaaggg 54240
agggacctgg tggaaggtga ttgggtgatg ggggcagttt ccctcatgct gttctcatga 54300
tagtgaggga gttctcacaa gatctggttg tttgttaagt gtctggccct ttcccctgca 54360
cactctctct ctcctgccac cttgtgaaag tgtgtcttgc ttcccctttg cctttcgcca 54420
ttattgtaag tttcctgagg cctccccagc catgcagaac tgtgagtcaa ttaaacctgt 54480
ttttctttat aaattattca gtctcatgta gtacctttat agcagtgtga gaacagacta 54540
atacataatt gttttattat tagttatggt tgccaatccc ttactgtgcc taatttataa 54600
attaaacttt attataggta tatatgtata agaaaaatca gtatatatgg ggctcagtac 54660
tatccatggt ttcaggcatc cactgggggt cttggaatgt atcccccctc agataagggg 54720
gactattgta ataagaaaac aattcaatat tttaaaatgg gtaaaagatt tcaacagata 54780
cttcaccaaa gaagatatat ggatgacaaa taagcatatg aaaagatgtc caataccatt 54840
actcattaag gaaatgcaaa ttaaaactac attaaaatac cactacacac tcattagaat 54900
ggctaaaatt aaaaagactg agtaaatccc atgttggcac acactgctga ggagaacata 54960
atttggtcca accacttcac tttggaaggc agtctgggag attatttatt tatttattcc 55020
attcctggct gatttttttt atagaaatag agtttcacta tgttcctcag gttggtctca 55080
aactcctggg ctgaagcaat ctgcctgtct tggcctctca aagtgctagc attgcaggca 55140
tgagccaccg cgcccggcca tggcagtttc tttaaaagtt cagcatatac ctatgatgtg 55200
atctagctat gccactctta ggtttttacc caagagaaat gaaactgcat gtccatacaa 55260
agacttgtac gccaatgttc atagcaactt tctttgtaat agccaaaaac tggaaatagc 55320
acaaataccc attagcaagt gaatggctaa acaaattgta gtatatccat acaatagaat 55380
cctgctcagc aatttaaaac atgaattatt gatacttgga agaacaaaga tgaatctcaa 55440
aataattaca ctgaatgaaa gaagccaggc aaaatgacta catgctatgt aaatccaatt 55500
ccacaaagtt ctataaaact aaactaatct attgttaact aatctgtagt gacagaagca 55560
gatcagtcgt tgcctgtgga tgagtagggt tggcaaagag tcaggaaagg aggatgacaa 55620
aggggcatgt ggaagctttt tggggtgatg gatatgttta taccttgatt atggtatttc 55680
acaggtgcat acatatatca aaacttatca aatcatgtac tttaaatatg tatgtcatgc 55740
actttaaatt gtgtgccagt tataccttaa taaagctagt aaaactatta tacattctta 55800
tttttctgag caggttctca tggagaacaa aatacaccat acctagtgtt cgttttcttt 55860
tttttaatta attaattaat tgatttttat tagtgttcat ttcaaaggac cttgctaggt 55920
gtcctaaaac ctatctgatg actttgcctg atactgatga ttttattatg attttaaaaa 55980
atatttttag tagagacggg ttttcgccat gttgggcagg ctggtctcga actcctgacc 56040
tcaagtgatc ttcccacctc agcctcccaa agtgctggga ttacaggagt gagccaccat 56100
gctcagccaa tactaataat tgatatggga gaatgttttg tttttcctag attcctcatg 56160
cagcttaata aggaccataa taacttaact cttagaacaa aggagatatt tcaggcccaa 56220
agggaagcac atctggtgcc tcctctgaaa ttcacaaaat aagggcgttg ttgtaagttc 56280
tgcatgaagc taaacttgtt caaagtttat aagttcaaaa gtaaataaaa ggactatctt 56340
ttattctgag accttatttc aatatcactt gtgataatga ttatagatcg tagctgttat 56400
ttacatattg ctacttctca gggttaaagg tggcatttcc acagcagtat ctgggatttt 56460
attgcctatg aaatcaagaa ggtagagtaa caagaattgt gtagggtatg agcttttacc 56520
ttacatgcaa gttaacaagt tagcctggta atgtttgatg gatgttagct aaagacatga 56580
gactcttggg tcagagaaaa aacacttgat tactcatggc aaaagcagta atcagaactt 56640
aatattgagc ttttactggt ttccatgccc cacgtgccat gaggggaatg aaagtcccat 56700
aatggatgtt tatggatgtt tgcacacaca cagtgggcta ccatttaagg agaggaatcc 56760
tgagcctggt aagtccactg cttttatagt gagttgtaac aagcctgttc tttgtctagg 56820
ggaagatgtt acctgatccc tcaaggttgc tcattacaaa cacaaccctg agaaatggcc 56880
tggataaaga gcagtcagag ccttgcttct tggcatacct gacaagaatg cacagagctg 56940
ctcagggccc ctggtaggtt tgcctcccac actagggact gtgcatggag gcacctgcca 57000
cttctgcctg catcctgggc tagcgtgaca gtcagagaca cagacaccag tgaatggctg 57060
aaatatgttc ctgtggtctt ctcactccac tacaacttcc ttcccagtta gggtccccat 57120
gcaggccctt tgagctgcac ctggcagagt tgagttacat actttcatgt accctgctga 57180
gtttgtcttc tttgccttca gaaattccaa catactacat gagtcatggt tcttggtatt 57240
attgttatac ccttctcaga atctctctga ctccccagat ttcacatcgt tttccatttt 57300
tgtaaaaggc ctcaaggtct ccatgctatg gagaagagtt atactcatct tttctttatt 57360
cttgcattcc tgaaagcctt acattagcat ccaagtgagg tttctctatc aatatcaaca 57420
gtaaatattt agtgaactaa acacctacta tgctcagcat aatgtataaa atatgattta 57480
agggttcctg ggagcttcaa atgcatcacc tgggtgcaaa aacatgagga aaccaaaaag 57540
tacattctgg tggttttttt aatagcattt aaaaaataat gccttgctgc agggatagga 57600
gctgtgctgc tttcatatca attctgttct ctttgtggtt tgagaaactg gagctgaagg 57660
gaaggtgatt gggaataaaa gaaagcagta ctgatttttc tggctaaaag aaagtttgca 57720
cactgtcatg cactattaga atttctggga tcttctttat aatccccggt ttgatggtta 57780
ttggccaaga aggaagaagg ggagctagtc aggcctagaa taattaccag ccatacagca 57840
taatctgggg ctagtgttgc agggtcaagg actgaatgag gcagagtgac caggagcaga 57900
tcctgcaagg ccttgaccaa aaaggaagct aaggttcata gaaggaaaat attgtattga 57960
tcatcaattc tagaggattg ggcatagagc caaaaatagg aggtgtatca tgagatcaaa 58020
agccattggt ggccaagcgc gatggctcac acctataatc ccagcacttt gggaggccaa 58080
ggcgagcaga tcacttgagg ccaggagttc aagaccagcc tggccaacat ggcaaaaccc 58140
tgtctctacc aaaaatataa aaattagctg gccatggtgg cacatgcatg taatcccagt 58200
actcaggagg ctgaggcagg agaatcactt gaacctggga ggcggaggtt gcagtgagcc 58260
gagatcatgc cactgtactc caacctgagt gacagagtga gaccctgtct caaaaaaaaa 58320
aaaagccact ggtatgtagg aatggtgcag gaaaaaagtg caaagcagaa atgaggtgaa 58380
aatatataga actatgaaca ggaatgaggt ctttcttgag tactggctgc cagatggagt 58440
acgagtgggt cagcagaagt taatgaggta ggttaaaagt taatgcatag gaatagtttc 58500
tgcacagtct tctgatgctg tccatcctgc agtcaggcct atatcaatat cagccctaga 58560
tgaagtggtc acaccctcct ttgtgcacct actgttacaa atagtcatgg ctgtcattac 58620
tccatcacag ctgatggcac ttactaggtt gagagaagcg gggctctgtc tcccttacca 58680
tacagtgagc tccttgagtt tattcatctt tgtgtttcca ttgtgcctgg actgcgcact 58740
gtttcccgaa tgaacaaatt aactggccta gaatatatct atgatgataa aggtcagttc 58800
ttagattatt gttttcattc tttaactgtt taagataatg tcaactctat gtaaaaattg 58860
tgccctaggt aagcagttgc tttttattat tattctctct ctttcttgat ggttactccc 58920
tctaggagcc caaagcatga cgtccagagc cccagattcc cagccatcct ggttgtgacc 58980
cttcattctc aactttcatt tcaatcttag tatgccatga aaagccgtct gcttttgaag 59040
cactatcagc cacagagttc tgtactttta gaaggccttc tcatagtcag attctcacaa 59100
atatacctat tgtttcaata aatatttatt gaattggcca gcaatgtttc agatactgtt 59160
ctaggtgctg gggttacatc aaagaacaag gtaggcaaaa tcactaccct cgtggacttt 59220
gctttcctgg agggggaata ggcaggacat aaaataaatt gtaaactatt cgggatgtta 59280
gtgatcagag aagaaaagta aaacagggac agtgaatggg gactgtcaga gtggtagttg 59340
ctattcaaga tcatttgacc aaggaaggcc tcgctgagga agtaacattt gagaatagac 59400
ttgaaaggca taaaaaaaca agtcattagg taaaaaccat tccaggcaga aggaacaaat 59460
aatgcaaagg gccagggatg gaaacatctg tagtgttcag gggaaagcaa ggaggccagt 59520
gtgactggag cagagtagat taggcaaaga acaggagtag ataagatcag caaggtaatg 59580
ggtgccacat cacgtaaggt cacacaggac agtgtaatga ctttggcttt tactctgtta 59640
tggggagcca ttgcaggatt gggagctgtg aaatggcaca ccttgcttac atctaatagg 59700
aaatctgctg ctgcattgag aatagacctt taaattttaa aagagatatc tatggcatta 59760
ccttaaataa agtcatgctc cttggagtgc ctcaattcat gtacattaat gggtaaaagt 59820
ggaattcaag aaaccctgga aatgtatggg ggagtcctct ttgtttctcc tctgctcatg 59880
tctggtgggt gagcactaac gccatctctt cctaagcgag ggctccctag cagagcaccg 59940
tgcacatgga ttcttcctat gctctgcatt ctttgccaca gggatgccat aatttggcaa 60000
tatgcagtag agactgcctc aagaggcagt tcccttcttt atctaagcca agagaaattt 60060
ggttctgcaa gtaacaagta attactgctg atgacattcc ttgtacacac ttgaagagag 60120
cgtggaccgc aaaataaaaa ctggagcaaa aagggactat cagataatcc agattaaaga 60180
ttggaaagga ggaaaacaca ttatttacac atacaacact tgattttatg agtagagaac 60240
acaacttatg tgtatgtacg ttgtacactt gattatatgt gtagagaatt caaaagtgtt 60300
cagataaatt atttagactt aaaaagagac aaataatttt gggaaggtga tagtggcagt 60360
agtagcatag gttttagata ttcctgaatc tccacataaa aacagcaact agatagaaga 60420
cacaaaactc atgggcaaca aaataaaatc catttacaag aaaattagat gatgaggtat 60480
tcttatgatc ctcaaaatat aaccggttgg ggaaagacca cccacagcca caagagctgt 60540
gttatttgtg tctacgtagg agaaataaga gagaggcaat ggacatctga cagacctgag 60600
aacagagaac tcaaaatagc ccaaaggtat tcactggaaa gcatgggtgg ggcaatttga 60660
gatcagcagc tgaaacttaa taaggggtga gtgcaaggga tccacctctg gaaggtctaa 60720
aaggaatgca gcagtctagc tgctgtgaaa tttctagact gatctggtgg ggctcccttc 60780
caagatagga tctcatgaag aagagaaact gtggggagta ttgagctcaa aattgagcag 60840
aatgaagaca atacagatga agaaggaaga ggaatatcca aatgaaagca tatcagagtc 60900
aggaaatctc cttggaaagc aagccagagt attttttaac accatattaa tacaatatag 60960
caaaggaacc atgtgaagtt agaaaagcta tctgaaccaa atgtcttttt aaaatcacat 61020
aaaaactaaa ttcacaccca caaaaatcta cagcaggaaa atatcaaggc caaatccaac 61080
acaacattat taacctaaga aagagaataa ggggaatatc tgcagacaat gaaagcatgc 61140
caaaaagata tgattgaaaa tagattgaga ccctaatgta ctatttcagg tgcattcaaa 61200
gacattgaag aagtcatata agacatagaa aagcaacata aatcaaatta ggaagctcag 61260
aaatgagaca attcaagaaa aaattagaaa taaacatcta aaaatgaagg ctgatctaga 61320
aggaactcaa caacaaatga atacaacata attctttaac ataaataaaa ggtagaaagg 61380
aagaaaattt tttaaatgga atgaaaaaag atttttaaaa agttttgaaa gaaaacaaca 61440
aatattgaaa ataggcaaaa aagatcaatt tatcaataat aagagtccct gaaaaagaaa 61500
ataaaagcaa ggaaagaaaa caagtataaa acaaacaaaa ccctctaatt taagaaaact 61560
gaaaatttga aactacgtat ggaaagaaca cactgtgtac ttgagtatat cataatgact 61620
aagttcagca gagttgttgg atgaaaggtc tatgtgtaaa caccatttta tgtaacattt 61680
aaacaaattt tttagatcat ttaaaacagc ataaaaaata taaaatccta tttgtgacgg 61740
ctttctagtg tgtcaacttg actaggccaa actacatttc ctagaattct ctttcttgta 61800
tgttttctga ccacaaagga gattctttct agatttggaa agctaaggga agttccagcc 61860
atcttatagc acacacattg ttgcgaacct gctgatccac ctactggggt gaagcagagc 61920
tggacatgca attgctctac cttcccctgg accctccatt aacttgtcag gcccctgggc 61980
caggtgtgtg tgattagctc cacgacaaag ggccacagct tctgcaggat atactcatta 62040
cctagatcag aggcaacaat aactgacatg ggtttcagtc tcttcacagg ggtgtgagca 62100
tgctctaatc tcttgatttt ccctcctgac tgcctgcctt gtagacttca agctctagca 62160
tcagatgtgg agacaacagc cttacagaga ctgcttaaag agctcccaaa attgcataac 62220
tcaactgcct gtgacacatc catatatctc tttttgaatc ctggctaata cagtaggaaa 62280
agatatgcat tatctctata tagaaaatca taaaatattt tgagaggaat taaattctat 62340
attcattgat cagaagactt aatattgtaa aaatatcatt tctccccaga ttgatatata 62400
ggttcaatgc aatagaaatt ccaacaactt gcatatgtgt gtgtgaaact tgacaagcta 62460
aatctcaaat ttatacggaa attcaaaggg ctaaaaatag gctggaaaga aaaggacaag 62520
ctgggcgcgg tggctcacgc ctgtaatccc agcacttttg gaggccaagg cgggcagatc 62580
acatgaggtc gggagttcga gaccagcctg gccaacatgg cgaaacaccc tctctactaa 62640
aaatacaaaa atttgccggg catggtgggg ggcgcttgta atcctagcta cttaggaggc 62700
tgaggcagga gaatcacttg aacccaggag gcagaggttg cagtaagcca agatggcacc 62760
attgcactcc agcctggatg ataagagtga aactctgtct aaaaaaaaaa aaaaaaaata 62820
ggacaaagtg agaggatttc ttcttctgga tatcaatatt tactataaag ctagtaatta 62880
aaacctgcta aatatggtat tggagcaagg agagacaaat agatcaatag aacagaatag 62940
agagaatcca gaaagagtca aggatatata gatgcttttc aataaatggt gcagggtcag 63000
ttggctatcc acatggagaa aaaagtgcaa cctgaatcca cctcaacaaa attacttcca 63060
ggtgaactac tgaaatggaa aacaaaaaaa cttcaggaaa gtcatagaag agagtatctt 63120
tatgaactag ggacatgaaa atatgttaaa cagaacacaa caagtattat tcataaggga 63180
aaatattgtt aaattgctct acattcgttc aggagcagcc tgggcaacat ggcaaaatgc 63240
cgtctctgct aaaaatacaa aaatacagcc aggcatcgtg gtgcatgcct gtggtcccag 63300
ctactctaga ggctgaggtg ggaggatcac tggagcctgg gaggcagagg tcacagtgag 63360
ctgagatcac gccattgcac tccagcctgg gtgggtgaca gaggaagacc ctgtctaaat 63420
tgaaaaaaaa aaaaaagctc tacattagaa attgagaact tctgttcatt aaggacatca 63480
ctaaggaaaa aggcaagcca tagactggga caatgtattc acaatgcata tgtcatcaaa 63540
gaatctttat tcagaataaa aaagtgggaa tctatatgaa aacatagaaa atccactttt 63600
ttaaaaatgt gcagtcttat gtttatcaca gcactgttca cagtagtaaa gtcatagaat 63660
ccatctaagt gtccatcaac agatgattgg attaaaatgt ggtatatttt tgccatggaa 63720
tactatacac ctataaaaat aaatgaaatt atgtcttttg cagcaatgtg gatggaactg 63780
gaagccatta tgcttactga aatgactcag aaacagaaaa tcaaaaacca catgttctga 63840
ttgataagtg ggagctaaac agtgggtata cacggacata caaggggcat aatagacact 63900
ggagactcca aatggtggga ggatgggagt gggtgaggga tgaaatacca cctttcaagt 63960
acagttcagg tgattggtac acttaatgcc cagatttcac cactgtgtaa tatatccatg 64020
taacagaact gcatttgtat ccctaaatcc ataaaaataa aaaaatttaa tttcaaaaaa 64080
taaaaaatgt gcaaaagata tgaacaggta catcacaaaa gaacaaatcc agatagccaa 64140
taaacaaatg aaaaagggct caacttcatt agtcatcaga gaaatgcaaa ttaaagccac 64200
agtgtgataa tactacatac tcacttgaat gtctgcaatt aaaaaaaaga ctgacaaaac 64260
caagtgttga gaaggatgta gaacaactgg aattctcatg catagtgtgg aagtgtgcat 64320
tgatacaatc acttttgaaa actgtttagc agtatctact aaacttgaac atattcatac 64380
cctgtgtcct agcaattcca gcaaaattgc atacatatat tcaccaaaat aatgcactag 64440
aatattcata gcaacactat ttgtaatagg cccaaattgt aaactgtttg aatgtccatc 64500
aacagttata atatctattt ataatgtcca atatatcaca gtatactcca tgccacaata 64560
tagatggctc tcacaaaaat aataaatagt gttgagcaaa ggaagccaga aaaagagatt 64620
ataccctatg ttactctttt tacatgatgc acaaaaacag gcagagctaa tctaagatgt 64680
tagaagtcag attgggtggg tggagaaaag ggagaataga gcaagaggaa gacttctgaa 64740
gcactaataa tatgtttttt gacttgcatg ctggttgccc aggtgtgtca gtttttgaaa 64800
attcagtgaa ttatacattt atatatatgc atttttgttt atgcatattt ttcttcagca 64860
aaagtttaaa aaataatctt tgggcttcct gaaaagataa aaaggaaacg tttaaaggat 64920
acatgtcaat tttttagcag agacaaaatt tttaaatact attttctgaa aaaaaattct 64980
ccctcacagc tttatattta ttattaatat tgaaggatat aatgaatagt tttactgtaa 65040
atgcagaagt aaattttata agacttgttt atggcaccat taggaatagt ttttaaaaat 65100
cagaacttgt gtttatcaaa agacactatt aaatgacacc aaaagcacaa gtaacaaaag 65160
aaaaatgtgt ttaatatcat caaaattaaa aatttctggc caggcaccgt ggctcacgcc 65220
tgtaatccca gtactttggg aggccgaggc aggcagatca caaggtcagg agtttgagac 65280
cagcctgacc aacacggtga aaccccatct ctactaaaaa tacaacaaat tagccaggca 65340
ttgtggtgcg cacctgtaat cccagctact tgggaggctg aggcaagaga atcgctcgaa 65400
cccaggaggt ggaggttgta gtgagcgaga tcttgccact gcactccagc ctgggtgaca 65460
gagcaagact ccacctcaaa aaaaaaaaaa aaaaaaaatt ctgtgcttca gataacacca 65520
ttaagaaagt aaaaagaacc tacagaatga agaaaacgtt ttcaaattat ataatagacc 65580
tgataaggga ctcacatcta gatatataaa gaatgcttac aactcaataa tacaaagaca 65640
aataaaacaa tttttaagtg ggcaaagaat ctgaatagaa gtatctcaaa aaagatatat 65700
gaatggccag taggcacatc attaccccta agggaaatca aaatcacaat gagttaccac 65760
tttgcatccc ctaagatggc tataatataa aaattaacaa gtgtttgtga ggctgtggag 65820
agattagaac cctcattcac tcctcctagg gatgtaaaat agtgtctgag ctagggaaat 65880
agtttggcag tttcccaaaa tgttaaacat agggttacca tatgactcag tgattaagct 65940
cctaggtata tactcaagaa aatcaaaaca tatgtccatg taaaaacttg tacatgaata 66000
ttgatagcag cattgtttat aatatcccta aaaggaaaca acccaaacat gtatcaacta 66060
ttgaatggat aagtgaaatg tgttatatcc atacagtgaa atattattca gcaattaaag 66120
tgacacactg actcatgcta ggacatggat gaaacttgaa aacatgatgt taggtgaaag 66180
aagctagtcg caaaagatca catttgattc catttatatg aaatgaccaa aatagacaaa 66240
tctataggga cagaaaggag attcgtggtt atatgtggct ggggaaatgc aaattaaaac 66300
tactaggaga tacataccga tggtatgtat gcttatcttt aaattatctt taaatttttt 66360
aagataataa gataaagatg tgaaactatg aaactctcat ttactcactg ggagggtata 66420
aactggtaca accacattag aaaagaaatt ggcgtatctt ttaagattaa caacacatat 66480
accttgagag ccagcaaatc catttctaaa ttctactcag tagaactatg tgcatattta 66540
tatcaatagg tgtacaaaaa tattcatagc agcattattg taatcaccca aatgttcatc 66600
agaagtataa ggaataaata aattgtggta tattcctgca atgggatatt atatagcagc 66660
tacagttaca cccagcaaca tgtataaatc tcacaaacaa catcaaataa aaaagccaac 66720
cacaaagtag catccactat gattcccatt tatgaagttt aaaaacaggc ataactcaac 66780
tatagtatta aaagtcaata tagtagttca ccttaaggga gaagggaaag agtaaaaagt 66840
ataatatgag gtagaatttt gaggtattgt aatgttctct ttcttgggtt atagttttct 66900
atatgatgtt ttctttgtta caatttactg agctatacat ttttaatttg tacacttaaa 66960
aatacatttc ctggccaggc gtggtggctc gtgcctgtaa tcccagcact ttgggaggct 67020
gaggcaggca gatcaggaga ttgagaccat cctggctaac acagtgaaac cctgtctcta 67080
ctaaaaatac acaacaaaaa ttagccaggc gtggtggcgg gcacctgtag tcccagctac 67140
tcaggaggct gaggcaggag aatggcgtga acctaggagg cggagcttgc agtgagccga 67200
gattgcacca ctgcacttca gcctgggtga cagagcaaga ttctttcaaa aaaaaaatat 67260
atatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtatgtgt gtgtgtgtgt gtctgtgtgt 67320
gtgtgtgtgt attctggccc aagattatag ttttttttaa ggcagtctgt caggggtcta 67380
caattgtatg agttataaat aaggagtgac aatatcttca gtgaactcct gaacatgaaa 67440
accaagggtc gactgcgaat accttcttta catacaacca gacattatgg aatgaatgtg 67500
ttccccccaa attcatatgt tgaagctcta actcccagtg tgtctgtatt tggagatagg 67560
gtctttgggg aagtaattaa agttaaatta ggtcatacaa cctacagaat tggagaaaat 67620
atttgcaaac tgtgcatctg acaatggtct aatacccagc atctataaga aacttaaatt 67680
tacaagaaaa aactaacaac cctatgaaaa agtgggcaga gttaattttt tcatgagcaa 67740
tggaaaaaaa ttaaaaagtc tgaaagcagg caaagaacat gaacagacac ttttcaaaag 67800
aagacataca tgcagccaac aggcatatga aaaaaagctt agtatcactg atcattagag 67860
aaatgcaaat caaaaccaca atgagatacc atctcacacc aattggaatg gctactatta 67920
aaaagtcaaa aaataacatg ctggcaagat cgcagagaaa aatgaacaca tacactgttg 67980
gtaggagagt aaattagttc aacattgtgg aaagcagtgt ggcgactcct caaagagcta 68040
aaaacagaac taccattcac cagcaattcc atttgtggtt gtatacccaa aggagtataa 68100
atcattctac cataaagacg caggcacatg aatgttcatt gcagcactat tcacaatagt 68160
aaaggcatgg aatcaaccta aatgcccatc aatggcagat tggataaaga aaatgtggta 68220
catatacacc atggaatact atgcagccat aaaaaagaat gagatgatgt cttttgtttg 68280
aacatggata gagctagagg ccattatcct tagcaaacca acacaggaac agaaaaccaa 68340
atactgcatg ttctcactta taagtaggaa ctaaatgatg agaacacatg gacacaaaga 68400
gaggaaaaac acacactaca cactacctga gggtggaaga tgggaggagg gagataatta 68460
gaaaaaataa ctgttaagtc ctaggcttag aacctgggtg acaaagtatt ctgaacaaca 68520
aaccccccga cacgagttta cctgtataac aaacctgcac atgtacccat gaacttcaaa 68580
taaaagtctg tgtgtttttt aaggcagaag tcagccccta ccttgaaaga actttctaca 68640
tagatggcta cagtgttact gagcgttttt tttttggtct atcctgaatg tcatgggaaa 68700
acttttaaac tgctctggat caagattagt gcctgtggta tttcatttct cctactcaac 68760
tgttgcagtt acatgatctt agaaattctt tttggcatat tgatgactgt tatcattcaa 68820
gttacatcaa gagagacttc tttctatgag gagctattaa gaccctcttt tggacacata 68880
cacaacttca atttacatct aagacaactt attttaatga aattgcttat ttgtttgctt 68940
tagtccttag attatatgat catttgggca gggactattc tttgaatatt tcctggcaca 69000
tttttgtctc aataaagagg aaggtgaagg aagaaagaaa ggaaaggaag aagggaggga 69060
ggaaggcatt cttgttttct atatcctaaa cctataattt tgtcaaaaaa gaatattaaa 69120
tttgcctaaa atgttaacaa aaaataggtc ataatgatgg ggccctaatt caacagggct 69180
ggtgtcccta taagaggaag aggcattgaa gtttgctctc cctgcatgca caaagagact 69240
atgtgaggac acagcaaaag gacagctgtc tacaaaccag gaagaggcct cgccagaaat 69300
cagcccttga aaaaacctgg gtcttggact ttttgcctcc acaactgtga gaaaataaat 69360
ttctgttgtt taagccaccc agcctgtggt gttttgttat ggcagcccga gcagactgat 69420
acaccagaca ttcactgtat ccaactgttt caccataata gcctttctta ttttgatcaa 69480
attactgcat caggatttga tcttaaattt catgtttcct ttgcttttgt aaatgtagct 69540
gagcatccaa atttcactca gtttggatgc taacaagatt agacagttat ctgacagtaa 69600
tcagtgcctg atcctattct gtgtcttctt ccatcaccat cccactaaag agcttgcatt 69660
ttttgtttct tttagccaga tagtaaacat ttttcaggca ttttgaattt tgccattgta 69720
aatggtgaaa gattctctct ctctctctct ctctctctct ctctctctgt gtgtgtgtgt 69780
gtgtgtgtgt gtgtgtgtgt attaggaggg ggtggtgatc gggatgctaa tctatgcaca 69840
gtgacctttg tttctatctg gctgagcaga tgtaggaatt aatcattgtc actcctggat 69900
ggtgctgctg cagctgtccc ccactgcctt tctgcccctg atagatttat tagtgtgttt 69960
tgtttgctga aaagcatgcc tcagcacaga agaactggca aattagagaa gctttatctg 70020
tgagtataat tttttggaaa catggttttt tctacacatc tgtacctata tactctgagc 70080
tctttaaaaa aaaggaggag gaagagagca aagaaagaaa aggaaaacaa acaggtaata 70140
ttgtttctgt aacatcagaa cgattatttc ccagctgaga atgttcatac tggaacagtg 70200
tcatggccat ccaccttagg attgcagaga accaattgtt ttctaacctc tgtatttctt 70260
tttgcaactg cccaccccct cacccactta actgccaact atcagccaga attttggcat 70320
actttggctc taggcacaag aaaataagtg gtctgggtta cttagtgcta aatttatttt 70380
atagtaggcg tcactacaac cttgagactg taactaacac tttctaggct ccaagcaacc 70440
ccactacgta gatatccctg cagcctcatc aaattcaacc cgtggggata ttgataccgt 70500
cctggatgga aatcagagta gccacacccc tttcaatgtt gggaatctgc caaacaattc 70560
agtataaatt tcctgggcct gggctgtgta ttttcattcc accccacccc caaatcagtc 70620
agcatgccct ggggcagaga ctaaagagcc gccagtgcct attcagagtt ggcttattcc 70680
tttctgatgg cccatcccct ccccgaaatc caagaccttg gccttagata tcttggctag 70740
cctgggcctt tctggtacca cccttcactc tctaggagct ctgagaattt tctgcacttc 70800
ccgacgctgc ttgatagagt gactcacagc ttactctttc attgactctt tctgtatttc 70860
tcttcttcag aatttctctt ctgctgctgc ttttagacat ccttgcatgt tcagtcccta 70920
aatcaccact gcttgttatt actttcatgt tcccaacatc tggcatatgg gtcttaatcc 70980
catgggtcca cccagactca tgaatttaaa ctcttctggt ctaaactctt ccaccaccat 71040
ttgagcctca attctgtgaa cagttttgtc tctaaaagcc acatacctta gtgtaagaag 71100
gcagattaat cctctgaatg tcaacttaac agttaggcct atctcccaag aaagagaaat 71160
gaaaactcct aattagtaat gactcatttt gatcaaataa tcaatttttg gaccattttc 71220
ttaaaactat attttattgc ctgtaactat ttcctggagg ataataatca tccttaaatt 71280
actatgtgtt ttgtgaagtt ggtgctttac ttttcgtgtc ctaaatatgc atatctgaat 71340
ctttaaattg tagcttctct ttcaagtgtt ctaggatttc atttgccatg gttgggatct 71400
ctttgtgatt tgataggttt cgatcacatc ctcactagcc ttctttccaa gccacagaac 71460
ggtctgtctt cattcagtag agaccctgcc attctagttt tctcgctgga atttgttttc 71520
ccatatcctt cttgagcaaa ggtgactaaa gccaaatgtt tcattctggc actttgtgag 71580
acgtgggctt taagctctca aaagaagaga aaatctcata gttttatatg agatatacaa 71640
tgaacaatag taaaatagaa atgttattgg caagaggagt ttttctccaa tatccatgag 71700
taagaattcc ttggacacat aagataacaa gaggaatata cttactctgt tttccttttg 71760
agatattctt tacataccat gaagttttcc tttctaaagt ttgcaattta atagttttta 71820
gtatattcac aagcttgggt aaccaccatc actatctaat tccagaacat ttttatcacc 71880
tgcaaacaaa accttgtacc tgttagcagt ctctcctcat ttctctcttc ctcccacacc 71940
tggaaaccac tagtctactt tctatctcta tagatttgcc tattctggac atttcatata 72000
aatggaatta ttgaacatgg ggccctttgt gtctggcttt tctcatttag cataatctta 72060
gcataatatt tataaggttt ccctgtgttg tagcataaag cgttacttca ttccttttca 72120
tggctgaaca tcccattata tggatattcc acattttgtt tatccattca tcagttgatg 72180
ctatctgttg tttccacttt gaggctctta agaataatat gctgctgtga acatttgtgt 72240
acaagttttt tcatgaacat gtttttactt atctgggtat atacctagga gtggagttcc 72300
tgggttatat ggtgactgtt taacataagt gtagaactgt ttttcaaagt gactatacta 72360
tttcacaatc ccaccaacaa tgtatgaggg ttccagtttc cctacatcat cactaacact 72420
tgttttatta tctgcctttt taattctagc catcctagtg ggtatctcat tgtggttttg 72480
agtcgtattt cccttatgac caatgatgct gagtgtcttt ttatgtactt attatccatt 72540
tgcttatctt ccctggagaa ctgtctattc aaatcctttg acatttaaaa aaattagatt 72600
gtcttggggc cgggtgcggt ggctcatgcc tgtaatccca gcactttggg aggctaaggc 72660
aggcagatca cctgaggtca ggagtttgag accagcctgg ccacatgctg aaaccccatc 72720
tctactaaaa atacaaaaat tagctgggta ttggtggcac atgcctgtaa tcccagctac 72780
tctggaggct gaggcaggag aatcacttga acccaggaga cggaggtttc agtcagccga 72840
gattgtgcca ctgcactcca gcctgggcga cagagtgagg ctctgtctca gaaaaataat 72900
aaataaataa ataaataaat attgtcttgg aaatatactt aaattaattg gcctatagtc 72960
ccagctactc aggaggctga ggtgggagga ttgcctgagc ccaggagttt gatgtttcag 73020
tgagctatga ttatgtcact gctctccagc ctgggtgaca gagtgagccc ccatctctga 73080
aaaaaaaaag gaagaaagag gaagaggaag aagaggagga ggagaaggag aagaagaaat 73140
gctcttaagt caatagttct caaacttggt tcacattaaa gtttcctaaa atcctgatgc 73200
tcaggcttta ccctaggcca gttaaatgat aatatcttgg ggtaggaccc aggcaacagt 73260
tttagaaaca aatctccagt tgattctaat gtttgagagc cattgctata gactacatga 73320
ctaagctgat gataccaata taaaaatgtt aaagatttga taatttagaa attatgccag 73380
gtattaaaaa tgggagactt aactcaaatg tgaatcataa aatgcctaat caggtcaaaa 73440
gatagagttg agatttgtaa taaagattga taaactttcc tataatagga agtttcaaac 73500
cacctatagc tagagaaaat gtctggctgt ggttcttgcc tagtgagcag gaattggttt 73560
tatgaggtaa ccatgggaga gccaataaat gtgagtgatc atgacaatta aatctttaag 73620
cccagataat ttatgtcaat tattcaatgt tcattaagga aagtgaaaaa aaatgagtat 73680
tagctaggag aaatggaaag ggaggctttt gaaaggcata aaaagattgg aggctatttt 73740
aagagacttt attggaagca tagaaaaaga gtatctgaga atttttaaaa atccaatcac 73800
ataaaaatgt gacagtcaca gtggttattg tggagggaaa atgacatctc tcaaagaatg 73860
taaaaagctc cccaagggag agcagggagc ccacagagtg tattaggtta agtacaaaat 73920
aggaaaaaag actttaagaa acactttcga agagagtcca aaacacataa agggattatt 73980
taaaatctat taaaaggaag aagctagaat aacagtggga tcttttgctg agaataaggg 74040
ggcacaggga gtgctgaggc accaaaagac aatagacaaa ctaattatgt gcctctgaat 74100
gtattgagaa agataccaga gtgatagcac attcaaattg cctactacga atggatcagt 74160
agtagttaat tcaatggttt tctgtgtttt gcatatttca agtcaggtag gcagaataaa 74220
tactgattaa tcactggaaa ctcttggtgt ttatcttgag atttctgaag gcctccagaa 74280
gaaatttttc tcgtcttgcc tctccctaaa gccactgccc ttgtcctccc tctcctatta 74340
ccaccaaggc tcctaagtgt atagtctacc ctagtcacct cactttctca tctccaattc 74400
attcttcaac ccattcttct aactccattg aaaggtcatt aaatctgact cattgccaaa 74460
gtcattaaat caacagatcg ctttttagac taaattcttt ctagccttta gatatataac 74520
accattaact gtttcttctg ttcttccttt ctgaaacctc ttttcttaac atttattata 74580
tgtgaatgtc ctggttttac ctgtctactt cttgctagct accttcactg gctccagaat 74640
tacttacgta tttctctttt ttgttttttt tttttaaggc tagtcaagtg aagcagtggg 74700
aatggagaag gaacacagaa atctgtaact ggttgtgatc aattaattgt agacactact 74760
gacttcagac aagccttacc tatttaattt tggtaacact ctgggttcca gtctcgattc 74820
acttcttaca ctatatcctt caccttgttt taacctctcc tgtgacatat cctagtgctg 74880
cctctcttcc cattttctaa cttcatggtt gatatagtca tatagatgtt tcacagttta 74940
ttctgatcca gtaaccaaaa ccagattaat atcttaccag caaacttgct cttcctttgt 75000
gtaattcctg tcgtggttaa tagcactacc atccacccgt tctcattctg gattcctttg 75060
tctccctaca catccggcta gttaccaggt tttagatatt taacctctga aatgtctttc 75120
aaatctttct attgtccatc tccattgccc aaccatagtc ttcatttgtt tttcatctgg 75180
actattgcaa tagtccccta actcatcttg ccgacatttt cagctactga tctcttgcca 75240
gcattttttt ttccccaaac acaatctagt tttaaaatac agacttctac tgcctacata 75300
actccttagg taagtattta aggtcttttg tagtctggcc ctaacataaa atatccactt 75360
ttccccttga aattaagttg tgccctggtc gtacatgaga atggccattc cttgagcaca 75420
ccatgcacat tcctcaccat gtctttgttc atgctcttcc ttgtttcaca actcttctca 75480
tttatcacct gacaaactcc tatctatcct ttaagacaaa tttctgtctc tcaaaatgtg 75540
ggccctgggc cagagcagca gtatcacctg ggaacttgtt agaatacaac ttcttggggc 75600
cccactttag actctgttta atccaaaact ttgtgtgata aggaccagca atgtgaattt 75660
taacaagctc accacatgat tctgatgcat tctaaaattt aagaaccact gttctaggga 75720
acaatttttt tatcaatggc catagcactt tacacatacc tgtattactt actgcattat 75780
ttaataacca tgtttactta ttcacttatt tatctggtct gctaagttgt gagtccccag 75840
agtcaaatac aatggtgctg tgttctgaca cctgccatag tgtctagcac ataacaagtg 75900
cttgataaga attcagcata ctaaaatata cccccttccc tccaggattc agtctagcta 75960
gagtaaatag agagggcaag atcaaatggt gtccaaggca tctactctta aaggtcgata 76020
tacaccacac aaaccaaaag cttacacact gacaataaca aatgtcagca aagtaataac 76080
caacgggtac taggcttaat acctgggtga taaaataatc tgtacagcaa actccaatga 76140
tactaattta cctatgtaac aaatatacac ttgtacccct gagcttaaaa taaaagtttt 76200
taaaaaaata aataaagcaa atgtcagcaa ggatgcagag aagctgaatc tctcatacat 76260
tgctgatgta cctactctgg aagacacttt agaagtttct tataaaatta ttccctcact 76320
gtgcgattca gcagtttcac tcctgtgtat ttaccgtaga gaagtaacta tgtatgttca 76380
cacaaaaagc tgtatgcaaa tgttttttag cagctttgtt tgtaatagtc aaaaactgga 76440
aacattaaca atcaaaaaag aaatcaagaa aacaattcca tttgtaatcg catcaaaaaa 76500
tgaaaacttg ggaaaaaatt ttacctaaaa gatgaaagac ctatacactg aaaactataa 76560
aacactgatg aaataaatga ggaaggcaca aatcaatgga aagatatccc atattcatgg 76620
attgaaaaaa tttatattgt taaaatagcc atactaccaa agcaatctac aaatgcaatg 76680
caatcttacc aaaattctga tggtgttttt cacagaaata tgaaaaaaac taaaattctt 76740
atggaaccac aaaagacccc aaatagccaa aacaatcttc accaataaga acaaagctgg 76800
aggtatcacc ctagcctatt taatttcaaa atctactata aagctatagt aatcaaaaca 76860
gcatgatgct ggcataaaaa cagacaaacc aatggaacag aatagagagc ccaaaaataa 76920
atccatccac ttacagtcag ttgatttttg acaaaagtac caagaaaaca caaaagagaa 76980
aggacagcct cttcaataaa tggtgttggg acaactatgt atccacatgc aaaagaatga 77040
aattatgcct gttaccccag cactttggaa ggccaaggtg ggccgatcac ttgaggtcaa 77100
gagtggagac cagcctggcc aacatggtga aaccctgtct ctattaaaaa tacaaaaatt 77160
agccaggtat ggtggcatgc acctgtaatc ccagctactt gggaggctga ggcaggagaa 77220
tcatttggac ccaggaggca gaggttgcag tgagctgaga tcgcaccact gcactccagc 77280
ctgggcaaca gagagagacc ctgtcttaaa aaaaaaaaaa aaaaaagaaa ttggacattg 77340
gacccttata ccatatacaa aaaatccact caaaaatgaa ttaaaagctt aaatgtatga 77400
cctgatactg taaaaactat cagaataaaa cacaggagaa aagctcctgc cattggtccg 77460
ggcaatgatt ttttggttat ggccccaaaa gcacaggcaa caaaacaaaa catagacaaa 77520
tgggattaaa ctaaaaagtt tttgcacagc aatggaaaca ataaacagag tgaagagaca 77580
acctacagaa tgggagaaaa tatttgcaaa ccatacatct ggtaaggggt aaatattcaa 77640
agactataag gaactcaaat caatagcaag aaaacaaata atccaataaa aagtggacaa 77700
aggacctgaa tagacacttc tcaaaagaaa acatacaaat gtccagcagg tatatgaaaa 77760
aattctcaca tcactgatca tcaagaaatg caaattaaaa ccatgagtta ttagctcata 77820
cctgttagaa tggctcttat gaaaaagaga gatagcaaga gttggggagg atttggagaa 77880
aagggaaccc tatacactat ttgtgaggat gtaaattagt acaactatta tggaaaacgg 77940
tatggaggtt cctcaaaaaa ttaaaaatag aactatcata taatcaagca attctacttc 78000
tgggtgtgta tctaaaggaa atgaaatcag tgtatgaaag agatacctgc actcccatgt 78060
tcactgcaac attattccca atagccaaga tatggaacca acctaagtgt tcatttacta 78120
atgaatggat aaagaaaatg tgagatatat atgtacacat acacacacac gatggagtac 78180
tatttagtct taaagaagga aatcctggca tttgcaaaaa catggatgaa cctggaagac 78240
attatgctaa gtgaaataag caagacatag aaaaacaaat actacatgat ctcacttaca 78300
tgtggaatct aaaaaagttg aactcataga agcagagagt agaatggtag ttgccacaga 78360
ctagggtgga ggtggttgac agaaatggag agatgttggt cagatcaaag agcacaaagt 78420
tccaggtagg acagataagt tgtggagagc tatacagtat agtgtctata attagtaata 78480
acgtgttgta tacttgaaga attccaagag agtatgtctt aaatgttctc accataaaaa 78540
aagataagta tgtgcagtga tggatgttga ttaaattgat ttaataattt taattatttc 78600
acaatatata caaatatcaa aataccatgt tgtataccat aaatatataa tatttgtcaa 78660
ttctgcctta ataaagctgg gagaaaaaaa ctggaaaccc aaatatcctt caacaggtga 78720
atggataaac tgtgggacat ccatacaatg gaatactatc tagcaataaa catgggacaa 78780
agtattgata gatgcaacaa cttggatgga gctcaagggc atatgctgcg tgacagatgt 78840
cagtctcaca agcttacaca ctgtaagagt ccagttctat acaacattct taaaagacaa 78900
atttatagtg atggagaatg ggttagtggt tcctaggagt taggttgggg aagcgtgtca 78960
ctataaagga tagcatgaga gagttgtgtt tataagtgtg tatgtgtgat ggaacagttc 79020
actatcctga ttatgatggt ggtttcgtgt ggtgaatttc atagaaatct atatatgtga 79080
taaatttcat aggactacac acacacacac acaaagtgca cataaaaact ggtgaaattt 79140
aaatagagcc tgtagtttat ataatagtat tgcactaatg tcaatttcct gattttgatc 79200
atgaactctg gttatgtacg atgttattgg ggaaagctgg gcgaaggata cacaggaact 79260
ctctgtactg tttttgcaac ctcttgtgag tcttaaataa tttcaaaatg aaaagctttt 79320
gagaaaaata aagcacaggg atttctgaca aaagctaaat tagaaagcac tgcttgacat 79380
aatgctaaaa caggacccag gaagtggaga gctcactgcc tggtggaggt gggaaagggg 79440
taaagggaag tggagattct tgccttgaag aacatttggt agaacgtggg ccaggcctct 79500
caaacaggtc actcctggct tggggaggag ctaatactaa ggtggaaagg gaaatgaaag 79560
cttacttctc atcagcttcc catatgggga agggggccgg aatctctcct caataggcct 79620
ccattttctc aatagggaaa acggagagaa ggggaaaagg gttcctcttt aacaatggtc 79680
acaaaaggtg atgtgtgcag tgaaagatta aatggtataa gaactcaggc tctggaatca 79740
aacccagcct caaatccagt ggcttgattt tctattgaac tttgctatac cctgtttctc 79800
tatttaaaaa caggggtaat gatactactt aactctgaaa gctgattaca ttagattgtc 79860
tatgtagagc acttagcaac cacctagcac atagataatc agtgttggct actcttttta 79920
atactattct atgccattac caattttcta agacgtaaca ataatacact cagatgattc 79980
tgaccataat gtaatttttg attaaagttt cttcaggatc cttcaatgct tccaactcat 80040
aaattatatc agccctcagt ccctatatat gtaaatacaa tttaaattaa aatagttgtt 80100
actttctatt acatgtcttt tatgtgcttt gcactttaaa tacactattt ctaaccttta 80160
tagcatgcag gataaatact attttcccca ttttcagatg aggaaactgc ttcagagtgg 80220
ttaggcaaat ctccaacatc tataaacaac acagtaaacc taggcagtct gatggcaaag 80280
cccaagctct ttccactaca ctgttacctc agtagtaatc cataaaagat gcttaaacac 80340
atacatattg tctattagtt gttcttttta catcacatta catgggcaga ctctacaact 80400
cctgccacag cctggcgcag acacttccag gccattgctg aagccagtgg agacaccaga 80460
cgatgacaga aaccaagaac ccaaagctga ttgtagcaag aattcagtct ggagttcagt 80520
cagtagataa atccgagagg catcatggaa attgtgccaa ggtccaaggt tcaagccagc 80580
agtcagaatc taaaggggca ggcaaaaccc agcaggaggc tctgcaggct ctgtgccccc 80640
cgggagattc atggcttcct ctctgtctcc tcttgttgac actgccggct ataaatgggg 80700
gctttgtgga tcctcagttg aggaggcagg tgaaaattct tggcctacca gcactactac 80760
aggacgttag aaactagggc aggaagaccc tgggtcttca ttaatcagtg tgatgaaaac 80820
aggccccagg cagttgggtc cactagtggg aagtgaaaga acactgaagg aaaccaggag 80880
tcaggacatc tggatttgct gtcccaacat ggtccctatc tggcgataaa acagcatgca 80940
aatttcttca tctaaaaatg aaggaatcag gtcagatcac tgattttcaa actgtgttcc 81000
tcagaaccca aggactccag tcctgctgtg gagagatagg tgggagcaag caaggccttc 81060
ctgtacagca cgcttccttt catctcttcc aagtactgaa ccttctaatt ctaatgattt 81120
attcagcgta acaggcattt aataagtttc tactaggctc ggggccttgt agaaggtgct 81180
gatggggaca aagctgagta aaacccagtc ccaacatcat gaattcctag attctggctt 81240
aatggggaac cattccagca gctgtcactg ttcaggattc ctctcagatt ccaagataca 81300
ccaaggcccg gagttctgcc acagaattga agataagaaa gagaggaaag aggccgagtg 81360
cagtggctca tgcctgtaat ctcaccactt tcggaggccg aggcaggcgg atcacctggg 81420
gtcaggagtt tgagaccagc ctgaccaaca tggagaaacc ctatctctac taaaaataca 81480
aaataaattg ggcatagtgg tgcacacctg taatctcagc tactcgggag actgaggcag 81540
gagaatcgct tgaacctggg aggtggaggt tgcggcgagc cgagatcgcg ccaccgcact 81600
ccagcctggg caacaagagc gaaactccgt ctcaaaaaaa aaagaggaaa gaggaatctt 81660
ccccagtatg gcaggcaatc tttcctgcct caaggagatc aatttacatg tcacctggaa 81720
gcccataata ttctgcttta gcagtgactc cttgtgattg gatgtttcct atggccaatt 81780
gtgcctgtgc ttcatgccct acttaaaatc aggacatctg ctctgccctt ttggaagagc 81840
tacaagtctc ctgccaggaa ttgctcaagg ccttttcctg cagctaaacg gagaaaggaa 81900
gttgaaatca ttgcctcata aattacaaca catgccaggg ttgtaaccta gagtctgagg 81960
ttctaggcga aaagaggatt ttgtgtgtgt gtctagtgtt ttccccacag catttaaaag 82020
ctcatctaaa atatattata attgcatgag atatggcaaa aatacattca gaaactaatt 82080
ttttgaagat aaacaaacaa agcagaatgt gcccataata ttcctaagta aagccacaca 82140
aacttccttt ccagtaaggg tatcctttgg ggctttttcc ccctccttgt caccaactta 82200
tcttgaattt atcactatgc tttttcacta ttgttcctaa acttcagctg ttatataatg 82260
agatagtggg catttagtct tatatccaaa tttccatatt tcagctttta aaatagttgc 82320
aaggatgctt ttaaagttga tcctggccag gagaggtggc tcactcctgt aatcccaact 82380
ctttgggagg ccaagatggg aggattgctt gagtccagga gtttgagacc agcctgggta 82440
acaatgagac cttgtctctg caaaaaaata aaaattaact gggtgtgatg gcatgcactt 82500
gtagtgccag ctacttggga agctgaggtg ggaggattgc ttgagcccag tagataaatg 82560
ttgcagtaag ccaagatcat gccagtacac tccagcctag attagagagt gaaactctgt 82620
ctcagaaatt aaattaaatt aaattaaaaa gttgatccta gcaaactaac accggaacag 82680
aaaacccaac accgcatgtt ctcactcata agtgggagtt gaacaatgag aacacatggt 82740
cacagagagg ggaacatcgc acaccgaggc ctgttggggg ttgggggcaa ggggagggag 82800
agcattagga caaatactta atgcatgtgg ggcttaaaac ctagatgatg ggttgatagg 82860
tgcagcaaac caccatggca catgtataac tatgtaacaa acctgcacat tctgcctatg 82920
tatcccagaa cttaaagtaa aataaaaaaa gaaagaaaaa aaaagttgat ccttaggcct 82980
gtttatagtc caagggagct gtgaatgctg aaatttgtac actgtcaatt tatatgtata 83040
ttcacatatt aatatctata gtacacatag attcaggaat gtagactttt gtcaaatggc 83100
ctagtagata ctgataaaac aacttctaat attaaattaa aattttattc tattttaaag 83160
aaaaagaaca aataagaaaa tcgtctttgc aatgaaaagg tcagaaacca aggatgtggt 83220
gtcctaatat gctgatagca gagattatat ctcctttgcc ttcctatcac tggttcttaa 83280
taccttggca agttagtatt taggaattgt tgaattaatg tttggcacat gaagatcatt 83340
aaagcaataa ctcataaagc atggggaaaa caaggtcatt tgctaaaggg gaatttgggg 83400
gcacgatatt tagcaagtct tctttcacac ttatagctaa atattttgtt tatttgatta 83460
tttgattgat ttgggtgtaa attctattgc acctctggta aaccaagtca gcctgccctt 83520
cctggttaag aaagagagac agaaatgcaa agtgtaacca gcttattaat aagccgagga 83580
tagagaaaag aaatttgtct ctgggctggg agcagtggct catgcctgta atcctagcac 83640
tttgtgaggc cgaggcaggc gggtcacttg agcccaggag tttgagatca gcctgttcaa 83700
catggtgaaa ccccatctct actaaaatta caaatattag gcaaggatgg tggcatgtgc 83760
ctgtaatccc agctacttgg ggtggctgag acacgagaat cgcttgaacc cgggaggtgg 83820
aggttgcagt gagctgagat cgcctcactg cactccagcc tggctgcact ctagcctggg 83880
caacagagtg agactttgtc taaaaaaaaa caaaaaacaa ctgtctctgg cataacttga 83940
gaagggagaa gctagaagag acctttggtt tcatcaggtc caagcactgc taaccattca 84000
gctattctgt gggcagaatg tctttgttct tccaggtgca acttcagcag ctgtgggcct 84060
gaactgacag tgcggggtaa ggatatcact ctctccatgt gaaacaaagc aggactacag 84120
gaaagcaggc tgatttggaa aggccaggcc cacccaggac aagaggcagt gctgagtgtt 84180
tggctcatga caaaacataa tttacaaatt tactggcttc aaggatgtaa aaagttataa 84240
tttactggct tcaagggtgt aaaaaggcct gcttcctagc ctagctgcaa gcagcaactc 84300
agtccatgat cagcagattt tctgaagcct gggggtggga tgcatgttgt taacctctga 84360
tgcagatgtc tgctgagagt ctgtaatctg tgtggtcatg aagatgagat ttcatccatc 84420
aattgcttga caagggctat catcgtatct ctgggcctgc gtggctctca acacacgacg 84480
taagaaacat attggacaaa agcatttcct gggagaattc tccagcaaga attcagccat 84540
tggcaaagaa tctttcaagt ggccctatct cactggagac aagtaaacat atacgcagtg 84600
catatgtgaa tatacactcc ttcaaggtgc tgcactttcc tagaaacaaa aagaatgaga 84660
ggaaaaagct ttacaggcat cctgttagga tgctttctct cgtttatttt taggctcttt 84720
tcagctctgt gctaagaggg gaggcaaagg aagggcttac ccagaatgca aagcttttta 84780
gtgagggttt ggggtgtgca aatttgttaa agtggtgaaa acccagtgtc tatggaagtt 84840
cacagcatcc acagcactca gagcccccca aatatctctg gcccttgtgt tcactaattc 84900
caaggaattc tcagccattc caggggactg tggggatccc cctgaaacca ctacaattac 84960
ccagaatgtg cccctcctaa cacataggca ttgaaccagt tcctaactct cccccaactc 85020
tcacagatct ctagtacttt aagagccata tggcacacat gcttagccct cagccttctg 85080
cctaataggg gagtgctttg ccagggaaaa ataagattag ggaagaggac aaagaaagaa 85140
gaagagaagg agtttccata tccattaatg aattcattca acagatggtt atggaacact 85200
taccattttc caaagaccgt actatggtgt gggttataga ataagaaaca gcctggcttt 85260
tgaggagtag aaactgtccg gtggaactaa cattaaaagg tggtaatata acatgacaat 85320
tgtactgatg cacatagacc ctggggtgtt ttagggacat agaggatggc accaaaccta 85380
gactgagggc atcatccaga cagatacatg ctcttgtttc tgtgagtcct gtgaggtgag 85440
tcactcacaa agaaaatgta aagaaataac tcagaataaa taaaaagata gatggcacag 85500
taagcttggc agattgatgt tggagaacgt cagttttggt ggcaacaatc tgcaaggttg 85560
tctaattttc tcctgcacca ctcggctgcc cggatgcaaa agcagacaat ggattgtggc 85620
tctgatctga gttttattgg gcagatgctg cagaagggct tgtttgaaaa gggaatagga 85680
tgttattgag agaacagttc agatgaccaa ccagggatct gaaattaggt agagacagta 85740
agagagactg ataaactatg aggaagcaaa agaaccaagt gactggaggt ctataggctg 85800
tcaatgtaca aatgtggcag gagtaagcac atgagagggc tggaggatag gatgctcact 85860
catttattcc tcagatgttt attgagtgcc ttcagtgtcc aggtagtgtt ctagttctga 85920
gagtacatca tgcacaatgc tattgggagg agaaaacaat aaataaaatc ataataataa 85980
acaagtaaat tatgtaatat gttaaaaggt aataagtact atggttggat gggggcaggg 86040
gaagagaata gagcagaata agaattcaga attccgagga tagggtataa ttttaaatag 86100
ggttgtcatc atagctctgg ttgagaaggt aacatatgaa cacacaatca ggagagaaag 86160
aggatgagct atgcagatac atgtattgaa atattccagg cagagagaac agccacttca 86220
aagcctcgca gtgtgtgagt gcctggtgtt ttcaaggaaa agcaaggagg ctgtgtggct 86280
ggagtggagt gggcctggag aagatgtaag aaatgaggtc aagaaacaac agggatcgag 86340
tgtgtaggct ttgtagactc tggtaaagac tggctttccc tctgggaaat agagagtcat 86400
tgtggggttt tgagcacaga agtgatgtga tcttatgtct ctttaatgga ttactctagc 86460
tgctatgttg aaaatagact tgagggaagt gccagggtag aagcagggag accagttagg 86520
aggctattgc aataatccaa ataagaaatg caaagtaaga ctttgatcag gtggtggcag 86580
cagaggtggt gagaaggagt tagattctgg atgtatttcg aggatagagc caacaagatt 86640
tatgacagat tggatgtggg tagtgagcaa gagtcaggat gactccaagg tttttggtcc 86700
aggcaaattg aaaggtggag ttgccattat ctgaaatggg gaagaaggtg agcaattgag 86760
agggagactt ggagttaaat tttgaacaga ttgtagtcaa attggtgttg ggatattggt 86820
gtttacaatt cctgaagggg aaccattctg agtgacccta agacccagag tgtaacctgg 86880
ggatgggtgt ctgaagagga ataaagtgaa atcattatga ttgaataatt tagaactctg 86940
gaggctgaaa agctaatgaa atctcctagg atgttctacg aggatggtgg cccaggcacg 87000
agagtaggga acggggtcag gccttatgat ggatacttta aatacaaata gttagaggtc 87060
acactaatat tagcttgagg tgtgcagaat tttaattggg tgcagattag tgtatacatt 87120
agaaataagc aagatattaa aagatcaaat ttgctgaaac acatcagata acattatgat 87180
aaaggtattt ggagttttat ttgagttaga tttacaatcc cattgtagca tggatcaaaa 87240
acagtaagtt gataaagaaa tcagataaat tttcacaatt taaattttaa ttgttttatt 87300
aaaaagcatt ttggaaagac attcatattt ggttttggat aggttaaagc tcagtgatac 87360
catttacatc aatttttata gcattttaga gagcatggtc ttgtgacatc ttaggataag 87420
ttttctgtta gtcacagcat gccaacaagt accttgtgct ccattctctg gccatgtttt 87480
cagactcagt aacttcaaat aaaataaact gccaagttga gaaattaaca tttgataaag 87540
tttttgcaac atcataccat tgagctggtg gatgtggctt aagcatctga attcattaga 87600
gactattgaa atgataatgc agaattatac aggttttgca gatgtagttc aatatttatc 87660
tatatgtatt gaaacctcac ttgaggatag aaaaatcaag caagttcttg tcttacattt 87720
ccactcaata aatgaagagg aagagataat gagaaagcta tataatcctt taaaaaaaaa 87780
attcaccttg tttctgactg acagtaaccc aattcaggct ttttactctt cataaatgga 87840
agacaagtaa cctagatagt actggctatc tataattaaa tatacaatat tgaaatctat 87900
ttgctttgtg gaaattatgt gtttgtggct gattaaaata ttcagctatg taggcttcat 87960
cttttagctc aatagaaaaa tataaatgac attggtgact gaattcctac caacgtggca 88020
aagacattcc ccagacatac ataattcacc tgctgaattg gagatgattc acctttcagt 88080
gacttcacag gtgttaactt ggccaaacaa aaaagggaaa tcatcttgta ttcatctttt 88140
gttccctgag gcaagttttc agtaagattg ctcgggaaaa atatcacaat atacatatat 88200
aagtccatag tatgtctatt tgaataatga attagcacca ctgtctgaga ggtgaaaact 88260
attcaatgta tattttctgg aaaataacta aattgagttc ctcttaacta aatcagaaag 88320
agaaggaatc ctcaatcagg atttcatgta gtactgtatc actcaaagga aaactgattg 88380
tatagtggta ctcaaataaa gtgggtccaa agaaaaatta tgagagaaac gtaccgatca 88440
gtgatctgga ccaaacagac atgtggctgt gaaatccagg cagttgcttg gtgacgaggt 88500
caccatcaga tagtcatggc ttatgtgcag gaatgtgaga atggccatgg ggaggaatgg 88560
cctgggttat gggtcttgca ggagtcccac tgcttgtgcc attgctcaaa cttctgactg 88620
ccctgtgcag ccggtgccag gtcagcagta ctctctgctc tgaatcagtg tcagcactgg 88680
tctctctaat gtagtacctt tcttcaaaaa atgctttgtg aagctgctgg ttagcactgt 88740
tcttacttct gtagttaata ttcaccacat attccccttc ttttgtggag agataaagaa 88800
attaaggaaa atcactctcc ataagtccac aatctgaaga catggaggct gaggaggcag 88860
acctgaatga ataagtggat catatgatag ggctagatct taaatttgga tacaggagac 88920
ttaaggtaaa ccacagaagc ttgttgttta tacatgtagc tcttttgcta aatataaatg 88980
tggcatgtga agattaataa atctgaatgt aatgtacaga atgtactaga acaggaaaaa 89040
attggtgttt actgagagct gaaggttaca tcaaaaatct aaaaagtaat atttttgcat 89100
catcttaaag tttgcaaaca gttttggcac atacatcatc tcatctttgc aataacctgt 89160
ggggtagata caaaagatga tgttattttc attttccaga tgaggaaata ggagcctgtt 89220
tcctggtcag acaggcttag tcagctgtga gtggcagagc tggtgttccc acctgttacc 89280
ctcaacccca gttccattgc tcctaacatg attgtatcct ggataaacat ggtatcaaga 89340
atggagaggc caagcgcggt ggctcacacc ggttatccca acactgtggg aggccgaggt 89400
gggcggatca cctgaggtca ggagttcgag accagcctgg ccaacatggt gaaaccccat 89460
ctctactaaa aatgcaaaaa ttagatgggt gtggtggtgc gtgcctgtaa acccagctac 89520
tggggagact gaggcatgag aatcacttga acctaggagg tggaggttgc agtgagccga 89580
gattgcccca ctgcactcca tcctgcacaa tagaacaaga cactgtctca aaaaaaaaaa 89640
aaaaatggag agtgaaattt gggaggctga ggcaggcaga tcacttgagg tcaggagttt 89700
gagaccagcc tggccatcat ggcaaaagcc tctctctact aaaaatacaa aaatcagcct 89760
ggcgtggtgg tgggcacctg taatcccagc tgctcggggc tgaagcagaa gaattgcttg 89820
aacctaggag gcagaggttg cagtgagcca agatcatacc actacactcc aacctgagca 89880
acagagagag actctgtctc aaaaaaaaaa aaggatggag agtgagagaa aactcagaga 89940
ctttgaaata agaagtgaaa gaggccgggc acagtggctc acacctgtaa tcccagcacc 90000
ttgggagacc gaggcaggca gatcatttga ggtcaggagt gcgagaccag cctggccaac 90060
atggtgaaac ctgtctctac taaaaacaca aaaattagct gggcatggtg gcgggcacct 90120
gtaatcccag ctactcggga ggctgaggca ggagaatcac ttgaaccagg gaggcagagg 90180
ttgtggtgag ccaagatcat gccattgcac ttcagcctgg gtgacagagc aagactctgt 90240
ctcaaaaaaa ttaaaaaaag aagaagaaat gaaagaaact tggcaattga ttgggtgttt 90300
ctgataaaga aacagaagaa ggaaaaggtg attcctaggt ttctaaaacc tggaagaggt 90360
ggacagtgag attataatat aagcagctga tgttggcaac atgcctacta tgtgccaggc 90420
catgtgccaa gcattttgcc atattgcctt attaaatcct tacaactctt tgaaggtaga 90480
tcgcataatt attattctca ttttagaaaa gggtgtgcat gaaagttgct ctcactttta 90540
gaaaaagaaa aaaatcttcc ctccaaaaca aggctaagct caactggatt cactggccta 90600
tgctgacagt acctggggcc tgggacagtg gtttggtgtt cttgtgtgta tggatgtatt 90660
acaatgtcag acacaaagta actaagccgt gctcctggcg gttatgatgc ttgcaaatcc 90720
agcactgcca aactgtttag tgcctcctag gtgctttgcc tgtggttaga acaagcttca 90780
ctaagtggat agttttgcct tggccctgcc tttaaggcag tctgccatgt catcaagaga 90840
cataggtaag aatgctctcc tccttagtta tgatttaaaa ataaaagtat aacaaagtat 90900
aattatcaaa tgactattag tagaaatgtt gcatttatat acactattta gattacaatt 90960
cttaaataca atgtctttcc ttcttgttac ttgtaattaa ttagtatcag tcactgtcca 91020
gtgtgagcct ggcattgccc ttaggttaac cagttcacat cctgaacttc tgttggtgcc 91080
cagggtattt gtctgaaacc ctgattattt acatctccct ctaactttca aatttgtctc 91140
caatctcatc taaaactatt aatacttgag aaaaggcctt tccccaattt cctgcttcta 91200
atccctttat cctctttctt tcttggaaaa gtagaggaaa atggtttaca tatcaaataa 91260
agtaaatagt atatgaaaaa aaaaaaacct ctaagggctc caaactctgt ggatatctac 91320
ctgctggtta tttattcact aagctgcaca tagcaatccc ctagcaacca taaacttcat 91380
gcataaaatc ccaactcttc tccaatacca cctgtttgta ggtagtcatc cttcttttaa 91440
aagacttggg agttatacaa ggaataagtg ccagagttta gttctttgtg aaaataaatt 91500
taaagaaatt ataagttttc acagggctgt aaagatgttt cttcccagtg gtccttcact 91560
ccaaggctgc actggagatt atgctggtga ggaagctttg gtctcgtagg tctttggccc 91620
caaggcaaaa ggtcatggct gtaagtgtct ttcttcctga tcccctctag gattgtgaag 91680
atgtccagtc ccaatctgaa cattgtgacc ttactgggca gttgtctcac ttacagtagc 91740
gcttacctct ttgggattca ggatgtttta gtggggagct caatggaaac tctcattcag 91800
gtaggtgaag ttttaaaatt tggttttgac tataaagttt tgattatttt tttaaaccag 91860
ctgctcccgt gggtggtggt ttcctttatc cttggagtgg gcacttttcg agggaatccc 91920
agaacacttg gtgaggttca ctctgtacct cgtgcgctct gtgggaccca gaccctacag 91980
atcagagtgt gtggagaact gataaaggtt cctcttgtga ctcttctgtc cccttccacc 92040
catagacaag actgtccatg ctgtgcattg ggacctccct tgtgtttggc cccattctgg 92100
gaaagagctg gcgactctac aaggtgttta cccaaagggt cccggacaag agagtggtga 92160
gtaggcagca agtacacaat gcttgactgt agatggtagc ttcagcattg gttaacagct 92220
agagaagctc atgcacatta ctgagcctag cccctttcag gacatccaaa gttcctgttt 92280
ctcattccaa accctggaat catgcagcct cataaggcct caggtctgga aggctgtgga 92340
tcagtgctgt tgaagatagg gcttcaaacg tgggctctgg ttcctatgta ccccaggccc 92400
tgtggggaca tgtgagctgg ccaatacctg gcaccagtgt gaggcagaac aagataccca 92460
gagactgttg tttggcacag gtgcgagctg gaagtgaagg gaggaagagt gattacagag 92520
aaactatagc aagtaagtag ttatttcctt ccctggagtc cagttctttt ctatgtagaa 92580
ggcagttctc tgtactgaga aggatgtgcc caaagcagtg agcaaggaag agcagataga 92640
atcaactcta agttatgtag cagccagatc accgacatgt ccctggtatc agtcatcaac 92700
ttaaccacat ttccccattt tatcaggttg tctgatgaga ctgctcaaac ctcaattcct 92760
gaccattatc ctcattgggt ataggccctg cccagaccca atatatcatt cagttggtgt 92820
ttacttctct ggaatgatgg gaatttattt tagcaaatgt tattgaatca tggtgcatac 92880
ttaccaaaag ctcagctgtg agcaaccata cctatgaaga agattgccta aaaggacaaa 92940
aactgcattc atccctcaag aacaccaatt tcttttttaa acagctttac tgaagtataa 93000
ctgacatgca gtgaactgca catatttaaa gcatatgatt tgataaattg tgacatggat 93060
atacaaccaa gaaacatggt gcataatgaa catatccctc atcttcaaaa gcttccttgc 93120
aaccctttgt tatctccctc ccctgtccaa tccttatatc ccttgttcct atcctcagaa 93180
aatcattgat ttgctgtcac tgtagatgag tttgcatttt ccagagtttt acataaatgg 93240
aaccatgcag tatggactct gttttctctg gcttatttta ctcacataat tgtttttatg 93300
aatattatag ttatttatct atgttgtgtg catcaatagt tatttctttg ttattgctga 93360
gtagtattac aatgcataga cacaatttgc ttatctgtag atggatgttt gggttatcgc 93420
cagttgtggc gattaaaatt aaagctgcta tgaacattcg tgtacaaagt ctttgtttag 93480
acataggctt ttatttctct tgggtgaaaa cctaagagta tggttggatc atatggtaag 93540
tgtatattta actttttaag taacagtcag actgtttttc gaagtggttg taccattctg 93600
catttccacc agcaatgtat gagagtccat ttcctccaca ttcttggcaa catttgattt 93660
gatcagtctt tttcatttta ggcattctaa taggtatgtg tggtagtatc tcattatgct 93720
ttcaaatttg catttctcta atgcagtatt gagcatttct tcacttgctt atttgccatc 93780
catacacctt ctttggcaaa ctttctgttc aaatcttcca cccatttttt ttttttttct 93840
gagacagagt ttcattcttt cgcccaggcc ggagtgcagt ggtgtgatct tggctcactg 93900
caacctctgc cttctgcttt ccagcaattc tcctgcctca gcctcccaag tagctgggat 93960
tacaggcacc caccagcaca cccggctaat ttttgtattt ttagtagaga tggggtttca 94020
tcatgttgac caggctggtc tcgaactcct gacctcgtga tccgcctacc ttggcctccc 94080
aaagtgctgg gattataggc atgagccacc acacccagcc tcactcattt ttaaattgga 94140
ttttttgttg tcttattatt gagttttgtg agttcttttt atattctgga tacaaaccct 94200
ttatcagatg tatgatttgc aaagattttc ttccagtttg ttcttttgtt ccttttactt 94260
tcatttactt cagaatgtct ttcaaagata agacatttct cattctgatg aagttgaatt 94320
taccaatgtg ttctttgttt ttaggtttct tgtttatttg tttgtttgtt tttgtatttt 94380
tagtagagac ggggctttac catgttggcc aggctggtct caaactcctg gcctcaagtg 94440
attcaccagc ctcagcctcc caaagttcca ggattacagg catgagccac cacacccggc 94500
cccaatgtgt tcttttatgg atcatgtttt tggtattata tttaagaaat ttttgcctaa 94560
cttaaggccc caaaaggttt tctcatgtgt ttacttccag aaattttaga gttttagctt 94620
tgacatttag gcctatgatc ggtatatggt atgatgtatt gattgaattt tagtttttta 94680
catatagaca tttgattatt ccaacatcat ttgttgaaaa gattgtcctt tcttcactga 94740
attacctttg tgcctttgtt aaatcagttg tccataagtg tgtagatcta tttctggacc 94800
ctccattctg tctcactgat gtgtctatct caacagcaat gccatattac cctgattact 94860
gtagctttat actaaatctt gaaatcaggt agtattagtt ctttgacttt cttcttctct 94920
ttcaatgctg ttttggctaa tctgggtcct ttgaatgccc atgtgaattt ttgaatcagt 94980
tcactgattt ctacaaaaat tcttttggga ttatgttgaa tctaatagat caaattatgg 95040
agaattggct tcttactaat gttgtgtcct ttgacccatg aacccattta tttaggtctt 95100
taatttttcc catcattttt ttgtactttt caatattgct ctttcacatc tttcatcaaa 95160
cttatttcta gggattttat atttttatgc tattttatat gttactattt ttttaaattt 95220
cactttccag ttgtttgttg ctaataaata gaaatataat tattattatt attttttttt 95280
gagatggagt ctcactctgt cgcttaggct ggagtgcagt ggtgcgatct cggcttaccg 95340
caacctccgc ctcccgggtt caagcaattc tcctacctca gcctcccaag tagctaggat 95400
tacaggtgcc tgctaccaca cctggttagt ttttgtattt ttagtagaga tgaggtttta 95460
ccgttttggc caggttggtc tcaaactccc aacctcagat gatctgcctt ccttggcctc 95520
ccgaagttct gggattacag gcattagcca ccatgcctgg ccacagaaat ataattaatt 95580
tttatatgct tagcttgtat actgcaacct tgctaaacta catgttagtt ctagcagctt 95640
ttttatagag tctatcagat tttctacaaa gatgatcata tcagcagtga ataaagataa 95700
tttatttcca atctcttgtc tgattgcact ggctagatac aatagtacaa tctgaataga 95760
agtggtgaga gcagatatat ttgttattct tgatcctatg gggaaaacag tcaaaactaa 95820
gaatgatatt agcagtagtt ttattgtaaa ttccatttat ccagttgggg cagtactatt 95880
ctattcttat tttgctgaga gttttaatca agaactgatg ttgggttttg tcaaaagctt 95940
tttctgggtc tattgagatg atcatacagt ttttcttttc ttagtttatt cgcatggtgg 96000
attatgttaa atggtttttt ttttaaaccc ttacacaata gactttattt tttagagtag 96060
ttttaagtta acataaaaat tgagcagaag gtacagaggt tttacatata cagtctttcc 96120
ccacacatgc atagcctctc ccattatcaa tattccccat cagagtatat acttattaca 96180
attgatggaa ctacattaat acgtcattat cacccagagt ctgtacttga cattagggtt 96240
cacttttggt gttgtacatt ttatgggtct ggacaaatgt gcaatgacat gtatctacca 96300
ttacagtatc atacagagta gttttactgc cctaaaaatc ctctatgctt ctgctcatta 96360
tctctttctc tccccatatg ttaaatgatt tagggtgtca aaccaacctt ccatccctgg 96420
gattagcttc atttggtcat gctacattat cctcttcata tattgttgga ctcagtttta 96480
taaaaacttt gtttagaatt tgtacattca tgtttttaat acatattgct ctgtggttgc 96540
cttgtaatat atttttctag ttttggtatc agggtaatgt tggctttata aaatgagttg 96600
ggaactattc ccttcttttc aatttcagga ataatttcta tagaatagca taattggcac 96660
tcatgtataa gtaccttaca atagtatgct tccttttatc cccattccta tctttgctgt 96720
tacatgttat aggccccatg caattctttt gtttaataaa tcaattatct ttaaaaatat 96780
tttatttttt tatttttaag acccaggaca acatgctgaa ttttgttatt ttctttaatg 96840
atatttaaat aatgaaaact aatcatgtat ttttctgttt agttaccatt tccagtgttc 96900
ttaatttcct gtatagatcc acatttttat ctcatattat tttcctttgc ctgaaggata 96960
tctaacattc cagtgtgggt gtgctactac tgaattcttt cagcttttga ttatctgaaa 97020
aagtctttat tttgccttca tttctgaaag atatattact gagtatagaa ttctagactg 97080
aaattttctt ttcttcttct agtactttca agatgttcct gcactgtctt ctcacttggc 97140
cttgtatctg atgagaagtg tcaggtttat tttatgtcta cacaaaatgt gtctttcttc 97200
actgcttgct ttgagtagtt tccctttatc actggttttg aacagtttga ttaggcaatt 97260
ggtttgtttt taattttaca aacaccttga atcacgtaac tggttgtgct tcttttcact 97320
ggttgtcaaa agctcagatc cacatttctt ctgctccaat tagtaaatgc tattatatat 97380
acactcttca tctgagcctt catcataatt ccctttattt tctctcttcc cggttgttaa 97440
atattttaat cctatcacag tatatatttt tctcaatttt atttttgtag tcacaaacta 97500
acacattctc ttcatcctaa gtcaaatacg gatggtccct gacataaaac agttcaactt 97560
acagtttttc tattttacaa tggtgtgaaa gcaatccaca ttcagtagaa accatactta 97620
aaatacccat acaaccactc tgtttttcac tttcagcaca gtagtcaata cattttatga 97680
gatattcaac acttcattat aaattaaatt aagctttgtt ttagatgatt ttgcccaggt 97740
gtaggctaat ataagtgttc tgagcacatt aaaggtaggc taggttaagc tgcaatgttt 97800
ggtagcctag gtgtattaaa tgcatttttg acttatgata ttttcaactt atgatgggtt 97860
tatccggaca taaccccatc ataagtcaag atcataagtc aatctgtaat tcatatgtat 97920
ataatgaaaa tgctaatgat tcttcctgca tctctgagtc ccaccctctc agttaatagt 97980
tattaacatt gtggtgtgac attcatatct atgtgcttat ataaacatat agaaataata 98040
gtttatttat tttataaaac accttgagtc ctttgtggga aaaggtagga tatgaagaag 98100
ttaaacaaat ggaaatgtgt aatgctaata atgatatcag catagaagtc attgtaaatg 98160
tttggtgtct gtttcatttt tgatagctac atttgaagct ccttgggagg gctgaccttg 98220
gagcatatag ctgagagcac atgggatact ctagcccctc tgtcatttag ccagtcaaca 98280
aggagaagtt ttgaccttga ctcttttgca gattatcaaa gacctgcagt tgctggggtt 98340
ggtggcagcc ctgttgatgg ctgatgtgat cctgctcatg acgtgggtgc tgactgatcc 98400
catccagtgc ctccagattc tcagtgtgag gggccaaatc cctagagaat ctcatcccca 98460
aactggactg acctctgtgg atacacagga gtcatccttg caacaagaag ataaaggact 98520
ccaagaggag ggagagtcag gagttgtggc ttccatgtaa ttcttgccct agtctgctgc 98580
cactcccact gctcctcctg cccgagtgtc tctttgtggg catacaatga gatatcagca 98640
tgctggaatc tgcctggcag ttctgccact tccacattat caataattaa aactttcagc 98700
tatcggcagt taccttcccc taattgtaga ggtggaggta gtagtttaag gtggcctttg 98760
gagtcagtca accctggttc aaatcccagc tctaccaagc tcaccagttg tgtgaccttg 98820
ggaaagttat gtaacctctc taagtctgtt tcctaattgg taaaattgag ataataatac 98880
tacctatctc atagggttgt ggcaaagatt aaatgaaaca atgtaggtaa aagacttaac 98940
catgtccagt acatactatt caattaacaa gaagtatggc cgggcacggt ggctcacgcc 99000
tgtaatccca gcattttggg aggctgaggc aggtagctca cttgaggtga ggagtttgag 99060
accagcctgg ccaacatgat gaaaccatgt ctctaccaaa aatacaaaaa ttagccaggc 99120
gtggtggcac atgcctgtaa tcccagctac ttgggaagct gaggcaggag aatctcttga 99180
acccaggaag cagaggttgc agtgagctga gattgcacca ctgcactcca gcctgggtga 99240
cagagtgaga ccctgccaaa aaaaaaaaaa aattattata tatctccagc ctcacgaggg 99300
gctgaggaat acagtggaat catggaatcg tgacactgca agattaatgt ttaaggattc 99360
aatgatttgc aaaaagcagg tgcataatga aatagtttat agttttgttg aggcactaat 99420
ttgattgggg tagcaaagca cataaatgag gggtaagccc tagtgtcacc aagcacacag 99480
ctgttagccc aactttatca tctcttctcc taacacgtag tcactctcat ttaggttcta 99540
gtggagtcac ctaaatgctg cagtttttac atactgaggg ggtatcatgt actctagaag 99600
aattcatgct ccagcatgtt cacaaagatc tgctttgtgt tcctggtaat tgtgggcacc 99660
tccagttctg actctgtgtc ccttctaggt gacagggaaa gacgtgtcct gcacttcgac 99720
cagcacccac ttctgtgctt cccggtattc cgatgtttgg attgctctca tttggggatg 99780
caaggttggt aaccacatct gatatggtct ctgtcaccaa gaaaatggat atgaagaggg 99840
aattacagga attaacgagg tgatgtctgc aaagaatctt gaactcagag gagacctctg 99900
ttgatgcata aacttcaaag ccatgactgt ttttactttt ctatttgtat ttgtttgggg 99960
gagaccctcc aactctttag actccctcat tcagtcctcc cccaaatcat ctggaattca 100020
cccactgttt ctcctattta ttggtctggt ttcttaattg atttgacaat accagttttc 100080
ccttcatctt ccctgcaaga ggaattatga ggagaaattt gacccagctt tatttgttct 100140
cctaagtgcc cttattatgt ctcttgtgtt ttcttcaaga tttgggcgaa ggtgtcctgg 100200
tgcctttcac ccacctgact ttctccctct ggttggaagc aagactggct ctgagacaga 100260
tggcagcatt cacagggccc tttgaggggt tccacctgtc tcacagtgtc tcccatactg 100320
ccccaaatct ctcaccatta gactcatttg tctctgttag atgggcaaaa gtagaatatt 100380
atttccagaa ggtagaggat acctgcatgg agcactgagg atggtcctca gaacaggaca 100440
gctggttttc agcttaggga gacagagaac tggtgctgag gggtacaggg cagtcctgat 100500
tccataaaca agcaagtcct gcctgacagc agactacctg ttgactatca gggcagagag 100560
ttctggttga ctgattactg gcagaggaaa aggaggagtt tttgtagaaa taagtaccct 100620
ttaagggtaa actctggccg ggcacagtgg ctcacacctg taatcccagc actttgggag 100680
gctgaggtgg gtggatcact taaggtcagg agttcgagac cagcctggcc aaacatggtg 100740
aaactctgcc tctactaaaa atatagaaat tagctgggtg tggtggtatg cacctataat 100800
cccagctact tgggaggctt gaggcaggag aatcacttga acctgggagg cagaggttac 100860
agtgagccaa gattgcgcca ctgcactcca tcctgggcaa cagagcgaga ctctatctca 100920
ataaaaaaaa aaaggggggg taaactttac ccacttcacc actaagaaag tattagaagt 100980
tgttgcttgt gaggaacagg tttaggggta ggccagacta gggcagggaa acattccttt 101040
ttaactatgt gcaaatatta ctttgacaga aatatttttt aaaagaagac tctaggaagt 101100
gaacagctct tgatctccag aatcttgcta atggttaaaa aaggagcttt agttgtgaca 101160
gatcagggtt tgaatctgac tccgcccctg gctagccaac cctgagcctc atttaacctc 101220
tctgagcctc agtttccaaa ttttaaaatg cggatgatga taatatcccc tcagaactgt 101280
tctgtctcta aagagttaat gcatgttaag agttttcagc cgctcctggt ccatagcaag 101340
agctcaataa atgttagata ttattattac tattcttcca ctgcccccta gacacttctg 101400
gaaaatacat tgcctctgtt ggttccttga gtccctgtag aagagtgtgt cctccctagc 101460
ccagaaagcc agcacttccc ccatagctac ttactttgtg actcaatttg atttattttc 101520
tccattgcct tttatatact ctcatttcca ttctatttta ctgtaatatc tttctgtagg 101580
aaaaagaagg aaaaggatgg agcatcagga aacttactga gccagacccc atagactccc 101640
tggtcagtga gaagctcctc aggaggaccc caatctccac attgagtcct aggacccctg 101700
ctctctgtca actgccccct accccacact tctcagcagt taaggccagt gatatgcaag 101760
gatcaaatat gactcactca gacaccagcc aggaatgtat agacacttga ttcacaccca 101820
tttccccttt aacaagaatt ttaatggaat taaaaacttt tagtggaatc atatctgaac 101880
atttcaaaat cacagaatta atttcatttg ccttttatta aattagcaat gatccaactc 101940
tgctgaatac cacctgatgg cgtcagttac ccaaaagttg ggcttccctg gtctcctgac 102000
ttatgtgtcc tctagtcatt gaagatctca gggtggccac atttggcctt caggccccat 102060
ttgggacact gggcattagg ggaacctgga aggtatctct tccatgctga ctccttccct 102120
tctggcacag ccagttctcc aaaatatgtt ctttagtgtc acccatgaag gtggagttga 102180
ccacgtcata tgatttgagg gtcaccagca ggtgtcctgc tgatacctga ctttattttc 102240
attattagtt ctccctctga atcccacagt cccaccccca cctcgtctcc catggcatct 102300
tcacgttctg agtcatcaac atgaacattt ttaggctggg cgcagtggct catgccggta 102360
atcccagcac tttgggaggc taaggcggtt ggatcacctg aggtcaggag tttgagacca 102420
gcctgaccaa catggtgaaa ccccatctct actaaaaata caaaattagc tcagcatggt 102480
ggcacaagcc tgtaatccca gctactcggg ggctgagaca ggagaatcgc ttgaacccgg 102540
gagacggagg ttgcagtgag cagagatcat gccattgcac ttcagcctgg gcaacaagag 102600
cgaaactcca tctcaaaaaa aaaaaaaaag aagatttttg tgcttacctt aaatctacct 102660
accagaccaa gtgttaaaag ccaggaccat gacttctttg tgtcactatt ttctgcccta 102720
cacgtactat ggcactgcac acatagtcag aaaggtgaac ctaattgaat ctatgtgtta 102780
tgtattattg actaaagctt tgatttctgt atgaatgcag ctcctgtgga gggggcagca 102840
ctttaaggtg ctatgagtta ttttctcctt agtacaaatg acaactctga gagcaggttt 102900
atattcatag gaaagagaac agaatagggc cctgggttcc ttgtagggga gcaagaaatg 102960
tcacaaaaag ggtgagaact atagatggag ctttcgctgt ctgtgcctgc cccacagtct 103020
tgcctgggtc ccagcctgcc tttgttctcc ccttttttta cccttcatct cccataaaca 103080
ctcactggca tggagccgct gctagcctgt agagatcctt tgtgtaaatt ttttgaaggc 103140
ccatcccttc tagtcagatg cagtcttgca ggtgcaaggc ttggcaagca gatggtgcct 103200
ttgggcaaat tagagaaaag agccccttcc tatgggcact accctggctg tggcacatga 103260
cttgacaagc agatcagagg tcactttcag cttccctgtg caccctcagc tttgagcagg 103320
gcaacaccag acaatggctg tggtagcact cactatcaga ggttctgtgg gcccactgtc 103380
ctccaagtgc ccaacagctc tttctgtagg gatactaacc cacccacatg atcctgtcct 103440
atgccttgtc tcagaagagt cttatttaat ggctgacttg ctgacttctg ataaactaat 103500
tctcagcaaa ggagaggaaa ataacattta ttaagtatct agtaggtata aggggctgcc 103560
ctgagggttt tcttatgtga tatcttagta aatcctcata gcagtcctta aggtaggtat 103620
tattatccta attttacaga tgaggaaatt ggttgcaaac ctactgctca ttgacctctt 103680
gttccacttc tctgagcctc cgtcacctct tcacccccca gggtctgctc ctgctgtatg 103740
gtgcctacct ggctggcctg actggccatg tcagctcccc tcctgtgaat cagtccttaa 103800
ccatcatggt gggggtcaac ctccttgtac tggctgctgg gctgcttttt gtagtcacca 103860
gatacttgca ttcctggccc aacctggtct ttggactcac atctggaggg atctttgttt 103920
gtacaactac aatcaactgc ttcatcttca ttccccaggt atggattttg cagggctggt 103980
cctcttagtc actctagagt ttttcactga caaattgctc attttgtttt ctactgatac 104040
ctttccatgc cacttattgg agagtcagaa agcagacagg ggatcctagt gagctggttg 104100
cctttgtcct ttctcactgt cctggtcagc aagggggaca aggcagagtg gtccaagcag 104160
tggtggcagc ccctgtttgc actcttccac acctgtggtg cctgtccctt gggggggctg 104220
cctcgcagtc ctgcttttcc atccaccctc tggtctgctg cactcgttcc ccatcctccc 104280
ctcatttcca tcatgttatt actatttctt tcactagcct gggagcaagg aacctttata 104340
tttttccaat tggggattgc agactcacag gaaaaaatcc atttagatgg aactttatga 104400
tttaaagtgc tttctctttc tttttattgg aggaaaatac agaacatttc tctgcttttt 104460
acaataagga gaggtagaaa ctaaataaaa atatgtttca tattatgggg attttaaaaa 104520
atcaaatgag ggaggaagac agaagcagaa atagccagat agcaaagaag aaaggtagtc 104580
agagggaaca gagaaggaat cctaggctca gaaagcaagg ggatgtggga ttgttcatgc 104640
tacaccctgg ggaccatcaa gccacatata tctaggttaa tgaacttggc actaggtact 104700
ttcttgtttc cctcctagtt ctccttttct tccctctgag acctccctca tcccactcct 104760
ccttcaagac cctgtcctga ttcccattgc aacttccagt tgactgtaaa ctaattcctc 104820
atgatggagc taactgataa tgtaagtgtt ggctgatggc acgttacagt gtatttgtga 104880
aagggaagag tgcactttgg gtcatgatgg tatgacatgg gcatagccct gttacgattc 104940
ttctctatca caaatcctca ttacagtact caacagaata cataaatatg gaaaaatctg 105000
cagcagcagc actagaaacg atggatggct attgcctctg tgccagaaac tggaggaatt 105060
tttgccaaat cttaatgccg taaaaactgg aatgaaggaa gccatttaga gctgaggctt 105120
gtttgtctgg gatgaggcag aaatgggctc tgagaagcaa ggactgtttc tccctgggag 105180
accgggggcg ggggcggggt gggtgggcag gggtaagggt aggcaggtgc cttttgggaa 105240
gcccacccct taggccctgc agccaatatt gttggattgg tagcgatcaa caatgcagag 105300
aactggtgct gaagggtaca aggcagtcct gattccataa acaagcaagc cctgcctgac 105360
agcagcctac ctgttgactg tcagggcgga gaggcctggt tgactgatta ctggcagagg 105420
aaaaggagga gtttttgtag aaataagtac cctttaaggg taaactctgg ccaggcacag 105480
tggctcacac ctgtaatccc agcacttggt gaggctgagg taggcgtatc acttgaggtt 105540
aggagttcga gaccagcctg gccaacatgg tgaaactctg tctctactaa aaatatgaaa 105600
attagctggg catggtggtg cacgcctata atcccagcta ctcgggaggc tgaggcagga 105660
aaatcacttg aacccgggag gcagaggttg cagtgagccg agattgcgcc actgccctcc 105720
agcctgggca acagagctgc taaccccttt cttccttgct tgcctgcact atagagacag 105780
caacagctag actcttcttt tgccagcttc ccatagagat aggagtgcct atatgacacc 105840
attttgaaca ctagaggttt tctgagaagc ttctgagaaa gcttttgctt tcctgaaaaa 105900
ggttataagc atggctaaca tcaccctttt taccttcttc ctgccttgaa tgtatgtgat 105960
tcctagagct atggcagctc tcttgtgaac ataaggaaaa gactaagaga atatagttat 106020
aatactagga agatacagct ctttccatgt aagattataa attctggagg aaatgatcta 106080
tgaagggaat ctgcagttca caagaagagg actacaaatg tctaaagatt tagagaagct 106140
gccttcctct ggagtagaag tgtttagaag ataccggact tgtcaataga attcaaagga 106200
tattgtctct tctcaactaa agcaaactat catgaaaaaa agctaatctt aataaaatat 106260
tgaataagga ttaaaaatat ggtattaaat ttaaaatccc aatagaagca ttgactgggc 106320
aattagacac tacaaaatat tgaattagtg aattacttta aggaaacaga aaataaggaa 106380
acaaatgaga gactagataa gaaaatatgg aaaatggcca gatgcagtac ctcatgcctg 106440
taatcccagc attttgggag gccgatgtga gcggatcacc tgaggtcagg agttcgaaac 106500
cagcctgacc aacatggtga aaccccatct ctactaaaaa tacaaaaatt agctgggcgt 106560
tgtggcatcc atctgtaatc ccagctacta gggagactga ggcaggagaa tcgcctgaac 106620
ccaggaggca gaggttgcag tgagccaaga tcacgccatt gcactccagc ctgggcaaca 106680
agagcgaaaa tctgtctcaa aaaataaaat aaaaagaaaa aaataaaata tggaaaacat 106740
ctaggaatac aattgagagc tgataggagt ctctgaaaga gaacaaaata atttggggca 106800
gaagtcatta tcaaagagct atcagaggaa aatgtttctg aacaaacaaa gccttggtca 106860
gaaaactgaa tgaattggca atctccatga tggcgccctg cttactgctc ctctctccat 106920
cctcacctct caccactgcc cccttgcatc gtaagcctca gccacatcac ttcccctttg 106980
cctggtgttt gagtcctcag cagctaggac aattgtgaca tctgggtact ctacacacaa 107040
aaatgcagaa tgaagtgctg cttgaaatct gccttccagg ttttcactaa gcaacaaaca 107100
cttgatttgt tgaattggga atggaaatgg aatgattatg aggtacagga attgggtgga 107160
tggactgcac tggccttgct ttccttctat ctcactccct ctttccctcc tagctttctt 107220
aagcttcctt tctcttactc tgtctttcct cttccatttt ctcccttgtg tttttttttt 107280
ttctcctctg gaactaactg accatgatgt gaaactaaaa aatatatttt gtagtctgtt 107340
gtattttagg tttagatggt aagtagttct ttttcaaaat ataaaagaaa ctgaggtttg 107400
ttaggtttct gtgtgtttcc ctctggctcc gaggtctttg gtagaagaac gattctccct 107460
gtgatacttg cactgtgtat tcctagaaga taatttggga aagtaatttg agtaaatttg 107520
ggaaagtggg tgaggggaac tatctgggta agggttgggg gttgcagcaa aacggggttc 107580
cttcttgcca gtgagctttc agacatgact gtgatgggag gagtttgtga aagcaaaggc 107640
acagataccc ccagggcagc gaggcagcgc cagagagcgg gtgaaatgga tgacattact 107700
aaggagacaa ggggcccaag aagccttctt tacacaggca ctcaggaaat gcctgagtgt 107760
ttatgccaag cactgaggtc atcactagaa gtcagccagc cgctgctgtt ctgacctgaa 107820
tatgacccat cccccagccc tctgctccct cagagaggca ggcaggtcct aaggtaggac 107880
attgttttct ctctcctcta accccgaaag catttcatct gctcctccct gaagatgtgc 107940
aggcctttct aatctgcctt ataattatat gtatatgtcc cagcacccct actagaccag 108000
tgagcatttt aaagaaagct tccttcattt gttcatgcat gcatccatcc atccacttat 108060
taactgctgg gtacatgcac ttaaacacag agtccgcctc taggtctagt ggggagcaaa 108120
catgaaagga attatcatac atgtgttaag agctttgaga aaggccttcc ccagcccatc 108180
tgagaactca gtggcacctt ctcagaaaat gaggctgggc atggtggctc atgcttataa 108240
tcccagcact tttcaaggct gaggcgggta gatcgcttga gcccaagagt tcgagagcaa 108300
cctggtcaac atggtgaaac ctggtctctg caaaaaatgc aaaaattggc tagacgtggt 108360
ggctcacgcc tgtaattcca gcagtttggg aggacaaggc gggcagatca cgtgaagtca 108420
ggagtttgag accagcctgg ccaacatggt aaaaccccgt ctctactaaa aatacaaaaa 108480
attagctggg tgtggtggcg ggcgcctgta atccagctac ttgggaggct gaggcaggag 108540
agttgcttaa accgggagac aagggttgca gtgagccgag attgtgccat tgcactccag 108600
ccagagacag agtgagactg tctcaaaaaa tataaagcaa aaattagcca ggcatggtgg 108660
tgcatgcctc tggtcccagc tacccaggag gctgaagtag gaggatcacc tgagcccagg 108720
aggttgaggc tgcagtgagc tgtgattgtg ccactgcact ccagacagag taagaccctg 108780
tctcaaaaaa aaaaaaaaag aaggaaggaa gggagagagg gagggaggga aggagggagg 108840
taggaaggaa ggaaggaagg aagatgaggt gttcgagctc agtcttgaag gaaacataag 108900
agttcattga agagatgggg gaaagtaggt ggcatttctg atggaataac atcatgacca 108960
gaggcaggga ggctagaaag agagtagcgt atgtttggag caccatggtc tttgttattt 109020
ttgaagcaca aatggaaacc agggggagaa tgacaggact ggggagagac acacctgggg 109080
agcttctgag gccctgctgg accctgttaa agagttgaca tttagtccca ccatattagt 109140
ttcccactgc tgctataaca aattcccaca agcttagtgg cttaaaataa tacaagttta 109200
ttatcttaaa attttggagg tcagaaatct gaaataggtc ttatttggct aaacttaagg 109260
tgtcaggaag tctgtattcc ctccagagat gcaaggggag aatctgtttc cttgtctttt 109320
tcagcttcta gaggccgtct gcattcttgt gcttattgtc ccctcctcca ccttctaagc 109380
cagccaggtt caaatctgcc agaagagatt caaatctttc tctctctcgc ccctgtttcc 109440
attgtcacat ctccttctcc aactctggct ctcctccctc cctcctataa ggattcttgt 109500
gattacattg ggcccacttg gataacccag aataatcacc cctcttgaaa tccttaatta 109560
catttgcaaa gtcccttttg ccacataagg tcacatattc acaggctcca ggaattagga 109620
tgagagagaa catctttgag aagccactgt tcagtctgcc acacccccat agcccagagg 109680
ctcagaaaac cagaatctgc ctgtccttct ggaggaaggc agaggagagg ccctgaattg 109740
tgaaattcat agctggattc cagaaaccct gaagggttga gccttaagga gtatcttcac 109800
aaatgaggaa tgaagggcta gagtaatcaa ggggtatctt ggctccactt ggccaattta 109860
gagacaggaa gaccaaaagc cctgggaggg cccttacgcc agtgctgagc tgctcctctg 109920
ccagccctgc agagaggcct cagtctggga gtgctggggg agatgaagga aaagctgtac 109980
tgcagcactg ccagggtcag tgtgaggaga ataaccctag gaggtctgat tcatccaccc 110040
aaggccacag atgaccttgt gttgttggct ccagtagctc ccaagtagga tggtgagctg 110100
agagcatcct ttcgtgggga gggggccttc aagaagggca tctgagaggg gaggtaccag 110160
gcctgaccca acacaggtca cacagactcc tggtgcgatg atggactcat gatgagtcag 110220
cagaggaccc aagaggactt gggtgataat atcaatttca gtggcattga aattgatggc 110280
aggattcaga atcctatctg agatttacaa aatttggttt acactccatg gtcggagctt 110340
aacaaatgtt tgatggatga gtaaagaaat cccaggatcc ctttgaggct acccatagac 110400
actgcagcat catttctaga atcaaggtcc cagggtcccc agtgtccatc actaggacac 110460
ttagttatgg ggattcctga gaggaaaaca gaggccttcc ccactgtggc ttcctgcgtc 110520
actcacatta ctgtcattcg gtgggtcagc agtaccccac agactcaggc agaggctcct 110580
gtttctatgt tcagcttcat tcctgttaaa ctaaaccagc ccatgcttct gcagagtgtt 110640
cctcaagacc agtttctcct gaagagcttt ccctggactg ccaccgttaa cagtctctct 110700
cttcatcaac tgagtgagga cacagacatg gcacagtgtc ctgcttacag ctgttgttct 110760
gctgctaagt ggctgtgtaa gcttagacac aacactcctg agcctttcct agtttgtcaa 110820
agaaactggg tgatgagcta gagcatcctg atgtgactag ggggcttccc tcaaaggctc 110880
tctgagcctt gattattgac ttgggttaga agttcaccca aaggaactga attttcaata 110940
gcagcaagca cattgttact gaacaaatga aaaataatta aatagctgca tgcaacgaga 111000
aagtgtcatt tgaaacttat agtgttcagg ttgcttaacc ccaggatagc tcctaactct 111060
ggctttagaa tgtggtggta gaagatactt cagctctggt tttctttgac cagtttggca 111120
atgggtaggc agatgggcta aggctgttct attttatcta cctgtcctat tcttcctttg 111180
gaaatttgtg tttgttttta gggtgttttg ggtttttgtt tttttttttt aagattgggt 111240
ctcactctgc cacccaggct agagtacagt atcacaacaa tagctcacag tagcctgaaa 111300
ctcttgagct caagtgatcc tcccacttca gcctcctgag tagctgggat tataggagtg 111360
agccattgca cccagccctt tggcatttta aaaattatat aaccttaaca ttttgtataa 111420
ttacaaaagg taaggacctt ttgtcattac catctttgag ccctccagag caaagtacat 111480
tttaaggaga gaatagcttg cgcatgtgtg tatctatgat agtgtcattc cttggtgttt 111540
atgagaaaga gtgagagagt gtgtttctgg atgtgtaatt aaataaataa catgtgttct 111600
tttatctaac agctgaagca atggaaggca tttgaagagg aaaaccaaac aatcagacgc 111660
atggccaaat atttcagcac tcccaacaaa agcttccata cccagtatgg tgaggaggag 111720
aactgccacc cgaggggaga gaaaagctcc atggagaggc tcctcacaga agtaagctct 111780
gcccctgcct ggaagattcc ctgtaaagga tccaatcatg catcggtggc ccccaaggct 111840
cttattgctg atgttctctt ttcctctcat tctcccactt ctcttaacag caagcaaaac 111900
ctcaccattt ccaccgtgac acgcatctac ttcattcatt cagtggacag atgtataatg 111960
agtcactcct atgtgccagg cattgtgcca gtgaacaatg aacaaaagca tggttcctac 112020
cctcacagag ctcacagtct agtggaagaa atagagattc attcatcaag caaacatgta 112080
attatacatt gtcataagaa ttatgaaaga aaaatcagag tggtaagaca gaataatgtg 112140
tggtaagggc aagaaaacat aacttagacc agtcagaaaa gactcattga gctgagggct 112200
gaaggttaag tacaaattag ccaggcaaag agtacaggga aaagtattcc aagctgcggg 112260
aacagcattg taaaggccct gaaatgtggt ggacactagc ttccctgtga tacattttct 112320
ctcttttttt tttttttttt tttttttgag atgaggcctc actctgtttc ccaggctgga 112380
gtgcactggt accatcttgg ctcactgaaa cctccacctc ctaggttcaa gcaattctcc 112440
tgcctcagcc tcccaagtag ctgggactac aggcacccac caccatgctc agctaacttt 112500
tgtattttta gtagagacgg ggtttcacca tgttacccag gttagtctca aactcctgac 112560
ctcaagtgat ctacctgccc tggcctccca gggtgctggg atcacaggtg tgagccgccg 112620
cgcctggcct cattttctct ttttacatag agtagtgtct tcatgtccaa gatctcctgg 112680
ggtccttact gtctttccca ggtactggct acagatctca atcagcccat catcccagaa 112740
agtccaggca tgtctacaga tggagaaggg gactaaacaa gggcttctga atgtgattgt 112800
agcaccaagg gagaatgagg cagctccccc gggcttcttt cttctgtatt tgagccagag 112860
ttggcccctc tcccagactt gggcagtgtg atgcaggcat gaagaaagca cgtggaaagg 112920
tttgaaggct tcgttgactc aggaagaagg cacagggccc aggggagtta gtcagtattt 112980
tgacactaac tgaattacat tccatatttt ttcagtttag aacctatctc aggaggtgtt 113040
atttggaaaa ctgggctttt tttttaggac tgctgcctag gtattaatag tccctgatga 113100
gaggatagtg tggtggggac ctagaaaaca caacagatga agggactcag cacacccagg 113160
cacccaccgt tcatgcccct ctatggttct ggaccatttt tgtccatcag agtaacacct 113220
ctccatttct ttactattaa gtatttcaaa gccagatttc tttccacctg gcaagggagt 113280
aatattgcct ttgatactct gtgaagtctt caaataagca tttttttttc ctggctacac 113340
agaaggccag aaacttggct agaacagcca ggatagtttt cattcacagt cagctgatgc 113400
tggaacagcc aagtggactg actctttagc cttatggtaa tttgcaacgt gctgtttgta 113460
cttctgccat gctaccctgt ttcccacgca gggactcaat ctgctatatc caaaaagatg 113520
ctttgagtct gcagaggaag cccttcaatg ggcacaggtg cacaagtggt aagaagctgg 113580
cctccccagt gcacgctaca cctggaatct ctttcccaga acaggccaga gaacaagcgg 113640
ccagtcctag ggcccggtgg caggtgtcag gaggttccag catctgcatc cccagctcca 113700
gcattgcccg ttagagaaac atgagtatct ctcctggctc aacatatgta cagaccttga 113760
ctctggccca tggtgtgcag tgccttcctg tgcaggcccc actcccccac tcaggccttc 113820
ctcttacttt cccgtgatct gggcagcccc atcttctcac acttttccct cttgcctcta 113880
tagccagggg tccccccaga agctgtttcg gacagcatct atcacatcta tcactgactt 113940
ccctgtctaa gagaaggcca gcagacagaa ccttccacaa ggctgaagtg ctttcctcat 114000
acactctgca gccaagtaaa caaacctatt acttttgtta cctgaaccat agaaacaaga 114060
ggctaattcc atgtctcctt atggcctgcc ccctgtgaaa catgcaggtg gatgttttgc 114120
ttccctcaat atgccaaaaa taataattaa taagctcatt gaagtgcagc tgccgtggta 114180
ggtcagattt cagtctcata atggcagtgc ctcacaccac acctctaatt agtatgcagc 114240
catggtaaaa acagagtccc acttcttttt ctggaagaag gaaattttct gtttaggttg 114300
atgtttctaa atctgtcacc agccagcttc ttcccaactc catgtttata gtatctttct 114360
atactcaaag gagtttatag ataaggcaca aaaagacagc actcagattt cacccacggg 114420
agtagttgcc atctgccgat gggtccttcc taactctgtg aggctataga ggcctccaga 114480
agcccacatg agaatgtgca cgatgggctt caggaggaga ggctggtgga ggagggagtt 114540
gaggtccccc catgagatcc tcagagagat gcctggcaca gcccaggatc acaaacacct 114600
gagtgtttcc ctattgctca tccattctgc ccctgacaag tccttgagtc atctgcactc 114660
acccagcaac acccagacct caccactctg cgggcagagg gaagggaggg aggacaggca 114720
cacatgtgct cagctgaaag tctcttctac cttactcacc agtccctcac tggccctgga 114780
ctctcttctg atggtaaaag aagtatactc aaccagggtg aaactagcaa taccaactat 114840
cagaaaaatc accttcccaa ttctacaagg ggagcagtgc atctgcttgg agagttgcta 114900
gtcagaatat tggactattt tgcttaagct actgctccct taaaggatca tttctaggca 114960
actctcccat gtaaacctga gatgaaacca caggttcact ctataactag tagtcctagt 115020
tagctgttat ggacggtata actaggcaat ttgtattggt tatcctaaca cagggaacat 115080
ccttttgttt ctagggcata ataaatggag gtccaaatgc tcatgcccag ctcctaaaga 115140
tgatagtaac aaagaggtag cattttggtg ttcagacaag cactttctag aacatttgct 115200
tacattattg ccttcccaga accctcgacc ccatgtcatc tgccccaagt ccagacgttc 115260
cctgtgaata tctcctccct gctctgcctt tgaggatcag aagtttccag agatggacac 115320
acagtctgaa ctagagaatc agctgctgca ccacagaaag atgtctgggc tgcagtcgtt 115380
ccctgcaacc cactgccaac actcctactc ctacttcatg ccccacaatc tcgcagttag 115440
gacaggcaca cctctgcagc tctcacctgc cagccctctc cggcacaact tgtttaccag 115500
ctaacatcca gcgagtaggc aggtcagtag cagaactgcc ccaggctcct tcgtctcctg 115560
ggctccattc tagggctgct gaatcaagct agcaggggct taagcccaac agtcctttca 115620
tttctttgtg cttcttcaat agttctgatg cttgcactcc tttaggtgag tggttcccaa 115680
catttttggc accagggacc acttccgtgg aagacagttt ttccacagat agtggtgggg 115740
ggatggtttc gggatgaaac tgttccacct cagatcatca gacattagct tctcataagg 115800
agtgtgcagc ctagacccct cacatgtgca gttcacaata gggtttgcgc ttctgtgaga 115860
atctaatgtc tcagctgatc tgatggaagc tcaggtggta atgcttcctc acccaccgct 115920
cacctcctgc tgtgcggcct ggttcctaac agtccatgga ctagtactgg tccgtggccc 115980
aggagttggg gacccctgct ttaggtgaaa tcaacagctg atattgccac atggtagctt 116040
tggccactca ctcccagagg tccagcctag ggaggtgata acaccaacct gagattctct 116100
ttggcccctc tcagctccaa tcttatttga ttgtcacaga aatctccacc cttctccttg 116160
ttcttcccat tttctaggct gtttagtaag aggcaaaata cttgttctcc tacttcttca 116220
tcccctggag atatgcttca catttatcta aatttttgca aaagtgtgat aaactccaag 116280
tgggaccatt ccaaacatta ttcagctcat acctgcggag tggcctgacc ctctcagttc 116340
tgggaaaggt gagagggcgc tgcagtggcc agcaggcact cagactgggc ctccttgctc 116400
ttcataagca atgccgcaca gtgtggggat gtaaggagaa gaccaagata atgacaataa 116460
atcatggttg gcctttattg agcaccgttt atgtcagtta ttgtgctagc actttacatg 116520
catcaactca tttcactgga gggaggcacc tccttagaac ctgaggtcac cagccaatac 116580
actggaagaa ctgagatttc agccaaggtt ctttgaaagc cacaccttct ccaccatggt 116640
gggcactatg gaaccctcgg cggcatcttt tgttgatggt tttgctttta ttttacagaa 116700
aaatgctgtg attgaaagcc tgcaggaaca agtaaacaac gccaaagaga agattgtgag 116760
gctgatgtca gctgagtgca cctatgacct cccagagggg gctgccccac ctgcctcttc 116820
cccgaacaag gacgtccagg cggtagcctc ggtccacacc ctggcagctg ctcaggggcc 116880
ttcgggtcac ctctctgact ttcagaatga tcctggcatg gctgcccggg attcccagtg 116940
cacttcaggg ccctcctcat atgcacaaag ccttgagggg cctgggaagg actccagctt 117000
ctccccaggg aaggaggaga agatatctga ctcaaaagac ttttctgatc atttagactc 117060
aggttgtagc cagaagccat ggactgagca aagcctgggt ccagaaagag gagaccaagt 117120
ccccatgaac cccagccaga gtctcctacc aganagaggc ggctcagatc cccagagaca 117180
gaggcatctg gagaactcag aggagccccc agagcggcgg tcacgggtta gttcagtaat 117240
cagggagaaa cttcaggagg tcttacaaga tctgggcctg ggccctgagg cttccctctc 117300
caccgccccc tcttgtcatc agcaaacctg gaagaacagt gctgccttca gcccccaaaa 117360
gatgcccctc tccaaggagc tcggctttag cccttacatg gtgaggagaa ggcgggcagc 117420
tcagcgggcc cgctcacact ttcctggctc tgcaccctca tctgtggggc atcgggcaaa 117480
caggactgtt cctggggcac acagcaggct acatgtgcag aatggggaca gccccagcct 117540
ggccccacaa actactgatt ccagagtacg aagaccttct tccaggaagc cttcactacc 117600
ttcagatcct caagacagac caggtaccct ggagggcagc aaacaaagcc agacagagcc 117660
cgagggggct agagggagca aagcagcctt tcttcgccag ccttctggtt ctggccgggc 117720
cccaagtcct gctgccccat gcctctccaa agcctcacct gacttgcctg aacagtggca 117780
gctgtggccc ccagtgccct caggctgtgc ctccctgtct tctcaacaca gctattttga 117840
tactgagtcc agcagctcag atgagttctt ctgccgctgc caccggccct actgtgaaat 117900
ctgcttccag agctcttctg actctagtga cagtggcaca tcagacactg accctgagcc 117960
tactgggggg ctggcttcct gggaaaagct gtgggcccgc tccaagccta ttgtgaactt 118020
caaagatgac ttgaaaccca cgctggtgtg aaaagcaaca gagctggtct agacacagag 118080
gtcagtccaa gagaagctgt accaaggccc acaggagaag agccaatttc tggtctttgg 118140
ggaacagatt agtgccctgc atttgaccag cccataccat gtttcagcta ggctcactgt 118200
gttactttga gtacttcttg atctataaaa agagaggcat tgcctgtcct gttactacct 118260
cgcagcctta ctataaaaga ctccagttga gtgactatga aagacactga ctccttggat 118320
aaaaggtgct gaatgaacac ataggatttt ctgtccaggt cagcctacat tctgtaaaac 118380
tcttaatata ttcagatgga tggctgaatg gacagacaga tggagagatg catgggaaat 118440
ttctgtagaa cttgaggtgt ggactgtgac ccatcaaact ggccttttgg tggacagacc 118500
taccaggaag ataagtctcc tacatccttg ggcctcccac tcctggaagg cagtggtttt 118560
atttctgctg aatgttgtga acagcacctc cctagattcc agcttctggc cagacccagc 118620
tcagagccac ccctacacca ctatttcttg atggtgtctt tccaccatta tggcacttta 118680
ccctcctctc tgagacagat ctccatgcgc ccgcaggctt cccagatctc tcccctggga 118740
tcggatgtac ctgaggtcct gactgtcccc actgtcccct tgtcctgtgg ctcatcctcg 118800
attcacccac tgatgcagtt ttgtactgcg gggaggcaca caccagcaat ttctgttggg 118860
gtatgggaga acctgttggt caagagtgct tttggttcca ttggggttac atgactacca 118920
acagacacat aaacctggaa gccaaatgga gaaataaaaa ggaagacacg agggacacga 118980
aaacaggaaa gaaaacagga tttgaatatt tcacttgagt ccagcatagt acttggcaat 119040
atcatatttt tgtgattcct tttgataacc ctgtgaagta gacactttca tttttacaga 119100
caaggattat gaggcttaga gaaatgaggt agtttcccgc aacatcacac tgctggacag 119160
agatgtacac acagctcctg ggactcaagt aggtgggttt tcccagggac acatggcttc 119220
atgtgttctt ctgggaatgg caggtgacgc ttggcagacg agacaacaaa gcaaggctca 119280
tgtaagaaag ctgggatgtg ctcccctata gtccagaata atagacctgg gtcctcacct 119340
caggaaacgg gcctccactt cctcactgcc aaaggccaca ctggcacctc ccaagggagc 119400
tggggagctg gtgaaggatg agtgcgagga actcagccac caccagagcc acagggagag 119460
cacacctggg tccactgtgc ttattgctga gctggctgtc atgtccaggc tgtcccctgc 119520
cccgagtcct gtgtatacat ctgtgggtgt gcacatgttt gcatgaagga attcaggcct 119580
tattaaatat tctcagaggg gggcatttgg ctctaaatgt atcatcaatt tatcatggaa 119640
tcttgggggc tgctgacacc cctggactct ccaggcactg aaccatgagg ccctcctgga 119700
agcacagctt cttctatcat ctacttttaa acaggaattt cctaatttat tctgtgcatg 119760
ggtttgcagt ttcttgtgct gtgtgtgtgc tgtccaagtg gtaccataat aaaagagaaa 119820
tgactcccga gaggagtctt ttcagaaact gtaatctggg gctggccagg aggggcccgg 119880
agaaggctga cccacccaaa gaaggggaac cagagaagcc atcagagctg ctgccgggct 119940
accctgggtc ccagtgtacc ttctaccaaa gttccatttg aacagattct tctgtgttct 120000
ccctaagaag cctcttatcc cagaaacact ccctcaatgg acataggaaa ccctggagac 120060
cctggactct tcctgcccct gggggtcctg tggctgggct ccccctcctg cagctccctt 120120
cctcccagca tgccaccact agcagcccac cattcattca tgtggactct aaatctggca 120180
atccttctag ccttctcact ctgtctgctt ctagaacctt agtcccacca tccccgccct 120240
tctacatctc catccttctg tttagaattt tttttcccac tttgtgccct tgtgaattat 120300
tcatccttca aggctcaggt ggagcataca ttctttcttc aacctttccc agccatcccc 120360
aaagaaagct gattgattcc ctagttaaat aaggaaggat gggctggaag cagtggctca 120420
cgtctgtaat cccagcac 120438
<210> 9
<211> 120450
<212> DNA
<213> Homo sapien
<220>
<223> E533D GPR156 GAT genomic DNA
<220>
<221> variation
<222> (117166) .. (117166)
<223> n is a, g, t, or c
<400> 9
ggggaccgtg ggcgtcctgc acatagcagc gggcttggcg cttctcggcg gtccgacgct 60
gatgaggtga gcacagcgac cttaaggatc cacaaaactt caaacactta attattaagt 120
gaaagtggaa agggggaggg gctttctctc cctttccaga atctgggcag tttgtttgga 180
accggtaaag aaactctcat aggaacttga ggtgagcagg ggtcacgcat cagggatgcg 240
agtggcaatt tcagtggaag agacgggaga gtactgtaat ttggtgtgaa gatggggccg 300
tgggttttct gctgaataag cgaccggctg tgctgaaaat gagagatccc gaaacagttt 360
cccaccgcct gtagactttc cagagtctcc tcacgccgaa tctgctttgc agggcatgtt 420
cacccccagg gtgtagagtg gcgggcacga tgggctcccc catggagatt gcaaagtcct 480
gaaaagggac aattgtattg cactgcgtct gttgaactgc cttgcttctg ggcatgaggg 540
agtcacctgg aagctgcaac atccttgtac cctggcaagc agccctttcc aagttagctc 600
tgtcagaaac tagaggcctc taggtagaac tcaaggtatc catgtactcg tgaagaatac 660
aaaccttgag gtttttaaaa tcgaattttg ttaagatttc aggatagaaa tctgggaaga 720
gaagtcatgg catggcataa cttacccctt tgttagtttt ctaggtacat gcatgcttga 780
attagaggta aatgatgccc tagcctatca taaaatgtct ttcctggtgt agttctttaa 840
accagaatat ggaggataac attacatttt tgcatcctag ataaaaggga aagattttca 900
gatggggctt acacagcggg agaaattgtt gatatagttg tattaggcag caaggcctgc 960
aaagaaaaac ttctttttct ccaccagtgg ctgaattctg cacagaatgt ctcctcgcag 1020
tctgggtagc agcccggctt gcaaaaacag tgcttctttc attgctgcag gtggggcaaa 1080
tgcgcttgcg gataaatggc tggggaagcg tttgcttaca ggttaaggca atttgagtct 1140
ggagaataaa gtgctttagc aggctgtgct tgagttaggt gtcccttgtg aggaatagag 1200
gtggctttct ggtccccatt ttgccagcct aattcccctt cagggacact actgtctctg 1260
gaatgttccc tctgtttccc cttctcttcc acccccagct tttagcttct ccccattccc 1320
cagtaaagtc tagaattgag cctggtcaga gtcaaagttc tgatagccta gggatataga 1380
acttcaagcc tggtgaaggc agaaatgaga cctaggagag acccaagatg ggtgagatga 1440
aacaactttc agcctagaag gctctcaaaa gagtggaaaa ataatgattg agggaaacag 1500
attctctgga aaggagaata ggtgcttaag tgtttgtttt cagctgaggg ttttaatatt 1560
tccatttttg ttgtttaacc ataagggaat ttccattata gggtaggagg aggatgaggc 1620
cttctctgaa aactgcatcc ttctccttga atttgcattt tattccattc ttatgtaggt 1680
ttcagagatt aattggggga agggggagag aggaaagaag ccagaggctc tgacatgctg 1740
cagaaacagt gcaacgtgga ctgacttggg ctgcaaaggt ggatttgggg gttgaaagaa 1800
atgttctaca tttagttgaa aaaaaaaaat cagagccttt attttgcaaa ggtcttgaga 1860
atcagaacat tcatgtttag ttgctgatga attttgcctg ataaaggatg caaatcacta 1920
tctcaccttt ttttctccag tactttatta tgaaaaattt tagacataca gagatgtttt 1980
ctacctctca ttttataaac ttattatctt aaaacaaact tgttaataaa aatcagtgtt 2040
tagaatccag acatatgtga tctggtcctg gacagagctt gaatcagaag gtgtttcaaa 2100
tatagatgtg tgaaggatat taacatttta agaaaaaaat atggatctta ttcttctgac 2160
tttcccataa gaatcttgag cagacccctt aactgccttc tttttcccat tcttaaaatg 2220
tcagtcagtt ggatgatatt actctcctgc ttaacaccct ccaatggctt cccctcacac 2280
tgtgaataac attcaactct ccaccagggc ttgtgatttg gtctggtgcc ctcatattct 2340
atggccgtcc tcttgcttac catcgtcctt gctcttccct ctgcctgaac actcttcctt 2400
cagacactgc cactgcttct tttctcagct cattccagtt tcttttcata ctctccagaa 2460
tgatggccac ctgatctaaa acagcctgtg gtcactccct gtcttctgac cctgctttat 2520
ccttcttcat ggcacttagc actccctgac actatatagt atatgtgttt ccttgttaat 2580
tgggcatgtt ccccactcta atgtaaactc catcaagaca aggaattttt ttgtcttatt 2640
tatggctgtg ttcctatttg gtatattatg agcaattaat aaataactgt tggattaatt 2700
aggtaactaa attacacaaa taaggcattg actcccataa gggtggcaga acccttggta 2760
aaatactaga agtcctttga ggtaattcat aattcaagtt aatcaatatt tgataggtaa 2820
atgatgaccc tggagatcag tggcctcttt tatcctcaca gcacttctca gctgaatcct 2880
atgctaatag ctggccagtt ttgacaaacc cacatcccaa acaagacata aaatatttca 2940
gtcacagaac ttttcctcac gtctctttct agtcacctcc accccacaga agcagcaaac 3000
cttgttctga tttctaatat catagattag tgttgctggt tcctgaattt catataactg 3060
cagttacaca gtatgcactc ttgtgtttgg cttctttttg ccctacacaa tgtctgtgat 3120
attcatctgt gccattgtgt gtatcagtag ttcatttctt ttttttccaa ggtagtattt 3180
attgtatgaa tattgaccat gtgtttatct gttctcttgt tgatagatac ttggttgttg 3240
ccagtttgtg gcaattttga acaaagctgc tgtgaaccta taaagggtct gcctcatctt 3300
gagtcttctc tactttatat gaaaatcttc cttgtgccac caatgcagag agaagtatgg 3360
caaggttatg ggggctgtga ctgatgtagc agcttgcatg taccccagcc agtgctctct 3420
ctagacagct ctgctgggag ctgacctgct tcccacttta gagggaaagc acttggaaaa 3480
tgagtgtcta acaaattagc gagccctcca gtgcactctt aagtgcttta aatccttgaa 3540
agagacactg tggaatgcct gctgccatca ctgttgtatt tccctcctcc tctcagcttc 3600
cccatcccag cacaagttga ctctaatcag cttctgagca ttatgctact gaggggttta 3660
aacattcatg agcaagagtc ttgttcagag cctgataaaa tattcatgtg tttccatggg 3720
gcattggttt ccatctagac ttctcaaggc atttttctga gatgcatgtc gtaattgtga 3780
agaactcaga cagtgatgga tgatacggcc ctgtgttatt aaaccctacc acacagagca 3840
ccttgctttc tagggatgga gaagaatgag cacacagaaa aattgacatt aatcctgtct 3900
agatcaagag aaaggctaca tgtactgata aaaatggctt gagtaaagag gggcctgtta 3960
atatagtacc aacaaaggta tgaatccata gaggagagtg aaaagaactt gttaaaatga 4020
gaggaatgct gggatgcagt cattccaagt ggaagaatgg gggaatcagc attgtaaaat 4080
gcacagttcc tttgacactc atgtggacga ggttcatatg agacaactgt gctgagtgct 4140
gtaattatca caacctgcta tgagaggatg agagtagaag tggaggctag gcagggtttc 4200
caagtagagc cagagagcta ttccaagagg agtcaacatt tctcttcaag gaagaagtgg 4260
ctttgagtca ggttctgaag gaggtgtgcc tctttgactg gcagctgcgg tgtggaaggg 4320
actttccaga gagacagaat agcatgatag agtgagggcc aaagtgccgg tgtggtgtga 4380
gtaaggagag aaggtgggtg gatgggggtc agggcagggt tgcagcaaga cataaagcag 4440
gagagctaaa ggccagctta tgaaggccac aggaggatgg acttcagtct gtttgctgga 4500
gggccgtgta acttttggcc agagattggg ttacattttg aggagttctt gggaagtata 4560
tccaccctag gcaaggcctt gaggtatgtt tatgtccaag gcatttccag aatattctgc 4620
tgtgtccaga acactatgaa gactctacgt ggtctactct aagagaggta aaccagagga 4680
ggtcagatat actcagtata ctcctgggac tgaccagaaa caggcctcac caggcacctc 4740
tctgccccca gcacacaaac actcagaata ttctgagtca gattgaatcc acagcattcc 4800
ctagacttct tcatgaccac tttgcctcag ctgggggagt tgcaatgatc taagtatccc 4860
cttatcacct gaatctgggc caggatacct cagacatggg ttgccaggca actgagggct 4920
aagtgatgca gctggccaat catccccaca aagcccaggt ctgctttgac caggccatcg 4980
ggctgtgacc agagaggcaa cttggggggt tgaggtcatg cagactgatg acttgtggac 5040
acaactgcca ggccccttcc atatgtcttc ttcctttggg ttgcagattt ctattcaaaa 5100
atgcctcagg atgttgattt tttaacccat aataaaaata gtgaagtagg gaggagtgtt 5160
aaacatgtca gtcatctata ccttatgttg tcattgggaa gaaataactg tggaaacaat 5220
tgtcccggga aagtcagtct tcagtcttgc agtgaggagc tttgcatatg tggagattag 5280
ctagaaagct ctggagttct gatggtgaga agggatttct tgggtcaagg ataggaaagg 5340
gcaagggagg accttcatga ttctccccag ggctttgctg gttggaattg ctcttctgct 5400
gccatgggta gcatggggtt tcagtgactg aaaacaccca ggaaagtatg ctctgggtct 5460
tcatgttgcc atctgcctac actggaatgt cagaccatca gtcagcactg ccagctctcc 5520
atcttgattt tctaagagtt attgagaaaa ccttgaaagg gaaggcagaa gtgggtgtct 5580
taactaggga aatgccaagg tcctaaaggt gtggtctagg ttgaaggtgt ggtaagggcc 5640
tgaagtcatt ggtctggcag tacttcagac caataaagtc tttcttggct cttatctaaa 5700
atattcctga ttttctgtgt gaggtggaat ctctcaagtg ctgcattaat cagtcttttg 5760
gctgaacagg taaatagggt gcatgcttaa ttgagtgcct tttctttttt taaagtttca 5820
gcttttattt tacattaaga ggatacatgt gtaggattgt tcatgggtaa attggaccca 5880
ggcataagca cagtacccaa taggtagttt ttcaacccat gccccctccc tcccttcccc 5940
ctgtagtagt ctgcagtatc tatctttcct gcgtttatgt ccatgtgtgc tcagtgttta 6000
gctcccactt ataagtgaga acatgtggta ttttgttttc tgttcctgca ttaattcact 6060
taggataggc ctccaactgc atccacgttg ctgcaaagga catgatttca ttatttttta 6120
tcctatggtg tttatgtagc acattttctt catccagtac actgttgatg agtgcctagg 6180
ttgattccac atctttgcta ttgtgaatag tgctgtgatg cacatatgca agcatgtgta 6240
tttatggtgg aatgatttat atttctttga atatataccc agtaatggga ttgctgggtc 6300
aaaggtagct ctgtatttaa gttttttgag aaatctccaa actgctttcc acagtggttg 6360
tactaattta cattcccacc aacaatgtat aaatgttccc ttttcttcac agccttgcca 6420
gcatctgttg ttttttgact ttttaataat agctattctt actggtgtga gatggtatct 6480
tattgtggtt ttatttgcat ttctctgatg attagtgatg ctgagcatgt tttcatgtct 6540
attggccaca cttgtatgcc ttcttttaag aagtgtcttt tcatgtcttc tgcccacttt 6600
ttaatggagt tatttgattt ttgcctgttg atttaagttt cttatatatt ctggatatta 6660
gacctttgtc agatgcatag tttgtgaata ttttctccca tgctgtaggt tgtttactct 6720
tttgatggtt tctcttgctg tgcagaagat ctttagttta attaggtccc acttgtcaat 6780
ttttgttttt gttgcagttc tttctgggga cttggccata aattctttgc caaggccaat 6840
gttgataagg gtatttccta ggttttcttc tatgattttt atagtttgag gtcttatgtt 6900
aaatctttaa tccattttta gttagttttt gtatatggtg aaaggtaagg gtctagtttc 6960
attcttctgc atatggctac cagttatccc agcaccattt attgaatagg gagtcctttc 7020
tccattgctt gttttttgtc agccatgttg aagatcagat ggttgtaagc gtgcagcctt 7080
atttctgaat tttctattat gttccattag tctatgtgtc tctttttgta ccagtaccac 7140
cctgttttgg ctactctagc aaattctttg gaattaagga aaatagggac acaatttatg 7200
aagacctctg ggatgtagcc aaagcaatgt taagaggaaa gtttatagcc gtaaatgcct 7260
tcatcaagaa gctggaaaga tctcacatta acaatgtaac tttgcattta aaggaactat 7320
gaaaaaagga caaaccaacc ccaactctag cagaagaaaa gaaataacta aaattaaaga 7380
aaaacttaat gaaattgaga tgcaacaatc catatgaaag atcagtgaaa ccaagaatag 7440
gctatttgaa aaaataaata agattgatag actgctagct aggttaacaa agcgggagga 7500
gacagtgaga gagagagaga ggatccaaat aagtacaata gaaataacaa agatgacatt 7560
acaactgatc ctatagaaat acaaaagatc cttggagaaa actatgaaca gctctatgca 7620
cacaaattag aaaatctaga agaaatcaat caattcctgg aaacaatctc ttgagattga 7680
atcggagaga ttgaagtcct gaatagacca acatcaaact ctgaaattgc atcagtaaaa 7740
caaacaaaca aacaaaaaaa acccttccaa ccataaaaag ccctggacca gatagattca 7800
cagccacatt ctatgagaca tgcaaagaag aactagtacc aatcctacta aaacttacag 7860
aaaatagagg agcagggact cctccccaat tcatcccatg aagccagcat cagcctaata 7920
cccaaatctg gcagagatat gatgaagaga tatgattttt gtgtctatgt tcagaccaat 7980
atccctgatg aacatagaca caaaaatcct caacaaaata ctagcaaacc aaatttagca 8040
gaacatcaaa aagttaattc accatgatca agcaggcatt attcctggga tgcatggttg 8100
gttcaacata cacaaatcat agtgagtcac catgtaaaca gaattaaaag caaaaaccgt 8160
tatgatcatc tgtgtcatct caatagacac agaaaaagct tttgataaaa tctaacatct 8220
cttcatgata aaaactctca acaaactagg catcgaagga acatacctca aaataataag 8280
ggccatccct gataaaccta cagctaacat catactgaat gggcaaaagc tggaaccatt 8340
ccccttgaga actggaacaa ggcaagaatg cccactctca ccactgctat tcaaggtagt 8400
gctagaagtc ccagccagca cagtctggca atagaaagaa ataaaaggca tccaaataag 8460
aaaagaagaa gatgaactat ctccctttgc tgacgatata attctatact tagaacaccc 8520
caaagactgt tccaaaaggt tactagaatt gaaaaatgat tttagcaagg tttcaggata 8580
caaaatcaat gtacgaaaat cagtagcatt tctaaacacc aataacgtcc aggctgagag 8640
tcaaatcaag aacatgatcc catttacgac agctgcaaag aaaaggaaat acctaggaat 8700
atagcaaacc aaaaaggtga aagagctctg caaggagaac tacaatacac tgctgaaaaa 8760
aagttagaaa caacacaaat aaatgaaaaa atatcccatg ctcatggatt agaaggatca 8820
atatcattaa aatggtcata ctgcccaaag caatgtatac attcaatgct attcctatca 8880
aactactaac atcagtcttt acagaattag aaaaaactat tctaaaactc atatggaacc 8940
caaaaagagc ctgaatagcc aaagcaagcc tgagcaaaaa aaaaaaaaca aagccggagc 9000
atcacactac ctgagtgcct tttctgaaca gatatttcaa tgattctgtg attattcatg 9060
agccagtgat ggctgcctgc ttttggatgc tgctaggata aatgcagaag atcagagtga 9120
agagggagag ggaagcataa cagcagcaga gaggaaaagg gaagagagta gtgacgtgct 9180
gaaatcgcag agattgtggg tacccagtta tctacaagtg agaaacaggg ataaaagaag 9240
atcaaataac tacccatggg aattttacat gcaaatattg ctgacttcca aggcagctgt 9300
gaggagaaag gaagggagga gacacaaagg cagctgtcac agtcaatccg aggaatatta 9360
ataaaaactt gacacatgaa aacacatggc cgtatcacaa cagcctgggt cccagcaagg 9420
atgtctattc aaacccctct ttcacatttc cttatattca ttcacagtat taggtatttt 9480
gcaagacatt catttgcact tgcaaagata cacaaatgca gagtacttaa aagggtaaac 9540
tatcctaaaa tattagtggt gagattataa atgattattt gtattttttc aacttatcta 9600
tgttttccat gattgtttta agaagtgtga atttctttga taatcagaaa aacattaagg 9660
agaaaggggg ttaagtaggg aggtagagaa agaggcatgg ggtggggaga gaggattgta 9720
gaaaagaaaa atatgttgga agatgaatga acaattttaa aactttatgt ttcacagact 9780
gctagcttgt gcatattttt ctttattatt gaatatatat gtttatcacc ctcagaagat 9840
ctggaagtac caattggcat gaaactgaat tgcaaatact gagctaagta tcacacctcc 9900
aagaccattg ccttggccag tgccattctg tgtgtgacat gtggcttcca gtgatgctca 9960
aagtattttc cgccaaaggc taatagagaa cacttcaaac ctgggcagca gcatctctcc 10020
cacagggttt aatatttata cttgtagcca cgtggctggc tttgtgcttc tcatctctga 10080
agtatggaac aggagccaac aaaggctgtc aatagttgga gtagtgggat tttccaagac 10140
aaaagcgtga gttattctcg tccacgtgtt tgctggctgc tcactggctc aggcagcccc 10200
ttggcaagct ctgtggctga ggctttaaat aaatagatgt agtttttgtt tcacaaccac 10260
tgaccttttc tggaggcact gttgattctg ggctttaatt ggcttctgtt gagtgacaca 10320
aggtgaaccc tctcttcaag agcagaagct cctatctgct gttaaccacc agcatcaatt 10380
caaagcaaat gccagaggac cacatacctc actgaactct ggggactggg gttacttgta 10440
gttatgtctc aataaatact ttttatattt taacttttgc atttttaagt tgtaaaagct 10500
atacacactc atggtaacaa gtctagtaag acagcagtat ataaagaaaa tatggccagg 10560
cgcagtggct caccccatag ttccaatact ttgggaggcc gagatgggtg gatcacttga 10620
ggtcaggagt tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatta 10680
ggctgggtgc ggtggctcac tcctgtaatc ccatcacttt gggaggctga ggcgggtgga 10740
tcacaaggtc aggagttcaa gaccagcctg gccaagatgg tgaaaccctg cctctactaa 10800
aaatacaaaa attagctgag cgcagtggca ggcacctgta atcccagcta cttgggaggc 10860
tgaggccgga gaatcacttg aacccggggg gcagaggttc cagtgagccg agatcctgcc 10920
actgcactcc agcctgggcg acagcatgag actccgtctc aaaaaaaaaa aaaaaaaaaa 10980
attggccagg taaggtggct catgcctgta atcctggcac tttgggaggc cgaggtgggt 11040
ggatcacctg aggtcaggag ttcgagacca gcctgaccaa caaggtgaaa tcccatctct 11100
accaaaaata caaaaattag ctggacgtgg tggcaggcgc ctgtagtccc agctactcgg 11160
gaggctgaga caggagaatt gcttgaacca gggaggcaga ggttgcagtg agccgagatc 11220
gcaccactgc actacaacct gagcgatgga gcgagactct gtctcaaaaa aaaaaattag 11280
tcaagtgtgg tggcgtgtgc ctgtaatccc agttacttga gagggtgagg cgggagaata 11340
gctcgaaata gcttgaaccc aggaggcaga ggttgcagtg agccaagatt gtgccactgc 11400
actccagctt gggctaccga gggagactcc atctcaaaga aaaaaaaaaa gaaagaaaat 11460
ataagtaatc tccaccttct ctcactccca tctttctgac aaaaccacta tttaaagcgc 11520
ccaggctggg cgtgcgggct gacatctgta atctgagcac tttaggaggc agaggcagga 11580
ggatagcttg ggtccaggag ttcaaaacag cctggacaac atagtgaaac tccgtctcta 11640
tgaaaaaaaa aaaaaaatag ccaagtgggt ggtatgtcat cctagctact tgagaggatg 11700
aagtgggagg atcgcttgaa cccaggaggt tgaggctgca gtgagctgtg atcatgacat 11760
tgcactccag cttgagtaac agagtgagac cctgtctcaa aaaaaaagtt tcatgtgtat 11820
tcacatgtca cgatcacagc tcactgcagc ctcaacatct ccagctcaag ggatccttcc 11880
acctcagcct gccaaataac tgggaccaca ggcacatgcc accacacccg tctaattttt 11940
aaacattttt gtagaaacga ggtctcactg tgttgcccag gctgatcttg aattcctcgg 12000
ctcaagtgat cctcccacct cagcctccca aagtgctggg attataggca tgagccactg 12060
cactcagccc cttcactcct tttctatgtt caaacaaaca tatgagtgtg tagacttatt 12120
ttctattgta tgtgaaaatg gaatcatata tgttattatt tctttcattt tatttagtac 12180
atattatgta cattattcta gattaacaca tataattgat ccaatttatt atttttaata 12240
gctacctaat attccattat aggaggttcc ataatttctt cccattcatt acttccccat 12300
tgatagatat tcatgttttt cttccaactt tttttgcaca acaacttatg ctacaataaa 12360
cattctacat ttattcctat actttgggtt ttatttccat aggagagatt cccaaaattg 12420
tcatttttgg gtcaaaggga atacacaatt ttaattctca ctgtaggtct cctttacagc 12480
agttgtttct ctcctccttt tgtctttctc tcccctctcc caccacattt tgccagcagg 12540
gcctgtgtgt ttaagaagga aagcctgcag tgagaactcc tctgtgccaa gtgtggatta 12600
tatcagctta gtggggaact ggagtctgca gtgtctcagt tacattgtgt ctctcttgct 12660
tttggttggc cagactgttc acaattcccc ttgctgattt attccatgct gtggaattat 12720
acatggtctt catccgtggc aggatcatct gaggggtggc tttttgggaa gggtgtcttt 12780
tcagaaagaa taggctcagt tactgtactt tctcacaaag ctatatctgt tatgtttttt 12840
tgttatgccc tttctttaat agttggattg aaaaaggttc ttcaattccc atcccggtct 12900
tctgtcttca ttttgaggac ttgggattta gggagtttta tgagtatata atcaatcaac 12960
tgtaactgat tatttgacat gaggataatt agttaagaag gtaggggtct tggagcttaa 13020
ggatcagtgc caagcaacag acgtgaacat ttttaaacaa atggttttaa caaacccggt 13080
attaggagca agcttcccag gagtactaag ctttcatttt ttaattttgc ccttgctggg 13140
atgtaaaact tcagtctagt ctaccagaat agagaggagc tggattctcc accacaccag 13200
ggctggagag gagaaaatgt cagagaagcg ttaagggaag ctggtaagta caaataagtg 13260
aaataaatat aaacagtgaa ctgacaaaat ggcaaaaagt gaatgaaatt tgaaaatcct 13320
cagctgaaga ttattgtgta accagtggtc ctgtgagcta gtggacactt tataaaaatc 13380
tgtgatctct aaaacatatt agatacccca gtgtgaatct gtgttcagaa tacaaccatt 13440
agctaagcaa gacagagaaa tgataagtcc tgttggcaga tattttgcta ttgacttcta 13500
taacatatgc tgcaattttt actcagcagc tttggaatgg atttctatgt cctaggttga 13560
aaactaaact aaaagaaaaa cagaatagaa gttactgcac ttaatttcta aggagaaaat 13620
tttaacttta gtttgtgcat gtatatgcct gcaaaataag cattaccctt tatgttaata 13680
caaacttcac atgaatgttt aattttcaaa tatgcactga ccagtaataa tgatggcaaa 13740
attagactct atagtaggtt tatgttttat aacttaggga ttctataatg tatcttagtt 13800
gatgtcgtag ttaatagtaa ggatagtaat atcttataca gtttgcactg tcgtctgagt 13860
aaagattatc tttaaacatt tgttcctgtc agaaaaattt taaggctaaa cctattataa 13920
gatattaagc atctgatttt ggctataatg gactatctgt gagtagattt ttactcctat 13980
acaggacatc tagaaaagct gagttttaaa aatctatttg aaggcataga agacctaata 14040
aggcagctag gacttgagag ctaagacctc agaaagaaga gaaactcatt gagtgttcca 14100
aattctaggc tactttttcc ctgtagacac ttaccatttt taagtagcac atgaggagaa 14160
cccaaacaat aagcagctgc taaaatcaga gaagccaggc agattattcc acagtctgat 14220
agggctgggg aggaaaaaaa aaaattgaat tcaaggaaac caaatgattc aggacatgag 14280
aaaccatgat catggacaga aaagaggccc agaaaaatca actcaatagt ctaagcaatt 14340
ttccttccaa gtcattcact gatttataag tagcgcagac caagaggttg caaaaatcca 14400
aacacaaaga aggtgctaaa aagctgagaa gctaatcaga gctacttgca atcttattac 14460
actaggaaga taaaaattat tatagaatgt aaagcccacc aatgtggtat ggcctgaaaa 14520
acaccctaag ctttcagttg ggactgctga cggattatgc ctgaccagtt aaaggaaacc 14580
agaaatagac ccggtcaaat aaaatattga agtccatttc ccgatcaact tagtcactga 14640
ttagattaaa gtaatctgtt cttattttaa caccctagca taagtcttct ccatattctt 14700
tggagaagaa aaaatgatcc agaacctgtg tatttttcat atgtggtttc tggtattcag 14760
caaagcaaaa caaaacaaaa acaggcatac caagatatag tttccagaat atggtacaga 14820
gagaacccag acttcctgag ttgagaagac agagctcccc atgtctgggg agaccagggc 14880
aactagagtt tgtaggacag agtattggag aggagagagc tgcagagaga accccagagt 14940
tcctcacagg gtacacctca agtataaagc tgagtactga gcagcacatg catgtaagga 15000
aactacctgg gataaagaaa gaactaccca aaaggattag aagaaatagt gctcattgtt 15060
cacacagggc tgggaattgt gcctattccc accagctaga cttgaaaagc tcataattca 15120
tggagggttg ggtagtatac tttgaaagac catgccttag tagtgggaag tagccctaga 15180
ttgagcactg cactgatcct gtctaacaaa tcttttaaaa agacccaaaa ggaacaaatt 15240
gttccagtta atttgactgc atcccagaac aaagctcaaa actatttaga ggtatttgga 15300
atagcagtat tagtaatatt gcagagggaa gaatattgcc agggataaag aaaatcattt 15360
cataatgata aaggagttga ttcatcagaa agacataaca gtactaaaca tttatgcatc 15420
taataacaga acttcaaaat acataaatga gaaattgata gtgttccaag gaggaataga 15480
caaatccata actgtagtcc aaagtttcat taaccttctc tcagtaattg atgaaataac 15540
agaaaataat taggtatata aaagaagata aaaatacaat caactagctt gacctcattg 15600
atctttataa gatactctac ccagctacag caaatacata ttcctctcaa gtgtacatgg 15660
aacatttatc cagttagacc atattctgaa ccataaaaca agtctcaata aatttaaaag 15720
gattttagtt atataaggtg tgttcttgat cacaatggaa ttaattaaga aatcagtaac 15780
aaaattctca aatatttggt aactaaataa catccttcag aataactcat tagtcaaagg 15840
agaaatcaaa aggaaaatta gggccgagtg gagtgactca catttgtatt cctaacactt 15900
tgggaagttg aggcaggagg attgcttgag gccaggagtt gaagatcagc ctgggcaaca 15960
gagtgagagc ctgtctttaa aaaaaataga aaaaaaaaat tagctgggca tggtggtgtg 16020
cactcataat cccagctact tagctggagg attgctttag cctaagagtt tgaggttgca 16080
gtgagctatg atcatgccac tgcattccag cctgggcagc agagtgagac cctgtctcta 16140
aaaaaattat ttttaataaa aaataaaggg aaatgagaaa atatttgggg ctgaaagtaa 16200
aagctcatat atcaaaagca gtacttaggt ggaattttat agtattataa gcttataagg 16260
tggggcacag tggctcacgc tggtaatgcc aacactgtag gaagtcgaga caggcggatt 16320
gcttgaaatc aggagttcgg gaccagcttt gacaacatgg caaaaccctg tttctataaa 16380
aaatacagaa aattagctgg gtatggtggc acgtgcctgt agtcccagct acttgatggg 16440
ggctgaagca ggaggatcac ttgagcccag gatttcgagg ctgcagtgag ccgagatcac 16500
accactgcac tccactccag cctgggtaac aaagtgagac cctgtccccc cacacccccg 16560
caaaaaaaag cttataagaa gaaaggtctc agattagtgt cctcagcttt catcttaaga 16620
aaccaaaaca gaaaaagagc aaatgaaatt caaaataagc agaagaaaga aaataagaaa 16680
tatcaaagca gaaatcaata aactagattt tgaaaagtag agaaaatcaa tgaaagcaaa 16740
tgctgtttca ttgagaatat taataaaatt gattaacctc ttgacagaaa acaggaggag 16800
gaaaaagaga ggagttacaa tttaccaata tcggaatgag agaggtgaca tcactacaaa 16860
ttctacagat actaatggat aataaggaaa cattatagct tttctccaat aattccatca 16920
acttattaat agatgaaatg aacaaattcc ttgaaagaca caagctacca aagttcactg 16980
aagaggtagt agagaatgta aaagcccaga tctattatag acagtctcga aagttagaaa 17040
tagaagagaa cttccctagc ctgataaagg gaatctatgc aaaacgtgca cctaacatca 17100
tatttagtgg taaagcaaat agtaatataa tcgatttttt ttcttttttg agacagagtc 17160
ttgctctttc acccaggctg gagtgcaggg gcgcgatctt ggcccactgc aacctccacc 17220
tcccgggtcc aggcgatctt cctgcctcag cctcctcagt agctgggatt acaggcacat 17280
gccaccacac cctgctaatt tttgtatttt tagtagagac agggtttcac catgttggtc 17340
aggctggtct tgaactcctg acctcgtgat ccacccacct tggcctccca aagtgctggg 17400
attacaggcg taagccactg cgcccagctt tttttttttt tttttttttt tttgagatgg 17460
agtcttgctc tgtcgcccaa gctagagtgc tgtggcgtga tcttggctca ctgcaacctc 17520
caactcctgg ttcaagtaat tctcctgcct cagcctcctg agtagctggg attacaggtg 17580
cccaccacca tgcccagcta atttttttat ttttagtaga gaatgggttt caccatgttg 17640
gaccaggctg gtctcgaact cctggcctca ggtgatccgc ccaccttggg atcaccaagt 17700
gttgggatta caggcgtgag ccactgtgcc tggcctgcct agacttttaa cttatttgtg 17760
taattacttc aagtatagat tactccaatt taaacacaaa gattgtgaaa ctagatgaag 17820
aataaacata ttcaaaatga ttattaaatg ttttaattgg tgacagagtt tttcatagcc 17880
ttttatcatc tcagtgcatc atgttttatt tgtaggtagc cacagagaaa cagctacatt 17940
tataagaaca ccatgaagaa taattaaaat gttctttttt tttttttgag acagagtctt 18000
gctttgtcac ccaggctaga gtgcagtggc aagatcttgg ctcactgcaa cctctacctc 18060
ctgggttcaa gtgattctcc tgcctcagcc tccctagtag ctgagattgc aggtgtggac 18120
cactacacct ggctaatttt ttgtattttt agtagagatg gggtttcacc atgttggcca 18180
ggcttgtctt gaactcctga cctcaggtcg atccacctgc cttggcctcc caaagtgttg 18240
ggattacagg tgtgagtgac cacacctggc ctaaaacatt cttttatccc tgacttcagc 18300
tgagtttagt ttgaaatgag gctctttatt tggggtgatt gggctttgca ggagggttgg 18360
tgggtggcct ataattcccc ccaatattgt atgtaagata ttacatgttt gtatacagtt 18420
tttcaggaga gagtccgtag ctttcatcag tctctcatga ccaaaaacta tttaagaatc 18480
atggcttgaa gaatgaaaga atcgagtgcc atgttaagtg tctaatttct caataatact 18540
tccctgaaac taatttctag agaataattc aaatgacttg atctaaatat gtgtgcatga 18600
gtcatcaaag cagcctggag taacatatta aaagttatcc caagggtctg tctggttcaa 18660
actctgatga aagccctata tttcttatcc tggactgggt ttctcatagt atgattccca 18720
gatcagcagc agcatcagca tcacctagga acttgttaga aatacaaatt ctcaggccgg 18780
ccccaggcca tacctactga gttacaaatt ggagatggga ccaggaatcg gtgttttcta 18840
aggagctttc caggtgattc tggtgtgcac taaagtttga taaccactgg gttaggctat 18900
aattagaaaa tcctgttctc cgccccgctc ccaagccagg tttagaacag tttgttaagc 18960
aagtatctgc agaaagacca gtctaatgtt gacagcttct attttccatc tttatggaaa 19020
aatcgtaaag cctcaaaagc ccaaatcacc ctcacacaag tgtcttgggt tgcacagcaa 19080
caccaaacaa cagtttagag taatccaatg tccagctgaa attggaatta tagagacaca 19140
gcatgtgagt tcactcacaa aaatttttac caggaggctt tttagggatg agccccgtaa 19200
ttccaagggc cttggctctc agcctccttt gaggcatata acacagtctc ttgaacagac 19260
tgaccctcag taatgaggtt tcattaccct cttccagaca tgtggcaccc tcacaaacat 19320
cctttaacag agtgctcagt atcaccatgc ttcgtttgca aagtaactta atgaattcgc 19380
tcagcctata ttcttagtac ccagtggtag ggatctcagc tgtagcagca taaaacttga 19440
actgtccaaa accagtctct gaaaccttca agtgtttatt ctgtctactc ctgctgttgc 19500
ttgaagcttg atttgttgtt acaccttact gttttgctga tgagaaatag cacagggtac 19560
ttctcagtgg ttctcattaa aggagggcag ccaagtggaa ttcattcttg gctcttaata 19620
gttttcaaat gagaatttta ttgcatacta atgagcacta attgacattt gtgactgttt 19680
tttatggaaa taatgcatgt acaatttgca taatagtacc taagtgcttt taggtaacag 19740
tacaactctg ggaagttggt gaaggttttt gtatgatgct ttttaaaaaa gttcccaaac 19800
cccagcccct agaatagtat agaatattaa caggtctctg ggatccaaat ataaggcagt 19860
agtagtgact cagttcctgt agttgtacca gcttgtacct gagagtcaga aaatgcatca 19920
gggcaggtct ctaaaagcag gaagcgctcc cacagtagcc agggaggatg ttccagccct 19980
ctctaccttc atgtgtcaac cctcctgctt ctcctaagtc atgagtatct agacagtgct 20040
gaggattgtt ccaaggactc ctacactgta aaatgttttc taaacatcac ttggttgata 20100
tcaacaaaca tggattgatc acctactatg tgccaggcac tgtgctagat gccagagtaa 20160
gcccatgttg gcttgctgcc tgctgcatcc ctatctctta gcacaatgag gcaacagtta 20220
tccatcaatg tttattgaat taatgaacat gctgtctgcc ctcagggatc tgaggattca 20280
ttattcttac aaaatctgac gttgaataca gtataaaatt tgttgctctt catgttagaa 20340
atattaatta ttcagaactt ggaattctgt taggaaattt agagaaacaa gataatcttg 20400
gttttatgtg ccccaagttt tctgtatatc aaatgaccct tttaaatttt gtgaaaatga 20460
aagaagccaa tgtttactga agatctagta cgtatcagtt acttttgcac acatcctata 20520
catcctatga tttaagcatc aacaaaacct atgaggtgta gatagtatta tctgtgttta 20580
attgagcaag cagctaagaa ctggagaagt gactaaccta aggcatcaca gatagaaaat 20640
tgtggaactg ggacttaaat tcagcctagg ctgtgtctgt tgcactgccg cttattacat 20700
taaatgatcc taggatatgt taagcaaagc caaactctga agtattgtac tagtgatacg 20760
gctccgatga ctggaggaac actggggttc ttggtctcat gccggtttgg ataaaatgac 20820
atggacacac gtggagtggt tttagggagg gaaaagttta ataggcagga aagcaggaag 20880
gaagaagaaa acagctcccc ggtacgggga gagaagtagg gggattcaaa caaagagaaa 20940
acctcatgtg cggcagaaaa gtggctgctt atatgaggat gcaggaggag gtggtgtctg 21000
atttgcatag ggctcagggg attggtttga ccagtcatgt cattcctgca gcctgtgaaa 21060
aaactgaccc tcccacccta gctttttaat atgcaaatgc agggcgccat tatgttttac 21120
acacatgggg acatgtgggg gtggccatgt tgccaggcac atgtaggggc aagggcaaga 21180
agatggcagg aatcaccatg tttggatgga cccagtttct aatggctggc atttgcatat 21240
caaagcttgc tggcccagct cagagccggg gctttcctgc tagacaagaa acgtttctgg 21300
agctgcttta aaagaaataa aaactcccca aggacccctt ttcctctcta tctgcctaaa 21360
ataatttatt aataactcct gtaacactag gatggaggga tgaattggtc caggggtctt 21420
ggtgtgtgcc ctgcattcag ttgacctact gtttacaata cacctactgt ttacaacact 21480
attttctaga tcttgtgggg aacccaaacc aagggccagt ctggctcacc tataattcca 21540
ccaagcagcc agaaaagtat aaacgctcta cagcaaaggg ataaatcaag gtttagtaga 21600
agaaaagctt tataagtaat gtggaactaa aaggttgaat atagttttca ataatgttga 21660
gcataaatgt tctccagatt gtggaaagat cactaactgt tggctgggaa gggtaggaga 21720
ggagagagtt tgaaacacag agaataggaa ggagtggtga tgtagtccaa taactcaccc 21780
agaacccatg gacgtgaaag ctttgtttgc tctcagatcc ataactagac taaaggagtg 21840
aatcagatct gctcccctgc accccaccct gctcaccttc cacacctgcc aagggccacc 21900
cagcaattcc attctgcttg tcaaatcccc taaggaggat atgtctggaa cagccaccac 21960
tcctccccct gctcttccct ctggtatgtc aggattccct gcacaaccgt gctccagggt 22020
ccttgggatg attattcaga aaccagagaa gtatgtagaa aacttaatcg gaggcactta 22080
aaggctttaa aagggaattt taaaaaccat ctttccctct tttataaggc agtctgagta 22140
tttaagaagc aaattaattg agtccacttt acagtgttgg ggcaaaagca tgcaagttcc 22200
aacatttaca cactaacaga aaattctttt cccttccact gtgctccttt tctttcttgg 22260
gcctgctcca caaacttcta accacagtcc taaattggta ccccatgacc ctgtgtgctt 22320
cgattgccta cactggtttc agacccacgc tgtggattca aatcaaacct gcctttctcc 22380
ctgttactat gtccacccag caccctcctt gcacacacag tctttctctt ctttcctcca 22440
tgtgcagacc tttaccacag ctgtcccaaa tgtgtgaaag gccaaccata actcttcctt 22500
taaaggtcct ttagagcagt atggaaagag tgctgaactt ggaagaccta gattctcttt 22560
ctatactcat tatgtgatcc tgagcccctc acttaacctt gcagggcact tacaaaataa 22620
agagatggag ttcatgatat cttaaggtca ttttccatgt ccaacattct ctgactcttc 22680
atctttccct gactcaacat tctgttccta tatagtcaac accttcccac cttaatctca 22740
tgctcatgcc ctcttagaaa gtctttacaa ctgttgaggg tgcagtggct catgcctgta 22800
atcccagtac tttgggaggc cagagtgggc agattgcttg agctcaggag tttgggacca 22860
gcctgcataa catggtgaaa ccccgtcttt attaaaaata caaaaaaaaa aaaaaaaaag 22920
ccagatgtgg tggtgcttgc ctgtggtccc agctactcag gaggctgaaa tgggaggatc 22980
acttgaaccc aggaggcaga ggttgcagtg agctgagatc atgtcattgc attccagcct 23040
gggtgacaga gagacaccct gtctcaattt aaaaagaaaa aaaagaaaga aagcggcggg 23100
ccgcggtggc ttacacctgc aatcccagca ctttgggagg ccgaggcagg tggatcatct 23160
gaggtcaggg gttcgagacc agcctggcca gcattaagaa actctgtctc tattaaaaat 23220
acaaaaatta gctgggcatg gtggtgggca cctataattc cagctactca ggaggctgag 23280
gaaggagaat cgcttgaacc cgggaggtgg aggttgcagt gagttgagat cgtactattg 23340
cactccagcc tgggcaagaa gagtgaaact ccatctcaaa aaaaaaaaaa aaaaagaaaa 23400
tatttgcatc tgtgaactgt cttctgtgtt gaggatgttt gtggcagaag gagatagacg 23460
taggctctgt ctacgtctgc ctggtgcctc cacaaggagc agtgtatgct cagagaatag 23520
aagtgaattt tactattagt ataggtgacc catattgaaa atgtttgtaa atctgctacc 23580
agaacaacac agtcattcaa agacaattaa aaatgcattt tatacttcct gctatttata 23640
attattcatg gatctgctgc ctacagtcag gtagtaaaag gagagccaga aggaatcata 23700
gtgaacatct catacaatgc tatctttgtt gttggtttga acataagcat ttttgcgtga 23760
atttgcgtgt aggtctcttt tatttctctt attgcataac ctgaggctga aatacttcaa 23820
gtaatgtatc tatttgctca tattgggtag aaacatccct attattccaa ttttcccttc 23880
tcctgcttaa aacatatagt gaaatgaaag atgcagagat aaggaaatca gggaaaagaa 23940
aaatagtcat aggatactaa aatgagccac agatacctga aactgcatag ttgctataaa 24000
tgagccataa atttgattct gagctttcca gtggccccaa aaagataaac ataatagtat 24060
ttattccatg acataaaaat gtatttgtat ttctctgtgt tcaagaggaa gagaaatttg 24120
tactatgggt cctcatgaag gagccactaa gtcagtgttg tagaccacac attcaacgat 24180
atcgtattaa tacccatgat gatgaattca ttcattcaat aagcatttat tgagtactta 24240
ctttgtgctg tatatgtttc agtgtattgc agtaattatt ctttttgatg ctcaaattgt 24300
cctattgtgg gtcagtagga gcccgttgat tcatgtcctt ttgacattat tctgtagttt 24360
ttgatacttt ttttcctagc atgatgagat gttccaggct tatgtcgtat atttcttgtt 24420
ccgtaactca aattgaccat tttgttaatg aaacttgatt tttttcagtg aaaagtggtt 24480
ttatagaaca caatctgggc acttgaagtg tttattgtta ctgggttgtc attacttaca 24540
agactcagtt aacaaattag gaaaaagatt gatttagaaa gaaaataaat cctgagttca 24600
tattgttatt tccaatttaa agattaaagg gttttcgtat aacttatttt atatgtgtat 24660
gtcttttctc ttactttgaa atcttggttt ccaataacat gaacataatt acttccttta 24720
tcctaatagg tacgtatatg tgtatatgtc tatgtatgta tgtatgtagg tatgtatgtg 24780
tgtatgtttc tatctgtaaa acaggaaaaa tacccaccta atggagctta agatttcttt 24840
atgagtattt tttgtcctta gggtatttaa tcaaattact gttacttaaa ataatgtttc 24900
tctatgtggt tatgccatca acttcatata caattatttt atttcaattt gtcttcgatt 24960
tttaaggatg gttttcttct tctgatttaa ttttgttttt aaattatgta aaatattttc 25020
ttggtttcag agtcaaatct atgaacattg agaggtctat tttgcctctc tgtcccctcc 25080
cccttattat tttactcccc ttatagataa tgcttttatt tttccattac tttttttttt 25140
tttttttgga gacaggagtc tcgttctgtc acccaggcag gagtacggta gtgtgatctc 25200
ggctcactgt aacctccacc tcccaggttc aagcaattat cctgcctcag cctcctaagt 25260
agctgggact acagacactg accaccatgc ctggctaatt tttgtatttt tagtagagac 25320
agggtttcac tgtgttgatc aggctggtct caaactcctg acctcaagtg atccgcctgc 25380
cttggcctcc caaagtgccg ggattacagg tgtgagccac cgtgcccagc ctctattact 25440
ttttgaaaat aagccaatga cctatatgta tcctatctcc tttcttacac aaaaggtagc 25500
aggccagagt tcaagattac agtgagctgt catcatgcca ctgcacttta gcctgggcaa 25560
cagagtgaga ccttatctct aaagaaaaac aaacaataaa aaattttaaa aataatttct 25620
atgaattaaa aataatttta aacacaactg catatgaaga caacaaagga aaactctcag 25680
gaaacactga aatatgaaaa tcaagtgaga ttagagcaaa taaggatgtg tatgggaagg 25740
ttctgtagaa gacagattga ggcccaaaca gagagagctc taaatacatc atgaaggtta 25800
ccagaaatgt gagaaattcc tgaagaagag ggaagaagca aatcctctcc aaatttagtt 25860
cacttagttg ataatcatta gttgattccc agtagagtca gtcttttatc atcagtgcca 25920
ccactgttgt tctctgcatt aacaaaggag atattaatct ggaaagctgc aatcattttc 25980
actgtagaat cagcctttta ttttttaggg ttttttaatt tttttttttt aggacacctt 26040
catttaagat cacttcatat ctcctctggc ttttgcaaat gctctttggc tgatctactg 26100
tttccaccac tgtcctcaac attttttagt atattattta atttatgtat gtattggtgt 26160
ccactgatta ttgtttgcct tcccccattg gaacacagat tctataaaag tagggatctt 26220
tattttgttt accactgtat tccaggtgcc tagaacagtt cctttcacat tgttggtgct 26280
caaaaagaaa aaagttaaat gaatgaatat cagcagcaag agcattttga ggagaaagca 26340
aaggtgtaac tgtgggggtc tccattaatg tatgtatatc atcctcttat acatttgtcc 26400
catcacccgc tagccctgga actctcatta tttttttttc tggtaatgca ggctccaact 26460
caactggcaa tgagaatatg aactgaggca actgtatttg aaaaatgaaa gaatataggt 26520
gatatgggtt taaagaattc agtatttgtg tatttttcca ataagtacat gcttatgagc 26580
atagccttac aaaataacaa aaataatttt ttacatttac tcacacactt accatttcca 26640
gcactcttca ttcctttgta tagatccaaa tttgtatctg gcatcatttt acttctgcct 26700
aaagaactaa ctctaacatt tttttatagt gcatgtctct cagattttct ttgtctgaaa 26760
attactttat tttaactcca tttctgaaat acattttcag tgggtattgt attctgggct 26820
gacttttttt ttttttccca gtgcttgaga gatgccattc cattctcttg tggctttcat 26880
tatttttgat gaaaaatcag ttgtaagtct tactcttgtt cctctgtaca taatctgact 26940
gctgcttcta aaattttatc tttattgctg gtttttagca atttctgtgc cttgttttgt 27000
ttttgttatt tagtgtttgt tctgcttggg attggttgag cttggatctg taggtttata 27060
cttttcatca aatacgaaaa attttggtca ttatttttca aatatttttt ctactcctcc 27120
ctcctcactt tttccccctc aaacagcagt tacatgtatg tcagacaact tgctattatt 27180
ctataagtca ttgagacaat gttcattctt ttttattttt aatttttgtg ggtaaatagg 27240
tgaatatatt taggggttca tgagatgttt tgatataggc atgcaatgta aaataagcac 27300
atcatggaga atggggtatc tattccctta agcatttatt ctttgaatta aaaacaatcc 27360
acttacactc ttatcacttc tcagcctttt gggataagat catgtgtaaa aacaatgtac 27420
ttacactttt cattttaaaa tgtacaatta agttattatt gactatagtc accctgttgt 27480
actatcaaat agtaagtctt actcattcta actaattttt tataaacttt aactataccc 27540
acttctcctc ccacctccca ctccctttcc aacctatggt aaccatcctt ctatactctg 27600
ttcatgagtt cacttgtttt gatttttaga tcccacaaat aaataagaag atgtgatgtt 27660
tgtctttctg tgcttggctt atttcactta acgtaatgat ctccagtgcc atccatgttg 27720
ttgctaatta ctggacctaa ttcttataca tggatgaata gtacatcatt gtgtagatgt 27780
accacatttt ctttattcat tcatctgttg atggagactt agattgcttc caaatcttag 27840
ctatagtaag caatgctgca acaaacagga gtgcagacat ctctttaata tactgctttt 27900
ctttcttttg ggtatatatc cagcgatggg attgccagat catacagtag ctcaattttt 27960
agttttttga ggaacctcca aactgttctc cataatggtt gcactaatgt acattcccac 28020
caacagtgta caagggtccc tttttctcca catcctcacc agcatttgtt attgcctgtc 28080
ttttggatat aagccatttt aactggggtg agaagatatt ttagttttca tctgcatttc 28140
tctgatgata aatgacattg agcatctttt catatacctg tttgccattt gtctgtcttt 28200
gttggaaaaa tttctgttag ctcttttgcc cattttttta atcggattat taaatttttt 28260
cctatagagt tgtttgagct ccttatatag tctggtgatt aatcctttgt cagatgggta 28320
gttggcaaat attttctgtc attctgtgag ttgtctcttg actttgttga ttgtatcctt 28380
tgatgtacag aggctttgta acttgatgtg atcctatttt tccatttttg ctttggtcgc 28440
ctgtgcttgt ggcatattgc tcaagaaatg tttgcccaga ccaatgtcta gagactttct 28500
gcaatgtttt cctgtagtat tttcatagtt tgaggtctta gatttaagtc tttaatccat 28560
tttcatttga tttttgtata tggtgagaga tgggtgtcca gtttcattct tatgcatgtg 28620
gatatccagt tttcccagta ccatttattg aagagaccct ctctttccca gtgtatgttc 28680
ttggcacctt tgccaaaaat gagttcactg tagtttctgg gttctctctt ctgttctatt 28740
ggtctgagtc tgtttttatg ccagtactat tctgttttag ttacaatcat tctgtagcat 28800
aatttgaagt caggtaatgt gattcctcca gttttgttct tttcactcag gataccttta 28860
actattctgg gtcttttgtg gttccacata aattttagga ttgtattttc tatttctgtg 28920
aagaatgtca ctggtatttt gatagggatt gcattgaatc tgtagattgc tttgggtagt 28980
atggacattt taacaacatt gattcttcta atccatgtat atgggatatt tttccatttt 29040
tggtgtcttc ttcaattttt ataatctgtg ttttatagtt ttcattatac agatctttca 29100
cttctttggt caggttaatt cctagatatt taattttatg tgtggctatt ataaatagga 29160
ttacattttt atttcttttt cacatagttc actgttggca tatagaaatg ctactgattt 29220
tttataaact tttatgttat gttcaggtgt ataggtacag gtttgttata taggtaaact 29280
catgtcatgg ggtttgtcgt acagattatt tcatcaccca ggtactaagc tagtacccat 29340
tagttatttt ttctgatcct ctccctcttc ccactcttca ccctcagtag gccccagtgt 29400
ctgttgttcc cctctgtgtg tccatgtgtt ctaatcattt agatcccact tgtaagtgag 29460
aacatgcagt atttggtttt ctgttcctgt gttacttttc taaggataat ggcctccatc 29520
tccatccatg ttcctgcaaa ggatataatc tcattctttt tatggctgca tagtattcca 29580
tgatgtatat gtaccacatt ttcttttttt ttcccttcaa cttttatttt aagttcaaga 29640
gtacatgtat gtacaagatg tgcaagtttg ttacataggt aaatgtgtgc catggtagtt 29700
tactgcacag atcatcacat cgcctaggta ttaaggccag catccattag ctattcttcc 29760
tgatgctctc cctccctcac cacaccccct ccgacaagcc ccagtgtatg ttgttgcccc 29820
ctcacatgtg tccatatgtt ctcatcattc agctcccact tataagtgag aacatgtagt 29880
gtttgggttt ctgttcctgc attagtttgc tgaggataat ggcttccagc tccattcatg 29940
tccctgcaag gaacatgatc tcattccttt ttatggctgc atagtattcc atggtgtata 30000
tgtaacacat tttctttatc tagtatatca ttgatgagca tttaggttga ttccatgtct 30060
ttgctattgt taatagtgct gcagtgaaca tatgtgtgca tgtatctttg taacagaatg 30120
atttatattc ctttggatat agacccagta atgggattgc tgggtcaaat ggtatttctg 30180
cttctaggtc tttgaggaat tgccacacta tcttccacaa tgattgaact aattcatact 30240
cacaccaata attccttttt ctccacaaca ttggcagctt ctgttgtttt ttttgacttt 30300
ttaataatag ccattctgac tggcatgaga tggtatctca ttgtggtttt gatttgcatt 30360
tctctaatga tcagtgatgt tgagcttttt ttttcatatg tttgttggcc agatgtatat 30420
cttcttttga gaagtgtctg ttcatgtcct ttgcccactt tttaatggtg ttgtttgttt 30480
ttcttgtaaa ttggcttaag ttccttgtag actctggtta ttaaaccttt gtcagataga 30540
tagattgcag aaatttttct cccattcttt aggttgtctg tttgctctaa taatagtttc 30600
ttttgctgtg cacaagctct taagtttaat tagattccat ttgtcatttt tgctttcatt 30660
gcaatcactt tcggcatttt tgtcatgaaa tcttttcctg tgcttatgtc ctgaatggtt 30720
ttgcctagac tttcttctag agtttttttt tatagttttg ggttttacat ttaagtcttt 30780
aatccatctc cagttaattt ttgtatgtgg tgtaaggaag gggtccagta ttaattttct 30840
gcatttggct agccagttcc cctagcgcca tttgttaaat agggaatcct ttccctattg 30900
cttgtttttg tcaagcttgt caacagtcag atggtggtag gtatgtggtc tgatttctga 30960
gctattttgt ttcattggtt tatgtgtctg cttctctaca actaccatgc tatttgggtt 31020
actgtagcct tgtactatag tttgaagttg ggtagtgtga tgcctcaagc tttgttcttt 31080
ttgcttaata ttgccttggc tattagggct cttttttggt tccatatgaa ttttaaaatg 31140
attttcttct aattctgtga agaatgtcaa tggtaattta atgggaatag cattgaatct 31200
ataaattact ttgggcaata tggccatttt catgatattg attcttccta tccatgagga 31260
tgaaatgttt ttccgtttgt ttgtgtcttc tctgatttct ttgagcagtg gtttgtagtt 31320
ctccttgaag aggtccttca cttcccttat tagctgtatt cctaggtatt ttattctttt 31380
tgtagcaatt acgaatggga gttcattcac aatttggctc tctgcttgcc tgttgttggt 31440
gtataggaat gctagcaatt tttgcacatt gatgtttata tccttagtct ttgctgaagt 31500
tgcttatcag cttaagaagc ttttgggctg agacaatggg gttttctaga tataggatcg 31560
tgtcatctgc aaacaaagat aatttgactt cttctcttcc tatttgaata ccatttattt 31620
ctttctcttg cctgattgcc ctggccagaa cttctaatac tatgttggat agaaatagtg 31680
agatagggca tccttgtctt gtgccagttt tcaagggaat gcttccaact tttgcccatt 31740
cagtatgata ctggctgtgg gactgtcata gatggctctt attattttga agtatgttcc 31800
ttcaatacct agtttattga gagcttttaa catgaaggga tgttgaattt tatcgaaggc 31860
cttttctggg cctattgaga taatcatgtg gtttttgtct tttattctgt ttatgtgatg 31920
aatcacattt attgatttgc atatgttgaa ccaaacttga atctcaggga tgaagccaac 31980
ttgatcgtag tggatacgct ttttgatgtg ctgctggatt tggtttgcca gtattttatt 32040
gaggattttt gcctcaatgt tcatcaagga tattggcctg aaattttctt tttttgttgt 32100
tgtatctctg ccaggtttgg tatgaggatg atactggcct caagaatgag ttagggagaa 32160
gtccttcctt ttcaattttt tggaaaagtt tcagtagaaa tggtaccagc ttttctttgt 32220
accgctggta gaattcagct gtgaatctgt ctgatcttgg gctttttttg gttgttaggc 32280
tatttgttac tgcctcaatt tcagaacgtg tcattggtgt attcagggat tcaatttctt 32340
tctgcttcag tcttgagaag gtgtatgtgt ccaggaattt atccatttct tctagattct 32400
ctagtttatg tgcatacagg tgtgtgtagt attctctgat ggttgtttgt atttctgtgg 32460
gatcagtgat gatatcccac ttaacatttc tgattgtgtc tgtttgattc ttctctcttt 32520
tgttctttat tagtctagtt agttgcctat ctttttatta attttaaata aaacagctcc 32580
tggattcatt gatttttttg aaaggttttt tgtgtctata ttttcatttc aactctgatc 32640
tgatcttggt tatgtcttgt cttcttctag ctttgaaatt tgtttgcttt tggttctgtc 32700
attcttttag ttgtgatatt aggttgttaa cttgagatct ttctagcttt ttgatgtggg 32760
catttagtgc tataaatttt cctcttaaca ctgcttcagc tgcaccccag agattctggt 32820
atgttgtctc tttgttctca ttagtttcaa ggaatttctt gatttctgcc ttaattttgt 32880
tatttaccca ggagtcattc aggagcaggt tgttcaattt ccatgtagtt gtgtggtttt 32940
gagtgaattt cttaatcttg agttctaatt tgattgtgct gtggtcagaa agactgttat 33000
gatttcaata cttttgcctt tgctgaaaaa gtgccatgtg gtgatgagaa gaatgtatat 33060
tctgttgttt ttgggtggag agttctgtag atatctatca ggtcctcttg atccagagct 33120
tagttcaggt cctgaatatc tttgttaatt ttctgtctca gtgatatgtc taatattttc 33180
agtggagtgt caaagtattt cactattatt gtgtgggagt ctaagtctct ttgtaggtct 33240
ctaagaactt gctttatgaa tctgggtgct cctgtattgg gtgcatatat atttaggata 33300
gttagctctg cttgttgaat tgaacgcttt accattatgg aatgcccttc tttgtctttt 33360
ttttatcttt gttggtgtaa agtgtgtttt gtcagaaact aggactgcaa cccttgcttt 33420
tttctgtttt ccatttgctt cataaatttt tctccattcc cttattttga gcctatgtgt 33480
gtctttgcac ttgaggtggg tgtcttgaag acagcatact gatggccctt ggctgtttat 33540
ccagcttgcc attctgtgac ttttaattgg gggcatttag cccatttata tttaaggtta 33600
gtattgttat gtatgaattt gatcctgtca tcatgatgct agctggttat tttgctgact 33660
tgtttttgtg gttgcttcat agtgtcactg gtctgtgtac tttagtatgt ttttgtagta 33720
gctggtaaca gtttttcctt tccatattta gtgcttcctt caggagtgct tgcagggcag 33780
cctggttgtg acaaattccc tcagcatttg cttgtctgaa aaggatctta tttctccttc 33840
acttatgaag cttagtttgg cccgatgtga aattctggat tggaaatatt tttctttaag 33900
aatgttgaat attggtttcc agtctcttct ggcttgtaga gtttctgctg aggagtccac 33960
tgttttctgt tgggcttccc tttgtaggtg acctggactt tctctctggc tacccttagc 34020
attttttttt tcattttcac cttggagaat ctgatgatta tgtatcttgg agttgatctt 34080
cttgtggagt atcttactgg ggttctcggc atttcctgaa tttgaacttt ggcccatctt 34140
gctagcttgg agaagttttc ctgtatgcta tcctgatgca tgttttccaa ctcagttcca 34200
ttctgcccct ctctttcagg taccccagtc aagtcatagg tttggtctct ttacataatc 34260
tcatatttct ctgaggtttt gttcattcct tctcttttta tttgtttctg tattcttgtc 34320
tgcctgtcta tatgcagaaa gatagtgttc aagctctgaa attctttcca ctgcttggtc 34380
catcctatgg atacttgtga ttgcattgtg aagttcttgt gtattacaag aactttattt 34440
ttttatcttt atccagtcta ccattgatgg gcatttaggt tgattctatg tctttgttat 34500
tgtgaataat gctgtaatga acatactaga atgattcatg tttatttggg taaatgtgtg 34560
ttgatttcgt atcctgcagt tttattgaat ttatcagttc taatcatttt tcttgtggag 34620
tctttaggtt tttccaaata taagatcata ttgtctgcaa acaatgatca tttgagttat 34680
tccttttcaa tttggatgct ttttatatct ttctcttatc taattgctct agctaggact 34740
tccagtagta tgttgaataa cagtgatggc agtgggcatc cttgttgtgt tccagatttt 34800
agaggaaagg ctttgtcctt cccctatgcc ccaggtaggt ccaggagtca aggactagag 34860
tccaaaacct tagaagtcta cctggtattc tattatactg tggctgagct ggccctcaga 34920
ccacaagaca cagtccttcc cactcttctc tcccctttcc aaaggcagag gaactgcctt 34980
tagtagagac agggtttcgc catgttggcc actgccaacc cagcccatga ggaggactgc 35040
cagactactg ctgatgttcc cttaaggccc aagttctctt aaatcagctt gtcctgaatg 35100
ttacctagcc tgagactcac ccttcaggac agtgggctcc cctctggccc agggaaggtc 35160
cagaaatgct gcccaagggt caagtcctgt aatcagggac tccaagagcc ctcttggtat 35220
tctaaccccc tgtatctgtg gtggtaccta aggtgcaaga caaagtccct tttacatttc 35280
cttctgcttt tatcaagcag aagttttgtc ctgcagccac cacagctggt aatgtactga 35340
gttctacctg aagccaggaa gtctcagagg ctcacccaag gccctcaaca tagtccctgg 35400
ttattgctgc tggttattca gaaccaaggg ctcttcactt agcaggtgat aaatgccggc 35460
agggctgggt cctttccttc aatgcagtgg gttccctctg gcccagggtg tgtctagtaa 35520
tgtcacctgg tttctagggc ctagaatgga ggcctcatga ctctgaccag tgccctatcc 35580
tgctgtggct gcgctggtat cctagacgca agacaatggt ctccccactt ctccctctcc 35640
tattctcaag tggaaggaag gggtctcttt tggagctgta agctgtgtag cctggggtaa 35700
ggggaggggt gatgccaata ctctcttggc tgccccagct ggtgtctcag taggttgcat 35760
gcactcccag tctgctgtct ctgggcctag ttcagcacca ggactcacct aagagttgca 35820
gtccttatgg cctagactgc ttttgaagtt tacttggaga caaagagcac tgtggccttc 35880
actggtgagg tttacaggca ctcaagttta gaccactggg attggtgatt cttctctggc 35940
tagggctgtt ttaaatcctc cctccgtttg cacatttcag ctgagtttga tctagtttgc 36000
ctttctgctc tgatttctgg ttcttatgaa ggtgtttttt tctgtgtaga cagctgttaa 36060
cttggtgtcc ttgcagaggg aatgatcagt ggagccttct atttcgccat cttgatccgc 36120
cgccatatat cattcttatc aatcattttc tgtttatgca cctgaaaata cactggtata 36180
caaaattaag atccttactt tcacagaatt tgtgttctaa tgggggaagt caataatcgg 36240
tggacaccaa tacatatata aattaaataa cacattaaaa ggtgttgagg acatgctggg 36300
catggtggct catacttgta atcccagcac tttggggggc cgaggcgggt gcatcacttg 36360
agatcaggag tttgagacaa gcctggccaa catggtgaaa ccctgtctct actaaaaata 36420
caaaaattag ctgggtatgg tggcaggtgc ctgtaattcc agctactagg gaggctgagg 36480
caggggaatc gcttgaagct gggaggcaga ggttgcagtg agctgagatc ctgccactac 36540
actccagcct ggacaacaga gtgagactct gtctcaaaaa aaaaaaataa ataaaaataa 36600
aagctgttga ggacaatgga ggaaaaggca gatcagagaa agaacattta caaaagccag 36660
agggagtgtg aagcaatttt aaatgaggtc agatttttgg ataatttcta ttgctatgtt 36720
tttaagttaa ccaatgtttc tttttgcaat gtctgatctg ttacattttt atttcagata 36780
ttatattgtt atctctagaa gttctattta gatctccttt ttatctttca attctctcct 36840
cattttgttc atattttgct ttatatccta gagcatattt ataatagttg ttttaaggtt 36900
cttgtgtgat agttatatca tttctgttat ttctgtgtct gatattattt atctattttt 36960
taaaacttta tgggtatagg tcatattttt tcatttcttt gaatgcctgg tgattatttt 37020
gaattttaca ttgttgagca ctggatgttg ttatattcct tttaagagca ttgagttgtg 37080
ttctggaatg cagttgagtt tttacagatc actttgatcc atttgagact ttcctttagg 37140
gtatatccag agtaacatct agtttagagt taatttgttt ttactactaa gatgtggctt 37200
ttctgaggat tttatccaat gtcctgtgta ttttggggtc tctccacact ggctgatgga 37260
aacacagggt agtctcagcc ctgtgtgagc tccaggaatt actcagctat tgcctatcag 37320
tgtttttttc ttcaactcca agtagtttct tccagctcat atccaaatca tacttaggag 37380
aagactgggg gggatcctct gcagatttcc aaagtgctct ccccactctc tgtatctccc 37440
tcttcttcat tactctgtcc cacaaattct aaccacctca acatccttaa attccaatcc 37500
attccccctt acctcaggta gaattctagg ttctgattgg ttttccctcc acgtgctgtg 37560
acctggaaat gacctccagg cagtatctct taggaagccc agttgtgtgg catctgttgt 37620
acaatgcctg aaaatgattc tttcatgtgt tttgtctggt tttcaacttg ttcacagaaa 37680
aaagcaattt gcacagcagt taattcttca cagacagaag cagaagttct accaactgca 37740
aaacaaccaa aacaacttgt taaaagacag tatttgtatg actggtcata aattacgtat 37800
agaagaatag agattttgtg agaaagatat gggcctgtac agaggggtga acttgcaaat 37860
gaccatcttg cttggggata gtgtctgttt tcctgatcct aatcactggg aaggattctg 37920
taatctctgt caaataaatt gcaaacacta ccacacatgg ccttgggtct actactgtct 37980
atgacataaa cagtttctcc ctagagactt agttgtgagg gtacaggggg aaggtagctt 38040
ttggaggggc ctggaagacc cttccctttg tgccttcgat tctgtatata tcttgtggtc 38100
agaagtctta ccattaccct ctctgataac tccccaccca ctttcccaat cactaaacac 38160
tttttgaaac cattcaactc tttcctttca atgattgagc ccttcattgt ttcatcagct 38220
cctcttgtgt gaatctctct gaatgtgtgc caagtttgca gtttaatgcc tgtcccatgt 38280
aggagcccaa tatcacggta tataaagttt ctacactgga tatccatgga ctgaagaggg 38340
gcctagcatt cagggttcca agccagtgag tttagcttat ccaagggtac ctctagaatg 38400
tgctcagaaa tttattccaa gtcagagttg catcccccag gactttaggc tcagatggac 38460
aaccccatca tatttacaga atccctcaaa gataatttaa gtttaagatt gtcagcccac 38520
ctggggtgca cagtgttgac cagggtttct taaccttagc actgttgaca tttggggcca 38580
gataattctt tgttgttcag accatcctgt gaattatagt atgtttagca gcatccttgg 38640
catctaccta ctagatgtga atagcatcct tctcttaatt ttgacaacca cagatgtctc 38700
cagaattgcc aaatgtcccc taaaggtgca aaattgcata gttgagaact actggtaaag 38760
aggcactatg gcatgccaag ctctagggag cccacagaag tgcacctctg ggaactaaag 38820
ctgaagaaac ccaagaggcc ccttggtatc ttcttggaag aagttagtcc agagtgtctg 38880
caccatgtgg agtgtatact gggatgacat tgaccttgga atgtaaactc ctgggattct 38940
tgcctctgca gatttggagc agggttttct tcttctctgc ttttcagttt acttatttga 39000
aaatgaggaa tggtgtttac atcacaaaac actgtagtga ggacaaaatg aggttttatg 39060
tatatataca cccatacata tacatataca cttcttccaa atgatataat aatatataaa 39120
cattgaatga ataatggttc aaatataagt gtacttattt gccactatga ttaaaagggc 39180
aatataggaa aaatacattt tcttctaatc catcatgttg taataatcct ccctgtggtt 39240
gcagtatggt tctgtgctag aaggcacaat aggaaatctc taactttaaa aaaaaagaaa 39300
agaaaaaata tctttctagc aattaaaatc tcaactaaat tagaatgcaa ataggttttt 39360
atatttgctt cttaattttg cattcaataa tctgactaga atatgcaata atttaaatgc 39420
cttgatggga gatagtggct tttagttctc ttgggatttc attgtaataa acctggtaaa 39480
taattcagga acatatgaga ggccaatgaa tggtcagcac ctggtgctat attatttgtg 39540
cctaagcaca cagactccaa agatggcact ctccacctgt cactgttgtt ctggcttaaa 39600
catgggccct gtgttcagtg gctattgaga taatagtaat ggatattttt gccttgtcca 39660
attttcctcc acaatcaaag aaaactgtgc taagctgttt aaaaaataca aagcagaagt 39720
ggcagcctct tttagattac cactggtaaa atttcaaatc tattttctct attaagggat 39780
tgattgtttt aaagaattag ggatatggct atcttttcta ctggtgctaa tttgagcctt 39840
tttgcctttc tgtctttgtt ccacaaggct gagcttctct ttagatcaca ttattcatat 39900
tgcaaggatc ttctgagaga aataacacca tcctctggcc agccactcac tctgcaggag 39960
ttcctagagc tccccagttt ctttccctat tgcctgagta gtctatctca cgcctgttag 40020
tctcacagtt taaatacaaa cacacaaaga ctcttgcagg cagcttgggt acctttcttt 40080
gaccccagcc gactggacat agagaacaag agctagagag aacaagagct agagtgaccg 40140
acagatcatg tgtggagaca gcatggggca cctgagccca gcaccatcca ggatcagaca 40200
gaacttaagc catgagctgc ctagaaagat cttgggaggg cactgggttt cccagtatgg 40260
aaaaaagaaa aatgtggctc acaagtctaa gctaaggtct ttacagtact gggccataaa 40320
caggatctga aaagaaactg cagaaaatgt tagatatgct ttatctttgt tttaaaaata 40380
ttatttacta taatggctta aaatatgttg atttaaatat atgatatttg atacctttgt 40440
aatatatata ataaagtgta taataaaata taactatata attaaaatag atgatatttt 40500
aaaacctctc taataaacca tttacgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 40560
tgtgtgtgtg tatacatgcc tttgtttaac aggtttaatt gctttccttt cttcaggaac 40620
cagagtgagg gtactcgaac agtgactgcc atctggtggt taaccagaat catcaccttg 40680
tgtagcctga tggttactaa gatgtccact cttgactcac atggcatgca ctcgcagcag 40740
gggaccagtt gaaggatgtc tgactttgga gggtcaccag ttgaaggatg tctgatgaag 40800
gagcctagcg aaataaccct ttgcttctac ctgaatgggt tgttcactct ggattctgag 40860
cctgcagcca gctccaaaat ggggcctctg aagaaaagat ttgagttgct cttgtgtctt 40920
agtcaaagat ctacatccct accagtgggt aaccaagact gtgaataagc acacaccaac 40980
aggggcatgt ggtgacatgg agcctgaaat aaactgctct gaattgtgtg acagttttcc 41040
tggccaggag ctggatcgga gaccccttca tgatctctgc aagacaacaa ttgtaagtga 41100
gcagccacag gatgccaggg ctgctcagat gtatgtggtg gtggtggtgt tggggaggag 41160
gaggtggagg gaaaggggga tgaggaaggg gaggagtggg aggagaaact gctcatgcag 41220
gatacatatt tcccagcact tggtgacgat ggggcagttt gtttttgacc tatagaagat 41280
ccttcattcc taacagctcc tccttattct gtcctcagac atcttcccac cacagcagta 41340
agaccatctc ttcattatct cctgtcctct tgggtattgt ttggactttt ctcagctgtg 41400
gacttctgct gatacttttc tttcttgcct ttacaattca ctgcaggaag aacaggtaag 41460
cagcccagtt tctcatcaca catagctcaa tcatgaaatc ccaaatgtta gtatcttttg 41520
gcagcacaag ccactatctg gtctcccact acaggattaa accacatgag acattccctc 41580
tgaaatagtc tacctgttga gaaggggaaa gatctaggtc ggtattgtgc taactactgc 41640
aagggtatcc aaagaagaga atgaagagtc tctctctata atggaggtac aatccttctg 41700
agaagatgag gtatctgtat ttaaaatgaa gaccatgtag aggattccaa aacaacacaa 41760
aaacttgagg acagcacagc agaaccagtc tgggtgagtt agggtttctg caaaagcagt 41820
gaagcactgc tacctggcta tttgctagat aattctggct gactagaaag tcatcagctt 41880
atcagggtaa gtatggctcc caggattcgc aaaagaagca aaatggtgac ttttttctga 41940
agggacttat agcaccttgc cttggatgca atttcatcct tcctcagggc ccatcccatc 42000
tctcccaccc ccacactgta ccctcatcct accacagccg tcccagggtg cctcatgaga 42060
agccctgctc cagccctctc cttagcccac agctgacttc tagatggagc ccacaatcag 42120
aaattaacaa cttcctcaaa ccagccaaac tcgtccagcc ccactccagc cttaccctgt 42180
gtggtgacca agcatgtcgt gctccattgc ctgtggattt gacactcaga tgagaattgg 42240
tcagttgcat tttgggatgc tgttttgcca tgttaggcat ggaggacgtg gaattgttaa 42300
gcagcagtga ttggttgttg ggtcagcctc agcatggtgg tgatacgtgg cactccaact 42360
agagtatacc ccagagactg cctcagccac ttttcattct gttcctcaag cacactacgc 42420
tgactcccat ctcaaggctt ttgtacttac tgttcctgta ctgttccctc tgcctggaag 42480
tcctcctcag atattcccat gactagttcc ttctcatctt ataggtcttg gctccagtgt 42540
cacctcttca gagacacctt ccctgatcat cctatctaaa gtagtatccc tacccatgat 42600
caccccctca tctcattcca tatcctatca gcctgtttta tgttccttat agcaagcata 42660
gtctgctatt accatatttg ttgatttacc tgttgattgt ctgtatcccc taccagaatg 42720
gaattctgtg aacacaggga ctttgcctgt cctcttgtgc ccaccactgt gtctccagca 42780
tttagaacag actctgggat ataataggtg ctcagtaaat atgcatccag tgatcctggg 42840
aggaaagaga tttaaatccc aacggtggct gctgccaaca aagtgactgg gaaaatcatg 42900
catttcaagg ttagagaact atggagtaca gtcttttcag ctgtaacatg tttctataat 42960
gcaaagtaat actcaattgg tattacccag ttggtaataa gaaaattatg tcattgattc 43020
atatgttact tttcccccag caaatcaata atttaaacat tcaggggcaa gctttctcac 43080
agctagtaaa ggaagcttta agcttggcag ttccttccct tggtgcaagt agtgtctggc 43140
ttaatggctt aagaacttgt gtcttcccta caagatgagg ctgtaggagt agatgaagaa 43200
gtggagaaga catttgcctt atgtttaaaa acttcagttg attgttaaag aaagcacaga 43260
tccagagcag atttttaatt ttttgacaat gttatctact ggagatgaat gcccctgagg 43320
acctgtgtct tgagatttaa gactgtagaa gttgactttg atcctgggta caaatgctag 43380
tggacattta ctgggtggta gtgttttagt tggaataatt aatattttat taatactctt 43440
gttacaaagt taactgtttt gagtgttatg accccatcct attttcccca cagtctatta 43500
tttttacata taattttgca gaatacaagg tttatcaagt atttatatat cctgttaaaa 43560
caggaacacc tgtaaacagc attatactag aaacccttat atttctttca ctctattaaa 43620
tattttgctg cctgttttgt ttgcagtggg agcatgactt ggcataaaga ataaaatatt 43680
aagaggtatt gtgaataaaa acacatttta caattaagtg gcttacaagg tcagacaagg 43740
aaagataaaa taacccagtt tcaaaagtgt tttattgaac aatacatttg ttaaaagatg 43800
cagcatcaca atcagatgct ttatttcgtt acaattctgt ggtctctaaa tttgggactg 43860
tgtgtgtgag tattcatgtg tgtgtatatg caagaaagga gaggaagaaa aatattttaa 43920
cacaataaaa ataatacaaa aatgtttaaa tccagttgca gatattgaat ttttataaaa 43980
atttcaaaaa ccagtaaaga taaagaaaac ttgaacacta tcaaccaact tgacccaatt 44040
gacatttata ttacctttca cccaacaaca gcagaataca tattcttttg aagtacacat 44100
ggaacattta ccaagatata tcatattctg ggccatagaa aaagtctcat taaatttaaa 44160
agggttcaag ccgggtgcag tggctcatgc ctgtgatccc agcactttgg gaagctgagg 44220
cggatagatc accagaggtc agcagtttga gaccagcctg gccaacatgg tgaaaaccca 44280
tctctactaa aaatacaaaa attagatggg tgtggtggca tgcacctgta gtcccagcta 44340
cttgggaggc tgaggcagga gaacccggga ggcagaggtt gcagtgagct gagatcatgc 44400
cactgcactc cagcctgggt aacagagcaa gactctgtct caaaaaaaaa aaaaattaaa 44460
ggattcaagt catataaact atgttttctg acaatgaaat taaaatggaa atcaataaca 44520
gaaagatctc tggaaaatcc tgaaatattt agaaactaca tagaacactt taatccatgg 44580
tcaaaaaaga aatcaaaagg aaaactagaa aatattgacc agaattaaaa tgaaaataca 44640
acctagattt gttggatgcc actaaagcag tattaggggg aaatctagag aactaaaccc 44700
catattagaa aagaagaaat gtctcaaatc catgacctca tcttccacct tacaaacaga 44760
aaaaaagagc aaatgagacc caaagtaagt agaagaaagg aaataataaa gatcaggtta 44820
gaaaataaaa taggaaacag aaaacaatag gaaaaaaaag tcagtaaagc caaaagctat 44880
gaagataagt aaaactgatc aacctctagc caaagtgatc agaaaaaaaa gaaataagat 44940
acaattaccc aaataaggaa tgggagaggt gacatcacta tagattctgt agatatgacg 45000
gataaggtaa tgttgtaaac aactatggta gatagcctct aagatgttct tcgatgattc 45060
ccacctcctt gtagtcacac tcctatgaag tcctctctcc ttgagtatga ggtgaactta 45120
ctaacttgct ttttagtgag atgtcgcttt tggcattagt tcacaaaaac tgtggcttcc 45180
accttagagc tctctcattg tcccactaac tcccactctg tgggaggcca gctgttgtgt 45240
tataagctgt cctgtaaaga ggcccccatt ggcaaggaac tgatgtttcc agcctgcagc 45300
cagcaagtac ctggggcttg ctaacagcca tgtcagtgaa ctttgaaaca ggtgacacct 45360
tgactgtatt gttgtgacac cttgactgta ttcttatgtg aaaacctgag ccacaggcac 45420
ccaactaagc tgtgacttag aaatattacc agttcaactt caaactcttc taaaaaaact 45480
gaaaataaag aagtaattcc caactcattc tatgagggca gtattaccct gatttcaaaa 45540
ttgaatagga aaaagaagaa ggagaaggag aagaaggaga aggagaagga agaggaggag 45600
gagaaggaga aggaggagga ggaggaggag gagaagaagg agaaggagaa gaagaagaag 45660
aagaggaaga ggaagaggag gaagaagaag aagaagaagg gaggaggaaa gctataggct 45720
aatatgtcct ataaacatag attcaaaatt ttaaacaaaa ttttaacaaa ttgagtatca 45780
ccaaatgtta aaaagagaat acatcattgt gacaacgtga ggtttatccc tggaatgtaa 45840
gctttgttta atatctaaag attgatcaat aactcatgac atttaccaac taaaaaagaa 45900
aactatatga tcatctcagt agatacagaa aaatttttga caaacttcaa catcaatttc 45960
tgataaagtc tcaacaaaca gcatagaaca gaacttcctc cccattgcgc agcacagctg 46020
ctgtggcaga ttgtggccag actgcttctt taagtgggac cccgatccat cccccctcac 46080
tgggcaggac ctccttgtga gaatttcagc aactccagcc agggttttat ggacagaact 46140
ctgatctctc tgggacagag cccctcaggg gaagggtggc cacagtctct gtggttcagc 46200
caacttagcc tttcctgcct gctggctctg gagagtctgg gcagtctgga caaaagggga 46260
tccccccagt gcagtgcacc cagtccccca aggggcagcc agactgcttc ttgaggcagg 46320
tccctgatcc cattcctcct gactgggtga gaactcccaa agggatcccc agacacctct 46380
tacaggagtg tttgggccag cgtcagtttg gagcaggcag ccatctttgc tgttttgcac 46440
cctttgctgg tgatagtgat acctccaggt gcagaaggga cccaggtgat tagggtctgg 46500
ggtggaccac tagcaaacca cagcagccct gcagaagagg agcctgactg ttaaaagaaa 46560
aacaaagcag caacaacaac ataaacaaaa aagatcccca aaaaaaccca ttgaaaggtc 46620
agcaacctca aagactgaag gtagataagc ccacaaagat aagaaagaat caatgcaaaa 46680
atgctgaaaa ctcaaaaagc cagagtgcct cttctccaaa tgattgtaat acctctccag 46740
caagggcaca gaactgggct gagactgaga tggctgaatt gacagaagta gccttcagaa 46800
tgagggtaat aacgaacttt gctgagctaa aggaacatgt tctaacccaa tgcaaagaag 46860
ctaagaatca tgataaaaca ttacaggagc tgataaccag aatagccagt ttagagagga 46920
acataaaaca cctaatggag ctgagaatca caacgtgaga acgtcacaat ccaatcacta 46980
gtgtctatag ctgagtagac caagcagcag aaagaatctc agagcttgaa aactgtcttt 47040
ctgaaataag acaggcagac aagaatagag aaaaaagaat gaaaacaaac aaaacctcca 47100
agaaatatgg gattacgtaa aaagaccaaa cctacaactg attggagtac ctgaaagaga 47160
tggggagaat ggaaccaaat tggaaaacat acttcataat gtcatccagg agaacctcgc 47220
caatctagca agacaggcca acattcaaat tcaggaaatg tggagaaccc cagtaagata 47280
ctccacaaga agatcaaccc caaaacacat aatcatcaga ttacccaagg tcaaaatgaa 47340
agaaaaaatg ttaagggcag ccagagagaa aggccaggtc atctacaaag ggaagcccat 47400
cagactaaca gtggacctct cagcagaaat cctagaagcc aaagaaactg gaggccaata 47460
ttcaacaatt tttttatttt ttgttttttt gagactgagt ctcgctctgt cacccaggct 47520
ggagtgcagt ggcgcgatct cagctcactg caagctccgc ctcccgggtt cacgccattc 47580
tcctgcctca gcctcccgaa tagctgggac tacaggcgcc cgccaccgcg cccagctaat 47640
tttttgtatt tttagtagag acggggtttc actgtgttag ctaggatggt ctcgatctcc 47700
tgacctcgtg atctgcccac ctcggcctcc caaagtgctg ggattacagg cgtgagccac 47760
tgcgcccggc ctcaacattc ttaaagaaaa gaatttccaa cccagaattt catatcaggc 47820
caaattaagc ttcataagtg aagaagaaat aagatccttt tcagacaagc aaatgctgag 47880
ggaattgtta caaccaggac tgccctgcaa gtgctcctgc aggaagcact aaatatggaa 47940
agaaaaaact taccagccac cacaaaaaca cactgaagta cacagaccag tgacactatg 48000
aaggaaccac ataagcaagt tggcaaaata aacagctagc gtcatgatga caggatcaaa 48060
ttcacacata acaacactaa ccttaaatgt aaatgggcta aatgccccca ttaaaagaca 48120
gagaatggca agctggccaa agagcaaaga cccgtcagca tcagcaaaca cccagatgct 48180
gtcttccaga gacccatctc aagtgcagag acacacatag gttcaaaata aaggaatgga 48240
ggaaaattta ccaagcaaac ggaaaacaga aaaaagcaag ggttgcagtc ctagtttctg 48300
acaaaacaga ctttaaacca acaaagataa aatagacaag ggcattccat aatggtaaaa 48360
ggctcaattc aacaagtagc gctaagtatc ctaaatacat atgcacctaa tatgggaaca 48420
accagactca taaagcaagt tcttagagcc ctacaaagag acttagactc ccacacaata 48480
atagtgaaag actttaacac tccactgaca atattagaca gatcattgag acagaaaatt 48540
aacaaagata ttcaggacct gaactaaact ctagattgaa tggacctgat agttatctac 48600
agaactctcc acccaaaaac aacagaatat acattctttt catagccaca tggcactcta 48660
aaattgatca tataatcaga agtaaaacac tcctcagcaa atgcaaaaga actgaaatca 48720
taacaaacag tctctccaac cacagcacaa tcaaattaga actcaagaat aagaaattca 48780
ctcaaaacca tacaactaca tggaaatgaa caacctgctc ctgaatgact cctgggtgaa 48840
taatgaaatt aaggcagaaa tcaagaagtt ccttgaaact agtgacaaca aagagacagt 48900
gtaccagaat ctctgggaca cagcgaaagc tgtgttgaga gaaatttata gcactaaatg 48960
cccacatcaa aaagctagaa agatctcaaa tcaacaacct aacatcacaa ctaaaaaaac 49020
tagacaacca agagcaaaca aatcccaaag ctagcagaag acaagaaata accaagattg 49080
gagtggaact gaaggagata gagacacaaa aaaaaatttc aaaaaaccaa caaatccagg 49140
agctgatttt ttttgaaaaa aaaaaagtta ataaaataga ctgttaccta aactaataaa 49200
gaagaaagag aagaatcaaa tagacacaat gacaaatgat aggggggata tcaccactga 49260
cctcacagat acaaacaacc atcagagaat gctataaaca cctctatgca cataaactag 49320
aaaatctaga aggaatgggt aaattcctgg gcacaaacac ttgcccaaga ctgaaccagg 49380
aagaaattga atccctgaat agaccaataa tgagttctga aattcaggca gtaacaaata 49440
gcctagcaac caaaaaaagc ccaggaacag acgaatttac agctaaattc taccagaggt 49500
acaaagagga gctggtacca tttcttctga cactatttca aacaattgaa aaggagggac 49560
tcctccctaa ctcattctat gagaccaaca tcatcctgat accaaaacct ggcagagaca 49620
caataaaaaa acaaaacctc ggacaaatat ccctgatgaa catcaataca aaaatcctca 49680
ataaaatact ggcaaaccaa atccagcagc acatcaaaaa gcttatccac cacgatcaag 49740
ttgacttcat ccctgagatt caaggttggt tcaacatatg caaatcaata aacgtaactc 49800
atcacataaa ccacatgatt atctcgatag acacagaaaa ggcctttgat aaagttcaac 49860
atctcttcaa taaactctca ataaactaag tattgaggaa tatacctaaa aataacaaga 49920
accatctatg acaaacccac agccagtatc atactaagta ggcaaaagct ggaagcattc 49980
cccctgaaaa ctggcacaag acaaggatgg cgtctctcac cacttttatt caacctagta 50040
ttggaagttc tggccagggc aatcaggcaa gagaaagaaa taaagtgtat ctaaatagga 50100
agagaagaag tcaaactgtc tttgtttgca gatgacatga tcctatgtct agaaaacccc 50160
atcgtctcag cccaaaacct tcttaagctg ataagcaact tcagcaaagt ctcaggatac 50220
aaaatcaatg tgcaaaaatt gctaacattc ctataaacca acaacaggca agcagagagc 50280
caaatcatga atgaactccc attcacagtt gctacaaaga ataaaatacc taggaataca 50340
gctaacaagg gaagtgcagg gcctcttcaa ggagaactgc aaaccactgc tcaaggaaat 50400
cagagaggac acaagcaaat ggaaaaacat ttcatgctca tggataggta gaatcaatat 50460
tgtgaaaatg gccatatggc ccaaagaaat ttatagattg aatgctattc ctattaaact 50520
accattgaca ttcttcacag aattagaaaa aactattata aaattcatat ggaaccaaaa 50580
aacagcccca atagccccaa tatctttttg cttaggattc taagcaaaaa gaataaagct 50640
ggaggcatca tgctacctga catcagactg tagtacaaga ctacggtaaa caaaacctca 50700
tggtactggt acaaaaacag atacatagac caatggaaca gaatagagaa ctcagaaata 50760
agaccacaca cctacaaaca tctgatattc aacaaatctg acaaaaatga gcaatgggga 50820
aaggactccc tatttaataa atggtgctgc aaaaactggc tagccatatg tagaaaattg 50880
aaagtggacc ccttccttac accgtataca aaaattaact caagatggat taaagactta 50940
aatgtaaaac ccaaaactgt aaaatcccta gacgaaaatc taggcaatac cattcaggac 51000
atagacattt catgacgaaa atgccaaaag caattgcaac aaaaccaaaa attggcaaat 51060
ggggtctaat taaagagctt ctgcacagca aaagaaactg tcatcagagt gaacagacaa 51120
cctgcagaat gggagaaaat ttttgcaatc tatccatctg acaaaggtat aatatccaga 51180
atctacaagg aacttcaaca aatttacaag aaaaaaataa ccccattaaa aagtgggcaa 51240
agggcatgaa cagtcacttc tcaaaagaag acatacatgc agccagcaaa catgaaaaaa 51300
agctcaacat cacagatcat aagagaaatg caaatcaaaa ccacaataag aggtgggtgg 51360
gtcacttgag gtcaggagtt caagactaga tctagaatca gaaataccat ttgacccagc 51420
agtcttatta cggggtatat acccaggaat ataaatcatt ctattataaa gatacatgca 51480
tgcataactt cactgcagga ctattcacaa taacagagac atggaatgaa cccaaatgcc 51540
catcaatgat agactggata aagaaaatgt ggtacatata taccgtggaa tactatgcag 51600
ccataaaaag gaataagatc atgtcctttg cagggacctg gatggagcaa actaatgcag 51660
gaacagaaaa ccaaacactg catgttctca cttataagtg ggagctgaac tatgagaaca 51720
catagacaca tatggggaga acaacacaca ctggggcctg ttggggaagg ttgggggagg 51780
gagagcataa ggaagaacaa ctaatggatg ctgggcttaa tacctaggtg atgggttgat 51840
ctgtgcagca aaccacctgg cacatgttta cctatgtaac aaacctgcac aggtaccctg 51900
gaacttaaaa gttaaaaaaa ttttaaaaag aagagaactt cctcaacctg ataatgtgca 51960
tctataaaaa aacctatacc taacatcatt tttaatggta aaagaccgaa tcctttccca 52020
ttaggatcag aaagaagaca agatatccac tctcacgact tctattcaac actggaggtt 52080
ttagccagtg caataaggta agaaaaataa acaaaagtca cctacttttt aaaaaaagta 52140
agaatgaaaa tatttttacc ctcagatgac ctgatcacct atgtagaaaa tccagtgaaa 52200
catttaaaag gaagaaacag ggcaggcatg gtagctcacc cacccaaagt gtaatcccac 52260
cactttggga agctgagaca gaaggatcac ttgaggtcag gagttcaaaa ccagcctggg 52320
cacagagtga gaccttgtct ctataaaaaa ttaaaaaatt agctgggcat ggtggtgcat 52380
agctttagac ccaaacactt agaaggctga ggtgggagga ttgcttgaat ccaggagctt 52440
gaggctacag tgagctaaga ttgtgccact gcactccaaa ctgggtgaca gagccagacc 52500
ctatctctaa acaaaacaaa actactagaa ctaatacatg agtttagcaa ggttgcagga 52560
tacaagatca atgtacaaca ctcaactgta tttccatata ctaacaacaa ataattgaaa 52620
aagtgaaatt aaaagcaata ccatttacaa cagcatcaaa tagatgaaat atttagggat 52680
aacctaacaa acaatgtgaa atgcctgtac actgaaaact ttaaaacatt gctaagagaa 52740
tttttaaaaa tctaaataaa tggagataca ttgtgttgct gggttggaag actcaatatt 52800
gtttaaatgt cagttcttcc ctagttgatt tatagactta atccaataac agtcacattt 52860
cctttttttg tataaattga caaactgatt ataaaattca tgtgaaaata tgaaggacct 52920
agaatagaca aaacaacttt taaaaagaat gaagttggaa gactaggacc acctgatttc 52980
aagacatatt acaaaactaa cagtaatgca gacagtttgg tactgggcaa ggatagacat 53040
attcatcaac agaacagaat agactacaga aataaatcca catgtatatg gtcaactgat 53100
tttcaacaaa ggtacaaagg caattcagtg gagaagggac agtcttttca gcaaatactg 53160
ctggaacaaa tgtatatcca tatgcaaaaa tgaactttga tctagctaca tgttacacca 53220
tattaagaaa ttaactcaaa atggatcaca gacctattta taaaacctaa acctgtaaag 53280
tttataaaag aaaacatata agaaaaattt tgtgaccttg gaataagcaa atatttctta 53340
ggtacaatac caaaagcatg gtccataaaa gaaaacactg atgaattaga ctttttaatc 53400
attaagaaca tcttctcttt caaagagaat cttaagagaa tgagaaaaag ccacagacta 53460
gaataaaata tttgaaatca tatatctggc tgggtgtggt ggctcacgcc tgtaatccca 53520
gcactttagg aggttgaggt gggtggatca cctgaggtca ggagttcaag accagcctgg 53580
ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa aaaatgagcc atgcgtggtg 53640
gaggcacctg taatcgtagc tactcaggag gctgaggcag gagaattgct tgaactcagg 53700
aagcagaggt tgcagtgagc caagattgct ccattgcact ccagcctggg tgacaacagt 53760
gaaactccat ctcaaaaaaa aaagaaaaaa aaaaactcta aaaacgcaat acagtggtgc 53820
tcccttatct gtggttttgc tttccatggt ttcagttacc tgtggtcaac catggcctga 53880
aaatattaaa tggaatattc cagaaataac caattcatag gttttaaatt gtacaccttt 53940
ctgaggagca tggtgaaatc tcatgctgtt ccactctggc ccacccagga cacaaatact 54000
ccttttgtcc aacatatcca tgccatatac actacctgcc tgttagtctc ttagtagcca 54060
tcttgattat cagattgcct gtcatggtat tgaagtgctt tgtgttcaag taacccttat 54120
tttgcggtgg ccccaaagtt caagagtaat gatgctgaca tattgttata atttggtatg 54180
gtttggctct gtgtccccac ccaaatctca tctcaaattg taatcctcac atgtcaaggg 54240
agggacctgg tggaaggtga ttgggtgatg ggggcagttt ccctcatgct gttctcatga 54300
tagtgaggga gttctcacaa gatctggttg tttgttaagt gtctggccct ttcccctgca 54360
cactctctct ctcctgccac cttgtgaaag tgtgtcttgc ttcccctttg cctttcgcca 54420
ttattgtaag tttcctgagg cctccccagc catgcagaac tgtgagtcaa ttaaacctgt 54480
ttttctttat aaattattca gtctcatgta gtacctttat agcagtgtga gaacagacta 54540
atacataatt gttttattat tagttatggt tgccaatccc ttactgtgcc taatttataa 54600
attaaacttt attataggta tatatgtata agaaaaatca gtatatatgg ggctcagtac 54660
tatccatggt ttcaggcatc cactgggggt cttggaatgt atcccccctc agataagggg 54720
gactattgta ataagaaaac aattcaatat tttaaaatgg gtaaaagatt tcaacagata 54780
cttcaccaaa gaagatatat ggatgacaaa taagcatatg aaaagatgtc caataccatt 54840
actcattaag gaaatgcaaa ttaaaactac attaaaatac cactacacac tcattagaat 54900
ggctaaaatt aaaaagactg agtaaatccc atgttggcac acactgctga ggagaacata 54960
atttggtcca accacttcac tttggaaggc agtctgggag attatttatt tatttattcc 55020
attcctggct gatttttttt atagaaatag agtttcacta tgttcctcag gttggtctca 55080
aactcctggg ctgaagcaat ctgcctgtct tggcctctca aagtgctagc attgcaggca 55140
tgagccaccg cgcccggcca tggcagtttc tttaaaagtt cagcatatac ctatgatgtg 55200
atctagctat gccactctta ggtttttacc caagagaaat gaaactgcat gtccatacaa 55260
agacttgtac gccaatgttc atagcaactt tctttgtaat agccaaaaac tggaaatagc 55320
acaaataccc attagcaagt gaatggctaa acaaattgta gtatatccat acaatagaat 55380
cctgctcagc aatttaaaac atgaattatt gatacttgga agaacaaaga tgaatctcaa 55440
aataattaca ctgaatgaaa gaagccaggc aaaatgacta catgctatgt aaatccaatt 55500
ccacaaagtt ctataaaact aaactaatct attgttaact aatctgtagt gacagaagca 55560
gatcagtcgt tgcctgtgga tgagtagggt tggcaaagag tcaggaaagg aggatgacaa 55620
aggggcatgt ggaagctttt tggggtgatg gatatgttta taccttgatt atggtatttc 55680
acaggtgcat acatatatca aaacttatca aatcatgtac tttaaatatg tatgtcatgc 55740
actttaaatt gtgtgccagt tataccttaa taaagctagt aaaactatta tacattctta 55800
tttttctgag caggttctca tggagaacaa aatacaccat acctagtgtt cgttttcttt 55860
tttttaatta attaattaat tgatttttat tagtgttcat ttcaaaggac cttgctaggt 55920
gtcctaaaac ctatctgatg actttgcctg atactgatga ttttattatg attttaaaaa 55980
atatttttag tagagacggg ttttcgccat gttgggcagg ctggtctcga actcctgacc 56040
tcaagtgatc ttcccacctc agcctcccaa agtgctggga ttacaggagt gagccaccat 56100
gctcagccaa tactaataat tgatatggga gaatgttttg tttttcctag attcctcatg 56160
cagcttaata aggaccataa taacttaact cttagaacaa aggagatatt tcaggcccaa 56220
agggaagcac atctggtgcc tcctctgaaa ttcacaaaat aagggcgttg ttgtaagttc 56280
tgcatgaagc taaacttgtt caaagtttat aagttcaaaa gtaaataaaa ggactatctt 56340
ttattctgag accttatttc aatatcactt gtgataatga ttatagatcg tagctgttat 56400
ttacatattg ctacttctca gggttaaagg tggcatttcc acagcagtat ctgggatttt 56460
attgcctatg aaatcaagaa ggtagagtaa caagaattgt gtagggtatg agcttttacc 56520
ttacatgcaa gttaacaagt tagcctggta atgtttgatg gatgttagct aaagacatga 56580
gactcttggg tcagagaaaa aacacttgat tactcatggc aaaagcagta atcagaactt 56640
aatattgagc ttttactggt ttccatgccc cacgtgccat gaggggaatg aaagtcccat 56700
aatggatgtt tatggatgtt tgcacacaca cagtgggcta ccatttaagg agaggaatcc 56760
tgagcctggt aagtccactg cttttatagt gagttgtaac aagcctgttc tttgtctagg 56820
ggaagatgtt acctgatccc tcaaggttgc tcattacaaa cacaaccctg agaaatggcc 56880
tggataaaga gcagtcagag ccttgcttct tggcatacct gacaagaatg cacagagctg 56940
ctcagggccc ctggtaggtt tgcctcccac actagggact gtgcatggag gcacctgcca 57000
cttctgcctg catcctgggc tagcgtgaca gtcagagaca cagacaccag tgaatggctg 57060
aaatatgttc ctgtggtctt ctcactccac tacaacttcc ttcccagtta gggtccccat 57120
gcaggccctt tgagctgcac ctggcagagt tgagttacat actttcatgt accctgctga 57180
gtttgtcttc tttgccttca gaaattccaa catactacat gagtcatggt tcttggtatt 57240
attgttatac ccttctcaga atctctctga ctccccagat ttcacatcgt tttccatttt 57300
tgtaaaaggc ctcaaggtct ccatgctatg gagaagagtt atactcatct tttctttatt 57360
cttgcattcc tgaaagcctt acattagcat ccaagtgagg tttctctatc aatatcaaca 57420
gtaaatattt agtgaactaa acacctacta tgctcagcat aatgtataaa atatgattta 57480
agggttcctg ggagcttcaa atgcatcacc tgggtgcaaa aacatgagga aaccaaaaag 57540
tacattctgg tggttttttt aatagcattt aaaaaataat gccttgctgc agggatagga 57600
gctgtgctgc tttcatatca attctgttct ctttgtggtt tgagaaactg gagctgaagg 57660
gaaggtgatt gggaataaaa gaaagcagta ctgatttttc tggctaaaag aaagtttgca 57720
cactgtcatg cactattaga atttctggga tcttctttat aatccccggt ttgatggtta 57780
ttggccaaga aggaagaagg ggagctagtc aggcctagaa taattaccag ccatacagca 57840
taatctgggg ctagtgttgc agggtcaagg actgaatgag gcagagtgac caggagcaga 57900
tcctgcaagg ccttgaccaa aaaggaagct aaggttcata gaaggaaaat attgtattga 57960
tcatcaattc tagaggattg ggcatagagc caaaaatagg aggtgtatca tgagatcaaa 58020
agccattggt ggccaagcgc gatggctcac acctataatc ccagcacttt gggaggccaa 58080
ggcgagcaga tcacttgagg ccaggagttc aagaccagcc tggccaacat ggcaaaaccc 58140
tgtctctacc aaaaatataa aaattagctg gccatggtgg cacatgcatg taatcccagt 58200
actcaggagg ctgaggcagg agaatcactt gaacctggga ggcggaggtt gcagtgagcc 58260
gagatcatgc cactgtactc caacctgagt gacagagtga gaccctgtct caaaaaaaaa 58320
aaaagccact ggtatgtagg aatggtgcag gaaaaaagtg caaagcagaa atgaggtgaa 58380
aatatataga actatgaaca ggaatgaggt ctttcttgag tactggctgc cagatggagt 58440
acgagtgggt cagcagaagt taatgaggta ggttaaaagt taatgcatag gaatagtttc 58500
tgcacagtct tctgatgctg tccatcctgc agtcaggcct atatcaatat cagccctaga 58560
tgaagtggtc acaccctcct ttgtgcacct actgttacaa atagtcatgg ctgtcattac 58620
tccatcacag ctgatggcac ttactaggtt gagagaagcg gggctctgtc tcccttacca 58680
tacagtgagc tccttgagtt tattcatctt tgtgtttcca ttgtgcctgg actgcgcact 58740
gtttcccgaa tgaacaaatt aactggccta gaatatatct atgatgataa aggtcagttc 58800
ttagattatt gttttcattc tttaactgtt taagataatg tcaactctat gtaaaaattg 58860
tgccctaggt aagcagttgc tttttattat tattctctct ctttcttgat ggttactccc 58920
tctaggagcc caaagcatga cgtccagagc cccagattcc cagccatcct ggttgtgacc 58980
cttcattctc aactttcatt tcaatcttag tatgccatga aaagccgtct gcttttgaag 59040
cactatcagc cacagagttc tgtactttta gaaggccttc tcatagtcag attctcacaa 59100
atatacctat tgtttcaata aatatttatt gaattggcca gcaatgtttc agatactgtt 59160
ctaggtgctg gggttacatc aaagaacaag gtaggcaaaa tcactaccct cgtggacttt 59220
gctttcctgg agggggaata ggcaggacat aaaataaatt gtaaactatt cgggatgtta 59280
gtgatcagag aagaaaagta aaacagggac agtgaatggg gactgtcaga gtggtagttg 59340
ctattcaaga tcatttgacc aaggaaggcc tcgctgagga agtaacattt gagaatagac 59400
ttgaaaggca taaaaaaaca agtcattagg taaaaaccat tccaggcaga aggaacaaat 59460
aatgcaaagg gccagggatg gaaacatctg tagtgttcag gggaaagcaa ggaggccagt 59520
gtgactggag cagagtagat taggcaaaga acaggagtag ataagatcag caaggtaatg 59580
ggtgccacat cacgtaaggt cacacaggac agtgtaatga ctttggcttt tactctgtta 59640
tggggagcca ttgcaggatt gggagctgtg aaatggcaca ccttgcttac atctaatagg 59700
aaatctgctg ctgcattgag aatagacctt taaattttaa aagagatatc tatggcatta 59760
ccttaaataa agtcatgctc cttggagtgc ctcaattcat gtacattaat gggtaaaagt 59820
ggaattcaag aaaccctgga aatgtatggg ggagtcctct ttgtttctcc tctgctcatg 59880
tctggtgggt gagcactaac gccatctctt cctaagcgag ggctccctag cagagcaccg 59940
tgcacatgga ttcttcctat gctctgcatt ctttgccaca gggatgccat aatttggcaa 60000
tatgcagtag agactgcctc aagaggcagt tcccttcttt atctaagcca agagaaattt 60060
ggttctgcaa gtaacaagta attactgctg atgacattcc ttgtacacac ttgaagagag 60120
cgtggaccgc aaaataaaaa ctggagcaaa aagggactat cagataatcc agattaaaga 60180
ttggaaagga ggaaaacaca ttatttacac atacaacact tgattttatg agtagagaac 60240
acaacttatg tgtatgtacg ttgtacactt gattatatgt gtagagaatt caaaagtgtt 60300
cagataaatt atttagactt aaaaagagac aaataatttt gggaaggtga tagtggcagt 60360
agtagcatag gttttagata ttcctgaatc tccacataaa aacagcaact agatagaaga 60420
cacaaaactc atgggcaaca aaataaaatc catttacaag aaaattagat gatgaggtat 60480
tcttatgatc ctcaaaatat aaccggttgg ggaaagacca cccacagcca caagagctgt 60540
gttatttgtg tctacgtagg agaaataaga gagaggcaat ggacatctga cagacctgag 60600
aacagagaac tcaaaatagc ccaaaggtat tcactggaaa gcatgggtgg ggcaatttga 60660
gatcagcagc tgaaacttaa taaggggtga gtgcaaggga tccacctctg gaaggtctaa 60720
aaggaatgca gcagtctagc tgctgtgaaa tttctagact gatctggtgg ggctcccttc 60780
caagatagga tctcatgaag aagagaaact gtggggagta ttgagctcaa aattgagcag 60840
aatgaagaca atacagatga agaaggaaga ggaatatcca aatgaaagca tatcagagtc 60900
aggaaatctc cttggaaagc aagccagagt attttttaac accatattaa tacaatatag 60960
caaaggaacc atgtgaagtt agaaaagcta tctgaaccaa atgtcttttt aaaatcacat 61020
aaaaactaaa ttcacaccca caaaaatcta cagcaggaaa atatcaaggc caaatccaac 61080
acaacattat taacctaaga aagagaataa ggggaatatc tgcagacaat gaaagcatgc 61140
caaaaagata tgattgaaaa tagattgaga ccctaatgta ctatttcagg tgcattcaaa 61200
gacattgaag aagtcatata agacatagaa aagcaacata aatcaaatta ggaagctcag 61260
aaatgagaca attcaagaaa aaattagaaa taaacatcta aaaatgaagg ctgatctaga 61320
aggaactcaa caacaaatga atacaacata attctttaac ataaataaaa ggtagaaagg 61380
aagaaaattt tttaaatgga atgaaaaaag atttttaaaa agttttgaaa gaaaacaaca 61440
aatattgaaa ataggcaaaa aagatcaatt tatcaataat aagagtccct gaaaaagaaa 61500
ataaaagcaa ggaaagaaaa caagtataaa acaaacaaaa ccctctaatt taagaaaact 61560
gaaaatttga aactacgtat ggaaagaaca cactgtgtac ttgagtatat cataatgact 61620
aagttcagca gagttgttgg atgaaaggtc tatgtgtaaa caccatttta tgtaacattt 61680
aaacaaattt tttagatcat ttaaaacagc ataaaaaata taaaatccta tttgtgacgg 61740
ctttctagtg tgtcaacttg actaggccaa actacatttc ctagaattct ctttcttgta 61800
tgttttctga ccacaaagga gattctttct agatttggaa agctaaggga agttccagcc 61860
atcttatagc acacacattg ttgcgaacct gctgatccac ctactggggt gaagcagagc 61920
tggacatgca attgctctac cttcccctgg accctccatt aacttgtcag gcccctgggc 61980
caggtgtgtg tgattagctc cacgacaaag ggccacagct tctgcaggat atactcatta 62040
cctagatcag aggcaacaat aactgacatg ggtttcagtc tcttcacagg ggtgtgagca 62100
tgctctaatc tcttgatttt ccctcctgac tgcctgcctt gtagacttca agctctagca 62160
tcagatgtgg agacaacagc cttacagaga ctgcttaaag agctcccaaa attgcataac 62220
tcaactgcct gtgacacatc catatatctc tttttgaatc ctggctaata cagtaggaaa 62280
agatatgcat tatctctata tagaaaatca taaaatattt tgagaggaat taaattctat 62340
attcattgat cagaagactt aatattgtaa aaatatcatt tctccccaga ttgatatata 62400
ggttcaatgc aatagaaatt ccaacaactt gcatatgtgt gtgtgaaact tgacaagcta 62460
aatctcaaat ttatacggaa attcaaaggg ctaaaaatag gctggaaaga aaaggacaag 62520
ctgggcgcgg tggctcacgc ctgtaatccc agcacttttg gaggccaagg cgggcagatc 62580
acatgaggtc gggagttcga gaccagcctg gccaacatgg cgaaacaccc tctctactaa 62640
aaatacaaaa atttgccggg catggtgggg ggcgcttgta atcctagcta cttaggaggc 62700
tgaggcagga gaatcacttg aacccaggag gcagaggttg cagtaagcca agatggcacc 62760
attgcactcc agcctggatg ataagagtga aactctgtct aaaaaaaaaa aaaaaaaata 62820
ggacaaagtg agaggatttc ttcttctgga tatcaatatt tactataaag ctagtaatta 62880
aaacctgcta aatatggtat tggagcaagg agagacaaat agatcaatag aacagaatag 62940
agagaatcca gaaagagtca aggatatata gatgcttttc aataaatggt gcagggtcag 63000
ttggctatcc acatggagaa aaaagtgcaa cctgaatcca cctcaacaaa attacttcca 63060
ggtgaactac tgaaatggaa aacaaaaaaa cttcaggaaa gtcatagaag agagtatctt 63120
tatgaactag ggacatgaaa atatgttaaa cagaacacaa caagtattat tcataaggga 63180
aaatattgtt aaattgctct acattcgttc aggagcagcc tgggcaacat ggcaaaatgc 63240
cgtctctgct aaaaatacaa aaatacagcc aggcatcgtg gtgcatgcct gtggtcccag 63300
ctactctaga ggctgaggtg ggaggatcac tggagcctgg gaggcagagg tcacagtgag 63360
ctgagatcac gccattgcac tccagcctgg gtgggtgaca gaggaagacc ctgtctaaat 63420
tgaaaaaaaa aaaaaagctc tacattagaa attgagaact tctgttcatt aaggacatca 63480
ctaaggaaaa aggcaagcca tagactggga caatgtattc acaatgcata tgtcatcaaa 63540
gaatctttat tcagaataaa aaagtgggaa tctatatgaa aacatagaaa atccactttt 63600
ttaaaaatgt gcagtcttat gtttatcaca gcactgttca cagtagtaaa gtcatagaat 63660
ccatctaagt gtccatcaac agatgattgg attaaaatgt ggtatatttt tgccatggaa 63720
tactatacac ctataaaaat aaatgaaatt atgtcttttg cagcaatgtg gatggaactg 63780
gaagccatta tgcttactga aatgactcag aaacagaaaa tcaaaaacca catgttctga 63840
ttgataagtg ggagctaaac agtgggtata cacggacata caaggggcat aatagacact 63900
ggagactcca aatggtggga ggatgggagt gggtgaggga tgaaatacca cctttcaagt 63960
acagttcagg tgattggtac acttaatgcc cagatttcac cactgtgtaa tatatccatg 64020
taacagaact gcatttgtat ccctaaatcc ataaaaataa aaaaatttaa tttcaaaaaa 64080
taaaaaatgt gcaaaagata tgaacaggta catcacaaaa gaacaaatcc agatagccaa 64140
taaacaaatg aaaaagggct caacttcatt agtcatcaga gaaatgcaaa ttaaagccac 64200
agtgtgataa tactacatac tcacttgaat gtctgcaatt aaaaaaaaga ctgacaaaac 64260
caagtgttga gaaggatgta gaacaactgg aattctcatg catagtgtgg aagtgtgcat 64320
tgatacaatc acttttgaaa actgtttagc agtatctact aaacttgaac atattcatac 64380
cctgtgtcct agcaattcca gcaaaattgc atacatatat tcaccaaaat aatgcactag 64440
aatattcata gcaacactat ttgtaatagg cccaaattgt aaactgtttg aatgtccatc 64500
aacagttata atatctattt ataatgtcca atatatcaca gtatactcca tgccacaata 64560
tagatggctc tcacaaaaat aataaatagt gttgagcaaa ggaagccaga aaaagagatt 64620
ataccctatg ttactctttt tacatgatgc acaaaaacag gcagagctaa tctaagatgt 64680
tagaagtcag attgggtggg tggagaaaag ggagaataga gcaagaggaa gacttctgaa 64740
gcactaataa tatgtttttt gacttgcatg ctggttgccc aggtgtgtca gtttttgaaa 64800
attcagtgaa ttatacattt atatatatgc atttttgttt atgcatattt ttcttcagca 64860
aaagtttaaa aaataatctt tgggcttcct gaaaagataa aaaggaaacg tttaaaggat 64920
acatgtcaat tttttagcag agacaaaatt tttaaatact attttctgaa aaaaaattct 64980
ccctcacagc tttatattta ttattaatat tgaaggatat aatgaatagt tttactgtaa 65040
atgcagaagt aaattttata agacttgttt atggcaccat taggaatagt ttttaaaaat 65100
cagaacttgt gtttatcaaa agacactatt aaatgacacc aaaagcacaa gtaacaaaag 65160
aaaaatgtgt ttaatatcat caaaattaaa aatttctggc caggcaccgt ggctcacgcc 65220
tgtaatccca gtactttggg aggccgaggc aggcagatca caaggtcagg agtttgagac 65280
cagcctgacc aacacggtga aaccccatct ctactaaaaa tacaacaaat tagccaggca 65340
ttgtggtgcg cacctgtaat cccagctact tgggaggctg aggcaagaga atcgctcgaa 65400
cccaggaggt ggaggttgta gtgagcgaga tcttgccact gcactccagc ctgggtgaca 65460
gagcaagact ccacctcaaa aaaaaaaaaa aaaaaaaatt ctgtgcttca gataacacca 65520
ttaagaaagt aaaaagaacc tacagaatga agaaaacgtt ttcaaattat ataatagacc 65580
tgataaggga ctcacatcta gatatataaa gaatgcttac aactcaataa tacaaagaca 65640
aataaaacaa tttttaagtg ggcaaagaat ctgaatagaa gtatctcaaa aaagatatat 65700
gaatggccag taggcacatc attaccccta agggaaatca aaatcacaat gagttaccac 65760
tttgcatccc ctaagatggc tataatataa aaattaacaa gtgtttgtga ggctgtggag 65820
agattagaac cctcattcac tcctcctagg gatgtaaaat agtgtctgag ctagggaaat 65880
agtttggcag tttcccaaaa tgttaaacat agggttacca tatgactcag tgattaagct 65940
cctaggtata tactcaagaa aatcaaaaca tatgtccatg taaaaacttg tacatgaata 66000
ttgatagcag cattgtttat aatatcccta aaaggaaaca acccaaacat gtatcaacta 66060
ttgaatggat aagtgaaatg tgttatatcc atacagtgaa atattattca gcaattaaag 66120
tgacacactg actcatgcta ggacatggat gaaacttgaa aacatgatgt taggtgaaag 66180
aagctagtcg caaaagatca catttgattc catttatatg aaatgaccaa aatagacaaa 66240
tctataggga cagaaaggag attcgtggtt atatgtggct ggggaaatgc aaattaaaac 66300
tactaggaga tacataccga tggtatgtat gcttatcttt aaattatctt taaatttttt 66360
aagataataa gataaagatg tgaaactatg aaactctcat ttactcactg ggagggtata 66420
aactggtaca accacattag aaaagaaatt ggcgtatctt ttaagattaa caacacatat 66480
accttgagag ccagcaaatc catttctaaa ttctactcag tagaactatg tgcatattta 66540
tatcaatagg tgtacaaaaa tattcatagc agcattattg taatcaccca aatgttcatc 66600
agaagtataa ggaataaata aattgtggta tattcctgca atgggatatt atatagcagc 66660
tacagttaca cccagcaaca tgtataaatc tcacaaacaa catcaaataa aaaagccaac 66720
cacaaagtag catccactat gattcccatt tatgaagttt aaaaacaggc ataactcaac 66780
tatagtatta aaagtcaata tagtagttca ccttaaggga gaagggaaag agtaaaaagt 66840
ataatatgag gtagaatttt gaggtattgt aatgttctct ttcttgggtt atagttttct 66900
atatgatgtt ttctttgtta caatttactg agctatacat ttttaatttg tacacttaaa 66960
aatacatttc ctggccaggc gtggtggctc gtgcctgtaa tcccagcact ttgggaggct 67020
gaggcaggca gatcaggaga ttgagaccat cctggctaac acagtgaaac cctgtctcta 67080
ctaaaaatac acaacaaaaa ttagccaggc gtggtggcgg gcacctgtag tcccagctac 67140
tcaggaggct gaggcaggag aatggcgtga acctaggagg cggagcttgc agtgagccga 67200
gattgcacca ctgcacttca gcctgggtga cagagcaaga ttctttcaaa aaaaaaatat 67260
atatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtatgtgt gtgtgtgtgt gtctgtgtgt 67320
gtgtgtgtgt attctggccc aagattatag ttttttttaa ggcagtctgt caggggtcta 67380
caattgtatg agttataaat aaggagtgac aatatcttca gtgaactcct gaacatgaaa 67440
accaagggtc gactgcgaat accttcttta catacaacca gacattatgg aatgaatgtg 67500
ttccccccaa attcatatgt tgaagctcta actcccagtg tgtctgtatt tggagatagg 67560
gtctttgggg aagtaattaa agttaaatta ggtcatacaa cctacagaat tggagaaaat 67620
atttgcaaac tgtgcatctg acaatggtct aatacccagc atctataaga aacttaaatt 67680
tacaagaaaa aactaacaac cctatgaaaa agtgggcaga gttaattttt tcatgagcaa 67740
tggaaaaaaa ttaaaaagtc tgaaagcagg caaagaacat gaacagacac ttttcaaaag 67800
aagacataca tgcagccaac aggcatatga aaaaaagctt agtatcactg atcattagag 67860
aaatgcaaat caaaaccaca atgagatacc atctcacacc aattggaatg gctactatta 67920
aaaagtcaaa aaataacatg ctggcaagat cgcagagaaa aatgaacaca tacactgttg 67980
gtaggagagt aaattagttc aacattgtgg aaagcagtgt ggcgactcct caaagagcta 68040
aaaacagaac taccattcac cagcaattcc atttgtggtt gtatacccaa aggagtataa 68100
atcattctac cataaagacg caggcacatg aatgttcatt gcagcactat tcacaatagt 68160
aaaggcatgg aatcaaccta aatgcccatc aatggcagat tggataaaga aaatgtggta 68220
catatacacc atggaatact atgcagccat aaaaaagaat gagatgatgt cttttgtttg 68280
aacatggata gagctagagg ccattatcct tagcaaacca acacaggaac agaaaaccaa 68340
atactgcatg ttctcactta taagtaggaa ctaaatgatg agaacacatg gacacaaaga 68400
gaggaaaaac acacactaca cactacctga gggtggaaga tgggaggagg gagataatta 68460
gaaaaaataa ctgttaagtc ctaggcttag aacctgggtg acaaagtatt ctgaacaaca 68520
aaccccccga cacgagttta cctgtataac aaacctgcac atgtacccat gaacttcaaa 68580
taaaagtctg tgtgtttttt aaggcagaag tcagccccta ccttgaaaga actttctaca 68640
tagatggcta cagtgttact gagcgttttt tttttggtct atcctgaatg tcatgggaaa 68700
acttttaaac tgctctggat caagattagt gcctgtggta tttcatttct cctactcaac 68760
tgttgcagtt acatgatctt agaaattctt tttggcatat tgatgactgt tatcattcaa 68820
gttacatcaa gagagacttc tttctatgag gagctattaa gaccctcttt tggacacata 68880
cacaacttca atttacatct aagacaactt attttaatga aattgcttat ttgtttgctt 68940
tagtccttag attatatgat catttgggca gggactattc tttgaatatt tcctggcaca 69000
tttttgtctc aataaagagg aaggtgaagg aagaaagaaa ggaaaggaag aagggaggga 69060
ggaaggcatt cttgttttct atatcctaaa cctataattt tgtcaaaaaa gaatattaaa 69120
tttgcctaaa atgttaacaa aaaataggtc ataatgatgg ggccctaatt caacagggct 69180
ggtgtcccta taagaggaag aggcattgaa gtttgctctc cctgcatgca caaagagact 69240
atgtgaggac acagcaaaag gacagctgtc tacaaaccag gaagaggcct cgccagaaat 69300
cagcccttga aaaaacctgg gtcttggact ttttgcctcc acaactgtga gaaaataaat 69360
ttctgttgtt taagccaccc agcctgtggt gttttgttat ggcagcccga gcagactgat 69420
acaccagaca ttcactgtat ccaactgttt caccataata gcctttctta ttttgatcaa 69480
attactgcat caggatttga tcttaaattt catgtttcct ttgcttttgt aaatgtagct 69540
gagcatccaa atttcactca gtttggatgc taacaagatt agacagttat ctgacagtaa 69600
tcagtgcctg atcctattct gtgtcttctt ccatcaccat cccactaaag agcttgcatt 69660
ttttgtttct tttagccaga tagtaaacat ttttcaggca ttttgaattt tgccattgta 69720
aatggtgaaa gattctctct ctctctctct ctctctctct ctctctctgt gtgtgtgtgt 69780
gtgtgtgtgt gtgtgtgtgt attaggaggg ggtggtgatc gggatgctaa tctatgcaca 69840
gtgacctttg tttctatctg gctgagcaga tgtaggaatt aatcattgtc actcctggat 69900
ggtgctgctg cagctgtccc ccactgcctt tctgcccctg atagatttat tagtgtgttt 69960
tgtttgctga aaagcatgcc tcagcacaga agaactggca aattagagaa gctttatctg 70020
tgagtataat tttttggaaa catggttttt tctacacatc tgtacctata tactctgagc 70080
tctttaaaaa aaaggaggag gaagagagca aagaaagaaa aggaaaacaa acaggtaata 70140
ttgtttctgt aacatcagaa cgattatttc ccagctgaga atgttcatac tggaacagtg 70200
tcatggccat ccaccttagg attgcagaga accaattgtt ttctaacctc tgtatttctt 70260
tttgcaactg cccaccccct cacccactta actgccaact atcagccaga attttggcat 70320
actttggctc taggcacaag aaaataagtg gtctgggtta cttagtgcta aatttatttt 70380
atagtaggcg tcactacaac cttgagactg taactaacac tttctaggct ccaagcaacc 70440
ccactacgta gatatccctg cagcctcatc aaattcaacc cgtggggata ttgataccgt 70500
cctggatgga aatcagagta gccacacccc tttcaatgtt gggaatctgc caaacaattc 70560
agtataaatt tcctgggcct gggctgtgta ttttcattcc accccacccc caaatcagtc 70620
agcatgccct ggggcagaga ctaaagagcc gccagtgcct attcagagtt ggcttattcc 70680
tttctgatgg cccatcccct ccccgaaatc caagaccttg gccttagata tcttggctag 70740
cctgggcctt tctggtacca cccttcactc tctaggagct ctgagaattt tctgcacttc 70800
ccgacgctgc ttgatagagt gactcacagc ttactctttc attgactctt tctgtatttc 70860
tcttcttcag aatttctctt ctgctgctgc ttttagacat ccttgcatgt tcagtcccta 70920
aatcaccact gcttgttatt actttcatgt tcccaacatc tggcatatgg gtcttaatcc 70980
catgggtcca cccagactca tgaatttaaa ctcttctggt ctaaactctt ccaccaccat 71040
ttgagcctca attctgtgaa cagttttgtc tctaaaagcc acatacctta gtgtaagaag 71100
gcagattaat cctctgaatg tcaacttaac agttaggcct atctcccaag aaagagaaat 71160
gaaaactcct aattagtaat gactcatttt gatcaaataa tcaatttttg gaccattttc 71220
ttaaaactat attttattgc ctgtaactat ttcctggagg ataataatca tccttaaatt 71280
actatgtgtt ttgtgaagtt ggtgctttac ttttcgtgtc ctaaatatgc atatctgaat 71340
ctttaaattg tagcttctct ttcaagtgtt ctaggatttc atttgccatg gttgggatct 71400
ctttgtgatt tgataggttt cgatcacatc ctcactagcc ttctttccaa gccacagaac 71460
ggtctgtctt cattcagtag agaccctgcc attctagttt tctcgctgga atttgttttc 71520
ccatatcctt cttgagcaaa ggtgactaaa gccaaatgtt tcattctggc actttgtgag 71580
acgtgggctt taagctctca aaagaagaga aaatctcata gttttatatg agatatacaa 71640
tgaacaatag taaaatagaa atgttattgg caagaggagt ttttctccaa tatccatgag 71700
taagaattcc ttggacacat aagataacaa gaggaatata cttactctgt tttccttttg 71760
agatattctt tacataccat gaagttttcc tttctaaagt ttgcaattta atagttttta 71820
gtatattcac aagcttgggt aaccaccatc actatctaat tccagaacat ttttatcacc 71880
tgcaaacaaa accttgtacc tgttagcagt ctctcctcat ttctctcttc ctcccacacc 71940
tggaaaccac tagtctactt tctatctcta tagatttgcc tattctggac atttcatata 72000
aatggaatta ttgaacatgg ggccctttgt gtctggcttt tctcatttag cataatctta 72060
gcataatatt tataaggttt ccctgtgttg tagcataaag cgttacttca ttccttttca 72120
tggctgaaca tcccattata tggatattcc acattttgtt tatccattca tcagttgatg 72180
ctatctgttg tttccacttt gaggctctta agaataatat gctgctgtga acatttgtgt 72240
acaagttttt tcatgaacat gtttttactt atctgggtat atacctagga gtggagttcc 72300
tgggttatat ggtgactgtt taacataagt gtagaactgt ttttcaaagt gactatacta 72360
tttcacaatc ccaccaacaa tgtatgaggg ttccagtttc cctacatcat cactaacact 72420
tgttttatta tctgcctttt taattctagc catcctagtg ggtatctcat tgtggttttg 72480
agtcgtattt cccttatgac caatgatgct gagtgtcttt ttatgtactt attatccatt 72540
tgcttatctt ccctggagaa ctgtctattc aaatcctttg acatttaaaa aaattagatt 72600
gtcttggggc cgggtgcggt ggctcatgcc tgtaatccca gcactttggg aggctaaggc 72660
aggcagatca cctgaggtca ggagtttgag accagcctgg ccacatgctg aaaccccatc 72720
tctactaaaa atacaaaaat tagctgggta ttggtggcac atgcctgtaa tcccagctac 72780
tctggaggct gaggcaggag aatcacttga acccaggaga cggaggtttc agtcagccga 72840
gattgtgcca ctgcactcca gcctgggcga cagagtgagg ctctgtctca gaaaaataat 72900
aaataaataa ataaataaat attgtcttgg aaatatactt aaattaattg gcctatagtc 72960
ccagctactc aggaggctga ggtgggagga ttgcctgagc ccaggagttt gatgtttcag 73020
tgagctatga ttatgtcact gctctccagc ctgggtgaca gagtgagccc ccatctctga 73080
aaaaaaaaag gaagaaagag gaagaggaag aagaggagga ggagaaggag aagaagaaat 73140
gctcttaagt caatagttct caaacttggt tcacattaaa gtttcctaaa atcctgatgc 73200
tcaggcttta ccctaggcca gttaaatgat aatatcttgg ggtaggaccc aggcaacagt 73260
tttagaaaca aatctccagt tgattctaat gtttgagagc cattgctata gactacatga 73320
ctaagctgat gataccaata taaaaatgtt aaagatttga taatttagaa attatgccag 73380
gtattaaaaa tgggagactt aactcaaatg tgaatcataa aatgcctaat caggtcaaaa 73440
gatagagttg agatttgtaa taaagattga taaactttcc tataatagga agtttcaaac 73500
cacctatagc tagagaaaat gtctggctgt ggttcttgcc tagtgagcag gaattggttt 73560
tatgaggtaa ccatgggaga gccaataaat gtgagtgatc atgacaatta aatctttaag 73620
cccagataat ttatgtcaat tattcaatgt tcattaagga aagtgaaaaa aaatgagtat 73680
tagctaggag aaatggaaag ggaggctttt gaaaggcata aaaagattgg aggctatttt 73740
aagagacttt attggaagca tagaaaaaga gtatctgaga atttttaaaa atccaatcac 73800
ataaaaatgt gacagtcaca gtggttattg tggagggaaa atgacatctc tcaaagaatg 73860
taaaaagctc cccaagggag agcagggagc ccacagagtg tattaggtta agtacaaaat 73920
aggaaaaaag actttaagaa acactttcga agagagtcca aaacacataa agggattatt 73980
taaaatctat taaaaggaag aagctagaat aacagtggga tcttttgctg agaataaggg 74040
ggcacaggga gtgctgaggc accaaaagac aatagacaaa ctaattatgt gcctctgaat 74100
gtattgagaa agataccaga gtgatagcac attcaaattg cctactacga atggatcagt 74160
agtagttaat tcaatggttt tctgtgtttt gcatatttca agtcaggtag gcagaataaa 74220
tactgattaa tcactggaaa ctcttggtgt ttatcttgag atttctgaag gcctccagaa 74280
gaaatttttc tcgtcttgcc tctccctaaa gccactgccc ttgtcctccc tctcctatta 74340
ccaccaaggc tcctaagtgt atagtctacc ctagtcacct cactttctca tctccaattc 74400
attcttcaac ccattcttct aactccattg aaaggtcatt aaatctgact cattgccaaa 74460
gtcattaaat caacagatcg ctttttagac taaattcttt ctagccttta gatatataac 74520
accattaact gtttcttctg ttcttccttt ctgaaacctc ttttcttaac atttattata 74580
tgtgaatgtc ctggttttac ctgtctactt cttgctagct accttcactg gctccagaat 74640
tacttacgta tttctctttt ttgttttttt tttttaaggc tagtcaagtg aagcagtggg 74700
aatggagaag gaacacagaa atctgtaact ggttgtgatc aattaattgt agacactact 74760
gacttcagac aagccttacc tatttaattt tggtaacact ctgggttcca gtctcgattc 74820
acttcttaca ctatatcctt caccttgttt taacctctcc tgtgacatat cctagtgctg 74880
cctctcttcc cattttctaa cttcatggtt gatatagtca tatagatgtt tcacagttta 74940
ttctgatcca gtaaccaaaa ccagattaat atcttaccag caaacttgct cttcctttgt 75000
gtaattcctg tcgtggttaa tagcactacc atccacccgt tctcattctg gattcctttg 75060
tctccctaca catccggcta gttaccaggt tttagatatt taacctctga aatgtctttc 75120
aaatctttct attgtccatc tccattgccc aaccatagtc ttcatttgtt tttcatctgg 75180
actattgcaa tagtccccta actcatcttg ccgacatttt cagctactga tctcttgcca 75240
gcattttttt ttccccaaac acaatctagt tttaaaatac agacttctac tgcctacata 75300
actccttagg taagtattta aggtcttttg tagtctggcc ctaacataaa atatccactt 75360
ttccccttga aattaagttg tgccctggtc gtacatgaga atggccattc cttgagcaca 75420
ccatgcacat tcctcaccat gtctttgttc atgctcttcc ttgtttcaca actcttctca 75480
tttatcacct gacaaactcc tatctatcct ttaagacaaa tttctgtctc tcaaaatgtg 75540
ggccctgggc cagagcagca gtatcacctg ggaacttgtt agaatacaac ttcttggggc 75600
cccactttag actctgttta atccaaaact ttgtgtgata aggaccagca atgtgaattt 75660
taacaagctc accacatgat tctgatgcat tctaaaattt aagaaccact gttctaggga 75720
acaatttttt tatcaatggc catagcactt tacacatacc tgtattactt actgcattat 75780
ttaataacca tgtttactta ttcacttatt tatctggtct gctaagttgt gagtccccag 75840
agtcaaatac aatggtgctg tgttctgaca cctgccatag tgtctagcac ataacaagtg 75900
cttgataaga attcagcata ctaaaatata cccccttccc tccaggattc agtctagcta 75960
gagtaaatag agagggcaag atcaaatggt gtccaaggca tctactctta aaggtcgata 76020
tacaccacac aaaccaaaag cttacacact gacaataaca aatgtcagca aagtaataac 76080
caacgggtac taggcttaat acctgggtga taaaataatc tgtacagcaa actccaatga 76140
tactaattta cctatgtaac aaatatacac ttgtacccct gagcttaaaa taaaagtttt 76200
taaaaaaata aataaagcaa atgtcagcaa ggatgcagag aagctgaatc tctcatacat 76260
tgctgatgta cctactctgg aagacacttt agaagtttct tataaaatta ttccctcact 76320
gtgcgattca gcagtttcac tcctgtgtat ttaccgtaga gaagtaacta tgtatgttca 76380
cacaaaaagc tgtatgcaaa tgttttttag cagctttgtt tgtaatagtc aaaaactgga 76440
aacattaaca atcaaaaaag aaatcaagaa aacaattcca tttgtaatcg catcaaaaaa 76500
tgaaaacttg ggaaaaaatt ttacctaaaa gatgaaagac ctatacactg aaaactataa 76560
aacactgatg aaataaatga ggaaggcaca aatcaatgga aagatatccc atattcatgg 76620
attgaaaaaa tttatattgt taaaatagcc atactaccaa agcaatctac aaatgcaatg 76680
caatcttacc aaaattctga tggtgttttt cacagaaata tgaaaaaaac taaaattctt 76740
atggaaccac aaaagacccc aaatagccaa aacaatcttc accaataaga acaaagctgg 76800
aggtatcacc ctagcctatt taatttcaaa atctactata aagctatagt aatcaaaaca 76860
gcatgatgct ggcataaaaa cagacaaacc aatggaacag aatagagagc ccaaaaataa 76920
atccatccac ttacagtcag ttgatttttg acaaaagtac caagaaaaca caaaagagaa 76980
aggacagcct cttcaataaa tggtgttggg acaactatgt atccacatgc aaaagaatga 77040
aattatgcct gttaccccag cactttggaa ggccaaggtg ggccgatcac ttgaggtcaa 77100
gagtggagac cagcctggcc aacatggtga aaccctgtct ctattaaaaa tacaaaaatt 77160
agccaggtat ggtggcatgc acctgtaatc ccagctactt gggaggctga ggcaggagaa 77220
tcatttggac ccaggaggca gaggttgcag tgagctgaga tcgcaccact gcactccagc 77280
ctgggcaaca gagagagacc ctgtcttaaa aaaaaaaaaa aaaaaagaaa ttggacattg 77340
gacccttata ccatatacaa aaaatccact caaaaatgaa ttaaaagctt aaatgtatga 77400
cctgatactg taaaaactat cagaataaaa cacaggagaa aagctcctgc cattggtccg 77460
ggcaatgatt ttttggttat ggccccaaaa gcacaggcaa caaaacaaaa catagacaaa 77520
tgggattaaa ctaaaaagtt tttgcacagc aatggaaaca ataaacagag tgaagagaca 77580
acctacagaa tgggagaaaa tatttgcaaa ccatacatct ggtaaggggt aaatattcaa 77640
agactataag gaactcaaat caatagcaag aaaacaaata atccaataaa aagtggacaa 77700
aggacctgaa tagacacttc tcaaaagaaa acatacaaat gtccagcagg tatatgaaaa 77760
aattctcaca tcactgatca tcaagaaatg caaattaaaa ccatgagtta ttagctcata 77820
cctgttagaa tggctcttat gaaaaagaga gatagcaaga gttggggagg atttggagaa 77880
aagggaaccc tatacactat ttgtgaggat gtaaattagt acaactatta tggaaaacgg 77940
tatggaggtt cctcaaaaaa ttaaaaatag aactatcata taatcaagca attctacttc 78000
tgggtgtgta tctaaaggaa atgaaatcag tgtatgaaag agatacctgc actcccatgt 78060
tcactgcaac attattccca atagccaaga tatggaacca acctaagtgt tcatttacta 78120
atgaatggat aaagaaaatg tgagatatat atgtacacat acacacacac gatggagtac 78180
tatttagtct taaagaagga aatcctggca tttgcaaaaa catggatgaa cctggaagac 78240
attatgctaa gtgaaataag caagacatag aaaaacaaat actacatgat ctcacttaca 78300
tgtggaatct aaaaaagttg aactcataga agcagagagt agaatggtag ttgccacaga 78360
ctagggtgga ggtggttgac agaaatggag agatgttggt cagatcaaag agcacaaagt 78420
tccaggtagg acagataagt tgtggagagc tatacagtat agtgtctata attagtaata 78480
acgtgttgta tacttgaaga attccaagag agtatgtctt aaatgttctc accataaaaa 78540
aagataagta tgtgcagtga tggatgttga ttaaattgat ttaataattt taattatttc 78600
acaatatata caaatatcaa aataccatgt tgtataccat aaatatataa tatttgtcaa 78660
ttctgcctta ataaagctgg gagaaaaaaa ctggaaaccc aaatatcctt caacaggtga 78720
atggataaac tgtgggacat ccatacaatg gaatactatc tagcaataaa catgggacaa 78780
agtattgata gatgcaacaa cttggatgga gctcaagggc atatgctgcg tgacagatgt 78840
cagtctcaca agcttacaca ctgtaagagt ccagttctat acaacattct taaaagacaa 78900
atttatagtg atggagaatg ggttagtggt tcctaggagt taggttgggg aagcgtgtca 78960
ctataaagga tagcatgaga gagttgtgtt tataagtgtg tatgtgtgat ggaacagttc 79020
actatcctga ttatgatggt ggtttcgtgt ggtgaatttc atagaaatct atatatgtga 79080
taaatttcat aggactacac acacacacac acaaagtgca cataaaaact ggtgaaattt 79140
aaatagagcc tgtagtttat ataatagtat tgcactaatg tcaatttcct gattttgatc 79200
atgaactctg gttatgtacg atgttattgg ggaaagctgg gcgaaggata cacaggaact 79260
ctctgtactg tttttgcaac ctcttgtgag tcttaaataa tttcaaaatg aaaagctttt 79320
gagaaaaata aagcacaggg atttctgaca aaagctaaat tagaaagcac tgcttgacat 79380
aatgctaaaa caggacccag gaagtggaga gctcactgcc tggtggaggt gggaaagggg 79440
taaagggaag tggagattct tgccttgaag aacatttggt agaacgtggg ccaggcctct 79500
caaacaggtc actcctggct tggggaggag ctaatactaa ggtggaaagg gaaatgaaag 79560
cttacttctc atcagcttcc catatgggga agggggccgg aatctctcct caataggcct 79620
ccattttctc aatagggaaa acggagagaa ggggaaaagg gttcctcttt aacaatggtc 79680
acaaaaggtg atgtgtgcag tgaaagatta aatggtataa gaactcaggc tctggaatca 79740
aacccagcct caaatccagt ggcttgattt tctattgaac tttgctatac cctgtttctc 79800
tatttaaaaa caggggtaat gatactactt aactctgaaa gctgattaca ttagattgtc 79860
tatgtagagc acttagcaac cacctagcac atagataatc agtgttggct actcttttta 79920
atactattct atgccattac caattttcta agacgtaaca ataatacact cagatgattc 79980
tgaccataat gtaatttttg attaaagttt cttcaggatc cttcaatgct tccaactcat 80040
aaattatatc agccctcagt ccctatatat gtaaatacaa tttaaattaa aatagttgtt 80100
actttctatt acatgtcttt tatgtgcttt gcactttaaa tacactattt ctaaccttta 80160
tagcatgcag gataaatact attttcccca ttttcagatg aggaaactgc ttcagagtgg 80220
ttaggcaaat ctccaacatc tataaacaac acagtaaacc taggcagtct gatggcaaag 80280
cccaagctct ttccactaca ctgttacctc agtagtaatc cataaaagat gcttaaacac 80340
atacatattg tctattagtt gttcttttta catcacatta catgggcaga ctctacaact 80400
cctgccacag cctggcgcag acacttccag gccattgctg aagccagtgg agacaccaga 80460
cgatgacaga aaccaagaac ccaaagctga ttgtagcaag aattcagtct ggagttcagt 80520
cagtagataa atccgagagg catcatggaa attgtgccaa ggtccaaggt tcaagccagc 80580
agtcagaatc taaaggggca ggcaaaaccc agcaggaggc tctgcaggct ctgtgccccc 80640
cgggagattc atggcttcct ctctgtctcc tcttgttgac actgccggct ataaatgggg 80700
gctttgtgga tcctcagttg aggaggcagg tgaaaattct tggcctacca gcactactac 80760
aggacgttag aaactagggc aggaagaccc tgggtcttca ttaatcagtg tgatgaaaac 80820
aggccccagg cagttgggtc cactagtggg aagtgaaaga acactgaagg aaaccaggag 80880
tcaggacatc tggatttgct gtcccaacat ggtccctatc tggcgataaa acagcatgca 80940
aatttcttca tctaaaaatg aaggaatcag gtcagatcac tgattttcaa actgtgttcc 81000
tcagaaccca aggactccag tcctgctgtg gagagatagg tgggagcaag caaggccttc 81060
ctgtacagca cgcttccttt catctcttcc aagtactgaa ccttctaatt ctaatgattt 81120
attcagcgta acaggcattt aataagtttc tactaggctc ggggccttgt agaaggtgct 81180
gatggggaca aagctgagta aaacccagtc ccaacatcat gaattcctag attctggctt 81240
aatggggaac cattccagca gctgtcactg ttcaggattc ctctcagatt ccaagataca 81300
ccaaggcccg gagttctgcc acagaattga agataagaaa gagaggaaag aggccgagtg 81360
cagtggctca tgcctgtaat ctcaccactt tcggaggccg aggcaggcgg atcacctggg 81420
gtcaggagtt tgagaccagc ctgaccaaca tggagaaacc ctatctctac taaaaataca 81480
aaataaattg ggcatagtgg tgcacacctg taatctcagc tactcgggag actgaggcag 81540
gagaatcgct tgaacctggg aggtggaggt tgcggcgagc cgagatcgcg ccaccgcact 81600
ccagcctggg caacaagagc gaaactccgt ctcaaaaaaa aaagaggaaa gaggaatctt 81660
ccccagtatg gcaggcaatc tttcctgcct caaggagatc aatttacatg tcacctggaa 81720
gcccataata ttctgcttta gcagtgactc cttgtgattg gatgtttcct atggccaatt 81780
gtgcctgtgc ttcatgccct acttaaaatc aggacatctg ctctgccctt ttggaagagc 81840
tacaagtctc ctgccaggaa ttgctcaagg ccttttcctg cagctaaacg gagaaaggaa 81900
gttgaaatca ttgcctcata aattacaaca catgccaggg ttgtaaccta gagtctgagg 81960
ttctaggcga aaagaggatt ttgtgtgtgt gtctagtgtt ttccccacag catttaaaag 82020
ctcatctaaa atatattata attgcatgag atatggcaaa aatacattca gaaactaatt 82080
ttttgaagat aaacaaacaa agcagaatgt gcccataata ttcctaagta aagccacaca 82140
aacttccttt ccagtaaggg tatcctttgg ggctttttcc ccctccttgt caccaactta 82200
tcttgaattt atcactatgc tttttcacta ttgttcctaa acttcagctg ttatataatg 82260
agatagtggg catttagtct tatatccaaa tttccatatt tcagctttta aaatagttgc 82320
aaggatgctt ttaaagttga tcctggccag gagaggtggc tcactcctgt aatcccaact 82380
ctttgggagg ccaagatggg aggattgctt gagtccagga gtttgagacc agcctgggta 82440
acaatgagac cttgtctctg caaaaaaata aaaattaact gggtgtgatg gcatgcactt 82500
gtagtgccag ctacttggga agctgaggtg ggaggattgc ttgagcccag tagataaatg 82560
ttgcagtaag ccaagatcat gccagtacac tccagcctag attagagagt gaaactctgt 82620
ctcagaaatt aaattaaatt aaattaaaaa gttgatccta gcaaactaac accggaacag 82680
aaaacccaac accgcatgtt ctcactcata agtgggagtt gaacaatgag aacacatggt 82740
cacagagagg ggaacatcgc acaccgaggc ctgttggggg ttgggggcaa ggggagggag 82800
agcattagga caaatactta atgcatgtgg ggcttaaaac ctagatgatg ggttgatagg 82860
tgcagcaaac caccatggca catgtataac tatgtaacaa acctgcacat tctgcctatg 82920
tatcccagaa cttaaagtaa aataaaaaaa gaaagaaaaa aaaagttgat ccttaggcct 82980
gtttatagtc caagggagct gtgaatgctg aaatttgtac actgtcaatt tatatgtata 83040
ttcacatatt aatatctata gtacacatag attcaggaat gtagactttt gtcaaatggc 83100
ctagtagata ctgataaaac aacttctaat attaaattaa aattttattc tattttaaag 83160
aaaaagaaca aataagaaaa tcgtctttgc aatgaaaagg tcagaaacca aggatgtggt 83220
gtcctaatat gctgatagca gagattatat ctcctttgcc ttcctatcac tggttcttaa 83280
taccttggca agttagtatt taggaattgt tgaattaatg tttggcacat gaagatcatt 83340
aaagcaataa ctcataaagc atggggaaaa caaggtcatt tgctaaaggg gaatttgggg 83400
gcacgatatt tagcaagtct tctttcacac ttatagctaa atattttgtt tatttgatta 83460
tttgattgat ttgggtgtaa attctattgc acctctggta aaccaagtca gcctgccctt 83520
cctggttaag aaagagagac agaaatgcaa agtgtaacca gcttattaat aagccgagga 83580
tagagaaaag aaatttgtct ctgggctggg agcagtggct catgcctgta atcctagcac 83640
tttgtgaggc cgaggcaggc gggtcacttg agcccaggag tttgagatca gcctgttcaa 83700
catggtgaaa ccccatctct actaaaatta caaatattag gcaaggatgg tggcatgtgc 83760
ctgtaatccc agctacttgg ggtggctgag acacgagaat cgcttgaacc cgggaggtgg 83820
aggttgcagt gagctgagat cgcctcactg cactccagcc tggctgcact ctagcctggg 83880
caacagagtg agactttgtc taaaaaaaaa caaaaaacaa ctgtctctgg cataacttga 83940
gaagggagaa gctagaagag acctttggtt tcatcaggtc caagcactgc taaccattca 84000
gctattctgt gggcagaatg tctttgttct tccaggtgca acttcagcag ctgtgggcct 84060
gaactgacag tgcggggtaa ggatatcact ctctccatgt gaaacaaagc aggactacag 84120
gaaagcaggc tgatttggaa aggccaggcc cacccaggac aagaggcagt gctgagtgtt 84180
tggctcatga caaaacataa tttacaaatt tactggcttc aaggatgtaa aaagttataa 84240
tttactggct tcaagggtgt aaaaaggcct gcttcctagc ctagctgcaa gcagcaactc 84300
agtccatgat cagcagattt tctgaagcct gggggtggga tgcatgttgt taacctctga 84360
tgcagatgtc tgctgagagt ctgtaatctg tgtggtcatg aagatgagat ttcatccatc 84420
aattgcttga caagggctat catcgtatct ctgggcctgc gtggctctca acacacgacg 84480
taagaaacat attggacaaa agcatttcct gggagaattc tccagcaaga attcagccat 84540
tggcaaagaa tctttcaagt ggccctatct cactggagac aagtaaacat atacgcagtg 84600
catatgtgaa tatacactcc ttcaaggtgc tgcactttcc tagaaacaaa aagaatgaga 84660
ggaaaaagct ttacaggcat cctgttagga tgctttctct cgtttatttt taggctcttt 84720
tcagctctgt gctaagaggg gaggcaaagg aagggcttac ccagaatgca aagcttttta 84780
gtgagggttt ggggtgtgca aatttgttaa agtggtgaaa acccagtgtc tatggaagtt 84840
cacagcatcc acagcactca gagcccccca aatatctctg gcccttgtgt tcactaattc 84900
caaggaattc tcagccattc caggggactg tggggatccc cctgaaacca ctacaattac 84960
ccagaatgtg cccctcctaa cacataggca ttgaaccagt tcctaactct cccccaactc 85020
tcacagatct ctagtacttt aagagccata tggcacacat gcttagccct cagccttctg 85080
cctaataggg gagtgctttg ccagggaaaa ataagattag ggaagaggac aaagaaagaa 85140
gaagagaagg agtttccata tccattaatg aattcattca acagatggtt atggaacact 85200
taccattttc caaagaccgt actatggtgt gggttataga ataagaaaca gcctggcttt 85260
tgaggagtag aaactgtccg gtggaactaa cattaaaagg tggtaatata acatgacaat 85320
tgtactgatg cacatagacc ctggggtgtt ttagggacat agaggatggc accaaaccta 85380
gactgagggc atcatccaga cagatacatg ctcttgtttc tgtgagtcct gtgaggtgag 85440
tcactcacaa agaaaatgta aagaaataac tcagaataaa taaaaagata gatggcacag 85500
taagcttggc agattgatgt tggagaacgt cagttttggt ggcaacaatc tgcaaggttg 85560
tctaattttc tcctgcacca ctcggctgcc cggatgcaaa agcagacaat ggattgtggc 85620
tctgatctga gttttattgg gcagatgctg cagaagggct tgtttgaaaa gggaatagga 85680
tgttattgag agaacagttc agatgaccaa ccagggatct gaaattaggt agagacagta 85740
agagagactg ataaactatg aggaagcaaa agaaccaagt gactggaggt ctataggctg 85800
tcaatgtaca aatgtggcag gagtaagcac atgagagggc tggaggatag gatgctcact 85860
catttattcc tcagatgttt attgagtgcc ttcagtgtcc aggtagtgtt ctagttctga 85920
gagtacatca tgcacaatgc tattgggagg agaaaacaat aaataaaatc ataataataa 85980
acaagtaaat tatgtaatat gttaaaaggt aataagtact atggttggat gggggcaggg 86040
gaagagaata gagcagaata agaattcaga attccgagga tagggtataa ttttaaatag 86100
ggttgtcatc atagctctgg ttgagaaggt aacatatgaa cacacaatca ggagagaaag 86160
aggatgagct atgcagatac atgtattgaa atattccagg cagagagaac agccacttca 86220
aagcctcgca gtgtgtgagt gcctggtgtt ttcaaggaaa agcaaggagg ctgtgtggct 86280
ggagtggagt gggcctggag aagatgtaag aaatgaggtc aagaaacaac agggatcgag 86340
tgtgtaggct ttgtagactc tggtaaagac tggctttccc tctgggaaat agagagtcat 86400
tgtggggttt tgagcacaga agtgatgtga tcttatgtct ctttaatgga ttactctagc 86460
tgctatgttg aaaatagact tgagggaagt gccagggtag aagcagggag accagttagg 86520
aggctattgc aataatccaa ataagaaatg caaagtaaga ctttgatcag gtggtggcag 86580
cagaggtggt gagaaggagt tagattctgg atgtatttcg aggatagagc caacaagatt 86640
tatgacagat tggatgtggg tagtgagcaa gagtcaggat gactccaagg tttttggtcc 86700
aggcaaattg aaaggtggag ttgccattat ctgaaatggg gaagaaggtg agcaattgag 86760
agggagactt ggagttaaat tttgaacaga ttgtagtcaa attggtgttg ggatattggt 86820
gtttacaatt cctgaagggg aaccattctg agtgacccta agacccagag tgtaacctgg 86880
ggatgggtgt ctgaagagga ataaagtgaa atcattatga ttgaataatt tagaactctg 86940
gaggctgaaa agctaatgaa atctcctagg atgttctacg aggatggtgg cccaggcacg 87000
agagtaggga acggggtcag gccttatgat ggatacttta aatacaaata gttagaggtc 87060
acactaatat tagcttgagg tgtgcagaat tttaattggg tgcagattag tgtatacatt 87120
agaaataagc aagatattaa aagatcaaat ttgctgaaac acatcagata acattatgat 87180
aaaggtattt ggagttttat ttgagttaga tttacaatcc cattgtagca tggatcaaaa 87240
acagtaagtt gataaagaaa tcagataaat tttcacaatt taaattttaa ttgttttatt 87300
aaaaagcatt ttggaaagac attcatattt ggttttggat aggttaaagc tcagtgatac 87360
catttacatc aatttttata gcattttaga gagcatggtc ttgtgacatc ttaggataag 87420
ttttctgtta gtcacagcat gccaacaagt accttgtgct ccattctctg gccatgtttt 87480
cagactcagt aacttcaaat aaaataaact gccaagttga gaaattaaca tttgataaag 87540
tttttgcaac atcataccat tgagctggtg gatgtggctt aagcatctga attcattaga 87600
gactattgaa atgataatgc agaattatac aggttttgca gatgtagttc aatatttatc 87660
tatatgtatt gaaacctcac ttgaggatag aaaaatcaag caagttcttg tcttacattt 87720
ccactcaata aatgaagagg aagagataat gagaaagcta tataatcctt taaaaaaaaa 87780
attcaccttg tttctgactg acagtaaccc aattcaggct ttttactctt cataaatgga 87840
agacaagtaa cctagatagt actggctatc tataattaaa tatacaatat tgaaatctat 87900
ttgctttgtg gaaattatgt gtttgtggct gattaaaata ttcagctatg taggcttcat 87960
cttttagctc aatagaaaaa tataaatgac attggtgact gaattcctac caacgtggca 88020
aagacattcc ccagacatac ataattcacc tgctgaattg gagatgattc acctttcagt 88080
gacttcacag gtgttaactt ggccaaacaa aaaagggaaa tcatcttgta ttcatctttt 88140
gttccctgag gcaagttttc agtaagattg ctcgggaaaa atatcacaat atacatatat 88200
aagtccatag tatgtctatt tgaataatga attagcacca ctgtctgaga ggtgaaaact 88260
attcaatgta tattttctgg aaaataacta aattgagttc ctcttaacta aatcagaaag 88320
agaaggaatc ctcaatcagg atttcatgta gtactgtatc actcaaagga aaactgattg 88380
tatagtggta ctcaaataaa gtgggtccaa agaaaaatta tgagagaaac gtaccgatca 88440
gtgatctgga ccaaacagac atgtggctgt gaaatccagg cagttgcttg gtgacgaggt 88500
caccatcaga tagtcatggc ttatgtgcag gaatgtgaga atggccatgg ggaggaatgg 88560
cctgggttat gggtcttgca ggagtcccac tgcttgtgcc attgctcaaa cttctgactg 88620
ccctgtgcag ccggtgccag gtcagcagta ctctctgctc tgaatcagtg tcagcactgg 88680
tctctctaat gtagtacctt tcttcaaaaa atgctttgtg aagctgctgg ttagcactgt 88740
tcttacttct gtagttaata ttcaccacat attccccttc ttttgtggag agataaagaa 88800
attaaggaaa atcactctcc ataagtccac aatctgaaga catggaggct gaggaggcag 88860
acctgaatga ataagtggat catatgatag ggctagatct taaatttgga tacaggagac 88920
ttaaggtaaa ccacagaagc ttgttgttta tacatgtagc tcttttgcta aatataaatg 88980
tggcatgtga agattaataa atctgaatgt aatgtacaga atgtactaga acaggaaaaa 89040
attggtgttt actgagagct gaaggttaca tcaaaaatct aaaaagtaat atttttgcat 89100
catcttaaag tttgcaaaca gttttggcac atacatcatc tcatctttgc aataacctgt 89160
ggggtagata caaaagatga tgttattttc attttccaga tgaggaaata ggagcctgtt 89220
tcctggtcag acaggcttag tcagctgtga gtggcagagc tggtgttccc acctgttacc 89280
ctcaacccca gttccattgc tcctaacatg attgtatcct ggataaacat ggtatcaaga 89340
atggagaggc caagcgcggt ggctcacacc ggttatccca acactgtggg aggccgaggt 89400
gggcggatca cctgaggtca ggagttcgag accagcctgg ccaacatggt gaaaccccat 89460
ctctactaaa aatgcaaaaa ttagatgggt gtggtggtgc gtgcctgtaa acccagctac 89520
tggggagact gaggcatgag aatcacttga acctaggagg tggaggttgc agtgagccga 89580
gattgcccca ctgcactcca tcctgcacaa tagaacaaga cactgtctca aaaaaaaaaa 89640
aaaaatggag agtgaaattt gggaggctga ggcaggcaga tcacttgagg tcaggagttt 89700
gagaccagcc tggccatcat ggcaaaagcc tctctctact aaaaatacaa aaatcagcct 89760
ggcgtggtgg tgggcacctg taatcccagc tgctcggggc tgaagcagaa gaattgcttg 89820
aacctaggag gcagaggttg cagtgagcca agatcatacc actacactcc aacctgagca 89880
acagagagag actctgtctc aaaaaaaaaa aaggatggag agtgagagaa aactcagaga 89940
ctttgaaata agaagtgaaa gaggccgggc acagtggctc acacctgtaa tcccagcacc 90000
ttgggagacc gaggcaggca gatcatttga ggtcaggagt gcgagaccag cctggccaac 90060
atggtgaaac ctgtctctac taaaaacaca aaaattagct gggcatggtg gcgggcacct 90120
gtaatcccag ctactcggga ggctgaggca ggagaatcac ttgaaccagg gaggcagagg 90180
ttgtggtgag ccaagatcat gccattgcac ttcagcctgg gtgacagagc aagactctgt 90240
ctcaaaaaaa ttaaaaaaag aagaagaaat gaaagaaact tggcaattga ttgggtgttt 90300
ctgataaaga aacagaagaa ggaaaaggtg attcctaggt ttctaaaacc tggaagaggt 90360
ggacagtgag attataatat aagcagctga tgttggcaac atgcctacta tgtgccaggc 90420
catgtgccaa gcattttgcc atattgcctt attaaatcct tacaactctt tgaaggtaga 90480
tcgcataatt attattctca ttttagaaaa gggtgtgcat gaaagttgct ctcactttta 90540
gaaaaagaaa aaaatcttcc ctccaaaaca aggctaagct caactggatt cactggccta 90600
tgctgacagt acctggggcc tgggacagtg gtttggtgtt cttgtgtgta tggatgtatt 90660
acaatgtcag acacaaagta actaagccgt gctcctggcg gttatgatgc ttgcaaatcc 90720
agcactgcca aactgtttag tgcctcctag gtgctttgcc tgtggttaga acaagcttca 90780
ctaagtggat agttttgcct tggccctgcc tttaaggcag tctgccatgt catcaagaga 90840
cataggtaag aatgctctcc tccttagtta tgatttaaaa ataaaagtat aacaaagtat 90900
aattatcaaa tgactattag tagaaatgtt gcatttatat acactattta gattacaatt 90960
cttaaataca atgtctttcc ttcttgttac ttgtaattaa ttagtatcag tcactgtcca 91020
gtgtgagcct ggcattgccc ttaggttaac cagttcacat cctgaacttc tgttggtgcc 91080
cagggtattt gtctgaaacc ctgattattt acatctccct ctaactttca aatttgtctc 91140
caatctcatc taaaactatt aatacttgag aaaaggcctt tccccaattt cctgcttcta 91200
atccctttat cctctttctt tcttggaaaa gtagaggaaa atggtttaca tatcaaataa 91260
agtaaatagt atatgaaaaa aaaaaaacct ctaagggctc caaactctgt ggatatctac 91320
ctgctggtta tttattcact aagctgcaca tagcaatccc ctagcaacca taaacttcat 91380
gcataaaatc ccaactcttc tccaatacca cctgtttgta ggtagtcatc cttcttttaa 91440
aagacttggg agttatacaa ggaataagtg ccagagttta gttctttgtg aaaataaatt 91500
taaagaaatt ataagttttc acagggctgt aaagatgttt cttcccagtg gtccttcact 91560
ccaaggctgc actggagatt atgctggtga ggaagctttg gtctcgtagg tctttggccc 91620
caaggcaaaa ggtcatggct gtaagtgtct ttcttcctga tcccctctag gattgtgaag 91680
atgtccagtc ccaatctgaa cattgtgacc ttactgggca gttgtctcac ttacagtagc 91740
gcttacctct ttgggattca ggatgtttta gtggggagct caatggaaac tctcattcag 91800
gtaggtgaag ttttaaaatt tggttttgac tataaagttt tgattatttt tttaaaccag 91860
ctgctcccgt gggtggtggt ttcctttatc cttggagtgg gcacttttcg agggaatccc 91920
agaacacttg gtgaggttca ctctgtacct cgtgcgctct gtgggaccca gaccctacag 91980
atcagagtgt gtggagaact gataaaggtt cctcttgtga ctcttctgtc cccttccacc 92040
catagacaag actgtccatg ctgtgcattg ggacctccct tgtgtttggc cccattctgg 92100
gaaagagctg gcgactctac aaggtgttta cccaaagggt cccggacaag agagtggtga 92160
gtaggcagca agtacacaat gcttgactgt agatggtagc ttcagcattg gttaacagct 92220
agagaagctc atgcacatta ctgagcctag cccctttcag gacatccaaa gttcctgttt 92280
ctcattccaa accctggaat catgcagcct cataaggcct caggtctgga aggctgtgga 92340
tcagtgctgt tgaagatagg gcttcaaacg tgggctctgg ttcctatgta ccccaggccc 92400
tgtggggaca tgtgagctgg ccaatacctg gcaccagtgt gaggcagaac aagataccca 92460
gagactgttg tttggcacag gtgcgagctg gaagtgaagg gaggaagagt gattacagag 92520
aaactatagc aagtaagtag ttatttcctt ccctggagtc cagttctttt ctatgtagaa 92580
ggcagttctc tgtactgaga aggatgtgcc caaagcagtg agcaaggaag agcagataga 92640
atcaactcta agttatgtag cagccagatc accgacatgt ccctggtatc agtcatcaac 92700
ttaaccacat ttccccattt tatcaggttg tctgatgaga ctgctcaaac ctcaattcct 92760
gaccattatc ctcattgggt ataggccctg cccagaccca atatatcatt cagttggtgt 92820
ttacttctct ggaatgatgg gaatttattt tagcaaatgt tattgaatca tggtgcatac 92880
ttaccaaaag ctcagctgtg agcaaccata cctatgaaga agattgccta aaaggacaaa 92940
aactgcattc atccctcaag aacaccaatt tcttttttaa acagctttac tgaagtataa 93000
ctgacatgca gtgaactgca catatttaaa gcatatgatt tgataaattg tgacatggat 93060
atacaaccaa gaaacatggt gcataatgaa catatccctc atcttcaaaa gcttccttgc 93120
aaccctttgt tatctccctc ccctgtccaa tccttatatc ccttgttcct atcctcagaa 93180
aatcattgat ttgctgtcac tgtagatgag tttgcatttt ccagagtttt acataaatgg 93240
aaccatgcag tatggactct gttttctctg gcttatttta ctcacataat tgtttttatg 93300
aatattatag ttatttatct atgttgtgtg catcaatagt tatttctttg ttattgctga 93360
gtagtattac aatgcataga cacaatttgc ttatctgtag atggatgttt gggttatcgc 93420
cagttgtggc gattaaaatt aaagctgcta tgaacattcg tgtacaaagt ctttgtttag 93480
acataggctt ttatttctct tgggtgaaaa cctaagagta tggttggatc atatggtaag 93540
tgtatattta actttttaag taacagtcag actgtttttc gaagtggttg taccattctg 93600
catttccacc agcaatgtat gagagtccat ttcctccaca ttcttggcaa catttgattt 93660
gatcagtctt tttcatttta ggcattctaa taggtatgtg tggtagtatc tcattatgct 93720
ttcaaatttg catttctcta atgcagtatt gagcatttct tcacttgctt atttgccatc 93780
catacacctt ctttggcaaa ctttctgttc aaatcttcca cccatttttt ttttttttct 93840
gagacagagt ttcattcttt cgcccaggcc ggagtgcagt ggtgtgatct tggctcactg 93900
caacctctgc cttctgcttt ccagcaattc tcctgcctca gcctcccaag tagctgggat 93960
tacaggcacc caccagcaca cccggctaat ttttgtattt ttagtagaga tggggtttca 94020
tcatgttgac caggctggtc tcgaactcct gacctcgtga tccgcctacc ttggcctccc 94080
aaagtgctgg gattataggc atgagccacc acacccagcc tcactcattt ttaaattgga 94140
ttttttgttg tcttattatt gagttttgtg agttcttttt atattctgga tacaaaccct 94200
ttatcagatg tatgatttgc aaagattttc ttccagtttg ttcttttgtt ccttttactt 94260
tcatttactt cagaatgtct ttcaaagata agacatttct cattctgatg aagttgaatt 94320
taccaatgtg ttctttgttt ttaggtttct tgtttatttg tttgtttgtt tttgtatttt 94380
tagtagagac ggggctttac catgttggcc aggctggtct caaactcctg gcctcaagtg 94440
attcaccagc ctcagcctcc caaagttcca ggattacagg catgagccac cacacccggc 94500
cccaatgtgt tcttttatgg atcatgtttt tggtattata tttaagaaat ttttgcctaa 94560
cttaaggccc caaaaggttt tctcatgtgt ttacttccag aaattttaga gttttagctt 94620
tgacatttag gcctatgatc ggtatatggt atgatgtatt gattgaattt tagtttttta 94680
catatagaca tttgattatt ccaacatcat ttgttgaaaa gattgtcctt tcttcactga 94740
attacctttg tgcctttgtt aaatcagttg tccataagtg tgtagatcta tttctggacc 94800
ctccattctg tctcactgat gtgtctatct caacagcaat gccatattac cctgattact 94860
gtagctttat actaaatctt gaaatcaggt agtattagtt ctttgacttt cttcttctct 94920
ttcaatgctg ttttggctaa tctgggtcct ttgaatgccc atgtgaattt ttgaatcagt 94980
tcactgattt ctacaaaaat tcttttggga ttatgttgaa tctaatagat caaattatgg 95040
agaattggct tcttactaat gttgtgtcct ttgacccatg aacccattta tttaggtctt 95100
taatttttcc catcattttt ttgtactttt caatattgct ctttcacatc tttcatcaaa 95160
cttatttcta gggattttat atttttatgc tattttatat gttactattt ttttaaattt 95220
cactttccag ttgtttgttg ctaataaata gaaatataat tattattatt attttttttt 95280
gagatggagt ctcactctgt cgcttaggct ggagtgcagt ggtgcgatct cggcttaccg 95340
caacctccgc ctcccgggtt caagcaattc tcctacctca gcctcccaag tagctaggat 95400
tacaggtgcc tgctaccaca cctggttagt ttttgtattt ttagtagaga tgaggtttta 95460
ccgttttggc caggttggtc tcaaactccc aacctcagat gatctgcctt ccttggcctc 95520
ccgaagttct gggattacag gcattagcca ccatgcctgg ccacagaaat ataattaatt 95580
tttatatgct tagcttgtat actgcaacct tgctaaacta catgttagtt ctagcagctt 95640
ttttatagag tctatcagat tttctacaaa gatgatcata tcagcagtga ataaagataa 95700
tttatttcca atctcttgtc tgattgcact ggctagatac aatagtacaa tctgaataga 95760
agtggtgaga gcagatatat ttgttattct tgatcctatg gggaaaacag tcaaaactaa 95820
gaatgatatt agcagtagtt ttattgtaaa ttccatttat ccagttgggg cagtactatt 95880
ctattcttat tttgctgaga gttttaatca agaactgatg ttgggttttg tcaaaagctt 95940
tttctgggtc tattgagatg atcatacagt ttttcttttc ttagtttatt cgcatggtgg 96000
attatgttaa atggtttttt ttttaaaccc ttacacaata gactttattt tttagagtag 96060
ttttaagtta acataaaaat tgagcagaag gtacagaggt tttacatata cagtctttcc 96120
ccacacatgc atagcctctc ccattatcaa tattccccat cagagtatat acttattaca 96180
attgatggaa ctacattaat acgtcattat cacccagagt ctgtacttga cattagggtt 96240
cacttttggt gttgtacatt ttatgggtct ggacaaatgt gcaatgacat gtatctacca 96300
ttacagtatc atacagagta gttttactgc cctaaaaatc ctctatgctt ctgctcatta 96360
tctctttctc tccccatatg ttaaatgatt tagggtgtca aaccaacctt ccatccctgg 96420
gattagcttc atttggtcat gctacattat cctcttcata tattgttgga ctcagtttta 96480
taaaaacttt gtttagaatt tgtacattca tgtttttaat acatattgct ctgtggttgc 96540
cttgtaatat atttttctag ttttggtatc agggtaatgt tggctttata aaatgagttg 96600
ggaactattc ccttcttttc aatttcagga ataatttcta tagaatagca taattggcac 96660
tcatgtataa gtaccttaca atagtatgct tccttttatc cccattccta tctttgctgt 96720
tacatgttat aggccccatg caattctttt gtttaataaa tcaattatct ttaaaaatat 96780
tttatttttt tatttttaag acccaggaca acatgctgaa ttttgttatt ttctttaatg 96840
atatttaaat aatgaaaact aatcatgtat ttttctgttt agttaccatt tccagtgttc 96900
ttaatttcct gtatagatcc acatttttat ctcatattat tttcctttgc ctgaaggata 96960
tctaacattc cagtgtgggt gtgctactac tgaattcttt cagcttttga ttatctgaaa 97020
aagtctttat tttgccttca tttctgaaag atatattact gagtatagaa ttctagactg 97080
aaattttctt ttcttcttct agtactttca agatgttcct gcactgtctt ctcacttggc 97140
cttgtatctg atgagaagtg tcaggtttat tttatgtcta cacaaaatgt gtctttcttc 97200
actgcttgct ttgagtagtt tccctttatc actggttttg aacagtttga ttaggcaatt 97260
ggtttgtttt taattttaca aacaccttga atcacgtaac tggttgtgct tcttttcact 97320
ggttgtcaaa agctcagatc cacatttctt ctgctccaat tagtaaatgc tattatatat 97380
acactcttca tctgagcctt catcataatt ccctttattt tctctcttcc cggttgttaa 97440
atattttaat cctatcacag tatatatttt tctcaatttt atttttgtag tcacaaacta 97500
acacattctc ttcatcctaa gtcaaatacg gatggtccct gacataaaac agttcaactt 97560
acagtttttc tattttacaa tggtgtgaaa gcaatccaca ttcagtagaa accatactta 97620
aaatacccat acaaccactc tgtttttcac tttcagcaca gtagtcaata cattttatga 97680
gatattcaac acttcattat aaattaaatt aagctttgtt ttagatgatt ttgcccaggt 97740
gtaggctaat ataagtgttc tgagcacatt aaaggtaggc taggttaagc tgcaatgttt 97800
ggtagcctag gtgtattaaa tgcatttttg acttatgata ttttcaactt atgatgggtt 97860
tatccggaca taaccccatc ataagtcaag atcataagtc aatctgtaat tcatatgtat 97920
ataatgaaaa tgctaatgat tcttcctgca tctctgagtc ccaccctctc agttaatagt 97980
tattaacatt gtggtgtgac attcatatct atgtgcttat ataaacatat agaaataata 98040
gtttatttat tttataaaac accttgagtc ctttgtggga aaaggtagga tatgaagaag 98100
ttaaacaaat ggaaatgtgt aatgctaata atgatatcag catagaagtc attgtaaatg 98160
tttggtgtct gtttcatttt tgatagctac atttgaagct ccttgggagg gctgaccttg 98220
gagcatatag ctgagagcac atgggatact ctagcccctc tgtcatttag ccagtcaaca 98280
aggagaagtt ttgaccttga ctcttttgca gattatcaaa gacctgcagt tgctggggtt 98340
ggtggcagcc ctgttgatgg ctgatgtgat cctgctcatg acgtgggtgc tgactgatcc 98400
catccagtgc ctccagattc tcagtgtcag tatgacggtg aggggccaaa tccctagaga 98460
atctcatccc caaactggac tgacctctgt ggatacacag gagtcatcct tgcaacaaga 98520
agataaagga ctccaagagg agggagagtc aggagttgtg gcttccatgt aattcttgcc 98580
ctagtctgct gccactccca ctgctcctcc tgcccgagtg tctctttgtg ggcatacaat 98640
gagatatcag catgctggaa tctgcctggc agttctgcca cttccacatt atcaataatt 98700
aaaactttca gctatcggca gttaccttcc cctaattgta gaggtggagg tagtagttta 98760
aggtggcctt tggagtcagt caaccctggt tcaaatccca gctctaccaa gctcaccagt 98820
tgtgtgacct tgggaaagtt atgtaacctc tctaagtctg tttcctaatt ggtaaaattg 98880
agataataat actacctatc tcatagggtt gtggcaaaga ttaaatgaaa caatgtaggt 98940
aaaagactta accatgtcca gtacatacta ttcaattaac aagaagtatg gccgggcacg 99000
gtggctcacg cctgtaatcc cagcattttg ggaggctgag gcaggtagct cacttgaggt 99060
gaggagtttg agaccagcct ggccaacatg atgaaaccat gtctctacca aaaatacaaa 99120
aattagccag gcgtggtggc acatgcctgt aatcccagct acttgggaag ctgaggcagg 99180
agaatctctt gaacccagga agcagaggtt gcagtgagct gagattgcac cactgcactc 99240
cagcctgggt gacagagtga gaccctgcca aaaaaaaaaa aaaattatta tatatctcca 99300
gcctcacgag gggctgagga atacagtgga atcatggaat cgtgacactg caagattaat 99360
gtttaaggat tcaatgattt gcaaaaagca ggtgcataat gaaatagttt atagttttgt 99420
tgaggcacta atttgattgg ggtagcaaag cacataaatg aggggtaagc cctagtgtca 99480
ccaagcacac agctgttagc ccaactttat catctcttct cctaacacgt agtcactctc 99540
atttaggttc tagtggagtc acctaaatgc tgcagttttt acatactgag ggggtatcat 99600
gtactctaga agaattcatg ctccagcatg ttcacaaaga tctgctttgt gttcctggta 99660
attgtgggca cctccagttc tgactctgtg tcccttctag gtgacaggga aagacgtgtc 99720
ctgcacttcg accagcaccc acttctgtgc ttcccggtat tccgatgttt ggattgctct 99780
catttgggga tgcaaggttg gtaaccacat ctgatatggt ctctgtcacc aagaaaatgg 99840
atatgaagag ggaattacag gaattaacga ggtgatgtct gcaaagaatc ttgaactcag 99900
aggagacctc tgttgatgca taaacttcaa agccatgact gtttttactt ttctatttgt 99960
atttgtttgg gggagaccct ccaactcttt agactccctc attcagtcct cccccaaatc 100020
atctggaatt cacccactgt ttctcctatt tattggtctg gtttcttaat tgatttgaca 100080
ataccagttt tcccttcatc ttccctgcaa gaggaattat gaggagaaat ttgacccagc 100140
tttatttgtt ctcctaagtg cccttattat gtctcttgtg ttttcttcaa gatttgggcg 100200
aaggtgtcct ggtgcctttc acccacctga ctttctccct ctggttggaa gcaagactgg 100260
ctctgagaca gatggcagca ttcacagggc cctttgaggg gttccacctg tctcacagtg 100320
tctcccatac tgccccaaat ctctcaccat tagactcatt tgtctctgtt agatgggcaa 100380
aagtagaata ttatttccag aaggtagagg atacctgcat ggagcactga ggatggtcct 100440
cagaacagga cagctggttt tcagcttagg gagacagaga actggtgctg aggggtacag 100500
ggcagtcctg attccataaa caagcaagtc ctgcctgaca gcagactacc tgttgactat 100560
cagggcagag agttctggtt gactgattac tggcagagga aaaggaggag tttttgtaga 100620
aataagtacc ctttaagggt aaactctggc cgggcacagt ggctcacacc tgtaatccca 100680
gcactttggg aggctgaggt gggtggatca cttaaggtca ggagttcgag accagcctgg 100740
ccaaacatgg tgaaactctg cctctactaa aaatatagaa attagctggg tgtggtggta 100800
tgcacctata atcccagcta cttgggaggc ttgaggcagg agaatcactt gaacctggga 100860
ggcagaggtt acagtgagcc aagattgcgc cactgcactc catcctgggc aacagagcga 100920
gactctatct caataaaaaa aaaaaggggg ggtaaacttt acccacttca ccactaagaa 100980
agtattagaa gttgttgctt gtgaggaaca ggtttagggg taggccagac tagggcaggg 101040
aaacattcct ttttaactat gtgcaaatat tactttgaca gaaatatttt ttaaaagaag 101100
actctaggaa gtgaacagct cttgatctcc agaatcttgc taatggttaa aaaaggagct 101160
ttagttgtga cagatcaggg tttgaatctg actccgcccc tggctagcca accctgagcc 101220
tcatttaacc tctctgagcc tcagtttcca aattttaaaa tgcggatgat gataatatcc 101280
cctcagaact gttctgtctc taaagagtta atgcatgtta agagttttca gccgctcctg 101340
gtccatagca agagctcaat aaatgttaga tattattatt actattcttc cactgccccc 101400
tagacacttc tggaaaatac attgcctctg ttggttcctt gagtccctgt agaagagtgt 101460
gtcctcccta gcccagaaag ccagcacttc ccccatagct acttactttg tgactcaatt 101520
tgatttattt tctccattgc cttttatata ctctcatttc cattctattt tactgtaata 101580
tctttctgta ggaaaaagaa ggaaaaggat ggagcatcag gaaacttact gagccagacc 101640
ccatagactc cctggtcagt gagaagctcc tcaggaggac cccaatctcc acattgagtc 101700
ctaggacccc tgctctctgt caactgcccc ctaccccaca cttctcagca gttaaggcca 101760
gtgatatgca aggatcaaat atgactcact cagacaccag ccaggaatgt atagacactt 101820
gattcacacc catttcccct ttaacaagaa ttttaatgga attaaaaact tttagtggaa 101880
tcatatctga acatttcaaa atcacagaat taatttcatt tgccttttat taaattagca 101940
atgatccaac tctgctgaat accacctgat ggcgtcagtt acccaaaagt tgggcttccc 102000
tggtctcctg acttatgtgt cctctagtca ttgaagatct cagggtggcc acatttggcc 102060
ttcaggcccc atttgggaca ctgggcatta ggggaacctg gaaggtatct cttccatgct 102120
gactccttcc cttctggcac agccagttct ccaaaatatg ttctttagtg tcacccatga 102180
aggtggagtt gaccacgtca tatgatttga gggtcaccag caggtgtcct gctgatacct 102240
gactttattt tcattattag ttctccctct gaatcccaca gtcccacccc cacctcgtct 102300
cccatggcat cttcacgttc tgagtcatca acatgaacat ttttaggctg ggcgcagtgg 102360
ctcatgccgg taatcccagc actttgggag gctaaggcgg ttggatcacc tgaggtcagg 102420
agtttgagac cagcctgacc aacatggtga aaccccatct ctactaaaaa tacaaaatta 102480
gctcagcatg gtggcacaag cctgtaatcc cagctactcg ggggctgaga caggagaatc 102540
gcttgaaccc gggagacgga ggttgcagtg agcagagatc atgccattgc acttcagcct 102600
gggcaacaag agcgaaactc catctcaaaa aaaaaaaaaa agaagatttt tgtgcttacc 102660
ttaaatctac ctaccagacc aagtgttaaa agccaggacc atgacttctt tgtgtcacta 102720
ttttctgccc tacacgtact atggcactgc acacatagtc agaaaggtga acctaattga 102780
atctatgtgt tatgtattat tgactaaagc tttgatttct gtatgaatgc agctcctgtg 102840
gagggggcag cactttaagg tgctatgagt tattttctcc ttagtacaaa tgacaactct 102900
gagagcaggt ttatattcat aggaaagaga acagaatagg gccctgggtt ccttgtaggg 102960
gagcaagaaa tgtcacaaaa agggtgagaa ctatagatgg agctttcgct gtctgtgcct 103020
gccccacagt cttgcctggg tcccagcctg cctttgttct cccctttttt tacccttcat 103080
ctcccataaa cactcactgg catggagccg ctgctagcct gtagagatcc tttgtgtaaa 103140
ttttttgaag gcccatccct tctagtcaga tgcagtcttg caggtgcaag gcttggcaag 103200
cagatggtgc ctttgggcaa attagagaaa agagcccctt cctatgggca ctaccctggc 103260
tgtggcacat gacttgacaa gcagatcaga ggtcactttc agcttccctg tgcaccctca 103320
gctttgagca gggcaacacc agacaatggc tgtggtagca ctcactatca gaggttctgt 103380
gggcccactg tcctccaagt gcccaacagc tctttctgta gggatactaa cccacccaca 103440
tgatcctgtc ctatgccttg tctcagaaga gtcttattta atggctgact tgctgacttc 103500
tgataaacta attctcagca aaggagagga aaataacatt tattaagtat ctagtaggta 103560
taaggggctg ccctgagggt tttcttatgt gatatcttag taaatcctca tagcagtcct 103620
taaggtaggt attattatcc taattttaca gatgaggaaa ttggttgcaa acctactgct 103680
cattgacctc ttgttccact tctctgagcc tccgtcacct cttcaccccc cagggtctgc 103740
tcctgctgta tggtgcctac ctggctggcc tgactggcca tgtcagctcc cctcctgtga 103800
atcagtcctt aaccatcatg gtgggggtca acctccttgt actggctgct gggctgcttt 103860
ttgtagtcac cagatacttg cattcctggc ccaacctggt ctttggactc acatctggag 103920
ggatctttgt ttgtacaact acaatcaact gcttcatctt cattccccag gtatggattt 103980
tgcagggctg gtcctcttag tcactctaga gtttttcact gacaaattgc tcattttgtt 104040
ttctactgat acctttccat gccacttatt ggagagtcag aaagcagaca ggggatccta 104100
gtgagctggt tgcctttgtc ctttctcact gtcctggtca gcaaggggga caaggcagag 104160
tggtccaagc agtggtggca gcccctgttt gcactcttcc acacctgtgg tgcctgtccc 104220
ttgggggggc tgcctcgcag tcctgctttt ccatccaccc tctggtctgc tgcactcgtt 104280
ccccatcctc ccctcatttc catcatgtta ttactatttc tttcactagc ctgggagcaa 104340
ggaaccttta tatttttcca attggggatt gcagactcac aggaaaaaat ccatttagat 104400
ggaactttat gatttaaagt gctttctctt tctttttatt ggaggaaaat acagaacatt 104460
tctctgcttt ttacaataag gagaggtaga aactaaataa aaatatgttt catattatgg 104520
ggattttaaa aaatcaaatg agggaggaag acagaagcag aaatagccag atagcaaaga 104580
agaaaggtag tcagagggaa cagagaagga atcctaggct cagaaagcaa ggggatgtgg 104640
gattgttcat gctacaccct ggggaccatc aagccacata tatctaggtt aatgaacttg 104700
gcactaggta ctttcttgtt tccctcctag ttctcctttt cttccctctg agacctccct 104760
catcccactc ctccttcaag accctgtcct gattcccatt gcaacttcca gttgactgta 104820
aactaattcc tcatgatgga gctaactgat aatgtaagtg ttggctgatg gcacgttaca 104880
gtgtatttgt gaaagggaag agtgcacttt gggtcatgat ggtatgacat gggcatagcc 104940
ctgttacgat tcttctctat cacaaatcct cattacagta ctcaacagaa tacataaata 105000
tggaaaaatc tgcagcagca gcactagaaa cgatggatgg ctattgcctc tgtgccagaa 105060
actggaggaa tttttgccaa atcttaatgc cgtaaaaact ggaatgaagg aagccattta 105120
gagctgaggc ttgtttgtct gggatgaggc agaaatgggc tctgagaagc aaggactgtt 105180
tctccctggg agaccggggg cgggggcggg gtgggtgggc aggggtaagg gtaggcaggt 105240
gccttttggg aagcccaccc cttaggccct gcagccaata ttgttggatt ggtagcgatc 105300
aacaatgcag agaactggtg ctgaagggta caaggcagtc ctgattccat aaacaagcaa 105360
gccctgcctg acagcagcct acctgttgac tgtcagggcg gagaggcctg gttgactgat 105420
tactggcaga ggaaaaggag gagtttttgt agaaataagt accctttaag ggtaaactct 105480
ggccaggcac agtggctcac acctgtaatc ccagcacttg gtgaggctga ggtaggcgta 105540
tcacttgagg ttaggagttc gagaccagcc tggccaacat ggtgaaactc tgtctctact 105600
aaaaatatga aaattagctg ggcatggtgg tgcacgccta taatcccagc tactcgggag 105660
gctgaggcag gaaaatcact tgaacccggg aggcagaggt tgcagtgagc cgagattgcg 105720
ccactgccct ccagcctggg caacagagct gctaacccct ttcttccttg cttgcctgca 105780
ctatagagac agcaacagct agactcttct tttgccagct tcccatagag ataggagtgc 105840
ctatatgaca ccattttgaa cactagaggt tttctgagaa gcttctgaga aagcttttgc 105900
tttcctgaaa aaggttataa gcatggctaa catcaccctt tttaccttct tcctgccttg 105960
aatgtatgtg attcctagag ctatggcagc tctcttgtga acataaggaa aagactaaga 106020
gaatatagtt ataatactag gaagatacag ctctttccat gtaagattat aaattctgga 106080
ggaaatgatc tatgaaggga atctgcagtt cacaagaaga ggactacaaa tgtctaaaga 106140
tttagagaag ctgccttcct ctggagtaga agtgtttaga agataccgga cttgtcaata 106200
gaattcaaag gatattgtct cttctcaact aaagcaaact atcatgaaaa aaagctaatc 106260
ttaataaaat attgaataag gattaaaaat atggtattaa atttaaaatc ccaatagaag 106320
cattgactgg gcaattagac actacaaaat attgaattag tgaattactt taaggaaaca 106380
gaaaataagg aaacaaatga gagactagat aagaaaatat ggaaaatggc cagatgcagt 106440
acctcatgcc tgtaatccca gcattttggg aggccgatgt gagcggatca cctgaggtca 106500
ggagttcgaa accagcctga ccaacatggt gaaaccccat ctctactaaa aatacaaaaa 106560
ttagctgggc gttgtggcat ccatctgtaa tcccagctac tagggagact gaggcaggag 106620
aatcgcctga acccaggagg cagaggttgc agtgagccaa gatcacgcca ttgcactcca 106680
gcctgggcaa caagagcgaa aatctgtctc aaaaaataaa ataaaaagaa aaaaataaaa 106740
tatggaaaac atctaggaat acaattgaga gctgatagga gtctctgaaa gagaacaaaa 106800
taatttgggg cagaagtcat tatcaaagag ctatcagagg aaaatgtttc tgaacaaaca 106860
aagccttggt cagaaaactg aatgaattgg caatctccat gatggcgccc tgcttactgc 106920
tcctctctcc atcctcacct ctcaccactg cccccttgca tcgtaagcct cagccacatc 106980
acttcccctt tgcctggtgt ttgagtcctc agcagctagg acaattgtga catctgggta 107040
ctctacacac aaaaatgcag aatgaagtgc tgcttgaaat ctgccttcca ggttttcact 107100
aagcaacaaa cacttgattt gttgaattgg gaatggaaat ggaatgatta tgaggtacag 107160
gaattgggtg gatggactgc actggccttg ctttccttct atctcactcc ctctttccct 107220
cctagctttc ttaagcttcc tttctcttac tctgtctttc ctcttccatt ttctcccttg 107280
tgtttttttt ttttctcctc tggaactaac tgaccatgat gtgaaactaa aaaatatatt 107340
ttgtagtctg ttgtatttta ggtttagatg gtaagtagtt ctttttcaaa atataaaaga 107400
aactgaggtt tgttaggttt ctgtgtgttt ccctctggct ccgaggtctt tggtagaaga 107460
acgattctcc ctgtgatact tgcactgtgt attcctagaa gataatttgg gaaagtaatt 107520
tgagtaaatt tgggaaagtg ggtgagggga actatctggg taagggttgg gggttgcagc 107580
aaaacggggt tccttcttgc cagtgagctt tcagacatga ctgtgatggg aggagtttgt 107640
gaaagcaaag gcacagatac ccccagggca gcgaggcagc gccagagagc gggtgaaatg 107700
gatgacatta ctaaggagac aaggggccca agaagccttc tttacacagg cactcaggaa 107760
atgcctgagt gtttatgcca agcactgagg tcatcactag aagtcagcca gccgctgctg 107820
ttctgacctg aatatgaccc atcccccagc cctctgctcc ctcagagagg caggcaggtc 107880
ctaaggtagg acattgtttt ctctctcctc taaccccgaa agcatttcat ctgctcctcc 107940
ctgaagatgt gcaggccttt ctaatctgcc ttataattat atgtatatgt cccagcaccc 108000
ctactagacc agtgagcatt ttaaagaaag cttccttcat ttgttcatgc atgcatccat 108060
ccatccactt attaactgct gggtacatgc acttaaacac agagtccgcc tctaggtcta 108120
gtggggagca aacatgaaag gaattatcat acatgtgtta agagctttga gaaaggcctt 108180
ccccagccca tctgagaact cagtggcacc ttctcagaaa atgaggctgg gcatggtggc 108240
tcatgcttat aatcccagca cttttcaagg ctgaggcggg tagatcgctt gagcccaaga 108300
gttcgagagc aacctggtca acatggtgaa acctggtctc tgcaaaaaat gcaaaaattg 108360
gctagacgtg gtggctcacg cctgtaattc cagcagtttg ggaggacaag gcgggcagat 108420
cacgtgaagt caggagtttg agaccagcct ggccaacatg gtaaaacccc gtctctacta 108480
aaaatacaaa aaattagctg ggtgtggtgg cgggcgcctg taatccagct acttgggagg 108540
ctgaggcagg agagttgctt aaaccgggag acaagggttg cagtgagccg agattgtgcc 108600
attgcactcc agccagagac agagtgagac tgtctcaaaa aatataaagc aaaaattagc 108660
caggcatggt ggtgcatgcc tctggtccca gctacccagg aggctgaagt aggaggatca 108720
cctgagccca ggaggttgag gctgcagtga gctgtgattg tgccactgca ctccagacag 108780
agtaagaccc tgtctcaaaa aaaaaaaaaa agaaggaagg aagggagaga gggagggagg 108840
gaaggaggga ggtaggaagg aaggaaggaa ggaagatgag gtgttcgagc tcagtcttga 108900
aggaaacata agagttcatt gaagagatgg gggaaagtag gtggcatttc tgatggaata 108960
acatcatgac cagaggcagg gaggctagaa agagagtagc gtatgtttgg agcaccatgg 109020
tctttgttat ttttgaagca caaatggaaa ccagggggag aatgacagga ctggggagag 109080
acacacctgg ggagcttctg aggccctgct ggaccctgtt aaagagttga catttagtcc 109140
caccatatta gtttcccact gctgctataa caaattccca caagcttagt ggcttaaaat 109200
aatacaagtt tattatctta aaattttgga ggtcagaaat ctgaaatagg tcttatttgg 109260
ctaaacttaa ggtgtcagga agtctgtatt ccctccagag atgcaagggg agaatctgtt 109320
tccttgtctt tttcagcttc tagaggccgt ctgcattctt gtgcttattg tcccctcctc 109380
caccttctaa gccagccagg ttcaaatctg ccagaagaga ttcaaatctt tctctctctc 109440
gcccctgttt ccattgtcac atctccttct ccaactctgg ctctcctccc tccctcctat 109500
aaggattctt gtgattacat tgggcccact tggataaccc agaataatca cccctcttga 109560
aatccttaat tacatttgca aagtcccttt tgccacataa ggtcacatat tcacaggctc 109620
caggaattag gatgagagag aacatctttg agaagccact gttcagtctg ccacaccccc 109680
atagcccaga ggctcagaaa accagaatct gcctgtcctt ctggaggaag gcagaggaga 109740
ggccctgaat tgtgaaattc atagctggat tccagaaacc ctgaagggtt gagccttaag 109800
gagtatcttc acaaatgagg aatgaagggc tagagtaatc aaggggtatc ttggctccac 109860
ttggccaatt tagagacagg aagaccaaaa gccctgggag ggcccttacg ccagtgctga 109920
gctgctcctc tgccagccct gcagagaggc ctcagtctgg gagtgctggg ggagatgaag 109980
gaaaagctgt actgcagcac tgccagggtc agtgtgagga gaataaccct aggaggtctg 110040
attcatccac ccaaggccac agatgacctt gtgttgttgg ctccagtagc tcccaagtag 110100
gatggtgagc tgagagcatc ctttcgtggg gagggggcct tcaagaaggg catctgagag 110160
gggaggtacc aggcctgacc caacacaggt cacacagact cctggtgcga tgatggactc 110220
atgatgagtc agcagaggac ccaagaggac ttgggtgata atatcaattt cagtggcatt 110280
gaaattgatg gcaggattca gaatcctatc tgagatttac aaaatttggt ttacactcca 110340
tggtcggagc ttaacaaatg tttgatggat gagtaaagaa atcccaggat ccctttgagg 110400
ctacccatag acactgcagc atcatttcta gaatcaaggt cccagggtcc ccagtgtcca 110460
tcactaggac acttagttat ggggattcct gagaggaaaa cagaggcctt ccccactgtg 110520
gcttcctgcg tcactcacat tactgtcatt cggtgggtca gcagtacccc acagactcag 110580
gcagaggctc ctgtttctat gttcagcttc attcctgtta aactaaacca gcccatgctt 110640
ctgcagagtg ttcctcaaga ccagtttctc ctgaagagct ttccctggac tgccaccgtt 110700
aacagtctct ctcttcatca actgagtgag gacacagaca tggcacagtg tcctgcttac 110760
agctgttgtt ctgctgctaa gtggctgtgt aagcttagac acaacactcc tgagcctttc 110820
ctagtttgtc aaagaaactg ggtgatgagc tagagcatcc tgatgtgact agggggcttc 110880
cctcaaaggc tctctgagcc ttgattattg acttgggtta gaagttcacc caaaggaact 110940
gaattttcaa tagcagcaag cacattgtta ctgaacaaat gaaaaataat taaatagctg 111000
catgcaacga gaaagtgtca tttgaaactt atagtgttca ggttgcttaa ccccaggata 111060
gctcctaact ctggctttag aatgtggtgg tagaagatac ttcagctctg gttttctttg 111120
accagtttgg caatgggtag gcagatgggc taaggctgtt ctattttatc tacctgtcct 111180
attcttcctt tggaaatttg tgtttgtttt tagggtgttt tgggtttttg tttttttttt 111240
ttaagattgg gtctcactct gccacccagg ctagagtaca gtatcacaac aatagctcac 111300
agtagcctga aactcttgag ctcaagtgat cctcccactt cagcctcctg agtagctggg 111360
attataggag tgagccattg cacccagccc tttggcattt taaaaattat ataaccttaa 111420
cattttgtat aattacaaaa ggtaaggacc ttttgtcatt accatctttg agccctccag 111480
agcaaagtac attttaagga gagaatagct tgcgcatgtg tgtatctatg atagtgtcat 111540
tccttggtgt ttatgagaaa gagtgagaga gtgtgtttct ggatgtgtaa ttaaataaat 111600
aacatgtgtt cttttatcta acagctgaag caatggaagg catttgaaga ggaaaaccaa 111660
acaatcagac gcatggccaa atatttcagc actcccaaca aaagcttcca tacccagtat 111720
ggtgaggagg agaactgcca cccgagggga gagaaaagct ccatggagag gctcctcaca 111780
gaagtaagct ctgcccctgc ctggaagatt ccctgtaaag gatccaatca tgcatcggtg 111840
gcccccaagg ctcttattgc tgatgttctc ttttcctctc attctcccac ttctcttaac 111900
agcaagcaaa acctcaccat ttccaccgtg acacgcatct acttcattca ttcagtggac 111960
agatgtataa tgagtcactc ctatgtgcca ggcattgtgc cagtgaacaa tgaacaaaag 112020
catggttcct accctcacag agctcacagt ctagtggaag aaatagagat tcattcatca 112080
agcaaacatg taattataca ttgtcataag aattatgaaa gaaaaatcag agtggtaaga 112140
cagaataatg tgtggtaagg gcaagaaaac ataacttaga ccagtcagaa aagactcatt 112200
gagctgaggg ctgaaggtta agtacaaatt agccaggcaa agagtacagg gaaaagtatt 112260
ccaagctgcg ggaacagcat tgtaaaggcc ctgaaatgtg gtggacacta gcttccctgt 112320
gatacatttt ctctcttttt tttttttttt tttttttttg agatgaggcc tcactctgtt 112380
tcccaggctg gagtgcactg gtaccatctt ggctcactga aacctccacc tcctaggttc 112440
aagcaattct cctgcctcag cctcccaagt agctgggact acaggcaccc accaccatgc 112500
tcagctaact tttgtatttt tagtagagac ggggtttcac catgttaccc aggttagtct 112560
caaactcctg acctcaagtg atctacctgc cctggcctcc cagggtgctg ggatcacagg 112620
tgtgagccgc cgcgcctggc ctcattttct ctttttacat agagtagtgt cttcatgtcc 112680
aagatctcct ggggtcctta ctgtctttcc caggtactgg ctacagatct caatcagccc 112740
atcatcccag aaagtccagg catgtctaca gatggagaag gggactaaac aagggcttct 112800
gaatgtgatt gtagcaccaa gggagaatga ggcagctccc ccgggcttct ttcttctgta 112860
tttgagccag agttggcccc tctcccagac ttgggcagtg tgatgcaggc atgaagaaag 112920
cacgtggaaa ggtttgaagg cttcgttgac tcaggaagaa ggcacagggc ccaggggagt 112980
tagtcagtat tttgacacta actgaattac attccatatt ttttcagttt agaacctatc 113040
tcaggaggtg ttatttggaa aactgggctt tttttttagg actgctgcct aggtattaat 113100
agtccctgat gagaggatag tgtggtgggg acctagaaaa cacaacagat gaagggactc 113160
agcacaccca ggcacccacc gttcatgccc ctctatggtt ctggaccatt tttgtccatc 113220
agagtaacac ctctccattt ctttactatt aagtatttca aagccagatt tctttccacc 113280
tggcaaggga gtaatattgc ctttgatact ctgtgaagtc ttcaaataag catttttttt 113340
tcctggctac acagaaggcc agaaacttgg ctagaacagc caggatagtt ttcattcaca 113400
gtcagctgat gctggaacag ccaagtggac tgactcttta gccttatggt aatttgcaac 113460
gtgctgtttg tacttctgcc atgctaccct gtttcccacg cagggactca atctgctata 113520
tccaaaaaga tgctttgagt ctgcagagga agcccttcaa tgggcacagg tgcacaagtg 113580
gtaagaagct ggcctcccca gtgcacgcta cacctggaat ctctttccca gaacaggcca 113640
gagaacaagc ggccagtcct agggcccggt ggcaggtgtc aggaggttcc agcatctgca 113700
tccccagctc cagcattgcc cgttagagaa acatgagtat ctctcctggc tcaacatatg 113760
tacagacctt gactctggcc catggtgtgc agtgccttcc tgtgcaggcc ccactccccc 113820
actcaggcct tcctcttact ttcccgtgat ctgggcagcc ccatcttctc acacttttcc 113880
ctcttgcctc tatagccagg ggtcccccca gaagctgttt cggacagcat ctatcacatc 113940
tatcactgac ttccctgtct aagagaaggc cagcagacag aaccttccac aaggctgaag 114000
tgctttcctc atacactctg cagccaagta aacaaaccta ttacttttgt tacctgaacc 114060
atagaaacaa gaggctaatt ccatgtctcc ttatggcctg ccccctgtga aacatgcagg 114120
tggatgtttt gcttccctca atatgccaaa aataataatt aataagctca ttgaagtgca 114180
gctgccgtgg taggtcagat ttcagtctca taatggcagt gcctcacacc acacctctaa 114240
ttagtatgca gccatggtaa aaacagagtc ccacttcttt ttctggaaga aggaaatttt 114300
ctgtttaggt tgatgtttct aaatctgtca ccagccagct tcttcccaac tccatgttta 114360
tagtatcttt ctatactcaa aggagtttat agataaggca caaaaagaca gcactcagat 114420
ttcacccacg ggagtagttg ccatctgccg atgggtcctt cctaactctg tgaggctata 114480
gaggcctcca gaagcccaca tgagaatgtg cacgatgggc ttcaggagga gaggctggtg 114540
gaggagggag ttgaggtccc cccatgagat cctcagagag atgcctggca cagcccagga 114600
tcacaaacac ctgagtgttt ccctattgct catccattct gcccctgaca agtccttgag 114660
tcatctgcac tcacccagca acacccagac ctcaccactc tgcgggcaga gggaagggag 114720
ggaggacagg cacacatgtg ctcagctgaa agtctcttct accttactca ccagtccctc 114780
actggccctg gactctcttc tgatggtaaa agaagtatac tcaaccaggg tgaaactagc 114840
aataccaact atcagaaaaa tcaccttccc aattctacaa ggggagcagt gcatctgctt 114900
ggagagttgc tagtcagaat attggactat tttgcttaag ctactgctcc cttaaaggat 114960
catttctagg caactctccc atgtaaacct gagatgaaac cacaggttca ctctataact 115020
agtagtccta gttagctgtt atggacggta taactaggca atttgtattg gttatcctaa 115080
cacagggaac atccttttgt ttctagggca taataaatgg aggtccaaat gctcatgccc 115140
agctcctaaa gatgatagta acaaagaggt agcattttgg tgttcagaca agcactttct 115200
agaacatttg cttacattat tgccttccca gaaccctcga ccccatgtca tctgccccaa 115260
gtccagacgt tccctgtgaa tatctcctcc ctgctctgcc tttgaggatc agaagtttcc 115320
agagatggac acacagtctg aactagagaa tcagctgctg caccacagaa agatgtctgg 115380
gctgcagtcg ttccctgcaa cccactgcca acactcctac tcctacttca tgccccacaa 115440
tctcgcagtt aggacaggca cacctctgca gctctcacct gccagccctc tccggcacaa 115500
cttgtttacc agctaacatc cagcgagtag gcaggtcagt agcagaactg ccccaggctc 115560
cttcgtctcc tgggctccat tctagggctg ctgaatcaag ctagcagggg cttaagccca 115620
acagtccttt catttctttg tgcttcttca atagttctga tgcttgcact cctttaggtg 115680
agtggttccc aacatttttg gcaccaggga ccacttccgt ggaagacagt ttttccacag 115740
atagtggtgg ggggatggtt tcgggatgaa actgttccac ctcagatcat cagacattag 115800
cttctcataa ggagtgtgca gcctagaccc ctcacatgtg cagttcacaa tagggtttgc 115860
gcttctgtga gaatctaatg tctcagctga tctgatggaa gctcaggtgg taatgcttcc 115920
tcacccaccg ctcacctcct gctgtgcggc ctggttccta acagtccatg gactagtact 115980
ggtccgtggc ccaggagttg gggacccctg ctttaggtga aatcaacagc tgatattgcc 116040
acatggtagc tttggccact cactcccaga ggtccagcct agggaggtga taacaccaac 116100
ctgagattct ctttggcccc tctcagctcc aatcttattt gattgtcaca gaaatctcca 116160
cccttctcct tgttcttccc attttctagg ctgtttagta agaggcaaaa tacttgttct 116220
cctacttctt catcccctgg agatatgctt cacatttatc taaatttttg caaaagtgtg 116280
ataaactcca agtgggacca ttccaaacat tattcagctc atacctgcgg agtggcctga 116340
ccctctcagt tctgggaaag gtgagagggc gctgcagtgg ccagcaggca ctcagactgg 116400
gcctccttgc tcttcataag caatgccgca cagtgtgggg atgtaaggag aagaccaaga 116460
taatgacaat aaatcatggt tggcctttat tgagcaccgt ttatgtcagt tattgtgcta 116520
gcactttaca tgcatcaact catttcactg gagggaggca cctccttaga acctgaggtc 116580
accagccaat acactggaag aactgagatt tcagccaagg ttctttgaaa gccacacctt 116640
ctccaccatg gtgggcacta tggaaccctc ggcggcatct tttgttgatg gttttgcttt 116700
tattttacag aaaaatgctg tgattgaaag cctgcaggaa caagtaaaca acgccaaaga 116760
gaagattgtg aggctgatgt cagctgagtg cacctatgac ctcccagagg gggctgcccc 116820
acctgcctct tccccgaaca aggacgtcca ggcggtagcc tcggtccaca ccctggcagc 116880
tgctcagggg ccttcgggtc acctctctga ctttcagaat gatcctggca tggctgcccg 116940
ggattcccag tgcacttcag ggccctcctc atatgcacaa agccttgagg ggcctgggaa 117000
ggactccagc ttctccccag ggaaggagga gaagatatct gactcaaaag acttttctga 117060
tcatttagac tcaggttgta gccagaagcc atggactgag caaagcctgg gtccagaaag 117120
aggagaccaa gtccccatga accccagcca gagtctccta ccaganagag gcggctcaga 117180
tccccagaga cagaggcatc tggagaactc agaggatccc ccagagcggc ggtcacgggt 117240
tagttcagta atcagggaga aacttcagga ggtcttacaa gatctgggcc tgggccctga 117300
ggcttccctc tccaccgccc cctcttgtca tcagcaaacc tggaagaaca gtgctgcctt 117360
cagcccccaa aagatgcccc tctccaagga gctcggcttt agcccttaca tggtgaggag 117420
aaggcgggca gctcagcggg cccgctcaca ctttcctggc tctgcaccct catctgtggg 117480
gcatcgggca aacaggactg ttcctggggc acacagcagg ctacatgtgc agaatgggga 117540
cagccccagc ctggccccac aaactactga ttccagagta cgaagacctt cttccaggaa 117600
gccttcacta ccttcagatc ctcaagacag accaggtacc ctggagggca gcaaacaaag 117660
ccagacagag cccgaggggg ctagagggag caaagcagcc tttcttcgcc agccttctgg 117720
ttctggccgg gccccaagtc ctgctgcccc atgcctctcc aaagcctcac ctgacttgcc 117780
tgaacagtgg cagctgtggc ccccagtgcc ctcaggctgt gcctccctgt cttctcaaca 117840
cagctatttt gatactgagt ccagcagctc agatgagttc ttctgccgct gccaccggcc 117900
ctactgtgaa atctgcttcc agagctcttc tgactctagt gacagtggca catcagacac 117960
tgaccctgag cctactgggg ggctggcttc ctgggaaaag ctgtgggccc gctccaagcc 118020
tattgtgaac ttcaaagatg acttgaaacc cacgctggtg tgaaaagcaa cagagctggt 118080
ctagacacag aggtcagtcc aagagaagct gtaccaaggc ccacaggaga agagccaatt 118140
tctggtcttt ggggaacaga ttagtgccct gcatttgacc agcccatacc atgtttcagc 118200
taggctcact gtgttacttt gagtacttct tgatctataa aaagagaggc attgcctgtc 118260
ctgttactac ctcgcagcct tactataaaa gactccagtt gagtgactat gaaagacact 118320
gactccttgg ataaaaggtg ctgaatgaac acataggatt ttctgtccag gtcagcctac 118380
attctgtaaa actcttaata tattcagatg gatggctgaa tggacagaca gatggagaga 118440
tgcatgggaa atttctgtag aacttgaggt gtggactgtg acccatcaaa ctggcctttt 118500
ggtggacaga cctaccagga agataagtct cctacatcct tgggcctccc actcctggaa 118560
ggcagtggtt ttatttctgc tgaatgttgt gaacagcacc tccctagatt ccagcttctg 118620
gccagaccca gctcagagcc acccctacac cactatttct tgatggtgtc tttccaccat 118680
tatggcactt taccctcctc tctgagacag atctccatgc gcccgcaggc ttcccagatc 118740
tctcccctgg gatcggatgt acctgaggtc ctgactgtcc ccactgtccc cttgtcctgt 118800
ggctcatcct cgattcaccc actgatgcag ttttgtactg cggggaggca cacaccagca 118860
atttctgttg gggtatggga gaacctgttg gtcaagagtg cttttggttc cattggggtt 118920
acatgactac caacagacac ataaacctgg aagccaaatg gagaaataaa aaggaagaca 118980
cgagggacac gaaaacagga aagaaaacag gatttgaata tttcacttga gtccagcata 119040
gtacttggca atatcatatt tttgtgattc cttttgataa ccctgtgaag tagacacttt 119100
catttttaca gacaaggatt atgaggctta gagaaatgag gtagtttccc gcaacatcac 119160
actgctggac agagatgtac acacagctcc tgggactcaa gtaggtgggt tttcccaggg 119220
acacatggct tcatgtgttc ttctgggaat ggcaggtgac gcttggcaga cgagacaaca 119280
aagcaaggct catgtaagaa agctgggatg tgctccccta tagtccagaa taatagacct 119340
gggtcctcac ctcaggaaac gggcctccac ttcctcactg ccaaaggcca cactggcacc 119400
tcccaaggga gctggggagc tggtgaagga tgagtgcgag gaactcagcc accaccagag 119460
ccacagggag agcacacctg ggtccactgt gcttattgct gagctggctg tcatgtccag 119520
gctgtcccct gccccgagtc ctgtgtatac atctgtgggt gtgcacatgt ttgcatgaag 119580
gaattcaggc cttattaaat attctcagag gggggcattt ggctctaaat gtatcatcaa 119640
tttatcatgg aatcttgggg gctgctgaca cccctggact ctccaggcac tgaaccatga 119700
ggccctcctg gaagcacagc ttcttctatc atctactttt aaacaggaat ttcctaattt 119760
attctgtgca tgggtttgca gtttcttgtg ctgtgtgtgt gctgtccaag tggtaccata 119820
ataaaagaga aatgactccc gagaggagtc ttttcagaaa ctgtaatctg gggctggcca 119880
ggaggggccc ggagaaggct gacccaccca aagaagggga accagagaag ccatcagagc 119940
tgctgccggg ctaccctggg tcccagtgta ccttctacca aagttccatt tgaacagatt 120000
cttctgtgtt ctccctaaga agcctcttat cccagaaaca ctccctcaat ggacatagga 120060
aaccctggag accctggact cttcctgccc ctgggggtcc tgtggctggg ctccccctcc 120120
tgcagctccc ttcctcccag catgccacca ctagcagccc accattcatt catgtggact 120180
ctaaatctgg caatccttct agccttctca ctctgtctgc ttctagaacc ttagtcccac 120240
catccccgcc cttctacatc tccatccttc tgtttagaat tttttttccc actttgtgcc 120300
cttgtgaatt attcatcctt caaggctcag gtggagcata cattctttct tcaacctttc 120360
ccagccatcc ccaaagaaag ctgattgatt ccctagttaa ataaggaagg atgggctgga 120420
agcagtggct cacgtctgta atcccagcac 120450
<210> 10
<211> 120450
<212> DNA
<213> Homo sapien
<220>
<223> E533D GPR156 GAC genomic DNA
<220>
<221> variation
<222> (117166) .. (117166)
<223> n is a, g, t, or c
<400> 10
ggggaccgtg ggcgtcctgc acatagcagc gggcttggcg cttctcggcg gtccgacgct 60
gatgaggtga gcacagcgac cttaaggatc cacaaaactt caaacactta attattaagt 120
gaaagtggaa agggggaggg gctttctctc cctttccaga atctgggcag tttgtttgga 180
accggtaaag aaactctcat aggaacttga ggtgagcagg ggtcacgcat cagggatgcg 240
agtggcaatt tcagtggaag agacgggaga gtactgtaat ttggtgtgaa gatggggccg 300
tgggttttct gctgaataag cgaccggctg tgctgaaaat gagagatccc gaaacagttt 360
cccaccgcct gtagactttc cagagtctcc tcacgccgaa tctgctttgc agggcatgtt 420
cacccccagg gtgtagagtg gcgggcacga tgggctcccc catggagatt gcaaagtcct 480
gaaaagggac aattgtattg cactgcgtct gttgaactgc cttgcttctg ggcatgaggg 540
agtcacctgg aagctgcaac atccttgtac cctggcaagc agccctttcc aagttagctc 600
tgtcagaaac tagaggcctc taggtagaac tcaaggtatc catgtactcg tgaagaatac 660
aaaccttgag gtttttaaaa tcgaattttg ttaagatttc aggatagaaa tctgggaaga 720
gaagtcatgg catggcataa cttacccctt tgttagtttt ctaggtacat gcatgcttga 780
attagaggta aatgatgccc tagcctatca taaaatgtct ttcctggtgt agttctttaa 840
accagaatat ggaggataac attacatttt tgcatcctag ataaaaggga aagattttca 900
gatggggctt acacagcggg agaaattgtt gatatagttg tattaggcag caaggcctgc 960
aaagaaaaac ttctttttct ccaccagtgg ctgaattctg cacagaatgt ctcctcgcag 1020
tctgggtagc agcccggctt gcaaaaacag tgcttctttc attgctgcag gtggggcaaa 1080
tgcgcttgcg gataaatggc tggggaagcg tttgcttaca ggttaaggca atttgagtct 1140
ggagaataaa gtgctttagc aggctgtgct tgagttaggt gtcccttgtg aggaatagag 1200
gtggctttct ggtccccatt ttgccagcct aattcccctt cagggacact actgtctctg 1260
gaatgttccc tctgtttccc cttctcttcc acccccagct tttagcttct ccccattccc 1320
cagtaaagtc tagaattgag cctggtcaga gtcaaagttc tgatagccta gggatataga 1380
acttcaagcc tggtgaaggc agaaatgaga cctaggagag acccaagatg ggtgagatga 1440
aacaactttc agcctagaag gctctcaaaa gagtggaaaa ataatgattg agggaaacag 1500
attctctgga aaggagaata ggtgcttaag tgtttgtttt cagctgaggg ttttaatatt 1560
tccatttttg ttgtttaacc ataagggaat ttccattata gggtaggagg aggatgaggc 1620
cttctctgaa aactgcatcc ttctccttga atttgcattt tattccattc ttatgtaggt 1680
ttcagagatt aattggggga agggggagag aggaaagaag ccagaggctc tgacatgctg 1740
cagaaacagt gcaacgtgga ctgacttggg ctgcaaaggt ggatttgggg gttgaaagaa 1800
atgttctaca tttagttgaa aaaaaaaaat cagagccttt attttgcaaa ggtcttgaga 1860
atcagaacat tcatgtttag ttgctgatga attttgcctg ataaaggatg caaatcacta 1920
tctcaccttt ttttctccag tactttatta tgaaaaattt tagacataca gagatgtttt 1980
ctacctctca ttttataaac ttattatctt aaaacaaact tgttaataaa aatcagtgtt 2040
tagaatccag acatatgtga tctggtcctg gacagagctt gaatcagaag gtgtttcaaa 2100
tatagatgtg tgaaggatat taacatttta agaaaaaaat atggatctta ttcttctgac 2160
tttcccataa gaatcttgag cagacccctt aactgccttc tttttcccat tcttaaaatg 2220
tcagtcagtt ggatgatatt actctcctgc ttaacaccct ccaatggctt cccctcacac 2280
tgtgaataac attcaactct ccaccagggc ttgtgatttg gtctggtgcc ctcatattct 2340
atggccgtcc tcttgcttac catcgtcctt gctcttccct ctgcctgaac actcttcctt 2400
cagacactgc cactgcttct tttctcagct cattccagtt tcttttcata ctctccagaa 2460
tgatggccac ctgatctaaa acagcctgtg gtcactccct gtcttctgac cctgctttat 2520
ccttcttcat ggcacttagc actccctgac actatatagt atatgtgttt ccttgttaat 2580
tgggcatgtt ccccactcta atgtaaactc catcaagaca aggaattttt ttgtcttatt 2640
tatggctgtg ttcctatttg gtatattatg agcaattaat aaataactgt tggattaatt 2700
aggtaactaa attacacaaa taaggcattg actcccataa gggtggcaga acccttggta 2760
aaatactaga agtcctttga ggtaattcat aattcaagtt aatcaatatt tgataggtaa 2820
atgatgaccc tggagatcag tggcctcttt tatcctcaca gcacttctca gctgaatcct 2880
atgctaatag ctggccagtt ttgacaaacc cacatcccaa acaagacata aaatatttca 2940
gtcacagaac ttttcctcac gtctctttct agtcacctcc accccacaga agcagcaaac 3000
cttgttctga tttctaatat catagattag tgttgctggt tcctgaattt catataactg 3060
cagttacaca gtatgcactc ttgtgtttgg cttctttttg ccctacacaa tgtctgtgat 3120
attcatctgt gccattgtgt gtatcagtag ttcatttctt ttttttccaa ggtagtattt 3180
attgtatgaa tattgaccat gtgtttatct gttctcttgt tgatagatac ttggttgttg 3240
ccagtttgtg gcaattttga acaaagctgc tgtgaaccta taaagggtct gcctcatctt 3300
gagtcttctc tactttatat gaaaatcttc cttgtgccac caatgcagag agaagtatgg 3360
caaggttatg ggggctgtga ctgatgtagc agcttgcatg taccccagcc agtgctctct 3420
ctagacagct ctgctgggag ctgacctgct tcccacttta gagggaaagc acttggaaaa 3480
tgagtgtcta acaaattagc gagccctcca gtgcactctt aagtgcttta aatccttgaa 3540
agagacactg tggaatgcct gctgccatca ctgttgtatt tccctcctcc tctcagcttc 3600
cccatcccag cacaagttga ctctaatcag cttctgagca ttatgctact gaggggttta 3660
aacattcatg agcaagagtc ttgttcagag cctgataaaa tattcatgtg tttccatggg 3720
gcattggttt ccatctagac ttctcaaggc atttttctga gatgcatgtc gtaattgtga 3780
agaactcaga cagtgatgga tgatacggcc ctgtgttatt aaaccctacc acacagagca 3840
ccttgctttc tagggatgga gaagaatgag cacacagaaa aattgacatt aatcctgtct 3900
agatcaagag aaaggctaca tgtactgata aaaatggctt gagtaaagag gggcctgtta 3960
atatagtacc aacaaaggta tgaatccata gaggagagtg aaaagaactt gttaaaatga 4020
gaggaatgct gggatgcagt cattccaagt ggaagaatgg gggaatcagc attgtaaaat 4080
gcacagttcc tttgacactc atgtggacga ggttcatatg agacaactgt gctgagtgct 4140
gtaattatca caacctgcta tgagaggatg agagtagaag tggaggctag gcagggtttc 4200
caagtagagc cagagagcta ttccaagagg agtcaacatt tctcttcaag gaagaagtgg 4260
ctttgagtca ggttctgaag gaggtgtgcc tctttgactg gcagctgcgg tgtggaaggg 4320
actttccaga gagacagaat agcatgatag agtgagggcc aaagtgccgg tgtggtgtga 4380
gtaaggagag aaggtgggtg gatgggggtc agggcagggt tgcagcaaga cataaagcag 4440
gagagctaaa ggccagctta tgaaggccac aggaggatgg acttcagtct gtttgctgga 4500
gggccgtgta acttttggcc agagattggg ttacattttg aggagttctt gggaagtata 4560
tccaccctag gcaaggcctt gaggtatgtt tatgtccaag gcatttccag aatattctgc 4620
tgtgtccaga acactatgaa gactctacgt ggtctactct aagagaggta aaccagagga 4680
ggtcagatat actcagtata ctcctgggac tgaccagaaa caggcctcac caggcacctc 4740
tctgccccca gcacacaaac actcagaata ttctgagtca gattgaatcc acagcattcc 4800
ctagacttct tcatgaccac tttgcctcag ctgggggagt tgcaatgatc taagtatccc 4860
cttatcacct gaatctgggc caggatacct cagacatggg ttgccaggca actgagggct 4920
aagtgatgca gctggccaat catccccaca aagcccaggt ctgctttgac caggccatcg 4980
ggctgtgacc agagaggcaa cttggggggt tgaggtcatg cagactgatg acttgtggac 5040
acaactgcca ggccccttcc atatgtcttc ttcctttggg ttgcagattt ctattcaaaa 5100
atgcctcagg atgttgattt tttaacccat aataaaaata gtgaagtagg gaggagtgtt 5160
aaacatgtca gtcatctata ccttatgttg tcattgggaa gaaataactg tggaaacaat 5220
tgtcccggga aagtcagtct tcagtcttgc agtgaggagc tttgcatatg tggagattag 5280
ctagaaagct ctggagttct gatggtgaga agggatttct tgggtcaagg ataggaaagg 5340
gcaagggagg accttcatga ttctccccag ggctttgctg gttggaattg ctcttctgct 5400
gccatgggta gcatggggtt tcagtgactg aaaacaccca ggaaagtatg ctctgggtct 5460
tcatgttgcc atctgcctac actggaatgt cagaccatca gtcagcactg ccagctctcc 5520
atcttgattt tctaagagtt attgagaaaa ccttgaaagg gaaggcagaa gtgggtgtct 5580
taactaggga aatgccaagg tcctaaaggt gtggtctagg ttgaaggtgt ggtaagggcc 5640
tgaagtcatt ggtctggcag tacttcagac caataaagtc tttcttggct cttatctaaa 5700
atattcctga ttttctgtgt gaggtggaat ctctcaagtg ctgcattaat cagtcttttg 5760
gctgaacagg taaatagggt gcatgcttaa ttgagtgcct tttctttttt taaagtttca 5820
gcttttattt tacattaaga ggatacatgt gtaggattgt tcatgggtaa attggaccca 5880
ggcataagca cagtacccaa taggtagttt ttcaacccat gccccctccc tcccttcccc 5940
ctgtagtagt ctgcagtatc tatctttcct gcgtttatgt ccatgtgtgc tcagtgttta 6000
gctcccactt ataagtgaga acatgtggta ttttgttttc tgttcctgca ttaattcact 6060
taggataggc ctccaactgc atccacgttg ctgcaaagga catgatttca ttatttttta 6120
tcctatggtg tttatgtagc acattttctt catccagtac actgttgatg agtgcctagg 6180
ttgattccac atctttgcta ttgtgaatag tgctgtgatg cacatatgca agcatgtgta 6240
tttatggtgg aatgatttat atttctttga atatataccc agtaatggga ttgctgggtc 6300
aaaggtagct ctgtatttaa gttttttgag aaatctccaa actgctttcc acagtggttg 6360
tactaattta cattcccacc aacaatgtat aaatgttccc ttttcttcac agccttgcca 6420
gcatctgttg ttttttgact ttttaataat agctattctt actggtgtga gatggtatct 6480
tattgtggtt ttatttgcat ttctctgatg attagtgatg ctgagcatgt tttcatgtct 6540
attggccaca cttgtatgcc ttcttttaag aagtgtcttt tcatgtcttc tgcccacttt 6600
ttaatggagt tatttgattt ttgcctgttg atttaagttt cttatatatt ctggatatta 6660
gacctttgtc agatgcatag tttgtgaata ttttctccca tgctgtaggt tgtttactct 6720
tttgatggtt tctcttgctg tgcagaagat ctttagttta attaggtccc acttgtcaat 6780
ttttgttttt gttgcagttc tttctgggga cttggccata aattctttgc caaggccaat 6840
gttgataagg gtatttccta ggttttcttc tatgattttt atagtttgag gtcttatgtt 6900
aaatctttaa tccattttta gttagttttt gtatatggtg aaaggtaagg gtctagtttc 6960
attcttctgc atatggctac cagttatccc agcaccattt attgaatagg gagtcctttc 7020
tccattgctt gttttttgtc agccatgttg aagatcagat ggttgtaagc gtgcagcctt 7080
atttctgaat tttctattat gttccattag tctatgtgtc tctttttgta ccagtaccac 7140
cctgttttgg ctactctagc aaattctttg gaattaagga aaatagggac acaatttatg 7200
aagacctctg ggatgtagcc aaagcaatgt taagaggaaa gtttatagcc gtaaatgcct 7260
tcatcaagaa gctggaaaga tctcacatta acaatgtaac tttgcattta aaggaactat 7320
gaaaaaagga caaaccaacc ccaactctag cagaagaaaa gaaataacta aaattaaaga 7380
aaaacttaat gaaattgaga tgcaacaatc catatgaaag atcagtgaaa ccaagaatag 7440
gctatttgaa aaaataaata agattgatag actgctagct aggttaacaa agcgggagga 7500
gacagtgaga gagagagaga ggatccaaat aagtacaata gaaataacaa agatgacatt 7560
acaactgatc ctatagaaat acaaaagatc cttggagaaa actatgaaca gctctatgca 7620
cacaaattag aaaatctaga agaaatcaat caattcctgg aaacaatctc ttgagattga 7680
atcggagaga ttgaagtcct gaatagacca acatcaaact ctgaaattgc atcagtaaaa 7740
caaacaaaca aacaaaaaaa acccttccaa ccataaaaag ccctggacca gatagattca 7800
cagccacatt ctatgagaca tgcaaagaag aactagtacc aatcctacta aaacttacag 7860
aaaatagagg agcagggact cctccccaat tcatcccatg aagccagcat cagcctaata 7920
cccaaatctg gcagagatat gatgaagaga tatgattttt gtgtctatgt tcagaccaat 7980
atccctgatg aacatagaca caaaaatcct caacaaaata ctagcaaacc aaatttagca 8040
gaacatcaaa aagttaattc accatgatca agcaggcatt attcctggga tgcatggttg 8100
gttcaacata cacaaatcat agtgagtcac catgtaaaca gaattaaaag caaaaaccgt 8160
tatgatcatc tgtgtcatct caatagacac agaaaaagct tttgataaaa tctaacatct 8220
cttcatgata aaaactctca acaaactagg catcgaagga acatacctca aaataataag 8280
ggccatccct gataaaccta cagctaacat catactgaat gggcaaaagc tggaaccatt 8340
ccccttgaga actggaacaa ggcaagaatg cccactctca ccactgctat tcaaggtagt 8400
gctagaagtc ccagccagca cagtctggca atagaaagaa ataaaaggca tccaaataag 8460
aaaagaagaa gatgaactat ctccctttgc tgacgatata attctatact tagaacaccc 8520
caaagactgt tccaaaaggt tactagaatt gaaaaatgat tttagcaagg tttcaggata 8580
caaaatcaat gtacgaaaat cagtagcatt tctaaacacc aataacgtcc aggctgagag 8640
tcaaatcaag aacatgatcc catttacgac agctgcaaag aaaaggaaat acctaggaat 8700
atagcaaacc aaaaaggtga aagagctctg caaggagaac tacaatacac tgctgaaaaa 8760
aagttagaaa caacacaaat aaatgaaaaa atatcccatg ctcatggatt agaaggatca 8820
atatcattaa aatggtcata ctgcccaaag caatgtatac attcaatgct attcctatca 8880
aactactaac atcagtcttt acagaattag aaaaaactat tctaaaactc atatggaacc 8940
caaaaagagc ctgaatagcc aaagcaagcc tgagcaaaaa aaaaaaaaca aagccggagc 9000
atcacactac ctgagtgcct tttctgaaca gatatttcaa tgattctgtg attattcatg 9060
agccagtgat ggctgcctgc ttttggatgc tgctaggata aatgcagaag atcagagtga 9120
agagggagag ggaagcataa cagcagcaga gaggaaaagg gaagagagta gtgacgtgct 9180
gaaatcgcag agattgtggg tacccagtta tctacaagtg agaaacaggg ataaaagaag 9240
atcaaataac tacccatggg aattttacat gcaaatattg ctgacttcca aggcagctgt 9300
gaggagaaag gaagggagga gacacaaagg cagctgtcac agtcaatccg aggaatatta 9360
ataaaaactt gacacatgaa aacacatggc cgtatcacaa cagcctgggt cccagcaagg 9420
atgtctattc aaacccctct ttcacatttc cttatattca ttcacagtat taggtatttt 9480
gcaagacatt catttgcact tgcaaagata cacaaatgca gagtacttaa aagggtaaac 9540
tatcctaaaa tattagtggt gagattataa atgattattt gtattttttc aacttatcta 9600
tgttttccat gattgtttta agaagtgtga atttctttga taatcagaaa aacattaagg 9660
agaaaggggg ttaagtaggg aggtagagaa agaggcatgg ggtggggaga gaggattgta 9720
gaaaagaaaa atatgttgga agatgaatga acaattttaa aactttatgt ttcacagact 9780
gctagcttgt gcatattttt ctttattatt gaatatatat gtttatcacc ctcagaagat 9840
ctggaagtac caattggcat gaaactgaat tgcaaatact gagctaagta tcacacctcc 9900
aagaccattg ccttggccag tgccattctg tgtgtgacat gtggcttcca gtgatgctca 9960
aagtattttc cgccaaaggc taatagagaa cacttcaaac ctgggcagca gcatctctcc 10020
cacagggttt aatatttata cttgtagcca cgtggctggc tttgtgcttc tcatctctga 10080
agtatggaac aggagccaac aaaggctgtc aatagttgga gtagtgggat tttccaagac 10140
aaaagcgtga gttattctcg tccacgtgtt tgctggctgc tcactggctc aggcagcccc 10200
ttggcaagct ctgtggctga ggctttaaat aaatagatgt agtttttgtt tcacaaccac 10260
tgaccttttc tggaggcact gttgattctg ggctttaatt ggcttctgtt gagtgacaca 10320
aggtgaaccc tctcttcaag agcagaagct cctatctgct gttaaccacc agcatcaatt 10380
caaagcaaat gccagaggac cacatacctc actgaactct ggggactggg gttacttgta 10440
gttatgtctc aataaatact ttttatattt taacttttgc atttttaagt tgtaaaagct 10500
atacacactc atggtaacaa gtctagtaag acagcagtat ataaagaaaa tatggccagg 10560
cgcagtggct caccccatag ttccaatact ttgggaggcc gagatgggtg gatcacttga 10620
ggtcaggagt tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatta 10680
ggctgggtgc ggtggctcac tcctgtaatc ccatcacttt gggaggctga ggcgggtgga 10740
tcacaaggtc aggagttcaa gaccagcctg gccaagatgg tgaaaccctg cctctactaa 10800
aaatacaaaa attagctgag cgcagtggca ggcacctgta atcccagcta cttgggaggc 10860
tgaggccgga gaatcacttg aacccggggg gcagaggttc cagtgagccg agatcctgcc 10920
actgcactcc agcctgggcg acagcatgag actccgtctc aaaaaaaaaa aaaaaaaaaa 10980
attggccagg taaggtggct catgcctgta atcctggcac tttgggaggc cgaggtgggt 11040
ggatcacctg aggtcaggag ttcgagacca gcctgaccaa caaggtgaaa tcccatctct 11100
accaaaaata caaaaattag ctggacgtgg tggcaggcgc ctgtagtccc agctactcgg 11160
gaggctgaga caggagaatt gcttgaacca gggaggcaga ggttgcagtg agccgagatc 11220
gcaccactgc actacaacct gagcgatgga gcgagactct gtctcaaaaa aaaaaattag 11280
tcaagtgtgg tggcgtgtgc ctgtaatccc agttacttga gagggtgagg cgggagaata 11340
gctcgaaata gcttgaaccc aggaggcaga ggttgcagtg agccaagatt gtgccactgc 11400
actccagctt gggctaccga gggagactcc atctcaaaga aaaaaaaaaa gaaagaaaat 11460
ataagtaatc tccaccttct ctcactccca tctttctgac aaaaccacta tttaaagcgc 11520
ccaggctggg cgtgcgggct gacatctgta atctgagcac tttaggaggc agaggcagga 11580
ggatagcttg ggtccaggag ttcaaaacag cctggacaac atagtgaaac tccgtctcta 11640
tgaaaaaaaa aaaaaaatag ccaagtgggt ggtatgtcat cctagctact tgagaggatg 11700
aagtgggagg atcgcttgaa cccaggaggt tgaggctgca gtgagctgtg atcatgacat 11760
tgcactccag cttgagtaac agagtgagac cctgtctcaa aaaaaaagtt tcatgtgtat 11820
tcacatgtca cgatcacagc tcactgcagc ctcaacatct ccagctcaag ggatccttcc 11880
acctcagcct gccaaataac tgggaccaca ggcacatgcc accacacccg tctaattttt 11940
aaacattttt gtagaaacga ggtctcactg tgttgcccag gctgatcttg aattcctcgg 12000
ctcaagtgat cctcccacct cagcctccca aagtgctggg attataggca tgagccactg 12060
cactcagccc cttcactcct tttctatgtt caaacaaaca tatgagtgtg tagacttatt 12120
ttctattgta tgtgaaaatg gaatcatata tgttattatt tctttcattt tatttagtac 12180
atattatgta cattattcta gattaacaca tataattgat ccaatttatt atttttaata 12240
gctacctaat attccattat aggaggttcc ataatttctt cccattcatt acttccccat 12300
tgatagatat tcatgttttt cttccaactt tttttgcaca acaacttatg ctacaataaa 12360
cattctacat ttattcctat actttgggtt ttatttccat aggagagatt cccaaaattg 12420
tcatttttgg gtcaaaggga atacacaatt ttaattctca ctgtaggtct cctttacagc 12480
agttgtttct ctcctccttt tgtctttctc tcccctctcc caccacattt tgccagcagg 12540
gcctgtgtgt ttaagaagga aagcctgcag tgagaactcc tctgtgccaa gtgtggatta 12600
tatcagctta gtggggaact ggagtctgca gtgtctcagt tacattgtgt ctctcttgct 12660
tttggttggc cagactgttc acaattcccc ttgctgattt attccatgct gtggaattat 12720
acatggtctt catccgtggc aggatcatct gaggggtggc tttttgggaa gggtgtcttt 12780
tcagaaagaa taggctcagt tactgtactt tctcacaaag ctatatctgt tatgtttttt 12840
tgttatgccc tttctttaat agttggattg aaaaaggttc ttcaattccc atcccggtct 12900
tctgtcttca ttttgaggac ttgggattta gggagtttta tgagtatata atcaatcaac 12960
tgtaactgat tatttgacat gaggataatt agttaagaag gtaggggtct tggagcttaa 13020
ggatcagtgc caagcaacag acgtgaacat ttttaaacaa atggttttaa caaacccggt 13080
attaggagca agcttcccag gagtactaag ctttcatttt ttaattttgc ccttgctggg 13140
atgtaaaact tcagtctagt ctaccagaat agagaggagc tggattctcc accacaccag 13200
ggctggagag gagaaaatgt cagagaagcg ttaagggaag ctggtaagta caaataagtg 13260
aaataaatat aaacagtgaa ctgacaaaat ggcaaaaagt gaatgaaatt tgaaaatcct 13320
cagctgaaga ttattgtgta accagtggtc ctgtgagcta gtggacactt tataaaaatc 13380
tgtgatctct aaaacatatt agatacccca gtgtgaatct gtgttcagaa tacaaccatt 13440
agctaagcaa gacagagaaa tgataagtcc tgttggcaga tattttgcta ttgacttcta 13500
taacatatgc tgcaattttt actcagcagc tttggaatgg atttctatgt cctaggttga 13560
aaactaaact aaaagaaaaa cagaatagaa gttactgcac ttaatttcta aggagaaaat 13620
tttaacttta gtttgtgcat gtatatgcct gcaaaataag cattaccctt tatgttaata 13680
caaacttcac atgaatgttt aattttcaaa tatgcactga ccagtaataa tgatggcaaa 13740
attagactct atagtaggtt tatgttttat aacttaggga ttctataatg tatcttagtt 13800
gatgtcgtag ttaatagtaa ggatagtaat atcttataca gtttgcactg tcgtctgagt 13860
aaagattatc tttaaacatt tgttcctgtc agaaaaattt taaggctaaa cctattataa 13920
gatattaagc atctgatttt ggctataatg gactatctgt gagtagattt ttactcctat 13980
acaggacatc tagaaaagct gagttttaaa aatctatttg aaggcataga agacctaata 14040
aggcagctag gacttgagag ctaagacctc agaaagaaga gaaactcatt gagtgttcca 14100
aattctaggc tactttttcc ctgtagacac ttaccatttt taagtagcac atgaggagaa 14160
cccaaacaat aagcagctgc taaaatcaga gaagccaggc agattattcc acagtctgat 14220
agggctgggg aggaaaaaaa aaaattgaat tcaaggaaac caaatgattc aggacatgag 14280
aaaccatgat catggacaga aaagaggccc agaaaaatca actcaatagt ctaagcaatt 14340
ttccttccaa gtcattcact gatttataag tagcgcagac caagaggttg caaaaatcca 14400
aacacaaaga aggtgctaaa aagctgagaa gctaatcaga gctacttgca atcttattac 14460
actaggaaga taaaaattat tatagaatgt aaagcccacc aatgtggtat ggcctgaaaa 14520
acaccctaag ctttcagttg ggactgctga cggattatgc ctgaccagtt aaaggaaacc 14580
agaaatagac ccggtcaaat aaaatattga agtccatttc ccgatcaact tagtcactga 14640
ttagattaaa gtaatctgtt cttattttaa caccctagca taagtcttct ccatattctt 14700
tggagaagaa aaaatgatcc agaacctgtg tatttttcat atgtggtttc tggtattcag 14760
caaagcaaaa caaaacaaaa acaggcatac caagatatag tttccagaat atggtacaga 14820
gagaacccag acttcctgag ttgagaagac agagctcccc atgtctgggg agaccagggc 14880
aactagagtt tgtaggacag agtattggag aggagagagc tgcagagaga accccagagt 14940
tcctcacagg gtacacctca agtataaagc tgagtactga gcagcacatg catgtaagga 15000
aactacctgg gataaagaaa gaactaccca aaaggattag aagaaatagt gctcattgtt 15060
cacacagggc tgggaattgt gcctattccc accagctaga cttgaaaagc tcataattca 15120
tggagggttg ggtagtatac tttgaaagac catgccttag tagtgggaag tagccctaga 15180
ttgagcactg cactgatcct gtctaacaaa tcttttaaaa agacccaaaa ggaacaaatt 15240
gttccagtta atttgactgc atcccagaac aaagctcaaa actatttaga ggtatttgga 15300
atagcagtat tagtaatatt gcagagggaa gaatattgcc agggataaag aaaatcattt 15360
cataatgata aaggagttga ttcatcagaa agacataaca gtactaaaca tttatgcatc 15420
taataacaga acttcaaaat acataaatga gaaattgata gtgttccaag gaggaataga 15480
caaatccata actgtagtcc aaagtttcat taaccttctc tcagtaattg atgaaataac 15540
agaaaataat taggtatata aaagaagata aaaatacaat caactagctt gacctcattg 15600
atctttataa gatactctac ccagctacag caaatacata ttcctctcaa gtgtacatgg 15660
aacatttatc cagttagacc atattctgaa ccataaaaca agtctcaata aatttaaaag 15720
gattttagtt atataaggtg tgttcttgat cacaatggaa ttaattaaga aatcagtaac 15780
aaaattctca aatatttggt aactaaataa catccttcag aataactcat tagtcaaagg 15840
agaaatcaaa aggaaaatta gggccgagtg gagtgactca catttgtatt cctaacactt 15900
tgggaagttg aggcaggagg attgcttgag gccaggagtt gaagatcagc ctgggcaaca 15960
gagtgagagc ctgtctttaa aaaaaataga aaaaaaaaat tagctgggca tggtggtgtg 16020
cactcataat cccagctact tagctggagg attgctttag cctaagagtt tgaggttgca 16080
gtgagctatg atcatgccac tgcattccag cctgggcagc agagtgagac cctgtctcta 16140
aaaaaattat ttttaataaa aaataaaggg aaatgagaaa atatttgggg ctgaaagtaa 16200
aagctcatat atcaaaagca gtacttaggt ggaattttat agtattataa gcttataagg 16260
tggggcacag tggctcacgc tggtaatgcc aacactgtag gaagtcgaga caggcggatt 16320
gcttgaaatc aggagttcgg gaccagcttt gacaacatgg caaaaccctg tttctataaa 16380
aaatacagaa aattagctgg gtatggtggc acgtgcctgt agtcccagct acttgatggg 16440
ggctgaagca ggaggatcac ttgagcccag gatttcgagg ctgcagtgag ccgagatcac 16500
accactgcac tccactccag cctgggtaac aaagtgagac cctgtccccc cacacccccg 16560
caaaaaaaag cttataagaa gaaaggtctc agattagtgt cctcagcttt catcttaaga 16620
aaccaaaaca gaaaaagagc aaatgaaatt caaaataagc agaagaaaga aaataagaaa 16680
tatcaaagca gaaatcaata aactagattt tgaaaagtag agaaaatcaa tgaaagcaaa 16740
tgctgtttca ttgagaatat taataaaatt gattaacctc ttgacagaaa acaggaggag 16800
gaaaaagaga ggagttacaa tttaccaata tcggaatgag agaggtgaca tcactacaaa 16860
ttctacagat actaatggat aataaggaaa cattatagct tttctccaat aattccatca 16920
acttattaat agatgaaatg aacaaattcc ttgaaagaca caagctacca aagttcactg 16980
aagaggtagt agagaatgta aaagcccaga tctattatag acagtctcga aagttagaaa 17040
tagaagagaa cttccctagc ctgataaagg gaatctatgc aaaacgtgca cctaacatca 17100
tatttagtgg taaagcaaat agtaatataa tcgatttttt ttcttttttg agacagagtc 17160
ttgctctttc acccaggctg gagtgcaggg gcgcgatctt ggcccactgc aacctccacc 17220
tcccgggtcc aggcgatctt cctgcctcag cctcctcagt agctgggatt acaggcacat 17280
gccaccacac cctgctaatt tttgtatttt tagtagagac agggtttcac catgttggtc 17340
aggctggtct tgaactcctg acctcgtgat ccacccacct tggcctccca aagtgctggg 17400
attacaggcg taagccactg cgcccagctt tttttttttt tttttttttt tttgagatgg 17460
agtcttgctc tgtcgcccaa gctagagtgc tgtggcgtga tcttggctca ctgcaacctc 17520
caactcctgg ttcaagtaat tctcctgcct cagcctcctg agtagctggg attacaggtg 17580
cccaccacca tgcccagcta atttttttat ttttagtaga gaatgggttt caccatgttg 17640
gaccaggctg gtctcgaact cctggcctca ggtgatccgc ccaccttggg atcaccaagt 17700
gttgggatta caggcgtgag ccactgtgcc tggcctgcct agacttttaa cttatttgtg 17760
taattacttc aagtatagat tactccaatt taaacacaaa gattgtgaaa ctagatgaag 17820
aataaacata ttcaaaatga ttattaaatg ttttaattgg tgacagagtt tttcatagcc 17880
ttttatcatc tcagtgcatc atgttttatt tgtaggtagc cacagagaaa cagctacatt 17940
tataagaaca ccatgaagaa taattaaaat gttctttttt tttttttgag acagagtctt 18000
gctttgtcac ccaggctaga gtgcagtggc aagatcttgg ctcactgcaa cctctacctc 18060
ctgggttcaa gtgattctcc tgcctcagcc tccctagtag ctgagattgc aggtgtggac 18120
cactacacct ggctaatttt ttgtattttt agtagagatg gggtttcacc atgttggcca 18180
ggcttgtctt gaactcctga cctcaggtcg atccacctgc cttggcctcc caaagtgttg 18240
ggattacagg tgtgagtgac cacacctggc ctaaaacatt cttttatccc tgacttcagc 18300
tgagtttagt ttgaaatgag gctctttatt tggggtgatt gggctttgca ggagggttgg 18360
tgggtggcct ataattcccc ccaatattgt atgtaagata ttacatgttt gtatacagtt 18420
tttcaggaga gagtccgtag ctttcatcag tctctcatga ccaaaaacta tttaagaatc 18480
atggcttgaa gaatgaaaga atcgagtgcc atgttaagtg tctaatttct caataatact 18540
tccctgaaac taatttctag agaataattc aaatgacttg atctaaatat gtgtgcatga 18600
gtcatcaaag cagcctggag taacatatta aaagttatcc caagggtctg tctggttcaa 18660
actctgatga aagccctata tttcttatcc tggactgggt ttctcatagt atgattccca 18720
gatcagcagc agcatcagca tcacctagga acttgttaga aatacaaatt ctcaggccgg 18780
ccccaggcca tacctactga gttacaaatt ggagatggga ccaggaatcg gtgttttcta 18840
aggagctttc caggtgattc tggtgtgcac taaagtttga taaccactgg gttaggctat 18900
aattagaaaa tcctgttctc cgccccgctc ccaagccagg tttagaacag tttgttaagc 18960
aagtatctgc agaaagacca gtctaatgtt gacagcttct attttccatc tttatggaaa 19020
aatcgtaaag cctcaaaagc ccaaatcacc ctcacacaag tgtcttgggt tgcacagcaa 19080
caccaaacaa cagtttagag taatccaatg tccagctgaa attggaatta tagagacaca 19140
gcatgtgagt tcactcacaa aaatttttac caggaggctt tttagggatg agccccgtaa 19200
ttccaagggc cttggctctc agcctccttt gaggcatata acacagtctc ttgaacagac 19260
tgaccctcag taatgaggtt tcattaccct cttccagaca tgtggcaccc tcacaaacat 19320
cctttaacag agtgctcagt atcaccatgc ttcgtttgca aagtaactta atgaattcgc 19380
tcagcctata ttcttagtac ccagtggtag ggatctcagc tgtagcagca taaaacttga 19440
actgtccaaa accagtctct gaaaccttca agtgtttatt ctgtctactc ctgctgttgc 19500
ttgaagcttg atttgttgtt acaccttact gttttgctga tgagaaatag cacagggtac 19560
ttctcagtgg ttctcattaa aggagggcag ccaagtggaa ttcattcttg gctcttaata 19620
gttttcaaat gagaatttta ttgcatacta atgagcacta attgacattt gtgactgttt 19680
tttatggaaa taatgcatgt acaatttgca taatagtacc taagtgcttt taggtaacag 19740
tacaactctg ggaagttggt gaaggttttt gtatgatgct ttttaaaaaa gttcccaaac 19800
cccagcccct agaatagtat agaatattaa caggtctctg ggatccaaat ataaggcagt 19860
agtagtgact cagttcctgt agttgtacca gcttgtacct gagagtcaga aaatgcatca 19920
gggcaggtct ctaaaagcag gaagcgctcc cacagtagcc agggaggatg ttccagccct 19980
ctctaccttc atgtgtcaac cctcctgctt ctcctaagtc atgagtatct agacagtgct 20040
gaggattgtt ccaaggactc ctacactgta aaatgttttc taaacatcac ttggttgata 20100
tcaacaaaca tggattgatc acctactatg tgccaggcac tgtgctagat gccagagtaa 20160
gcccatgttg gcttgctgcc tgctgcatcc ctatctctta gcacaatgag gcaacagtta 20220
tccatcaatg tttattgaat taatgaacat gctgtctgcc ctcagggatc tgaggattca 20280
ttattcttac aaaatctgac gttgaataca gtataaaatt tgttgctctt catgttagaa 20340
atattaatta ttcagaactt ggaattctgt taggaaattt agagaaacaa gataatcttg 20400
gttttatgtg ccccaagttt tctgtatatc aaatgaccct tttaaatttt gtgaaaatga 20460
aagaagccaa tgtttactga agatctagta cgtatcagtt acttttgcac acatcctata 20520
catcctatga tttaagcatc aacaaaacct atgaggtgta gatagtatta tctgtgttta 20580
attgagcaag cagctaagaa ctggagaagt gactaaccta aggcatcaca gatagaaaat 20640
tgtggaactg ggacttaaat tcagcctagg ctgtgtctgt tgcactgccg cttattacat 20700
taaatgatcc taggatatgt taagcaaagc caaactctga agtattgtac tagtgatacg 20760
gctccgatga ctggaggaac actggggttc ttggtctcat gccggtttgg ataaaatgac 20820
atggacacac gtggagtggt tttagggagg gaaaagttta ataggcagga aagcaggaag 20880
gaagaagaaa acagctcccc ggtacgggga gagaagtagg gggattcaaa caaagagaaa 20940
acctcatgtg cggcagaaaa gtggctgctt atatgaggat gcaggaggag gtggtgtctg 21000
atttgcatag ggctcagggg attggtttga ccagtcatgt cattcctgca gcctgtgaaa 21060
aaactgaccc tcccacccta gctttttaat atgcaaatgc agggcgccat tatgttttac 21120
acacatgggg acatgtgggg gtggccatgt tgccaggcac atgtaggggc aagggcaaga 21180
agatggcagg aatcaccatg tttggatgga cccagtttct aatggctggc atttgcatat 21240
caaagcttgc tggcccagct cagagccggg gctttcctgc tagacaagaa acgtttctgg 21300
agctgcttta aaagaaataa aaactcccca aggacccctt ttcctctcta tctgcctaaa 21360
ataatttatt aataactcct gtaacactag gatggaggga tgaattggtc caggggtctt 21420
ggtgtgtgcc ctgcattcag ttgacctact gtttacaata cacctactgt ttacaacact 21480
attttctaga tcttgtgggg aacccaaacc aagggccagt ctggctcacc tataattcca 21540
ccaagcagcc agaaaagtat aaacgctcta cagcaaaggg ataaatcaag gtttagtaga 21600
agaaaagctt tataagtaat gtggaactaa aaggttgaat atagttttca ataatgttga 21660
gcataaatgt tctccagatt gtggaaagat cactaactgt tggctgggaa gggtaggaga 21720
ggagagagtt tgaaacacag agaataggaa ggagtggtga tgtagtccaa taactcaccc 21780
agaacccatg gacgtgaaag ctttgtttgc tctcagatcc ataactagac taaaggagtg 21840
aatcagatct gctcccctgc accccaccct gctcaccttc cacacctgcc aagggccacc 21900
cagcaattcc attctgcttg tcaaatcccc taaggaggat atgtctggaa cagccaccac 21960
tcctccccct gctcttccct ctggtatgtc aggattccct gcacaaccgt gctccagggt 22020
ccttgggatg attattcaga aaccagagaa gtatgtagaa aacttaatcg gaggcactta 22080
aaggctttaa aagggaattt taaaaaccat ctttccctct tttataaggc agtctgagta 22140
tttaagaagc aaattaattg agtccacttt acagtgttgg ggcaaaagca tgcaagttcc 22200
aacatttaca cactaacaga aaattctttt cccttccact gtgctccttt tctttcttgg 22260
gcctgctcca caaacttcta accacagtcc taaattggta ccccatgacc ctgtgtgctt 22320
cgattgccta cactggtttc agacccacgc tgtggattca aatcaaacct gcctttctcc 22380
ctgttactat gtccacccag caccctcctt gcacacacag tctttctctt ctttcctcca 22440
tgtgcagacc tttaccacag ctgtcccaaa tgtgtgaaag gccaaccata actcttcctt 22500
taaaggtcct ttagagcagt atggaaagag tgctgaactt ggaagaccta gattctcttt 22560
ctatactcat tatgtgatcc tgagcccctc acttaacctt gcagggcact tacaaaataa 22620
agagatggag ttcatgatat cttaaggtca ttttccatgt ccaacattct ctgactcttc 22680
atctttccct gactcaacat tctgttccta tatagtcaac accttcccac cttaatctca 22740
tgctcatgcc ctcttagaaa gtctttacaa ctgttgaggg tgcagtggct catgcctgta 22800
atcccagtac tttgggaggc cagagtgggc agattgcttg agctcaggag tttgggacca 22860
gcctgcataa catggtgaaa ccccgtcttt attaaaaata caaaaaaaaa aaaaaaaaag 22920
ccagatgtgg tggtgcttgc ctgtggtccc agctactcag gaggctgaaa tgggaggatc 22980
acttgaaccc aggaggcaga ggttgcagtg agctgagatc atgtcattgc attccagcct 23040
gggtgacaga gagacaccct gtctcaattt aaaaagaaaa aaaagaaaga aagcggcggg 23100
ccgcggtggc ttacacctgc aatcccagca ctttgggagg ccgaggcagg tggatcatct 23160
gaggtcaggg gttcgagacc agcctggcca gcattaagaa actctgtctc tattaaaaat 23220
acaaaaatta gctgggcatg gtggtgggca cctataattc cagctactca ggaggctgag 23280
gaaggagaat cgcttgaacc cgggaggtgg aggttgcagt gagttgagat cgtactattg 23340
cactccagcc tgggcaagaa gagtgaaact ccatctcaaa aaaaaaaaaa aaaaagaaaa 23400
tatttgcatc tgtgaactgt cttctgtgtt gaggatgttt gtggcagaag gagatagacg 23460
taggctctgt ctacgtctgc ctggtgcctc cacaaggagc agtgtatgct cagagaatag 23520
aagtgaattt tactattagt ataggtgacc catattgaaa atgtttgtaa atctgctacc 23580
agaacaacac agtcattcaa agacaattaa aaatgcattt tatacttcct gctatttata 23640
attattcatg gatctgctgc ctacagtcag gtagtaaaag gagagccaga aggaatcata 23700
gtgaacatct catacaatgc tatctttgtt gttggtttga acataagcat ttttgcgtga 23760
atttgcgtgt aggtctcttt tatttctctt attgcataac ctgaggctga aatacttcaa 23820
gtaatgtatc tatttgctca tattgggtag aaacatccct attattccaa ttttcccttc 23880
tcctgcttaa aacatatagt gaaatgaaag atgcagagat aaggaaatca gggaaaagaa 23940
aaatagtcat aggatactaa aatgagccac agatacctga aactgcatag ttgctataaa 24000
tgagccataa atttgattct gagctttcca gtggccccaa aaagataaac ataatagtat 24060
ttattccatg acataaaaat gtatttgtat ttctctgtgt tcaagaggaa gagaaatttg 24120
tactatgggt cctcatgaag gagccactaa gtcagtgttg tagaccacac attcaacgat 24180
atcgtattaa tacccatgat gatgaattca ttcattcaat aagcatttat tgagtactta 24240
ctttgtgctg tatatgtttc agtgtattgc agtaattatt ctttttgatg ctcaaattgt 24300
cctattgtgg gtcagtagga gcccgttgat tcatgtcctt ttgacattat tctgtagttt 24360
ttgatacttt ttttcctagc atgatgagat gttccaggct tatgtcgtat atttcttgtt 24420
ccgtaactca aattgaccat tttgttaatg aaacttgatt tttttcagtg aaaagtggtt 24480
ttatagaaca caatctgggc acttgaagtg tttattgtta ctgggttgtc attacttaca 24540
agactcagtt aacaaattag gaaaaagatt gatttagaaa gaaaataaat cctgagttca 24600
tattgttatt tccaatttaa agattaaagg gttttcgtat aacttatttt atatgtgtat 24660
gtcttttctc ttactttgaa atcttggttt ccaataacat gaacataatt acttccttta 24720
tcctaatagg tacgtatatg tgtatatgtc tatgtatgta tgtatgtagg tatgtatgtg 24780
tgtatgtttc tatctgtaaa acaggaaaaa tacccaccta atggagctta agatttcttt 24840
atgagtattt tttgtcctta gggtatttaa tcaaattact gttacttaaa ataatgtttc 24900
tctatgtggt tatgccatca acttcatata caattatttt atttcaattt gtcttcgatt 24960
tttaaggatg gttttcttct tctgatttaa ttttgttttt aaattatgta aaatattttc 25020
ttggtttcag agtcaaatct atgaacattg agaggtctat tttgcctctc tgtcccctcc 25080
cccttattat tttactcccc ttatagataa tgcttttatt tttccattac tttttttttt 25140
tttttttgga gacaggagtc tcgttctgtc acccaggcag gagtacggta gtgtgatctc 25200
ggctcactgt aacctccacc tcccaggttc aagcaattat cctgcctcag cctcctaagt 25260
agctgggact acagacactg accaccatgc ctggctaatt tttgtatttt tagtagagac 25320
agggtttcac tgtgttgatc aggctggtct caaactcctg acctcaagtg atccgcctgc 25380
cttggcctcc caaagtgccg ggattacagg tgtgagccac cgtgcccagc ctctattact 25440
ttttgaaaat aagccaatga cctatatgta tcctatctcc tttcttacac aaaaggtagc 25500
aggccagagt tcaagattac agtgagctgt catcatgcca ctgcacttta gcctgggcaa 25560
cagagtgaga ccttatctct aaagaaaaac aaacaataaa aaattttaaa aataatttct 25620
atgaattaaa aataatttta aacacaactg catatgaaga caacaaagga aaactctcag 25680
gaaacactga aatatgaaaa tcaagtgaga ttagagcaaa taaggatgtg tatgggaagg 25740
ttctgtagaa gacagattga ggcccaaaca gagagagctc taaatacatc atgaaggtta 25800
ccagaaatgt gagaaattcc tgaagaagag ggaagaagca aatcctctcc aaatttagtt 25860
cacttagttg ataatcatta gttgattccc agtagagtca gtcttttatc atcagtgcca 25920
ccactgttgt tctctgcatt aacaaaggag atattaatct ggaaagctgc aatcattttc 25980
actgtagaat cagcctttta ttttttaggg ttttttaatt tttttttttt aggacacctt 26040
catttaagat cacttcatat ctcctctggc ttttgcaaat gctctttggc tgatctactg 26100
tttccaccac tgtcctcaac attttttagt atattattta atttatgtat gtattggtgt 26160
ccactgatta ttgtttgcct tcccccattg gaacacagat tctataaaag tagggatctt 26220
tattttgttt accactgtat tccaggtgcc tagaacagtt cctttcacat tgttggtgct 26280
caaaaagaaa aaagttaaat gaatgaatat cagcagcaag agcattttga ggagaaagca 26340
aaggtgtaac tgtgggggtc tccattaatg tatgtatatc atcctcttat acatttgtcc 26400
catcacccgc tagccctgga actctcatta tttttttttc tggtaatgca ggctccaact 26460
caactggcaa tgagaatatg aactgaggca actgtatttg aaaaatgaaa gaatataggt 26520
gatatgggtt taaagaattc agtatttgtg tatttttcca ataagtacat gcttatgagc 26580
atagccttac aaaataacaa aaataatttt ttacatttac tcacacactt accatttcca 26640
gcactcttca ttcctttgta tagatccaaa tttgtatctg gcatcatttt acttctgcct 26700
aaagaactaa ctctaacatt tttttatagt gcatgtctct cagattttct ttgtctgaaa 26760
attactttat tttaactcca tttctgaaat acattttcag tgggtattgt attctgggct 26820
gacttttttt ttttttccca gtgcttgaga gatgccattc cattctcttg tggctttcat 26880
tatttttgat gaaaaatcag ttgtaagtct tactcttgtt cctctgtaca taatctgact 26940
gctgcttcta aaattttatc tttattgctg gtttttagca atttctgtgc cttgttttgt 27000
ttttgttatt tagtgtttgt tctgcttggg attggttgag cttggatctg taggtttata 27060
cttttcatca aatacgaaaa attttggtca ttatttttca aatatttttt ctactcctcc 27120
ctcctcactt tttccccctc aaacagcagt tacatgtatg tcagacaact tgctattatt 27180
ctataagtca ttgagacaat gttcattctt ttttattttt aatttttgtg ggtaaatagg 27240
tgaatatatt taggggttca tgagatgttt tgatataggc atgcaatgta aaataagcac 27300
atcatggaga atggggtatc tattccctta agcatttatt ctttgaatta aaaacaatcc 27360
acttacactc ttatcacttc tcagcctttt gggataagat catgtgtaaa aacaatgtac 27420
ttacactttt cattttaaaa tgtacaatta agttattatt gactatagtc accctgttgt 27480
actatcaaat agtaagtctt actcattcta actaattttt tataaacttt aactataccc 27540
acttctcctc ccacctccca ctccctttcc aacctatggt aaccatcctt ctatactctg 27600
ttcatgagtt cacttgtttt gatttttaga tcccacaaat aaataagaag atgtgatgtt 27660
tgtctttctg tgcttggctt atttcactta acgtaatgat ctccagtgcc atccatgttg 27720
ttgctaatta ctggacctaa ttcttataca tggatgaata gtacatcatt gtgtagatgt 27780
accacatttt ctttattcat tcatctgttg atggagactt agattgcttc caaatcttag 27840
ctatagtaag caatgctgca acaaacagga gtgcagacat ctctttaata tactgctttt 27900
ctttcttttg ggtatatatc cagcgatggg attgccagat catacagtag ctcaattttt 27960
agttttttga ggaacctcca aactgttctc cataatggtt gcactaatgt acattcccac 28020
caacagtgta caagggtccc tttttctcca catcctcacc agcatttgtt attgcctgtc 28080
ttttggatat aagccatttt aactggggtg agaagatatt ttagttttca tctgcatttc 28140
tctgatgata aatgacattg agcatctttt catatacctg tttgccattt gtctgtcttt 28200
gttggaaaaa tttctgttag ctcttttgcc cattttttta atcggattat taaatttttt 28260
cctatagagt tgtttgagct ccttatatag tctggtgatt aatcctttgt cagatgggta 28320
gttggcaaat attttctgtc attctgtgag ttgtctcttg actttgttga ttgtatcctt 28380
tgatgtacag aggctttgta acttgatgtg atcctatttt tccatttttg ctttggtcgc 28440
ctgtgcttgt ggcatattgc tcaagaaatg tttgcccaga ccaatgtcta gagactttct 28500
gcaatgtttt cctgtagtat tttcatagtt tgaggtctta gatttaagtc tttaatccat 28560
tttcatttga tttttgtata tggtgagaga tgggtgtcca gtttcattct tatgcatgtg 28620
gatatccagt tttcccagta ccatttattg aagagaccct ctctttccca gtgtatgttc 28680
ttggcacctt tgccaaaaat gagttcactg tagtttctgg gttctctctt ctgttctatt 28740
ggtctgagtc tgtttttatg ccagtactat tctgttttag ttacaatcat tctgtagcat 28800
aatttgaagt caggtaatgt gattcctcca gttttgttct tttcactcag gataccttta 28860
actattctgg gtcttttgtg gttccacata aattttagga ttgtattttc tatttctgtg 28920
aagaatgtca ctggtatttt gatagggatt gcattgaatc tgtagattgc tttgggtagt 28980
atggacattt taacaacatt gattcttcta atccatgtat atgggatatt tttccatttt 29040
tggtgtcttc ttcaattttt ataatctgtg ttttatagtt ttcattatac agatctttca 29100
cttctttggt caggttaatt cctagatatt taattttatg tgtggctatt ataaatagga 29160
ttacattttt atttcttttt cacatagttc actgttggca tatagaaatg ctactgattt 29220
tttataaact tttatgttat gttcaggtgt ataggtacag gtttgttata taggtaaact 29280
catgtcatgg ggtttgtcgt acagattatt tcatcaccca ggtactaagc tagtacccat 29340
tagttatttt ttctgatcct ctccctcttc ccactcttca ccctcagtag gccccagtgt 29400
ctgttgttcc cctctgtgtg tccatgtgtt ctaatcattt agatcccact tgtaagtgag 29460
aacatgcagt atttggtttt ctgttcctgt gttacttttc taaggataat ggcctccatc 29520
tccatccatg ttcctgcaaa ggatataatc tcattctttt tatggctgca tagtattcca 29580
tgatgtatat gtaccacatt ttcttttttt ttcccttcaa cttttatttt aagttcaaga 29640
gtacatgtat gtacaagatg tgcaagtttg ttacataggt aaatgtgtgc catggtagtt 29700
tactgcacag atcatcacat cgcctaggta ttaaggccag catccattag ctattcttcc 29760
tgatgctctc cctccctcac cacaccccct ccgacaagcc ccagtgtatg ttgttgcccc 29820
ctcacatgtg tccatatgtt ctcatcattc agctcccact tataagtgag aacatgtagt 29880
gtttgggttt ctgttcctgc attagtttgc tgaggataat ggcttccagc tccattcatg 29940
tccctgcaag gaacatgatc tcattccttt ttatggctgc atagtattcc atggtgtata 30000
tgtaacacat tttctttatc tagtatatca ttgatgagca tttaggttga ttccatgtct 30060
ttgctattgt taatagtgct gcagtgaaca tatgtgtgca tgtatctttg taacagaatg 30120
atttatattc ctttggatat agacccagta atgggattgc tgggtcaaat ggtatttctg 30180
cttctaggtc tttgaggaat tgccacacta tcttccacaa tgattgaact aattcatact 30240
cacaccaata attccttttt ctccacaaca ttggcagctt ctgttgtttt ttttgacttt 30300
ttaataatag ccattctgac tggcatgaga tggtatctca ttgtggtttt gatttgcatt 30360
tctctaatga tcagtgatgt tgagcttttt ttttcatatg tttgttggcc agatgtatat 30420
cttcttttga gaagtgtctg ttcatgtcct ttgcccactt tttaatggtg ttgtttgttt 30480
ttcttgtaaa ttggcttaag ttccttgtag actctggtta ttaaaccttt gtcagataga 30540
tagattgcag aaatttttct cccattcttt aggttgtctg tttgctctaa taatagtttc 30600
ttttgctgtg cacaagctct taagtttaat tagattccat ttgtcatttt tgctttcatt 30660
gcaatcactt tcggcatttt tgtcatgaaa tcttttcctg tgcttatgtc ctgaatggtt 30720
ttgcctagac tttcttctag agtttttttt tatagttttg ggttttacat ttaagtcttt 30780
aatccatctc cagttaattt ttgtatgtgg tgtaaggaag gggtccagta ttaattttct 30840
gcatttggct agccagttcc cctagcgcca tttgttaaat agggaatcct ttccctattg 30900
cttgtttttg tcaagcttgt caacagtcag atggtggtag gtatgtggtc tgatttctga 30960
gctattttgt ttcattggtt tatgtgtctg cttctctaca actaccatgc tatttgggtt 31020
actgtagcct tgtactatag tttgaagttg ggtagtgtga tgcctcaagc tttgttcttt 31080
ttgcttaata ttgccttggc tattagggct cttttttggt tccatatgaa ttttaaaatg 31140
attttcttct aattctgtga agaatgtcaa tggtaattta atgggaatag cattgaatct 31200
ataaattact ttgggcaata tggccatttt catgatattg attcttccta tccatgagga 31260
tgaaatgttt ttccgtttgt ttgtgtcttc tctgatttct ttgagcagtg gtttgtagtt 31320
ctccttgaag aggtccttca cttcccttat tagctgtatt cctaggtatt ttattctttt 31380
tgtagcaatt acgaatggga gttcattcac aatttggctc tctgcttgcc tgttgttggt 31440
gtataggaat gctagcaatt tttgcacatt gatgtttata tccttagtct ttgctgaagt 31500
tgcttatcag cttaagaagc ttttgggctg agacaatggg gttttctaga tataggatcg 31560
tgtcatctgc aaacaaagat aatttgactt cttctcttcc tatttgaata ccatttattt 31620
ctttctcttg cctgattgcc ctggccagaa cttctaatac tatgttggat agaaatagtg 31680
agatagggca tccttgtctt gtgccagttt tcaagggaat gcttccaact tttgcccatt 31740
cagtatgata ctggctgtgg gactgtcata gatggctctt attattttga agtatgttcc 31800
ttcaatacct agtttattga gagcttttaa catgaaggga tgttgaattt tatcgaaggc 31860
cttttctggg cctattgaga taatcatgtg gtttttgtct tttattctgt ttatgtgatg 31920
aatcacattt attgatttgc atatgttgaa ccaaacttga atctcaggga tgaagccaac 31980
ttgatcgtag tggatacgct ttttgatgtg ctgctggatt tggtttgcca gtattttatt 32040
gaggattttt gcctcaatgt tcatcaagga tattggcctg aaattttctt tttttgttgt 32100
tgtatctctg ccaggtttgg tatgaggatg atactggcct caagaatgag ttagggagaa 32160
gtccttcctt ttcaattttt tggaaaagtt tcagtagaaa tggtaccagc ttttctttgt 32220
accgctggta gaattcagct gtgaatctgt ctgatcttgg gctttttttg gttgttaggc 32280
tatttgttac tgcctcaatt tcagaacgtg tcattggtgt attcagggat tcaatttctt 32340
tctgcttcag tcttgagaag gtgtatgtgt ccaggaattt atccatttct tctagattct 32400
ctagtttatg tgcatacagg tgtgtgtagt attctctgat ggttgtttgt atttctgtgg 32460
gatcagtgat gatatcccac ttaacatttc tgattgtgtc tgtttgattc ttctctcttt 32520
tgttctttat tagtctagtt agttgcctat ctttttatta attttaaata aaacagctcc 32580
tggattcatt gatttttttg aaaggttttt tgtgtctata ttttcatttc aactctgatc 32640
tgatcttggt tatgtcttgt cttcttctag ctttgaaatt tgtttgcttt tggttctgtc 32700
attcttttag ttgtgatatt aggttgttaa cttgagatct ttctagcttt ttgatgtggg 32760
catttagtgc tataaatttt cctcttaaca ctgcttcagc tgcaccccag agattctggt 32820
atgttgtctc tttgttctca ttagtttcaa ggaatttctt gatttctgcc ttaattttgt 32880
tatttaccca ggagtcattc aggagcaggt tgttcaattt ccatgtagtt gtgtggtttt 32940
gagtgaattt cttaatcttg agttctaatt tgattgtgct gtggtcagaa agactgttat 33000
gatttcaata cttttgcctt tgctgaaaaa gtgccatgtg gtgatgagaa gaatgtatat 33060
tctgttgttt ttgggtggag agttctgtag atatctatca ggtcctcttg atccagagct 33120
tagttcaggt cctgaatatc tttgttaatt ttctgtctca gtgatatgtc taatattttc 33180
agtggagtgt caaagtattt cactattatt gtgtgggagt ctaagtctct ttgtaggtct 33240
ctaagaactt gctttatgaa tctgggtgct cctgtattgg gtgcatatat atttaggata 33300
gttagctctg cttgttgaat tgaacgcttt accattatgg aatgcccttc tttgtctttt 33360
ttttatcttt gttggtgtaa agtgtgtttt gtcagaaact aggactgcaa cccttgcttt 33420
tttctgtttt ccatttgctt cataaatttt tctccattcc cttattttga gcctatgtgt 33480
gtctttgcac ttgaggtggg tgtcttgaag acagcatact gatggccctt ggctgtttat 33540
ccagcttgcc attctgtgac ttttaattgg gggcatttag cccatttata tttaaggtta 33600
gtattgttat gtatgaattt gatcctgtca tcatgatgct agctggttat tttgctgact 33660
tgtttttgtg gttgcttcat agtgtcactg gtctgtgtac tttagtatgt ttttgtagta 33720
gctggtaaca gtttttcctt tccatattta gtgcttcctt caggagtgct tgcagggcag 33780
cctggttgtg acaaattccc tcagcatttg cttgtctgaa aaggatctta tttctccttc 33840
acttatgaag cttagtttgg cccgatgtga aattctggat tggaaatatt tttctttaag 33900
aatgttgaat attggtttcc agtctcttct ggcttgtaga gtttctgctg aggagtccac 33960
tgttttctgt tgggcttccc tttgtaggtg acctggactt tctctctggc tacccttagc 34020
attttttttt tcattttcac cttggagaat ctgatgatta tgtatcttgg agttgatctt 34080
cttgtggagt atcttactgg ggttctcggc atttcctgaa tttgaacttt ggcccatctt 34140
gctagcttgg agaagttttc ctgtatgcta tcctgatgca tgttttccaa ctcagttcca 34200
ttctgcccct ctctttcagg taccccagtc aagtcatagg tttggtctct ttacataatc 34260
tcatatttct ctgaggtttt gttcattcct tctcttttta tttgtttctg tattcttgtc 34320
tgcctgtcta tatgcagaaa gatagtgttc aagctctgaa attctttcca ctgcttggtc 34380
catcctatgg atacttgtga ttgcattgtg aagttcttgt gtattacaag aactttattt 34440
ttttatcttt atccagtcta ccattgatgg gcatttaggt tgattctatg tctttgttat 34500
tgtgaataat gctgtaatga acatactaga atgattcatg tttatttggg taaatgtgtg 34560
ttgatttcgt atcctgcagt tttattgaat ttatcagttc taatcatttt tcttgtggag 34620
tctttaggtt tttccaaata taagatcata ttgtctgcaa acaatgatca tttgagttat 34680
tccttttcaa tttggatgct ttttatatct ttctcttatc taattgctct agctaggact 34740
tccagtagta tgttgaataa cagtgatggc agtgggcatc cttgttgtgt tccagatttt 34800
agaggaaagg ctttgtcctt cccctatgcc ccaggtaggt ccaggagtca aggactagag 34860
tccaaaacct tagaagtcta cctggtattc tattatactg tggctgagct ggccctcaga 34920
ccacaagaca cagtccttcc cactcttctc tcccctttcc aaaggcagag gaactgcctt 34980
tagtagagac agggtttcgc catgttggcc actgccaacc cagcccatga ggaggactgc 35040
cagactactg ctgatgttcc cttaaggccc aagttctctt aaatcagctt gtcctgaatg 35100
ttacctagcc tgagactcac ccttcaggac agtgggctcc cctctggccc agggaaggtc 35160
cagaaatgct gcccaagggt caagtcctgt aatcagggac tccaagagcc ctcttggtat 35220
tctaaccccc tgtatctgtg gtggtaccta aggtgcaaga caaagtccct tttacatttc 35280
cttctgcttt tatcaagcag aagttttgtc ctgcagccac cacagctggt aatgtactga 35340
gttctacctg aagccaggaa gtctcagagg ctcacccaag gccctcaaca tagtccctgg 35400
ttattgctgc tggttattca gaaccaaggg ctcttcactt agcaggtgat aaatgccggc 35460
agggctgggt cctttccttc aatgcagtgg gttccctctg gcccagggtg tgtctagtaa 35520
tgtcacctgg tttctagggc ctagaatgga ggcctcatga ctctgaccag tgccctatcc 35580
tgctgtggct gcgctggtat cctagacgca agacaatggt ctccccactt ctccctctcc 35640
tattctcaag tggaaggaag gggtctcttt tggagctgta agctgtgtag cctggggtaa 35700
ggggaggggt gatgccaata ctctcttggc tgccccagct ggtgtctcag taggttgcat 35760
gcactcccag tctgctgtct ctgggcctag ttcagcacca ggactcacct aagagttgca 35820
gtccttatgg cctagactgc ttttgaagtt tacttggaga caaagagcac tgtggccttc 35880
actggtgagg tttacaggca ctcaagttta gaccactggg attggtgatt cttctctggc 35940
tagggctgtt ttaaatcctc cctccgtttg cacatttcag ctgagtttga tctagtttgc 36000
ctttctgctc tgatttctgg ttcttatgaa ggtgtttttt tctgtgtaga cagctgttaa 36060
cttggtgtcc ttgcagaggg aatgatcagt ggagccttct atttcgccat cttgatccgc 36120
cgccatatat cattcttatc aatcattttc tgtttatgca cctgaaaata cactggtata 36180
caaaattaag atccttactt tcacagaatt tgtgttctaa tgggggaagt caataatcgg 36240
tggacaccaa tacatatata aattaaataa cacattaaaa ggtgttgagg acatgctggg 36300
catggtggct catacttgta atcccagcac tttggggggc cgaggcgggt gcatcacttg 36360
agatcaggag tttgagacaa gcctggccaa catggtgaaa ccctgtctct actaaaaata 36420
caaaaattag ctgggtatgg tggcaggtgc ctgtaattcc agctactagg gaggctgagg 36480
caggggaatc gcttgaagct gggaggcaga ggttgcagtg agctgagatc ctgccactac 36540
actccagcct ggacaacaga gtgagactct gtctcaaaaa aaaaaaataa ataaaaataa 36600
aagctgttga ggacaatgga ggaaaaggca gatcagagaa agaacattta caaaagccag 36660
agggagtgtg aagcaatttt aaatgaggtc agatttttgg ataatttcta ttgctatgtt 36720
tttaagttaa ccaatgtttc tttttgcaat gtctgatctg ttacattttt atttcagata 36780
ttatattgtt atctctagaa gttctattta gatctccttt ttatctttca attctctcct 36840
cattttgttc atattttgct ttatatccta gagcatattt ataatagttg ttttaaggtt 36900
cttgtgtgat agttatatca tttctgttat ttctgtgtct gatattattt atctattttt 36960
taaaacttta tgggtatagg tcatattttt tcatttcttt gaatgcctgg tgattatttt 37020
gaattttaca ttgttgagca ctggatgttg ttatattcct tttaagagca ttgagttgtg 37080
ttctggaatg cagttgagtt tttacagatc actttgatcc atttgagact ttcctttagg 37140
gtatatccag agtaacatct agtttagagt taatttgttt ttactactaa gatgtggctt 37200
ttctgaggat tttatccaat gtcctgtgta ttttggggtc tctccacact ggctgatgga 37260
aacacagggt agtctcagcc ctgtgtgagc tccaggaatt actcagctat tgcctatcag 37320
tgtttttttc ttcaactcca agtagtttct tccagctcat atccaaatca tacttaggag 37380
aagactgggg gggatcctct gcagatttcc aaagtgctct ccccactctc tgtatctccc 37440
tcttcttcat tactctgtcc cacaaattct aaccacctca acatccttaa attccaatcc 37500
attccccctt acctcaggta gaattctagg ttctgattgg ttttccctcc acgtgctgtg 37560
acctggaaat gacctccagg cagtatctct taggaagccc agttgtgtgg catctgttgt 37620
acaatgcctg aaaatgattc tttcatgtgt tttgtctggt tttcaacttg ttcacagaaa 37680
aaagcaattt gcacagcagt taattcttca cagacagaag cagaagttct accaactgca 37740
aaacaaccaa aacaacttgt taaaagacag tatttgtatg actggtcata aattacgtat 37800
agaagaatag agattttgtg agaaagatat gggcctgtac agaggggtga acttgcaaat 37860
gaccatcttg cttggggata gtgtctgttt tcctgatcct aatcactggg aaggattctg 37920
taatctctgt caaataaatt gcaaacacta ccacacatgg ccttgggtct actactgtct 37980
atgacataaa cagtttctcc ctagagactt agttgtgagg gtacaggggg aaggtagctt 38040
ttggaggggc ctggaagacc cttccctttg tgccttcgat tctgtatata tcttgtggtc 38100
agaagtctta ccattaccct ctctgataac tccccaccca ctttcccaat cactaaacac 38160
tttttgaaac cattcaactc tttcctttca atgattgagc ccttcattgt ttcatcagct 38220
cctcttgtgt gaatctctct gaatgtgtgc caagtttgca gtttaatgcc tgtcccatgt 38280
aggagcccaa tatcacggta tataaagttt ctacactgga tatccatgga ctgaagaggg 38340
gcctagcatt cagggttcca agccagtgag tttagcttat ccaagggtac ctctagaatg 38400
tgctcagaaa tttattccaa gtcagagttg catcccccag gactttaggc tcagatggac 38460
aaccccatca tatttacaga atccctcaaa gataatttaa gtttaagatt gtcagcccac 38520
ctggggtgca cagtgttgac cagggtttct taaccttagc actgttgaca tttggggcca 38580
gataattctt tgttgttcag accatcctgt gaattatagt atgtttagca gcatccttgg 38640
catctaccta ctagatgtga atagcatcct tctcttaatt ttgacaacca cagatgtctc 38700
cagaattgcc aaatgtcccc taaaggtgca aaattgcata gttgagaact actggtaaag 38760
aggcactatg gcatgccaag ctctagggag cccacagaag tgcacctctg ggaactaaag 38820
ctgaagaaac ccaagaggcc ccttggtatc ttcttggaag aagttagtcc agagtgtctg 38880
caccatgtgg agtgtatact gggatgacat tgaccttgga atgtaaactc ctgggattct 38940
tgcctctgca gatttggagc agggttttct tcttctctgc ttttcagttt acttatttga 39000
aaatgaggaa tggtgtttac atcacaaaac actgtagtga ggacaaaatg aggttttatg 39060
tatatataca cccatacata tacatataca cttcttccaa atgatataat aatatataaa 39120
cattgaatga ataatggttc aaatataagt gtacttattt gccactatga ttaaaagggc 39180
aatataggaa aaatacattt tcttctaatc catcatgttg taataatcct ccctgtggtt 39240
gcagtatggt tctgtgctag aaggcacaat aggaaatctc taactttaaa aaaaaagaaa 39300
agaaaaaata tctttctagc aattaaaatc tcaactaaat tagaatgcaa ataggttttt 39360
atatttgctt cttaattttg cattcaataa tctgactaga atatgcaata atttaaatgc 39420
cttgatggga gatagtggct tttagttctc ttgggatttc attgtaataa acctggtaaa 39480
taattcagga acatatgaga ggccaatgaa tggtcagcac ctggtgctat attatttgtg 39540
cctaagcaca cagactccaa agatggcact ctccacctgt cactgttgtt ctggcttaaa 39600
catgggccct gtgttcagtg gctattgaga taatagtaat ggatattttt gccttgtcca 39660
attttcctcc acaatcaaag aaaactgtgc taagctgttt aaaaaataca aagcagaagt 39720
ggcagcctct tttagattac cactggtaaa atttcaaatc tattttctct attaagggat 39780
tgattgtttt aaagaattag ggatatggct atcttttcta ctggtgctaa tttgagcctt 39840
tttgcctttc tgtctttgtt ccacaaggct gagcttctct ttagatcaca ttattcatat 39900
tgcaaggatc ttctgagaga aataacacca tcctctggcc agccactcac tctgcaggag 39960
ttcctagagc tccccagttt ctttccctat tgcctgagta gtctatctca cgcctgttag 40020
tctcacagtt taaatacaaa cacacaaaga ctcttgcagg cagcttgggt acctttcttt 40080
gaccccagcc gactggacat agagaacaag agctagagag aacaagagct agagtgaccg 40140
acagatcatg tgtggagaca gcatggggca cctgagccca gcaccatcca ggatcagaca 40200
gaacttaagc catgagctgc ctagaaagat cttgggaggg cactgggttt cccagtatgg 40260
aaaaaagaaa aatgtggctc acaagtctaa gctaaggtct ttacagtact gggccataaa 40320
caggatctga aaagaaactg cagaaaatgt tagatatgct ttatctttgt tttaaaaata 40380
ttatttacta taatggctta aaatatgttg atttaaatat atgatatttg atacctttgt 40440
aatatatata ataaagtgta taataaaata taactatata attaaaatag atgatatttt 40500
aaaacctctc taataaacca tttacgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 40560
tgtgtgtgtg tatacatgcc tttgtttaac aggtttaatt gctttccttt cttcaggaac 40620
cagagtgagg gtactcgaac agtgactgcc atctggtggt taaccagaat catcaccttg 40680
tgtagcctga tggttactaa gatgtccact cttgactcac atggcatgca ctcgcagcag 40740
gggaccagtt gaaggatgtc tgactttgga gggtcaccag ttgaaggatg tctgatgaag 40800
gagcctagcg aaataaccct ttgcttctac ctgaatgggt tgttcactct ggattctgag 40860
cctgcagcca gctccaaaat ggggcctctg aagaaaagat ttgagttgct cttgtgtctt 40920
agtcaaagat ctacatccct accagtgggt aaccaagact gtgaataagc acacaccaac 40980
aggggcatgt ggtgacatgg agcctgaaat aaactgctct gaattgtgtg acagttttcc 41040
tggccaggag ctggatcgga gaccccttca tgatctctgc aagacaacaa ttgtaagtga 41100
gcagccacag gatgccaggg ctgctcagat gtatgtggtg gtggtggtgt tggggaggag 41160
gaggtggagg gaaaggggga tgaggaaggg gaggagtggg aggagaaact gctcatgcag 41220
gatacatatt tcccagcact tggtgacgat ggggcagttt gtttttgacc tatagaagat 41280
ccttcattcc taacagctcc tccttattct gtcctcagac atcttcccac cacagcagta 41340
agaccatctc ttcattatct cctgtcctct tgggtattgt ttggactttt ctcagctgtg 41400
gacttctgct gatacttttc tttcttgcct ttacaattca ctgcaggaag aacaggtaag 41460
cagcccagtt tctcatcaca catagctcaa tcatgaaatc ccaaatgtta gtatcttttg 41520
gcagcacaag ccactatctg gtctcccact acaggattaa accacatgag acattccctc 41580
tgaaatagtc tacctgttga gaaggggaaa gatctaggtc ggtattgtgc taactactgc 41640
aagggtatcc aaagaagaga atgaagagtc tctctctata atggaggtac aatccttctg 41700
agaagatgag gtatctgtat ttaaaatgaa gaccatgtag aggattccaa aacaacacaa 41760
aaacttgagg acagcacagc agaaccagtc tgggtgagtt agggtttctg caaaagcagt 41820
gaagcactgc tacctggcta tttgctagat aattctggct gactagaaag tcatcagctt 41880
atcagggtaa gtatggctcc caggattcgc aaaagaagca aaatggtgac ttttttctga 41940
agggacttat agcaccttgc cttggatgca atttcatcct tcctcagggc ccatcccatc 42000
tctcccaccc ccacactgta ccctcatcct accacagccg tcccagggtg cctcatgaga 42060
agccctgctc cagccctctc cttagcccac agctgacttc tagatggagc ccacaatcag 42120
aaattaacaa cttcctcaaa ccagccaaac tcgtccagcc ccactccagc cttaccctgt 42180
gtggtgacca agcatgtcgt gctccattgc ctgtggattt gacactcaga tgagaattgg 42240
tcagttgcat tttgggatgc tgttttgcca tgttaggcat ggaggacgtg gaattgttaa 42300
gcagcagtga ttggttgttg ggtcagcctc agcatggtgg tgatacgtgg cactccaact 42360
agagtatacc ccagagactg cctcagccac ttttcattct gttcctcaag cacactacgc 42420
tgactcccat ctcaaggctt ttgtacttac tgttcctgta ctgttccctc tgcctggaag 42480
tcctcctcag atattcccat gactagttcc ttctcatctt ataggtcttg gctccagtgt 42540
cacctcttca gagacacctt ccctgatcat cctatctaaa gtagtatccc tacccatgat 42600
caccccctca tctcattcca tatcctatca gcctgtttta tgttccttat agcaagcata 42660
gtctgctatt accatatttg ttgatttacc tgttgattgt ctgtatcccc taccagaatg 42720
gaattctgtg aacacaggga ctttgcctgt cctcttgtgc ccaccactgt gtctccagca 42780
tttagaacag actctgggat ataataggtg ctcagtaaat atgcatccag tgatcctggg 42840
aggaaagaga tttaaatccc aacggtggct gctgccaaca aagtgactgg gaaaatcatg 42900
catttcaagg ttagagaact atggagtaca gtcttttcag ctgtaacatg tttctataat 42960
gcaaagtaat actcaattgg tattacccag ttggtaataa gaaaattatg tcattgattc 43020
atatgttact tttcccccag caaatcaata atttaaacat tcaggggcaa gctttctcac 43080
agctagtaaa ggaagcttta agcttggcag ttccttccct tggtgcaagt agtgtctggc 43140
ttaatggctt aagaacttgt gtcttcccta caagatgagg ctgtaggagt agatgaagaa 43200
gtggagaaga catttgcctt atgtttaaaa acttcagttg attgttaaag aaagcacaga 43260
tccagagcag atttttaatt ttttgacaat gttatctact ggagatgaat gcccctgagg 43320
acctgtgtct tgagatttaa gactgtagaa gttgactttg atcctgggta caaatgctag 43380
tggacattta ctgggtggta gtgttttagt tggaataatt aatattttat taatactctt 43440
gttacaaagt taactgtttt gagtgttatg accccatcct attttcccca cagtctatta 43500
tttttacata taattttgca gaatacaagg tttatcaagt atttatatat cctgttaaaa 43560
caggaacacc tgtaaacagc attatactag aaacccttat atttctttca ctctattaaa 43620
tattttgctg cctgttttgt ttgcagtggg agcatgactt ggcataaaga ataaaatatt 43680
aagaggtatt gtgaataaaa acacatttta caattaagtg gcttacaagg tcagacaagg 43740
aaagataaaa taacccagtt tcaaaagtgt tttattgaac aatacatttg ttaaaagatg 43800
cagcatcaca atcagatgct ttatttcgtt acaattctgt ggtctctaaa tttgggactg 43860
tgtgtgtgag tattcatgtg tgtgtatatg caagaaagga gaggaagaaa aatattttaa 43920
cacaataaaa ataatacaaa aatgtttaaa tccagttgca gatattgaat ttttataaaa 43980
atttcaaaaa ccagtaaaga taaagaaaac ttgaacacta tcaaccaact tgacccaatt 44040
gacatttata ttacctttca cccaacaaca gcagaataca tattcttttg aagtacacat 44100
ggaacattta ccaagatata tcatattctg ggccatagaa aaagtctcat taaatttaaa 44160
agggttcaag ccgggtgcag tggctcatgc ctgtgatccc agcactttgg gaagctgagg 44220
cggatagatc accagaggtc agcagtttga gaccagcctg gccaacatgg tgaaaaccca 44280
tctctactaa aaatacaaaa attagatggg tgtggtggca tgcacctgta gtcccagcta 44340
cttgggaggc tgaggcagga gaacccggga ggcagaggtt gcagtgagct gagatcatgc 44400
cactgcactc cagcctgggt aacagagcaa gactctgtct caaaaaaaaa aaaaattaaa 44460
ggattcaagt catataaact atgttttctg acaatgaaat taaaatggaa atcaataaca 44520
gaaagatctc tggaaaatcc tgaaatattt agaaactaca tagaacactt taatccatgg 44580
tcaaaaaaga aatcaaaagg aaaactagaa aatattgacc agaattaaaa tgaaaataca 44640
acctagattt gttggatgcc actaaagcag tattaggggg aaatctagag aactaaaccc 44700
catattagaa aagaagaaat gtctcaaatc catgacctca tcttccacct tacaaacaga 44760
aaaaaagagc aaatgagacc caaagtaagt agaagaaagg aaataataaa gatcaggtta 44820
gaaaataaaa taggaaacag aaaacaatag gaaaaaaaag tcagtaaagc caaaagctat 44880
gaagataagt aaaactgatc aacctctagc caaagtgatc agaaaaaaaa gaaataagat 44940
acaattaccc aaataaggaa tgggagaggt gacatcacta tagattctgt agatatgacg 45000
gataaggtaa tgttgtaaac aactatggta gatagcctct aagatgttct tcgatgattc 45060
ccacctcctt gtagtcacac tcctatgaag tcctctctcc ttgagtatga ggtgaactta 45120
ctaacttgct ttttagtgag atgtcgcttt tggcattagt tcacaaaaac tgtggcttcc 45180
accttagagc tctctcattg tcccactaac tcccactctg tgggaggcca gctgttgtgt 45240
tataagctgt cctgtaaaga ggcccccatt ggcaaggaac tgatgtttcc agcctgcagc 45300
cagcaagtac ctggggcttg ctaacagcca tgtcagtgaa ctttgaaaca ggtgacacct 45360
tgactgtatt gttgtgacac cttgactgta ttcttatgtg aaaacctgag ccacaggcac 45420
ccaactaagc tgtgacttag aaatattacc agttcaactt caaactcttc taaaaaaact 45480
gaaaataaag aagtaattcc caactcattc tatgagggca gtattaccct gatttcaaaa 45540
ttgaatagga aaaagaagaa ggagaaggag aagaaggaga aggagaagga agaggaggag 45600
gagaaggaga aggaggagga ggaggaggag gagaagaagg agaaggagaa gaagaagaag 45660
aagaggaaga ggaagaggag gaagaagaag aagaagaagg gaggaggaaa gctataggct 45720
aatatgtcct ataaacatag attcaaaatt ttaaacaaaa ttttaacaaa ttgagtatca 45780
ccaaatgtta aaaagagaat acatcattgt gacaacgtga ggtttatccc tggaatgtaa 45840
gctttgttta atatctaaag attgatcaat aactcatgac atttaccaac taaaaaagaa 45900
aactatatga tcatctcagt agatacagaa aaatttttga caaacttcaa catcaatttc 45960
tgataaagtc tcaacaaaca gcatagaaca gaacttcctc cccattgcgc agcacagctg 46020
ctgtggcaga ttgtggccag actgcttctt taagtgggac cccgatccat cccccctcac 46080
tgggcaggac ctccttgtga gaatttcagc aactccagcc agggttttat ggacagaact 46140
ctgatctctc tgggacagag cccctcaggg gaagggtggc cacagtctct gtggttcagc 46200
caacttagcc tttcctgcct gctggctctg gagagtctgg gcagtctgga caaaagggga 46260
tccccccagt gcagtgcacc cagtccccca aggggcagcc agactgcttc ttgaggcagg 46320
tccctgatcc cattcctcct gactgggtga gaactcccaa agggatcccc agacacctct 46380
tacaggagtg tttgggccag cgtcagtttg gagcaggcag ccatctttgc tgttttgcac 46440
cctttgctgg tgatagtgat acctccaggt gcagaaggga cccaggtgat tagggtctgg 46500
ggtggaccac tagcaaacca cagcagccct gcagaagagg agcctgactg ttaaaagaaa 46560
aacaaagcag caacaacaac ataaacaaaa aagatcccca aaaaaaccca ttgaaaggtc 46620
agcaacctca aagactgaag gtagataagc ccacaaagat aagaaagaat caatgcaaaa 46680
atgctgaaaa ctcaaaaagc cagagtgcct cttctccaaa tgattgtaat acctctccag 46740
caagggcaca gaactgggct gagactgaga tggctgaatt gacagaagta gccttcagaa 46800
tgagggtaat aacgaacttt gctgagctaa aggaacatgt tctaacccaa tgcaaagaag 46860
ctaagaatca tgataaaaca ttacaggagc tgataaccag aatagccagt ttagagagga 46920
acataaaaca cctaatggag ctgagaatca caacgtgaga acgtcacaat ccaatcacta 46980
gtgtctatag ctgagtagac caagcagcag aaagaatctc agagcttgaa aactgtcttt 47040
ctgaaataag acaggcagac aagaatagag aaaaaagaat gaaaacaaac aaaacctcca 47100
agaaatatgg gattacgtaa aaagaccaaa cctacaactg attggagtac ctgaaagaga 47160
tggggagaat ggaaccaaat tggaaaacat acttcataat gtcatccagg agaacctcgc 47220
caatctagca agacaggcca acattcaaat tcaggaaatg tggagaaccc cagtaagata 47280
ctccacaaga agatcaaccc caaaacacat aatcatcaga ttacccaagg tcaaaatgaa 47340
agaaaaaatg ttaagggcag ccagagagaa aggccaggtc atctacaaag ggaagcccat 47400
cagactaaca gtggacctct cagcagaaat cctagaagcc aaagaaactg gaggccaata 47460
ttcaacaatt tttttatttt ttgttttttt gagactgagt ctcgctctgt cacccaggct 47520
ggagtgcagt ggcgcgatct cagctcactg caagctccgc ctcccgggtt cacgccattc 47580
tcctgcctca gcctcccgaa tagctgggac tacaggcgcc cgccaccgcg cccagctaat 47640
tttttgtatt tttagtagag acggggtttc actgtgttag ctaggatggt ctcgatctcc 47700
tgacctcgtg atctgcccac ctcggcctcc caaagtgctg ggattacagg cgtgagccac 47760
tgcgcccggc ctcaacattc ttaaagaaaa gaatttccaa cccagaattt catatcaggc 47820
caaattaagc ttcataagtg aagaagaaat aagatccttt tcagacaagc aaatgctgag 47880
ggaattgtta caaccaggac tgccctgcaa gtgctcctgc aggaagcact aaatatggaa 47940
agaaaaaact taccagccac cacaaaaaca cactgaagta cacagaccag tgacactatg 48000
aaggaaccac ataagcaagt tggcaaaata aacagctagc gtcatgatga caggatcaaa 48060
ttcacacata acaacactaa ccttaaatgt aaatgggcta aatgccccca ttaaaagaca 48120
gagaatggca agctggccaa agagcaaaga cccgtcagca tcagcaaaca cccagatgct 48180
gtcttccaga gacccatctc aagtgcagag acacacatag gttcaaaata aaggaatgga 48240
ggaaaattta ccaagcaaac ggaaaacaga aaaaagcaag ggttgcagtc ctagtttctg 48300
acaaaacaga ctttaaacca acaaagataa aatagacaag ggcattccat aatggtaaaa 48360
ggctcaattc aacaagtagc gctaagtatc ctaaatacat atgcacctaa tatgggaaca 48420
accagactca taaagcaagt tcttagagcc ctacaaagag acttagactc ccacacaata 48480
atagtgaaag actttaacac tccactgaca atattagaca gatcattgag acagaaaatt 48540
aacaaagata ttcaggacct gaactaaact ctagattgaa tggacctgat agttatctac 48600
agaactctcc acccaaaaac aacagaatat acattctttt catagccaca tggcactcta 48660
aaattgatca tataatcaga agtaaaacac tcctcagcaa atgcaaaaga actgaaatca 48720
taacaaacag tctctccaac cacagcacaa tcaaattaga actcaagaat aagaaattca 48780
ctcaaaacca tacaactaca tggaaatgaa caacctgctc ctgaatgact cctgggtgaa 48840
taatgaaatt aaggcagaaa tcaagaagtt ccttgaaact agtgacaaca aagagacagt 48900
gtaccagaat ctctgggaca cagcgaaagc tgtgttgaga gaaatttata gcactaaatg 48960
cccacatcaa aaagctagaa agatctcaaa tcaacaacct aacatcacaa ctaaaaaaac 49020
tagacaacca agagcaaaca aatcccaaag ctagcagaag acaagaaata accaagattg 49080
gagtggaact gaaggagata gagacacaaa aaaaaatttc aaaaaaccaa caaatccagg 49140
agctgatttt ttttgaaaaa aaaaaagtta ataaaataga ctgttaccta aactaataaa 49200
gaagaaagag aagaatcaaa tagacacaat gacaaatgat aggggggata tcaccactga 49260
cctcacagat acaaacaacc atcagagaat gctataaaca cctctatgca cataaactag 49320
aaaatctaga aggaatgggt aaattcctgg gcacaaacac ttgcccaaga ctgaaccagg 49380
aagaaattga atccctgaat agaccaataa tgagttctga aattcaggca gtaacaaata 49440
gcctagcaac caaaaaaagc ccaggaacag acgaatttac agctaaattc taccagaggt 49500
acaaagagga gctggtacca tttcttctga cactatttca aacaattgaa aaggagggac 49560
tcctccctaa ctcattctat gagaccaaca tcatcctgat accaaaacct ggcagagaca 49620
caataaaaaa acaaaacctc ggacaaatat ccctgatgaa catcaataca aaaatcctca 49680
ataaaatact ggcaaaccaa atccagcagc acatcaaaaa gcttatccac cacgatcaag 49740
ttgacttcat ccctgagatt caaggttggt tcaacatatg caaatcaata aacgtaactc 49800
atcacataaa ccacatgatt atctcgatag acacagaaaa ggcctttgat aaagttcaac 49860
atctcttcaa taaactctca ataaactaag tattgaggaa tatacctaaa aataacaaga 49920
accatctatg acaaacccac agccagtatc atactaagta ggcaaaagct ggaagcattc 49980
cccctgaaaa ctggcacaag acaaggatgg cgtctctcac cacttttatt caacctagta 50040
ttggaagttc tggccagggc aatcaggcaa gagaaagaaa taaagtgtat ctaaatagga 50100
agagaagaag tcaaactgtc tttgtttgca gatgacatga tcctatgtct agaaaacccc 50160
atcgtctcag cccaaaacct tcttaagctg ataagcaact tcagcaaagt ctcaggatac 50220
aaaatcaatg tgcaaaaatt gctaacattc ctataaacca acaacaggca agcagagagc 50280
caaatcatga atgaactccc attcacagtt gctacaaaga ataaaatacc taggaataca 50340
gctaacaagg gaagtgcagg gcctcttcaa ggagaactgc aaaccactgc tcaaggaaat 50400
cagagaggac acaagcaaat ggaaaaacat ttcatgctca tggataggta gaatcaatat 50460
tgtgaaaatg gccatatggc ccaaagaaat ttatagattg aatgctattc ctattaaact 50520
accattgaca ttcttcacag aattagaaaa aactattata aaattcatat ggaaccaaaa 50580
aacagcccca atagccccaa tatctttttg cttaggattc taagcaaaaa gaataaagct 50640
ggaggcatca tgctacctga catcagactg tagtacaaga ctacggtaaa caaaacctca 50700
tggtactggt acaaaaacag atacatagac caatggaaca gaatagagaa ctcagaaata 50760
agaccacaca cctacaaaca tctgatattc aacaaatctg acaaaaatga gcaatgggga 50820
aaggactccc tatttaataa atggtgctgc aaaaactggc tagccatatg tagaaaattg 50880
aaagtggacc ccttccttac accgtataca aaaattaact caagatggat taaagactta 50940
aatgtaaaac ccaaaactgt aaaatcccta gacgaaaatc taggcaatac cattcaggac 51000
atagacattt catgacgaaa atgccaaaag caattgcaac aaaaccaaaa attggcaaat 51060
ggggtctaat taaagagctt ctgcacagca aaagaaactg tcatcagagt gaacagacaa 51120
cctgcagaat gggagaaaat ttttgcaatc tatccatctg acaaaggtat aatatccaga 51180
atctacaagg aacttcaaca aatttacaag aaaaaaataa ccccattaaa aagtgggcaa 51240
agggcatgaa cagtcacttc tcaaaagaag acatacatgc agccagcaaa catgaaaaaa 51300
agctcaacat cacagatcat aagagaaatg caaatcaaaa ccacaataag aggtgggtgg 51360
gtcacttgag gtcaggagtt caagactaga tctagaatca gaaataccat ttgacccagc 51420
agtcttatta cggggtatat acccaggaat ataaatcatt ctattataaa gatacatgca 51480
tgcataactt cactgcagga ctattcacaa taacagagac atggaatgaa cccaaatgcc 51540
catcaatgat agactggata aagaaaatgt ggtacatata taccgtggaa tactatgcag 51600
ccataaaaag gaataagatc atgtcctttg cagggacctg gatggagcaa actaatgcag 51660
gaacagaaaa ccaaacactg catgttctca cttataagtg ggagctgaac tatgagaaca 51720
catagacaca tatggggaga acaacacaca ctggggcctg ttggggaagg ttgggggagg 51780
gagagcataa ggaagaacaa ctaatggatg ctgggcttaa tacctaggtg atgggttgat 51840
ctgtgcagca aaccacctgg cacatgttta cctatgtaac aaacctgcac aggtaccctg 51900
gaacttaaaa gttaaaaaaa ttttaaaaag aagagaactt cctcaacctg ataatgtgca 51960
tctataaaaa aacctatacc taacatcatt tttaatggta aaagaccgaa tcctttccca 52020
ttaggatcag aaagaagaca agatatccac tctcacgact tctattcaac actggaggtt 52080
ttagccagtg caataaggta agaaaaataa acaaaagtca cctacttttt aaaaaaagta 52140
agaatgaaaa tatttttacc ctcagatgac ctgatcacct atgtagaaaa tccagtgaaa 52200
catttaaaag gaagaaacag ggcaggcatg gtagctcacc cacccaaagt gtaatcccac 52260
cactttggga agctgagaca gaaggatcac ttgaggtcag gagttcaaaa ccagcctggg 52320
cacagagtga gaccttgtct ctataaaaaa ttaaaaaatt agctgggcat ggtggtgcat 52380
agctttagac ccaaacactt agaaggctga ggtgggagga ttgcttgaat ccaggagctt 52440
gaggctacag tgagctaaga ttgtgccact gcactccaaa ctgggtgaca gagccagacc 52500
ctatctctaa acaaaacaaa actactagaa ctaatacatg agtttagcaa ggttgcagga 52560
tacaagatca atgtacaaca ctcaactgta tttccatata ctaacaacaa ataattgaaa 52620
aagtgaaatt aaaagcaata ccatttacaa cagcatcaaa tagatgaaat atttagggat 52680
aacctaacaa acaatgtgaa atgcctgtac actgaaaact ttaaaacatt gctaagagaa 52740
tttttaaaaa tctaaataaa tggagataca ttgtgttgct gggttggaag actcaatatt 52800
gtttaaatgt cagttcttcc ctagttgatt tatagactta atccaataac agtcacattt 52860
cctttttttg tataaattga caaactgatt ataaaattca tgtgaaaata tgaaggacct 52920
agaatagaca aaacaacttt taaaaagaat gaagttggaa gactaggacc acctgatttc 52980
aagacatatt acaaaactaa cagtaatgca gacagtttgg tactgggcaa ggatagacat 53040
attcatcaac agaacagaat agactacaga aataaatcca catgtatatg gtcaactgat 53100
tttcaacaaa ggtacaaagg caattcagtg gagaagggac agtcttttca gcaaatactg 53160
ctggaacaaa tgtatatcca tatgcaaaaa tgaactttga tctagctaca tgttacacca 53220
tattaagaaa ttaactcaaa atggatcaca gacctattta taaaacctaa acctgtaaag 53280
tttataaaag aaaacatata agaaaaattt tgtgaccttg gaataagcaa atatttctta 53340
ggtacaatac caaaagcatg gtccataaaa gaaaacactg atgaattaga ctttttaatc 53400
attaagaaca tcttctcttt caaagagaat cttaagagaa tgagaaaaag ccacagacta 53460
gaataaaata tttgaaatca tatatctggc tgggtgtggt ggctcacgcc tgtaatccca 53520
gcactttagg aggttgaggt gggtggatca cctgaggtca ggagttcaag accagcctgg 53580
ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa aaaatgagcc atgcgtggtg 53640
gaggcacctg taatcgtagc tactcaggag gctgaggcag gagaattgct tgaactcagg 53700
aagcagaggt tgcagtgagc caagattgct ccattgcact ccagcctggg tgacaacagt 53760
gaaactccat ctcaaaaaaa aaagaaaaaa aaaaactcta aaaacgcaat acagtggtgc 53820
tcccttatct gtggttttgc tttccatggt ttcagttacc tgtggtcaac catggcctga 53880
aaatattaaa tggaatattc cagaaataac caattcatag gttttaaatt gtacaccttt 53940
ctgaggagca tggtgaaatc tcatgctgtt ccactctggc ccacccagga cacaaatact 54000
ccttttgtcc aacatatcca tgccatatac actacctgcc tgttagtctc ttagtagcca 54060
tcttgattat cagattgcct gtcatggtat tgaagtgctt tgtgttcaag taacccttat 54120
tttgcggtgg ccccaaagtt caagagtaat gatgctgaca tattgttata atttggtatg 54180
gtttggctct gtgtccccac ccaaatctca tctcaaattg taatcctcac atgtcaaggg 54240
agggacctgg tggaaggtga ttgggtgatg ggggcagttt ccctcatgct gttctcatga 54300
tagtgaggga gttctcacaa gatctggttg tttgttaagt gtctggccct ttcccctgca 54360
cactctctct ctcctgccac cttgtgaaag tgtgtcttgc ttcccctttg cctttcgcca 54420
ttattgtaag tttcctgagg cctccccagc catgcagaac tgtgagtcaa ttaaacctgt 54480
ttttctttat aaattattca gtctcatgta gtacctttat agcagtgtga gaacagacta 54540
atacataatt gttttattat tagttatggt tgccaatccc ttactgtgcc taatttataa 54600
attaaacttt attataggta tatatgtata agaaaaatca gtatatatgg ggctcagtac 54660
tatccatggt ttcaggcatc cactgggggt cttggaatgt atcccccctc agataagggg 54720
gactattgta ataagaaaac aattcaatat tttaaaatgg gtaaaagatt tcaacagata 54780
cttcaccaaa gaagatatat ggatgacaaa taagcatatg aaaagatgtc caataccatt 54840
actcattaag gaaatgcaaa ttaaaactac attaaaatac cactacacac tcattagaat 54900
ggctaaaatt aaaaagactg agtaaatccc atgttggcac acactgctga ggagaacata 54960
atttggtcca accacttcac tttggaaggc agtctgggag attatttatt tatttattcc 55020
attcctggct gatttttttt atagaaatag agtttcacta tgttcctcag gttggtctca 55080
aactcctggg ctgaagcaat ctgcctgtct tggcctctca aagtgctagc attgcaggca 55140
tgagccaccg cgcccggcca tggcagtttc tttaaaagtt cagcatatac ctatgatgtg 55200
atctagctat gccactctta ggtttttacc caagagaaat gaaactgcat gtccatacaa 55260
agacttgtac gccaatgttc atagcaactt tctttgtaat agccaaaaac tggaaatagc 55320
acaaataccc attagcaagt gaatggctaa acaaattgta gtatatccat acaatagaat 55380
cctgctcagc aatttaaaac atgaattatt gatacttgga agaacaaaga tgaatctcaa 55440
aataattaca ctgaatgaaa gaagccaggc aaaatgacta catgctatgt aaatccaatt 55500
ccacaaagtt ctataaaact aaactaatct attgttaact aatctgtagt gacagaagca 55560
gatcagtcgt tgcctgtgga tgagtagggt tggcaaagag tcaggaaagg aggatgacaa 55620
aggggcatgt ggaagctttt tggggtgatg gatatgttta taccttgatt atggtatttc 55680
acaggtgcat acatatatca aaacttatca aatcatgtac tttaaatatg tatgtcatgc 55740
actttaaatt gtgtgccagt tataccttaa taaagctagt aaaactatta tacattctta 55800
tttttctgag caggttctca tggagaacaa aatacaccat acctagtgtt cgttttcttt 55860
tttttaatta attaattaat tgatttttat tagtgttcat ttcaaaggac cttgctaggt 55920
gtcctaaaac ctatctgatg actttgcctg atactgatga ttttattatg attttaaaaa 55980
atatttttag tagagacggg ttttcgccat gttgggcagg ctggtctcga actcctgacc 56040
tcaagtgatc ttcccacctc agcctcccaa agtgctggga ttacaggagt gagccaccat 56100
gctcagccaa tactaataat tgatatggga gaatgttttg tttttcctag attcctcatg 56160
cagcttaata aggaccataa taacttaact cttagaacaa aggagatatt tcaggcccaa 56220
agggaagcac atctggtgcc tcctctgaaa ttcacaaaat aagggcgttg ttgtaagttc 56280
tgcatgaagc taaacttgtt caaagtttat aagttcaaaa gtaaataaaa ggactatctt 56340
ttattctgag accttatttc aatatcactt gtgataatga ttatagatcg tagctgttat 56400
ttacatattg ctacttctca gggttaaagg tggcatttcc acagcagtat ctgggatttt 56460
attgcctatg aaatcaagaa ggtagagtaa caagaattgt gtagggtatg agcttttacc 56520
ttacatgcaa gttaacaagt tagcctggta atgtttgatg gatgttagct aaagacatga 56580
gactcttggg tcagagaaaa aacacttgat tactcatggc aaaagcagta atcagaactt 56640
aatattgagc ttttactggt ttccatgccc cacgtgccat gaggggaatg aaagtcccat 56700
aatggatgtt tatggatgtt tgcacacaca cagtgggcta ccatttaagg agaggaatcc 56760
tgagcctggt aagtccactg cttttatagt gagttgtaac aagcctgttc tttgtctagg 56820
ggaagatgtt acctgatccc tcaaggttgc tcattacaaa cacaaccctg agaaatggcc 56880
tggataaaga gcagtcagag ccttgcttct tggcatacct gacaagaatg cacagagctg 56940
ctcagggccc ctggtaggtt tgcctcccac actagggact gtgcatggag gcacctgcca 57000
cttctgcctg catcctgggc tagcgtgaca gtcagagaca cagacaccag tgaatggctg 57060
aaatatgttc ctgtggtctt ctcactccac tacaacttcc ttcccagtta gggtccccat 57120
gcaggccctt tgagctgcac ctggcagagt tgagttacat actttcatgt accctgctga 57180
gtttgtcttc tttgccttca gaaattccaa catactacat gagtcatggt tcttggtatt 57240
attgttatac ccttctcaga atctctctga ctccccagat ttcacatcgt tttccatttt 57300
tgtaaaaggc ctcaaggtct ccatgctatg gagaagagtt atactcatct tttctttatt 57360
cttgcattcc tgaaagcctt acattagcat ccaagtgagg tttctctatc aatatcaaca 57420
gtaaatattt agtgaactaa acacctacta tgctcagcat aatgtataaa atatgattta 57480
agggttcctg ggagcttcaa atgcatcacc tgggtgcaaa aacatgagga aaccaaaaag 57540
tacattctgg tggttttttt aatagcattt aaaaaataat gccttgctgc agggatagga 57600
gctgtgctgc tttcatatca attctgttct ctttgtggtt tgagaaactg gagctgaagg 57660
gaaggtgatt gggaataaaa gaaagcagta ctgatttttc tggctaaaag aaagtttgca 57720
cactgtcatg cactattaga atttctggga tcttctttat aatccccggt ttgatggtta 57780
ttggccaaga aggaagaagg ggagctagtc aggcctagaa taattaccag ccatacagca 57840
taatctgggg ctagtgttgc agggtcaagg actgaatgag gcagagtgac caggagcaga 57900
tcctgcaagg ccttgaccaa aaaggaagct aaggttcata gaaggaaaat attgtattga 57960
tcatcaattc tagaggattg ggcatagagc caaaaatagg aggtgtatca tgagatcaaa 58020
agccattggt ggccaagcgc gatggctcac acctataatc ccagcacttt gggaggccaa 58080
ggcgagcaga tcacttgagg ccaggagttc aagaccagcc tggccaacat ggcaaaaccc 58140
tgtctctacc aaaaatataa aaattagctg gccatggtgg cacatgcatg taatcccagt 58200
actcaggagg ctgaggcagg agaatcactt gaacctggga ggcggaggtt gcagtgagcc 58260
gagatcatgc cactgtactc caacctgagt gacagagtga gaccctgtct caaaaaaaaa 58320
aaaagccact ggtatgtagg aatggtgcag gaaaaaagtg caaagcagaa atgaggtgaa 58380
aatatataga actatgaaca ggaatgaggt ctttcttgag tactggctgc cagatggagt 58440
acgagtgggt cagcagaagt taatgaggta ggttaaaagt taatgcatag gaatagtttc 58500
tgcacagtct tctgatgctg tccatcctgc agtcaggcct atatcaatat cagccctaga 58560
tgaagtggtc acaccctcct ttgtgcacct actgttacaa atagtcatgg ctgtcattac 58620
tccatcacag ctgatggcac ttactaggtt gagagaagcg gggctctgtc tcccttacca 58680
tacagtgagc tccttgagtt tattcatctt tgtgtttcca ttgtgcctgg actgcgcact 58740
gtttcccgaa tgaacaaatt aactggccta gaatatatct atgatgataa aggtcagttc 58800
ttagattatt gttttcattc tttaactgtt taagataatg tcaactctat gtaaaaattg 58860
tgccctaggt aagcagttgc tttttattat tattctctct ctttcttgat ggttactccc 58920
tctaggagcc caaagcatga cgtccagagc cccagattcc cagccatcct ggttgtgacc 58980
cttcattctc aactttcatt tcaatcttag tatgccatga aaagccgtct gcttttgaag 59040
cactatcagc cacagagttc tgtactttta gaaggccttc tcatagtcag attctcacaa 59100
atatacctat tgtttcaata aatatttatt gaattggcca gcaatgtttc agatactgtt 59160
ctaggtgctg gggttacatc aaagaacaag gtaggcaaaa tcactaccct cgtggacttt 59220
gctttcctgg agggggaata ggcaggacat aaaataaatt gtaaactatt cgggatgtta 59280
gtgatcagag aagaaaagta aaacagggac agtgaatggg gactgtcaga gtggtagttg 59340
ctattcaaga tcatttgacc aaggaaggcc tcgctgagga agtaacattt gagaatagac 59400
ttgaaaggca taaaaaaaca agtcattagg taaaaaccat tccaggcaga aggaacaaat 59460
aatgcaaagg gccagggatg gaaacatctg tagtgttcag gggaaagcaa ggaggccagt 59520
gtgactggag cagagtagat taggcaaaga acaggagtag ataagatcag caaggtaatg 59580
ggtgccacat cacgtaaggt cacacaggac agtgtaatga ctttggcttt tactctgtta 59640
tggggagcca ttgcaggatt gggagctgtg aaatggcaca ccttgcttac atctaatagg 59700
aaatctgctg ctgcattgag aatagacctt taaattttaa aagagatatc tatggcatta 59760
ccttaaataa agtcatgctc cttggagtgc ctcaattcat gtacattaat gggtaaaagt 59820
ggaattcaag aaaccctgga aatgtatggg ggagtcctct ttgtttctcc tctgctcatg 59880
tctggtgggt gagcactaac gccatctctt cctaagcgag ggctccctag cagagcaccg 59940
tgcacatgga ttcttcctat gctctgcatt ctttgccaca gggatgccat aatttggcaa 60000
tatgcagtag agactgcctc aagaggcagt tcccttcttt atctaagcca agagaaattt 60060
ggttctgcaa gtaacaagta attactgctg atgacattcc ttgtacacac ttgaagagag 60120
cgtggaccgc aaaataaaaa ctggagcaaa aagggactat cagataatcc agattaaaga 60180
ttggaaagga ggaaaacaca ttatttacac atacaacact tgattttatg agtagagaac 60240
acaacttatg tgtatgtacg ttgtacactt gattatatgt gtagagaatt caaaagtgtt 60300
cagataaatt atttagactt aaaaagagac aaataatttt gggaaggtga tagtggcagt 60360
agtagcatag gttttagata ttcctgaatc tccacataaa aacagcaact agatagaaga 60420
cacaaaactc atgggcaaca aaataaaatc catttacaag aaaattagat gatgaggtat 60480
tcttatgatc ctcaaaatat aaccggttgg ggaaagacca cccacagcca caagagctgt 60540
gttatttgtg tctacgtagg agaaataaga gagaggcaat ggacatctga cagacctgag 60600
aacagagaac tcaaaatagc ccaaaggtat tcactggaaa gcatgggtgg ggcaatttga 60660
gatcagcagc tgaaacttaa taaggggtga gtgcaaggga tccacctctg gaaggtctaa 60720
aaggaatgca gcagtctagc tgctgtgaaa tttctagact gatctggtgg ggctcccttc 60780
caagatagga tctcatgaag aagagaaact gtggggagta ttgagctcaa aattgagcag 60840
aatgaagaca atacagatga agaaggaaga ggaatatcca aatgaaagca tatcagagtc 60900
aggaaatctc cttggaaagc aagccagagt attttttaac accatattaa tacaatatag 60960
caaaggaacc atgtgaagtt agaaaagcta tctgaaccaa atgtcttttt aaaatcacat 61020
aaaaactaaa ttcacaccca caaaaatcta cagcaggaaa atatcaaggc caaatccaac 61080
acaacattat taacctaaga aagagaataa ggggaatatc tgcagacaat gaaagcatgc 61140
caaaaagata tgattgaaaa tagattgaga ccctaatgta ctatttcagg tgcattcaaa 61200
gacattgaag aagtcatata agacatagaa aagcaacata aatcaaatta ggaagctcag 61260
aaatgagaca attcaagaaa aaattagaaa taaacatcta aaaatgaagg ctgatctaga 61320
aggaactcaa caacaaatga atacaacata attctttaac ataaataaaa ggtagaaagg 61380
aagaaaattt tttaaatgga atgaaaaaag atttttaaaa agttttgaaa gaaaacaaca 61440
aatattgaaa ataggcaaaa aagatcaatt tatcaataat aagagtccct gaaaaagaaa 61500
ataaaagcaa ggaaagaaaa caagtataaa acaaacaaaa ccctctaatt taagaaaact 61560
gaaaatttga aactacgtat ggaaagaaca cactgtgtac ttgagtatat cataatgact 61620
aagttcagca gagttgttgg atgaaaggtc tatgtgtaaa caccatttta tgtaacattt 61680
aaacaaattt tttagatcat ttaaaacagc ataaaaaata taaaatccta tttgtgacgg 61740
ctttctagtg tgtcaacttg actaggccaa actacatttc ctagaattct ctttcttgta 61800
tgttttctga ccacaaagga gattctttct agatttggaa agctaaggga agttccagcc 61860
atcttatagc acacacattg ttgcgaacct gctgatccac ctactggggt gaagcagagc 61920
tggacatgca attgctctac cttcccctgg accctccatt aacttgtcag gcccctgggc 61980
caggtgtgtg tgattagctc cacgacaaag ggccacagct tctgcaggat atactcatta 62040
cctagatcag aggcaacaat aactgacatg ggtttcagtc tcttcacagg ggtgtgagca 62100
tgctctaatc tcttgatttt ccctcctgac tgcctgcctt gtagacttca agctctagca 62160
tcagatgtgg agacaacagc cttacagaga ctgcttaaag agctcccaaa attgcataac 62220
tcaactgcct gtgacacatc catatatctc tttttgaatc ctggctaata cagtaggaaa 62280
agatatgcat tatctctata tagaaaatca taaaatattt tgagaggaat taaattctat 62340
attcattgat cagaagactt aatattgtaa aaatatcatt tctccccaga ttgatatata 62400
ggttcaatgc aatagaaatt ccaacaactt gcatatgtgt gtgtgaaact tgacaagcta 62460
aatctcaaat ttatacggaa attcaaaggg ctaaaaatag gctggaaaga aaaggacaag 62520
ctgggcgcgg tggctcacgc ctgtaatccc agcacttttg gaggccaagg cgggcagatc 62580
acatgaggtc gggagttcga gaccagcctg gccaacatgg cgaaacaccc tctctactaa 62640
aaatacaaaa atttgccggg catggtgggg ggcgcttgta atcctagcta cttaggaggc 62700
tgaggcagga gaatcacttg aacccaggag gcagaggttg cagtaagcca agatggcacc 62760
attgcactcc agcctggatg ataagagtga aactctgtct aaaaaaaaaa aaaaaaaata 62820
ggacaaagtg agaggatttc ttcttctgga tatcaatatt tactataaag ctagtaatta 62880
aaacctgcta aatatggtat tggagcaagg agagacaaat agatcaatag aacagaatag 62940
agagaatcca gaaagagtca aggatatata gatgcttttc aataaatggt gcagggtcag 63000
ttggctatcc acatggagaa aaaagtgcaa cctgaatcca cctcaacaaa attacttcca 63060
ggtgaactac tgaaatggaa aacaaaaaaa cttcaggaaa gtcatagaag agagtatctt 63120
tatgaactag ggacatgaaa atatgttaaa cagaacacaa caagtattat tcataaggga 63180
aaatattgtt aaattgctct acattcgttc aggagcagcc tgggcaacat ggcaaaatgc 63240
cgtctctgct aaaaatacaa aaatacagcc aggcatcgtg gtgcatgcct gtggtcccag 63300
ctactctaga ggctgaggtg ggaggatcac tggagcctgg gaggcagagg tcacagtgag 63360
ctgagatcac gccattgcac tccagcctgg gtgggtgaca gaggaagacc ctgtctaaat 63420
tgaaaaaaaa aaaaaagctc tacattagaa attgagaact tctgttcatt aaggacatca 63480
ctaaggaaaa aggcaagcca tagactggga caatgtattc acaatgcata tgtcatcaaa 63540
gaatctttat tcagaataaa aaagtgggaa tctatatgaa aacatagaaa atccactttt 63600
ttaaaaatgt gcagtcttat gtttatcaca gcactgttca cagtagtaaa gtcatagaat 63660
ccatctaagt gtccatcaac agatgattgg attaaaatgt ggtatatttt tgccatggaa 63720
tactatacac ctataaaaat aaatgaaatt atgtcttttg cagcaatgtg gatggaactg 63780
gaagccatta tgcttactga aatgactcag aaacagaaaa tcaaaaacca catgttctga 63840
ttgataagtg ggagctaaac agtgggtata cacggacata caaggggcat aatagacact 63900
ggagactcca aatggtggga ggatgggagt gggtgaggga tgaaatacca cctttcaagt 63960
acagttcagg tgattggtac acttaatgcc cagatttcac cactgtgtaa tatatccatg 64020
taacagaact gcatttgtat ccctaaatcc ataaaaataa aaaaatttaa tttcaaaaaa 64080
taaaaaatgt gcaaaagata tgaacaggta catcacaaaa gaacaaatcc agatagccaa 64140
taaacaaatg aaaaagggct caacttcatt agtcatcaga gaaatgcaaa ttaaagccac 64200
agtgtgataa tactacatac tcacttgaat gtctgcaatt aaaaaaaaga ctgacaaaac 64260
caagtgttga gaaggatgta gaacaactgg aattctcatg catagtgtgg aagtgtgcat 64320
tgatacaatc acttttgaaa actgtttagc agtatctact aaacttgaac atattcatac 64380
cctgtgtcct agcaattcca gcaaaattgc atacatatat tcaccaaaat aatgcactag 64440
aatattcata gcaacactat ttgtaatagg cccaaattgt aaactgtttg aatgtccatc 64500
aacagttata atatctattt ataatgtcca atatatcaca gtatactcca tgccacaata 64560
tagatggctc tcacaaaaat aataaatagt gttgagcaaa ggaagccaga aaaagagatt 64620
ataccctatg ttactctttt tacatgatgc acaaaaacag gcagagctaa tctaagatgt 64680
tagaagtcag attgggtggg tggagaaaag ggagaataga gcaagaggaa gacttctgaa 64740
gcactaataa tatgtttttt gacttgcatg ctggttgccc aggtgtgtca gtttttgaaa 64800
attcagtgaa ttatacattt atatatatgc atttttgttt atgcatattt ttcttcagca 64860
aaagtttaaa aaataatctt tgggcttcct gaaaagataa aaaggaaacg tttaaaggat 64920
acatgtcaat tttttagcag agacaaaatt tttaaatact attttctgaa aaaaaattct 64980
ccctcacagc tttatattta ttattaatat tgaaggatat aatgaatagt tttactgtaa 65040
atgcagaagt aaattttata agacttgttt atggcaccat taggaatagt ttttaaaaat 65100
cagaacttgt gtttatcaaa agacactatt aaatgacacc aaaagcacaa gtaacaaaag 65160
aaaaatgtgt ttaatatcat caaaattaaa aatttctggc caggcaccgt ggctcacgcc 65220
tgtaatccca gtactttggg aggccgaggc aggcagatca caaggtcagg agtttgagac 65280
cagcctgacc aacacggtga aaccccatct ctactaaaaa tacaacaaat tagccaggca 65340
ttgtggtgcg cacctgtaat cccagctact tgggaggctg aggcaagaga atcgctcgaa 65400
cccaggaggt ggaggttgta gtgagcgaga tcttgccact gcactccagc ctgggtgaca 65460
gagcaagact ccacctcaaa aaaaaaaaaa aaaaaaaatt ctgtgcttca gataacacca 65520
ttaagaaagt aaaaagaacc tacagaatga agaaaacgtt ttcaaattat ataatagacc 65580
tgataaggga ctcacatcta gatatataaa gaatgcttac aactcaataa tacaaagaca 65640
aataaaacaa tttttaagtg ggcaaagaat ctgaatagaa gtatctcaaa aaagatatat 65700
gaatggccag taggcacatc attaccccta agggaaatca aaatcacaat gagttaccac 65760
tttgcatccc ctaagatggc tataatataa aaattaacaa gtgtttgtga ggctgtggag 65820
agattagaac cctcattcac tcctcctagg gatgtaaaat agtgtctgag ctagggaaat 65880
agtttggcag tttcccaaaa tgttaaacat agggttacca tatgactcag tgattaagct 65940
cctaggtata tactcaagaa aatcaaaaca tatgtccatg taaaaacttg tacatgaata 66000
ttgatagcag cattgtttat aatatcccta aaaggaaaca acccaaacat gtatcaacta 66060
ttgaatggat aagtgaaatg tgttatatcc atacagtgaa atattattca gcaattaaag 66120
tgacacactg actcatgcta ggacatggat gaaacttgaa aacatgatgt taggtgaaag 66180
aagctagtcg caaaagatca catttgattc catttatatg aaatgaccaa aatagacaaa 66240
tctataggga cagaaaggag attcgtggtt atatgtggct ggggaaatgc aaattaaaac 66300
tactaggaga tacataccga tggtatgtat gcttatcttt aaattatctt taaatttttt 66360
aagataataa gataaagatg tgaaactatg aaactctcat ttactcactg ggagggtata 66420
aactggtaca accacattag aaaagaaatt ggcgtatctt ttaagattaa caacacatat 66480
accttgagag ccagcaaatc catttctaaa ttctactcag tagaactatg tgcatattta 66540
tatcaatagg tgtacaaaaa tattcatagc agcattattg taatcaccca aatgttcatc 66600
agaagtataa ggaataaata aattgtggta tattcctgca atgggatatt atatagcagc 66660
tacagttaca cccagcaaca tgtataaatc tcacaaacaa catcaaataa aaaagccaac 66720
cacaaagtag catccactat gattcccatt tatgaagttt aaaaacaggc ataactcaac 66780
tatagtatta aaagtcaata tagtagttca ccttaaggga gaagggaaag agtaaaaagt 66840
ataatatgag gtagaatttt gaggtattgt aatgttctct ttcttgggtt atagttttct 66900
atatgatgtt ttctttgtta caatttactg agctatacat ttttaatttg tacacttaaa 66960
aatacatttc ctggccaggc gtggtggctc gtgcctgtaa tcccagcact ttgggaggct 67020
gaggcaggca gatcaggaga ttgagaccat cctggctaac acagtgaaac cctgtctcta 67080
ctaaaaatac acaacaaaaa ttagccaggc gtggtggcgg gcacctgtag tcccagctac 67140
tcaggaggct gaggcaggag aatggcgtga acctaggagg cggagcttgc agtgagccga 67200
gattgcacca ctgcacttca gcctgggtga cagagcaaga ttctttcaaa aaaaaaatat 67260
atatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtatgtgt gtgtgtgtgt gtctgtgtgt 67320
gtgtgtgtgt attctggccc aagattatag ttttttttaa ggcagtctgt caggggtcta 67380
caattgtatg agttataaat aaggagtgac aatatcttca gtgaactcct gaacatgaaa 67440
accaagggtc gactgcgaat accttcttta catacaacca gacattatgg aatgaatgtg 67500
ttccccccaa attcatatgt tgaagctcta actcccagtg tgtctgtatt tggagatagg 67560
gtctttgggg aagtaattaa agttaaatta ggtcatacaa cctacagaat tggagaaaat 67620
atttgcaaac tgtgcatctg acaatggtct aatacccagc atctataaga aacttaaatt 67680
tacaagaaaa aactaacaac cctatgaaaa agtgggcaga gttaattttt tcatgagcaa 67740
tggaaaaaaa ttaaaaagtc tgaaagcagg caaagaacat gaacagacac ttttcaaaag 67800
aagacataca tgcagccaac aggcatatga aaaaaagctt agtatcactg atcattagag 67860
aaatgcaaat caaaaccaca atgagatacc atctcacacc aattggaatg gctactatta 67920
aaaagtcaaa aaataacatg ctggcaagat cgcagagaaa aatgaacaca tacactgttg 67980
gtaggagagt aaattagttc aacattgtgg aaagcagtgt ggcgactcct caaagagcta 68040
aaaacagaac taccattcac cagcaattcc atttgtggtt gtatacccaa aggagtataa 68100
atcattctac cataaagacg caggcacatg aatgttcatt gcagcactat tcacaatagt 68160
aaaggcatgg aatcaaccta aatgcccatc aatggcagat tggataaaga aaatgtggta 68220
catatacacc atggaatact atgcagccat aaaaaagaat gagatgatgt cttttgtttg 68280
aacatggata gagctagagg ccattatcct tagcaaacca acacaggaac agaaaaccaa 68340
atactgcatg ttctcactta taagtaggaa ctaaatgatg agaacacatg gacacaaaga 68400
gaggaaaaac acacactaca cactacctga gggtggaaga tgggaggagg gagataatta 68460
gaaaaaataa ctgttaagtc ctaggcttag aacctgggtg acaaagtatt ctgaacaaca 68520
aaccccccga cacgagttta cctgtataac aaacctgcac atgtacccat gaacttcaaa 68580
taaaagtctg tgtgtttttt aaggcagaag tcagccccta ccttgaaaga actttctaca 68640
tagatggcta cagtgttact gagcgttttt tttttggtct atcctgaatg tcatgggaaa 68700
acttttaaac tgctctggat caagattagt gcctgtggta tttcatttct cctactcaac 68760
tgttgcagtt acatgatctt agaaattctt tttggcatat tgatgactgt tatcattcaa 68820
gttacatcaa gagagacttc tttctatgag gagctattaa gaccctcttt tggacacata 68880
cacaacttca atttacatct aagacaactt attttaatga aattgcttat ttgtttgctt 68940
tagtccttag attatatgat catttgggca gggactattc tttgaatatt tcctggcaca 69000
tttttgtctc aataaagagg aaggtgaagg aagaaagaaa ggaaaggaag aagggaggga 69060
ggaaggcatt cttgttttct atatcctaaa cctataattt tgtcaaaaaa gaatattaaa 69120
tttgcctaaa atgttaacaa aaaataggtc ataatgatgg ggccctaatt caacagggct 69180
ggtgtcccta taagaggaag aggcattgaa gtttgctctc cctgcatgca caaagagact 69240
atgtgaggac acagcaaaag gacagctgtc tacaaaccag gaagaggcct cgccagaaat 69300
cagcccttga aaaaacctgg gtcttggact ttttgcctcc acaactgtga gaaaataaat 69360
ttctgttgtt taagccaccc agcctgtggt gttttgttat ggcagcccga gcagactgat 69420
acaccagaca ttcactgtat ccaactgttt caccataata gcctttctta ttttgatcaa 69480
attactgcat caggatttga tcttaaattt catgtttcct ttgcttttgt aaatgtagct 69540
gagcatccaa atttcactca gtttggatgc taacaagatt agacagttat ctgacagtaa 69600
tcagtgcctg atcctattct gtgtcttctt ccatcaccat cccactaaag agcttgcatt 69660
ttttgtttct tttagccaga tagtaaacat ttttcaggca ttttgaattt tgccattgta 69720
aatggtgaaa gattctctct ctctctctct ctctctctct ctctctctgt gtgtgtgtgt 69780
gtgtgtgtgt gtgtgtgtgt attaggaggg ggtggtgatc gggatgctaa tctatgcaca 69840
gtgacctttg tttctatctg gctgagcaga tgtaggaatt aatcattgtc actcctggat 69900
ggtgctgctg cagctgtccc ccactgcctt tctgcccctg atagatttat tagtgtgttt 69960
tgtttgctga aaagcatgcc tcagcacaga agaactggca aattagagaa gctttatctg 70020
tgagtataat tttttggaaa catggttttt tctacacatc tgtacctata tactctgagc 70080
tctttaaaaa aaaggaggag gaagagagca aagaaagaaa aggaaaacaa acaggtaata 70140
ttgtttctgt aacatcagaa cgattatttc ccagctgaga atgttcatac tggaacagtg 70200
tcatggccat ccaccttagg attgcagaga accaattgtt ttctaacctc tgtatttctt 70260
tttgcaactg cccaccccct cacccactta actgccaact atcagccaga attttggcat 70320
actttggctc taggcacaag aaaataagtg gtctgggtta cttagtgcta aatttatttt 70380
atagtaggcg tcactacaac cttgagactg taactaacac tttctaggct ccaagcaacc 70440
ccactacgta gatatccctg cagcctcatc aaattcaacc cgtggggata ttgataccgt 70500
cctggatgga aatcagagta gccacacccc tttcaatgtt gggaatctgc caaacaattc 70560
agtataaatt tcctgggcct gggctgtgta ttttcattcc accccacccc caaatcagtc 70620
agcatgccct ggggcagaga ctaaagagcc gccagtgcct attcagagtt ggcttattcc 70680
tttctgatgg cccatcccct ccccgaaatc caagaccttg gccttagata tcttggctag 70740
cctgggcctt tctggtacca cccttcactc tctaggagct ctgagaattt tctgcacttc 70800
ccgacgctgc ttgatagagt gactcacagc ttactctttc attgactctt tctgtatttc 70860
tcttcttcag aatttctctt ctgctgctgc ttttagacat ccttgcatgt tcagtcccta 70920
aatcaccact gcttgttatt actttcatgt tcccaacatc tggcatatgg gtcttaatcc 70980
catgggtcca cccagactca tgaatttaaa ctcttctggt ctaaactctt ccaccaccat 71040
ttgagcctca attctgtgaa cagttttgtc tctaaaagcc acatacctta gtgtaagaag 71100
gcagattaat cctctgaatg tcaacttaac agttaggcct atctcccaag aaagagaaat 71160
gaaaactcct aattagtaat gactcatttt gatcaaataa tcaatttttg gaccattttc 71220
ttaaaactat attttattgc ctgtaactat ttcctggagg ataataatca tccttaaatt 71280
actatgtgtt ttgtgaagtt ggtgctttac ttttcgtgtc ctaaatatgc atatctgaat 71340
ctttaaattg tagcttctct ttcaagtgtt ctaggatttc atttgccatg gttgggatct 71400
ctttgtgatt tgataggttt cgatcacatc ctcactagcc ttctttccaa gccacagaac 71460
ggtctgtctt cattcagtag agaccctgcc attctagttt tctcgctgga atttgttttc 71520
ccatatcctt cttgagcaaa ggtgactaaa gccaaatgtt tcattctggc actttgtgag 71580
acgtgggctt taagctctca aaagaagaga aaatctcata gttttatatg agatatacaa 71640
tgaacaatag taaaatagaa atgttattgg caagaggagt ttttctccaa tatccatgag 71700
taagaattcc ttggacacat aagataacaa gaggaatata cttactctgt tttccttttg 71760
agatattctt tacataccat gaagttttcc tttctaaagt ttgcaattta atagttttta 71820
gtatattcac aagcttgggt aaccaccatc actatctaat tccagaacat ttttatcacc 71880
tgcaaacaaa accttgtacc tgttagcagt ctctcctcat ttctctcttc ctcccacacc 71940
tggaaaccac tagtctactt tctatctcta tagatttgcc tattctggac atttcatata 72000
aatggaatta ttgaacatgg ggccctttgt gtctggcttt tctcatttag cataatctta 72060
gcataatatt tataaggttt ccctgtgttg tagcataaag cgttacttca ttccttttca 72120
tggctgaaca tcccattata tggatattcc acattttgtt tatccattca tcagttgatg 72180
ctatctgttg tttccacttt gaggctctta agaataatat gctgctgtga acatttgtgt 72240
acaagttttt tcatgaacat gtttttactt atctgggtat atacctagga gtggagttcc 72300
tgggttatat ggtgactgtt taacataagt gtagaactgt ttttcaaagt gactatacta 72360
tttcacaatc ccaccaacaa tgtatgaggg ttccagtttc cctacatcat cactaacact 72420
tgttttatta tctgcctttt taattctagc catcctagtg ggtatctcat tgtggttttg 72480
agtcgtattt cccttatgac caatgatgct gagtgtcttt ttatgtactt attatccatt 72540
tgcttatctt ccctggagaa ctgtctattc aaatcctttg acatttaaaa aaattagatt 72600
gtcttggggc cgggtgcggt ggctcatgcc tgtaatccca gcactttggg aggctaaggc 72660
aggcagatca cctgaggtca ggagtttgag accagcctgg ccacatgctg aaaccccatc 72720
tctactaaaa atacaaaaat tagctgggta ttggtggcac atgcctgtaa tcccagctac 72780
tctggaggct gaggcaggag aatcacttga acccaggaga cggaggtttc agtcagccga 72840
gattgtgcca ctgcactcca gcctgggcga cagagtgagg ctctgtctca gaaaaataat 72900
aaataaataa ataaataaat attgtcttgg aaatatactt aaattaattg gcctatagtc 72960
ccagctactc aggaggctga ggtgggagga ttgcctgagc ccaggagttt gatgtttcag 73020
tgagctatga ttatgtcact gctctccagc ctgggtgaca gagtgagccc ccatctctga 73080
aaaaaaaaag gaagaaagag gaagaggaag aagaggagga ggagaaggag aagaagaaat 73140
gctcttaagt caatagttct caaacttggt tcacattaaa gtttcctaaa atcctgatgc 73200
tcaggcttta ccctaggcca gttaaatgat aatatcttgg ggtaggaccc aggcaacagt 73260
tttagaaaca aatctccagt tgattctaat gtttgagagc cattgctata gactacatga 73320
ctaagctgat gataccaata taaaaatgtt aaagatttga taatttagaa attatgccag 73380
gtattaaaaa tgggagactt aactcaaatg tgaatcataa aatgcctaat caggtcaaaa 73440
gatagagttg agatttgtaa taaagattga taaactttcc tataatagga agtttcaaac 73500
cacctatagc tagagaaaat gtctggctgt ggttcttgcc tagtgagcag gaattggttt 73560
tatgaggtaa ccatgggaga gccaataaat gtgagtgatc atgacaatta aatctttaag 73620
cccagataat ttatgtcaat tattcaatgt tcattaagga aagtgaaaaa aaatgagtat 73680
tagctaggag aaatggaaag ggaggctttt gaaaggcata aaaagattgg aggctatttt 73740
aagagacttt attggaagca tagaaaaaga gtatctgaga atttttaaaa atccaatcac 73800
ataaaaatgt gacagtcaca gtggttattg tggagggaaa atgacatctc tcaaagaatg 73860
taaaaagctc cccaagggag agcagggagc ccacagagtg tattaggtta agtacaaaat 73920
aggaaaaaag actttaagaa acactttcga agagagtcca aaacacataa agggattatt 73980
taaaatctat taaaaggaag aagctagaat aacagtggga tcttttgctg agaataaggg 74040
ggcacaggga gtgctgaggc accaaaagac aatagacaaa ctaattatgt gcctctgaat 74100
gtattgagaa agataccaga gtgatagcac attcaaattg cctactacga atggatcagt 74160
agtagttaat tcaatggttt tctgtgtttt gcatatttca agtcaggtag gcagaataaa 74220
tactgattaa tcactggaaa ctcttggtgt ttatcttgag atttctgaag gcctccagaa 74280
gaaatttttc tcgtcttgcc tctccctaaa gccactgccc ttgtcctccc tctcctatta 74340
ccaccaaggc tcctaagtgt atagtctacc ctagtcacct cactttctca tctccaattc 74400
attcttcaac ccattcttct aactccattg aaaggtcatt aaatctgact cattgccaaa 74460
gtcattaaat caacagatcg ctttttagac taaattcttt ctagccttta gatatataac 74520
accattaact gtttcttctg ttcttccttt ctgaaacctc ttttcttaac atttattata 74580
tgtgaatgtc ctggttttac ctgtctactt cttgctagct accttcactg gctccagaat 74640
tacttacgta tttctctttt ttgttttttt tttttaaggc tagtcaagtg aagcagtggg 74700
aatggagaag gaacacagaa atctgtaact ggttgtgatc aattaattgt agacactact 74760
gacttcagac aagccttacc tatttaattt tggtaacact ctgggttcca gtctcgattc 74820
acttcttaca ctatatcctt caccttgttt taacctctcc tgtgacatat cctagtgctg 74880
cctctcttcc cattttctaa cttcatggtt gatatagtca tatagatgtt tcacagttta 74940
ttctgatcca gtaaccaaaa ccagattaat atcttaccag caaacttgct cttcctttgt 75000
gtaattcctg tcgtggttaa tagcactacc atccacccgt tctcattctg gattcctttg 75060
tctccctaca catccggcta gttaccaggt tttagatatt taacctctga aatgtctttc 75120
aaatctttct attgtccatc tccattgccc aaccatagtc ttcatttgtt tttcatctgg 75180
actattgcaa tagtccccta actcatcttg ccgacatttt cagctactga tctcttgcca 75240
gcattttttt ttccccaaac acaatctagt tttaaaatac agacttctac tgcctacata 75300
actccttagg taagtattta aggtcttttg tagtctggcc ctaacataaa atatccactt 75360
ttccccttga aattaagttg tgccctggtc gtacatgaga atggccattc cttgagcaca 75420
ccatgcacat tcctcaccat gtctttgttc atgctcttcc ttgtttcaca actcttctca 75480
tttatcacct gacaaactcc tatctatcct ttaagacaaa tttctgtctc tcaaaatgtg 75540
ggccctgggc cagagcagca gtatcacctg ggaacttgtt agaatacaac ttcttggggc 75600
cccactttag actctgttta atccaaaact ttgtgtgata aggaccagca atgtgaattt 75660
taacaagctc accacatgat tctgatgcat tctaaaattt aagaaccact gttctaggga 75720
acaatttttt tatcaatggc catagcactt tacacatacc tgtattactt actgcattat 75780
ttaataacca tgtttactta ttcacttatt tatctggtct gctaagttgt gagtccccag 75840
agtcaaatac aatggtgctg tgttctgaca cctgccatag tgtctagcac ataacaagtg 75900
cttgataaga attcagcata ctaaaatata cccccttccc tccaggattc agtctagcta 75960
gagtaaatag agagggcaag atcaaatggt gtccaaggca tctactctta aaggtcgata 76020
tacaccacac aaaccaaaag cttacacact gacaataaca aatgtcagca aagtaataac 76080
caacgggtac taggcttaat acctgggtga taaaataatc tgtacagcaa actccaatga 76140
tactaattta cctatgtaac aaatatacac ttgtacccct gagcttaaaa taaaagtttt 76200
taaaaaaata aataaagcaa atgtcagcaa ggatgcagag aagctgaatc tctcatacat 76260
tgctgatgta cctactctgg aagacacttt agaagtttct tataaaatta ttccctcact 76320
gtgcgattca gcagtttcac tcctgtgtat ttaccgtaga gaagtaacta tgtatgttca 76380
cacaaaaagc tgtatgcaaa tgttttttag cagctttgtt tgtaatagtc aaaaactgga 76440
aacattaaca atcaaaaaag aaatcaagaa aacaattcca tttgtaatcg catcaaaaaa 76500
tgaaaacttg ggaaaaaatt ttacctaaaa gatgaaagac ctatacactg aaaactataa 76560
aacactgatg aaataaatga ggaaggcaca aatcaatgga aagatatccc atattcatgg 76620
attgaaaaaa tttatattgt taaaatagcc atactaccaa agcaatctac aaatgcaatg 76680
caatcttacc aaaattctga tggtgttttt cacagaaata tgaaaaaaac taaaattctt 76740
atggaaccac aaaagacccc aaatagccaa aacaatcttc accaataaga acaaagctgg 76800
aggtatcacc ctagcctatt taatttcaaa atctactata aagctatagt aatcaaaaca 76860
gcatgatgct ggcataaaaa cagacaaacc aatggaacag aatagagagc ccaaaaataa 76920
atccatccac ttacagtcag ttgatttttg acaaaagtac caagaaaaca caaaagagaa 76980
aggacagcct cttcaataaa tggtgttggg acaactatgt atccacatgc aaaagaatga 77040
aattatgcct gttaccccag cactttggaa ggccaaggtg ggccgatcac ttgaggtcaa 77100
gagtggagac cagcctggcc aacatggtga aaccctgtct ctattaaaaa tacaaaaatt 77160
agccaggtat ggtggcatgc acctgtaatc ccagctactt gggaggctga ggcaggagaa 77220
tcatttggac ccaggaggca gaggttgcag tgagctgaga tcgcaccact gcactccagc 77280
ctgggcaaca gagagagacc ctgtcttaaa aaaaaaaaaa aaaaaagaaa ttggacattg 77340
gacccttata ccatatacaa aaaatccact caaaaatgaa ttaaaagctt aaatgtatga 77400
cctgatactg taaaaactat cagaataaaa cacaggagaa aagctcctgc cattggtccg 77460
ggcaatgatt ttttggttat ggccccaaaa gcacaggcaa caaaacaaaa catagacaaa 77520
tgggattaaa ctaaaaagtt tttgcacagc aatggaaaca ataaacagag tgaagagaca 77580
acctacagaa tgggagaaaa tatttgcaaa ccatacatct ggtaaggggt aaatattcaa 77640
agactataag gaactcaaat caatagcaag aaaacaaata atccaataaa aagtggacaa 77700
aggacctgaa tagacacttc tcaaaagaaa acatacaaat gtccagcagg tatatgaaaa 77760
aattctcaca tcactgatca tcaagaaatg caaattaaaa ccatgagtta ttagctcata 77820
cctgttagaa tggctcttat gaaaaagaga gatagcaaga gttggggagg atttggagaa 77880
aagggaaccc tatacactat ttgtgaggat gtaaattagt acaactatta tggaaaacgg 77940
tatggaggtt cctcaaaaaa ttaaaaatag aactatcata taatcaagca attctacttc 78000
tgggtgtgta tctaaaggaa atgaaatcag tgtatgaaag agatacctgc actcccatgt 78060
tcactgcaac attattccca atagccaaga tatggaacca acctaagtgt tcatttacta 78120
atgaatggat aaagaaaatg tgagatatat atgtacacat acacacacac gatggagtac 78180
tatttagtct taaagaagga aatcctggca tttgcaaaaa catggatgaa cctggaagac 78240
attatgctaa gtgaaataag caagacatag aaaaacaaat actacatgat ctcacttaca 78300
tgtggaatct aaaaaagttg aactcataga agcagagagt agaatggtag ttgccacaga 78360
ctagggtgga ggtggttgac agaaatggag agatgttggt cagatcaaag agcacaaagt 78420
tccaggtagg acagataagt tgtggagagc tatacagtat agtgtctata attagtaata 78480
acgtgttgta tacttgaaga attccaagag agtatgtctt aaatgttctc accataaaaa 78540
aagataagta tgtgcagtga tggatgttga ttaaattgat ttaataattt taattatttc 78600
acaatatata caaatatcaa aataccatgt tgtataccat aaatatataa tatttgtcaa 78660
ttctgcctta ataaagctgg gagaaaaaaa ctggaaaccc aaatatcctt caacaggtga 78720
atggataaac tgtgggacat ccatacaatg gaatactatc tagcaataaa catgggacaa 78780
agtattgata gatgcaacaa cttggatgga gctcaagggc atatgctgcg tgacagatgt 78840
cagtctcaca agcttacaca ctgtaagagt ccagttctat acaacattct taaaagacaa 78900
atttatagtg atggagaatg ggttagtggt tcctaggagt taggttgggg aagcgtgtca 78960
ctataaagga tagcatgaga gagttgtgtt tataagtgtg tatgtgtgat ggaacagttc 79020
actatcctga ttatgatggt ggtttcgtgt ggtgaatttc atagaaatct atatatgtga 79080
taaatttcat aggactacac acacacacac acaaagtgca cataaaaact ggtgaaattt 79140
aaatagagcc tgtagtttat ataatagtat tgcactaatg tcaatttcct gattttgatc 79200
atgaactctg gttatgtacg atgttattgg ggaaagctgg gcgaaggata cacaggaact 79260
ctctgtactg tttttgcaac ctcttgtgag tcttaaataa tttcaaaatg aaaagctttt 79320
gagaaaaata aagcacaggg atttctgaca aaagctaaat tagaaagcac tgcttgacat 79380
aatgctaaaa caggacccag gaagtggaga gctcactgcc tggtggaggt gggaaagggg 79440
taaagggaag tggagattct tgccttgaag aacatttggt agaacgtggg ccaggcctct 79500
caaacaggtc actcctggct tggggaggag ctaatactaa ggtggaaagg gaaatgaaag 79560
cttacttctc atcagcttcc catatgggga agggggccgg aatctctcct caataggcct 79620
ccattttctc aatagggaaa acggagagaa ggggaaaagg gttcctcttt aacaatggtc 79680
acaaaaggtg atgtgtgcag tgaaagatta aatggtataa gaactcaggc tctggaatca 79740
aacccagcct caaatccagt ggcttgattt tctattgaac tttgctatac cctgtttctc 79800
tatttaaaaa caggggtaat gatactactt aactctgaaa gctgattaca ttagattgtc 79860
tatgtagagc acttagcaac cacctagcac atagataatc agtgttggct actcttttta 79920
atactattct atgccattac caattttcta agacgtaaca ataatacact cagatgattc 79980
tgaccataat gtaatttttg attaaagttt cttcaggatc cttcaatgct tccaactcat 80040
aaattatatc agccctcagt ccctatatat gtaaatacaa tttaaattaa aatagttgtt 80100
actttctatt acatgtcttt tatgtgcttt gcactttaaa tacactattt ctaaccttta 80160
tagcatgcag gataaatact attttcccca ttttcagatg aggaaactgc ttcagagtgg 80220
ttaggcaaat ctccaacatc tataaacaac acagtaaacc taggcagtct gatggcaaag 80280
cccaagctct ttccactaca ctgttacctc agtagtaatc cataaaagat gcttaaacac 80340
atacatattg tctattagtt gttcttttta catcacatta catgggcaga ctctacaact 80400
cctgccacag cctggcgcag acacttccag gccattgctg aagccagtgg agacaccaga 80460
cgatgacaga aaccaagaac ccaaagctga ttgtagcaag aattcagtct ggagttcagt 80520
cagtagataa atccgagagg catcatggaa attgtgccaa ggtccaaggt tcaagccagc 80580
agtcagaatc taaaggggca ggcaaaaccc agcaggaggc tctgcaggct ctgtgccccc 80640
cgggagattc atggcttcct ctctgtctcc tcttgttgac actgccggct ataaatgggg 80700
gctttgtgga tcctcagttg aggaggcagg tgaaaattct tggcctacca gcactactac 80760
aggacgttag aaactagggc aggaagaccc tgggtcttca ttaatcagtg tgatgaaaac 80820
aggccccagg cagttgggtc cactagtggg aagtgaaaga acactgaagg aaaccaggag 80880
tcaggacatc tggatttgct gtcccaacat ggtccctatc tggcgataaa acagcatgca 80940
aatttcttca tctaaaaatg aaggaatcag gtcagatcac tgattttcaa actgtgttcc 81000
tcagaaccca aggactccag tcctgctgtg gagagatagg tgggagcaag caaggccttc 81060
ctgtacagca cgcttccttt catctcttcc aagtactgaa ccttctaatt ctaatgattt 81120
attcagcgta acaggcattt aataagtttc tactaggctc ggggccttgt agaaggtgct 81180
gatggggaca aagctgagta aaacccagtc ccaacatcat gaattcctag attctggctt 81240
aatggggaac cattccagca gctgtcactg ttcaggattc ctctcagatt ccaagataca 81300
ccaaggcccg gagttctgcc acagaattga agataagaaa gagaggaaag aggccgagtg 81360
cagtggctca tgcctgtaat ctcaccactt tcggaggccg aggcaggcgg atcacctggg 81420
gtcaggagtt tgagaccagc ctgaccaaca tggagaaacc ctatctctac taaaaataca 81480
aaataaattg ggcatagtgg tgcacacctg taatctcagc tactcgggag actgaggcag 81540
gagaatcgct tgaacctggg aggtggaggt tgcggcgagc cgagatcgcg ccaccgcact 81600
ccagcctggg caacaagagc gaaactccgt ctcaaaaaaa aaagaggaaa gaggaatctt 81660
ccccagtatg gcaggcaatc tttcctgcct caaggagatc aatttacatg tcacctggaa 81720
gcccataata ttctgcttta gcagtgactc cttgtgattg gatgtttcct atggccaatt 81780
gtgcctgtgc ttcatgccct acttaaaatc aggacatctg ctctgccctt ttggaagagc 81840
tacaagtctc ctgccaggaa ttgctcaagg ccttttcctg cagctaaacg gagaaaggaa 81900
gttgaaatca ttgcctcata aattacaaca catgccaggg ttgtaaccta gagtctgagg 81960
ttctaggcga aaagaggatt ttgtgtgtgt gtctagtgtt ttccccacag catttaaaag 82020
ctcatctaaa atatattata attgcatgag atatggcaaa aatacattca gaaactaatt 82080
ttttgaagat aaacaaacaa agcagaatgt gcccataata ttcctaagta aagccacaca 82140
aacttccttt ccagtaaggg tatcctttgg ggctttttcc ccctccttgt caccaactta 82200
tcttgaattt atcactatgc tttttcacta ttgttcctaa acttcagctg ttatataatg 82260
agatagtggg catttagtct tatatccaaa tttccatatt tcagctttta aaatagttgc 82320
aaggatgctt ttaaagttga tcctggccag gagaggtggc tcactcctgt aatcccaact 82380
ctttgggagg ccaagatggg aggattgctt gagtccagga gtttgagacc agcctgggta 82440
acaatgagac cttgtctctg caaaaaaata aaaattaact gggtgtgatg gcatgcactt 82500
gtagtgccag ctacttggga agctgaggtg ggaggattgc ttgagcccag tagataaatg 82560
ttgcagtaag ccaagatcat gccagtacac tccagcctag attagagagt gaaactctgt 82620
ctcagaaatt aaattaaatt aaattaaaaa gttgatccta gcaaactaac accggaacag 82680
aaaacccaac accgcatgtt ctcactcata agtgggagtt gaacaatgag aacacatggt 82740
cacagagagg ggaacatcgc acaccgaggc ctgttggggg ttgggggcaa ggggagggag 82800
agcattagga caaatactta atgcatgtgg ggcttaaaac ctagatgatg ggttgatagg 82860
tgcagcaaac caccatggca catgtataac tatgtaacaa acctgcacat tctgcctatg 82920
tatcccagaa cttaaagtaa aataaaaaaa gaaagaaaaa aaaagttgat ccttaggcct 82980
gtttatagtc caagggagct gtgaatgctg aaatttgtac actgtcaatt tatatgtata 83040
ttcacatatt aatatctata gtacacatag attcaggaat gtagactttt gtcaaatggc 83100
ctagtagata ctgataaaac aacttctaat attaaattaa aattttattc tattttaaag 83160
aaaaagaaca aataagaaaa tcgtctttgc aatgaaaagg tcagaaacca aggatgtggt 83220
gtcctaatat gctgatagca gagattatat ctcctttgcc ttcctatcac tggttcttaa 83280
taccttggca agttagtatt taggaattgt tgaattaatg tttggcacat gaagatcatt 83340
aaagcaataa ctcataaagc atggggaaaa caaggtcatt tgctaaaggg gaatttgggg 83400
gcacgatatt tagcaagtct tctttcacac ttatagctaa atattttgtt tatttgatta 83460
tttgattgat ttgggtgtaa attctattgc acctctggta aaccaagtca gcctgccctt 83520
cctggttaag aaagagagac agaaatgcaa agtgtaacca gcttattaat aagccgagga 83580
tagagaaaag aaatttgtct ctgggctggg agcagtggct catgcctgta atcctagcac 83640
tttgtgaggc cgaggcaggc gggtcacttg agcccaggag tttgagatca gcctgttcaa 83700
catggtgaaa ccccatctct actaaaatta caaatattag gcaaggatgg tggcatgtgc 83760
ctgtaatccc agctacttgg ggtggctgag acacgagaat cgcttgaacc cgggaggtgg 83820
aggttgcagt gagctgagat cgcctcactg cactccagcc tggctgcact ctagcctggg 83880
caacagagtg agactttgtc taaaaaaaaa caaaaaacaa ctgtctctgg cataacttga 83940
gaagggagaa gctagaagag acctttggtt tcatcaggtc caagcactgc taaccattca 84000
gctattctgt gggcagaatg tctttgttct tccaggtgca acttcagcag ctgtgggcct 84060
gaactgacag tgcggggtaa ggatatcact ctctccatgt gaaacaaagc aggactacag 84120
gaaagcaggc tgatttggaa aggccaggcc cacccaggac aagaggcagt gctgagtgtt 84180
tggctcatga caaaacataa tttacaaatt tactggcttc aaggatgtaa aaagttataa 84240
tttactggct tcaagggtgt aaaaaggcct gcttcctagc ctagctgcaa gcagcaactc 84300
agtccatgat cagcagattt tctgaagcct gggggtggga tgcatgttgt taacctctga 84360
tgcagatgtc tgctgagagt ctgtaatctg tgtggtcatg aagatgagat ttcatccatc 84420
aattgcttga caagggctat catcgtatct ctgggcctgc gtggctctca acacacgacg 84480
taagaaacat attggacaaa agcatttcct gggagaattc tccagcaaga attcagccat 84540
tggcaaagaa tctttcaagt ggccctatct cactggagac aagtaaacat atacgcagtg 84600
catatgtgaa tatacactcc ttcaaggtgc tgcactttcc tagaaacaaa aagaatgaga 84660
ggaaaaagct ttacaggcat cctgttagga tgctttctct cgtttatttt taggctcttt 84720
tcagctctgt gctaagaggg gaggcaaagg aagggcttac ccagaatgca aagcttttta 84780
gtgagggttt ggggtgtgca aatttgttaa agtggtgaaa acccagtgtc tatggaagtt 84840
cacagcatcc acagcactca gagcccccca aatatctctg gcccttgtgt tcactaattc 84900
caaggaattc tcagccattc caggggactg tggggatccc cctgaaacca ctacaattac 84960
ccagaatgtg cccctcctaa cacataggca ttgaaccagt tcctaactct cccccaactc 85020
tcacagatct ctagtacttt aagagccata tggcacacat gcttagccct cagccttctg 85080
cctaataggg gagtgctttg ccagggaaaa ataagattag ggaagaggac aaagaaagaa 85140
gaagagaagg agtttccata tccattaatg aattcattca acagatggtt atggaacact 85200
taccattttc caaagaccgt actatggtgt gggttataga ataagaaaca gcctggcttt 85260
tgaggagtag aaactgtccg gtggaactaa cattaaaagg tggtaatata acatgacaat 85320
tgtactgatg cacatagacc ctggggtgtt ttagggacat agaggatggc accaaaccta 85380
gactgagggc atcatccaga cagatacatg ctcttgtttc tgtgagtcct gtgaggtgag 85440
tcactcacaa agaaaatgta aagaaataac tcagaataaa taaaaagata gatggcacag 85500
taagcttggc agattgatgt tggagaacgt cagttttggt ggcaacaatc tgcaaggttg 85560
tctaattttc tcctgcacca ctcggctgcc cggatgcaaa agcagacaat ggattgtggc 85620
tctgatctga gttttattgg gcagatgctg cagaagggct tgtttgaaaa gggaatagga 85680
tgttattgag agaacagttc agatgaccaa ccagggatct gaaattaggt agagacagta 85740
agagagactg ataaactatg aggaagcaaa agaaccaagt gactggaggt ctataggctg 85800
tcaatgtaca aatgtggcag gagtaagcac atgagagggc tggaggatag gatgctcact 85860
catttattcc tcagatgttt attgagtgcc ttcagtgtcc aggtagtgtt ctagttctga 85920
gagtacatca tgcacaatgc tattgggagg agaaaacaat aaataaaatc ataataataa 85980
acaagtaaat tatgtaatat gttaaaaggt aataagtact atggttggat gggggcaggg 86040
gaagagaata gagcagaata agaattcaga attccgagga tagggtataa ttttaaatag 86100
ggttgtcatc atagctctgg ttgagaaggt aacatatgaa cacacaatca ggagagaaag 86160
aggatgagct atgcagatac atgtattgaa atattccagg cagagagaac agccacttca 86220
aagcctcgca gtgtgtgagt gcctggtgtt ttcaaggaaa agcaaggagg ctgtgtggct 86280
ggagtggagt gggcctggag aagatgtaag aaatgaggtc aagaaacaac agggatcgag 86340
tgtgtaggct ttgtagactc tggtaaagac tggctttccc tctgggaaat agagagtcat 86400
tgtggggttt tgagcacaga agtgatgtga tcttatgtct ctttaatgga ttactctagc 86460
tgctatgttg aaaatagact tgagggaagt gccagggtag aagcagggag accagttagg 86520
aggctattgc aataatccaa ataagaaatg caaagtaaga ctttgatcag gtggtggcag 86580
cagaggtggt gagaaggagt tagattctgg atgtatttcg aggatagagc caacaagatt 86640
tatgacagat tggatgtggg tagtgagcaa gagtcaggat gactccaagg tttttggtcc 86700
aggcaaattg aaaggtggag ttgccattat ctgaaatggg gaagaaggtg agcaattgag 86760
agggagactt ggagttaaat tttgaacaga ttgtagtcaa attggtgttg ggatattggt 86820
gtttacaatt cctgaagggg aaccattctg agtgacccta agacccagag tgtaacctgg 86880
ggatgggtgt ctgaagagga ataaagtgaa atcattatga ttgaataatt tagaactctg 86940
gaggctgaaa agctaatgaa atctcctagg atgttctacg aggatggtgg cccaggcacg 87000
agagtaggga acggggtcag gccttatgat ggatacttta aatacaaata gttagaggtc 87060
acactaatat tagcttgagg tgtgcagaat tttaattggg tgcagattag tgtatacatt 87120
agaaataagc aagatattaa aagatcaaat ttgctgaaac acatcagata acattatgat 87180
aaaggtattt ggagttttat ttgagttaga tttacaatcc cattgtagca tggatcaaaa 87240
acagtaagtt gataaagaaa tcagataaat tttcacaatt taaattttaa ttgttttatt 87300
aaaaagcatt ttggaaagac attcatattt ggttttggat aggttaaagc tcagtgatac 87360
catttacatc aatttttata gcattttaga gagcatggtc ttgtgacatc ttaggataag 87420
ttttctgtta gtcacagcat gccaacaagt accttgtgct ccattctctg gccatgtttt 87480
cagactcagt aacttcaaat aaaataaact gccaagttga gaaattaaca tttgataaag 87540
tttttgcaac atcataccat tgagctggtg gatgtggctt aagcatctga attcattaga 87600
gactattgaa atgataatgc agaattatac aggttttgca gatgtagttc aatatttatc 87660
tatatgtatt gaaacctcac ttgaggatag aaaaatcaag caagttcttg tcttacattt 87720
ccactcaata aatgaagagg aagagataat gagaaagcta tataatcctt taaaaaaaaa 87780
attcaccttg tttctgactg acagtaaccc aattcaggct ttttactctt cataaatgga 87840
agacaagtaa cctagatagt actggctatc tataattaaa tatacaatat tgaaatctat 87900
ttgctttgtg gaaattatgt gtttgtggct gattaaaata ttcagctatg taggcttcat 87960
cttttagctc aatagaaaaa tataaatgac attggtgact gaattcctac caacgtggca 88020
aagacattcc ccagacatac ataattcacc tgctgaattg gagatgattc acctttcagt 88080
gacttcacag gtgttaactt ggccaaacaa aaaagggaaa tcatcttgta ttcatctttt 88140
gttccctgag gcaagttttc agtaagattg ctcgggaaaa atatcacaat atacatatat 88200
aagtccatag tatgtctatt tgaataatga attagcacca ctgtctgaga ggtgaaaact 88260
attcaatgta tattttctgg aaaataacta aattgagttc ctcttaacta aatcagaaag 88320
agaaggaatc ctcaatcagg atttcatgta gtactgtatc actcaaagga aaactgattg 88380
tatagtggta ctcaaataaa gtgggtccaa agaaaaatta tgagagaaac gtaccgatca 88440
gtgatctgga ccaaacagac atgtggctgt gaaatccagg cagttgcttg gtgacgaggt 88500
caccatcaga tagtcatggc ttatgtgcag gaatgtgaga atggccatgg ggaggaatgg 88560
cctgggttat gggtcttgca ggagtcccac tgcttgtgcc attgctcaaa cttctgactg 88620
ccctgtgcag ccggtgccag gtcagcagta ctctctgctc tgaatcagtg tcagcactgg 88680
tctctctaat gtagtacctt tcttcaaaaa atgctttgtg aagctgctgg ttagcactgt 88740
tcttacttct gtagttaata ttcaccacat attccccttc ttttgtggag agataaagaa 88800
attaaggaaa atcactctcc ataagtccac aatctgaaga catggaggct gaggaggcag 88860
acctgaatga ataagtggat catatgatag ggctagatct taaatttgga tacaggagac 88920
ttaaggtaaa ccacagaagc ttgttgttta tacatgtagc tcttttgcta aatataaatg 88980
tggcatgtga agattaataa atctgaatgt aatgtacaga atgtactaga acaggaaaaa 89040
attggtgttt actgagagct gaaggttaca tcaaaaatct aaaaagtaat atttttgcat 89100
catcttaaag tttgcaaaca gttttggcac atacatcatc tcatctttgc aataacctgt 89160
ggggtagata caaaagatga tgttattttc attttccaga tgaggaaata ggagcctgtt 89220
tcctggtcag acaggcttag tcagctgtga gtggcagagc tggtgttccc acctgttacc 89280
ctcaacccca gttccattgc tcctaacatg attgtatcct ggataaacat ggtatcaaga 89340
atggagaggc caagcgcggt ggctcacacc ggttatccca acactgtggg aggccgaggt 89400
gggcggatca cctgaggtca ggagttcgag accagcctgg ccaacatggt gaaaccccat 89460
ctctactaaa aatgcaaaaa ttagatgggt gtggtggtgc gtgcctgtaa acccagctac 89520
tggggagact gaggcatgag aatcacttga acctaggagg tggaggttgc agtgagccga 89580
gattgcccca ctgcactcca tcctgcacaa tagaacaaga cactgtctca aaaaaaaaaa 89640
aaaaatggag agtgaaattt gggaggctga ggcaggcaga tcacttgagg tcaggagttt 89700
gagaccagcc tggccatcat ggcaaaagcc tctctctact aaaaatacaa aaatcagcct 89760
ggcgtggtgg tgggcacctg taatcccagc tgctcggggc tgaagcagaa gaattgcttg 89820
aacctaggag gcagaggttg cagtgagcca agatcatacc actacactcc aacctgagca 89880
acagagagag actctgtctc aaaaaaaaaa aaggatggag agtgagagaa aactcagaga 89940
ctttgaaata agaagtgaaa gaggccgggc acagtggctc acacctgtaa tcccagcacc 90000
ttgggagacc gaggcaggca gatcatttga ggtcaggagt gcgagaccag cctggccaac 90060
atggtgaaac ctgtctctac taaaaacaca aaaattagct gggcatggtg gcgggcacct 90120
gtaatcccag ctactcggga ggctgaggca ggagaatcac ttgaaccagg gaggcagagg 90180
ttgtggtgag ccaagatcat gccattgcac ttcagcctgg gtgacagagc aagactctgt 90240
ctcaaaaaaa ttaaaaaaag aagaagaaat gaaagaaact tggcaattga ttgggtgttt 90300
ctgataaaga aacagaagaa ggaaaaggtg attcctaggt ttctaaaacc tggaagaggt 90360
ggacagtgag attataatat aagcagctga tgttggcaac atgcctacta tgtgccaggc 90420
catgtgccaa gcattttgcc atattgcctt attaaatcct tacaactctt tgaaggtaga 90480
tcgcataatt attattctca ttttagaaaa gggtgtgcat gaaagttgct ctcactttta 90540
gaaaaagaaa aaaatcttcc ctccaaaaca aggctaagct caactggatt cactggccta 90600
tgctgacagt acctggggcc tgggacagtg gtttggtgtt cttgtgtgta tggatgtatt 90660
acaatgtcag acacaaagta actaagccgt gctcctggcg gttatgatgc ttgcaaatcc 90720
agcactgcca aactgtttag tgcctcctag gtgctttgcc tgtggttaga acaagcttca 90780
ctaagtggat agttttgcct tggccctgcc tttaaggcag tctgccatgt catcaagaga 90840
cataggtaag aatgctctcc tccttagtta tgatttaaaa ataaaagtat aacaaagtat 90900
aattatcaaa tgactattag tagaaatgtt gcatttatat acactattta gattacaatt 90960
cttaaataca atgtctttcc ttcttgttac ttgtaattaa ttagtatcag tcactgtcca 91020
gtgtgagcct ggcattgccc ttaggttaac cagttcacat cctgaacttc tgttggtgcc 91080
cagggtattt gtctgaaacc ctgattattt acatctccct ctaactttca aatttgtctc 91140
caatctcatc taaaactatt aatacttgag aaaaggcctt tccccaattt cctgcttcta 91200
atccctttat cctctttctt tcttggaaaa gtagaggaaa atggtttaca tatcaaataa 91260
agtaaatagt atatgaaaaa aaaaaaacct ctaagggctc caaactctgt ggatatctac 91320
ctgctggtta tttattcact aagctgcaca tagcaatccc ctagcaacca taaacttcat 91380
gcataaaatc ccaactcttc tccaatacca cctgtttgta ggtagtcatc cttcttttaa 91440
aagacttggg agttatacaa ggaataagtg ccagagttta gttctttgtg aaaataaatt 91500
taaagaaatt ataagttttc acagggctgt aaagatgttt cttcccagtg gtccttcact 91560
ccaaggctgc actggagatt atgctggtga ggaagctttg gtctcgtagg tctttggccc 91620
caaggcaaaa ggtcatggct gtaagtgtct ttcttcctga tcccctctag gattgtgaag 91680
atgtccagtc ccaatctgaa cattgtgacc ttactgggca gttgtctcac ttacagtagc 91740
gcttacctct ttgggattca ggatgtttta gtggggagct caatggaaac tctcattcag 91800
gtaggtgaag ttttaaaatt tggttttgac tataaagttt tgattatttt tttaaaccag 91860
ctgctcccgt gggtggtggt ttcctttatc cttggagtgg gcacttttcg agggaatccc 91920
agaacacttg gtgaggttca ctctgtacct cgtgcgctct gtgggaccca gaccctacag 91980
atcagagtgt gtggagaact gataaaggtt cctcttgtga ctcttctgtc cccttccacc 92040
catagacaag actgtccatg ctgtgcattg ggacctccct tgtgtttggc cccattctgg 92100
gaaagagctg gcgactctac aaggtgttta cccaaagggt cccggacaag agagtggtga 92160
gtaggcagca agtacacaat gcttgactgt agatggtagc ttcagcattg gttaacagct 92220
agagaagctc atgcacatta ctgagcctag cccctttcag gacatccaaa gttcctgttt 92280
ctcattccaa accctggaat catgcagcct cataaggcct caggtctgga aggctgtgga 92340
tcagtgctgt tgaagatagg gcttcaaacg tgggctctgg ttcctatgta ccccaggccc 92400
tgtggggaca tgtgagctgg ccaatacctg gcaccagtgt gaggcagaac aagataccca 92460
gagactgttg tttggcacag gtgcgagctg gaagtgaagg gaggaagagt gattacagag 92520
aaactatagc aagtaagtag ttatttcctt ccctggagtc cagttctttt ctatgtagaa 92580
ggcagttctc tgtactgaga aggatgtgcc caaagcagtg agcaaggaag agcagataga 92640
atcaactcta agttatgtag cagccagatc accgacatgt ccctggtatc agtcatcaac 92700
ttaaccacat ttccccattt tatcaggttg tctgatgaga ctgctcaaac ctcaattcct 92760
gaccattatc ctcattgggt ataggccctg cccagaccca atatatcatt cagttggtgt 92820
ttacttctct ggaatgatgg gaatttattt tagcaaatgt tattgaatca tggtgcatac 92880
ttaccaaaag ctcagctgtg agcaaccata cctatgaaga agattgccta aaaggacaaa 92940
aactgcattc atccctcaag aacaccaatt tcttttttaa acagctttac tgaagtataa 93000
ctgacatgca gtgaactgca catatttaaa gcatatgatt tgataaattg tgacatggat 93060
atacaaccaa gaaacatggt gcataatgaa catatccctc atcttcaaaa gcttccttgc 93120
aaccctttgt tatctccctc ccctgtccaa tccttatatc ccttgttcct atcctcagaa 93180
aatcattgat ttgctgtcac tgtagatgag tttgcatttt ccagagtttt acataaatgg 93240
aaccatgcag tatggactct gttttctctg gcttatttta ctcacataat tgtttttatg 93300
aatattatag ttatttatct atgttgtgtg catcaatagt tatttctttg ttattgctga 93360
gtagtattac aatgcataga cacaatttgc ttatctgtag atggatgttt gggttatcgc 93420
cagttgtggc gattaaaatt aaagctgcta tgaacattcg tgtacaaagt ctttgtttag 93480
acataggctt ttatttctct tgggtgaaaa cctaagagta tggttggatc atatggtaag 93540
tgtatattta actttttaag taacagtcag actgtttttc gaagtggttg taccattctg 93600
catttccacc agcaatgtat gagagtccat ttcctccaca ttcttggcaa catttgattt 93660
gatcagtctt tttcatttta ggcattctaa taggtatgtg tggtagtatc tcattatgct 93720
ttcaaatttg catttctcta atgcagtatt gagcatttct tcacttgctt atttgccatc 93780
catacacctt ctttggcaaa ctttctgttc aaatcttcca cccatttttt ttttttttct 93840
gagacagagt ttcattcttt cgcccaggcc ggagtgcagt ggtgtgatct tggctcactg 93900
caacctctgc cttctgcttt ccagcaattc tcctgcctca gcctcccaag tagctgggat 93960
tacaggcacc caccagcaca cccggctaat ttttgtattt ttagtagaga tggggtttca 94020
tcatgttgac caggctggtc tcgaactcct gacctcgtga tccgcctacc ttggcctccc 94080
aaagtgctgg gattataggc atgagccacc acacccagcc tcactcattt ttaaattgga 94140
ttttttgttg tcttattatt gagttttgtg agttcttttt atattctgga tacaaaccct 94200
ttatcagatg tatgatttgc aaagattttc ttccagtttg ttcttttgtt ccttttactt 94260
tcatttactt cagaatgtct ttcaaagata agacatttct cattctgatg aagttgaatt 94320
taccaatgtg ttctttgttt ttaggtttct tgtttatttg tttgtttgtt tttgtatttt 94380
tagtagagac ggggctttac catgttggcc aggctggtct caaactcctg gcctcaagtg 94440
attcaccagc ctcagcctcc caaagttcca ggattacagg catgagccac cacacccggc 94500
cccaatgtgt tcttttatgg atcatgtttt tggtattata tttaagaaat ttttgcctaa 94560
cttaaggccc caaaaggttt tctcatgtgt ttacttccag aaattttaga gttttagctt 94620
tgacatttag gcctatgatc ggtatatggt atgatgtatt gattgaattt tagtttttta 94680
catatagaca tttgattatt ccaacatcat ttgttgaaaa gattgtcctt tcttcactga 94740
attacctttg tgcctttgtt aaatcagttg tccataagtg tgtagatcta tttctggacc 94800
ctccattctg tctcactgat gtgtctatct caacagcaat gccatattac cctgattact 94860
gtagctttat actaaatctt gaaatcaggt agtattagtt ctttgacttt cttcttctct 94920
ttcaatgctg ttttggctaa tctgggtcct ttgaatgccc atgtgaattt ttgaatcagt 94980
tcactgattt ctacaaaaat tcttttggga ttatgttgaa tctaatagat caaattatgg 95040
agaattggct tcttactaat gttgtgtcct ttgacccatg aacccattta tttaggtctt 95100
taatttttcc catcattttt ttgtactttt caatattgct ctttcacatc tttcatcaaa 95160
cttatttcta gggattttat atttttatgc tattttatat gttactattt ttttaaattt 95220
cactttccag ttgtttgttg ctaataaata gaaatataat tattattatt attttttttt 95280
gagatggagt ctcactctgt cgcttaggct ggagtgcagt ggtgcgatct cggcttaccg 95340
caacctccgc ctcccgggtt caagcaattc tcctacctca gcctcccaag tagctaggat 95400
tacaggtgcc tgctaccaca cctggttagt ttttgtattt ttagtagaga tgaggtttta 95460
ccgttttggc caggttggtc tcaaactccc aacctcagat gatctgcctt ccttggcctc 95520
ccgaagttct gggattacag gcattagcca ccatgcctgg ccacagaaat ataattaatt 95580
tttatatgct tagcttgtat actgcaacct tgctaaacta catgttagtt ctagcagctt 95640
ttttatagag tctatcagat tttctacaaa gatgatcata tcagcagtga ataaagataa 95700
tttatttcca atctcttgtc tgattgcact ggctagatac aatagtacaa tctgaataga 95760
agtggtgaga gcagatatat ttgttattct tgatcctatg gggaaaacag tcaaaactaa 95820
gaatgatatt agcagtagtt ttattgtaaa ttccatttat ccagttgggg cagtactatt 95880
ctattcttat tttgctgaga gttttaatca agaactgatg ttgggttttg tcaaaagctt 95940
tttctgggtc tattgagatg atcatacagt ttttcttttc ttagtttatt cgcatggtgg 96000
attatgttaa atggtttttt ttttaaaccc ttacacaata gactttattt tttagagtag 96060
ttttaagtta acataaaaat tgagcagaag gtacagaggt tttacatata cagtctttcc 96120
ccacacatgc atagcctctc ccattatcaa tattccccat cagagtatat acttattaca 96180
attgatggaa ctacattaat acgtcattat cacccagagt ctgtacttga cattagggtt 96240
cacttttggt gttgtacatt ttatgggtct ggacaaatgt gcaatgacat gtatctacca 96300
ttacagtatc atacagagta gttttactgc cctaaaaatc ctctatgctt ctgctcatta 96360
tctctttctc tccccatatg ttaaatgatt tagggtgtca aaccaacctt ccatccctgg 96420
gattagcttc atttggtcat gctacattat cctcttcata tattgttgga ctcagtttta 96480
taaaaacttt gtttagaatt tgtacattca tgtttttaat acatattgct ctgtggttgc 96540
cttgtaatat atttttctag ttttggtatc agggtaatgt tggctttata aaatgagttg 96600
ggaactattc ccttcttttc aatttcagga ataatttcta tagaatagca taattggcac 96660
tcatgtataa gtaccttaca atagtatgct tccttttatc cccattccta tctttgctgt 96720
tacatgttat aggccccatg caattctttt gtttaataaa tcaattatct ttaaaaatat 96780
tttatttttt tatttttaag acccaggaca acatgctgaa ttttgttatt ttctttaatg 96840
atatttaaat aatgaaaact aatcatgtat ttttctgttt agttaccatt tccagtgttc 96900
ttaatttcct gtatagatcc acatttttat ctcatattat tttcctttgc ctgaaggata 96960
tctaacattc cagtgtgggt gtgctactac tgaattcttt cagcttttga ttatctgaaa 97020
aagtctttat tttgccttca tttctgaaag atatattact gagtatagaa ttctagactg 97080
aaattttctt ttcttcttct agtactttca agatgttcct gcactgtctt ctcacttggc 97140
cttgtatctg atgagaagtg tcaggtttat tttatgtcta cacaaaatgt gtctttcttc 97200
actgcttgct ttgagtagtt tccctttatc actggttttg aacagtttga ttaggcaatt 97260
ggtttgtttt taattttaca aacaccttga atcacgtaac tggttgtgct tcttttcact 97320
ggttgtcaaa agctcagatc cacatttctt ctgctccaat tagtaaatgc tattatatat 97380
acactcttca tctgagcctt catcataatt ccctttattt tctctcttcc cggttgttaa 97440
atattttaat cctatcacag tatatatttt tctcaatttt atttttgtag tcacaaacta 97500
acacattctc ttcatcctaa gtcaaatacg gatggtccct gacataaaac agttcaactt 97560
acagtttttc tattttacaa tggtgtgaaa gcaatccaca ttcagtagaa accatactta 97620
aaatacccat acaaccactc tgtttttcac tttcagcaca gtagtcaata cattttatga 97680
gatattcaac acttcattat aaattaaatt aagctttgtt ttagatgatt ttgcccaggt 97740
gtaggctaat ataagtgttc tgagcacatt aaaggtaggc taggttaagc tgcaatgttt 97800
ggtagcctag gtgtattaaa tgcatttttg acttatgata ttttcaactt atgatgggtt 97860
tatccggaca taaccccatc ataagtcaag atcataagtc aatctgtaat tcatatgtat 97920
ataatgaaaa tgctaatgat tcttcctgca tctctgagtc ccaccctctc agttaatagt 97980
tattaacatt gtggtgtgac attcatatct atgtgcttat ataaacatat agaaataata 98040
gtttatttat tttataaaac accttgagtc ctttgtggga aaaggtagga tatgaagaag 98100
ttaaacaaat ggaaatgtgt aatgctaata atgatatcag catagaagtc attgtaaatg 98160
tttggtgtct gtttcatttt tgatagctac atttgaagct ccttgggagg gctgaccttg 98220
gagcatatag ctgagagcac atgggatact ctagcccctc tgtcatttag ccagtcaaca 98280
aggagaagtt ttgaccttga ctcttttgca gattatcaaa gacctgcagt tgctggggtt 98340
ggtggcagcc ctgttgatgg ctgatgtgat cctgctcatg acgtgggtgc tgactgatcc 98400
catccagtgc ctccagattc tcagtgtcag tatgacggtg aggggccaaa tccctagaga 98460
atctcatccc caaactggac tgacctctgt ggatacacag gagtcatcct tgcaacaaga 98520
agataaagga ctccaagagg agggagagtc aggagttgtg gcttccatgt aattcttgcc 98580
ctagtctgct gccactccca ctgctcctcc tgcccgagtg tctctttgtg ggcatacaat 98640
gagatatcag catgctggaa tctgcctggc agttctgcca cttccacatt atcaataatt 98700
aaaactttca gctatcggca gttaccttcc cctaattgta gaggtggagg tagtagttta 98760
aggtggcctt tggagtcagt caaccctggt tcaaatccca gctctaccaa gctcaccagt 98820
tgtgtgacct tgggaaagtt atgtaacctc tctaagtctg tttcctaatt ggtaaaattg 98880
agataataat actacctatc tcatagggtt gtggcaaaga ttaaatgaaa caatgtaggt 98940
aaaagactta accatgtcca gtacatacta ttcaattaac aagaagtatg gccgggcacg 99000
gtggctcacg cctgtaatcc cagcattttg ggaggctgag gcaggtagct cacttgaggt 99060
gaggagtttg agaccagcct ggccaacatg atgaaaccat gtctctacca aaaatacaaa 99120
aattagccag gcgtggtggc acatgcctgt aatcccagct acttgggaag ctgaggcagg 99180
agaatctctt gaacccagga agcagaggtt gcagtgagct gagattgcac cactgcactc 99240
cagcctgggt gacagagtga gaccctgcca aaaaaaaaaa aaaattatta tatatctcca 99300
gcctcacgag gggctgagga atacagtgga atcatggaat cgtgacactg caagattaat 99360
gtttaaggat tcaatgattt gcaaaaagca ggtgcataat gaaatagttt atagttttgt 99420
tgaggcacta atttgattgg ggtagcaaag cacataaatg aggggtaagc cctagtgtca 99480
ccaagcacac agctgttagc ccaactttat catctcttct cctaacacgt agtcactctc 99540
atttaggttc tagtggagtc acctaaatgc tgcagttttt acatactgag ggggtatcat 99600
gtactctaga agaattcatg ctccagcatg ttcacaaaga tctgctttgt gttcctggta 99660
attgtgggca cctccagttc tgactctgtg tcccttctag gtgacaggga aagacgtgtc 99720
ctgcacttcg accagcaccc acttctgtgc ttcccggtat tccgatgttt ggattgctct 99780
catttgggga tgcaaggttg gtaaccacat ctgatatggt ctctgtcacc aagaaaatgg 99840
atatgaagag ggaattacag gaattaacga ggtgatgtct gcaaagaatc ttgaactcag 99900
aggagacctc tgttgatgca taaacttcaa agccatgact gtttttactt ttctatttgt 99960
atttgtttgg gggagaccct ccaactcttt agactccctc attcagtcct cccccaaatc 100020
atctggaatt cacccactgt ttctcctatt tattggtctg gtttcttaat tgatttgaca 100080
ataccagttt tcccttcatc ttccctgcaa gaggaattat gaggagaaat ttgacccagc 100140
tttatttgtt ctcctaagtg cccttattat gtctcttgtg ttttcttcaa gatttgggcg 100200
aaggtgtcct ggtgcctttc acccacctga ctttctccct ctggttggaa gcaagactgg 100260
ctctgagaca gatggcagca ttcacagggc cctttgaggg gttccacctg tctcacagtg 100320
tctcccatac tgccccaaat ctctcaccat tagactcatt tgtctctgtt agatgggcaa 100380
aagtagaata ttatttccag aaggtagagg atacctgcat ggagcactga ggatggtcct 100440
cagaacagga cagctggttt tcagcttagg gagacagaga actggtgctg aggggtacag 100500
ggcagtcctg attccataaa caagcaagtc ctgcctgaca gcagactacc tgttgactat 100560
cagggcagag agttctggtt gactgattac tggcagagga aaaggaggag tttttgtaga 100620
aataagtacc ctttaagggt aaactctggc cgggcacagt ggctcacacc tgtaatccca 100680
gcactttggg aggctgaggt gggtggatca cttaaggtca ggagttcgag accagcctgg 100740
ccaaacatgg tgaaactctg cctctactaa aaatatagaa attagctggg tgtggtggta 100800
tgcacctata atcccagcta cttgggaggc ttgaggcagg agaatcactt gaacctggga 100860
ggcagaggtt acagtgagcc aagattgcgc cactgcactc catcctgggc aacagagcga 100920
gactctatct caataaaaaa aaaaaggggg ggtaaacttt acccacttca ccactaagaa 100980
agtattagaa gttgttgctt gtgaggaaca ggtttagggg taggccagac tagggcaggg 101040
aaacattcct ttttaactat gtgcaaatat tactttgaca gaaatatttt ttaaaagaag 101100
actctaggaa gtgaacagct cttgatctcc agaatcttgc taatggttaa aaaaggagct 101160
ttagttgtga cagatcaggg tttgaatctg actccgcccc tggctagcca accctgagcc 101220
tcatttaacc tctctgagcc tcagtttcca aattttaaaa tgcggatgat gataatatcc 101280
cctcagaact gttctgtctc taaagagtta atgcatgtta agagttttca gccgctcctg 101340
gtccatagca agagctcaat aaatgttaga tattattatt actattcttc cactgccccc 101400
tagacacttc tggaaaatac attgcctctg ttggttcctt gagtccctgt agaagagtgt 101460
gtcctcccta gcccagaaag ccagcacttc ccccatagct acttactttg tgactcaatt 101520
tgatttattt tctccattgc cttttatata ctctcatttc cattctattt tactgtaata 101580
tctttctgta ggaaaaagaa ggaaaaggat ggagcatcag gaaacttact gagccagacc 101640
ccatagactc cctggtcagt gagaagctcc tcaggaggac cccaatctcc acattgagtc 101700
ctaggacccc tgctctctgt caactgcccc ctaccccaca cttctcagca gttaaggcca 101760
gtgatatgca aggatcaaat atgactcact cagacaccag ccaggaatgt atagacactt 101820
gattcacacc catttcccct ttaacaagaa ttttaatgga attaaaaact tttagtggaa 101880
tcatatctga acatttcaaa atcacagaat taatttcatt tgccttttat taaattagca 101940
atgatccaac tctgctgaat accacctgat ggcgtcagtt acccaaaagt tgggcttccc 102000
tggtctcctg acttatgtgt cctctagtca ttgaagatct cagggtggcc acatttggcc 102060
ttcaggcccc atttgggaca ctgggcatta ggggaacctg gaaggtatct cttccatgct 102120
gactccttcc cttctggcac agccagttct ccaaaatatg ttctttagtg tcacccatga 102180
aggtggagtt gaccacgtca tatgatttga gggtcaccag caggtgtcct gctgatacct 102240
gactttattt tcattattag ttctccctct gaatcccaca gtcccacccc cacctcgtct 102300
cccatggcat cttcacgttc tgagtcatca acatgaacat ttttaggctg ggcgcagtgg 102360
ctcatgccgg taatcccagc actttgggag gctaaggcgg ttggatcacc tgaggtcagg 102420
agtttgagac cagcctgacc aacatggtga aaccccatct ctactaaaaa tacaaaatta 102480
gctcagcatg gtggcacaag cctgtaatcc cagctactcg ggggctgaga caggagaatc 102540
gcttgaaccc gggagacgga ggttgcagtg agcagagatc atgccattgc acttcagcct 102600
gggcaacaag agcgaaactc catctcaaaa aaaaaaaaaa agaagatttt tgtgcttacc 102660
ttaaatctac ctaccagacc aagtgttaaa agccaggacc atgacttctt tgtgtcacta 102720
ttttctgccc tacacgtact atggcactgc acacatagtc agaaaggtga acctaattga 102780
atctatgtgt tatgtattat tgactaaagc tttgatttct gtatgaatgc agctcctgtg 102840
gagggggcag cactttaagg tgctatgagt tattttctcc ttagtacaaa tgacaactct 102900
gagagcaggt ttatattcat aggaaagaga acagaatagg gccctgggtt ccttgtaggg 102960
gagcaagaaa tgtcacaaaa agggtgagaa ctatagatgg agctttcgct gtctgtgcct 103020
gccccacagt cttgcctggg tcccagcctg cctttgttct cccctttttt tacccttcat 103080
ctcccataaa cactcactgg catggagccg ctgctagcct gtagagatcc tttgtgtaaa 103140
ttttttgaag gcccatccct tctagtcaga tgcagtcttg caggtgcaag gcttggcaag 103200
cagatggtgc ctttgggcaa attagagaaa agagcccctt cctatgggca ctaccctggc 103260
tgtggcacat gacttgacaa gcagatcaga ggtcactttc agcttccctg tgcaccctca 103320
gctttgagca gggcaacacc agacaatggc tgtggtagca ctcactatca gaggttctgt 103380
gggcccactg tcctccaagt gcccaacagc tctttctgta gggatactaa cccacccaca 103440
tgatcctgtc ctatgccttg tctcagaaga gtcttattta atggctgact tgctgacttc 103500
tgataaacta attctcagca aaggagagga aaataacatt tattaagtat ctagtaggta 103560
taaggggctg ccctgagggt tttcttatgt gatatcttag taaatcctca tagcagtcct 103620
taaggtaggt attattatcc taattttaca gatgaggaaa ttggttgcaa acctactgct 103680
cattgacctc ttgttccact tctctgagcc tccgtcacct cttcaccccc cagggtctgc 103740
tcctgctgta tggtgcctac ctggctggcc tgactggcca tgtcagctcc cctcctgtga 103800
atcagtcctt aaccatcatg gtgggggtca acctccttgt actggctgct gggctgcttt 103860
ttgtagtcac cagatacttg cattcctggc ccaacctggt ctttggactc acatctggag 103920
ggatctttgt ttgtacaact acaatcaact gcttcatctt cattccccag gtatggattt 103980
tgcagggctg gtcctcttag tcactctaga gtttttcact gacaaattgc tcattttgtt 104040
ttctactgat acctttccat gccacttatt ggagagtcag aaagcagaca ggggatccta 104100
gtgagctggt tgcctttgtc ctttctcact gtcctggtca gcaaggggga caaggcagag 104160
tggtccaagc agtggtggca gcccctgttt gcactcttcc acacctgtgg tgcctgtccc 104220
ttgggggggc tgcctcgcag tcctgctttt ccatccaccc tctggtctgc tgcactcgtt 104280
ccccatcctc ccctcatttc catcatgtta ttactatttc tttcactagc ctgggagcaa 104340
ggaaccttta tatttttcca attggggatt gcagactcac aggaaaaaat ccatttagat 104400
ggaactttat gatttaaagt gctttctctt tctttttatt ggaggaaaat acagaacatt 104460
tctctgcttt ttacaataag gagaggtaga aactaaataa aaatatgttt catattatgg 104520
ggattttaaa aaatcaaatg agggaggaag acagaagcag aaatagccag atagcaaaga 104580
agaaaggtag tcagagggaa cagagaagga atcctaggct cagaaagcaa ggggatgtgg 104640
gattgttcat gctacaccct ggggaccatc aagccacata tatctaggtt aatgaacttg 104700
gcactaggta ctttcttgtt tccctcctag ttctcctttt cttccctctg agacctccct 104760
catcccactc ctccttcaag accctgtcct gattcccatt gcaacttcca gttgactgta 104820
aactaattcc tcatgatgga gctaactgat aatgtaagtg ttggctgatg gcacgttaca 104880
gtgtatttgt gaaagggaag agtgcacttt gggtcatgat ggtatgacat gggcatagcc 104940
ctgttacgat tcttctctat cacaaatcct cattacagta ctcaacagaa tacataaata 105000
tggaaaaatc tgcagcagca gcactagaaa cgatggatgg ctattgcctc tgtgccagaa 105060
actggaggaa tttttgccaa atcttaatgc cgtaaaaact ggaatgaagg aagccattta 105120
gagctgaggc ttgtttgtct gggatgaggc agaaatgggc tctgagaagc aaggactgtt 105180
tctccctggg agaccggggg cgggggcggg gtgggtgggc aggggtaagg gtaggcaggt 105240
gccttttggg aagcccaccc cttaggccct gcagccaata ttgttggatt ggtagcgatc 105300
aacaatgcag agaactggtg ctgaagggta caaggcagtc ctgattccat aaacaagcaa 105360
gccctgcctg acagcagcct acctgttgac tgtcagggcg gagaggcctg gttgactgat 105420
tactggcaga ggaaaaggag gagtttttgt agaaataagt accctttaag ggtaaactct 105480
ggccaggcac agtggctcac acctgtaatc ccagcacttg gtgaggctga ggtaggcgta 105540
tcacttgagg ttaggagttc gagaccagcc tggccaacat ggtgaaactc tgtctctact 105600
aaaaatatga aaattagctg ggcatggtgg tgcacgccta taatcccagc tactcgggag 105660
gctgaggcag gaaaatcact tgaacccggg aggcagaggt tgcagtgagc cgagattgcg 105720
ccactgccct ccagcctggg caacagagct gctaacccct ttcttccttg cttgcctgca 105780
ctatagagac agcaacagct agactcttct tttgccagct tcccatagag ataggagtgc 105840
ctatatgaca ccattttgaa cactagaggt tttctgagaa gcttctgaga aagcttttgc 105900
tttcctgaaa aaggttataa gcatggctaa catcaccctt tttaccttct tcctgccttg 105960
aatgtatgtg attcctagag ctatggcagc tctcttgtga acataaggaa aagactaaga 106020
gaatatagtt ataatactag gaagatacag ctctttccat gtaagattat aaattctgga 106080
ggaaatgatc tatgaaggga atctgcagtt cacaagaaga ggactacaaa tgtctaaaga 106140
tttagagaag ctgccttcct ctggagtaga agtgtttaga agataccgga cttgtcaata 106200
gaattcaaag gatattgtct cttctcaact aaagcaaact atcatgaaaa aaagctaatc 106260
ttaataaaat attgaataag gattaaaaat atggtattaa atttaaaatc ccaatagaag 106320
cattgactgg gcaattagac actacaaaat attgaattag tgaattactt taaggaaaca 106380
gaaaataagg aaacaaatga gagactagat aagaaaatat ggaaaatggc cagatgcagt 106440
acctcatgcc tgtaatccca gcattttggg aggccgatgt gagcggatca cctgaggtca 106500
ggagttcgaa accagcctga ccaacatggt gaaaccccat ctctactaaa aatacaaaaa 106560
ttagctgggc gttgtggcat ccatctgtaa tcccagctac tagggagact gaggcaggag 106620
aatcgcctga acccaggagg cagaggttgc agtgagccaa gatcacgcca ttgcactcca 106680
gcctgggcaa caagagcgaa aatctgtctc aaaaaataaa ataaaaagaa aaaaataaaa 106740
tatggaaaac atctaggaat acaattgaga gctgatagga gtctctgaaa gagaacaaaa 106800
taatttgggg cagaagtcat tatcaaagag ctatcagagg aaaatgtttc tgaacaaaca 106860
aagccttggt cagaaaactg aatgaattgg caatctccat gatggcgccc tgcttactgc 106920
tcctctctcc atcctcacct ctcaccactg cccccttgca tcgtaagcct cagccacatc 106980
acttcccctt tgcctggtgt ttgagtcctc agcagctagg acaattgtga catctgggta 107040
ctctacacac aaaaatgcag aatgaagtgc tgcttgaaat ctgccttcca ggttttcact 107100
aagcaacaaa cacttgattt gttgaattgg gaatggaaat ggaatgatta tgaggtacag 107160
gaattgggtg gatggactgc actggccttg ctttccttct atctcactcc ctctttccct 107220
cctagctttc ttaagcttcc tttctcttac tctgtctttc ctcttccatt ttctcccttg 107280
tgtttttttt ttttctcctc tggaactaac tgaccatgat gtgaaactaa aaaatatatt 107340
ttgtagtctg ttgtatttta ggtttagatg gtaagtagtt ctttttcaaa atataaaaga 107400
aactgaggtt tgttaggttt ctgtgtgttt ccctctggct ccgaggtctt tggtagaaga 107460
acgattctcc ctgtgatact tgcactgtgt attcctagaa gataatttgg gaaagtaatt 107520
tgagtaaatt tgggaaagtg ggtgagggga actatctggg taagggttgg gggttgcagc 107580
aaaacggggt tccttcttgc cagtgagctt tcagacatga ctgtgatggg aggagtttgt 107640
gaaagcaaag gcacagatac ccccagggca gcgaggcagc gccagagagc gggtgaaatg 107700
gatgacatta ctaaggagac aaggggccca agaagccttc tttacacagg cactcaggaa 107760
atgcctgagt gtttatgcca agcactgagg tcatcactag aagtcagcca gccgctgctg 107820
ttctgacctg aatatgaccc atcccccagc cctctgctcc ctcagagagg caggcaggtc 107880
ctaaggtagg acattgtttt ctctctcctc taaccccgaa agcatttcat ctgctcctcc 107940
ctgaagatgt gcaggccttt ctaatctgcc ttataattat atgtatatgt cccagcaccc 108000
ctactagacc agtgagcatt ttaaagaaag cttccttcat ttgttcatgc atgcatccat 108060
ccatccactt attaactgct gggtacatgc acttaaacac agagtccgcc tctaggtcta 108120
gtggggagca aacatgaaag gaattatcat acatgtgtta agagctttga gaaaggcctt 108180
ccccagccca tctgagaact cagtggcacc ttctcagaaa atgaggctgg gcatggtggc 108240
tcatgcttat aatcccagca cttttcaagg ctgaggcggg tagatcgctt gagcccaaga 108300
gttcgagagc aacctggtca acatggtgaa acctggtctc tgcaaaaaat gcaaaaattg 108360
gctagacgtg gtggctcacg cctgtaattc cagcagtttg ggaggacaag gcgggcagat 108420
cacgtgaagt caggagtttg agaccagcct ggccaacatg gtaaaacccc gtctctacta 108480
aaaatacaaa aaattagctg ggtgtggtgg cgggcgcctg taatccagct acttgggagg 108540
ctgaggcagg agagttgctt aaaccgggag acaagggttg cagtgagccg agattgtgcc 108600
attgcactcc agccagagac agagtgagac tgtctcaaaa aatataaagc aaaaattagc 108660
caggcatggt ggtgcatgcc tctggtccca gctacccagg aggctgaagt aggaggatca 108720
cctgagccca ggaggttgag gctgcagtga gctgtgattg tgccactgca ctccagacag 108780
agtaagaccc tgtctcaaaa aaaaaaaaaa agaaggaagg aagggagaga gggagggagg 108840
gaaggaggga ggtaggaagg aaggaaggaa ggaagatgag gtgttcgagc tcagtcttga 108900
aggaaacata agagttcatt gaagagatgg gggaaagtag gtggcatttc tgatggaata 108960
acatcatgac cagaggcagg gaggctagaa agagagtagc gtatgtttgg agcaccatgg 109020
tctttgttat ttttgaagca caaatggaaa ccagggggag aatgacagga ctggggagag 109080
acacacctgg ggagcttctg aggccctgct ggaccctgtt aaagagttga catttagtcc 109140
caccatatta gtttcccact gctgctataa caaattccca caagcttagt ggcttaaaat 109200
aatacaagtt tattatctta aaattttgga ggtcagaaat ctgaaatagg tcttatttgg 109260
ctaaacttaa ggtgtcagga agtctgtatt ccctccagag atgcaagggg agaatctgtt 109320
tccttgtctt tttcagcttc tagaggccgt ctgcattctt gtgcttattg tcccctcctc 109380
caccttctaa gccagccagg ttcaaatctg ccagaagaga ttcaaatctt tctctctctc 109440
gcccctgttt ccattgtcac atctccttct ccaactctgg ctctcctccc tccctcctat 109500
aaggattctt gtgattacat tgggcccact tggataaccc agaataatca cccctcttga 109560
aatccttaat tacatttgca aagtcccttt tgccacataa ggtcacatat tcacaggctc 109620
caggaattag gatgagagag aacatctttg agaagccact gttcagtctg ccacaccccc 109680
atagcccaga ggctcagaaa accagaatct gcctgtcctt ctggaggaag gcagaggaga 109740
ggccctgaat tgtgaaattc atagctggat tccagaaacc ctgaagggtt gagccttaag 109800
gagtatcttc acaaatgagg aatgaagggc tagagtaatc aaggggtatc ttggctccac 109860
ttggccaatt tagagacagg aagaccaaaa gccctgggag ggcccttacg ccagtgctga 109920
gctgctcctc tgccagccct gcagagaggc ctcagtctgg gagtgctggg ggagatgaag 109980
gaaaagctgt actgcagcac tgccagggtc agtgtgagga gaataaccct aggaggtctg 110040
attcatccac ccaaggccac agatgacctt gtgttgttgg ctccagtagc tcccaagtag 110100
gatggtgagc tgagagcatc ctttcgtggg gagggggcct tcaagaaggg catctgagag 110160
gggaggtacc aggcctgacc caacacaggt cacacagact cctggtgcga tgatggactc 110220
atgatgagtc agcagaggac ccaagaggac ttgggtgata atatcaattt cagtggcatt 110280
gaaattgatg gcaggattca gaatcctatc tgagatttac aaaatttggt ttacactcca 110340
tggtcggagc ttaacaaatg tttgatggat gagtaaagaa atcccaggat ccctttgagg 110400
ctacccatag acactgcagc atcatttcta gaatcaaggt cccagggtcc ccagtgtcca 110460
tcactaggac acttagttat ggggattcct gagaggaaaa cagaggcctt ccccactgtg 110520
gcttcctgcg tcactcacat tactgtcatt cggtgggtca gcagtacccc acagactcag 110580
gcagaggctc ctgtttctat gttcagcttc attcctgtta aactaaacca gcccatgctt 110640
ctgcagagtg ttcctcaaga ccagtttctc ctgaagagct ttccctggac tgccaccgtt 110700
aacagtctct ctcttcatca actgagtgag gacacagaca tggcacagtg tcctgcttac 110760
agctgttgtt ctgctgctaa gtggctgtgt aagcttagac acaacactcc tgagcctttc 110820
ctagtttgtc aaagaaactg ggtgatgagc tagagcatcc tgatgtgact agggggcttc 110880
cctcaaaggc tctctgagcc ttgattattg acttgggtta gaagttcacc caaaggaact 110940
gaattttcaa tagcagcaag cacattgtta ctgaacaaat gaaaaataat taaatagctg 111000
catgcaacga gaaagtgtca tttgaaactt atagtgttca ggttgcttaa ccccaggata 111060
gctcctaact ctggctttag aatgtggtgg tagaagatac ttcagctctg gttttctttg 111120
accagtttgg caatgggtag gcagatgggc taaggctgtt ctattttatc tacctgtcct 111180
attcttcctt tggaaatttg tgtttgtttt tagggtgttt tgggtttttg tttttttttt 111240
ttaagattgg gtctcactct gccacccagg ctagagtaca gtatcacaac aatagctcac 111300
agtagcctga aactcttgag ctcaagtgat cctcccactt cagcctcctg agtagctggg 111360
attataggag tgagccattg cacccagccc tttggcattt taaaaattat ataaccttaa 111420
cattttgtat aattacaaaa ggtaaggacc ttttgtcatt accatctttg agccctccag 111480
agcaaagtac attttaagga gagaatagct tgcgcatgtg tgtatctatg atagtgtcat 111540
tccttggtgt ttatgagaaa gagtgagaga gtgtgtttct ggatgtgtaa ttaaataaat 111600
aacatgtgtt cttttatcta acagctgaag caatggaagg catttgaaga ggaaaaccaa 111660
acaatcagac gcatggccaa atatttcagc actcccaaca aaagcttcca tacccagtat 111720
ggtgaggagg agaactgcca cccgagggga gagaaaagct ccatggagag gctcctcaca 111780
gaagtaagct ctgcccctgc ctggaagatt ccctgtaaag gatccaatca tgcatcggtg 111840
gcccccaagg ctcttattgc tgatgttctc ttttcctctc attctcccac ttctcttaac 111900
agcaagcaaa acctcaccat ttccaccgtg acacgcatct acttcattca ttcagtggac 111960
agatgtataa tgagtcactc ctatgtgcca ggcattgtgc cagtgaacaa tgaacaaaag 112020
catggttcct accctcacag agctcacagt ctagtggaag aaatagagat tcattcatca 112080
agcaaacatg taattataca ttgtcataag aattatgaaa gaaaaatcag agtggtaaga 112140
cagaataatg tgtggtaagg gcaagaaaac ataacttaga ccagtcagaa aagactcatt 112200
gagctgaggg ctgaaggtta agtacaaatt agccaggcaa agagtacagg gaaaagtatt 112260
ccaagctgcg ggaacagcat tgtaaaggcc ctgaaatgtg gtggacacta gcttccctgt 112320
gatacatttt ctctcttttt tttttttttt tttttttttg agatgaggcc tcactctgtt 112380
tcccaggctg gagtgcactg gtaccatctt ggctcactga aacctccacc tcctaggttc 112440
aagcaattct cctgcctcag cctcccaagt agctgggact acaggcaccc accaccatgc 112500
tcagctaact tttgtatttt tagtagagac ggggtttcac catgttaccc aggttagtct 112560
caaactcctg acctcaagtg atctacctgc cctggcctcc cagggtgctg ggatcacagg 112620
tgtgagccgc cgcgcctggc ctcattttct ctttttacat agagtagtgt cttcatgtcc 112680
aagatctcct ggggtcctta ctgtctttcc caggtactgg ctacagatct caatcagccc 112740
atcatcccag aaagtccagg catgtctaca gatggagaag gggactaaac aagggcttct 112800
gaatgtgatt gtagcaccaa gggagaatga ggcagctccc ccgggcttct ttcttctgta 112860
tttgagccag agttggcccc tctcccagac ttgggcagtg tgatgcaggc atgaagaaag 112920
cacgtggaaa ggtttgaagg cttcgttgac tcaggaagaa ggcacagggc ccaggggagt 112980
tagtcagtat tttgacacta actgaattac attccatatt ttttcagttt agaacctatc 113040
tcaggaggtg ttatttggaa aactgggctt tttttttagg actgctgcct aggtattaat 113100
agtccctgat gagaggatag tgtggtgggg acctagaaaa cacaacagat gaagggactc 113160
agcacaccca ggcacccacc gttcatgccc ctctatggtt ctggaccatt tttgtccatc 113220
agagtaacac ctctccattt ctttactatt aagtatttca aagccagatt tctttccacc 113280
tggcaaggga gtaatattgc ctttgatact ctgtgaagtc ttcaaataag catttttttt 113340
tcctggctac acagaaggcc agaaacttgg ctagaacagc caggatagtt ttcattcaca 113400
gtcagctgat gctggaacag ccaagtggac tgactcttta gccttatggt aatttgcaac 113460
gtgctgtttg tacttctgcc atgctaccct gtttcccacg cagggactca atctgctata 113520
tccaaaaaga tgctttgagt ctgcagagga agcccttcaa tgggcacagg tgcacaagtg 113580
gtaagaagct ggcctcccca gtgcacgcta cacctggaat ctctttccca gaacaggcca 113640
gagaacaagc ggccagtcct agggcccggt ggcaggtgtc aggaggttcc agcatctgca 113700
tccccagctc cagcattgcc cgttagagaa acatgagtat ctctcctggc tcaacatatg 113760
tacagacctt gactctggcc catggtgtgc agtgccttcc tgtgcaggcc ccactccccc 113820
actcaggcct tcctcttact ttcccgtgat ctgggcagcc ccatcttctc acacttttcc 113880
ctcttgcctc tatagccagg ggtcccccca gaagctgttt cggacagcat ctatcacatc 113940
tatcactgac ttccctgtct aagagaaggc cagcagacag aaccttccac aaggctgaag 114000
tgctttcctc atacactctg cagccaagta aacaaaccta ttacttttgt tacctgaacc 114060
atagaaacaa gaggctaatt ccatgtctcc ttatggcctg ccccctgtga aacatgcagg 114120
tggatgtttt gcttccctca atatgccaaa aataataatt aataagctca ttgaagtgca 114180
gctgccgtgg taggtcagat ttcagtctca taatggcagt gcctcacacc acacctctaa 114240
ttagtatgca gccatggtaa aaacagagtc ccacttcttt ttctggaaga aggaaatttt 114300
ctgtttaggt tgatgtttct aaatctgtca ccagccagct tcttcccaac tccatgttta 114360
tagtatcttt ctatactcaa aggagtttat agataaggca caaaaagaca gcactcagat 114420
ttcacccacg ggagtagttg ccatctgccg atgggtcctt cctaactctg tgaggctata 114480
gaggcctcca gaagcccaca tgagaatgtg cacgatgggc ttcaggagga gaggctggtg 114540
gaggagggag ttgaggtccc cccatgagat cctcagagag atgcctggca cagcccagga 114600
tcacaaacac ctgagtgttt ccctattgct catccattct gcccctgaca agtccttgag 114660
tcatctgcac tcacccagca acacccagac ctcaccactc tgcgggcaga gggaagggag 114720
ggaggacagg cacacatgtg ctcagctgaa agtctcttct accttactca ccagtccctc 114780
actggccctg gactctcttc tgatggtaaa agaagtatac tcaaccaggg tgaaactagc 114840
aataccaact atcagaaaaa tcaccttccc aattctacaa ggggagcagt gcatctgctt 114900
ggagagttgc tagtcagaat attggactat tttgcttaag ctactgctcc cttaaaggat 114960
catttctagg caactctccc atgtaaacct gagatgaaac cacaggttca ctctataact 115020
agtagtccta gttagctgtt atggacggta taactaggca atttgtattg gttatcctaa 115080
cacagggaac atccttttgt ttctagggca taataaatgg aggtccaaat gctcatgccc 115140
agctcctaaa gatgatagta acaaagaggt agcattttgg tgttcagaca agcactttct 115200
agaacatttg cttacattat tgccttccca gaaccctcga ccccatgtca tctgccccaa 115260
gtccagacgt tccctgtgaa tatctcctcc ctgctctgcc tttgaggatc agaagtttcc 115320
agagatggac acacagtctg aactagagaa tcagctgctg caccacagaa agatgtctgg 115380
gctgcagtcg ttccctgcaa cccactgcca acactcctac tcctacttca tgccccacaa 115440
tctcgcagtt aggacaggca cacctctgca gctctcacct gccagccctc tccggcacaa 115500
cttgtttacc agctaacatc cagcgagtag gcaggtcagt agcagaactg ccccaggctc 115560
cttcgtctcc tgggctccat tctagggctg ctgaatcaag ctagcagggg cttaagccca 115620
acagtccttt catttctttg tgcttcttca atagttctga tgcttgcact cctttaggtg 115680
agtggttccc aacatttttg gcaccaggga ccacttccgt ggaagacagt ttttccacag 115740
atagtggtgg ggggatggtt tcgggatgaa actgttccac ctcagatcat cagacattag 115800
cttctcataa ggagtgtgca gcctagaccc ctcacatgtg cagttcacaa tagggtttgc 115860
gcttctgtga gaatctaatg tctcagctga tctgatggaa gctcaggtgg taatgcttcc 115920
tcacccaccg ctcacctcct gctgtgcggc ctggttccta acagtccatg gactagtact 115980
ggtccgtggc ccaggagttg gggacccctg ctttaggtga aatcaacagc tgatattgcc 116040
acatggtagc tttggccact cactcccaga ggtccagcct agggaggtga taacaccaac 116100
ctgagattct ctttggcccc tctcagctcc aatcttattt gattgtcaca gaaatctcca 116160
cccttctcct tgttcttccc attttctagg ctgtttagta agaggcaaaa tacttgttct 116220
cctacttctt catcccctgg agatatgctt cacatttatc taaatttttg caaaagtgtg 116280
ataaactcca agtgggacca ttccaaacat tattcagctc atacctgcgg agtggcctga 116340
ccctctcagt tctgggaaag gtgagagggc gctgcagtgg ccagcaggca ctcagactgg 116400
gcctccttgc tcttcataag caatgccgca cagtgtgggg atgtaaggag aagaccaaga 116460
taatgacaat aaatcatggt tggcctttat tgagcaccgt ttatgtcagt tattgtgcta 116520
gcactttaca tgcatcaact catttcactg gagggaggca cctccttaga acctgaggtc 116580
accagccaat acactggaag aactgagatt tcagccaagg ttctttgaaa gccacacctt 116640
ctccaccatg gtgggcacta tggaaccctc ggcggcatct tttgttgatg gttttgcttt 116700
tattttacag aaaaatgctg tgattgaaag cctgcaggaa caagtaaaca acgccaaaga 116760
gaagattgtg aggctgatgt cagctgagtg cacctatgac ctcccagagg gggctgcccc 116820
acctgcctct tccccgaaca aggacgtcca ggcggtagcc tcggtccaca ccctggcagc 116880
tgctcagggg ccttcgggtc acctctctga ctttcagaat gatcctggca tggctgcccg 116940
ggattcccag tgcacttcag ggccctcctc atatgcacaa agccttgagg ggcctgggaa 117000
ggactccagc ttctccccag ggaaggagga gaagatatct gactcaaaag acttttctga 117060
tcatttagac tcaggttgta gccagaagcc atggactgag caaagcctgg gtccagaaag 117120
aggagaccaa gtccccatga accccagcca gagtctccta ccaganagag gcggctcaga 117180
tccccagaga cagaggcatc tggagaactc agaggacccc ccagagcggc ggtcacgggt 117240
tagttcagta atcagggaga aacttcagga ggtcttacaa gatctgggcc tgggccctga 117300
ggcttccctc tccaccgccc cctcttgtca tcagcaaacc tggaagaaca gtgctgcctt 117360
cagcccccaa aagatgcccc tctccaagga gctcggcttt agcccttaca tggtgaggag 117420
aaggcgggca gctcagcggg cccgctcaca ctttcctggc tctgcaccct catctgtggg 117480
gcatcgggca aacaggactg ttcctggggc acacagcagg ctacatgtgc agaatgggga 117540
cagccccagc ctggccccac aaactactga ttccagagta cgaagacctt cttccaggaa 117600
gccttcacta ccttcagatc ctcaagacag accaggtacc ctggagggca gcaaacaaag 117660
ccagacagag cccgaggggg ctagagggag caaagcagcc tttcttcgcc agccttctgg 117720
ttctggccgg gccccaagtc ctgctgcccc atgcctctcc aaagcctcac ctgacttgcc 117780
tgaacagtgg cagctgtggc ccccagtgcc ctcaggctgt gcctccctgt cttctcaaca 117840
cagctatttt gatactgagt ccagcagctc agatgagttc ttctgccgct gccaccggcc 117900
ctactgtgaa atctgcttcc agagctcttc tgactctagt gacagtggca catcagacac 117960
tgaccctgag cctactgggg ggctggcttc ctgggaaaag ctgtgggccc gctccaagcc 118020
tattgtgaac ttcaaagatg acttgaaacc cacgctggtg tgaaaagcaa cagagctggt 118080
ctagacacag aggtcagtcc aagagaagct gtaccaaggc ccacaggaga agagccaatt 118140
tctggtcttt ggggaacaga ttagtgccct gcatttgacc agcccatacc atgtttcagc 118200
taggctcact gtgttacttt gagtacttct tgatctataa aaagagaggc attgcctgtc 118260
ctgttactac ctcgcagcct tactataaaa gactccagtt gagtgactat gaaagacact 118320
gactccttgg ataaaaggtg ctgaatgaac acataggatt ttctgtccag gtcagcctac 118380
attctgtaaa actcttaata tattcagatg gatggctgaa tggacagaca gatggagaga 118440
tgcatgggaa atttctgtag aacttgaggt gtggactgtg acccatcaaa ctggcctttt 118500
ggtggacaga cctaccagga agataagtct cctacatcct tgggcctccc actcctggaa 118560
ggcagtggtt ttatttctgc tgaatgttgt gaacagcacc tccctagatt ccagcttctg 118620
gccagaccca gctcagagcc acccctacac cactatttct tgatggtgtc tttccaccat 118680
tatggcactt taccctcctc tctgagacag atctccatgc gcccgcaggc ttcccagatc 118740
tctcccctgg gatcggatgt acctgaggtc ctgactgtcc ccactgtccc cttgtcctgt 118800
ggctcatcct cgattcaccc actgatgcag ttttgtactg cggggaggca cacaccagca 118860
atttctgttg gggtatggga gaacctgttg gtcaagagtg cttttggttc cattggggtt 118920
acatgactac caacagacac ataaacctgg aagccaaatg gagaaataaa aaggaagaca 118980
cgagggacac gaaaacagga aagaaaacag gatttgaata tttcacttga gtccagcata 119040
gtacttggca atatcatatt tttgtgattc cttttgataa ccctgtgaag tagacacttt 119100
catttttaca gacaaggatt atgaggctta gagaaatgag gtagtttccc gcaacatcac 119160
actgctggac agagatgtac acacagctcc tgggactcaa gtaggtgggt tttcccaggg 119220
acacatggct tcatgtgttc ttctgggaat ggcaggtgac gcttggcaga cgagacaaca 119280
aagcaaggct catgtaagaa agctgggatg tgctccccta tagtccagaa taatagacct 119340
gggtcctcac ctcaggaaac gggcctccac ttcctcactg ccaaaggcca cactggcacc 119400
tcccaaggga gctggggagc tggtgaagga tgagtgcgag gaactcagcc accaccagag 119460
ccacagggag agcacacctg ggtccactgt gcttattgct gagctggctg tcatgtccag 119520
gctgtcccct gccccgagtc ctgtgtatac atctgtgggt gtgcacatgt ttgcatgaag 119580
gaattcaggc cttattaaat attctcagag gggggcattt ggctctaaat gtatcatcaa 119640
tttatcatgg aatcttgggg gctgctgaca cccctggact ctccaggcac tgaaccatga 119700
ggccctcctg gaagcacagc ttcttctatc atctactttt aaacaggaat ttcctaattt 119760
attctgtgca tgggtttgca gtttcttgtg ctgtgtgtgt gctgtccaag tggtaccata 119820
ataaaagaga aatgactccc gagaggagtc ttttcagaaa ctgtaatctg gggctggcca 119880
ggaggggccc ggagaaggct gacccaccca aagaagggga accagagaag ccatcagagc 119940
tgctgccggg ctaccctggg tcccagtgta ccttctacca aagttccatt tgaacagatt 120000
cttctgtgtt ctccctaaga agcctcttat cccagaaaca ctccctcaat ggacatagga 120060
aaccctggag accctggact cttcctgccc ctgggggtcc tgtggctggg ctccccctcc 120120
tgcagctccc ttcctcccag catgccacca ctagcagccc accattcatt catgtggact 120180
ctaaatctgg caatccttct agccttctca ctctgtctgc ttctagaacc ttagtcccac 120240
catccccgcc cttctacatc tccatccttc tgtttagaat tttttttccc actttgtgcc 120300
cttgtgaatt attcatcctt caaggctcag gtggagcata cattctttct tcaacctttc 120360
ccagccatcc ccaaagaaag ctgattgatt ccctagttaa ataaggaagg atgggctgga 120420
agcagtggct cacgtctgta atcccagcac 120450
<210> 11
<211> 120438
<212> DNA
<213> Homo sapien
<220>
<223> E529D GPR156 isomer GAT genomic DNA
<220>
<221> variation
<222> (117154) .. (117154)
<223> n is a, g, t, or c
<400> 11
ggggaccgtg ggcgtcctgc acatagcagc gggcttggcg cttctcggcg gtccgacgct 60
gatgaggtga gcacagcgac cttaaggatc cacaaaactt caaacactta attattaagt 120
gaaagtggaa agggggaggg gctttctctc cctttccaga atctgggcag tttgtttgga 180
accggtaaag aaactctcat aggaacttga ggtgagcagg ggtcacgcat cagggatgcg 240
agtggcaatt tcagtggaag agacgggaga gtactgtaat ttggtgtgaa gatggggccg 300
tgggttttct gctgaataag cgaccggctg tgctgaaaat gagagatccc gaaacagttt 360
cccaccgcct gtagactttc cagagtctcc tcacgccgaa tctgctttgc agggcatgtt 420
cacccccagg gtgtagagtg gcgggcacga tgggctcccc catggagatt gcaaagtcct 480
gaaaagggac aattgtattg cactgcgtct gttgaactgc cttgcttctg ggcatgaggg 540
agtcacctgg aagctgcaac atccttgtac cctggcaagc agccctttcc aagttagctc 600
tgtcagaaac tagaggcctc taggtagaac tcaaggtatc catgtactcg tgaagaatac 660
aaaccttgag gtttttaaaa tcgaattttg ttaagatttc aggatagaaa tctgggaaga 720
gaagtcatgg catggcataa cttacccctt tgttagtttt ctaggtacat gcatgcttga 780
attagaggta aatgatgccc tagcctatca taaaatgtct ttcctggtgt agttctttaa 840
accagaatat ggaggataac attacatttt tgcatcctag ataaaaggga aagattttca 900
gatggggctt acacagcggg agaaattgtt gatatagttg tattaggcag caaggcctgc 960
aaagaaaaac ttctttttct ccaccagtgg ctgaattctg cacagaatgt ctcctcgcag 1020
tctgggtagc agcccggctt gcaaaaacag tgcttctttc attgctgcag gtggggcaaa 1080
tgcgcttgcg gataaatggc tggggaagcg tttgcttaca ggttaaggca atttgagtct 1140
ggagaataaa gtgctttagc aggctgtgct tgagttaggt gtcccttgtg aggaatagag 1200
gtggctttct ggtccccatt ttgccagcct aattcccctt cagggacact actgtctctg 1260
gaatgttccc tctgtttccc cttctcttcc acccccagct tttagcttct ccccattccc 1320
cagtaaagtc tagaattgag cctggtcaga gtcaaagttc tgatagccta gggatataga 1380
acttcaagcc tggtgaaggc agaaatgaga cctaggagag acccaagatg ggtgagatga 1440
aacaactttc agcctagaag gctctcaaaa gagtggaaaa ataatgattg agggaaacag 1500
attctctgga aaggagaata ggtgcttaag tgtttgtttt cagctgaggg ttttaatatt 1560
tccatttttg ttgtttaacc ataagggaat ttccattata gggtaggagg aggatgaggc 1620
cttctctgaa aactgcatcc ttctccttga atttgcattt tattccattc ttatgtaggt 1680
ttcagagatt aattggggga agggggagag aggaaagaag ccagaggctc tgacatgctg 1740
cagaaacagt gcaacgtgga ctgacttggg ctgcaaaggt ggatttgggg gttgaaagaa 1800
atgttctaca tttagttgaa aaaaaaaaat cagagccttt attttgcaaa ggtcttgaga 1860
atcagaacat tcatgtttag ttgctgatga attttgcctg ataaaggatg caaatcacta 1920
tctcaccttt ttttctccag tactttatta tgaaaaattt tagacataca gagatgtttt 1980
ctacctctca ttttataaac ttattatctt aaaacaaact tgttaataaa aatcagtgtt 2040
tagaatccag acatatgtga tctggtcctg gacagagctt gaatcagaag gtgtttcaaa 2100
tatagatgtg tgaaggatat taacatttta agaaaaaaat atggatctta ttcttctgac 2160
tttcccataa gaatcttgag cagacccctt aactgccttc tttttcccat tcttaaaatg 2220
tcagtcagtt ggatgatatt actctcctgc ttaacaccct ccaatggctt cccctcacac 2280
tgtgaataac attcaactct ccaccagggc ttgtgatttg gtctggtgcc ctcatattct 2340
atggccgtcc tcttgcttac catcgtcctt gctcttccct ctgcctgaac actcttcctt 2400
cagacactgc cactgcttct tttctcagct cattccagtt tcttttcata ctctccagaa 2460
tgatggccac ctgatctaaa acagcctgtg gtcactccct gtcttctgac cctgctttat 2520
ccttcttcat ggcacttagc actccctgac actatatagt atatgtgttt ccttgttaat 2580
tgggcatgtt ccccactcta atgtaaactc catcaagaca aggaattttt ttgtcttatt 2640
tatggctgtg ttcctatttg gtatattatg agcaattaat aaataactgt tggattaatt 2700
aggtaactaa attacacaaa taaggcattg actcccataa gggtggcaga acccttggta 2760
aaatactaga agtcctttga ggtaattcat aattcaagtt aatcaatatt tgataggtaa 2820
atgatgaccc tggagatcag tggcctcttt tatcctcaca gcacttctca gctgaatcct 2880
atgctaatag ctggccagtt ttgacaaacc cacatcccaa acaagacata aaatatttca 2940
gtcacagaac ttttcctcac gtctctttct agtcacctcc accccacaga agcagcaaac 3000
cttgttctga tttctaatat catagattag tgttgctggt tcctgaattt catataactg 3060
cagttacaca gtatgcactc ttgtgtttgg cttctttttg ccctacacaa tgtctgtgat 3120
attcatctgt gccattgtgt gtatcagtag ttcatttctt ttttttccaa ggtagtattt 3180
attgtatgaa tattgaccat gtgtttatct gttctcttgt tgatagatac ttggttgttg 3240
ccagtttgtg gcaattttga acaaagctgc tgtgaaccta taaagggtct gcctcatctt 3300
gagtcttctc tactttatat gaaaatcttc cttgtgccac caatgcagag agaagtatgg 3360
caaggttatg ggggctgtga ctgatgtagc agcttgcatg taccccagcc agtgctctct 3420
ctagacagct ctgctgggag ctgacctgct tcccacttta gagggaaagc acttggaaaa 3480
tgagtgtcta acaaattagc gagccctcca gtgcactctt aagtgcttta aatccttgaa 3540
agagacactg tggaatgcct gctgccatca ctgttgtatt tccctcctcc tctcagcttc 3600
cccatcccag cacaagttga ctctaatcag cttctgagca ttatgctact gaggggttta 3660
aacattcatg agcaagagtc ttgttcagag cctgataaaa tattcatgtg tttccatggg 3720
gcattggttt ccatctagac ttctcaaggc atttttctga gatgcatgtc gtaattgtga 3780
agaactcaga cagtgatgga tgatacggcc ctgtgttatt aaaccctacc acacagagca 3840
ccttgctttc tagggatgga gaagaatgag cacacagaaa aattgacatt aatcctgtct 3900
agatcaagag aaaggctaca tgtactgata aaaatggctt gagtaaagag gggcctgtta 3960
atatagtacc aacaaaggta tgaatccata gaggagagtg aaaagaactt gttaaaatga 4020
gaggaatgct gggatgcagt cattccaagt ggaagaatgg gggaatcagc attgtaaaat 4080
gcacagttcc tttgacactc atgtggacga ggttcatatg agacaactgt gctgagtgct 4140
gtaattatca caacctgcta tgagaggatg agagtagaag tggaggctag gcagggtttc 4200
caagtagagc cagagagcta ttccaagagg agtcaacatt tctcttcaag gaagaagtgg 4260
ctttgagtca ggttctgaag gaggtgtgcc tctttgactg gcagctgcgg tgtggaaggg 4320
actttccaga gagacagaat agcatgatag agtgagggcc aaagtgccgg tgtggtgtga 4380
gtaaggagag aaggtgggtg gatgggggtc agggcagggt tgcagcaaga cataaagcag 4440
gagagctaaa ggccagctta tgaaggccac aggaggatgg acttcagtct gtttgctgga 4500
gggccgtgta acttttggcc agagattggg ttacattttg aggagttctt gggaagtata 4560
tccaccctag gcaaggcctt gaggtatgtt tatgtccaag gcatttccag aatattctgc 4620
tgtgtccaga acactatgaa gactctacgt ggtctactct aagagaggta aaccagagga 4680
ggtcagatat actcagtata ctcctgggac tgaccagaaa caggcctcac caggcacctc 4740
tctgccccca gcacacaaac actcagaata ttctgagtca gattgaatcc acagcattcc 4800
ctagacttct tcatgaccac tttgcctcag ctgggggagt tgcaatgatc taagtatccc 4860
cttatcacct gaatctgggc caggatacct cagacatggg ttgccaggca actgagggct 4920
aagtgatgca gctggccaat catccccaca aagcccaggt ctgctttgac caggccatcg 4980
ggctgtgacc agagaggcaa cttggggggt tgaggtcatg cagactgatg acttgtggac 5040
acaactgcca ggccccttcc atatgtcttc ttcctttggg ttgcagattt ctattcaaaa 5100
atgcctcagg atgttgattt tttaacccat aataaaaata gtgaagtagg gaggagtgtt 5160
aaacatgtca gtcatctata ccttatgttg tcattgggaa gaaataactg tggaaacaat 5220
tgtcccggga aagtcagtct tcagtcttgc agtgaggagc tttgcatatg tggagattag 5280
ctagaaagct ctggagttct gatggtgaga agggatttct tgggtcaagg ataggaaagg 5340
gcaagggagg accttcatga ttctccccag ggctttgctg gttggaattg ctcttctgct 5400
gccatgggta gcatggggtt tcagtgactg aaaacaccca ggaaagtatg ctctgggtct 5460
tcatgttgcc atctgcctac actggaatgt cagaccatca gtcagcactg ccagctctcc 5520
atcttgattt tctaagagtt attgagaaaa ccttgaaagg gaaggcagaa gtgggtgtct 5580
taactaggga aatgccaagg tcctaaaggt gtggtctagg ttgaaggtgt ggtaagggcc 5640
tgaagtcatt ggtctggcag tacttcagac caataaagtc tttcttggct cttatctaaa 5700
atattcctga ttttctgtgt gaggtggaat ctctcaagtg ctgcattaat cagtcttttg 5760
gctgaacagg taaatagggt gcatgcttaa ttgagtgcct tttctttttt taaagtttca 5820
gcttttattt tacattaaga ggatacatgt gtaggattgt tcatgggtaa attggaccca 5880
ggcataagca cagtacccaa taggtagttt ttcaacccat gccccctccc tcccttcccc 5940
ctgtagtagt ctgcagtatc tatctttcct gcgtttatgt ccatgtgtgc tcagtgttta 6000
gctcccactt ataagtgaga acatgtggta ttttgttttc tgttcctgca ttaattcact 6060
taggataggc ctccaactgc atccacgttg ctgcaaagga catgatttca ttatttttta 6120
tcctatggtg tttatgtagc acattttctt catccagtac actgttgatg agtgcctagg 6180
ttgattccac atctttgcta ttgtgaatag tgctgtgatg cacatatgca agcatgtgta 6240
tttatggtgg aatgatttat atttctttga atatataccc agtaatggga ttgctgggtc 6300
aaaggtagct ctgtatttaa gttttttgag aaatctccaa actgctttcc acagtggttg 6360
tactaattta cattcccacc aacaatgtat aaatgttccc ttttcttcac agccttgcca 6420
gcatctgttg ttttttgact ttttaataat agctattctt actggtgtga gatggtatct 6480
tattgtggtt ttatttgcat ttctctgatg attagtgatg ctgagcatgt tttcatgtct 6540
attggccaca cttgtatgcc ttcttttaag aagtgtcttt tcatgtcttc tgcccacttt 6600
ttaatggagt tatttgattt ttgcctgttg atttaagttt cttatatatt ctggatatta 6660
gacctttgtc agatgcatag tttgtgaata ttttctccca tgctgtaggt tgtttactct 6720
tttgatggtt tctcttgctg tgcagaagat ctttagttta attaggtccc acttgtcaat 6780
ttttgttttt gttgcagttc tttctgggga cttggccata aattctttgc caaggccaat 6840
gttgataagg gtatttccta ggttttcttc tatgattttt atagtttgag gtcttatgtt 6900
aaatctttaa tccattttta gttagttttt gtatatggtg aaaggtaagg gtctagtttc 6960
attcttctgc atatggctac cagttatccc agcaccattt attgaatagg gagtcctttc 7020
tccattgctt gttttttgtc agccatgttg aagatcagat ggttgtaagc gtgcagcctt 7080
atttctgaat tttctattat gttccattag tctatgtgtc tctttttgta ccagtaccac 7140
cctgttttgg ctactctagc aaattctttg gaattaagga aaatagggac acaatttatg 7200
aagacctctg ggatgtagcc aaagcaatgt taagaggaaa gtttatagcc gtaaatgcct 7260
tcatcaagaa gctggaaaga tctcacatta acaatgtaac tttgcattta aaggaactat 7320
gaaaaaagga caaaccaacc ccaactctag cagaagaaaa gaaataacta aaattaaaga 7380
aaaacttaat gaaattgaga tgcaacaatc catatgaaag atcagtgaaa ccaagaatag 7440
gctatttgaa aaaataaata agattgatag actgctagct aggttaacaa agcgggagga 7500
gacagtgaga gagagagaga ggatccaaat aagtacaata gaaataacaa agatgacatt 7560
acaactgatc ctatagaaat acaaaagatc cttggagaaa actatgaaca gctctatgca 7620
cacaaattag aaaatctaga agaaatcaat caattcctgg aaacaatctc ttgagattga 7680
atcggagaga ttgaagtcct gaatagacca acatcaaact ctgaaattgc atcagtaaaa 7740
caaacaaaca aacaaaaaaa acccttccaa ccataaaaag ccctggacca gatagattca 7800
cagccacatt ctatgagaca tgcaaagaag aactagtacc aatcctacta aaacttacag 7860
aaaatagagg agcagggact cctccccaat tcatcccatg aagccagcat cagcctaata 7920
cccaaatctg gcagagatat gatgaagaga tatgattttt gtgtctatgt tcagaccaat 7980
atccctgatg aacatagaca caaaaatcct caacaaaata ctagcaaacc aaatttagca 8040
gaacatcaaa aagttaattc accatgatca agcaggcatt attcctggga tgcatggttg 8100
gttcaacata cacaaatcat agtgagtcac catgtaaaca gaattaaaag caaaaaccgt 8160
tatgatcatc tgtgtcatct caatagacac agaaaaagct tttgataaaa tctaacatct 8220
cttcatgata aaaactctca acaaactagg catcgaagga acatacctca aaataataag 8280
ggccatccct gataaaccta cagctaacat catactgaat gggcaaaagc tggaaccatt 8340
ccccttgaga actggaacaa ggcaagaatg cccactctca ccactgctat tcaaggtagt 8400
gctagaagtc ccagccagca cagtctggca atagaaagaa ataaaaggca tccaaataag 8460
aaaagaagaa gatgaactat ctccctttgc tgacgatata attctatact tagaacaccc 8520
caaagactgt tccaaaaggt tactagaatt gaaaaatgat tttagcaagg tttcaggata 8580
caaaatcaat gtacgaaaat cagtagcatt tctaaacacc aataacgtcc aggctgagag 8640
tcaaatcaag aacatgatcc catttacgac agctgcaaag aaaaggaaat acctaggaat 8700
atagcaaacc aaaaaggtga aagagctctg caaggagaac tacaatacac tgctgaaaaa 8760
aagttagaaa caacacaaat aaatgaaaaa atatcccatg ctcatggatt agaaggatca 8820
atatcattaa aatggtcata ctgcccaaag caatgtatac attcaatgct attcctatca 8880
aactactaac atcagtcttt acagaattag aaaaaactat tctaaaactc atatggaacc 8940
caaaaagagc ctgaatagcc aaagcaagcc tgagcaaaaa aaaaaaaaca aagccggagc 9000
atcacactac ctgagtgcct tttctgaaca gatatttcaa tgattctgtg attattcatg 9060
agccagtgat ggctgcctgc ttttggatgc tgctaggata aatgcagaag atcagagtga 9120
agagggagag ggaagcataa cagcagcaga gaggaaaagg gaagagagta gtgacgtgct 9180
gaaatcgcag agattgtggg tacccagtta tctacaagtg agaaacaggg ataaaagaag 9240
atcaaataac tacccatggg aattttacat gcaaatattg ctgacttcca aggcagctgt 9300
gaggagaaag gaagggagga gacacaaagg cagctgtcac agtcaatccg aggaatatta 9360
ataaaaactt gacacatgaa aacacatggc cgtatcacaa cagcctgggt cccagcaagg 9420
atgtctattc aaacccctct ttcacatttc cttatattca ttcacagtat taggtatttt 9480
gcaagacatt catttgcact tgcaaagata cacaaatgca gagtacttaa aagggtaaac 9540
tatcctaaaa tattagtggt gagattataa atgattattt gtattttttc aacttatcta 9600
tgttttccat gattgtttta agaagtgtga atttctttga taatcagaaa aacattaagg 9660
agaaaggggg ttaagtaggg aggtagagaa agaggcatgg ggtggggaga gaggattgta 9720
gaaaagaaaa atatgttgga agatgaatga acaattttaa aactttatgt ttcacagact 9780
gctagcttgt gcatattttt ctttattatt gaatatatat gtttatcacc ctcagaagat 9840
ctggaagtac caattggcat gaaactgaat tgcaaatact gagctaagta tcacacctcc 9900
aagaccattg ccttggccag tgccattctg tgtgtgacat gtggcttcca gtgatgctca 9960
aagtattttc cgccaaaggc taatagagaa cacttcaaac ctgggcagca gcatctctcc 10020
cacagggttt aatatttata cttgtagcca cgtggctggc tttgtgcttc tcatctctga 10080
agtatggaac aggagccaac aaaggctgtc aatagttgga gtagtgggat tttccaagac 10140
aaaagcgtga gttattctcg tccacgtgtt tgctggctgc tcactggctc aggcagcccc 10200
ttggcaagct ctgtggctga ggctttaaat aaatagatgt agtttttgtt tcacaaccac 10260
tgaccttttc tggaggcact gttgattctg ggctttaatt ggcttctgtt gagtgacaca 10320
aggtgaaccc tctcttcaag agcagaagct cctatctgct gttaaccacc agcatcaatt 10380
caaagcaaat gccagaggac cacatacctc actgaactct ggggactggg gttacttgta 10440
gttatgtctc aataaatact ttttatattt taacttttgc atttttaagt tgtaaaagct 10500
atacacactc atggtaacaa gtctagtaag acagcagtat ataaagaaaa tatggccagg 10560
cgcagtggct caccccatag ttccaatact ttgggaggcc gagatgggtg gatcacttga 10620
ggtcaggagt tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatta 10680
ggctgggtgc ggtggctcac tcctgtaatc ccatcacttt gggaggctga ggcgggtgga 10740
tcacaaggtc aggagttcaa gaccagcctg gccaagatgg tgaaaccctg cctctactaa 10800
aaatacaaaa attagctgag cgcagtggca ggcacctgta atcccagcta cttgggaggc 10860
tgaggccgga gaatcacttg aacccggggg gcagaggttc cagtgagccg agatcctgcc 10920
actgcactcc agcctgggcg acagcatgag actccgtctc aaaaaaaaaa aaaaaaaaaa 10980
attggccagg taaggtggct catgcctgta atcctggcac tttgggaggc cgaggtgggt 11040
ggatcacctg aggtcaggag ttcgagacca gcctgaccaa caaggtgaaa tcccatctct 11100
accaaaaata caaaaattag ctggacgtgg tggcaggcgc ctgtagtccc agctactcgg 11160
gaggctgaga caggagaatt gcttgaacca gggaggcaga ggttgcagtg agccgagatc 11220
gcaccactgc actacaacct gagcgatgga gcgagactct gtctcaaaaa aaaaaattag 11280
tcaagtgtgg tggcgtgtgc ctgtaatccc agttacttga gagggtgagg cgggagaata 11340
gctcgaaata gcttgaaccc aggaggcaga ggttgcagtg agccaagatt gtgccactgc 11400
actccagctt gggctaccga gggagactcc atctcaaaga aaaaaaaaaa gaaagaaaat 11460
ataagtaatc tccaccttct ctcactccca tctttctgac aaaaccacta tttaaagcgc 11520
ccaggctggg cgtgcgggct gacatctgta atctgagcac tttaggaggc agaggcagga 11580
ggatagcttg ggtccaggag ttcaaaacag cctggacaac atagtgaaac tccgtctcta 11640
tgaaaaaaaa aaaaaaatag ccaagtgggt ggtatgtcat cctagctact tgagaggatg 11700
aagtgggagg atcgcttgaa cccaggaggt tgaggctgca gtgagctgtg atcatgacat 11760
tgcactccag cttgagtaac agagtgagac cctgtctcaa aaaaaaagtt tcatgtgtat 11820
tcacatgtca cgatcacagc tcactgcagc ctcaacatct ccagctcaag ggatccttcc 11880
acctcagcct gccaaataac tgggaccaca ggcacatgcc accacacccg tctaattttt 11940
aaacattttt gtagaaacga ggtctcactg tgttgcccag gctgatcttg aattcctcgg 12000
ctcaagtgat cctcccacct cagcctccca aagtgctggg attataggca tgagccactg 12060
cactcagccc cttcactcct tttctatgtt caaacaaaca tatgagtgtg tagacttatt 12120
ttctattgta tgtgaaaatg gaatcatata tgttattatt tctttcattt tatttagtac 12180
atattatgta cattattcta gattaacaca tataattgat ccaatttatt atttttaata 12240
gctacctaat attccattat aggaggttcc ataatttctt cccattcatt acttccccat 12300
tgatagatat tcatgttttt cttccaactt tttttgcaca acaacttatg ctacaataaa 12360
cattctacat ttattcctat actttgggtt ttatttccat aggagagatt cccaaaattg 12420
tcatttttgg gtcaaaggga atacacaatt ttaattctca ctgtaggtct cctttacagc 12480
agttgtttct ctcctccttt tgtctttctc tcccctctcc caccacattt tgccagcagg 12540
gcctgtgtgt ttaagaagga aagcctgcag tgagaactcc tctgtgccaa gtgtggatta 12600
tatcagctta gtggggaact ggagtctgca gtgtctcagt tacattgtgt ctctcttgct 12660
tttggttggc cagactgttc acaattcccc ttgctgattt attccatgct gtggaattat 12720
acatggtctt catccgtggc aggatcatct gaggggtggc tttttgggaa gggtgtcttt 12780
tcagaaagaa taggctcagt tactgtactt tctcacaaag ctatatctgt tatgtttttt 12840
tgttatgccc tttctttaat agttggattg aaaaaggttc ttcaattccc atcccggtct 12900
tctgtcttca ttttgaggac ttgggattta gggagtttta tgagtatata atcaatcaac 12960
tgtaactgat tatttgacat gaggataatt agttaagaag gtaggggtct tggagcttaa 13020
ggatcagtgc caagcaacag acgtgaacat ttttaaacaa atggttttaa caaacccggt 13080
attaggagca agcttcccag gagtactaag ctttcatttt ttaattttgc ccttgctggg 13140
atgtaaaact tcagtctagt ctaccagaat agagaggagc tggattctcc accacaccag 13200
ggctggagag gagaaaatgt cagagaagcg ttaagggaag ctggtaagta caaataagtg 13260
aaataaatat aaacagtgaa ctgacaaaat ggcaaaaagt gaatgaaatt tgaaaatcct 13320
cagctgaaga ttattgtgta accagtggtc ctgtgagcta gtggacactt tataaaaatc 13380
tgtgatctct aaaacatatt agatacccca gtgtgaatct gtgttcagaa tacaaccatt 13440
agctaagcaa gacagagaaa tgataagtcc tgttggcaga tattttgcta ttgacttcta 13500
taacatatgc tgcaattttt actcagcagc tttggaatgg atttctatgt cctaggttga 13560
aaactaaact aaaagaaaaa cagaatagaa gttactgcac ttaatttcta aggagaaaat 13620
tttaacttta gtttgtgcat gtatatgcct gcaaaataag cattaccctt tatgttaata 13680
caaacttcac atgaatgttt aattttcaaa tatgcactga ccagtaataa tgatggcaaa 13740
attagactct atagtaggtt tatgttttat aacttaggga ttctataatg tatcttagtt 13800
gatgtcgtag ttaatagtaa ggatagtaat atcttataca gtttgcactg tcgtctgagt 13860
aaagattatc tttaaacatt tgttcctgtc agaaaaattt taaggctaaa cctattataa 13920
gatattaagc atctgatttt ggctataatg gactatctgt gagtagattt ttactcctat 13980
acaggacatc tagaaaagct gagttttaaa aatctatttg aaggcataga agacctaata 14040
aggcagctag gacttgagag ctaagacctc agaaagaaga gaaactcatt gagtgttcca 14100
aattctaggc tactttttcc ctgtagacac ttaccatttt taagtagcac atgaggagaa 14160
cccaaacaat aagcagctgc taaaatcaga gaagccaggc agattattcc acagtctgat 14220
agggctgggg aggaaaaaaa aaaattgaat tcaaggaaac caaatgattc aggacatgag 14280
aaaccatgat catggacaga aaagaggccc agaaaaatca actcaatagt ctaagcaatt 14340
ttccttccaa gtcattcact gatttataag tagcgcagac caagaggttg caaaaatcca 14400
aacacaaaga aggtgctaaa aagctgagaa gctaatcaga gctacttgca atcttattac 14460
actaggaaga taaaaattat tatagaatgt aaagcccacc aatgtggtat ggcctgaaaa 14520
acaccctaag ctttcagttg ggactgctga cggattatgc ctgaccagtt aaaggaaacc 14580
agaaatagac ccggtcaaat aaaatattga agtccatttc ccgatcaact tagtcactga 14640
ttagattaaa gtaatctgtt cttattttaa caccctagca taagtcttct ccatattctt 14700
tggagaagaa aaaatgatcc agaacctgtg tatttttcat atgtggtttc tggtattcag 14760
caaagcaaaa caaaacaaaa acaggcatac caagatatag tttccagaat atggtacaga 14820
gagaacccag acttcctgag ttgagaagac agagctcccc atgtctgggg agaccagggc 14880
aactagagtt tgtaggacag agtattggag aggagagagc tgcagagaga accccagagt 14940
tcctcacagg gtacacctca agtataaagc tgagtactga gcagcacatg catgtaagga 15000
aactacctgg gataaagaaa gaactaccca aaaggattag aagaaatagt gctcattgtt 15060
cacacagggc tgggaattgt gcctattccc accagctaga cttgaaaagc tcataattca 15120
tggagggttg ggtagtatac tttgaaagac catgccttag tagtgggaag tagccctaga 15180
ttgagcactg cactgatcct gtctaacaaa tcttttaaaa agacccaaaa ggaacaaatt 15240
gttccagtta atttgactgc atcccagaac aaagctcaaa actatttaga ggtatttgga 15300
atagcagtat tagtaatatt gcagagggaa gaatattgcc agggataaag aaaatcattt 15360
cataatgata aaggagttga ttcatcagaa agacataaca gtactaaaca tttatgcatc 15420
taataacaga acttcaaaat acataaatga gaaattgata gtgttccaag gaggaataga 15480
caaatccata actgtagtcc aaagtttcat taaccttctc tcagtaattg atgaaataac 15540
agaaaataat taggtatata aaagaagata aaaatacaat caactagctt gacctcattg 15600
atctttataa gatactctac ccagctacag caaatacata ttcctctcaa gtgtacatgg 15660
aacatttatc cagttagacc atattctgaa ccataaaaca agtctcaata aatttaaaag 15720
gattttagtt atataaggtg tgttcttgat cacaatggaa ttaattaaga aatcagtaac 15780
aaaattctca aatatttggt aactaaataa catccttcag aataactcat tagtcaaagg 15840
agaaatcaaa aggaaaatta gggccgagtg gagtgactca catttgtatt cctaacactt 15900
tgggaagttg aggcaggagg attgcttgag gccaggagtt gaagatcagc ctgggcaaca 15960
gagtgagagc ctgtctttaa aaaaaataga aaaaaaaaat tagctgggca tggtggtgtg 16020
cactcataat cccagctact tagctggagg attgctttag cctaagagtt tgaggttgca 16080
gtgagctatg atcatgccac tgcattccag cctgggcagc agagtgagac cctgtctcta 16140
aaaaaattat ttttaataaa aaataaaggg aaatgagaaa atatttgggg ctgaaagtaa 16200
aagctcatat atcaaaagca gtacttaggt ggaattttat agtattataa gcttataagg 16260
tggggcacag tggctcacgc tggtaatgcc aacactgtag gaagtcgaga caggcggatt 16320
gcttgaaatc aggagttcgg gaccagcttt gacaacatgg caaaaccctg tttctataaa 16380
aaatacagaa aattagctgg gtatggtggc acgtgcctgt agtcccagct acttgatggg 16440
ggctgaagca ggaggatcac ttgagcccag gatttcgagg ctgcagtgag ccgagatcac 16500
accactgcac tccactccag cctgggtaac aaagtgagac cctgtccccc cacacccccg 16560
caaaaaaaag cttataagaa gaaaggtctc agattagtgt cctcagcttt catcttaaga 16620
aaccaaaaca gaaaaagagc aaatgaaatt caaaataagc agaagaaaga aaataagaaa 16680
tatcaaagca gaaatcaata aactagattt tgaaaagtag agaaaatcaa tgaaagcaaa 16740
tgctgtttca ttgagaatat taataaaatt gattaacctc ttgacagaaa acaggaggag 16800
gaaaaagaga ggagttacaa tttaccaata tcggaatgag agaggtgaca tcactacaaa 16860
ttctacagat actaatggat aataaggaaa cattatagct tttctccaat aattccatca 16920
acttattaat agatgaaatg aacaaattcc ttgaaagaca caagctacca aagttcactg 16980
aagaggtagt agagaatgta aaagcccaga tctattatag acagtctcga aagttagaaa 17040
tagaagagaa cttccctagc ctgataaagg gaatctatgc aaaacgtgca cctaacatca 17100
tatttagtgg taaagcaaat agtaatataa tcgatttttt ttcttttttg agacagagtc 17160
ttgctctttc acccaggctg gagtgcaggg gcgcgatctt ggcccactgc aacctccacc 17220
tcccgggtcc aggcgatctt cctgcctcag cctcctcagt agctgggatt acaggcacat 17280
gccaccacac cctgctaatt tttgtatttt tagtagagac agggtttcac catgttggtc 17340
aggctggtct tgaactcctg acctcgtgat ccacccacct tggcctccca aagtgctggg 17400
attacaggcg taagccactg cgcccagctt tttttttttt tttttttttt tttgagatgg 17460
agtcttgctc tgtcgcccaa gctagagtgc tgtggcgtga tcttggctca ctgcaacctc 17520
caactcctgg ttcaagtaat tctcctgcct cagcctcctg agtagctggg attacaggtg 17580
cccaccacca tgcccagcta atttttttat ttttagtaga gaatgggttt caccatgttg 17640
gaccaggctg gtctcgaact cctggcctca ggtgatccgc ccaccttggg atcaccaagt 17700
gttgggatta caggcgtgag ccactgtgcc tggcctgcct agacttttaa cttatttgtg 17760
taattacttc aagtatagat tactccaatt taaacacaaa gattgtgaaa ctagatgaag 17820
aataaacata ttcaaaatga ttattaaatg ttttaattgg tgacagagtt tttcatagcc 17880
ttttatcatc tcagtgcatc atgttttatt tgtaggtagc cacagagaaa cagctacatt 17940
tataagaaca ccatgaagaa taattaaaat gttctttttt tttttttgag acagagtctt 18000
gctttgtcac ccaggctaga gtgcagtggc aagatcttgg ctcactgcaa cctctacctc 18060
ctgggttcaa gtgattctcc tgcctcagcc tccctagtag ctgagattgc aggtgtggac 18120
cactacacct ggctaatttt ttgtattttt agtagagatg gggtttcacc atgttggcca 18180
ggcttgtctt gaactcctga cctcaggtcg atccacctgc cttggcctcc caaagtgttg 18240
ggattacagg tgtgagtgac cacacctggc ctaaaacatt cttttatccc tgacttcagc 18300
tgagtttagt ttgaaatgag gctctttatt tggggtgatt gggctttgca ggagggttgg 18360
tgggtggcct ataattcccc ccaatattgt atgtaagata ttacatgttt gtatacagtt 18420
tttcaggaga gagtccgtag ctttcatcag tctctcatga ccaaaaacta tttaagaatc 18480
atggcttgaa gaatgaaaga atcgagtgcc atgttaagtg tctaatttct caataatact 18540
tccctgaaac taatttctag agaataattc aaatgacttg atctaaatat gtgtgcatga 18600
gtcatcaaag cagcctggag taacatatta aaagttatcc caagggtctg tctggttcaa 18660
actctgatga aagccctata tttcttatcc tggactgggt ttctcatagt atgattccca 18720
gatcagcagc agcatcagca tcacctagga acttgttaga aatacaaatt ctcaggccgg 18780
ccccaggcca tacctactga gttacaaatt ggagatggga ccaggaatcg gtgttttcta 18840
aggagctttc caggtgattc tggtgtgcac taaagtttga taaccactgg gttaggctat 18900
aattagaaaa tcctgttctc cgccccgctc ccaagccagg tttagaacag tttgttaagc 18960
aagtatctgc agaaagacca gtctaatgtt gacagcttct attttccatc tttatggaaa 19020
aatcgtaaag cctcaaaagc ccaaatcacc ctcacacaag tgtcttgggt tgcacagcaa 19080
caccaaacaa cagtttagag taatccaatg tccagctgaa attggaatta tagagacaca 19140
gcatgtgagt tcactcacaa aaatttttac caggaggctt tttagggatg agccccgtaa 19200
ttccaagggc cttggctctc agcctccttt gaggcatata acacagtctc ttgaacagac 19260
tgaccctcag taatgaggtt tcattaccct cttccagaca tgtggcaccc tcacaaacat 19320
cctttaacag agtgctcagt atcaccatgc ttcgtttgca aagtaactta atgaattcgc 19380
tcagcctata ttcttagtac ccagtggtag ggatctcagc tgtagcagca taaaacttga 19440
actgtccaaa accagtctct gaaaccttca agtgtttatt ctgtctactc ctgctgttgc 19500
ttgaagcttg atttgttgtt acaccttact gttttgctga tgagaaatag cacagggtac 19560
ttctcagtgg ttctcattaa aggagggcag ccaagtggaa ttcattcttg gctcttaata 19620
gttttcaaat gagaatttta ttgcatacta atgagcacta attgacattt gtgactgttt 19680
tttatggaaa taatgcatgt acaatttgca taatagtacc taagtgcttt taggtaacag 19740
tacaactctg ggaagttggt gaaggttttt gtatgatgct ttttaaaaaa gttcccaaac 19800
cccagcccct agaatagtat agaatattaa caggtctctg ggatccaaat ataaggcagt 19860
agtagtgact cagttcctgt agttgtacca gcttgtacct gagagtcaga aaatgcatca 19920
gggcaggtct ctaaaagcag gaagcgctcc cacagtagcc agggaggatg ttccagccct 19980
ctctaccttc atgtgtcaac cctcctgctt ctcctaagtc atgagtatct agacagtgct 20040
gaggattgtt ccaaggactc ctacactgta aaatgttttc taaacatcac ttggttgata 20100
tcaacaaaca tggattgatc acctactatg tgccaggcac tgtgctagat gccagagtaa 20160
gcccatgttg gcttgctgcc tgctgcatcc ctatctctta gcacaatgag gcaacagtta 20220
tccatcaatg tttattgaat taatgaacat gctgtctgcc ctcagggatc tgaggattca 20280
ttattcttac aaaatctgac gttgaataca gtataaaatt tgttgctctt catgttagaa 20340
atattaatta ttcagaactt ggaattctgt taggaaattt agagaaacaa gataatcttg 20400
gttttatgtg ccccaagttt tctgtatatc aaatgaccct tttaaatttt gtgaaaatga 20460
aagaagccaa tgtttactga agatctagta cgtatcagtt acttttgcac acatcctata 20520
catcctatga tttaagcatc aacaaaacct atgaggtgta gatagtatta tctgtgttta 20580
attgagcaag cagctaagaa ctggagaagt gactaaccta aggcatcaca gatagaaaat 20640
tgtggaactg ggacttaaat tcagcctagg ctgtgtctgt tgcactgccg cttattacat 20700
taaatgatcc taggatatgt taagcaaagc caaactctga agtattgtac tagtgatacg 20760
gctccgatga ctggaggaac actggggttc ttggtctcat gccggtttgg ataaaatgac 20820
atggacacac gtggagtggt tttagggagg gaaaagttta ataggcagga aagcaggaag 20880
gaagaagaaa acagctcccc ggtacgggga gagaagtagg gggattcaaa caaagagaaa 20940
acctcatgtg cggcagaaaa gtggctgctt atatgaggat gcaggaggag gtggtgtctg 21000
atttgcatag ggctcagggg attggtttga ccagtcatgt cattcctgca gcctgtgaaa 21060
aaactgaccc tcccacccta gctttttaat atgcaaatgc agggcgccat tatgttttac 21120
acacatgggg acatgtgggg gtggccatgt tgccaggcac atgtaggggc aagggcaaga 21180
agatggcagg aatcaccatg tttggatgga cccagtttct aatggctggc atttgcatat 21240
caaagcttgc tggcccagct cagagccggg gctttcctgc tagacaagaa acgtttctgg 21300
agctgcttta aaagaaataa aaactcccca aggacccctt ttcctctcta tctgcctaaa 21360
ataatttatt aataactcct gtaacactag gatggaggga tgaattggtc caggggtctt 21420
ggtgtgtgcc ctgcattcag ttgacctact gtttacaata cacctactgt ttacaacact 21480
attttctaga tcttgtgggg aacccaaacc aagggccagt ctggctcacc tataattcca 21540
ccaagcagcc agaaaagtat aaacgctcta cagcaaaggg ataaatcaag gtttagtaga 21600
agaaaagctt tataagtaat gtggaactaa aaggttgaat atagttttca ataatgttga 21660
gcataaatgt tctccagatt gtggaaagat cactaactgt tggctgggaa gggtaggaga 21720
ggagagagtt tgaaacacag agaataggaa ggagtggtga tgtagtccaa taactcaccc 21780
agaacccatg gacgtgaaag ctttgtttgc tctcagatcc ataactagac taaaggagtg 21840
aatcagatct gctcccctgc accccaccct gctcaccttc cacacctgcc aagggccacc 21900
cagcaattcc attctgcttg tcaaatcccc taaggaggat atgtctggaa cagccaccac 21960
tcctccccct gctcttccct ctggtatgtc aggattccct gcacaaccgt gctccagggt 22020
ccttgggatg attattcaga aaccagagaa gtatgtagaa aacttaatcg gaggcactta 22080
aaggctttaa aagggaattt taaaaaccat ctttccctct tttataaggc agtctgagta 22140
tttaagaagc aaattaattg agtccacttt acagtgttgg ggcaaaagca tgcaagttcc 22200
aacatttaca cactaacaga aaattctttt cccttccact gtgctccttt tctttcttgg 22260
gcctgctcca caaacttcta accacagtcc taaattggta ccccatgacc ctgtgtgctt 22320
cgattgccta cactggtttc agacccacgc tgtggattca aatcaaacct gcctttctcc 22380
ctgttactat gtccacccag caccctcctt gcacacacag tctttctctt ctttcctcca 22440
tgtgcagacc tttaccacag ctgtcccaaa tgtgtgaaag gccaaccata actcttcctt 22500
taaaggtcct ttagagcagt atggaaagag tgctgaactt ggaagaccta gattctcttt 22560
ctatactcat tatgtgatcc tgagcccctc acttaacctt gcagggcact tacaaaataa 22620
agagatggag ttcatgatat cttaaggtca ttttccatgt ccaacattct ctgactcttc 22680
atctttccct gactcaacat tctgttccta tatagtcaac accttcccac cttaatctca 22740
tgctcatgcc ctcttagaaa gtctttacaa ctgttgaggg tgcagtggct catgcctgta 22800
atcccagtac tttgggaggc cagagtgggc agattgcttg agctcaggag tttgggacca 22860
gcctgcataa catggtgaaa ccccgtcttt attaaaaata caaaaaaaaa aaaaaaaaag 22920
ccagatgtgg tggtgcttgc ctgtggtccc agctactcag gaggctgaaa tgggaggatc 22980
acttgaaccc aggaggcaga ggttgcagtg agctgagatc atgtcattgc attccagcct 23040
gggtgacaga gagacaccct gtctcaattt aaaaagaaaa aaaagaaaga aagcggcggg 23100
ccgcggtggc ttacacctgc aatcccagca ctttgggagg ccgaggcagg tggatcatct 23160
gaggtcaggg gttcgagacc agcctggcca gcattaagaa actctgtctc tattaaaaat 23220
acaaaaatta gctgggcatg gtggtgggca cctataattc cagctactca ggaggctgag 23280
gaaggagaat cgcttgaacc cgggaggtgg aggttgcagt gagttgagat cgtactattg 23340
cactccagcc tgggcaagaa gagtgaaact ccatctcaaa aaaaaaaaaa aaaaagaaaa 23400
tatttgcatc tgtgaactgt cttctgtgtt gaggatgttt gtggcagaag gagatagacg 23460
taggctctgt ctacgtctgc ctggtgcctc cacaaggagc agtgtatgct cagagaatag 23520
aagtgaattt tactattagt ataggtgacc catattgaaa atgtttgtaa atctgctacc 23580
agaacaacac agtcattcaa agacaattaa aaatgcattt tatacttcct gctatttata 23640
attattcatg gatctgctgc ctacagtcag gtagtaaaag gagagccaga aggaatcata 23700
gtgaacatct catacaatgc tatctttgtt gttggtttga acataagcat ttttgcgtga 23760
atttgcgtgt aggtctcttt tatttctctt attgcataac ctgaggctga aatacttcaa 23820
gtaatgtatc tatttgctca tattgggtag aaacatccct attattccaa ttttcccttc 23880
tcctgcttaa aacatatagt gaaatgaaag atgcagagat aaggaaatca gggaaaagaa 23940
aaatagtcat aggatactaa aatgagccac agatacctga aactgcatag ttgctataaa 24000
tgagccataa atttgattct gagctttcca gtggccccaa aaagataaac ataatagtat 24060
ttattccatg acataaaaat gtatttgtat ttctctgtgt tcaagaggaa gagaaatttg 24120
tactatgggt cctcatgaag gagccactaa gtcagtgttg tagaccacac attcaacgat 24180
atcgtattaa tacccatgat gatgaattca ttcattcaat aagcatttat tgagtactta 24240
ctttgtgctg tatatgtttc agtgtattgc agtaattatt ctttttgatg ctcaaattgt 24300
cctattgtgg gtcagtagga gcccgttgat tcatgtcctt ttgacattat tctgtagttt 24360
ttgatacttt ttttcctagc atgatgagat gttccaggct tatgtcgtat atttcttgtt 24420
ccgtaactca aattgaccat tttgttaatg aaacttgatt tttttcagtg aaaagtggtt 24480
ttatagaaca caatctgggc acttgaagtg tttattgtta ctgggttgtc attacttaca 24540
agactcagtt aacaaattag gaaaaagatt gatttagaaa gaaaataaat cctgagttca 24600
tattgttatt tccaatttaa agattaaagg gttttcgtat aacttatttt atatgtgtat 24660
gtcttttctc ttactttgaa atcttggttt ccaataacat gaacataatt acttccttta 24720
tcctaatagg tacgtatatg tgtatatgtc tatgtatgta tgtatgtagg tatgtatgtg 24780
tgtatgtttc tatctgtaaa acaggaaaaa tacccaccta atggagctta agatttcttt 24840
atgagtattt tttgtcctta gggtatttaa tcaaattact gttacttaaa ataatgtttc 24900
tctatgtggt tatgccatca acttcatata caattatttt atttcaattt gtcttcgatt 24960
tttaaggatg gttttcttct tctgatttaa ttttgttttt aaattatgta aaatattttc 25020
ttggtttcag agtcaaatct atgaacattg agaggtctat tttgcctctc tgtcccctcc 25080
cccttattat tttactcccc ttatagataa tgcttttatt tttccattac tttttttttt 25140
tttttttgga gacaggagtc tcgttctgtc acccaggcag gagtacggta gtgtgatctc 25200
ggctcactgt aacctccacc tcccaggttc aagcaattat cctgcctcag cctcctaagt 25260
agctgggact acagacactg accaccatgc ctggctaatt tttgtatttt tagtagagac 25320
agggtttcac tgtgttgatc aggctggtct caaactcctg acctcaagtg atccgcctgc 25380
cttggcctcc caaagtgccg ggattacagg tgtgagccac cgtgcccagc ctctattact 25440
ttttgaaaat aagccaatga cctatatgta tcctatctcc tttcttacac aaaaggtagc 25500
aggccagagt tcaagattac agtgagctgt catcatgcca ctgcacttta gcctgggcaa 25560
cagagtgaga ccttatctct aaagaaaaac aaacaataaa aaattttaaa aataatttct 25620
atgaattaaa aataatttta aacacaactg catatgaaga caacaaagga aaactctcag 25680
gaaacactga aatatgaaaa tcaagtgaga ttagagcaaa taaggatgtg tatgggaagg 25740
ttctgtagaa gacagattga ggcccaaaca gagagagctc taaatacatc atgaaggtta 25800
ccagaaatgt gagaaattcc tgaagaagag ggaagaagca aatcctctcc aaatttagtt 25860
cacttagttg ataatcatta gttgattccc agtagagtca gtcttttatc atcagtgcca 25920
ccactgttgt tctctgcatt aacaaaggag atattaatct ggaaagctgc aatcattttc 25980
actgtagaat cagcctttta ttttttaggg ttttttaatt tttttttttt aggacacctt 26040
catttaagat cacttcatat ctcctctggc ttttgcaaat gctctttggc tgatctactg 26100
tttccaccac tgtcctcaac attttttagt atattattta atttatgtat gtattggtgt 26160
ccactgatta ttgtttgcct tcccccattg gaacacagat tctataaaag tagggatctt 26220
tattttgttt accactgtat tccaggtgcc tagaacagtt cctttcacat tgttggtgct 26280
caaaaagaaa aaagttaaat gaatgaatat cagcagcaag agcattttga ggagaaagca 26340
aaggtgtaac tgtgggggtc tccattaatg tatgtatatc atcctcttat acatttgtcc 26400
catcacccgc tagccctgga actctcatta tttttttttc tggtaatgca ggctccaact 26460
caactggcaa tgagaatatg aactgaggca actgtatttg aaaaatgaaa gaatataggt 26520
gatatgggtt taaagaattc agtatttgtg tatttttcca ataagtacat gcttatgagc 26580
atagccttac aaaataacaa aaataatttt ttacatttac tcacacactt accatttcca 26640
gcactcttca ttcctttgta tagatccaaa tttgtatctg gcatcatttt acttctgcct 26700
aaagaactaa ctctaacatt tttttatagt gcatgtctct cagattttct ttgtctgaaa 26760
attactttat tttaactcca tttctgaaat acattttcag tgggtattgt attctgggct 26820
gacttttttt ttttttccca gtgcttgaga gatgccattc cattctcttg tggctttcat 26880
tatttttgat gaaaaatcag ttgtaagtct tactcttgtt cctctgtaca taatctgact 26940
gctgcttcta aaattttatc tttattgctg gtttttagca atttctgtgc cttgttttgt 27000
ttttgttatt tagtgtttgt tctgcttggg attggttgag cttggatctg taggtttata 27060
cttttcatca aatacgaaaa attttggtca ttatttttca aatatttttt ctactcctcc 27120
ctcctcactt tttccccctc aaacagcagt tacatgtatg tcagacaact tgctattatt 27180
ctataagtca ttgagacaat gttcattctt ttttattttt aatttttgtg ggtaaatagg 27240
tgaatatatt taggggttca tgagatgttt tgatataggc atgcaatgta aaataagcac 27300
atcatggaga atggggtatc tattccctta agcatttatt ctttgaatta aaaacaatcc 27360
acttacactc ttatcacttc tcagcctttt gggataagat catgtgtaaa aacaatgtac 27420
ttacactttt cattttaaaa tgtacaatta agttattatt gactatagtc accctgttgt 27480
actatcaaat agtaagtctt actcattcta actaattttt tataaacttt aactataccc 27540
acttctcctc ccacctccca ctccctttcc aacctatggt aaccatcctt ctatactctg 27600
ttcatgagtt cacttgtttt gatttttaga tcccacaaat aaataagaag atgtgatgtt 27660
tgtctttctg tgcttggctt atttcactta acgtaatgat ctccagtgcc atccatgttg 27720
ttgctaatta ctggacctaa ttcttataca tggatgaata gtacatcatt gtgtagatgt 27780
accacatttt ctttattcat tcatctgttg atggagactt agattgcttc caaatcttag 27840
ctatagtaag caatgctgca acaaacagga gtgcagacat ctctttaata tactgctttt 27900
ctttcttttg ggtatatatc cagcgatggg attgccagat catacagtag ctcaattttt 27960
agttttttga ggaacctcca aactgttctc cataatggtt gcactaatgt acattcccac 28020
caacagtgta caagggtccc tttttctcca catcctcacc agcatttgtt attgcctgtc 28080
ttttggatat aagccatttt aactggggtg agaagatatt ttagttttca tctgcatttc 28140
tctgatgata aatgacattg agcatctttt catatacctg tttgccattt gtctgtcttt 28200
gttggaaaaa tttctgttag ctcttttgcc cattttttta atcggattat taaatttttt 28260
cctatagagt tgtttgagct ccttatatag tctggtgatt aatcctttgt cagatgggta 28320
gttggcaaat attttctgtc attctgtgag ttgtctcttg actttgttga ttgtatcctt 28380
tgatgtacag aggctttgta acttgatgtg atcctatttt tccatttttg ctttggtcgc 28440
ctgtgcttgt ggcatattgc tcaagaaatg tttgcccaga ccaatgtcta gagactttct 28500
gcaatgtttt cctgtagtat tttcatagtt tgaggtctta gatttaagtc tttaatccat 28560
tttcatttga tttttgtata tggtgagaga tgggtgtcca gtttcattct tatgcatgtg 28620
gatatccagt tttcccagta ccatttattg aagagaccct ctctttccca gtgtatgttc 28680
ttggcacctt tgccaaaaat gagttcactg tagtttctgg gttctctctt ctgttctatt 28740
ggtctgagtc tgtttttatg ccagtactat tctgttttag ttacaatcat tctgtagcat 28800
aatttgaagt caggtaatgt gattcctcca gttttgttct tttcactcag gataccttta 28860
actattctgg gtcttttgtg gttccacata aattttagga ttgtattttc tatttctgtg 28920
aagaatgtca ctggtatttt gatagggatt gcattgaatc tgtagattgc tttgggtagt 28980
atggacattt taacaacatt gattcttcta atccatgtat atgggatatt tttccatttt 29040
tggtgtcttc ttcaattttt ataatctgtg ttttatagtt ttcattatac agatctttca 29100
cttctttggt caggttaatt cctagatatt taattttatg tgtggctatt ataaatagga 29160
ttacattttt atttcttttt cacatagttc actgttggca tatagaaatg ctactgattt 29220
tttataaact tttatgttat gttcaggtgt ataggtacag gtttgttata taggtaaact 29280
catgtcatgg ggtttgtcgt acagattatt tcatcaccca ggtactaagc tagtacccat 29340
tagttatttt ttctgatcct ctccctcttc ccactcttca ccctcagtag gccccagtgt 29400
ctgttgttcc cctctgtgtg tccatgtgtt ctaatcattt agatcccact tgtaagtgag 29460
aacatgcagt atttggtttt ctgttcctgt gttacttttc taaggataat ggcctccatc 29520
tccatccatg ttcctgcaaa ggatataatc tcattctttt tatggctgca tagtattcca 29580
tgatgtatat gtaccacatt ttcttttttt ttcccttcaa cttttatttt aagttcaaga 29640
gtacatgtat gtacaagatg tgcaagtttg ttacataggt aaatgtgtgc catggtagtt 29700
tactgcacag atcatcacat cgcctaggta ttaaggccag catccattag ctattcttcc 29760
tgatgctctc cctccctcac cacaccccct ccgacaagcc ccagtgtatg ttgttgcccc 29820
ctcacatgtg tccatatgtt ctcatcattc agctcccact tataagtgag aacatgtagt 29880
gtttgggttt ctgttcctgc attagtttgc tgaggataat ggcttccagc tccattcatg 29940
tccctgcaag gaacatgatc tcattccttt ttatggctgc atagtattcc atggtgtata 30000
tgtaacacat tttctttatc tagtatatca ttgatgagca tttaggttga ttccatgtct 30060
ttgctattgt taatagtgct gcagtgaaca tatgtgtgca tgtatctttg taacagaatg 30120
atttatattc ctttggatat agacccagta atgggattgc tgggtcaaat ggtatttctg 30180
cttctaggtc tttgaggaat tgccacacta tcttccacaa tgattgaact aattcatact 30240
cacaccaata attccttttt ctccacaaca ttggcagctt ctgttgtttt ttttgacttt 30300
ttaataatag ccattctgac tggcatgaga tggtatctca ttgtggtttt gatttgcatt 30360
tctctaatga tcagtgatgt tgagcttttt ttttcatatg tttgttggcc agatgtatat 30420
cttcttttga gaagtgtctg ttcatgtcct ttgcccactt tttaatggtg ttgtttgttt 30480
ttcttgtaaa ttggcttaag ttccttgtag actctggtta ttaaaccttt gtcagataga 30540
tagattgcag aaatttttct cccattcttt aggttgtctg tttgctctaa taatagtttc 30600
ttttgctgtg cacaagctct taagtttaat tagattccat ttgtcatttt tgctttcatt 30660
gcaatcactt tcggcatttt tgtcatgaaa tcttttcctg tgcttatgtc ctgaatggtt 30720
ttgcctagac tttcttctag agtttttttt tatagttttg ggttttacat ttaagtcttt 30780
aatccatctc cagttaattt ttgtatgtgg tgtaaggaag gggtccagta ttaattttct 30840
gcatttggct agccagttcc cctagcgcca tttgttaaat agggaatcct ttccctattg 30900
cttgtttttg tcaagcttgt caacagtcag atggtggtag gtatgtggtc tgatttctga 30960
gctattttgt ttcattggtt tatgtgtctg cttctctaca actaccatgc tatttgggtt 31020
actgtagcct tgtactatag tttgaagttg ggtagtgtga tgcctcaagc tttgttcttt 31080
ttgcttaata ttgccttggc tattagggct cttttttggt tccatatgaa ttttaaaatg 31140
attttcttct aattctgtga agaatgtcaa tggtaattta atgggaatag cattgaatct 31200
ataaattact ttgggcaata tggccatttt catgatattg attcttccta tccatgagga 31260
tgaaatgttt ttccgtttgt ttgtgtcttc tctgatttct ttgagcagtg gtttgtagtt 31320
ctccttgaag aggtccttca cttcccttat tagctgtatt cctaggtatt ttattctttt 31380
tgtagcaatt acgaatggga gttcattcac aatttggctc tctgcttgcc tgttgttggt 31440
gtataggaat gctagcaatt tttgcacatt gatgtttata tccttagtct ttgctgaagt 31500
tgcttatcag cttaagaagc ttttgggctg agacaatggg gttttctaga tataggatcg 31560
tgtcatctgc aaacaaagat aatttgactt cttctcttcc tatttgaata ccatttattt 31620
ctttctcttg cctgattgcc ctggccagaa cttctaatac tatgttggat agaaatagtg 31680
agatagggca tccttgtctt gtgccagttt tcaagggaat gcttccaact tttgcccatt 31740
cagtatgata ctggctgtgg gactgtcata gatggctctt attattttga agtatgttcc 31800
ttcaatacct agtttattga gagcttttaa catgaaggga tgttgaattt tatcgaaggc 31860
cttttctggg cctattgaga taatcatgtg gtttttgtct tttattctgt ttatgtgatg 31920
aatcacattt attgatttgc atatgttgaa ccaaacttga atctcaggga tgaagccaac 31980
ttgatcgtag tggatacgct ttttgatgtg ctgctggatt tggtttgcca gtattttatt 32040
gaggattttt gcctcaatgt tcatcaagga tattggcctg aaattttctt tttttgttgt 32100
tgtatctctg ccaggtttgg tatgaggatg atactggcct caagaatgag ttagggagaa 32160
gtccttcctt ttcaattttt tggaaaagtt tcagtagaaa tggtaccagc ttttctttgt 32220
accgctggta gaattcagct gtgaatctgt ctgatcttgg gctttttttg gttgttaggc 32280
tatttgttac tgcctcaatt tcagaacgtg tcattggtgt attcagggat tcaatttctt 32340
tctgcttcag tcttgagaag gtgtatgtgt ccaggaattt atccatttct tctagattct 32400
ctagtttatg tgcatacagg tgtgtgtagt attctctgat ggttgtttgt atttctgtgg 32460
gatcagtgat gatatcccac ttaacatttc tgattgtgtc tgtttgattc ttctctcttt 32520
tgttctttat tagtctagtt agttgcctat ctttttatta attttaaata aaacagctcc 32580
tggattcatt gatttttttg aaaggttttt tgtgtctata ttttcatttc aactctgatc 32640
tgatcttggt tatgtcttgt cttcttctag ctttgaaatt tgtttgcttt tggttctgtc 32700
attcttttag ttgtgatatt aggttgttaa cttgagatct ttctagcttt ttgatgtggg 32760
catttagtgc tataaatttt cctcttaaca ctgcttcagc tgcaccccag agattctggt 32820
atgttgtctc tttgttctca ttagtttcaa ggaatttctt gatttctgcc ttaattttgt 32880
tatttaccca ggagtcattc aggagcaggt tgttcaattt ccatgtagtt gtgtggtttt 32940
gagtgaattt cttaatcttg agttctaatt tgattgtgct gtggtcagaa agactgttat 33000
gatttcaata cttttgcctt tgctgaaaaa gtgccatgtg gtgatgagaa gaatgtatat 33060
tctgttgttt ttgggtggag agttctgtag atatctatca ggtcctcttg atccagagct 33120
tagttcaggt cctgaatatc tttgttaatt ttctgtctca gtgatatgtc taatattttc 33180
agtggagtgt caaagtattt cactattatt gtgtgggagt ctaagtctct ttgtaggtct 33240
ctaagaactt gctttatgaa tctgggtgct cctgtattgg gtgcatatat atttaggata 33300
gttagctctg cttgttgaat tgaacgcttt accattatgg aatgcccttc tttgtctttt 33360
ttttatcttt gttggtgtaa agtgtgtttt gtcagaaact aggactgcaa cccttgcttt 33420
tttctgtttt ccatttgctt cataaatttt tctccattcc cttattttga gcctatgtgt 33480
gtctttgcac ttgaggtggg tgtcttgaag acagcatact gatggccctt ggctgtttat 33540
ccagcttgcc attctgtgac ttttaattgg gggcatttag cccatttata tttaaggtta 33600
gtattgttat gtatgaattt gatcctgtca tcatgatgct agctggttat tttgctgact 33660
tgtttttgtg gttgcttcat agtgtcactg gtctgtgtac tttagtatgt ttttgtagta 33720
gctggtaaca gtttttcctt tccatattta gtgcttcctt caggagtgct tgcagggcag 33780
cctggttgtg acaaattccc tcagcatttg cttgtctgaa aaggatctta tttctccttc 33840
acttatgaag cttagtttgg cccgatgtga aattctggat tggaaatatt tttctttaag 33900
aatgttgaat attggtttcc agtctcttct ggcttgtaga gtttctgctg aggagtccac 33960
tgttttctgt tgggcttccc tttgtaggtg acctggactt tctctctggc tacccttagc 34020
attttttttt tcattttcac cttggagaat ctgatgatta tgtatcttgg agttgatctt 34080
cttgtggagt atcttactgg ggttctcggc atttcctgaa tttgaacttt ggcccatctt 34140
gctagcttgg agaagttttc ctgtatgcta tcctgatgca tgttttccaa ctcagttcca 34200
ttctgcccct ctctttcagg taccccagtc aagtcatagg tttggtctct ttacataatc 34260
tcatatttct ctgaggtttt gttcattcct tctcttttta tttgtttctg tattcttgtc 34320
tgcctgtcta tatgcagaaa gatagtgttc aagctctgaa attctttcca ctgcttggtc 34380
catcctatgg atacttgtga ttgcattgtg aagttcttgt gtattacaag aactttattt 34440
ttttatcttt atccagtcta ccattgatgg gcatttaggt tgattctatg tctttgttat 34500
tgtgaataat gctgtaatga acatactaga atgattcatg tttatttggg taaatgtgtg 34560
ttgatttcgt atcctgcagt tttattgaat ttatcagttc taatcatttt tcttgtggag 34620
tctttaggtt tttccaaata taagatcata ttgtctgcaa acaatgatca tttgagttat 34680
tccttttcaa tttggatgct ttttatatct ttctcttatc taattgctct agctaggact 34740
tccagtagta tgttgaataa cagtgatggc agtgggcatc cttgttgtgt tccagatttt 34800
agaggaaagg ctttgtcctt cccctatgcc ccaggtaggt ccaggagtca aggactagag 34860
tccaaaacct tagaagtcta cctggtattc tattatactg tggctgagct ggccctcaga 34920
ccacaagaca cagtccttcc cactcttctc tcccctttcc aaaggcagag gaactgcctt 34980
tagtagagac agggtttcgc catgttggcc actgccaacc cagcccatga ggaggactgc 35040
cagactactg ctgatgttcc cttaaggccc aagttctctt aaatcagctt gtcctgaatg 35100
ttacctagcc tgagactcac ccttcaggac agtgggctcc cctctggccc agggaaggtc 35160
cagaaatgct gcccaagggt caagtcctgt aatcagggac tccaagagcc ctcttggtat 35220
tctaaccccc tgtatctgtg gtggtaccta aggtgcaaga caaagtccct tttacatttc 35280
cttctgcttt tatcaagcag aagttttgtc ctgcagccac cacagctggt aatgtactga 35340
gttctacctg aagccaggaa gtctcagagg ctcacccaag gccctcaaca tagtccctgg 35400
ttattgctgc tggttattca gaaccaaggg ctcttcactt agcaggtgat aaatgccggc 35460
agggctgggt cctttccttc aatgcagtgg gttccctctg gcccagggtg tgtctagtaa 35520
tgtcacctgg tttctagggc ctagaatgga ggcctcatga ctctgaccag tgccctatcc 35580
tgctgtggct gcgctggtat cctagacgca agacaatggt ctccccactt ctccctctcc 35640
tattctcaag tggaaggaag gggtctcttt tggagctgta agctgtgtag cctggggtaa 35700
ggggaggggt gatgccaata ctctcttggc tgccccagct ggtgtctcag taggttgcat 35760
gcactcccag tctgctgtct ctgggcctag ttcagcacca ggactcacct aagagttgca 35820
gtccttatgg cctagactgc ttttgaagtt tacttggaga caaagagcac tgtggccttc 35880
actggtgagg tttacaggca ctcaagttta gaccactggg attggtgatt cttctctggc 35940
tagggctgtt ttaaatcctc cctccgtttg cacatttcag ctgagtttga tctagtttgc 36000
ctttctgctc tgatttctgg ttcttatgaa ggtgtttttt tctgtgtaga cagctgttaa 36060
cttggtgtcc ttgcagaggg aatgatcagt ggagccttct atttcgccat cttgatccgc 36120
cgccatatat cattcttatc aatcattttc tgtttatgca cctgaaaata cactggtata 36180
caaaattaag atccttactt tcacagaatt tgtgttctaa tgggggaagt caataatcgg 36240
tggacaccaa tacatatata aattaaataa cacattaaaa ggtgttgagg acatgctggg 36300
catggtggct catacttgta atcccagcac tttggggggc cgaggcgggt gcatcacttg 36360
agatcaggag tttgagacaa gcctggccaa catggtgaaa ccctgtctct actaaaaata 36420
caaaaattag ctgggtatgg tggcaggtgc ctgtaattcc agctactagg gaggctgagg 36480
caggggaatc gcttgaagct gggaggcaga ggttgcagtg agctgagatc ctgccactac 36540
actccagcct ggacaacaga gtgagactct gtctcaaaaa aaaaaaataa ataaaaataa 36600
aagctgttga ggacaatgga ggaaaaggca gatcagagaa agaacattta caaaagccag 36660
agggagtgtg aagcaatttt aaatgaggtc agatttttgg ataatttcta ttgctatgtt 36720
tttaagttaa ccaatgtttc tttttgcaat gtctgatctg ttacattttt atttcagata 36780
ttatattgtt atctctagaa gttctattta gatctccttt ttatctttca attctctcct 36840
cattttgttc atattttgct ttatatccta gagcatattt ataatagttg ttttaaggtt 36900
cttgtgtgat agttatatca tttctgttat ttctgtgtct gatattattt atctattttt 36960
taaaacttta tgggtatagg tcatattttt tcatttcttt gaatgcctgg tgattatttt 37020
gaattttaca ttgttgagca ctggatgttg ttatattcct tttaagagca ttgagttgtg 37080
ttctggaatg cagttgagtt tttacagatc actttgatcc atttgagact ttcctttagg 37140
gtatatccag agtaacatct agtttagagt taatttgttt ttactactaa gatgtggctt 37200
ttctgaggat tttatccaat gtcctgtgta ttttggggtc tctccacact ggctgatgga 37260
aacacagggt agtctcagcc ctgtgtgagc tccaggaatt actcagctat tgcctatcag 37320
tgtttttttc ttcaactcca agtagtttct tccagctcat atccaaatca tacttaggag 37380
aagactgggg gggatcctct gcagatttcc aaagtgctct ccccactctc tgtatctccc 37440
tcttcttcat tactctgtcc cacaaattct aaccacctca acatccttaa attccaatcc 37500
attccccctt acctcaggta gaattctagg ttctgattgg ttttccctcc acgtgctgtg 37560
acctggaaat gacctccagg cagtatctct taggaagccc agttgtgtgg catctgttgt 37620
acaatgcctg aaaatgattc tttcatgtgt tttgtctggt tttcaacttg ttcacagaaa 37680
aaagcaattt gcacagcagt taattcttca cagacagaag cagaagttct accaactgca 37740
aaacaaccaa aacaacttgt taaaagacag tatttgtatg actggtcata aattacgtat 37800
agaagaatag agattttgtg agaaagatat gggcctgtac agaggggtga acttgcaaat 37860
gaccatcttg cttggggata gtgtctgttt tcctgatcct aatcactggg aaggattctg 37920
taatctctgt caaataaatt gcaaacacta ccacacatgg ccttgggtct actactgtct 37980
atgacataaa cagtttctcc ctagagactt agttgtgagg gtacaggggg aaggtagctt 38040
ttggaggggc ctggaagacc cttccctttg tgccttcgat tctgtatata tcttgtggtc 38100
agaagtctta ccattaccct ctctgataac tccccaccca ctttcccaat cactaaacac 38160
tttttgaaac cattcaactc tttcctttca atgattgagc ccttcattgt ttcatcagct 38220
cctcttgtgt gaatctctct gaatgtgtgc caagtttgca gtttaatgcc tgtcccatgt 38280
aggagcccaa tatcacggta tataaagttt ctacactgga tatccatgga ctgaagaggg 38340
gcctagcatt cagggttcca agccagtgag tttagcttat ccaagggtac ctctagaatg 38400
tgctcagaaa tttattccaa gtcagagttg catcccccag gactttaggc tcagatggac 38460
aaccccatca tatttacaga atccctcaaa gataatttaa gtttaagatt gtcagcccac 38520
ctggggtgca cagtgttgac cagggtttct taaccttagc actgttgaca tttggggcca 38580
gataattctt tgttgttcag accatcctgt gaattatagt atgtttagca gcatccttgg 38640
catctaccta ctagatgtga atagcatcct tctcttaatt ttgacaacca cagatgtctc 38700
cagaattgcc aaatgtcccc taaaggtgca aaattgcata gttgagaact actggtaaag 38760
aggcactatg gcatgccaag ctctagggag cccacagaag tgcacctctg ggaactaaag 38820
ctgaagaaac ccaagaggcc ccttggtatc ttcttggaag aagttagtcc agagtgtctg 38880
caccatgtgg agtgtatact gggatgacat tgaccttgga atgtaaactc ctgggattct 38940
tgcctctgca gatttggagc agggttttct tcttctctgc ttttcagttt acttatttga 39000
aaatgaggaa tggtgtttac atcacaaaac actgtagtga ggacaaaatg aggttttatg 39060
tatatataca cccatacata tacatataca cttcttccaa atgatataat aatatataaa 39120
cattgaatga ataatggttc aaatataagt gtacttattt gccactatga ttaaaagggc 39180
aatataggaa aaatacattt tcttctaatc catcatgttg taataatcct ccctgtggtt 39240
gcagtatggt tctgtgctag aaggcacaat aggaaatctc taactttaaa aaaaaagaaa 39300
agaaaaaata tctttctagc aattaaaatc tcaactaaat tagaatgcaa ataggttttt 39360
atatttgctt cttaattttg cattcaataa tctgactaga atatgcaata atttaaatgc 39420
cttgatggga gatagtggct tttagttctc ttgggatttc attgtaataa acctggtaaa 39480
taattcagga acatatgaga ggccaatgaa tggtcagcac ctggtgctat attatttgtg 39540
cctaagcaca cagactccaa agatggcact ctccacctgt cactgttgtt ctggcttaaa 39600
catgggccct gtgttcagtg gctattgaga taatagtaat ggatattttt gccttgtcca 39660
attttcctcc acaatcaaag aaaactgtgc taagctgttt aaaaaataca aagcagaagt 39720
ggcagcctct tttagattac cactggtaaa atttcaaatc tattttctct attaagggat 39780
tgattgtttt aaagaattag ggatatggct atcttttcta ctggtgctaa tttgagcctt 39840
tttgcctttc tgtctttgtt ccacaaggct gagcttctct ttagatcaca ttattcatat 39900
tgcaaggatc ttctgagaga aataacacca tcctctggcc agccactcac tctgcaggag 39960
ttcctagagc tccccagttt ctttccctat tgcctgagta gtctatctca cgcctgttag 40020
tctcacagtt taaatacaaa cacacaaaga ctcttgcagg cagcttgggt acctttcttt 40080
gaccccagcc gactggacat agagaacaag agctagagag aacaagagct agagtgaccg 40140
acagatcatg tgtggagaca gcatggggca cctgagccca gcaccatcca ggatcagaca 40200
gaacttaagc catgagctgc ctagaaagat cttgggaggg cactgggttt cccagtatgg 40260
aaaaaagaaa aatgtggctc acaagtctaa gctaaggtct ttacagtact gggccataaa 40320
caggatctga aaagaaactg cagaaaatgt tagatatgct ttatctttgt tttaaaaata 40380
ttatttacta taatggctta aaatatgttg atttaaatat atgatatttg atacctttgt 40440
aatatatata ataaagtgta taataaaata taactatata attaaaatag atgatatttt 40500
aaaacctctc taataaacca tttacgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 40560
tgtgtgtgtg tatacatgcc tttgtttaac aggtttaatt gctttccttt cttcaggaac 40620
cagagtgagg gtactcgaac agtgactgcc atctggtggt taaccagaat catcaccttg 40680
tgtagcctga tggttactaa gatgtccact cttgactcac atggcatgca ctcgcagcag 40740
gggaccagtt gaaggatgtc tgactttgga gggtcaccag ttgaaggatg tctgatgaag 40800
gagcctagcg aaataaccct ttgcttctac ctgaatgggt tgttcactct ggattctgag 40860
cctgcagcca gctccaaaat ggggcctctg aagaaaagat ttgagttgct cttgtgtctt 40920
agtcaaagat ctacatccct accagtgggt aaccaagact gtgaataagc acacaccaac 40980
aggggcatgt ggtgacatgg agcctgaaat aaactgctct gaattgtgtg acagttttcc 41040
tggccaggag ctggatcgga gaccccttca tgatctctgc aagacaacaa ttgtaagtga 41100
gcagccacag gatgccaggg ctgctcagat gtatgtggtg gtggtggtgt tggggaggag 41160
gaggtggagg gaaaggggga tgaggaaggg gaggagtggg aggagaaact gctcatgcag 41220
gatacatatt tcccagcact tggtgacgat ggggcagttt gtttttgacc tatagaagat 41280
ccttcattcc taacagctcc tccttattct gtcctcagac atcttcccac cacagcagta 41340
agaccatctc ttcattatct cctgtcctct tgggtattgt ttggactttt ctcagctgtg 41400
gacttctgct gatacttttc tttcttgcct ttacaattca ctgcaggaag aacaggtaag 41460
cagcccagtt tctcatcaca catagctcaa tcatgaaatc ccaaatgtta gtatcttttg 41520
gcagcacaag ccactatctg gtctcccact acaggattaa accacatgag acattccctc 41580
tgaaatagtc tacctgttga gaaggggaaa gatctaggtc ggtattgtgc taactactgc 41640
aagggtatcc aaagaagaga atgaagagtc tctctctata atggaggtac aatccttctg 41700
agaagatgag gtatctgtat ttaaaatgaa gaccatgtag aggattccaa aacaacacaa 41760
aaacttgagg acagcacagc agaaccagtc tgggtgagtt agggtttctg caaaagcagt 41820
gaagcactgc tacctggcta tttgctagat aattctggct gactagaaag tcatcagctt 41880
atcagggtaa gtatggctcc caggattcgc aaaagaagca aaatggtgac ttttttctga 41940
agggacttat agcaccttgc cttggatgca atttcatcct tcctcagggc ccatcccatc 42000
tctcccaccc ccacactgta ccctcatcct accacagccg tcccagggtg cctcatgaga 42060
agccctgctc cagccctctc cttagcccac agctgacttc tagatggagc ccacaatcag 42120
aaattaacaa cttcctcaaa ccagccaaac tcgtccagcc ccactccagc cttaccctgt 42180
gtggtgacca agcatgtcgt gctccattgc ctgtggattt gacactcaga tgagaattgg 42240
tcagttgcat tttgggatgc tgttttgcca tgttaggcat ggaggacgtg gaattgttaa 42300
gcagcagtga ttggttgttg ggtcagcctc agcatggtgg tgatacgtgg cactccaact 42360
agagtatacc ccagagactg cctcagccac ttttcattct gttcctcaag cacactacgc 42420
tgactcccat ctcaaggctt ttgtacttac tgttcctgta ctgttccctc tgcctggaag 42480
tcctcctcag atattcccat gactagttcc ttctcatctt ataggtcttg gctccagtgt 42540
cacctcttca gagacacctt ccctgatcat cctatctaaa gtagtatccc tacccatgat 42600
caccccctca tctcattcca tatcctatca gcctgtttta tgttccttat agcaagcata 42660
gtctgctatt accatatttg ttgatttacc tgttgattgt ctgtatcccc taccagaatg 42720
gaattctgtg aacacaggga ctttgcctgt cctcttgtgc ccaccactgt gtctccagca 42780
tttagaacag actctgggat ataataggtg ctcagtaaat atgcatccag tgatcctggg 42840
aggaaagaga tttaaatccc aacggtggct gctgccaaca aagtgactgg gaaaatcatg 42900
catttcaagg ttagagaact atggagtaca gtcttttcag ctgtaacatg tttctataat 42960
gcaaagtaat actcaattgg tattacccag ttggtaataa gaaaattatg tcattgattc 43020
atatgttact tttcccccag caaatcaata atttaaacat tcaggggcaa gctttctcac 43080
agctagtaaa ggaagcttta agcttggcag ttccttccct tggtgcaagt agtgtctggc 43140
ttaatggctt aagaacttgt gtcttcccta caagatgagg ctgtaggagt agatgaagaa 43200
gtggagaaga catttgcctt atgtttaaaa acttcagttg attgttaaag aaagcacaga 43260
tccagagcag atttttaatt ttttgacaat gttatctact ggagatgaat gcccctgagg 43320
acctgtgtct tgagatttaa gactgtagaa gttgactttg atcctgggta caaatgctag 43380
tggacattta ctgggtggta gtgttttagt tggaataatt aatattttat taatactctt 43440
gttacaaagt taactgtttt gagtgttatg accccatcct attttcccca cagtctatta 43500
tttttacata taattttgca gaatacaagg tttatcaagt atttatatat cctgttaaaa 43560
caggaacacc tgtaaacagc attatactag aaacccttat atttctttca ctctattaaa 43620
tattttgctg cctgttttgt ttgcagtggg agcatgactt ggcataaaga ataaaatatt 43680
aagaggtatt gtgaataaaa acacatttta caattaagtg gcttacaagg tcagacaagg 43740
aaagataaaa taacccagtt tcaaaagtgt tttattgaac aatacatttg ttaaaagatg 43800
cagcatcaca atcagatgct ttatttcgtt acaattctgt ggtctctaaa tttgggactg 43860
tgtgtgtgag tattcatgtg tgtgtatatg caagaaagga gaggaagaaa aatattttaa 43920
cacaataaaa ataatacaaa aatgtttaaa tccagttgca gatattgaat ttttataaaa 43980
atttcaaaaa ccagtaaaga taaagaaaac ttgaacacta tcaaccaact tgacccaatt 44040
gacatttata ttacctttca cccaacaaca gcagaataca tattcttttg aagtacacat 44100
ggaacattta ccaagatata tcatattctg ggccatagaa aaagtctcat taaatttaaa 44160
agggttcaag ccgggtgcag tggctcatgc ctgtgatccc agcactttgg gaagctgagg 44220
cggatagatc accagaggtc agcagtttga gaccagcctg gccaacatgg tgaaaaccca 44280
tctctactaa aaatacaaaa attagatggg tgtggtggca tgcacctgta gtcccagcta 44340
cttgggaggc tgaggcagga gaacccggga ggcagaggtt gcagtgagct gagatcatgc 44400
cactgcactc cagcctgggt aacagagcaa gactctgtct caaaaaaaaa aaaaattaaa 44460
ggattcaagt catataaact atgttttctg acaatgaaat taaaatggaa atcaataaca 44520
gaaagatctc tggaaaatcc tgaaatattt agaaactaca tagaacactt taatccatgg 44580
tcaaaaaaga aatcaaaagg aaaactagaa aatattgacc agaattaaaa tgaaaataca 44640
acctagattt gttggatgcc actaaagcag tattaggggg aaatctagag aactaaaccc 44700
catattagaa aagaagaaat gtctcaaatc catgacctca tcttccacct tacaaacaga 44760
aaaaaagagc aaatgagacc caaagtaagt agaagaaagg aaataataaa gatcaggtta 44820
gaaaataaaa taggaaacag aaaacaatag gaaaaaaaag tcagtaaagc caaaagctat 44880
gaagataagt aaaactgatc aacctctagc caaagtgatc agaaaaaaaa gaaataagat 44940
acaattaccc aaataaggaa tgggagaggt gacatcacta tagattctgt agatatgacg 45000
gataaggtaa tgttgtaaac aactatggta gatagcctct aagatgttct tcgatgattc 45060
ccacctcctt gtagtcacac tcctatgaag tcctctctcc ttgagtatga ggtgaactta 45120
ctaacttgct ttttagtgag atgtcgcttt tggcattagt tcacaaaaac tgtggcttcc 45180
accttagagc tctctcattg tcccactaac tcccactctg tgggaggcca gctgttgtgt 45240
tataagctgt cctgtaaaga ggcccccatt ggcaaggaac tgatgtttcc agcctgcagc 45300
cagcaagtac ctggggcttg ctaacagcca tgtcagtgaa ctttgaaaca ggtgacacct 45360
tgactgtatt gttgtgacac cttgactgta ttcttatgtg aaaacctgag ccacaggcac 45420
ccaactaagc tgtgacttag aaatattacc agttcaactt caaactcttc taaaaaaact 45480
gaaaataaag aagtaattcc caactcattc tatgagggca gtattaccct gatttcaaaa 45540
ttgaatagga aaaagaagaa ggagaaggag aagaaggaga aggagaagga agaggaggag 45600
gagaaggaga aggaggagga ggaggaggag gagaagaagg agaaggagaa gaagaagaag 45660
aagaggaaga ggaagaggag gaagaagaag aagaagaagg gaggaggaaa gctataggct 45720
aatatgtcct ataaacatag attcaaaatt ttaaacaaaa ttttaacaaa ttgagtatca 45780
ccaaatgtta aaaagagaat acatcattgt gacaacgtga ggtttatccc tggaatgtaa 45840
gctttgttta atatctaaag attgatcaat aactcatgac atttaccaac taaaaaagaa 45900
aactatatga tcatctcagt agatacagaa aaatttttga caaacttcaa catcaatttc 45960
tgataaagtc tcaacaaaca gcatagaaca gaacttcctc cccattgcgc agcacagctg 46020
ctgtggcaga ttgtggccag actgcttctt taagtgggac cccgatccat cccccctcac 46080
tgggcaggac ctccttgtga gaatttcagc aactccagcc agggttttat ggacagaact 46140
ctgatctctc tgggacagag cccctcaggg gaagggtggc cacagtctct gtggttcagc 46200
caacttagcc tttcctgcct gctggctctg gagagtctgg gcagtctgga caaaagggga 46260
tccccccagt gcagtgcacc cagtccccca aggggcagcc agactgcttc ttgaggcagg 46320
tccctgatcc cattcctcct gactgggtga gaactcccaa agggatcccc agacacctct 46380
tacaggagtg tttgggccag cgtcagtttg gagcaggcag ccatctttgc tgttttgcac 46440
cctttgctgg tgatagtgat acctccaggt gcagaaggga cccaggtgat tagggtctgg 46500
ggtggaccac tagcaaacca cagcagccct gcagaagagg agcctgactg ttaaaagaaa 46560
aacaaagcag caacaacaac ataaacaaaa aagatcccca aaaaaaccca ttgaaaggtc 46620
agcaacctca aagactgaag gtagataagc ccacaaagat aagaaagaat caatgcaaaa 46680
atgctgaaaa ctcaaaaagc cagagtgcct cttctccaaa tgattgtaat acctctccag 46740
caagggcaca gaactgggct gagactgaga tggctgaatt gacagaagta gccttcagaa 46800
tgagggtaat aacgaacttt gctgagctaa aggaacatgt tctaacccaa tgcaaagaag 46860
ctaagaatca tgataaaaca ttacaggagc tgataaccag aatagccagt ttagagagga 46920
acataaaaca cctaatggag ctgagaatca caacgtgaga acgtcacaat ccaatcacta 46980
gtgtctatag ctgagtagac caagcagcag aaagaatctc agagcttgaa aactgtcttt 47040
ctgaaataag acaggcagac aagaatagag aaaaaagaat gaaaacaaac aaaacctcca 47100
agaaatatgg gattacgtaa aaagaccaaa cctacaactg attggagtac ctgaaagaga 47160
tggggagaat ggaaccaaat tggaaaacat acttcataat gtcatccagg agaacctcgc 47220
caatctagca agacaggcca acattcaaat tcaggaaatg tggagaaccc cagtaagata 47280
ctccacaaga agatcaaccc caaaacacat aatcatcaga ttacccaagg tcaaaatgaa 47340
agaaaaaatg ttaagggcag ccagagagaa aggccaggtc atctacaaag ggaagcccat 47400
cagactaaca gtggacctct cagcagaaat cctagaagcc aaagaaactg gaggccaata 47460
ttcaacaatt tttttatttt ttgttttttt gagactgagt ctcgctctgt cacccaggct 47520
ggagtgcagt ggcgcgatct cagctcactg caagctccgc ctcccgggtt cacgccattc 47580
tcctgcctca gcctcccgaa tagctgggac tacaggcgcc cgccaccgcg cccagctaat 47640
tttttgtatt tttagtagag acggggtttc actgtgttag ctaggatggt ctcgatctcc 47700
tgacctcgtg atctgcccac ctcggcctcc caaagtgctg ggattacagg cgtgagccac 47760
tgcgcccggc ctcaacattc ttaaagaaaa gaatttccaa cccagaattt catatcaggc 47820
caaattaagc ttcataagtg aagaagaaat aagatccttt tcagacaagc aaatgctgag 47880
ggaattgtta caaccaggac tgccctgcaa gtgctcctgc aggaagcact aaatatggaa 47940
agaaaaaact taccagccac cacaaaaaca cactgaagta cacagaccag tgacactatg 48000
aaggaaccac ataagcaagt tggcaaaata aacagctagc gtcatgatga caggatcaaa 48060
ttcacacata acaacactaa ccttaaatgt aaatgggcta aatgccccca ttaaaagaca 48120
gagaatggca agctggccaa agagcaaaga cccgtcagca tcagcaaaca cccagatgct 48180
gtcttccaga gacccatctc aagtgcagag acacacatag gttcaaaata aaggaatgga 48240
ggaaaattta ccaagcaaac ggaaaacaga aaaaagcaag ggttgcagtc ctagtttctg 48300
acaaaacaga ctttaaacca acaaagataa aatagacaag ggcattccat aatggtaaaa 48360
ggctcaattc aacaagtagc gctaagtatc ctaaatacat atgcacctaa tatgggaaca 48420
accagactca taaagcaagt tcttagagcc ctacaaagag acttagactc ccacacaata 48480
atagtgaaag actttaacac tccactgaca atattagaca gatcattgag acagaaaatt 48540
aacaaagata ttcaggacct gaactaaact ctagattgaa tggacctgat agttatctac 48600
agaactctcc acccaaaaac aacagaatat acattctttt catagccaca tggcactcta 48660
aaattgatca tataatcaga agtaaaacac tcctcagcaa atgcaaaaga actgaaatca 48720
taacaaacag tctctccaac cacagcacaa tcaaattaga actcaagaat aagaaattca 48780
ctcaaaacca tacaactaca tggaaatgaa caacctgctc ctgaatgact cctgggtgaa 48840
taatgaaatt aaggcagaaa tcaagaagtt ccttgaaact agtgacaaca aagagacagt 48900
gtaccagaat ctctgggaca cagcgaaagc tgtgttgaga gaaatttata gcactaaatg 48960
cccacatcaa aaagctagaa agatctcaaa tcaacaacct aacatcacaa ctaaaaaaac 49020
tagacaacca agagcaaaca aatcccaaag ctagcagaag acaagaaata accaagattg 49080
gagtggaact gaaggagata gagacacaaa aaaaaatttc aaaaaaccaa caaatccagg 49140
agctgatttt ttttgaaaaa aaaaaagtta ataaaataga ctgttaccta aactaataaa 49200
gaagaaagag aagaatcaaa tagacacaat gacaaatgat aggggggata tcaccactga 49260
cctcacagat acaaacaacc atcagagaat gctataaaca cctctatgca cataaactag 49320
aaaatctaga aggaatgggt aaattcctgg gcacaaacac ttgcccaaga ctgaaccagg 49380
aagaaattga atccctgaat agaccaataa tgagttctga aattcaggca gtaacaaata 49440
gcctagcaac caaaaaaagc ccaggaacag acgaatttac agctaaattc taccagaggt 49500
acaaagagga gctggtacca tttcttctga cactatttca aacaattgaa aaggagggac 49560
tcctccctaa ctcattctat gagaccaaca tcatcctgat accaaaacct ggcagagaca 49620
caataaaaaa acaaaacctc ggacaaatat ccctgatgaa catcaataca aaaatcctca 49680
ataaaatact ggcaaaccaa atccagcagc acatcaaaaa gcttatccac cacgatcaag 49740
ttgacttcat ccctgagatt caaggttggt tcaacatatg caaatcaata aacgtaactc 49800
atcacataaa ccacatgatt atctcgatag acacagaaaa ggcctttgat aaagttcaac 49860
atctcttcaa taaactctca ataaactaag tattgaggaa tatacctaaa aataacaaga 49920
accatctatg acaaacccac agccagtatc atactaagta ggcaaaagct ggaagcattc 49980
cccctgaaaa ctggcacaag acaaggatgg cgtctctcac cacttttatt caacctagta 50040
ttggaagttc tggccagggc aatcaggcaa gagaaagaaa taaagtgtat ctaaatagga 50100
agagaagaag tcaaactgtc tttgtttgca gatgacatga tcctatgtct agaaaacccc 50160
atcgtctcag cccaaaacct tcttaagctg ataagcaact tcagcaaagt ctcaggatac 50220
aaaatcaatg tgcaaaaatt gctaacattc ctataaacca acaacaggca agcagagagc 50280
caaatcatga atgaactccc attcacagtt gctacaaaga ataaaatacc taggaataca 50340
gctaacaagg gaagtgcagg gcctcttcaa ggagaactgc aaaccactgc tcaaggaaat 50400
cagagaggac acaagcaaat ggaaaaacat ttcatgctca tggataggta gaatcaatat 50460
tgtgaaaatg gccatatggc ccaaagaaat ttatagattg aatgctattc ctattaaact 50520
accattgaca ttcttcacag aattagaaaa aactattata aaattcatat ggaaccaaaa 50580
aacagcccca atagccccaa tatctttttg cttaggattc taagcaaaaa gaataaagct 50640
ggaggcatca tgctacctga catcagactg tagtacaaga ctacggtaaa caaaacctca 50700
tggtactggt acaaaaacag atacatagac caatggaaca gaatagagaa ctcagaaata 50760
agaccacaca cctacaaaca tctgatattc aacaaatctg acaaaaatga gcaatgggga 50820
aaggactccc tatttaataa atggtgctgc aaaaactggc tagccatatg tagaaaattg 50880
aaagtggacc ccttccttac accgtataca aaaattaact caagatggat taaagactta 50940
aatgtaaaac ccaaaactgt aaaatcccta gacgaaaatc taggcaatac cattcaggac 51000
atagacattt catgacgaaa atgccaaaag caattgcaac aaaaccaaaa attggcaaat 51060
ggggtctaat taaagagctt ctgcacagca aaagaaactg tcatcagagt gaacagacaa 51120
cctgcagaat gggagaaaat ttttgcaatc tatccatctg acaaaggtat aatatccaga 51180
atctacaagg aacttcaaca aatttacaag aaaaaaataa ccccattaaa aagtgggcaa 51240
agggcatgaa cagtcacttc tcaaaagaag acatacatgc agccagcaaa catgaaaaaa 51300
agctcaacat cacagatcat aagagaaatg caaatcaaaa ccacaataag aggtgggtgg 51360
gtcacttgag gtcaggagtt caagactaga tctagaatca gaaataccat ttgacccagc 51420
agtcttatta cggggtatat acccaggaat ataaatcatt ctattataaa gatacatgca 51480
tgcataactt cactgcagga ctattcacaa taacagagac atggaatgaa cccaaatgcc 51540
catcaatgat agactggata aagaaaatgt ggtacatata taccgtggaa tactatgcag 51600
ccataaaaag gaataagatc atgtcctttg cagggacctg gatggagcaa actaatgcag 51660
gaacagaaaa ccaaacactg catgttctca cttataagtg ggagctgaac tatgagaaca 51720
catagacaca tatggggaga acaacacaca ctggggcctg ttggggaagg ttgggggagg 51780
gagagcataa ggaagaacaa ctaatggatg ctgggcttaa tacctaggtg atgggttgat 51840
ctgtgcagca aaccacctgg cacatgttta cctatgtaac aaacctgcac aggtaccctg 51900
gaacttaaaa gttaaaaaaa ttttaaaaag aagagaactt cctcaacctg ataatgtgca 51960
tctataaaaa aacctatacc taacatcatt tttaatggta aaagaccgaa tcctttccca 52020
ttaggatcag aaagaagaca agatatccac tctcacgact tctattcaac actggaggtt 52080
ttagccagtg caataaggta agaaaaataa acaaaagtca cctacttttt aaaaaaagta 52140
agaatgaaaa tatttttacc ctcagatgac ctgatcacct atgtagaaaa tccagtgaaa 52200
catttaaaag gaagaaacag ggcaggcatg gtagctcacc cacccaaagt gtaatcccac 52260
cactttggga agctgagaca gaaggatcac ttgaggtcag gagttcaaaa ccagcctggg 52320
cacagagtga gaccttgtct ctataaaaaa ttaaaaaatt agctgggcat ggtggtgcat 52380
agctttagac ccaaacactt agaaggctga ggtgggagga ttgcttgaat ccaggagctt 52440
gaggctacag tgagctaaga ttgtgccact gcactccaaa ctgggtgaca gagccagacc 52500
ctatctctaa acaaaacaaa actactagaa ctaatacatg agtttagcaa ggttgcagga 52560
tacaagatca atgtacaaca ctcaactgta tttccatata ctaacaacaa ataattgaaa 52620
aagtgaaatt aaaagcaata ccatttacaa cagcatcaaa tagatgaaat atttagggat 52680
aacctaacaa acaatgtgaa atgcctgtac actgaaaact ttaaaacatt gctaagagaa 52740
tttttaaaaa tctaaataaa tggagataca ttgtgttgct gggttggaag actcaatatt 52800
gtttaaatgt cagttcttcc ctagttgatt tatagactta atccaataac agtcacattt 52860
cctttttttg tataaattga caaactgatt ataaaattca tgtgaaaata tgaaggacct 52920
agaatagaca aaacaacttt taaaaagaat gaagttggaa gactaggacc acctgatttc 52980
aagacatatt acaaaactaa cagtaatgca gacagtttgg tactgggcaa ggatagacat 53040
attcatcaac agaacagaat agactacaga aataaatcca catgtatatg gtcaactgat 53100
tttcaacaaa ggtacaaagg caattcagtg gagaagggac agtcttttca gcaaatactg 53160
ctggaacaaa tgtatatcca tatgcaaaaa tgaactttga tctagctaca tgttacacca 53220
tattaagaaa ttaactcaaa atggatcaca gacctattta taaaacctaa acctgtaaag 53280
tttataaaag aaaacatata agaaaaattt tgtgaccttg gaataagcaa atatttctta 53340
ggtacaatac caaaagcatg gtccataaaa gaaaacactg atgaattaga ctttttaatc 53400
attaagaaca tcttctcttt caaagagaat cttaagagaa tgagaaaaag ccacagacta 53460
gaataaaata tttgaaatca tatatctggc tgggtgtggt ggctcacgcc tgtaatccca 53520
gcactttagg aggttgaggt gggtggatca cctgaggtca ggagttcaag accagcctgg 53580
ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa aaaatgagcc atgcgtggtg 53640
gaggcacctg taatcgtagc tactcaggag gctgaggcag gagaattgct tgaactcagg 53700
aagcagaggt tgcagtgagc caagattgct ccattgcact ccagcctggg tgacaacagt 53760
gaaactccat ctcaaaaaaa aaagaaaaaa aaaaactcta aaaacgcaat acagtggtgc 53820
tcccttatct gtggttttgc tttccatggt ttcagttacc tgtggtcaac catggcctga 53880
aaatattaaa tggaatattc cagaaataac caattcatag gttttaaatt gtacaccttt 53940
ctgaggagca tggtgaaatc tcatgctgtt ccactctggc ccacccagga cacaaatact 54000
ccttttgtcc aacatatcca tgccatatac actacctgcc tgttagtctc ttagtagcca 54060
tcttgattat cagattgcct gtcatggtat tgaagtgctt tgtgttcaag taacccttat 54120
tttgcggtgg ccccaaagtt caagagtaat gatgctgaca tattgttata atttggtatg 54180
gtttggctct gtgtccccac ccaaatctca tctcaaattg taatcctcac atgtcaaggg 54240
agggacctgg tggaaggtga ttgggtgatg ggggcagttt ccctcatgct gttctcatga 54300
tagtgaggga gttctcacaa gatctggttg tttgttaagt gtctggccct ttcccctgca 54360
cactctctct ctcctgccac cttgtgaaag tgtgtcttgc ttcccctttg cctttcgcca 54420
ttattgtaag tttcctgagg cctccccagc catgcagaac tgtgagtcaa ttaaacctgt 54480
ttttctttat aaattattca gtctcatgta gtacctttat agcagtgtga gaacagacta 54540
atacataatt gttttattat tagttatggt tgccaatccc ttactgtgcc taatttataa 54600
attaaacttt attataggta tatatgtata agaaaaatca gtatatatgg ggctcagtac 54660
tatccatggt ttcaggcatc cactgggggt cttggaatgt atcccccctc agataagggg 54720
gactattgta ataagaaaac aattcaatat tttaaaatgg gtaaaagatt tcaacagata 54780
cttcaccaaa gaagatatat ggatgacaaa taagcatatg aaaagatgtc caataccatt 54840
actcattaag gaaatgcaaa ttaaaactac attaaaatac cactacacac tcattagaat 54900
ggctaaaatt aaaaagactg agtaaatccc atgttggcac acactgctga ggagaacata 54960
atttggtcca accacttcac tttggaaggc agtctgggag attatttatt tatttattcc 55020
attcctggct gatttttttt atagaaatag agtttcacta tgttcctcag gttggtctca 55080
aactcctggg ctgaagcaat ctgcctgtct tggcctctca aagtgctagc attgcaggca 55140
tgagccaccg cgcccggcca tggcagtttc tttaaaagtt cagcatatac ctatgatgtg 55200
atctagctat gccactctta ggtttttacc caagagaaat gaaactgcat gtccatacaa 55260
agacttgtac gccaatgttc atagcaactt tctttgtaat agccaaaaac tggaaatagc 55320
acaaataccc attagcaagt gaatggctaa acaaattgta gtatatccat acaatagaat 55380
cctgctcagc aatttaaaac atgaattatt gatacttgga agaacaaaga tgaatctcaa 55440
aataattaca ctgaatgaaa gaagccaggc aaaatgacta catgctatgt aaatccaatt 55500
ccacaaagtt ctataaaact aaactaatct attgttaact aatctgtagt gacagaagca 55560
gatcagtcgt tgcctgtgga tgagtagggt tggcaaagag tcaggaaagg aggatgacaa 55620
aggggcatgt ggaagctttt tggggtgatg gatatgttta taccttgatt atggtatttc 55680
acaggtgcat acatatatca aaacttatca aatcatgtac tttaaatatg tatgtcatgc 55740
actttaaatt gtgtgccagt tataccttaa taaagctagt aaaactatta tacattctta 55800
tttttctgag caggttctca tggagaacaa aatacaccat acctagtgtt cgttttcttt 55860
tttttaatta attaattaat tgatttttat tagtgttcat ttcaaaggac cttgctaggt 55920
gtcctaaaac ctatctgatg actttgcctg atactgatga ttttattatg attttaaaaa 55980
atatttttag tagagacggg ttttcgccat gttgggcagg ctggtctcga actcctgacc 56040
tcaagtgatc ttcccacctc agcctcccaa agtgctggga ttacaggagt gagccaccat 56100
gctcagccaa tactaataat tgatatggga gaatgttttg tttttcctag attcctcatg 56160
cagcttaata aggaccataa taacttaact cttagaacaa aggagatatt tcaggcccaa 56220
agggaagcac atctggtgcc tcctctgaaa ttcacaaaat aagggcgttg ttgtaagttc 56280
tgcatgaagc taaacttgtt caaagtttat aagttcaaaa gtaaataaaa ggactatctt 56340
ttattctgag accttatttc aatatcactt gtgataatga ttatagatcg tagctgttat 56400
ttacatattg ctacttctca gggttaaagg tggcatttcc acagcagtat ctgggatttt 56460
attgcctatg aaatcaagaa ggtagagtaa caagaattgt gtagggtatg agcttttacc 56520
ttacatgcaa gttaacaagt tagcctggta atgtttgatg gatgttagct aaagacatga 56580
gactcttggg tcagagaaaa aacacttgat tactcatggc aaaagcagta atcagaactt 56640
aatattgagc ttttactggt ttccatgccc cacgtgccat gaggggaatg aaagtcccat 56700
aatggatgtt tatggatgtt tgcacacaca cagtgggcta ccatttaagg agaggaatcc 56760
tgagcctggt aagtccactg cttttatagt gagttgtaac aagcctgttc tttgtctagg 56820
ggaagatgtt acctgatccc tcaaggttgc tcattacaaa cacaaccctg agaaatggcc 56880
tggataaaga gcagtcagag ccttgcttct tggcatacct gacaagaatg cacagagctg 56940
ctcagggccc ctggtaggtt tgcctcccac actagggact gtgcatggag gcacctgcca 57000
cttctgcctg catcctgggc tagcgtgaca gtcagagaca cagacaccag tgaatggctg 57060
aaatatgttc ctgtggtctt ctcactccac tacaacttcc ttcccagtta gggtccccat 57120
gcaggccctt tgagctgcac ctggcagagt tgagttacat actttcatgt accctgctga 57180
gtttgtcttc tttgccttca gaaattccaa catactacat gagtcatggt tcttggtatt 57240
attgttatac ccttctcaga atctctctga ctccccagat ttcacatcgt tttccatttt 57300
tgtaaaaggc ctcaaggtct ccatgctatg gagaagagtt atactcatct tttctttatt 57360
cttgcattcc tgaaagcctt acattagcat ccaagtgagg tttctctatc aatatcaaca 57420
gtaaatattt agtgaactaa acacctacta tgctcagcat aatgtataaa atatgattta 57480
agggttcctg ggagcttcaa atgcatcacc tgggtgcaaa aacatgagga aaccaaaaag 57540
tacattctgg tggttttttt aatagcattt aaaaaataat gccttgctgc agggatagga 57600
gctgtgctgc tttcatatca attctgttct ctttgtggtt tgagaaactg gagctgaagg 57660
gaaggtgatt gggaataaaa gaaagcagta ctgatttttc tggctaaaag aaagtttgca 57720
cactgtcatg cactattaga atttctggga tcttctttat aatccccggt ttgatggtta 57780
ttggccaaga aggaagaagg ggagctagtc aggcctagaa taattaccag ccatacagca 57840
taatctgggg ctagtgttgc agggtcaagg actgaatgag gcagagtgac caggagcaga 57900
tcctgcaagg ccttgaccaa aaaggaagct aaggttcata gaaggaaaat attgtattga 57960
tcatcaattc tagaggattg ggcatagagc caaaaatagg aggtgtatca tgagatcaaa 58020
agccattggt ggccaagcgc gatggctcac acctataatc ccagcacttt gggaggccaa 58080
ggcgagcaga tcacttgagg ccaggagttc aagaccagcc tggccaacat ggcaaaaccc 58140
tgtctctacc aaaaatataa aaattagctg gccatggtgg cacatgcatg taatcccagt 58200
actcaggagg ctgaggcagg agaatcactt gaacctggga ggcggaggtt gcagtgagcc 58260
gagatcatgc cactgtactc caacctgagt gacagagtga gaccctgtct caaaaaaaaa 58320
aaaagccact ggtatgtagg aatggtgcag gaaaaaagtg caaagcagaa atgaggtgaa 58380
aatatataga actatgaaca ggaatgaggt ctttcttgag tactggctgc cagatggagt 58440
acgagtgggt cagcagaagt taatgaggta ggttaaaagt taatgcatag gaatagtttc 58500
tgcacagtct tctgatgctg tccatcctgc agtcaggcct atatcaatat cagccctaga 58560
tgaagtggtc acaccctcct ttgtgcacct actgttacaa atagtcatgg ctgtcattac 58620
tccatcacag ctgatggcac ttactaggtt gagagaagcg gggctctgtc tcccttacca 58680
tacagtgagc tccttgagtt tattcatctt tgtgtttcca ttgtgcctgg actgcgcact 58740
gtttcccgaa tgaacaaatt aactggccta gaatatatct atgatgataa aggtcagttc 58800
ttagattatt gttttcattc tttaactgtt taagataatg tcaactctat gtaaaaattg 58860
tgccctaggt aagcagttgc tttttattat tattctctct ctttcttgat ggttactccc 58920
tctaggagcc caaagcatga cgtccagagc cccagattcc cagccatcct ggttgtgacc 58980
cttcattctc aactttcatt tcaatcttag tatgccatga aaagccgtct gcttttgaag 59040
cactatcagc cacagagttc tgtactttta gaaggccttc tcatagtcag attctcacaa 59100
atatacctat tgtttcaata aatatttatt gaattggcca gcaatgtttc agatactgtt 59160
ctaggtgctg gggttacatc aaagaacaag gtaggcaaaa tcactaccct cgtggacttt 59220
gctttcctgg agggggaata ggcaggacat aaaataaatt gtaaactatt cgggatgtta 59280
gtgatcagag aagaaaagta aaacagggac agtgaatggg gactgtcaga gtggtagttg 59340
ctattcaaga tcatttgacc aaggaaggcc tcgctgagga agtaacattt gagaatagac 59400
ttgaaaggca taaaaaaaca agtcattagg taaaaaccat tccaggcaga aggaacaaat 59460
aatgcaaagg gccagggatg gaaacatctg tagtgttcag gggaaagcaa ggaggccagt 59520
gtgactggag cagagtagat taggcaaaga acaggagtag ataagatcag caaggtaatg 59580
ggtgccacat cacgtaaggt cacacaggac agtgtaatga ctttggcttt tactctgtta 59640
tggggagcca ttgcaggatt gggagctgtg aaatggcaca ccttgcttac atctaatagg 59700
aaatctgctg ctgcattgag aatagacctt taaattttaa aagagatatc tatggcatta 59760
ccttaaataa agtcatgctc cttggagtgc ctcaattcat gtacattaat gggtaaaagt 59820
ggaattcaag aaaccctgga aatgtatggg ggagtcctct ttgtttctcc tctgctcatg 59880
tctggtgggt gagcactaac gccatctctt cctaagcgag ggctccctag cagagcaccg 59940
tgcacatgga ttcttcctat gctctgcatt ctttgccaca gggatgccat aatttggcaa 60000
tatgcagtag agactgcctc aagaggcagt tcccttcttt atctaagcca agagaaattt 60060
ggttctgcaa gtaacaagta attactgctg atgacattcc ttgtacacac ttgaagagag 60120
cgtggaccgc aaaataaaaa ctggagcaaa aagggactat cagataatcc agattaaaga 60180
ttggaaagga ggaaaacaca ttatttacac atacaacact tgattttatg agtagagaac 60240
acaacttatg tgtatgtacg ttgtacactt gattatatgt gtagagaatt caaaagtgtt 60300
cagataaatt atttagactt aaaaagagac aaataatttt gggaaggtga tagtggcagt 60360
agtagcatag gttttagata ttcctgaatc tccacataaa aacagcaact agatagaaga 60420
cacaaaactc atgggcaaca aaataaaatc catttacaag aaaattagat gatgaggtat 60480
tcttatgatc ctcaaaatat aaccggttgg ggaaagacca cccacagcca caagagctgt 60540
gttatttgtg tctacgtagg agaaataaga gagaggcaat ggacatctga cagacctgag 60600
aacagagaac tcaaaatagc ccaaaggtat tcactggaaa gcatgggtgg ggcaatttga 60660
gatcagcagc tgaaacttaa taaggggtga gtgcaaggga tccacctctg gaaggtctaa 60720
aaggaatgca gcagtctagc tgctgtgaaa tttctagact gatctggtgg ggctcccttc 60780
caagatagga tctcatgaag aagagaaact gtggggagta ttgagctcaa aattgagcag 60840
aatgaagaca atacagatga agaaggaaga ggaatatcca aatgaaagca tatcagagtc 60900
aggaaatctc cttggaaagc aagccagagt attttttaac accatattaa tacaatatag 60960
caaaggaacc atgtgaagtt agaaaagcta tctgaaccaa atgtcttttt aaaatcacat 61020
aaaaactaaa ttcacaccca caaaaatcta cagcaggaaa atatcaaggc caaatccaac 61080
acaacattat taacctaaga aagagaataa ggggaatatc tgcagacaat gaaagcatgc 61140
caaaaagata tgattgaaaa tagattgaga ccctaatgta ctatttcagg tgcattcaaa 61200
gacattgaag aagtcatata agacatagaa aagcaacata aatcaaatta ggaagctcag 61260
aaatgagaca attcaagaaa aaattagaaa taaacatcta aaaatgaagg ctgatctaga 61320
aggaactcaa caacaaatga atacaacata attctttaac ataaataaaa ggtagaaagg 61380
aagaaaattt tttaaatgga atgaaaaaag atttttaaaa agttttgaaa gaaaacaaca 61440
aatattgaaa ataggcaaaa aagatcaatt tatcaataat aagagtccct gaaaaagaaa 61500
ataaaagcaa ggaaagaaaa caagtataaa acaaacaaaa ccctctaatt taagaaaact 61560
gaaaatttga aactacgtat ggaaagaaca cactgtgtac ttgagtatat cataatgact 61620
aagttcagca gagttgttgg atgaaaggtc tatgtgtaaa caccatttta tgtaacattt 61680
aaacaaattt tttagatcat ttaaaacagc ataaaaaata taaaatccta tttgtgacgg 61740
ctttctagtg tgtcaacttg actaggccaa actacatttc ctagaattct ctttcttgta 61800
tgttttctga ccacaaagga gattctttct agatttggaa agctaaggga agttccagcc 61860
atcttatagc acacacattg ttgcgaacct gctgatccac ctactggggt gaagcagagc 61920
tggacatgca attgctctac cttcccctgg accctccatt aacttgtcag gcccctgggc 61980
caggtgtgtg tgattagctc cacgacaaag ggccacagct tctgcaggat atactcatta 62040
cctagatcag aggcaacaat aactgacatg ggtttcagtc tcttcacagg ggtgtgagca 62100
tgctctaatc tcttgatttt ccctcctgac tgcctgcctt gtagacttca agctctagca 62160
tcagatgtgg agacaacagc cttacagaga ctgcttaaag agctcccaaa attgcataac 62220
tcaactgcct gtgacacatc catatatctc tttttgaatc ctggctaata cagtaggaaa 62280
agatatgcat tatctctata tagaaaatca taaaatattt tgagaggaat taaattctat 62340
attcattgat cagaagactt aatattgtaa aaatatcatt tctccccaga ttgatatata 62400
ggttcaatgc aatagaaatt ccaacaactt gcatatgtgt gtgtgaaact tgacaagcta 62460
aatctcaaat ttatacggaa attcaaaggg ctaaaaatag gctggaaaga aaaggacaag 62520
ctgggcgcgg tggctcacgc ctgtaatccc agcacttttg gaggccaagg cgggcagatc 62580
acatgaggtc gggagttcga gaccagcctg gccaacatgg cgaaacaccc tctctactaa 62640
aaatacaaaa atttgccggg catggtgggg ggcgcttgta atcctagcta cttaggaggc 62700
tgaggcagga gaatcacttg aacccaggag gcagaggttg cagtaagcca agatggcacc 62760
attgcactcc agcctggatg ataagagtga aactctgtct aaaaaaaaaa aaaaaaaata 62820
ggacaaagtg agaggatttc ttcttctgga tatcaatatt tactataaag ctagtaatta 62880
aaacctgcta aatatggtat tggagcaagg agagacaaat agatcaatag aacagaatag 62940
agagaatcca gaaagagtca aggatatata gatgcttttc aataaatggt gcagggtcag 63000
ttggctatcc acatggagaa aaaagtgcaa cctgaatcca cctcaacaaa attacttcca 63060
ggtgaactac tgaaatggaa aacaaaaaaa cttcaggaaa gtcatagaag agagtatctt 63120
tatgaactag ggacatgaaa atatgttaaa cagaacacaa caagtattat tcataaggga 63180
aaatattgtt aaattgctct acattcgttc aggagcagcc tgggcaacat ggcaaaatgc 63240
cgtctctgct aaaaatacaa aaatacagcc aggcatcgtg gtgcatgcct gtggtcccag 63300
ctactctaga ggctgaggtg ggaggatcac tggagcctgg gaggcagagg tcacagtgag 63360
ctgagatcac gccattgcac tccagcctgg gtgggtgaca gaggaagacc ctgtctaaat 63420
tgaaaaaaaa aaaaaagctc tacattagaa attgagaact tctgttcatt aaggacatca 63480
ctaaggaaaa aggcaagcca tagactggga caatgtattc acaatgcata tgtcatcaaa 63540
gaatctttat tcagaataaa aaagtgggaa tctatatgaa aacatagaaa atccactttt 63600
ttaaaaatgt gcagtcttat gtttatcaca gcactgttca cagtagtaaa gtcatagaat 63660
ccatctaagt gtccatcaac agatgattgg attaaaatgt ggtatatttt tgccatggaa 63720
tactatacac ctataaaaat aaatgaaatt atgtcttttg cagcaatgtg gatggaactg 63780
gaagccatta tgcttactga aatgactcag aaacagaaaa tcaaaaacca catgttctga 63840
ttgataagtg ggagctaaac agtgggtata cacggacata caaggggcat aatagacact 63900
ggagactcca aatggtggga ggatgggagt gggtgaggga tgaaatacca cctttcaagt 63960
acagttcagg tgattggtac acttaatgcc cagatttcac cactgtgtaa tatatccatg 64020
taacagaact gcatttgtat ccctaaatcc ataaaaataa aaaaatttaa tttcaaaaaa 64080
taaaaaatgt gcaaaagata tgaacaggta catcacaaaa gaacaaatcc agatagccaa 64140
taaacaaatg aaaaagggct caacttcatt agtcatcaga gaaatgcaaa ttaaagccac 64200
agtgtgataa tactacatac tcacttgaat gtctgcaatt aaaaaaaaga ctgacaaaac 64260
caagtgttga gaaggatgta gaacaactgg aattctcatg catagtgtgg aagtgtgcat 64320
tgatacaatc acttttgaaa actgtttagc agtatctact aaacttgaac atattcatac 64380
cctgtgtcct agcaattcca gcaaaattgc atacatatat tcaccaaaat aatgcactag 64440
aatattcata gcaacactat ttgtaatagg cccaaattgt aaactgtttg aatgtccatc 64500
aacagttata atatctattt ataatgtcca atatatcaca gtatactcca tgccacaata 64560
tagatggctc tcacaaaaat aataaatagt gttgagcaaa ggaagccaga aaaagagatt 64620
ataccctatg ttactctttt tacatgatgc acaaaaacag gcagagctaa tctaagatgt 64680
tagaagtcag attgggtggg tggagaaaag ggagaataga gcaagaggaa gacttctgaa 64740
gcactaataa tatgtttttt gacttgcatg ctggttgccc aggtgtgtca gtttttgaaa 64800
attcagtgaa ttatacattt atatatatgc atttttgttt atgcatattt ttcttcagca 64860
aaagtttaaa aaataatctt tgggcttcct gaaaagataa aaaggaaacg tttaaaggat 64920
acatgtcaat tttttagcag agacaaaatt tttaaatact attttctgaa aaaaaattct 64980
ccctcacagc tttatattta ttattaatat tgaaggatat aatgaatagt tttactgtaa 65040
atgcagaagt aaattttata agacttgttt atggcaccat taggaatagt ttttaaaaat 65100
cagaacttgt gtttatcaaa agacactatt aaatgacacc aaaagcacaa gtaacaaaag 65160
aaaaatgtgt ttaatatcat caaaattaaa aatttctggc caggcaccgt ggctcacgcc 65220
tgtaatccca gtactttggg aggccgaggc aggcagatca caaggtcagg agtttgagac 65280
cagcctgacc aacacggtga aaccccatct ctactaaaaa tacaacaaat tagccaggca 65340
ttgtggtgcg cacctgtaat cccagctact tgggaggctg aggcaagaga atcgctcgaa 65400
cccaggaggt ggaggttgta gtgagcgaga tcttgccact gcactccagc ctgggtgaca 65460
gagcaagact ccacctcaaa aaaaaaaaaa aaaaaaaatt ctgtgcttca gataacacca 65520
ttaagaaagt aaaaagaacc tacagaatga agaaaacgtt ttcaaattat ataatagacc 65580
tgataaggga ctcacatcta gatatataaa gaatgcttac aactcaataa tacaaagaca 65640
aataaaacaa tttttaagtg ggcaaagaat ctgaatagaa gtatctcaaa aaagatatat 65700
gaatggccag taggcacatc attaccccta agggaaatca aaatcacaat gagttaccac 65760
tttgcatccc ctaagatggc tataatataa aaattaacaa gtgtttgtga ggctgtggag 65820
agattagaac cctcattcac tcctcctagg gatgtaaaat agtgtctgag ctagggaaat 65880
agtttggcag tttcccaaaa tgttaaacat agggttacca tatgactcag tgattaagct 65940
cctaggtata tactcaagaa aatcaaaaca tatgtccatg taaaaacttg tacatgaata 66000
ttgatagcag cattgtttat aatatcccta aaaggaaaca acccaaacat gtatcaacta 66060
ttgaatggat aagtgaaatg tgttatatcc atacagtgaa atattattca gcaattaaag 66120
tgacacactg actcatgcta ggacatggat gaaacttgaa aacatgatgt taggtgaaag 66180
aagctagtcg caaaagatca catttgattc catttatatg aaatgaccaa aatagacaaa 66240
tctataggga cagaaaggag attcgtggtt atatgtggct ggggaaatgc aaattaaaac 66300
tactaggaga tacataccga tggtatgtat gcttatcttt aaattatctt taaatttttt 66360
aagataataa gataaagatg tgaaactatg aaactctcat ttactcactg ggagggtata 66420
aactggtaca accacattag aaaagaaatt ggcgtatctt ttaagattaa caacacatat 66480
accttgagag ccagcaaatc catttctaaa ttctactcag tagaactatg tgcatattta 66540
tatcaatagg tgtacaaaaa tattcatagc agcattattg taatcaccca aatgttcatc 66600
agaagtataa ggaataaata aattgtggta tattcctgca atgggatatt atatagcagc 66660
tacagttaca cccagcaaca tgtataaatc tcacaaacaa catcaaataa aaaagccaac 66720
cacaaagtag catccactat gattcccatt tatgaagttt aaaaacaggc ataactcaac 66780
tatagtatta aaagtcaata tagtagttca ccttaaggga gaagggaaag agtaaaaagt 66840
ataatatgag gtagaatttt gaggtattgt aatgttctct ttcttgggtt atagttttct 66900
atatgatgtt ttctttgtta caatttactg agctatacat ttttaatttg tacacttaaa 66960
aatacatttc ctggccaggc gtggtggctc gtgcctgtaa tcccagcact ttgggaggct 67020
gaggcaggca gatcaggaga ttgagaccat cctggctaac acagtgaaac cctgtctcta 67080
ctaaaaatac acaacaaaaa ttagccaggc gtggtggcgg gcacctgtag tcccagctac 67140
tcaggaggct gaggcaggag aatggcgtga acctaggagg cggagcttgc agtgagccga 67200
gattgcacca ctgcacttca gcctgggtga cagagcaaga ttctttcaaa aaaaaaatat 67260
atatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtatgtgt gtgtgtgtgt gtctgtgtgt 67320
gtgtgtgtgt attctggccc aagattatag ttttttttaa ggcagtctgt caggggtcta 67380
caattgtatg agttataaat aaggagtgac aatatcttca gtgaactcct gaacatgaaa 67440
accaagggtc gactgcgaat accttcttta catacaacca gacattatgg aatgaatgtg 67500
ttccccccaa attcatatgt tgaagctcta actcccagtg tgtctgtatt tggagatagg 67560
gtctttgggg aagtaattaa agttaaatta ggtcatacaa cctacagaat tggagaaaat 67620
atttgcaaac tgtgcatctg acaatggtct aatacccagc atctataaga aacttaaatt 67680
tacaagaaaa aactaacaac cctatgaaaa agtgggcaga gttaattttt tcatgagcaa 67740
tggaaaaaaa ttaaaaagtc tgaaagcagg caaagaacat gaacagacac ttttcaaaag 67800
aagacataca tgcagccaac aggcatatga aaaaaagctt agtatcactg atcattagag 67860
aaatgcaaat caaaaccaca atgagatacc atctcacacc aattggaatg gctactatta 67920
aaaagtcaaa aaataacatg ctggcaagat cgcagagaaa aatgaacaca tacactgttg 67980
gtaggagagt aaattagttc aacattgtgg aaagcagtgt ggcgactcct caaagagcta 68040
aaaacagaac taccattcac cagcaattcc atttgtggtt gtatacccaa aggagtataa 68100
atcattctac cataaagacg caggcacatg aatgttcatt gcagcactat tcacaatagt 68160
aaaggcatgg aatcaaccta aatgcccatc aatggcagat tggataaaga aaatgtggta 68220
catatacacc atggaatact atgcagccat aaaaaagaat gagatgatgt cttttgtttg 68280
aacatggata gagctagagg ccattatcct tagcaaacca acacaggaac agaaaaccaa 68340
atactgcatg ttctcactta taagtaggaa ctaaatgatg agaacacatg gacacaaaga 68400
gaggaaaaac acacactaca cactacctga gggtggaaga tgggaggagg gagataatta 68460
gaaaaaataa ctgttaagtc ctaggcttag aacctgggtg acaaagtatt ctgaacaaca 68520
aaccccccga cacgagttta cctgtataac aaacctgcac atgtacccat gaacttcaaa 68580
taaaagtctg tgtgtttttt aaggcagaag tcagccccta ccttgaaaga actttctaca 68640
tagatggcta cagtgttact gagcgttttt tttttggtct atcctgaatg tcatgggaaa 68700
acttttaaac tgctctggat caagattagt gcctgtggta tttcatttct cctactcaac 68760
tgttgcagtt acatgatctt agaaattctt tttggcatat tgatgactgt tatcattcaa 68820
gttacatcaa gagagacttc tttctatgag gagctattaa gaccctcttt tggacacata 68880
cacaacttca atttacatct aagacaactt attttaatga aattgcttat ttgtttgctt 68940
tagtccttag attatatgat catttgggca gggactattc tttgaatatt tcctggcaca 69000
tttttgtctc aataaagagg aaggtgaagg aagaaagaaa ggaaaggaag aagggaggga 69060
ggaaggcatt cttgttttct atatcctaaa cctataattt tgtcaaaaaa gaatattaaa 69120
tttgcctaaa atgttaacaa aaaataggtc ataatgatgg ggccctaatt caacagggct 69180
ggtgtcccta taagaggaag aggcattgaa gtttgctctc cctgcatgca caaagagact 69240
atgtgaggac acagcaaaag gacagctgtc tacaaaccag gaagaggcct cgccagaaat 69300
cagcccttga aaaaacctgg gtcttggact ttttgcctcc acaactgtga gaaaataaat 69360
ttctgttgtt taagccaccc agcctgtggt gttttgttat ggcagcccga gcagactgat 69420
acaccagaca ttcactgtat ccaactgttt caccataata gcctttctta ttttgatcaa 69480
attactgcat caggatttga tcttaaattt catgtttcct ttgcttttgt aaatgtagct 69540
gagcatccaa atttcactca gtttggatgc taacaagatt agacagttat ctgacagtaa 69600
tcagtgcctg atcctattct gtgtcttctt ccatcaccat cccactaaag agcttgcatt 69660
ttttgtttct tttagccaga tagtaaacat ttttcaggca ttttgaattt tgccattgta 69720
aatggtgaaa gattctctct ctctctctct ctctctctct ctctctctgt gtgtgtgtgt 69780
gtgtgtgtgt gtgtgtgtgt attaggaggg ggtggtgatc gggatgctaa tctatgcaca 69840
gtgacctttg tttctatctg gctgagcaga tgtaggaatt aatcattgtc actcctggat 69900
ggtgctgctg cagctgtccc ccactgcctt tctgcccctg atagatttat tagtgtgttt 69960
tgtttgctga aaagcatgcc tcagcacaga agaactggca aattagagaa gctttatctg 70020
tgagtataat tttttggaaa catggttttt tctacacatc tgtacctata tactctgagc 70080
tctttaaaaa aaaggaggag gaagagagca aagaaagaaa aggaaaacaa acaggtaata 70140
ttgtttctgt aacatcagaa cgattatttc ccagctgaga atgttcatac tggaacagtg 70200
tcatggccat ccaccttagg attgcagaga accaattgtt ttctaacctc tgtatttctt 70260
tttgcaactg cccaccccct cacccactta actgccaact atcagccaga attttggcat 70320
actttggctc taggcacaag aaaataagtg gtctgggtta cttagtgcta aatttatttt 70380
atagtaggcg tcactacaac cttgagactg taactaacac tttctaggct ccaagcaacc 70440
ccactacgta gatatccctg cagcctcatc aaattcaacc cgtggggata ttgataccgt 70500
cctggatgga aatcagagta gccacacccc tttcaatgtt gggaatctgc caaacaattc 70560
agtataaatt tcctgggcct gggctgtgta ttttcattcc accccacccc caaatcagtc 70620
agcatgccct ggggcagaga ctaaagagcc gccagtgcct attcagagtt ggcttattcc 70680
tttctgatgg cccatcccct ccccgaaatc caagaccttg gccttagata tcttggctag 70740
cctgggcctt tctggtacca cccttcactc tctaggagct ctgagaattt tctgcacttc 70800
ccgacgctgc ttgatagagt gactcacagc ttactctttc attgactctt tctgtatttc 70860
tcttcttcag aatttctctt ctgctgctgc ttttagacat ccttgcatgt tcagtcccta 70920
aatcaccact gcttgttatt actttcatgt tcccaacatc tggcatatgg gtcttaatcc 70980
catgggtcca cccagactca tgaatttaaa ctcttctggt ctaaactctt ccaccaccat 71040
ttgagcctca attctgtgaa cagttttgtc tctaaaagcc acatacctta gtgtaagaag 71100
gcagattaat cctctgaatg tcaacttaac agttaggcct atctcccaag aaagagaaat 71160
gaaaactcct aattagtaat gactcatttt gatcaaataa tcaatttttg gaccattttc 71220
ttaaaactat attttattgc ctgtaactat ttcctggagg ataataatca tccttaaatt 71280
actatgtgtt ttgtgaagtt ggtgctttac ttttcgtgtc ctaaatatgc atatctgaat 71340
ctttaaattg tagcttctct ttcaagtgtt ctaggatttc atttgccatg gttgggatct 71400
ctttgtgatt tgataggttt cgatcacatc ctcactagcc ttctttccaa gccacagaac 71460
ggtctgtctt cattcagtag agaccctgcc attctagttt tctcgctgga atttgttttc 71520
ccatatcctt cttgagcaaa ggtgactaaa gccaaatgtt tcattctggc actttgtgag 71580
acgtgggctt taagctctca aaagaagaga aaatctcata gttttatatg agatatacaa 71640
tgaacaatag taaaatagaa atgttattgg caagaggagt ttttctccaa tatccatgag 71700
taagaattcc ttggacacat aagataacaa gaggaatata cttactctgt tttccttttg 71760
agatattctt tacataccat gaagttttcc tttctaaagt ttgcaattta atagttttta 71820
gtatattcac aagcttgggt aaccaccatc actatctaat tccagaacat ttttatcacc 71880
tgcaaacaaa accttgtacc tgttagcagt ctctcctcat ttctctcttc ctcccacacc 71940
tggaaaccac tagtctactt tctatctcta tagatttgcc tattctggac atttcatata 72000
aatggaatta ttgaacatgg ggccctttgt gtctggcttt tctcatttag cataatctta 72060
gcataatatt tataaggttt ccctgtgttg tagcataaag cgttacttca ttccttttca 72120
tggctgaaca tcccattata tggatattcc acattttgtt tatccattca tcagttgatg 72180
ctatctgttg tttccacttt gaggctctta agaataatat gctgctgtga acatttgtgt 72240
acaagttttt tcatgaacat gtttttactt atctgggtat atacctagga gtggagttcc 72300
tgggttatat ggtgactgtt taacataagt gtagaactgt ttttcaaagt gactatacta 72360
tttcacaatc ccaccaacaa tgtatgaggg ttccagtttc cctacatcat cactaacact 72420
tgttttatta tctgcctttt taattctagc catcctagtg ggtatctcat tgtggttttg 72480
agtcgtattt cccttatgac caatgatgct gagtgtcttt ttatgtactt attatccatt 72540
tgcttatctt ccctggagaa ctgtctattc aaatcctttg acatttaaaa aaattagatt 72600
gtcttggggc cgggtgcggt ggctcatgcc tgtaatccca gcactttggg aggctaaggc 72660
aggcagatca cctgaggtca ggagtttgag accagcctgg ccacatgctg aaaccccatc 72720
tctactaaaa atacaaaaat tagctgggta ttggtggcac atgcctgtaa tcccagctac 72780
tctggaggct gaggcaggag aatcacttga acccaggaga cggaggtttc agtcagccga 72840
gattgtgcca ctgcactcca gcctgggcga cagagtgagg ctctgtctca gaaaaataat 72900
aaataaataa ataaataaat attgtcttgg aaatatactt aaattaattg gcctatagtc 72960
ccagctactc aggaggctga ggtgggagga ttgcctgagc ccaggagttt gatgtttcag 73020
tgagctatga ttatgtcact gctctccagc ctgggtgaca gagtgagccc ccatctctga 73080
aaaaaaaaag gaagaaagag gaagaggaag aagaggagga ggagaaggag aagaagaaat 73140
gctcttaagt caatagttct caaacttggt tcacattaaa gtttcctaaa atcctgatgc 73200
tcaggcttta ccctaggcca gttaaatgat aatatcttgg ggtaggaccc aggcaacagt 73260
tttagaaaca aatctccagt tgattctaat gtttgagagc cattgctata gactacatga 73320
ctaagctgat gataccaata taaaaatgtt aaagatttga taatttagaa attatgccag 73380
gtattaaaaa tgggagactt aactcaaatg tgaatcataa aatgcctaat caggtcaaaa 73440
gatagagttg agatttgtaa taaagattga taaactttcc tataatagga agtttcaaac 73500
cacctatagc tagagaaaat gtctggctgt ggttcttgcc tagtgagcag gaattggttt 73560
tatgaggtaa ccatgggaga gccaataaat gtgagtgatc atgacaatta aatctttaag 73620
cccagataat ttatgtcaat tattcaatgt tcattaagga aagtgaaaaa aaatgagtat 73680
tagctaggag aaatggaaag ggaggctttt gaaaggcata aaaagattgg aggctatttt 73740
aagagacttt attggaagca tagaaaaaga gtatctgaga atttttaaaa atccaatcac 73800
ataaaaatgt gacagtcaca gtggttattg tggagggaaa atgacatctc tcaaagaatg 73860
taaaaagctc cccaagggag agcagggagc ccacagagtg tattaggtta agtacaaaat 73920
aggaaaaaag actttaagaa acactttcga agagagtcca aaacacataa agggattatt 73980
taaaatctat taaaaggaag aagctagaat aacagtggga tcttttgctg agaataaggg 74040
ggcacaggga gtgctgaggc accaaaagac aatagacaaa ctaattatgt gcctctgaat 74100
gtattgagaa agataccaga gtgatagcac attcaaattg cctactacga atggatcagt 74160
agtagttaat tcaatggttt tctgtgtttt gcatatttca agtcaggtag gcagaataaa 74220
tactgattaa tcactggaaa ctcttggtgt ttatcttgag atttctgaag gcctccagaa 74280
gaaatttttc tcgtcttgcc tctccctaaa gccactgccc ttgtcctccc tctcctatta 74340
ccaccaaggc tcctaagtgt atagtctacc ctagtcacct cactttctca tctccaattc 74400
attcttcaac ccattcttct aactccattg aaaggtcatt aaatctgact cattgccaaa 74460
gtcattaaat caacagatcg ctttttagac taaattcttt ctagccttta gatatataac 74520
accattaact gtttcttctg ttcttccttt ctgaaacctc ttttcttaac atttattata 74580
tgtgaatgtc ctggttttac ctgtctactt cttgctagct accttcactg gctccagaat 74640
tacttacgta tttctctttt ttgttttttt tttttaaggc tagtcaagtg aagcagtggg 74700
aatggagaag gaacacagaa atctgtaact ggttgtgatc aattaattgt agacactact 74760
gacttcagac aagccttacc tatttaattt tggtaacact ctgggttcca gtctcgattc 74820
acttcttaca ctatatcctt caccttgttt taacctctcc tgtgacatat cctagtgctg 74880
cctctcttcc cattttctaa cttcatggtt gatatagtca tatagatgtt tcacagttta 74940
ttctgatcca gtaaccaaaa ccagattaat atcttaccag caaacttgct cttcctttgt 75000
gtaattcctg tcgtggttaa tagcactacc atccacccgt tctcattctg gattcctttg 75060
tctccctaca catccggcta gttaccaggt tttagatatt taacctctga aatgtctttc 75120
aaatctttct attgtccatc tccattgccc aaccatagtc ttcatttgtt tttcatctgg 75180
actattgcaa tagtccccta actcatcttg ccgacatttt cagctactga tctcttgcca 75240
gcattttttt ttccccaaac acaatctagt tttaaaatac agacttctac tgcctacata 75300
actccttagg taagtattta aggtcttttg tagtctggcc ctaacataaa atatccactt 75360
ttccccttga aattaagttg tgccctggtc gtacatgaga atggccattc cttgagcaca 75420
ccatgcacat tcctcaccat gtctttgttc atgctcttcc ttgtttcaca actcttctca 75480
tttatcacct gacaaactcc tatctatcct ttaagacaaa tttctgtctc tcaaaatgtg 75540
ggccctgggc cagagcagca gtatcacctg ggaacttgtt agaatacaac ttcttggggc 75600
cccactttag actctgttta atccaaaact ttgtgtgata aggaccagca atgtgaattt 75660
taacaagctc accacatgat tctgatgcat tctaaaattt aagaaccact gttctaggga 75720
acaatttttt tatcaatggc catagcactt tacacatacc tgtattactt actgcattat 75780
ttaataacca tgtttactta ttcacttatt tatctggtct gctaagttgt gagtccccag 75840
agtcaaatac aatggtgctg tgttctgaca cctgccatag tgtctagcac ataacaagtg 75900
cttgataaga attcagcata ctaaaatata cccccttccc tccaggattc agtctagcta 75960
gagtaaatag agagggcaag atcaaatggt gtccaaggca tctactctta aaggtcgata 76020
tacaccacac aaaccaaaag cttacacact gacaataaca aatgtcagca aagtaataac 76080
caacgggtac taggcttaat acctgggtga taaaataatc tgtacagcaa actccaatga 76140
tactaattta cctatgtaac aaatatacac ttgtacccct gagcttaaaa taaaagtttt 76200
taaaaaaata aataaagcaa atgtcagcaa ggatgcagag aagctgaatc tctcatacat 76260
tgctgatgta cctactctgg aagacacttt agaagtttct tataaaatta ttccctcact 76320
gtgcgattca gcagtttcac tcctgtgtat ttaccgtaga gaagtaacta tgtatgttca 76380
cacaaaaagc tgtatgcaaa tgttttttag cagctttgtt tgtaatagtc aaaaactgga 76440
aacattaaca atcaaaaaag aaatcaagaa aacaattcca tttgtaatcg catcaaaaaa 76500
tgaaaacttg ggaaaaaatt ttacctaaaa gatgaaagac ctatacactg aaaactataa 76560
aacactgatg aaataaatga ggaaggcaca aatcaatgga aagatatccc atattcatgg 76620
attgaaaaaa tttatattgt taaaatagcc atactaccaa agcaatctac aaatgcaatg 76680
caatcttacc aaaattctga tggtgttttt cacagaaata tgaaaaaaac taaaattctt 76740
atggaaccac aaaagacccc aaatagccaa aacaatcttc accaataaga acaaagctgg 76800
aggtatcacc ctagcctatt taatttcaaa atctactata aagctatagt aatcaaaaca 76860
gcatgatgct ggcataaaaa cagacaaacc aatggaacag aatagagagc ccaaaaataa 76920
atccatccac ttacagtcag ttgatttttg acaaaagtac caagaaaaca caaaagagaa 76980
aggacagcct cttcaataaa tggtgttggg acaactatgt atccacatgc aaaagaatga 77040
aattatgcct gttaccccag cactttggaa ggccaaggtg ggccgatcac ttgaggtcaa 77100
gagtggagac cagcctggcc aacatggtga aaccctgtct ctattaaaaa tacaaaaatt 77160
agccaggtat ggtggcatgc acctgtaatc ccagctactt gggaggctga ggcaggagaa 77220
tcatttggac ccaggaggca gaggttgcag tgagctgaga tcgcaccact gcactccagc 77280
ctgggcaaca gagagagacc ctgtcttaaa aaaaaaaaaa aaaaaagaaa ttggacattg 77340
gacccttata ccatatacaa aaaatccact caaaaatgaa ttaaaagctt aaatgtatga 77400
cctgatactg taaaaactat cagaataaaa cacaggagaa aagctcctgc cattggtccg 77460
ggcaatgatt ttttggttat ggccccaaaa gcacaggcaa caaaacaaaa catagacaaa 77520
tgggattaaa ctaaaaagtt tttgcacagc aatggaaaca ataaacagag tgaagagaca 77580
acctacagaa tgggagaaaa tatttgcaaa ccatacatct ggtaaggggt aaatattcaa 77640
agactataag gaactcaaat caatagcaag aaaacaaata atccaataaa aagtggacaa 77700
aggacctgaa tagacacttc tcaaaagaaa acatacaaat gtccagcagg tatatgaaaa 77760
aattctcaca tcactgatca tcaagaaatg caaattaaaa ccatgagtta ttagctcata 77820
cctgttagaa tggctcttat gaaaaagaga gatagcaaga gttggggagg atttggagaa 77880
aagggaaccc tatacactat ttgtgaggat gtaaattagt acaactatta tggaaaacgg 77940
tatggaggtt cctcaaaaaa ttaaaaatag aactatcata taatcaagca attctacttc 78000
tgggtgtgta tctaaaggaa atgaaatcag tgtatgaaag agatacctgc actcccatgt 78060
tcactgcaac attattccca atagccaaga tatggaacca acctaagtgt tcatttacta 78120
atgaatggat aaagaaaatg tgagatatat atgtacacat acacacacac gatggagtac 78180
tatttagtct taaagaagga aatcctggca tttgcaaaaa catggatgaa cctggaagac 78240
attatgctaa gtgaaataag caagacatag aaaaacaaat actacatgat ctcacttaca 78300
tgtggaatct aaaaaagttg aactcataga agcagagagt agaatggtag ttgccacaga 78360
ctagggtgga ggtggttgac agaaatggag agatgttggt cagatcaaag agcacaaagt 78420
tccaggtagg acagataagt tgtggagagc tatacagtat agtgtctata attagtaata 78480
acgtgttgta tacttgaaga attccaagag agtatgtctt aaatgttctc accataaaaa 78540
aagataagta tgtgcagtga tggatgttga ttaaattgat ttaataattt taattatttc 78600
acaatatata caaatatcaa aataccatgt tgtataccat aaatatataa tatttgtcaa 78660
ttctgcctta ataaagctgg gagaaaaaaa ctggaaaccc aaatatcctt caacaggtga 78720
atggataaac tgtgggacat ccatacaatg gaatactatc tagcaataaa catgggacaa 78780
agtattgata gatgcaacaa cttggatgga gctcaagggc atatgctgcg tgacagatgt 78840
cagtctcaca agcttacaca ctgtaagagt ccagttctat acaacattct taaaagacaa 78900
atttatagtg atggagaatg ggttagtggt tcctaggagt taggttgggg aagcgtgtca 78960
ctataaagga tagcatgaga gagttgtgtt tataagtgtg tatgtgtgat ggaacagttc 79020
actatcctga ttatgatggt ggtttcgtgt ggtgaatttc atagaaatct atatatgtga 79080
taaatttcat aggactacac acacacacac acaaagtgca cataaaaact ggtgaaattt 79140
aaatagagcc tgtagtttat ataatagtat tgcactaatg tcaatttcct gattttgatc 79200
atgaactctg gttatgtacg atgttattgg ggaaagctgg gcgaaggata cacaggaact 79260
ctctgtactg tttttgcaac ctcttgtgag tcttaaataa tttcaaaatg aaaagctttt 79320
gagaaaaata aagcacaggg atttctgaca aaagctaaat tagaaagcac tgcttgacat 79380
aatgctaaaa caggacccag gaagtggaga gctcactgcc tggtggaggt gggaaagggg 79440
taaagggaag tggagattct tgccttgaag aacatttggt agaacgtggg ccaggcctct 79500
caaacaggtc actcctggct tggggaggag ctaatactaa ggtggaaagg gaaatgaaag 79560
cttacttctc atcagcttcc catatgggga agggggccgg aatctctcct caataggcct 79620
ccattttctc aatagggaaa acggagagaa ggggaaaagg gttcctcttt aacaatggtc 79680
acaaaaggtg atgtgtgcag tgaaagatta aatggtataa gaactcaggc tctggaatca 79740
aacccagcct caaatccagt ggcttgattt tctattgaac tttgctatac cctgtttctc 79800
tatttaaaaa caggggtaat gatactactt aactctgaaa gctgattaca ttagattgtc 79860
tatgtagagc acttagcaac cacctagcac atagataatc agtgttggct actcttttta 79920
atactattct atgccattac caattttcta agacgtaaca ataatacact cagatgattc 79980
tgaccataat gtaatttttg attaaagttt cttcaggatc cttcaatgct tccaactcat 80040
aaattatatc agccctcagt ccctatatat gtaaatacaa tttaaattaa aatagttgtt 80100
actttctatt acatgtcttt tatgtgcttt gcactttaaa tacactattt ctaaccttta 80160
tagcatgcag gataaatact attttcccca ttttcagatg aggaaactgc ttcagagtgg 80220
ttaggcaaat ctccaacatc tataaacaac acagtaaacc taggcagtct gatggcaaag 80280
cccaagctct ttccactaca ctgttacctc agtagtaatc cataaaagat gcttaaacac 80340
atacatattg tctattagtt gttcttttta catcacatta catgggcaga ctctacaact 80400
cctgccacag cctggcgcag acacttccag gccattgctg aagccagtgg agacaccaga 80460
cgatgacaga aaccaagaac ccaaagctga ttgtagcaag aattcagtct ggagttcagt 80520
cagtagataa atccgagagg catcatggaa attgtgccaa ggtccaaggt tcaagccagc 80580
agtcagaatc taaaggggca ggcaaaaccc agcaggaggc tctgcaggct ctgtgccccc 80640
cgggagattc atggcttcct ctctgtctcc tcttgttgac actgccggct ataaatgggg 80700
gctttgtgga tcctcagttg aggaggcagg tgaaaattct tggcctacca gcactactac 80760
aggacgttag aaactagggc aggaagaccc tgggtcttca ttaatcagtg tgatgaaaac 80820
aggccccagg cagttgggtc cactagtggg aagtgaaaga acactgaagg aaaccaggag 80880
tcaggacatc tggatttgct gtcccaacat ggtccctatc tggcgataaa acagcatgca 80940
aatttcttca tctaaaaatg aaggaatcag gtcagatcac tgattttcaa actgtgttcc 81000
tcagaaccca aggactccag tcctgctgtg gagagatagg tgggagcaag caaggccttc 81060
ctgtacagca cgcttccttt catctcttcc aagtactgaa ccttctaatt ctaatgattt 81120
attcagcgta acaggcattt aataagtttc tactaggctc ggggccttgt agaaggtgct 81180
gatggggaca aagctgagta aaacccagtc ccaacatcat gaattcctag attctggctt 81240
aatggggaac cattccagca gctgtcactg ttcaggattc ctctcagatt ccaagataca 81300
ccaaggcccg gagttctgcc acagaattga agataagaaa gagaggaaag aggccgagtg 81360
cagtggctca tgcctgtaat ctcaccactt tcggaggccg aggcaggcgg atcacctggg 81420
gtcaggagtt tgagaccagc ctgaccaaca tggagaaacc ctatctctac taaaaataca 81480
aaataaattg ggcatagtgg tgcacacctg taatctcagc tactcgggag actgaggcag 81540
gagaatcgct tgaacctggg aggtggaggt tgcggcgagc cgagatcgcg ccaccgcact 81600
ccagcctggg caacaagagc gaaactccgt ctcaaaaaaa aaagaggaaa gaggaatctt 81660
ccccagtatg gcaggcaatc tttcctgcct caaggagatc aatttacatg tcacctggaa 81720
gcccataata ttctgcttta gcagtgactc cttgtgattg gatgtttcct atggccaatt 81780
gtgcctgtgc ttcatgccct acttaaaatc aggacatctg ctctgccctt ttggaagagc 81840
tacaagtctc ctgccaggaa ttgctcaagg ccttttcctg cagctaaacg gagaaaggaa 81900
gttgaaatca ttgcctcata aattacaaca catgccaggg ttgtaaccta gagtctgagg 81960
ttctaggcga aaagaggatt ttgtgtgtgt gtctagtgtt ttccccacag catttaaaag 82020
ctcatctaaa atatattata attgcatgag atatggcaaa aatacattca gaaactaatt 82080
ttttgaagat aaacaaacaa agcagaatgt gcccataata ttcctaagta aagccacaca 82140
aacttccttt ccagtaaggg tatcctttgg ggctttttcc ccctccttgt caccaactta 82200
tcttgaattt atcactatgc tttttcacta ttgttcctaa acttcagctg ttatataatg 82260
agatagtggg catttagtct tatatccaaa tttccatatt tcagctttta aaatagttgc 82320
aaggatgctt ttaaagttga tcctggccag gagaggtggc tcactcctgt aatcccaact 82380
ctttgggagg ccaagatggg aggattgctt gagtccagga gtttgagacc agcctgggta 82440
acaatgagac cttgtctctg caaaaaaata aaaattaact gggtgtgatg gcatgcactt 82500
gtagtgccag ctacttggga agctgaggtg ggaggattgc ttgagcccag tagataaatg 82560
ttgcagtaag ccaagatcat gccagtacac tccagcctag attagagagt gaaactctgt 82620
ctcagaaatt aaattaaatt aaattaaaaa gttgatccta gcaaactaac accggaacag 82680
aaaacccaac accgcatgtt ctcactcata agtgggagtt gaacaatgag aacacatggt 82740
cacagagagg ggaacatcgc acaccgaggc ctgttggggg ttgggggcaa ggggagggag 82800
agcattagga caaatactta atgcatgtgg ggcttaaaac ctagatgatg ggttgatagg 82860
tgcagcaaac caccatggca catgtataac tatgtaacaa acctgcacat tctgcctatg 82920
tatcccagaa cttaaagtaa aataaaaaaa gaaagaaaaa aaaagttgat ccttaggcct 82980
gtttatagtc caagggagct gtgaatgctg aaatttgtac actgtcaatt tatatgtata 83040
ttcacatatt aatatctata gtacacatag attcaggaat gtagactttt gtcaaatggc 83100
ctagtagata ctgataaaac aacttctaat attaaattaa aattttattc tattttaaag 83160
aaaaagaaca aataagaaaa tcgtctttgc aatgaaaagg tcagaaacca aggatgtggt 83220
gtcctaatat gctgatagca gagattatat ctcctttgcc ttcctatcac tggttcttaa 83280
taccttggca agttagtatt taggaattgt tgaattaatg tttggcacat gaagatcatt 83340
aaagcaataa ctcataaagc atggggaaaa caaggtcatt tgctaaaggg gaatttgggg 83400
gcacgatatt tagcaagtct tctttcacac ttatagctaa atattttgtt tatttgatta 83460
tttgattgat ttgggtgtaa attctattgc acctctggta aaccaagtca gcctgccctt 83520
cctggttaag aaagagagac agaaatgcaa agtgtaacca gcttattaat aagccgagga 83580
tagagaaaag aaatttgtct ctgggctggg agcagtggct catgcctgta atcctagcac 83640
tttgtgaggc cgaggcaggc gggtcacttg agcccaggag tttgagatca gcctgttcaa 83700
catggtgaaa ccccatctct actaaaatta caaatattag gcaaggatgg tggcatgtgc 83760
ctgtaatccc agctacttgg ggtggctgag acacgagaat cgcttgaacc cgggaggtgg 83820
aggttgcagt gagctgagat cgcctcactg cactccagcc tggctgcact ctagcctggg 83880
caacagagtg agactttgtc taaaaaaaaa caaaaaacaa ctgtctctgg cataacttga 83940
gaagggagaa gctagaagag acctttggtt tcatcaggtc caagcactgc taaccattca 84000
gctattctgt gggcagaatg tctttgttct tccaggtgca acttcagcag ctgtgggcct 84060
gaactgacag tgcggggtaa ggatatcact ctctccatgt gaaacaaagc aggactacag 84120
gaaagcaggc tgatttggaa aggccaggcc cacccaggac aagaggcagt gctgagtgtt 84180
tggctcatga caaaacataa tttacaaatt tactggcttc aaggatgtaa aaagttataa 84240
tttactggct tcaagggtgt aaaaaggcct gcttcctagc ctagctgcaa gcagcaactc 84300
agtccatgat cagcagattt tctgaagcct gggggtggga tgcatgttgt taacctctga 84360
tgcagatgtc tgctgagagt ctgtaatctg tgtggtcatg aagatgagat ttcatccatc 84420
aattgcttga caagggctat catcgtatct ctgggcctgc gtggctctca acacacgacg 84480
taagaaacat attggacaaa agcatttcct gggagaattc tccagcaaga attcagccat 84540
tggcaaagaa tctttcaagt ggccctatct cactggagac aagtaaacat atacgcagtg 84600
catatgtgaa tatacactcc ttcaaggtgc tgcactttcc tagaaacaaa aagaatgaga 84660
ggaaaaagct ttacaggcat cctgttagga tgctttctct cgtttatttt taggctcttt 84720
tcagctctgt gctaagaggg gaggcaaagg aagggcttac ccagaatgca aagcttttta 84780
gtgagggttt ggggtgtgca aatttgttaa agtggtgaaa acccagtgtc tatggaagtt 84840
cacagcatcc acagcactca gagcccccca aatatctctg gcccttgtgt tcactaattc 84900
caaggaattc tcagccattc caggggactg tggggatccc cctgaaacca ctacaattac 84960
ccagaatgtg cccctcctaa cacataggca ttgaaccagt tcctaactct cccccaactc 85020
tcacagatct ctagtacttt aagagccata tggcacacat gcttagccct cagccttctg 85080
cctaataggg gagtgctttg ccagggaaaa ataagattag ggaagaggac aaagaaagaa 85140
gaagagaagg agtttccata tccattaatg aattcattca acagatggtt atggaacact 85200
taccattttc caaagaccgt actatggtgt gggttataga ataagaaaca gcctggcttt 85260
tgaggagtag aaactgtccg gtggaactaa cattaaaagg tggtaatata acatgacaat 85320
tgtactgatg cacatagacc ctggggtgtt ttagggacat agaggatggc accaaaccta 85380
gactgagggc atcatccaga cagatacatg ctcttgtttc tgtgagtcct gtgaggtgag 85440
tcactcacaa agaaaatgta aagaaataac tcagaataaa taaaaagata gatggcacag 85500
taagcttggc agattgatgt tggagaacgt cagttttggt ggcaacaatc tgcaaggttg 85560
tctaattttc tcctgcacca ctcggctgcc cggatgcaaa agcagacaat ggattgtggc 85620
tctgatctga gttttattgg gcagatgctg cagaagggct tgtttgaaaa gggaatagga 85680
tgttattgag agaacagttc agatgaccaa ccagggatct gaaattaggt agagacagta 85740
agagagactg ataaactatg aggaagcaaa agaaccaagt gactggaggt ctataggctg 85800
tcaatgtaca aatgtggcag gagtaagcac atgagagggc tggaggatag gatgctcact 85860
catttattcc tcagatgttt attgagtgcc ttcagtgtcc aggtagtgtt ctagttctga 85920
gagtacatca tgcacaatgc tattgggagg agaaaacaat aaataaaatc ataataataa 85980
acaagtaaat tatgtaatat gttaaaaggt aataagtact atggttggat gggggcaggg 86040
gaagagaata gagcagaata agaattcaga attccgagga tagggtataa ttttaaatag 86100
ggttgtcatc atagctctgg ttgagaaggt aacatatgaa cacacaatca ggagagaaag 86160
aggatgagct atgcagatac atgtattgaa atattccagg cagagagaac agccacttca 86220
aagcctcgca gtgtgtgagt gcctggtgtt ttcaaggaaa agcaaggagg ctgtgtggct 86280
ggagtggagt gggcctggag aagatgtaag aaatgaggtc aagaaacaac agggatcgag 86340
tgtgtaggct ttgtagactc tggtaaagac tggctttccc tctgggaaat agagagtcat 86400
tgtggggttt tgagcacaga agtgatgtga tcttatgtct ctttaatgga ttactctagc 86460
tgctatgttg aaaatagact tgagggaagt gccagggtag aagcagggag accagttagg 86520
aggctattgc aataatccaa ataagaaatg caaagtaaga ctttgatcag gtggtggcag 86580
cagaggtggt gagaaggagt tagattctgg atgtatttcg aggatagagc caacaagatt 86640
tatgacagat tggatgtggg tagtgagcaa gagtcaggat gactccaagg tttttggtcc 86700
aggcaaattg aaaggtggag ttgccattat ctgaaatggg gaagaaggtg agcaattgag 86760
agggagactt ggagttaaat tttgaacaga ttgtagtcaa attggtgttg ggatattggt 86820
gtttacaatt cctgaagggg aaccattctg agtgacccta agacccagag tgtaacctgg 86880
ggatgggtgt ctgaagagga ataaagtgaa atcattatga ttgaataatt tagaactctg 86940
gaggctgaaa agctaatgaa atctcctagg atgttctacg aggatggtgg cccaggcacg 87000
agagtaggga acggggtcag gccttatgat ggatacttta aatacaaata gttagaggtc 87060
acactaatat tagcttgagg tgtgcagaat tttaattggg tgcagattag tgtatacatt 87120
agaaataagc aagatattaa aagatcaaat ttgctgaaac acatcagata acattatgat 87180
aaaggtattt ggagttttat ttgagttaga tttacaatcc cattgtagca tggatcaaaa 87240
acagtaagtt gataaagaaa tcagataaat tttcacaatt taaattttaa ttgttttatt 87300
aaaaagcatt ttggaaagac attcatattt ggttttggat aggttaaagc tcagtgatac 87360
catttacatc aatttttata gcattttaga gagcatggtc ttgtgacatc ttaggataag 87420
ttttctgtta gtcacagcat gccaacaagt accttgtgct ccattctctg gccatgtttt 87480
cagactcagt aacttcaaat aaaataaact gccaagttga gaaattaaca tttgataaag 87540
tttttgcaac atcataccat tgagctggtg gatgtggctt aagcatctga attcattaga 87600
gactattgaa atgataatgc agaattatac aggttttgca gatgtagttc aatatttatc 87660
tatatgtatt gaaacctcac ttgaggatag aaaaatcaag caagttcttg tcttacattt 87720
ccactcaata aatgaagagg aagagataat gagaaagcta tataatcctt taaaaaaaaa 87780
attcaccttg tttctgactg acagtaaccc aattcaggct ttttactctt cataaatgga 87840
agacaagtaa cctagatagt actggctatc tataattaaa tatacaatat tgaaatctat 87900
ttgctttgtg gaaattatgt gtttgtggct gattaaaata ttcagctatg taggcttcat 87960
cttttagctc aatagaaaaa tataaatgac attggtgact gaattcctac caacgtggca 88020
aagacattcc ccagacatac ataattcacc tgctgaattg gagatgattc acctttcagt 88080
gacttcacag gtgttaactt ggccaaacaa aaaagggaaa tcatcttgta ttcatctttt 88140
gttccctgag gcaagttttc agtaagattg ctcgggaaaa atatcacaat atacatatat 88200
aagtccatag tatgtctatt tgaataatga attagcacca ctgtctgaga ggtgaaaact 88260
attcaatgta tattttctgg aaaataacta aattgagttc ctcttaacta aatcagaaag 88320
agaaggaatc ctcaatcagg atttcatgta gtactgtatc actcaaagga aaactgattg 88380
tatagtggta ctcaaataaa gtgggtccaa agaaaaatta tgagagaaac gtaccgatca 88440
gtgatctgga ccaaacagac atgtggctgt gaaatccagg cagttgcttg gtgacgaggt 88500
caccatcaga tagtcatggc ttatgtgcag gaatgtgaga atggccatgg ggaggaatgg 88560
cctgggttat gggtcttgca ggagtcccac tgcttgtgcc attgctcaaa cttctgactg 88620
ccctgtgcag ccggtgccag gtcagcagta ctctctgctc tgaatcagtg tcagcactgg 88680
tctctctaat gtagtacctt tcttcaaaaa atgctttgtg aagctgctgg ttagcactgt 88740
tcttacttct gtagttaata ttcaccacat attccccttc ttttgtggag agataaagaa 88800
attaaggaaa atcactctcc ataagtccac aatctgaaga catggaggct gaggaggcag 88860
acctgaatga ataagtggat catatgatag ggctagatct taaatttgga tacaggagac 88920
ttaaggtaaa ccacagaagc ttgttgttta tacatgtagc tcttttgcta aatataaatg 88980
tggcatgtga agattaataa atctgaatgt aatgtacaga atgtactaga acaggaaaaa 89040
attggtgttt actgagagct gaaggttaca tcaaaaatct aaaaagtaat atttttgcat 89100
catcttaaag tttgcaaaca gttttggcac atacatcatc tcatctttgc aataacctgt 89160
ggggtagata caaaagatga tgttattttc attttccaga tgaggaaata ggagcctgtt 89220
tcctggtcag acaggcttag tcagctgtga gtggcagagc tggtgttccc acctgttacc 89280
ctcaacccca gttccattgc tcctaacatg attgtatcct ggataaacat ggtatcaaga 89340
atggagaggc caagcgcggt ggctcacacc ggttatccca acactgtggg aggccgaggt 89400
gggcggatca cctgaggtca ggagttcgag accagcctgg ccaacatggt gaaaccccat 89460
ctctactaaa aatgcaaaaa ttagatgggt gtggtggtgc gtgcctgtaa acccagctac 89520
tggggagact gaggcatgag aatcacttga acctaggagg tggaggttgc agtgagccga 89580
gattgcccca ctgcactcca tcctgcacaa tagaacaaga cactgtctca aaaaaaaaaa 89640
aaaaatggag agtgaaattt gggaggctga ggcaggcaga tcacttgagg tcaggagttt 89700
gagaccagcc tggccatcat ggcaaaagcc tctctctact aaaaatacaa aaatcagcct 89760
ggcgtggtgg tgggcacctg taatcccagc tgctcggggc tgaagcagaa gaattgcttg 89820
aacctaggag gcagaggttg cagtgagcca agatcatacc actacactcc aacctgagca 89880
acagagagag actctgtctc aaaaaaaaaa aaggatggag agtgagagaa aactcagaga 89940
ctttgaaata agaagtgaaa gaggccgggc acagtggctc acacctgtaa tcccagcacc 90000
ttgggagacc gaggcaggca gatcatttga ggtcaggagt gcgagaccag cctggccaac 90060
atggtgaaac ctgtctctac taaaaacaca aaaattagct gggcatggtg gcgggcacct 90120
gtaatcccag ctactcggga ggctgaggca ggagaatcac ttgaaccagg gaggcagagg 90180
ttgtggtgag ccaagatcat gccattgcac ttcagcctgg gtgacagagc aagactctgt 90240
ctcaaaaaaa ttaaaaaaag aagaagaaat gaaagaaact tggcaattga ttgggtgttt 90300
ctgataaaga aacagaagaa ggaaaaggtg attcctaggt ttctaaaacc tggaagaggt 90360
ggacagtgag attataatat aagcagctga tgttggcaac atgcctacta tgtgccaggc 90420
catgtgccaa gcattttgcc atattgcctt attaaatcct tacaactctt tgaaggtaga 90480
tcgcataatt attattctca ttttagaaaa gggtgtgcat gaaagttgct ctcactttta 90540
gaaaaagaaa aaaatcttcc ctccaaaaca aggctaagct caactggatt cactggccta 90600
tgctgacagt acctggggcc tgggacagtg gtttggtgtt cttgtgtgta tggatgtatt 90660
acaatgtcag acacaaagta actaagccgt gctcctggcg gttatgatgc ttgcaaatcc 90720
agcactgcca aactgtttag tgcctcctag gtgctttgcc tgtggttaga acaagcttca 90780
ctaagtggat agttttgcct tggccctgcc tttaaggcag tctgccatgt catcaagaga 90840
cataggtaag aatgctctcc tccttagtta tgatttaaaa ataaaagtat aacaaagtat 90900
aattatcaaa tgactattag tagaaatgtt gcatttatat acactattta gattacaatt 90960
cttaaataca atgtctttcc ttcttgttac ttgtaattaa ttagtatcag tcactgtcca 91020
gtgtgagcct ggcattgccc ttaggttaac cagttcacat cctgaacttc tgttggtgcc 91080
cagggtattt gtctgaaacc ctgattattt acatctccct ctaactttca aatttgtctc 91140
caatctcatc taaaactatt aatacttgag aaaaggcctt tccccaattt cctgcttcta 91200
atccctttat cctctttctt tcttggaaaa gtagaggaaa atggtttaca tatcaaataa 91260
agtaaatagt atatgaaaaa aaaaaaacct ctaagggctc caaactctgt ggatatctac 91320
ctgctggtta tttattcact aagctgcaca tagcaatccc ctagcaacca taaacttcat 91380
gcataaaatc ccaactcttc tccaatacca cctgtttgta ggtagtcatc cttcttttaa 91440
aagacttggg agttatacaa ggaataagtg ccagagttta gttctttgtg aaaataaatt 91500
taaagaaatt ataagttttc acagggctgt aaagatgttt cttcccagtg gtccttcact 91560
ccaaggctgc actggagatt atgctggtga ggaagctttg gtctcgtagg tctttggccc 91620
caaggcaaaa ggtcatggct gtaagtgtct ttcttcctga tcccctctag gattgtgaag 91680
atgtccagtc ccaatctgaa cattgtgacc ttactgggca gttgtctcac ttacagtagc 91740
gcttacctct ttgggattca ggatgtttta gtggggagct caatggaaac tctcattcag 91800
gtaggtgaag ttttaaaatt tggttttgac tataaagttt tgattatttt tttaaaccag 91860
ctgctcccgt gggtggtggt ttcctttatc cttggagtgg gcacttttcg agggaatccc 91920
agaacacttg gtgaggttca ctctgtacct cgtgcgctct gtgggaccca gaccctacag 91980
atcagagtgt gtggagaact gataaaggtt cctcttgtga ctcttctgtc cccttccacc 92040
catagacaag actgtccatg ctgtgcattg ggacctccct tgtgtttggc cccattctgg 92100
gaaagagctg gcgactctac aaggtgttta cccaaagggt cccggacaag agagtggtga 92160
gtaggcagca agtacacaat gcttgactgt agatggtagc ttcagcattg gttaacagct 92220
agagaagctc atgcacatta ctgagcctag cccctttcag gacatccaaa gttcctgttt 92280
ctcattccaa accctggaat catgcagcct cataaggcct caggtctgga aggctgtgga 92340
tcagtgctgt tgaagatagg gcttcaaacg tgggctctgg ttcctatgta ccccaggccc 92400
tgtggggaca tgtgagctgg ccaatacctg gcaccagtgt gaggcagaac aagataccca 92460
gagactgttg tttggcacag gtgcgagctg gaagtgaagg gaggaagagt gattacagag 92520
aaactatagc aagtaagtag ttatttcctt ccctggagtc cagttctttt ctatgtagaa 92580
ggcagttctc tgtactgaga aggatgtgcc caaagcagtg agcaaggaag agcagataga 92640
atcaactcta agttatgtag cagccagatc accgacatgt ccctggtatc agtcatcaac 92700
ttaaccacat ttccccattt tatcaggttg tctgatgaga ctgctcaaac ctcaattcct 92760
gaccattatc ctcattgggt ataggccctg cccagaccca atatatcatt cagttggtgt 92820
ttacttctct ggaatgatgg gaatttattt tagcaaatgt tattgaatca tggtgcatac 92880
ttaccaaaag ctcagctgtg agcaaccata cctatgaaga agattgccta aaaggacaaa 92940
aactgcattc atccctcaag aacaccaatt tcttttttaa acagctttac tgaagtataa 93000
ctgacatgca gtgaactgca catatttaaa gcatatgatt tgataaattg tgacatggat 93060
atacaaccaa gaaacatggt gcataatgaa catatccctc atcttcaaaa gcttccttgc 93120
aaccctttgt tatctccctc ccctgtccaa tccttatatc ccttgttcct atcctcagaa 93180
aatcattgat ttgctgtcac tgtagatgag tttgcatttt ccagagtttt acataaatgg 93240
aaccatgcag tatggactct gttttctctg gcttatttta ctcacataat tgtttttatg 93300
aatattatag ttatttatct atgttgtgtg catcaatagt tatttctttg ttattgctga 93360
gtagtattac aatgcataga cacaatttgc ttatctgtag atggatgttt gggttatcgc 93420
cagttgtggc gattaaaatt aaagctgcta tgaacattcg tgtacaaagt ctttgtttag 93480
acataggctt ttatttctct tgggtgaaaa cctaagagta tggttggatc atatggtaag 93540
tgtatattta actttttaag taacagtcag actgtttttc gaagtggttg taccattctg 93600
catttccacc agcaatgtat gagagtccat ttcctccaca ttcttggcaa catttgattt 93660
gatcagtctt tttcatttta ggcattctaa taggtatgtg tggtagtatc tcattatgct 93720
ttcaaatttg catttctcta atgcagtatt gagcatttct tcacttgctt atttgccatc 93780
catacacctt ctttggcaaa ctttctgttc aaatcttcca cccatttttt ttttttttct 93840
gagacagagt ttcattcttt cgcccaggcc ggagtgcagt ggtgtgatct tggctcactg 93900
caacctctgc cttctgcttt ccagcaattc tcctgcctca gcctcccaag tagctgggat 93960
tacaggcacc caccagcaca cccggctaat ttttgtattt ttagtagaga tggggtttca 94020
tcatgttgac caggctggtc tcgaactcct gacctcgtga tccgcctacc ttggcctccc 94080
aaagtgctgg gattataggc atgagccacc acacccagcc tcactcattt ttaaattgga 94140
ttttttgttg tcttattatt gagttttgtg agttcttttt atattctgga tacaaaccct 94200
ttatcagatg tatgatttgc aaagattttc ttccagtttg ttcttttgtt ccttttactt 94260
tcatttactt cagaatgtct ttcaaagata agacatttct cattctgatg aagttgaatt 94320
taccaatgtg ttctttgttt ttaggtttct tgtttatttg tttgtttgtt tttgtatttt 94380
tagtagagac ggggctttac catgttggcc aggctggtct caaactcctg gcctcaagtg 94440
attcaccagc ctcagcctcc caaagttcca ggattacagg catgagccac cacacccggc 94500
cccaatgtgt tcttttatgg atcatgtttt tggtattata tttaagaaat ttttgcctaa 94560
cttaaggccc caaaaggttt tctcatgtgt ttacttccag aaattttaga gttttagctt 94620
tgacatttag gcctatgatc ggtatatggt atgatgtatt gattgaattt tagtttttta 94680
catatagaca tttgattatt ccaacatcat ttgttgaaaa gattgtcctt tcttcactga 94740
attacctttg tgcctttgtt aaatcagttg tccataagtg tgtagatcta tttctggacc 94800
ctccattctg tctcactgat gtgtctatct caacagcaat gccatattac cctgattact 94860
gtagctttat actaaatctt gaaatcaggt agtattagtt ctttgacttt cttcttctct 94920
ttcaatgctg ttttggctaa tctgggtcct ttgaatgccc atgtgaattt ttgaatcagt 94980
tcactgattt ctacaaaaat tcttttggga ttatgttgaa tctaatagat caaattatgg 95040
agaattggct tcttactaat gttgtgtcct ttgacccatg aacccattta tttaggtctt 95100
taatttttcc catcattttt ttgtactttt caatattgct ctttcacatc tttcatcaaa 95160
cttatttcta gggattttat atttttatgc tattttatat gttactattt ttttaaattt 95220
cactttccag ttgtttgttg ctaataaata gaaatataat tattattatt attttttttt 95280
gagatggagt ctcactctgt cgcttaggct ggagtgcagt ggtgcgatct cggcttaccg 95340
caacctccgc ctcccgggtt caagcaattc tcctacctca gcctcccaag tagctaggat 95400
tacaggtgcc tgctaccaca cctggttagt ttttgtattt ttagtagaga tgaggtttta 95460
ccgttttggc caggttggtc tcaaactccc aacctcagat gatctgcctt ccttggcctc 95520
ccgaagttct gggattacag gcattagcca ccatgcctgg ccacagaaat ataattaatt 95580
tttatatgct tagcttgtat actgcaacct tgctaaacta catgttagtt ctagcagctt 95640
ttttatagag tctatcagat tttctacaaa gatgatcata tcagcagtga ataaagataa 95700
tttatttcca atctcttgtc tgattgcact ggctagatac aatagtacaa tctgaataga 95760
agtggtgaga gcagatatat ttgttattct tgatcctatg gggaaaacag tcaaaactaa 95820
gaatgatatt agcagtagtt ttattgtaaa ttccatttat ccagttgggg cagtactatt 95880
ctattcttat tttgctgaga gttttaatca agaactgatg ttgggttttg tcaaaagctt 95940
tttctgggtc tattgagatg atcatacagt ttttcttttc ttagtttatt cgcatggtgg 96000
attatgttaa atggtttttt ttttaaaccc ttacacaata gactttattt tttagagtag 96060
ttttaagtta acataaaaat tgagcagaag gtacagaggt tttacatata cagtctttcc 96120
ccacacatgc atagcctctc ccattatcaa tattccccat cagagtatat acttattaca 96180
attgatggaa ctacattaat acgtcattat cacccagagt ctgtacttga cattagggtt 96240
cacttttggt gttgtacatt ttatgggtct ggacaaatgt gcaatgacat gtatctacca 96300
ttacagtatc atacagagta gttttactgc cctaaaaatc ctctatgctt ctgctcatta 96360
tctctttctc tccccatatg ttaaatgatt tagggtgtca aaccaacctt ccatccctgg 96420
gattagcttc atttggtcat gctacattat cctcttcata tattgttgga ctcagtttta 96480
taaaaacttt gtttagaatt tgtacattca tgtttttaat acatattgct ctgtggttgc 96540
cttgtaatat atttttctag ttttggtatc agggtaatgt tggctttata aaatgagttg 96600
ggaactattc ccttcttttc aatttcagga ataatttcta tagaatagca taattggcac 96660
tcatgtataa gtaccttaca atagtatgct tccttttatc cccattccta tctttgctgt 96720
tacatgttat aggccccatg caattctttt gtttaataaa tcaattatct ttaaaaatat 96780
tttatttttt tatttttaag acccaggaca acatgctgaa ttttgttatt ttctttaatg 96840
atatttaaat aatgaaaact aatcatgtat ttttctgttt agttaccatt tccagtgttc 96900
ttaatttcct gtatagatcc acatttttat ctcatattat tttcctttgc ctgaaggata 96960
tctaacattc cagtgtgggt gtgctactac tgaattcttt cagcttttga ttatctgaaa 97020
aagtctttat tttgccttca tttctgaaag atatattact gagtatagaa ttctagactg 97080
aaattttctt ttcttcttct agtactttca agatgttcct gcactgtctt ctcacttggc 97140
cttgtatctg atgagaagtg tcaggtttat tttatgtcta cacaaaatgt gtctttcttc 97200
actgcttgct ttgagtagtt tccctttatc actggttttg aacagtttga ttaggcaatt 97260
ggtttgtttt taattttaca aacaccttga atcacgtaac tggttgtgct tcttttcact 97320
ggttgtcaaa agctcagatc cacatttctt ctgctccaat tagtaaatgc tattatatat 97380
acactcttca tctgagcctt catcataatt ccctttattt tctctcttcc cggttgttaa 97440
atattttaat cctatcacag tatatatttt tctcaatttt atttttgtag tcacaaacta 97500
acacattctc ttcatcctaa gtcaaatacg gatggtccct gacataaaac agttcaactt 97560
acagtttttc tattttacaa tggtgtgaaa gcaatccaca ttcagtagaa accatactta 97620
aaatacccat acaaccactc tgtttttcac tttcagcaca gtagtcaata cattttatga 97680
gatattcaac acttcattat aaattaaatt aagctttgtt ttagatgatt ttgcccaggt 97740
gtaggctaat ataagtgttc tgagcacatt aaaggtaggc taggttaagc tgcaatgttt 97800
ggtagcctag gtgtattaaa tgcatttttg acttatgata ttttcaactt atgatgggtt 97860
tatccggaca taaccccatc ataagtcaag atcataagtc aatctgtaat tcatatgtat 97920
ataatgaaaa tgctaatgat tcttcctgca tctctgagtc ccaccctctc agttaatagt 97980
tattaacatt gtggtgtgac attcatatct atgtgcttat ataaacatat agaaataata 98040
gtttatttat tttataaaac accttgagtc ctttgtggga aaaggtagga tatgaagaag 98100
ttaaacaaat ggaaatgtgt aatgctaata atgatatcag catagaagtc attgtaaatg 98160
tttggtgtct gtttcatttt tgatagctac atttgaagct ccttgggagg gctgaccttg 98220
gagcatatag ctgagagcac atgggatact ctagcccctc tgtcatttag ccagtcaaca 98280
aggagaagtt ttgaccttga ctcttttgca gattatcaaa gacctgcagt tgctggggtt 98340
ggtggcagcc ctgttgatgg ctgatgtgat cctgctcatg acgtgggtgc tgactgatcc 98400
catccagtgc ctccagattc tcagtgtgag gggccaaatc cctagagaat ctcatcccca 98460
aactggactg acctctgtgg atacacagga gtcatccttg caacaagaag ataaaggact 98520
ccaagaggag ggagagtcag gagttgtggc ttccatgtaa ttcttgccct agtctgctgc 98580
cactcccact gctcctcctg cccgagtgtc tctttgtggg catacaatga gatatcagca 98640
tgctggaatc tgcctggcag ttctgccact tccacattat caataattaa aactttcagc 98700
tatcggcagt taccttcccc taattgtaga ggtggaggta gtagtttaag gtggcctttg 98760
gagtcagtca accctggttc aaatcccagc tctaccaagc tcaccagttg tgtgaccttg 98820
ggaaagttat gtaacctctc taagtctgtt tcctaattgg taaaattgag ataataatac 98880
tacctatctc atagggttgt ggcaaagatt aaatgaaaca atgtaggtaa aagacttaac 98940
catgtccagt acatactatt caattaacaa gaagtatggc cgggcacggt ggctcacgcc 99000
tgtaatccca gcattttggg aggctgaggc aggtagctca cttgaggtga ggagtttgag 99060
accagcctgg ccaacatgat gaaaccatgt ctctaccaaa aatacaaaaa ttagccaggc 99120
gtggtggcac atgcctgtaa tcccagctac ttgggaagct gaggcaggag aatctcttga 99180
acccaggaag cagaggttgc agtgagctga gattgcacca ctgcactcca gcctgggtga 99240
cagagtgaga ccctgccaaa aaaaaaaaaa aattattata tatctccagc ctcacgaggg 99300
gctgaggaat acagtggaat catggaatcg tgacactgca agattaatgt ttaaggattc 99360
aatgatttgc aaaaagcagg tgcataatga aatagtttat agttttgttg aggcactaat 99420
ttgattgggg tagcaaagca cataaatgag gggtaagccc tagtgtcacc aagcacacag 99480
ctgttagccc aactttatca tctcttctcc taacacgtag tcactctcat ttaggttcta 99540
gtggagtcac ctaaatgctg cagtttttac atactgaggg ggtatcatgt actctagaag 99600
aattcatgct ccagcatgtt cacaaagatc tgctttgtgt tcctggtaat tgtgggcacc 99660
tccagttctg actctgtgtc ccttctaggt gacagggaaa gacgtgtcct gcacttcgac 99720
cagcacccac ttctgtgctt cccggtattc cgatgtttgg attgctctca tttggggatg 99780
caaggttggt aaccacatct gatatggtct ctgtcaccaa gaaaatggat atgaagaggg 99840
aattacagga attaacgagg tgatgtctgc aaagaatctt gaactcagag gagacctctg 99900
ttgatgcata aacttcaaag ccatgactgt ttttactttt ctatttgtat ttgtttgggg 99960
gagaccctcc aactctttag actccctcat tcagtcctcc cccaaatcat ctggaattca 100020
cccactgttt ctcctattta ttggtctggt ttcttaattg atttgacaat accagttttc 100080
ccttcatctt ccctgcaaga ggaattatga ggagaaattt gacccagctt tatttgttct 100140
cctaagtgcc cttattatgt ctcttgtgtt ttcttcaaga tttgggcgaa ggtgtcctgg 100200
tgcctttcac ccacctgact ttctccctct ggttggaagc aagactggct ctgagacaga 100260
tggcagcatt cacagggccc tttgaggggt tccacctgtc tcacagtgtc tcccatactg 100320
ccccaaatct ctcaccatta gactcatttg tctctgttag atgggcaaaa gtagaatatt 100380
atttccagaa ggtagaggat acctgcatgg agcactgagg atggtcctca gaacaggaca 100440
gctggttttc agcttaggga gacagagaac tggtgctgag gggtacaggg cagtcctgat 100500
tccataaaca agcaagtcct gcctgacagc agactacctg ttgactatca gggcagagag 100560
ttctggttga ctgattactg gcagaggaaa aggaggagtt tttgtagaaa taagtaccct 100620
ttaagggtaa actctggccg ggcacagtgg ctcacacctg taatcccagc actttgggag 100680
gctgaggtgg gtggatcact taaggtcagg agttcgagac cagcctggcc aaacatggtg 100740
aaactctgcc tctactaaaa atatagaaat tagctgggtg tggtggtatg cacctataat 100800
cccagctact tgggaggctt gaggcaggag aatcacttga acctgggagg cagaggttac 100860
agtgagccaa gattgcgcca ctgcactcca tcctgggcaa cagagcgaga ctctatctca 100920
ataaaaaaaa aaaggggggg taaactttac ccacttcacc actaagaaag tattagaagt 100980
tgttgcttgt gaggaacagg tttaggggta ggccagacta gggcagggaa acattccttt 101040
ttaactatgt gcaaatatta ctttgacaga aatatttttt aaaagaagac tctaggaagt 101100
gaacagctct tgatctccag aatcttgcta atggttaaaa aaggagcttt agttgtgaca 101160
gatcagggtt tgaatctgac tccgcccctg gctagccaac cctgagcctc atttaacctc 101220
tctgagcctc agtttccaaa ttttaaaatg cggatgatga taatatcccc tcagaactgt 101280
tctgtctcta aagagttaat gcatgttaag agttttcagc cgctcctggt ccatagcaag 101340
agctcaataa atgttagata ttattattac tattcttcca ctgcccccta gacacttctg 101400
gaaaatacat tgcctctgtt ggttccttga gtccctgtag aagagtgtgt cctccctagc 101460
ccagaaagcc agcacttccc ccatagctac ttactttgtg actcaatttg atttattttc 101520
tccattgcct tttatatact ctcatttcca ttctatttta ctgtaatatc tttctgtagg 101580
aaaaagaagg aaaaggatgg agcatcagga aacttactga gccagacccc atagactccc 101640
tggtcagtga gaagctcctc aggaggaccc caatctccac attgagtcct aggacccctg 101700
ctctctgtca actgccccct accccacact tctcagcagt taaggccagt gatatgcaag 101760
gatcaaatat gactcactca gacaccagcc aggaatgtat agacacttga ttcacaccca 101820
tttccccttt aacaagaatt ttaatggaat taaaaacttt tagtggaatc atatctgaac 101880
atttcaaaat cacagaatta atttcatttg ccttttatta aattagcaat gatccaactc 101940
tgctgaatac cacctgatgg cgtcagttac ccaaaagttg ggcttccctg gtctcctgac 102000
ttatgtgtcc tctagtcatt gaagatctca gggtggccac atttggcctt caggccccat 102060
ttgggacact gggcattagg ggaacctgga aggtatctct tccatgctga ctccttccct 102120
tctggcacag ccagttctcc aaaatatgtt ctttagtgtc acccatgaag gtggagttga 102180
ccacgtcata tgatttgagg gtcaccagca ggtgtcctgc tgatacctga ctttattttc 102240
attattagtt ctccctctga atcccacagt cccaccccca cctcgtctcc catggcatct 102300
tcacgttctg agtcatcaac atgaacattt ttaggctggg cgcagtggct catgccggta 102360
atcccagcac tttgggaggc taaggcggtt ggatcacctg aggtcaggag tttgagacca 102420
gcctgaccaa catggtgaaa ccccatctct actaaaaata caaaattagc tcagcatggt 102480
ggcacaagcc tgtaatccca gctactcggg ggctgagaca ggagaatcgc ttgaacccgg 102540
gagacggagg ttgcagtgag cagagatcat gccattgcac ttcagcctgg gcaacaagag 102600
cgaaactcca tctcaaaaaa aaaaaaaaag aagatttttg tgcttacctt aaatctacct 102660
accagaccaa gtgttaaaag ccaggaccat gacttctttg tgtcactatt ttctgcccta 102720
cacgtactat ggcactgcac acatagtcag aaaggtgaac ctaattgaat ctatgtgtta 102780
tgtattattg actaaagctt tgatttctgt atgaatgcag ctcctgtgga gggggcagca 102840
ctttaaggtg ctatgagtta ttttctcctt agtacaaatg acaactctga gagcaggttt 102900
atattcatag gaaagagaac agaatagggc cctgggttcc ttgtagggga gcaagaaatg 102960
tcacaaaaag ggtgagaact atagatggag ctttcgctgt ctgtgcctgc cccacagtct 103020
tgcctgggtc ccagcctgcc tttgttctcc ccttttttta cccttcatct cccataaaca 103080
ctcactggca tggagccgct gctagcctgt agagatcctt tgtgtaaatt ttttgaaggc 103140
ccatcccttc tagtcagatg cagtcttgca ggtgcaaggc ttggcaagca gatggtgcct 103200
ttgggcaaat tagagaaaag agccccttcc tatgggcact accctggctg tggcacatga 103260
cttgacaagc agatcagagg tcactttcag cttccctgtg caccctcagc tttgagcagg 103320
gcaacaccag acaatggctg tggtagcact cactatcaga ggttctgtgg gcccactgtc 103380
ctccaagtgc ccaacagctc tttctgtagg gatactaacc cacccacatg atcctgtcct 103440
atgccttgtc tcagaagagt cttatttaat ggctgacttg ctgacttctg ataaactaat 103500
tctcagcaaa ggagaggaaa ataacattta ttaagtatct agtaggtata aggggctgcc 103560
ctgagggttt tcttatgtga tatcttagta aatcctcata gcagtcctta aggtaggtat 103620
tattatccta attttacaga tgaggaaatt ggttgcaaac ctactgctca ttgacctctt 103680
gttccacttc tctgagcctc cgtcacctct tcacccccca gggtctgctc ctgctgtatg 103740
gtgcctacct ggctggcctg actggccatg tcagctcccc tcctgtgaat cagtccttaa 103800
ccatcatggt gggggtcaac ctccttgtac tggctgctgg gctgcttttt gtagtcacca 103860
gatacttgca ttcctggccc aacctggtct ttggactcac atctggaggg atctttgttt 103920
gtacaactac aatcaactgc ttcatcttca ttccccaggt atggattttg cagggctggt 103980
cctcttagtc actctagagt ttttcactga caaattgctc attttgtttt ctactgatac 104040
ctttccatgc cacttattgg agagtcagaa agcagacagg ggatcctagt gagctggttg 104100
cctttgtcct ttctcactgt cctggtcagc aagggggaca aggcagagtg gtccaagcag 104160
tggtggcagc ccctgtttgc actcttccac acctgtggtg cctgtccctt gggggggctg 104220
cctcgcagtc ctgcttttcc atccaccctc tggtctgctg cactcgttcc ccatcctccc 104280
ctcatttcca tcatgttatt actatttctt tcactagcct gggagcaagg aacctttata 104340
tttttccaat tggggattgc agactcacag gaaaaaatcc atttagatgg aactttatga 104400
tttaaagtgc tttctctttc tttttattgg aggaaaatac agaacatttc tctgcttttt 104460
acaataagga gaggtagaaa ctaaataaaa atatgtttca tattatgggg attttaaaaa 104520
atcaaatgag ggaggaagac agaagcagaa atagccagat agcaaagaag aaaggtagtc 104580
agagggaaca gagaaggaat cctaggctca gaaagcaagg ggatgtggga ttgttcatgc 104640
tacaccctgg ggaccatcaa gccacatata tctaggttaa tgaacttggc actaggtact 104700
ttcttgtttc cctcctagtt ctccttttct tccctctgag acctccctca tcccactcct 104760
ccttcaagac cctgtcctga ttcccattgc aacttccagt tgactgtaaa ctaattcctc 104820
atgatggagc taactgataa tgtaagtgtt ggctgatggc acgttacagt gtatttgtga 104880
aagggaagag tgcactttgg gtcatgatgg tatgacatgg gcatagccct gttacgattc 104940
ttctctatca caaatcctca ttacagtact caacagaata cataaatatg gaaaaatctg 105000
cagcagcagc actagaaacg atggatggct attgcctctg tgccagaaac tggaggaatt 105060
tttgccaaat cttaatgccg taaaaactgg aatgaaggaa gccatttaga gctgaggctt 105120
gtttgtctgg gatgaggcag aaatgggctc tgagaagcaa ggactgtttc tccctgggag 105180
accgggggcg ggggcggggt gggtgggcag gggtaagggt aggcaggtgc cttttgggaa 105240
gcccacccct taggccctgc agccaatatt gttggattgg tagcgatcaa caatgcagag 105300
aactggtgct gaagggtaca aggcagtcct gattccataa acaagcaagc cctgcctgac 105360
agcagcctac ctgttgactg tcagggcgga gaggcctggt tgactgatta ctggcagagg 105420
aaaaggagga gtttttgtag aaataagtac cctttaaggg taaactctgg ccaggcacag 105480
tggctcacac ctgtaatccc agcacttggt gaggctgagg taggcgtatc acttgaggtt 105540
aggagttcga gaccagcctg gccaacatgg tgaaactctg tctctactaa aaatatgaaa 105600
attagctggg catggtggtg cacgcctata atcccagcta ctcgggaggc tgaggcagga 105660
aaatcacttg aacccgggag gcagaggttg cagtgagccg agattgcgcc actgccctcc 105720
agcctgggca acagagctgc taaccccttt cttccttgct tgcctgcact atagagacag 105780
caacagctag actcttcttt tgccagcttc ccatagagat aggagtgcct atatgacacc 105840
attttgaaca ctagaggttt tctgagaagc ttctgagaaa gcttttgctt tcctgaaaaa 105900
ggttataagc atggctaaca tcaccctttt taccttcttc ctgccttgaa tgtatgtgat 105960
tcctagagct atggcagctc tcttgtgaac ataaggaaaa gactaagaga atatagttat 106020
aatactagga agatacagct ctttccatgt aagattataa attctggagg aaatgatcta 106080
tgaagggaat ctgcagttca caagaagagg actacaaatg tctaaagatt tagagaagct 106140
gccttcctct ggagtagaag tgtttagaag ataccggact tgtcaataga attcaaagga 106200
tattgtctct tctcaactaa agcaaactat catgaaaaaa agctaatctt aataaaatat 106260
tgaataagga ttaaaaatat ggtattaaat ttaaaatccc aatagaagca ttgactgggc 106320
aattagacac tacaaaatat tgaattagtg aattacttta aggaaacaga aaataaggaa 106380
acaaatgaga gactagataa gaaaatatgg aaaatggcca gatgcagtac ctcatgcctg 106440
taatcccagc attttgggag gccgatgtga gcggatcacc tgaggtcagg agttcgaaac 106500
cagcctgacc aacatggtga aaccccatct ctactaaaaa tacaaaaatt agctgggcgt 106560
tgtggcatcc atctgtaatc ccagctacta gggagactga ggcaggagaa tcgcctgaac 106620
ccaggaggca gaggttgcag tgagccaaga tcacgccatt gcactccagc ctgggcaaca 106680
agagcgaaaa tctgtctcaa aaaataaaat aaaaagaaaa aaataaaata tggaaaacat 106740
ctaggaatac aattgagagc tgataggagt ctctgaaaga gaacaaaata atttggggca 106800
gaagtcatta tcaaagagct atcagaggaa aatgtttctg aacaaacaaa gccttggtca 106860
gaaaactgaa tgaattggca atctccatga tggcgccctg cttactgctc ctctctccat 106920
cctcacctct caccactgcc cccttgcatc gtaagcctca gccacatcac ttcccctttg 106980
cctggtgttt gagtcctcag cagctaggac aattgtgaca tctgggtact ctacacacaa 107040
aaatgcagaa tgaagtgctg cttgaaatct gccttccagg ttttcactaa gcaacaaaca 107100
cttgatttgt tgaattggga atggaaatgg aatgattatg aggtacagga attgggtgga 107160
tggactgcac tggccttgct ttccttctat ctcactccct ctttccctcc tagctttctt 107220
aagcttcctt tctcttactc tgtctttcct cttccatttt ctcccttgtg tttttttttt 107280
ttctcctctg gaactaactg accatgatgt gaaactaaaa aatatatttt gtagtctgtt 107340
gtattttagg tttagatggt aagtagttct ttttcaaaat ataaaagaaa ctgaggtttg 107400
ttaggtttct gtgtgtttcc ctctggctcc gaggtctttg gtagaagaac gattctccct 107460
gtgatacttg cactgtgtat tcctagaaga taatttggga aagtaatttg agtaaatttg 107520
ggaaagtggg tgaggggaac tatctgggta agggttgggg gttgcagcaa aacggggttc 107580
cttcttgcca gtgagctttc agacatgact gtgatgggag gagtttgtga aagcaaaggc 107640
acagataccc ccagggcagc gaggcagcgc cagagagcgg gtgaaatgga tgacattact 107700
aaggagacaa ggggcccaag aagccttctt tacacaggca ctcaggaaat gcctgagtgt 107760
ttatgccaag cactgaggtc atcactagaa gtcagccagc cgctgctgtt ctgacctgaa 107820
tatgacccat cccccagccc tctgctccct cagagaggca ggcaggtcct aaggtaggac 107880
attgttttct ctctcctcta accccgaaag catttcatct gctcctccct gaagatgtgc 107940
aggcctttct aatctgcctt ataattatat gtatatgtcc cagcacccct actagaccag 108000
tgagcatttt aaagaaagct tccttcattt gttcatgcat gcatccatcc atccacttat 108060
taactgctgg gtacatgcac ttaaacacag agtccgcctc taggtctagt ggggagcaaa 108120
catgaaagga attatcatac atgtgttaag agctttgaga aaggccttcc ccagcccatc 108180
tgagaactca gtggcacctt ctcagaaaat gaggctgggc atggtggctc atgcttataa 108240
tcccagcact tttcaaggct gaggcgggta gatcgcttga gcccaagagt tcgagagcaa 108300
cctggtcaac atggtgaaac ctggtctctg caaaaaatgc aaaaattggc tagacgtggt 108360
ggctcacgcc tgtaattcca gcagtttggg aggacaaggc gggcagatca cgtgaagtca 108420
ggagtttgag accagcctgg ccaacatggt aaaaccccgt ctctactaaa aatacaaaaa 108480
attagctggg tgtggtggcg ggcgcctgta atccagctac ttgggaggct gaggcaggag 108540
agttgcttaa accgggagac aagggttgca gtgagccgag attgtgccat tgcactccag 108600
ccagagacag agtgagactg tctcaaaaaa tataaagcaa aaattagcca ggcatggtgg 108660
tgcatgcctc tggtcccagc tacccaggag gctgaagtag gaggatcacc tgagcccagg 108720
aggttgaggc tgcagtgagc tgtgattgtg ccactgcact ccagacagag taagaccctg 108780
tctcaaaaaa aaaaaaaaag aaggaaggaa gggagagagg gagggaggga aggagggagg 108840
taggaaggaa ggaaggaagg aagatgaggt gttcgagctc agtcttgaag gaaacataag 108900
agttcattga agagatgggg gaaagtaggt ggcatttctg atggaataac atcatgacca 108960
gaggcaggga ggctagaaag agagtagcgt atgtttggag caccatggtc tttgttattt 109020
ttgaagcaca aatggaaacc agggggagaa tgacaggact ggggagagac acacctgggg 109080
agcttctgag gccctgctgg accctgttaa agagttgaca tttagtccca ccatattagt 109140
ttcccactgc tgctataaca aattcccaca agcttagtgg cttaaaataa tacaagttta 109200
ttatcttaaa attttggagg tcagaaatct gaaataggtc ttatttggct aaacttaagg 109260
tgtcaggaag tctgtattcc ctccagagat gcaaggggag aatctgtttc cttgtctttt 109320
tcagcttcta gaggccgtct gcattcttgt gcttattgtc ccctcctcca ccttctaagc 109380
cagccaggtt caaatctgcc agaagagatt caaatctttc tctctctcgc ccctgtttcc 109440
attgtcacat ctccttctcc aactctggct ctcctccctc cctcctataa ggattcttgt 109500
gattacattg ggcccacttg gataacccag aataatcacc cctcttgaaa tccttaatta 109560
catttgcaaa gtcccttttg ccacataagg tcacatattc acaggctcca ggaattagga 109620
tgagagagaa catctttgag aagccactgt tcagtctgcc acacccccat agcccagagg 109680
ctcagaaaac cagaatctgc ctgtccttct ggaggaaggc agaggagagg ccctgaattg 109740
tgaaattcat agctggattc cagaaaccct gaagggttga gccttaagga gtatcttcac 109800
aaatgaggaa tgaagggcta gagtaatcaa ggggtatctt ggctccactt ggccaattta 109860
gagacaggaa gaccaaaagc cctgggaggg cccttacgcc agtgctgagc tgctcctctg 109920
ccagccctgc agagaggcct cagtctggga gtgctggggg agatgaagga aaagctgtac 109980
tgcagcactg ccagggtcag tgtgaggaga ataaccctag gaggtctgat tcatccaccc 110040
aaggccacag atgaccttgt gttgttggct ccagtagctc ccaagtagga tggtgagctg 110100
agagcatcct ttcgtgggga gggggccttc aagaagggca tctgagaggg gaggtaccag 110160
gcctgaccca acacaggtca cacagactcc tggtgcgatg atggactcat gatgagtcag 110220
cagaggaccc aagaggactt gggtgataat atcaatttca gtggcattga aattgatggc 110280
aggattcaga atcctatctg agatttacaa aatttggttt acactccatg gtcggagctt 110340
aacaaatgtt tgatggatga gtaaagaaat cccaggatcc ctttgaggct acccatagac 110400
actgcagcat catttctaga atcaaggtcc cagggtcccc agtgtccatc actaggacac 110460
ttagttatgg ggattcctga gaggaaaaca gaggccttcc ccactgtggc ttcctgcgtc 110520
actcacatta ctgtcattcg gtgggtcagc agtaccccac agactcaggc agaggctcct 110580
gtttctatgt tcagcttcat tcctgttaaa ctaaaccagc ccatgcttct gcagagtgtt 110640
cctcaagacc agtttctcct gaagagcttt ccctggactg ccaccgttaa cagtctctct 110700
cttcatcaac tgagtgagga cacagacatg gcacagtgtc ctgcttacag ctgttgttct 110760
gctgctaagt ggctgtgtaa gcttagacac aacactcctg agcctttcct agtttgtcaa 110820
agaaactggg tgatgagcta gagcatcctg atgtgactag ggggcttccc tcaaaggctc 110880
tctgagcctt gattattgac ttgggttaga agttcaccca aaggaactga attttcaata 110940
gcagcaagca cattgttact gaacaaatga aaaataatta aatagctgca tgcaacgaga 111000
aagtgtcatt tgaaacttat agtgttcagg ttgcttaacc ccaggatagc tcctaactct 111060
ggctttagaa tgtggtggta gaagatactt cagctctggt tttctttgac cagtttggca 111120
atgggtaggc agatgggcta aggctgttct attttatcta cctgtcctat tcttcctttg 111180
gaaatttgtg tttgttttta gggtgttttg ggtttttgtt tttttttttt aagattgggt 111240
ctcactctgc cacccaggct agagtacagt atcacaacaa tagctcacag tagcctgaaa 111300
ctcttgagct caagtgatcc tcccacttca gcctcctgag tagctgggat tataggagtg 111360
agccattgca cccagccctt tggcatttta aaaattatat aaccttaaca ttttgtataa 111420
ttacaaaagg taaggacctt ttgtcattac catctttgag ccctccagag caaagtacat 111480
tttaaggaga gaatagcttg cgcatgtgtg tatctatgat agtgtcattc cttggtgttt 111540
atgagaaaga gtgagagagt gtgtttctgg atgtgtaatt aaataaataa catgtgttct 111600
tttatctaac agctgaagca atggaaggca tttgaagagg aaaaccaaac aatcagacgc 111660
atggccaaat atttcagcac tcccaacaaa agcttccata cccagtatgg tgaggaggag 111720
aactgccacc cgaggggaga gaaaagctcc atggagaggc tcctcacaga agtaagctct 111780
gcccctgcct ggaagattcc ctgtaaagga tccaatcatg catcggtggc ccccaaggct 111840
cttattgctg atgttctctt ttcctctcat tctcccactt ctcttaacag caagcaaaac 111900
ctcaccattt ccaccgtgac acgcatctac ttcattcatt cagtggacag atgtataatg 111960
agtcactcct atgtgccagg cattgtgcca gtgaacaatg aacaaaagca tggttcctac 112020
cctcacagag ctcacagtct agtggaagaa atagagattc attcatcaag caaacatgta 112080
attatacatt gtcataagaa ttatgaaaga aaaatcagag tggtaagaca gaataatgtg 112140
tggtaagggc aagaaaacat aacttagacc agtcagaaaa gactcattga gctgagggct 112200
gaaggttaag tacaaattag ccaggcaaag agtacaggga aaagtattcc aagctgcggg 112260
aacagcattg taaaggccct gaaatgtggt ggacactagc ttccctgtga tacattttct 112320
ctcttttttt tttttttttt tttttttgag atgaggcctc actctgtttc ccaggctgga 112380
gtgcactggt accatcttgg ctcactgaaa cctccacctc ctaggttcaa gcaattctcc 112440
tgcctcagcc tcccaagtag ctgggactac aggcacccac caccatgctc agctaacttt 112500
tgtattttta gtagagacgg ggtttcacca tgttacccag gttagtctca aactcctgac 112560
ctcaagtgat ctacctgccc tggcctccca gggtgctggg atcacaggtg tgagccgccg 112620
cgcctggcct cattttctct ttttacatag agtagtgtct tcatgtccaa gatctcctgg 112680
ggtccttact gtctttccca ggtactggct acagatctca atcagcccat catcccagaa 112740
agtccaggca tgtctacaga tggagaaggg gactaaacaa gggcttctga atgtgattgt 112800
agcaccaagg gagaatgagg cagctccccc gggcttcttt cttctgtatt tgagccagag 112860
ttggcccctc tcccagactt gggcagtgtg atgcaggcat gaagaaagca cgtggaaagg 112920
tttgaaggct tcgttgactc aggaagaagg cacagggccc aggggagtta gtcagtattt 112980
tgacactaac tgaattacat tccatatttt ttcagtttag aacctatctc aggaggtgtt 113040
atttggaaaa ctgggctttt tttttaggac tgctgcctag gtattaatag tccctgatga 113100
gaggatagtg tggtggggac ctagaaaaca caacagatga agggactcag cacacccagg 113160
cacccaccgt tcatgcccct ctatggttct ggaccatttt tgtccatcag agtaacacct 113220
ctccatttct ttactattaa gtatttcaaa gccagatttc tttccacctg gcaagggagt 113280
aatattgcct ttgatactct gtgaagtctt caaataagca tttttttttc ctggctacac 113340
agaaggccag aaacttggct agaacagcca ggatagtttt cattcacagt cagctgatgc 113400
tggaacagcc aagtggactg actctttagc cttatggtaa tttgcaacgt gctgtttgta 113460
cttctgccat gctaccctgt ttcccacgca gggactcaat ctgctatatc caaaaagatg 113520
ctttgagtct gcagaggaag cccttcaatg ggcacaggtg cacaagtggt aagaagctgg 113580
cctccccagt gcacgctaca cctggaatct ctttcccaga acaggccaga gaacaagcgg 113640
ccagtcctag ggcccggtgg caggtgtcag gaggttccag catctgcatc cccagctcca 113700
gcattgcccg ttagagaaac atgagtatct ctcctggctc aacatatgta cagaccttga 113760
ctctggccca tggtgtgcag tgccttcctg tgcaggcccc actcccccac tcaggccttc 113820
ctcttacttt cccgtgatct gggcagcccc atcttctcac acttttccct cttgcctcta 113880
tagccagggg tccccccaga agctgtttcg gacagcatct atcacatcta tcactgactt 113940
ccctgtctaa gagaaggcca gcagacagaa ccttccacaa ggctgaagtg ctttcctcat 114000
acactctgca gccaagtaaa caaacctatt acttttgtta cctgaaccat agaaacaaga 114060
ggctaattcc atgtctcctt atggcctgcc ccctgtgaaa catgcaggtg gatgttttgc 114120
ttccctcaat atgccaaaaa taataattaa taagctcatt gaagtgcagc tgccgtggta 114180
ggtcagattt cagtctcata atggcagtgc ctcacaccac acctctaatt agtatgcagc 114240
catggtaaaa acagagtccc acttcttttt ctggaagaag gaaattttct gtttaggttg 114300
atgtttctaa atctgtcacc agccagcttc ttcccaactc catgtttata gtatctttct 114360
atactcaaag gagtttatag ataaggcaca aaaagacagc actcagattt cacccacggg 114420
agtagttgcc atctgccgat gggtccttcc taactctgtg aggctataga ggcctccaga 114480
agcccacatg agaatgtgca cgatgggctt caggaggaga ggctggtgga ggagggagtt 114540
gaggtccccc catgagatcc tcagagagat gcctggcaca gcccaggatc acaaacacct 114600
gagtgtttcc ctattgctca tccattctgc ccctgacaag tccttgagtc atctgcactc 114660
acccagcaac acccagacct caccactctg cgggcagagg gaagggaggg aggacaggca 114720
cacatgtgct cagctgaaag tctcttctac cttactcacc agtccctcac tggccctgga 114780
ctctcttctg atggtaaaag aagtatactc aaccagggtg aaactagcaa taccaactat 114840
cagaaaaatc accttcccaa ttctacaagg ggagcagtgc atctgcttgg agagttgcta 114900
gtcagaatat tggactattt tgcttaagct actgctccct taaaggatca tttctaggca 114960
actctcccat gtaaacctga gatgaaacca caggttcact ctataactag tagtcctagt 115020
tagctgttat ggacggtata actaggcaat ttgtattggt tatcctaaca cagggaacat 115080
ccttttgttt ctagggcata ataaatggag gtccaaatgc tcatgcccag ctcctaaaga 115140
tgatagtaac aaagaggtag cattttggtg ttcagacaag cactttctag aacatttgct 115200
tacattattg ccttcccaga accctcgacc ccatgtcatc tgccccaagt ccagacgttc 115260
cctgtgaata tctcctccct gctctgcctt tgaggatcag aagtttccag agatggacac 115320
acagtctgaa ctagagaatc agctgctgca ccacagaaag atgtctgggc tgcagtcgtt 115380
ccctgcaacc cactgccaac actcctactc ctacttcatg ccccacaatc tcgcagttag 115440
gacaggcaca cctctgcagc tctcacctgc cagccctctc cggcacaact tgtttaccag 115500
ctaacatcca gcgagtaggc aggtcagtag cagaactgcc ccaggctcct tcgtctcctg 115560
ggctccattc tagggctgct gaatcaagct agcaggggct taagcccaac agtcctttca 115620
tttctttgtg cttcttcaat agttctgatg cttgcactcc tttaggtgag tggttcccaa 115680
catttttggc accagggacc acttccgtgg aagacagttt ttccacagat agtggtgggg 115740
ggatggtttc gggatgaaac tgttccacct cagatcatca gacattagct tctcataagg 115800
agtgtgcagc ctagacccct cacatgtgca gttcacaata gggtttgcgc ttctgtgaga 115860
atctaatgtc tcagctgatc tgatggaagc tcaggtggta atgcttcctc acccaccgct 115920
cacctcctgc tgtgcggcct ggttcctaac agtccatgga ctagtactgg tccgtggccc 115980
aggagttggg gacccctgct ttaggtgaaa tcaacagctg atattgccac atggtagctt 116040
tggccactca ctcccagagg tccagcctag ggaggtgata acaccaacct gagattctct 116100
ttggcccctc tcagctccaa tcttatttga ttgtcacaga aatctccacc cttctccttg 116160
ttcttcccat tttctaggct gtttagtaag aggcaaaata cttgttctcc tacttcttca 116220
tcccctggag atatgcttca catttatcta aatttttgca aaagtgtgat aaactccaag 116280
tgggaccatt ccaaacatta ttcagctcat acctgcggag tggcctgacc ctctcagttc 116340
tgggaaaggt gagagggcgc tgcagtggcc agcaggcact cagactgggc ctccttgctc 116400
ttcataagca atgccgcaca gtgtggggat gtaaggagaa gaccaagata atgacaataa 116460
atcatggttg gcctttattg agcaccgttt atgtcagtta ttgtgctagc actttacatg 116520
catcaactca tttcactgga gggaggcacc tccttagaac ctgaggtcac cagccaatac 116580
actggaagaa ctgagatttc agccaaggtt ctttgaaagc cacaccttct ccaccatggt 116640
gggcactatg gaaccctcgg cggcatcttt tgttgatggt tttgctttta ttttacagaa 116700
aaatgctgtg attgaaagcc tgcaggaaca agtaaacaac gccaaagaga agattgtgag 116760
gctgatgtca gctgagtgca cctatgacct cccagagggg gctgccccac ctgcctcttc 116820
cccgaacaag gacgtccagg cggtagcctc ggtccacacc ctggcagctg ctcaggggcc 116880
ttcgggtcac ctctctgact ttcagaatga tcctggcatg gctgcccggg attcccagtg 116940
cacttcaggg ccctcctcat atgcacaaag ccttgagggg cctgggaagg actccagctt 117000
ctccccaggg aaggaggaga agatatctga ctcaaaagac ttttctgatc atttagactc 117060
aggttgtagc cagaagccat ggactgagca aagcctgggt ccagaaagag gagaccaagt 117120
ccccatgaac cccagccaga gtctcctacc aganagaggc ggctcagatc cccagagaca 117180
gaggcatctg gagaactcag aggatccccc agagcggcgg tcacgggtta gttcagtaat 117240
cagggagaaa cttcaggagg tcttacaaga tctgggcctg ggccctgagg cttccctctc 117300
caccgccccc tcttgtcatc agcaaacctg gaagaacagt gctgccttca gcccccaaaa 117360
gatgcccctc tccaaggagc tcggctttag cccttacatg gtgaggagaa ggcgggcagc 117420
tcagcgggcc cgctcacact ttcctggctc tgcaccctca tctgtggggc atcgggcaaa 117480
caggactgtt cctggggcac acagcaggct acatgtgcag aatggggaca gccccagcct 117540
ggccccacaa actactgatt ccagagtacg aagaccttct tccaggaagc cttcactacc 117600
ttcagatcct caagacagac caggtaccct ggagggcagc aaacaaagcc agacagagcc 117660
cgagggggct agagggagca aagcagcctt tcttcgccag ccttctggtt ctggccgggc 117720
cccaagtcct gctgccccat gcctctccaa agcctcacct gacttgcctg aacagtggca 117780
gctgtggccc ccagtgccct caggctgtgc ctccctgtct tctcaacaca gctattttga 117840
tactgagtcc agcagctcag atgagttctt ctgccgctgc caccggccct actgtgaaat 117900
ctgcttccag agctcttctg actctagtga cagtggcaca tcagacactg accctgagcc 117960
tactgggggg ctggcttcct gggaaaagct gtgggcccgc tccaagccta ttgtgaactt 118020
caaagatgac ttgaaaccca cgctggtgtg aaaagcaaca gagctggtct agacacagag 118080
gtcagtccaa gagaagctgt accaaggccc acaggagaag agccaatttc tggtctttgg 118140
ggaacagatt agtgccctgc atttgaccag cccataccat gtttcagcta ggctcactgt 118200
gttactttga gtacttcttg atctataaaa agagaggcat tgcctgtcct gttactacct 118260
cgcagcctta ctataaaaga ctccagttga gtgactatga aagacactga ctccttggat 118320
aaaaggtgct gaatgaacac ataggatttt ctgtccaggt cagcctacat tctgtaaaac 118380
tcttaatata ttcagatgga tggctgaatg gacagacaga tggagagatg catgggaaat 118440
ttctgtagaa cttgaggtgt ggactgtgac ccatcaaact ggccttttgg tggacagacc 118500
taccaggaag ataagtctcc tacatccttg ggcctcccac tcctggaagg cagtggtttt 118560
atttctgctg aatgttgtga acagcacctc cctagattcc agcttctggc cagacccagc 118620
tcagagccac ccctacacca ctatttcttg atggtgtctt tccaccatta tggcacttta 118680
ccctcctctc tgagacagat ctccatgcgc ccgcaggctt cccagatctc tcccctggga 118740
tcggatgtac ctgaggtcct gactgtcccc actgtcccct tgtcctgtgg ctcatcctcg 118800
attcacccac tgatgcagtt ttgtactgcg gggaggcaca caccagcaat ttctgttggg 118860
gtatgggaga acctgttggt caagagtgct tttggttcca ttggggttac atgactacca 118920
acagacacat aaacctggaa gccaaatgga gaaataaaaa ggaagacacg agggacacga 118980
aaacaggaaa gaaaacagga tttgaatatt tcacttgagt ccagcatagt acttggcaat 119040
atcatatttt tgtgattcct tttgataacc ctgtgaagta gacactttca tttttacaga 119100
caaggattat gaggcttaga gaaatgaggt agtttcccgc aacatcacac tgctggacag 119160
agatgtacac acagctcctg ggactcaagt aggtgggttt tcccagggac acatggcttc 119220
atgtgttctt ctgggaatgg caggtgacgc ttggcagacg agacaacaaa gcaaggctca 119280
tgtaagaaag ctgggatgtg ctcccctata gtccagaata atagacctgg gtcctcacct 119340
caggaaacgg gcctccactt cctcactgcc aaaggccaca ctggcacctc ccaagggagc 119400
tggggagctg gtgaaggatg agtgcgagga actcagccac caccagagcc acagggagag 119460
cacacctggg tccactgtgc ttattgctga gctggctgtc atgtccaggc tgtcccctgc 119520
cccgagtcct gtgtatacat ctgtgggtgt gcacatgttt gcatgaagga attcaggcct 119580
tattaaatat tctcagaggg gggcatttgg ctctaaatgt atcatcaatt tatcatggaa 119640
tcttgggggc tgctgacacc cctggactct ccaggcactg aaccatgagg ccctcctgga 119700
agcacagctt cttctatcat ctacttttaa acaggaattt cctaatttat tctgtgcatg 119760
ggtttgcagt ttcttgtgct gtgtgtgtgc tgtccaagtg gtaccataat aaaagagaaa 119820
tgactcccga gaggagtctt ttcagaaact gtaatctggg gctggccagg aggggcccgg 119880
agaaggctga cccacccaaa gaaggggaac cagagaagcc atcagagctg ctgccgggct 119940
accctgggtc ccagtgtacc ttctaccaaa gttccatttg aacagattct tctgtgttct 120000
ccctaagaag cctcttatcc cagaaacact ccctcaatgg acataggaaa ccctggagac 120060
cctggactct tcctgcccct gggggtcctg tggctgggct ccccctcctg cagctccctt 120120
cctcccagca tgccaccact agcagcccac cattcattca tgtggactct aaatctggca 120180
atccttctag ccttctcact ctgtctgctt ctagaacctt agtcccacca tccccgccct 120240
tctacatctc catccttctg tttagaattt tttttcccac tttgtgccct tgtgaattat 120300
tcatccttca aggctcaggt ggagcataca ttctttcttc aacctttccc agccatcccc 120360
aaagaaagct gattgattcc ctagttaaat aaggaaggat gggctggaag cagtggctca 120420
cgtctgtaat cccagcac 120438
<210> 12
<211> 120438
<212> DNA
<213> Homo sapien
<220>
<223> E529D GPR156 isomer GAC genomic DNA
<220>
<221> variation
<222> (117154) .. (117154)
<223> n is a, g, t, or c
<400> 12
ggggaccgtg ggcgtcctgc acatagcagc gggcttggcg cttctcggcg gtccgacgct 60
gatgaggtga gcacagcgac cttaaggatc cacaaaactt caaacactta attattaagt 120
gaaagtggaa agggggaggg gctttctctc cctttccaga atctgggcag tttgtttgga 180
accggtaaag aaactctcat aggaacttga ggtgagcagg ggtcacgcat cagggatgcg 240
agtggcaatt tcagtggaag agacgggaga gtactgtaat ttggtgtgaa gatggggccg 300
tgggttttct gctgaataag cgaccggctg tgctgaaaat gagagatccc gaaacagttt 360
cccaccgcct gtagactttc cagagtctcc tcacgccgaa tctgctttgc agggcatgtt 420
cacccccagg gtgtagagtg gcgggcacga tgggctcccc catggagatt gcaaagtcct 480
gaaaagggac aattgtattg cactgcgtct gttgaactgc cttgcttctg ggcatgaggg 540
agtcacctgg aagctgcaac atccttgtac cctggcaagc agccctttcc aagttagctc 600
tgtcagaaac tagaggcctc taggtagaac tcaaggtatc catgtactcg tgaagaatac 660
aaaccttgag gtttttaaaa tcgaattttg ttaagatttc aggatagaaa tctgggaaga 720
gaagtcatgg catggcataa cttacccctt tgttagtttt ctaggtacat gcatgcttga 780
attagaggta aatgatgccc tagcctatca taaaatgtct ttcctggtgt agttctttaa 840
accagaatat ggaggataac attacatttt tgcatcctag ataaaaggga aagattttca 900
gatggggctt acacagcggg agaaattgtt gatatagttg tattaggcag caaggcctgc 960
aaagaaaaac ttctttttct ccaccagtgg ctgaattctg cacagaatgt ctcctcgcag 1020
tctgggtagc agcccggctt gcaaaaacag tgcttctttc attgctgcag gtggggcaaa 1080
tgcgcttgcg gataaatggc tggggaagcg tttgcttaca ggttaaggca atttgagtct 1140
ggagaataaa gtgctttagc aggctgtgct tgagttaggt gtcccttgtg aggaatagag 1200
gtggctttct ggtccccatt ttgccagcct aattcccctt cagggacact actgtctctg 1260
gaatgttccc tctgtttccc cttctcttcc acccccagct tttagcttct ccccattccc 1320
cagtaaagtc tagaattgag cctggtcaga gtcaaagttc tgatagccta gggatataga 1380
acttcaagcc tggtgaaggc agaaatgaga cctaggagag acccaagatg ggtgagatga 1440
aacaactttc agcctagaag gctctcaaaa gagtggaaaa ataatgattg agggaaacag 1500
attctctgga aaggagaata ggtgcttaag tgtttgtttt cagctgaggg ttttaatatt 1560
tccatttttg ttgtttaacc ataagggaat ttccattata gggtaggagg aggatgaggc 1620
cttctctgaa aactgcatcc ttctccttga atttgcattt tattccattc ttatgtaggt 1680
ttcagagatt aattggggga agggggagag aggaaagaag ccagaggctc tgacatgctg 1740
cagaaacagt gcaacgtgga ctgacttggg ctgcaaaggt ggatttgggg gttgaaagaa 1800
atgttctaca tttagttgaa aaaaaaaaat cagagccttt attttgcaaa ggtcttgaga 1860
atcagaacat tcatgtttag ttgctgatga attttgcctg ataaaggatg caaatcacta 1920
tctcaccttt ttttctccag tactttatta tgaaaaattt tagacataca gagatgtttt 1980
ctacctctca ttttataaac ttattatctt aaaacaaact tgttaataaa aatcagtgtt 2040
tagaatccag acatatgtga tctggtcctg gacagagctt gaatcagaag gtgtttcaaa 2100
tatagatgtg tgaaggatat taacatttta agaaaaaaat atggatctta ttcttctgac 2160
tttcccataa gaatcttgag cagacccctt aactgccttc tttttcccat tcttaaaatg 2220
tcagtcagtt ggatgatatt actctcctgc ttaacaccct ccaatggctt cccctcacac 2280
tgtgaataac attcaactct ccaccagggc ttgtgatttg gtctggtgcc ctcatattct 2340
atggccgtcc tcttgcttac catcgtcctt gctcttccct ctgcctgaac actcttcctt 2400
cagacactgc cactgcttct tttctcagct cattccagtt tcttttcata ctctccagaa 2460
tgatggccac ctgatctaaa acagcctgtg gtcactccct gtcttctgac cctgctttat 2520
ccttcttcat ggcacttagc actccctgac actatatagt atatgtgttt ccttgttaat 2580
tgggcatgtt ccccactcta atgtaaactc catcaagaca aggaattttt ttgtcttatt 2640
tatggctgtg ttcctatttg gtatattatg agcaattaat aaataactgt tggattaatt 2700
aggtaactaa attacacaaa taaggcattg actcccataa gggtggcaga acccttggta 2760
aaatactaga agtcctttga ggtaattcat aattcaagtt aatcaatatt tgataggtaa 2820
atgatgaccc tggagatcag tggcctcttt tatcctcaca gcacttctca gctgaatcct 2880
atgctaatag ctggccagtt ttgacaaacc cacatcccaa acaagacata aaatatttca 2940
gtcacagaac ttttcctcac gtctctttct agtcacctcc accccacaga agcagcaaac 3000
cttgttctga tttctaatat catagattag tgttgctggt tcctgaattt catataactg 3060
cagttacaca gtatgcactc ttgtgtttgg cttctttttg ccctacacaa tgtctgtgat 3120
attcatctgt gccattgtgt gtatcagtag ttcatttctt ttttttccaa ggtagtattt 3180
attgtatgaa tattgaccat gtgtttatct gttctcttgt tgatagatac ttggttgttg 3240
ccagtttgtg gcaattttga acaaagctgc tgtgaaccta taaagggtct gcctcatctt 3300
gagtcttctc tactttatat gaaaatcttc cttgtgccac caatgcagag agaagtatgg 3360
caaggttatg ggggctgtga ctgatgtagc agcttgcatg taccccagcc agtgctctct 3420
ctagacagct ctgctgggag ctgacctgct tcccacttta gagggaaagc acttggaaaa 3480
tgagtgtcta acaaattagc gagccctcca gtgcactctt aagtgcttta aatccttgaa 3540
agagacactg tggaatgcct gctgccatca ctgttgtatt tccctcctcc tctcagcttc 3600
cccatcccag cacaagttga ctctaatcag cttctgagca ttatgctact gaggggttta 3660
aacattcatg agcaagagtc ttgttcagag cctgataaaa tattcatgtg tttccatggg 3720
gcattggttt ccatctagac ttctcaaggc atttttctga gatgcatgtc gtaattgtga 3780
agaactcaga cagtgatgga tgatacggcc ctgtgttatt aaaccctacc acacagagca 3840
ccttgctttc tagggatgga gaagaatgag cacacagaaa aattgacatt aatcctgtct 3900
agatcaagag aaaggctaca tgtactgata aaaatggctt gagtaaagag gggcctgtta 3960
atatagtacc aacaaaggta tgaatccata gaggagagtg aaaagaactt gttaaaatga 4020
gaggaatgct gggatgcagt cattccaagt ggaagaatgg gggaatcagc attgtaaaat 4080
gcacagttcc tttgacactc atgtggacga ggttcatatg agacaactgt gctgagtgct 4140
gtaattatca caacctgcta tgagaggatg agagtagaag tggaggctag gcagggtttc 4200
caagtagagc cagagagcta ttccaagagg agtcaacatt tctcttcaag gaagaagtgg 4260
ctttgagtca ggttctgaag gaggtgtgcc tctttgactg gcagctgcgg tgtggaaggg 4320
actttccaga gagacagaat agcatgatag agtgagggcc aaagtgccgg tgtggtgtga 4380
gtaaggagag aaggtgggtg gatgggggtc agggcagggt tgcagcaaga cataaagcag 4440
gagagctaaa ggccagctta tgaaggccac aggaggatgg acttcagtct gtttgctgga 4500
gggccgtgta acttttggcc agagattggg ttacattttg aggagttctt gggaagtata 4560
tccaccctag gcaaggcctt gaggtatgtt tatgtccaag gcatttccag aatattctgc 4620
tgtgtccaga acactatgaa gactctacgt ggtctactct aagagaggta aaccagagga 4680
ggtcagatat actcagtata ctcctgggac tgaccagaaa caggcctcac caggcacctc 4740
tctgccccca gcacacaaac actcagaata ttctgagtca gattgaatcc acagcattcc 4800
ctagacttct tcatgaccac tttgcctcag ctgggggagt tgcaatgatc taagtatccc 4860
cttatcacct gaatctgggc caggatacct cagacatggg ttgccaggca actgagggct 4920
aagtgatgca gctggccaat catccccaca aagcccaggt ctgctttgac caggccatcg 4980
ggctgtgacc agagaggcaa cttggggggt tgaggtcatg cagactgatg acttgtggac 5040
acaactgcca ggccccttcc atatgtcttc ttcctttggg ttgcagattt ctattcaaaa 5100
atgcctcagg atgttgattt tttaacccat aataaaaata gtgaagtagg gaggagtgtt 5160
aaacatgtca gtcatctata ccttatgttg tcattgggaa gaaataactg tggaaacaat 5220
tgtcccggga aagtcagtct tcagtcttgc agtgaggagc tttgcatatg tggagattag 5280
ctagaaagct ctggagttct gatggtgaga agggatttct tgggtcaagg ataggaaagg 5340
gcaagggagg accttcatga ttctccccag ggctttgctg gttggaattg ctcttctgct 5400
gccatgggta gcatggggtt tcagtgactg aaaacaccca ggaaagtatg ctctgggtct 5460
tcatgttgcc atctgcctac actggaatgt cagaccatca gtcagcactg ccagctctcc 5520
atcttgattt tctaagagtt attgagaaaa ccttgaaagg gaaggcagaa gtgggtgtct 5580
taactaggga aatgccaagg tcctaaaggt gtggtctagg ttgaaggtgt ggtaagggcc 5640
tgaagtcatt ggtctggcag tacttcagac caataaagtc tttcttggct cttatctaaa 5700
atattcctga ttttctgtgt gaggtggaat ctctcaagtg ctgcattaat cagtcttttg 5760
gctgaacagg taaatagggt gcatgcttaa ttgagtgcct tttctttttt taaagtttca 5820
gcttttattt tacattaaga ggatacatgt gtaggattgt tcatgggtaa attggaccca 5880
ggcataagca cagtacccaa taggtagttt ttcaacccat gccccctccc tcccttcccc 5940
ctgtagtagt ctgcagtatc tatctttcct gcgtttatgt ccatgtgtgc tcagtgttta 6000
gctcccactt ataagtgaga acatgtggta ttttgttttc tgttcctgca ttaattcact 6060
taggataggc ctccaactgc atccacgttg ctgcaaagga catgatttca ttatttttta 6120
tcctatggtg tttatgtagc acattttctt catccagtac actgttgatg agtgcctagg 6180
ttgattccac atctttgcta ttgtgaatag tgctgtgatg cacatatgca agcatgtgta 6240
tttatggtgg aatgatttat atttctttga atatataccc agtaatggga ttgctgggtc 6300
aaaggtagct ctgtatttaa gttttttgag aaatctccaa actgctttcc acagtggttg 6360
tactaattta cattcccacc aacaatgtat aaatgttccc ttttcttcac agccttgcca 6420
gcatctgttg ttttttgact ttttaataat agctattctt actggtgtga gatggtatct 6480
tattgtggtt ttatttgcat ttctctgatg attagtgatg ctgagcatgt tttcatgtct 6540
attggccaca cttgtatgcc ttcttttaag aagtgtcttt tcatgtcttc tgcccacttt 6600
ttaatggagt tatttgattt ttgcctgttg atttaagttt cttatatatt ctggatatta 6660
gacctttgtc agatgcatag tttgtgaata ttttctccca tgctgtaggt tgtttactct 6720
tttgatggtt tctcttgctg tgcagaagat ctttagttta attaggtccc acttgtcaat 6780
ttttgttttt gttgcagttc tttctgggga cttggccata aattctttgc caaggccaat 6840
gttgataagg gtatttccta ggttttcttc tatgattttt atagtttgag gtcttatgtt 6900
aaatctttaa tccattttta gttagttttt gtatatggtg aaaggtaagg gtctagtttc 6960
attcttctgc atatggctac cagttatccc agcaccattt attgaatagg gagtcctttc 7020
tccattgctt gttttttgtc agccatgttg aagatcagat ggttgtaagc gtgcagcctt 7080
atttctgaat tttctattat gttccattag tctatgtgtc tctttttgta ccagtaccac 7140
cctgttttgg ctactctagc aaattctttg gaattaagga aaatagggac acaatttatg 7200
aagacctctg ggatgtagcc aaagcaatgt taagaggaaa gtttatagcc gtaaatgcct 7260
tcatcaagaa gctggaaaga tctcacatta acaatgtaac tttgcattta aaggaactat 7320
gaaaaaagga caaaccaacc ccaactctag cagaagaaaa gaaataacta aaattaaaga 7380
aaaacttaat gaaattgaga tgcaacaatc catatgaaag atcagtgaaa ccaagaatag 7440
gctatttgaa aaaataaata agattgatag actgctagct aggttaacaa agcgggagga 7500
gacagtgaga gagagagaga ggatccaaat aagtacaata gaaataacaa agatgacatt 7560
acaactgatc ctatagaaat acaaaagatc cttggagaaa actatgaaca gctctatgca 7620
cacaaattag aaaatctaga agaaatcaat caattcctgg aaacaatctc ttgagattga 7680
atcggagaga ttgaagtcct gaatagacca acatcaaact ctgaaattgc atcagtaaaa 7740
caaacaaaca aacaaaaaaa acccttccaa ccataaaaag ccctggacca gatagattca 7800
cagccacatt ctatgagaca tgcaaagaag aactagtacc aatcctacta aaacttacag 7860
aaaatagagg agcagggact cctccccaat tcatcccatg aagccagcat cagcctaata 7920
cccaaatctg gcagagatat gatgaagaga tatgattttt gtgtctatgt tcagaccaat 7980
atccctgatg aacatagaca caaaaatcct caacaaaata ctagcaaacc aaatttagca 8040
gaacatcaaa aagttaattc accatgatca agcaggcatt attcctggga tgcatggttg 8100
gttcaacata cacaaatcat agtgagtcac catgtaaaca gaattaaaag caaaaaccgt 8160
tatgatcatc tgtgtcatct caatagacac agaaaaagct tttgataaaa tctaacatct 8220
cttcatgata aaaactctca acaaactagg catcgaagga acatacctca aaataataag 8280
ggccatccct gataaaccta cagctaacat catactgaat gggcaaaagc tggaaccatt 8340
ccccttgaga actggaacaa ggcaagaatg cccactctca ccactgctat tcaaggtagt 8400
gctagaagtc ccagccagca cagtctggca atagaaagaa ataaaaggca tccaaataag 8460
aaaagaagaa gatgaactat ctccctttgc tgacgatata attctatact tagaacaccc 8520
caaagactgt tccaaaaggt tactagaatt gaaaaatgat tttagcaagg tttcaggata 8580
caaaatcaat gtacgaaaat cagtagcatt tctaaacacc aataacgtcc aggctgagag 8640
tcaaatcaag aacatgatcc catttacgac agctgcaaag aaaaggaaat acctaggaat 8700
atagcaaacc aaaaaggtga aagagctctg caaggagaac tacaatacac tgctgaaaaa 8760
aagttagaaa caacacaaat aaatgaaaaa atatcccatg ctcatggatt agaaggatca 8820
atatcattaa aatggtcata ctgcccaaag caatgtatac attcaatgct attcctatca 8880
aactactaac atcagtcttt acagaattag aaaaaactat tctaaaactc atatggaacc 8940
caaaaagagc ctgaatagcc aaagcaagcc tgagcaaaaa aaaaaaaaca aagccggagc 9000
atcacactac ctgagtgcct tttctgaaca gatatttcaa tgattctgtg attattcatg 9060
agccagtgat ggctgcctgc ttttggatgc tgctaggata aatgcagaag atcagagtga 9120
agagggagag ggaagcataa cagcagcaga gaggaaaagg gaagagagta gtgacgtgct 9180
gaaatcgcag agattgtggg tacccagtta tctacaagtg agaaacaggg ataaaagaag 9240
atcaaataac tacccatggg aattttacat gcaaatattg ctgacttcca aggcagctgt 9300
gaggagaaag gaagggagga gacacaaagg cagctgtcac agtcaatccg aggaatatta 9360
ataaaaactt gacacatgaa aacacatggc cgtatcacaa cagcctgggt cccagcaagg 9420
atgtctattc aaacccctct ttcacatttc cttatattca ttcacagtat taggtatttt 9480
gcaagacatt catttgcact tgcaaagata cacaaatgca gagtacttaa aagggtaaac 9540
tatcctaaaa tattagtggt gagattataa atgattattt gtattttttc aacttatcta 9600
tgttttccat gattgtttta agaagtgtga atttctttga taatcagaaa aacattaagg 9660
agaaaggggg ttaagtaggg aggtagagaa agaggcatgg ggtggggaga gaggattgta 9720
gaaaagaaaa atatgttgga agatgaatga acaattttaa aactttatgt ttcacagact 9780
gctagcttgt gcatattttt ctttattatt gaatatatat gtttatcacc ctcagaagat 9840
ctggaagtac caattggcat gaaactgaat tgcaaatact gagctaagta tcacacctcc 9900
aagaccattg ccttggccag tgccattctg tgtgtgacat gtggcttcca gtgatgctca 9960
aagtattttc cgccaaaggc taatagagaa cacttcaaac ctgggcagca gcatctctcc 10020
cacagggttt aatatttata cttgtagcca cgtggctggc tttgtgcttc tcatctctga 10080
agtatggaac aggagccaac aaaggctgtc aatagttgga gtagtgggat tttccaagac 10140
aaaagcgtga gttattctcg tccacgtgtt tgctggctgc tcactggctc aggcagcccc 10200
ttggcaagct ctgtggctga ggctttaaat aaatagatgt agtttttgtt tcacaaccac 10260
tgaccttttc tggaggcact gttgattctg ggctttaatt ggcttctgtt gagtgacaca 10320
aggtgaaccc tctcttcaag agcagaagct cctatctgct gttaaccacc agcatcaatt 10380
caaagcaaat gccagaggac cacatacctc actgaactct ggggactggg gttacttgta 10440
gttatgtctc aataaatact ttttatattt taacttttgc atttttaagt tgtaaaagct 10500
atacacactc atggtaacaa gtctagtaag acagcagtat ataaagaaaa tatggccagg 10560
cgcagtggct caccccatag ttccaatact ttgggaggcc gagatgggtg gatcacttga 10620
ggtcaggagt tcaagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatta 10680
ggctgggtgc ggtggctcac tcctgtaatc ccatcacttt gggaggctga ggcgggtgga 10740
tcacaaggtc aggagttcaa gaccagcctg gccaagatgg tgaaaccctg cctctactaa 10800
aaatacaaaa attagctgag cgcagtggca ggcacctgta atcccagcta cttgggaggc 10860
tgaggccgga gaatcacttg aacccggggg gcagaggttc cagtgagccg agatcctgcc 10920
actgcactcc agcctgggcg acagcatgag actccgtctc aaaaaaaaaa aaaaaaaaaa 10980
attggccagg taaggtggct catgcctgta atcctggcac tttgggaggc cgaggtgggt 11040
ggatcacctg aggtcaggag ttcgagacca gcctgaccaa caaggtgaaa tcccatctct 11100
accaaaaata caaaaattag ctggacgtgg tggcaggcgc ctgtagtccc agctactcgg 11160
gaggctgaga caggagaatt gcttgaacca gggaggcaga ggttgcagtg agccgagatc 11220
gcaccactgc actacaacct gagcgatgga gcgagactct gtctcaaaaa aaaaaattag 11280
tcaagtgtgg tggcgtgtgc ctgtaatccc agttacttga gagggtgagg cgggagaata 11340
gctcgaaata gcttgaaccc aggaggcaga ggttgcagtg agccaagatt gtgccactgc 11400
actccagctt gggctaccga gggagactcc atctcaaaga aaaaaaaaaa gaaagaaaat 11460
ataagtaatc tccaccttct ctcactccca tctttctgac aaaaccacta tttaaagcgc 11520
ccaggctggg cgtgcgggct gacatctgta atctgagcac tttaggaggc agaggcagga 11580
ggatagcttg ggtccaggag ttcaaaacag cctggacaac atagtgaaac tccgtctcta 11640
tgaaaaaaaa aaaaaaatag ccaagtgggt ggtatgtcat cctagctact tgagaggatg 11700
aagtgggagg atcgcttgaa cccaggaggt tgaggctgca gtgagctgtg atcatgacat 11760
tgcactccag cttgagtaac agagtgagac cctgtctcaa aaaaaaagtt tcatgtgtat 11820
tcacatgtca cgatcacagc tcactgcagc ctcaacatct ccagctcaag ggatccttcc 11880
acctcagcct gccaaataac tgggaccaca ggcacatgcc accacacccg tctaattttt 11940
aaacattttt gtagaaacga ggtctcactg tgttgcccag gctgatcttg aattcctcgg 12000
ctcaagtgat cctcccacct cagcctccca aagtgctggg attataggca tgagccactg 12060
cactcagccc cttcactcct tttctatgtt caaacaaaca tatgagtgtg tagacttatt 12120
ttctattgta tgtgaaaatg gaatcatata tgttattatt tctttcattt tatttagtac 12180
atattatgta cattattcta gattaacaca tataattgat ccaatttatt atttttaata 12240
gctacctaat attccattat aggaggttcc ataatttctt cccattcatt acttccccat 12300
tgatagatat tcatgttttt cttccaactt tttttgcaca acaacttatg ctacaataaa 12360
cattctacat ttattcctat actttgggtt ttatttccat aggagagatt cccaaaattg 12420
tcatttttgg gtcaaaggga atacacaatt ttaattctca ctgtaggtct cctttacagc 12480
agttgtttct ctcctccttt tgtctttctc tcccctctcc caccacattt tgccagcagg 12540
gcctgtgtgt ttaagaagga aagcctgcag tgagaactcc tctgtgccaa gtgtggatta 12600
tatcagctta gtggggaact ggagtctgca gtgtctcagt tacattgtgt ctctcttgct 12660
tttggttggc cagactgttc acaattcccc ttgctgattt attccatgct gtggaattat 12720
acatggtctt catccgtggc aggatcatct gaggggtggc tttttgggaa gggtgtcttt 12780
tcagaaagaa taggctcagt tactgtactt tctcacaaag ctatatctgt tatgtttttt 12840
tgttatgccc tttctttaat agttggattg aaaaaggttc ttcaattccc atcccggtct 12900
tctgtcttca ttttgaggac ttgggattta gggagtttta tgagtatata atcaatcaac 12960
tgtaactgat tatttgacat gaggataatt agttaagaag gtaggggtct tggagcttaa 13020
ggatcagtgc caagcaacag acgtgaacat ttttaaacaa atggttttaa caaacccggt 13080
attaggagca agcttcccag gagtactaag ctttcatttt ttaattttgc ccttgctggg 13140
atgtaaaact tcagtctagt ctaccagaat agagaggagc tggattctcc accacaccag 13200
ggctggagag gagaaaatgt cagagaagcg ttaagggaag ctggtaagta caaataagtg 13260
aaataaatat aaacagtgaa ctgacaaaat ggcaaaaagt gaatgaaatt tgaaaatcct 13320
cagctgaaga ttattgtgta accagtggtc ctgtgagcta gtggacactt tataaaaatc 13380
tgtgatctct aaaacatatt agatacccca gtgtgaatct gtgttcagaa tacaaccatt 13440
agctaagcaa gacagagaaa tgataagtcc tgttggcaga tattttgcta ttgacttcta 13500
taacatatgc tgcaattttt actcagcagc tttggaatgg atttctatgt cctaggttga 13560
aaactaaact aaaagaaaaa cagaatagaa gttactgcac ttaatttcta aggagaaaat 13620
tttaacttta gtttgtgcat gtatatgcct gcaaaataag cattaccctt tatgttaata 13680
caaacttcac atgaatgttt aattttcaaa tatgcactga ccagtaataa tgatggcaaa 13740
attagactct atagtaggtt tatgttttat aacttaggga ttctataatg tatcttagtt 13800
gatgtcgtag ttaatagtaa ggatagtaat atcttataca gtttgcactg tcgtctgagt 13860
aaagattatc tttaaacatt tgttcctgtc agaaaaattt taaggctaaa cctattataa 13920
gatattaagc atctgatttt ggctataatg gactatctgt gagtagattt ttactcctat 13980
acaggacatc tagaaaagct gagttttaaa aatctatttg aaggcataga agacctaata 14040
aggcagctag gacttgagag ctaagacctc agaaagaaga gaaactcatt gagtgttcca 14100
aattctaggc tactttttcc ctgtagacac ttaccatttt taagtagcac atgaggagaa 14160
cccaaacaat aagcagctgc taaaatcaga gaagccaggc agattattcc acagtctgat 14220
agggctgggg aggaaaaaaa aaaattgaat tcaaggaaac caaatgattc aggacatgag 14280
aaaccatgat catggacaga aaagaggccc agaaaaatca actcaatagt ctaagcaatt 14340
ttccttccaa gtcattcact gatttataag tagcgcagac caagaggttg caaaaatcca 14400
aacacaaaga aggtgctaaa aagctgagaa gctaatcaga gctacttgca atcttattac 14460
actaggaaga taaaaattat tatagaatgt aaagcccacc aatgtggtat ggcctgaaaa 14520
acaccctaag ctttcagttg ggactgctga cggattatgc ctgaccagtt aaaggaaacc 14580
agaaatagac ccggtcaaat aaaatattga agtccatttc ccgatcaact tagtcactga 14640
ttagattaaa gtaatctgtt cttattttaa caccctagca taagtcttct ccatattctt 14700
tggagaagaa aaaatgatcc agaacctgtg tatttttcat atgtggtttc tggtattcag 14760
caaagcaaaa caaaacaaaa acaggcatac caagatatag tttccagaat atggtacaga 14820
gagaacccag acttcctgag ttgagaagac agagctcccc atgtctgggg agaccagggc 14880
aactagagtt tgtaggacag agtattggag aggagagagc tgcagagaga accccagagt 14940
tcctcacagg gtacacctca agtataaagc tgagtactga gcagcacatg catgtaagga 15000
aactacctgg gataaagaaa gaactaccca aaaggattag aagaaatagt gctcattgtt 15060
cacacagggc tgggaattgt gcctattccc accagctaga cttgaaaagc tcataattca 15120
tggagggttg ggtagtatac tttgaaagac catgccttag tagtgggaag tagccctaga 15180
ttgagcactg cactgatcct gtctaacaaa tcttttaaaa agacccaaaa ggaacaaatt 15240
gttccagtta atttgactgc atcccagaac aaagctcaaa actatttaga ggtatttgga 15300
atagcagtat tagtaatatt gcagagggaa gaatattgcc agggataaag aaaatcattt 15360
cataatgata aaggagttga ttcatcagaa agacataaca gtactaaaca tttatgcatc 15420
taataacaga acttcaaaat acataaatga gaaattgata gtgttccaag gaggaataga 15480
caaatccata actgtagtcc aaagtttcat taaccttctc tcagtaattg atgaaataac 15540
agaaaataat taggtatata aaagaagata aaaatacaat caactagctt gacctcattg 15600
atctttataa gatactctac ccagctacag caaatacata ttcctctcaa gtgtacatgg 15660
aacatttatc cagttagacc atattctgaa ccataaaaca agtctcaata aatttaaaag 15720
gattttagtt atataaggtg tgttcttgat cacaatggaa ttaattaaga aatcagtaac 15780
aaaattctca aatatttggt aactaaataa catccttcag aataactcat tagtcaaagg 15840
agaaatcaaa aggaaaatta gggccgagtg gagtgactca catttgtatt cctaacactt 15900
tgggaagttg aggcaggagg attgcttgag gccaggagtt gaagatcagc ctgggcaaca 15960
gagtgagagc ctgtctttaa aaaaaataga aaaaaaaaat tagctgggca tggtggtgtg 16020
cactcataat cccagctact tagctggagg attgctttag cctaagagtt tgaggttgca 16080
gtgagctatg atcatgccac tgcattccag cctgggcagc agagtgagac cctgtctcta 16140
aaaaaattat ttttaataaa aaataaaggg aaatgagaaa atatttgggg ctgaaagtaa 16200
aagctcatat atcaaaagca gtacttaggt ggaattttat agtattataa gcttataagg 16260
tggggcacag tggctcacgc tggtaatgcc aacactgtag gaagtcgaga caggcggatt 16320
gcttgaaatc aggagttcgg gaccagcttt gacaacatgg caaaaccctg tttctataaa 16380
aaatacagaa aattagctgg gtatggtggc acgtgcctgt agtcccagct acttgatggg 16440
ggctgaagca ggaggatcac ttgagcccag gatttcgagg ctgcagtgag ccgagatcac 16500
accactgcac tccactccag cctgggtaac aaagtgagac cctgtccccc cacacccccg 16560
caaaaaaaag cttataagaa gaaaggtctc agattagtgt cctcagcttt catcttaaga 16620
aaccaaaaca gaaaaagagc aaatgaaatt caaaataagc agaagaaaga aaataagaaa 16680
tatcaaagca gaaatcaata aactagattt tgaaaagtag agaaaatcaa tgaaagcaaa 16740
tgctgtttca ttgagaatat taataaaatt gattaacctc ttgacagaaa acaggaggag 16800
gaaaaagaga ggagttacaa tttaccaata tcggaatgag agaggtgaca tcactacaaa 16860
ttctacagat actaatggat aataaggaaa cattatagct tttctccaat aattccatca 16920
acttattaat agatgaaatg aacaaattcc ttgaaagaca caagctacca aagttcactg 16980
aagaggtagt agagaatgta aaagcccaga tctattatag acagtctcga aagttagaaa 17040
tagaagagaa cttccctagc ctgataaagg gaatctatgc aaaacgtgca cctaacatca 17100
tatttagtgg taaagcaaat agtaatataa tcgatttttt ttcttttttg agacagagtc 17160
ttgctctttc acccaggctg gagtgcaggg gcgcgatctt ggcccactgc aacctccacc 17220
tcccgggtcc aggcgatctt cctgcctcag cctcctcagt agctgggatt acaggcacat 17280
gccaccacac cctgctaatt tttgtatttt tagtagagac agggtttcac catgttggtc 17340
aggctggtct tgaactcctg acctcgtgat ccacccacct tggcctccca aagtgctggg 17400
attacaggcg taagccactg cgcccagctt tttttttttt tttttttttt tttgagatgg 17460
agtcttgctc tgtcgcccaa gctagagtgc tgtggcgtga tcttggctca ctgcaacctc 17520
caactcctgg ttcaagtaat tctcctgcct cagcctcctg agtagctggg attacaggtg 17580
cccaccacca tgcccagcta atttttttat ttttagtaga gaatgggttt caccatgttg 17640
gaccaggctg gtctcgaact cctggcctca ggtgatccgc ccaccttggg atcaccaagt 17700
gttgggatta caggcgtgag ccactgtgcc tggcctgcct agacttttaa cttatttgtg 17760
taattacttc aagtatagat tactccaatt taaacacaaa gattgtgaaa ctagatgaag 17820
aataaacata ttcaaaatga ttattaaatg ttttaattgg tgacagagtt tttcatagcc 17880
ttttatcatc tcagtgcatc atgttttatt tgtaggtagc cacagagaaa cagctacatt 17940
tataagaaca ccatgaagaa taattaaaat gttctttttt tttttttgag acagagtctt 18000
gctttgtcac ccaggctaga gtgcagtggc aagatcttgg ctcactgcaa cctctacctc 18060
ctgggttcaa gtgattctcc tgcctcagcc tccctagtag ctgagattgc aggtgtggac 18120
cactacacct ggctaatttt ttgtattttt agtagagatg gggtttcacc atgttggcca 18180
ggcttgtctt gaactcctga cctcaggtcg atccacctgc cttggcctcc caaagtgttg 18240
ggattacagg tgtgagtgac cacacctggc ctaaaacatt cttttatccc tgacttcagc 18300
tgagtttagt ttgaaatgag gctctttatt tggggtgatt gggctttgca ggagggttgg 18360
tgggtggcct ataattcccc ccaatattgt atgtaagata ttacatgttt gtatacagtt 18420
tttcaggaga gagtccgtag ctttcatcag tctctcatga ccaaaaacta tttaagaatc 18480
atggcttgaa gaatgaaaga atcgagtgcc atgttaagtg tctaatttct caataatact 18540
tccctgaaac taatttctag agaataattc aaatgacttg atctaaatat gtgtgcatga 18600
gtcatcaaag cagcctggag taacatatta aaagttatcc caagggtctg tctggttcaa 18660
actctgatga aagccctata tttcttatcc tggactgggt ttctcatagt atgattccca 18720
gatcagcagc agcatcagca tcacctagga acttgttaga aatacaaatt ctcaggccgg 18780
ccccaggcca tacctactga gttacaaatt ggagatggga ccaggaatcg gtgttttcta 18840
aggagctttc caggtgattc tggtgtgcac taaagtttga taaccactgg gttaggctat 18900
aattagaaaa tcctgttctc cgccccgctc ccaagccagg tttagaacag tttgttaagc 18960
aagtatctgc agaaagacca gtctaatgtt gacagcttct attttccatc tttatggaaa 19020
aatcgtaaag cctcaaaagc ccaaatcacc ctcacacaag tgtcttgggt tgcacagcaa 19080
caccaaacaa cagtttagag taatccaatg tccagctgaa attggaatta tagagacaca 19140
gcatgtgagt tcactcacaa aaatttttac caggaggctt tttagggatg agccccgtaa 19200
ttccaagggc cttggctctc agcctccttt gaggcatata acacagtctc ttgaacagac 19260
tgaccctcag taatgaggtt tcattaccct cttccagaca tgtggcaccc tcacaaacat 19320
cctttaacag agtgctcagt atcaccatgc ttcgtttgca aagtaactta atgaattcgc 19380
tcagcctata ttcttagtac ccagtggtag ggatctcagc tgtagcagca taaaacttga 19440
actgtccaaa accagtctct gaaaccttca agtgtttatt ctgtctactc ctgctgttgc 19500
ttgaagcttg atttgttgtt acaccttact gttttgctga tgagaaatag cacagggtac 19560
ttctcagtgg ttctcattaa aggagggcag ccaagtggaa ttcattcttg gctcttaata 19620
gttttcaaat gagaatttta ttgcatacta atgagcacta attgacattt gtgactgttt 19680
tttatggaaa taatgcatgt acaatttgca taatagtacc taagtgcttt taggtaacag 19740
tacaactctg ggaagttggt gaaggttttt gtatgatgct ttttaaaaaa gttcccaaac 19800
cccagcccct agaatagtat agaatattaa caggtctctg ggatccaaat ataaggcagt 19860
agtagtgact cagttcctgt agttgtacca gcttgtacct gagagtcaga aaatgcatca 19920
gggcaggtct ctaaaagcag gaagcgctcc cacagtagcc agggaggatg ttccagccct 19980
ctctaccttc atgtgtcaac cctcctgctt ctcctaagtc atgagtatct agacagtgct 20040
gaggattgtt ccaaggactc ctacactgta aaatgttttc taaacatcac ttggttgata 20100
tcaacaaaca tggattgatc acctactatg tgccaggcac tgtgctagat gccagagtaa 20160
gcccatgttg gcttgctgcc tgctgcatcc ctatctctta gcacaatgag gcaacagtta 20220
tccatcaatg tttattgaat taatgaacat gctgtctgcc ctcagggatc tgaggattca 20280
ttattcttac aaaatctgac gttgaataca gtataaaatt tgttgctctt catgttagaa 20340
atattaatta ttcagaactt ggaattctgt taggaaattt agagaaacaa gataatcttg 20400
gttttatgtg ccccaagttt tctgtatatc aaatgaccct tttaaatttt gtgaaaatga 20460
aagaagccaa tgtttactga agatctagta cgtatcagtt acttttgcac acatcctata 20520
catcctatga tttaagcatc aacaaaacct atgaggtgta gatagtatta tctgtgttta 20580
attgagcaag cagctaagaa ctggagaagt gactaaccta aggcatcaca gatagaaaat 20640
tgtggaactg ggacttaaat tcagcctagg ctgtgtctgt tgcactgccg cttattacat 20700
taaatgatcc taggatatgt taagcaaagc caaactctga agtattgtac tagtgatacg 20760
gctccgatga ctggaggaac actggggttc ttggtctcat gccggtttgg ataaaatgac 20820
atggacacac gtggagtggt tttagggagg gaaaagttta ataggcagga aagcaggaag 20880
gaagaagaaa acagctcccc ggtacgggga gagaagtagg gggattcaaa caaagagaaa 20940
acctcatgtg cggcagaaaa gtggctgctt atatgaggat gcaggaggag gtggtgtctg 21000
atttgcatag ggctcagggg attggtttga ccagtcatgt cattcctgca gcctgtgaaa 21060
aaactgaccc tcccacccta gctttttaat atgcaaatgc agggcgccat tatgttttac 21120
acacatgggg acatgtgggg gtggccatgt tgccaggcac atgtaggggc aagggcaaga 21180
agatggcagg aatcaccatg tttggatgga cccagtttct aatggctggc atttgcatat 21240
caaagcttgc tggcccagct cagagccggg gctttcctgc tagacaagaa acgtttctgg 21300
agctgcttta aaagaaataa aaactcccca aggacccctt ttcctctcta tctgcctaaa 21360
ataatttatt aataactcct gtaacactag gatggaggga tgaattggtc caggggtctt 21420
ggtgtgtgcc ctgcattcag ttgacctact gtttacaata cacctactgt ttacaacact 21480
attttctaga tcttgtgggg aacccaaacc aagggccagt ctggctcacc tataattcca 21540
ccaagcagcc agaaaagtat aaacgctcta cagcaaaggg ataaatcaag gtttagtaga 21600
agaaaagctt tataagtaat gtggaactaa aaggttgaat atagttttca ataatgttga 21660
gcataaatgt tctccagatt gtggaaagat cactaactgt tggctgggaa gggtaggaga 21720
ggagagagtt tgaaacacag agaataggaa ggagtggtga tgtagtccaa taactcaccc 21780
agaacccatg gacgtgaaag ctttgtttgc tctcagatcc ataactagac taaaggagtg 21840
aatcagatct gctcccctgc accccaccct gctcaccttc cacacctgcc aagggccacc 21900
cagcaattcc attctgcttg tcaaatcccc taaggaggat atgtctggaa cagccaccac 21960
tcctccccct gctcttccct ctggtatgtc aggattccct gcacaaccgt gctccagggt 22020
ccttgggatg attattcaga aaccagagaa gtatgtagaa aacttaatcg gaggcactta 22080
aaggctttaa aagggaattt taaaaaccat ctttccctct tttataaggc agtctgagta 22140
tttaagaagc aaattaattg agtccacttt acagtgttgg ggcaaaagca tgcaagttcc 22200
aacatttaca cactaacaga aaattctttt cccttccact gtgctccttt tctttcttgg 22260
gcctgctcca caaacttcta accacagtcc taaattggta ccccatgacc ctgtgtgctt 22320
cgattgccta cactggtttc agacccacgc tgtggattca aatcaaacct gcctttctcc 22380
ctgttactat gtccacccag caccctcctt gcacacacag tctttctctt ctttcctcca 22440
tgtgcagacc tttaccacag ctgtcccaaa tgtgtgaaag gccaaccata actcttcctt 22500
taaaggtcct ttagagcagt atggaaagag tgctgaactt ggaagaccta gattctcttt 22560
ctatactcat tatgtgatcc tgagcccctc acttaacctt gcagggcact tacaaaataa 22620
agagatggag ttcatgatat cttaaggtca ttttccatgt ccaacattct ctgactcttc 22680
atctttccct gactcaacat tctgttccta tatagtcaac accttcccac cttaatctca 22740
tgctcatgcc ctcttagaaa gtctttacaa ctgttgaggg tgcagtggct catgcctgta 22800
atcccagtac tttgggaggc cagagtgggc agattgcttg agctcaggag tttgggacca 22860
gcctgcataa catggtgaaa ccccgtcttt attaaaaata caaaaaaaaa aaaaaaaaag 22920
ccagatgtgg tggtgcttgc ctgtggtccc agctactcag gaggctgaaa tgggaggatc 22980
acttgaaccc aggaggcaga ggttgcagtg agctgagatc atgtcattgc attccagcct 23040
gggtgacaga gagacaccct gtctcaattt aaaaagaaaa aaaagaaaga aagcggcggg 23100
ccgcggtggc ttacacctgc aatcccagca ctttgggagg ccgaggcagg tggatcatct 23160
gaggtcaggg gttcgagacc agcctggcca gcattaagaa actctgtctc tattaaaaat 23220
acaaaaatta gctgggcatg gtggtgggca cctataattc cagctactca ggaggctgag 23280
gaaggagaat cgcttgaacc cgggaggtgg aggttgcagt gagttgagat cgtactattg 23340
cactccagcc tgggcaagaa gagtgaaact ccatctcaaa aaaaaaaaaa aaaaagaaaa 23400
tatttgcatc tgtgaactgt cttctgtgtt gaggatgttt gtggcagaag gagatagacg 23460
taggctctgt ctacgtctgc ctggtgcctc cacaaggagc agtgtatgct cagagaatag 23520
aagtgaattt tactattagt ataggtgacc catattgaaa atgtttgtaa atctgctacc 23580
agaacaacac agtcattcaa agacaattaa aaatgcattt tatacttcct gctatttata 23640
attattcatg gatctgctgc ctacagtcag gtagtaaaag gagagccaga aggaatcata 23700
gtgaacatct catacaatgc tatctttgtt gttggtttga acataagcat ttttgcgtga 23760
atttgcgtgt aggtctcttt tatttctctt attgcataac ctgaggctga aatacttcaa 23820
gtaatgtatc tatttgctca tattgggtag aaacatccct attattccaa ttttcccttc 23880
tcctgcttaa aacatatagt gaaatgaaag atgcagagat aaggaaatca gggaaaagaa 23940
aaatagtcat aggatactaa aatgagccac agatacctga aactgcatag ttgctataaa 24000
tgagccataa atttgattct gagctttcca gtggccccaa aaagataaac ataatagtat 24060
ttattccatg acataaaaat gtatttgtat ttctctgtgt tcaagaggaa gagaaatttg 24120
tactatgggt cctcatgaag gagccactaa gtcagtgttg tagaccacac attcaacgat 24180
atcgtattaa tacccatgat gatgaattca ttcattcaat aagcatttat tgagtactta 24240
ctttgtgctg tatatgtttc agtgtattgc agtaattatt ctttttgatg ctcaaattgt 24300
cctattgtgg gtcagtagga gcccgttgat tcatgtcctt ttgacattat tctgtagttt 24360
ttgatacttt ttttcctagc atgatgagat gttccaggct tatgtcgtat atttcttgtt 24420
ccgtaactca aattgaccat tttgttaatg aaacttgatt tttttcagtg aaaagtggtt 24480
ttatagaaca caatctgggc acttgaagtg tttattgtta ctgggttgtc attacttaca 24540
agactcagtt aacaaattag gaaaaagatt gatttagaaa gaaaataaat cctgagttca 24600
tattgttatt tccaatttaa agattaaagg gttttcgtat aacttatttt atatgtgtat 24660
gtcttttctc ttactttgaa atcttggttt ccaataacat gaacataatt acttccttta 24720
tcctaatagg tacgtatatg tgtatatgtc tatgtatgta tgtatgtagg tatgtatgtg 24780
tgtatgtttc tatctgtaaa acaggaaaaa tacccaccta atggagctta agatttcttt 24840
atgagtattt tttgtcctta gggtatttaa tcaaattact gttacttaaa ataatgtttc 24900
tctatgtggt tatgccatca acttcatata caattatttt atttcaattt gtcttcgatt 24960
tttaaggatg gttttcttct tctgatttaa ttttgttttt aaattatgta aaatattttc 25020
ttggtttcag agtcaaatct atgaacattg agaggtctat tttgcctctc tgtcccctcc 25080
cccttattat tttactcccc ttatagataa tgcttttatt tttccattac tttttttttt 25140
tttttttgga gacaggagtc tcgttctgtc acccaggcag gagtacggta gtgtgatctc 25200
ggctcactgt aacctccacc tcccaggttc aagcaattat cctgcctcag cctcctaagt 25260
agctgggact acagacactg accaccatgc ctggctaatt tttgtatttt tagtagagac 25320
agggtttcac tgtgttgatc aggctggtct caaactcctg acctcaagtg atccgcctgc 25380
cttggcctcc caaagtgccg ggattacagg tgtgagccac cgtgcccagc ctctattact 25440
ttttgaaaat aagccaatga cctatatgta tcctatctcc tttcttacac aaaaggtagc 25500
aggccagagt tcaagattac agtgagctgt catcatgcca ctgcacttta gcctgggcaa 25560
cagagtgaga ccttatctct aaagaaaaac aaacaataaa aaattttaaa aataatttct 25620
atgaattaaa aataatttta aacacaactg catatgaaga caacaaagga aaactctcag 25680
gaaacactga aatatgaaaa tcaagtgaga ttagagcaaa taaggatgtg tatgggaagg 25740
ttctgtagaa gacagattga ggcccaaaca gagagagctc taaatacatc atgaaggtta 25800
ccagaaatgt gagaaattcc tgaagaagag ggaagaagca aatcctctcc aaatttagtt 25860
cacttagttg ataatcatta gttgattccc agtagagtca gtcttttatc atcagtgcca 25920
ccactgttgt tctctgcatt aacaaaggag atattaatct ggaaagctgc aatcattttc 25980
actgtagaat cagcctttta ttttttaggg ttttttaatt tttttttttt aggacacctt 26040
catttaagat cacttcatat ctcctctggc ttttgcaaat gctctttggc tgatctactg 26100
tttccaccac tgtcctcaac attttttagt atattattta atttatgtat gtattggtgt 26160
ccactgatta ttgtttgcct tcccccattg gaacacagat tctataaaag tagggatctt 26220
tattttgttt accactgtat tccaggtgcc tagaacagtt cctttcacat tgttggtgct 26280
caaaaagaaa aaagttaaat gaatgaatat cagcagcaag agcattttga ggagaaagca 26340
aaggtgtaac tgtgggggtc tccattaatg tatgtatatc atcctcttat acatttgtcc 26400
catcacccgc tagccctgga actctcatta tttttttttc tggtaatgca ggctccaact 26460
caactggcaa tgagaatatg aactgaggca actgtatttg aaaaatgaaa gaatataggt 26520
gatatgggtt taaagaattc agtatttgtg tatttttcca ataagtacat gcttatgagc 26580
atagccttac aaaataacaa aaataatttt ttacatttac tcacacactt accatttcca 26640
gcactcttca ttcctttgta tagatccaaa tttgtatctg gcatcatttt acttctgcct 26700
aaagaactaa ctctaacatt tttttatagt gcatgtctct cagattttct ttgtctgaaa 26760
attactttat tttaactcca tttctgaaat acattttcag tgggtattgt attctgggct 26820
gacttttttt ttttttccca gtgcttgaga gatgccattc cattctcttg tggctttcat 26880
tatttttgat gaaaaatcag ttgtaagtct tactcttgtt cctctgtaca taatctgact 26940
gctgcttcta aaattttatc tttattgctg gtttttagca atttctgtgc cttgttttgt 27000
ttttgttatt tagtgtttgt tctgcttggg attggttgag cttggatctg taggtttata 27060
cttttcatca aatacgaaaa attttggtca ttatttttca aatatttttt ctactcctcc 27120
ctcctcactt tttccccctc aaacagcagt tacatgtatg tcagacaact tgctattatt 27180
ctataagtca ttgagacaat gttcattctt ttttattttt aatttttgtg ggtaaatagg 27240
tgaatatatt taggggttca tgagatgttt tgatataggc atgcaatgta aaataagcac 27300
atcatggaga atggggtatc tattccctta agcatttatt ctttgaatta aaaacaatcc 27360
acttacactc ttatcacttc tcagcctttt gggataagat catgtgtaaa aacaatgtac 27420
ttacactttt cattttaaaa tgtacaatta agttattatt gactatagtc accctgttgt 27480
actatcaaat agtaagtctt actcattcta actaattttt tataaacttt aactataccc 27540
acttctcctc ccacctccca ctccctttcc aacctatggt aaccatcctt ctatactctg 27600
ttcatgagtt cacttgtttt gatttttaga tcccacaaat aaataagaag atgtgatgtt 27660
tgtctttctg tgcttggctt atttcactta acgtaatgat ctccagtgcc atccatgttg 27720
ttgctaatta ctggacctaa ttcttataca tggatgaata gtacatcatt gtgtagatgt 27780
accacatttt ctttattcat tcatctgttg atggagactt agattgcttc caaatcttag 27840
ctatagtaag caatgctgca acaaacagga gtgcagacat ctctttaata tactgctttt 27900
ctttcttttg ggtatatatc cagcgatggg attgccagat catacagtag ctcaattttt 27960
agttttttga ggaacctcca aactgttctc cataatggtt gcactaatgt acattcccac 28020
caacagtgta caagggtccc tttttctcca catcctcacc agcatttgtt attgcctgtc 28080
ttttggatat aagccatttt aactggggtg agaagatatt ttagttttca tctgcatttc 28140
tctgatgata aatgacattg agcatctttt catatacctg tttgccattt gtctgtcttt 28200
gttggaaaaa tttctgttag ctcttttgcc cattttttta atcggattat taaatttttt 28260
cctatagagt tgtttgagct ccttatatag tctggtgatt aatcctttgt cagatgggta 28320
gttggcaaat attttctgtc attctgtgag ttgtctcttg actttgttga ttgtatcctt 28380
tgatgtacag aggctttgta acttgatgtg atcctatttt tccatttttg ctttggtcgc 28440
ctgtgcttgt ggcatattgc tcaagaaatg tttgcccaga ccaatgtcta gagactttct 28500
gcaatgtttt cctgtagtat tttcatagtt tgaggtctta gatttaagtc tttaatccat 28560
tttcatttga tttttgtata tggtgagaga tgggtgtcca gtttcattct tatgcatgtg 28620
gatatccagt tttcccagta ccatttattg aagagaccct ctctttccca gtgtatgttc 28680
ttggcacctt tgccaaaaat gagttcactg tagtttctgg gttctctctt ctgttctatt 28740
ggtctgagtc tgtttttatg ccagtactat tctgttttag ttacaatcat tctgtagcat 28800
aatttgaagt caggtaatgt gattcctcca gttttgttct tttcactcag gataccttta 28860
actattctgg gtcttttgtg gttccacata aattttagga ttgtattttc tatttctgtg 28920
aagaatgtca ctggtatttt gatagggatt gcattgaatc tgtagattgc tttgggtagt 28980
atggacattt taacaacatt gattcttcta atccatgtat atgggatatt tttccatttt 29040
tggtgtcttc ttcaattttt ataatctgtg ttttatagtt ttcattatac agatctttca 29100
cttctttggt caggttaatt cctagatatt taattttatg tgtggctatt ataaatagga 29160
ttacattttt atttcttttt cacatagttc actgttggca tatagaaatg ctactgattt 29220
tttataaact tttatgttat gttcaggtgt ataggtacag gtttgttata taggtaaact 29280
catgtcatgg ggtttgtcgt acagattatt tcatcaccca ggtactaagc tagtacccat 29340
tagttatttt ttctgatcct ctccctcttc ccactcttca ccctcagtag gccccagtgt 29400
ctgttgttcc cctctgtgtg tccatgtgtt ctaatcattt agatcccact tgtaagtgag 29460
aacatgcagt atttggtttt ctgttcctgt gttacttttc taaggataat ggcctccatc 29520
tccatccatg ttcctgcaaa ggatataatc tcattctttt tatggctgca tagtattcca 29580
tgatgtatat gtaccacatt ttcttttttt ttcccttcaa cttttatttt aagttcaaga 29640
gtacatgtat gtacaagatg tgcaagtttg ttacataggt aaatgtgtgc catggtagtt 29700
tactgcacag atcatcacat cgcctaggta ttaaggccag catccattag ctattcttcc 29760
tgatgctctc cctccctcac cacaccccct ccgacaagcc ccagtgtatg ttgttgcccc 29820
ctcacatgtg tccatatgtt ctcatcattc agctcccact tataagtgag aacatgtagt 29880
gtttgggttt ctgttcctgc attagtttgc tgaggataat ggcttccagc tccattcatg 29940
tccctgcaag gaacatgatc tcattccttt ttatggctgc atagtattcc atggtgtata 30000
tgtaacacat tttctttatc tagtatatca ttgatgagca tttaggttga ttccatgtct 30060
ttgctattgt taatagtgct gcagtgaaca tatgtgtgca tgtatctttg taacagaatg 30120
atttatattc ctttggatat agacccagta atgggattgc tgggtcaaat ggtatttctg 30180
cttctaggtc tttgaggaat tgccacacta tcttccacaa tgattgaact aattcatact 30240
cacaccaata attccttttt ctccacaaca ttggcagctt ctgttgtttt ttttgacttt 30300
ttaataatag ccattctgac tggcatgaga tggtatctca ttgtggtttt gatttgcatt 30360
tctctaatga tcagtgatgt tgagcttttt ttttcatatg tttgttggcc agatgtatat 30420
cttcttttga gaagtgtctg ttcatgtcct ttgcccactt tttaatggtg ttgtttgttt 30480
ttcttgtaaa ttggcttaag ttccttgtag actctggtta ttaaaccttt gtcagataga 30540
tagattgcag aaatttttct cccattcttt aggttgtctg tttgctctaa taatagtttc 30600
ttttgctgtg cacaagctct taagtttaat tagattccat ttgtcatttt tgctttcatt 30660
gcaatcactt tcggcatttt tgtcatgaaa tcttttcctg tgcttatgtc ctgaatggtt 30720
ttgcctagac tttcttctag agtttttttt tatagttttg ggttttacat ttaagtcttt 30780
aatccatctc cagttaattt ttgtatgtgg tgtaaggaag gggtccagta ttaattttct 30840
gcatttggct agccagttcc cctagcgcca tttgttaaat agggaatcct ttccctattg 30900
cttgtttttg tcaagcttgt caacagtcag atggtggtag gtatgtggtc tgatttctga 30960
gctattttgt ttcattggtt tatgtgtctg cttctctaca actaccatgc tatttgggtt 31020
actgtagcct tgtactatag tttgaagttg ggtagtgtga tgcctcaagc tttgttcttt 31080
ttgcttaata ttgccttggc tattagggct cttttttggt tccatatgaa ttttaaaatg 31140
attttcttct aattctgtga agaatgtcaa tggtaattta atgggaatag cattgaatct 31200
ataaattact ttgggcaata tggccatttt catgatattg attcttccta tccatgagga 31260
tgaaatgttt ttccgtttgt ttgtgtcttc tctgatttct ttgagcagtg gtttgtagtt 31320
ctccttgaag aggtccttca cttcccttat tagctgtatt cctaggtatt ttattctttt 31380
tgtagcaatt acgaatggga gttcattcac aatttggctc tctgcttgcc tgttgttggt 31440
gtataggaat gctagcaatt tttgcacatt gatgtttata tccttagtct ttgctgaagt 31500
tgcttatcag cttaagaagc ttttgggctg agacaatggg gttttctaga tataggatcg 31560
tgtcatctgc aaacaaagat aatttgactt cttctcttcc tatttgaata ccatttattt 31620
ctttctcttg cctgattgcc ctggccagaa cttctaatac tatgttggat agaaatagtg 31680
agatagggca tccttgtctt gtgccagttt tcaagggaat gcttccaact tttgcccatt 31740
cagtatgata ctggctgtgg gactgtcata gatggctctt attattttga agtatgttcc 31800
ttcaatacct agtttattga gagcttttaa catgaaggga tgttgaattt tatcgaaggc 31860
cttttctggg cctattgaga taatcatgtg gtttttgtct tttattctgt ttatgtgatg 31920
aatcacattt attgatttgc atatgttgaa ccaaacttga atctcaggga tgaagccaac 31980
ttgatcgtag tggatacgct ttttgatgtg ctgctggatt tggtttgcca gtattttatt 32040
gaggattttt gcctcaatgt tcatcaagga tattggcctg aaattttctt tttttgttgt 32100
tgtatctctg ccaggtttgg tatgaggatg atactggcct caagaatgag ttagggagaa 32160
gtccttcctt ttcaattttt tggaaaagtt tcagtagaaa tggtaccagc ttttctttgt 32220
accgctggta gaattcagct gtgaatctgt ctgatcttgg gctttttttg gttgttaggc 32280
tatttgttac tgcctcaatt tcagaacgtg tcattggtgt attcagggat tcaatttctt 32340
tctgcttcag tcttgagaag gtgtatgtgt ccaggaattt atccatttct tctagattct 32400
ctagtttatg tgcatacagg tgtgtgtagt attctctgat ggttgtttgt atttctgtgg 32460
gatcagtgat gatatcccac ttaacatttc tgattgtgtc tgtttgattc ttctctcttt 32520
tgttctttat tagtctagtt agttgcctat ctttttatta attttaaata aaacagctcc 32580
tggattcatt gatttttttg aaaggttttt tgtgtctata ttttcatttc aactctgatc 32640
tgatcttggt tatgtcttgt cttcttctag ctttgaaatt tgtttgcttt tggttctgtc 32700
attcttttag ttgtgatatt aggttgttaa cttgagatct ttctagcttt ttgatgtggg 32760
catttagtgc tataaatttt cctcttaaca ctgcttcagc tgcaccccag agattctggt 32820
atgttgtctc tttgttctca ttagtttcaa ggaatttctt gatttctgcc ttaattttgt 32880
tatttaccca ggagtcattc aggagcaggt tgttcaattt ccatgtagtt gtgtggtttt 32940
gagtgaattt cttaatcttg agttctaatt tgattgtgct gtggtcagaa agactgttat 33000
gatttcaata cttttgcctt tgctgaaaaa gtgccatgtg gtgatgagaa gaatgtatat 33060
tctgttgttt ttgggtggag agttctgtag atatctatca ggtcctcttg atccagagct 33120
tagttcaggt cctgaatatc tttgttaatt ttctgtctca gtgatatgtc taatattttc 33180
agtggagtgt caaagtattt cactattatt gtgtgggagt ctaagtctct ttgtaggtct 33240
ctaagaactt gctttatgaa tctgggtgct cctgtattgg gtgcatatat atttaggata 33300
gttagctctg cttgttgaat tgaacgcttt accattatgg aatgcccttc tttgtctttt 33360
ttttatcttt gttggtgtaa agtgtgtttt gtcagaaact aggactgcaa cccttgcttt 33420
tttctgtttt ccatttgctt cataaatttt tctccattcc cttattttga gcctatgtgt 33480
gtctttgcac ttgaggtggg tgtcttgaag acagcatact gatggccctt ggctgtttat 33540
ccagcttgcc attctgtgac ttttaattgg gggcatttag cccatttata tttaaggtta 33600
gtattgttat gtatgaattt gatcctgtca tcatgatgct agctggttat tttgctgact 33660
tgtttttgtg gttgcttcat agtgtcactg gtctgtgtac tttagtatgt ttttgtagta 33720
gctggtaaca gtttttcctt tccatattta gtgcttcctt caggagtgct tgcagggcag 33780
cctggttgtg acaaattccc tcagcatttg cttgtctgaa aaggatctta tttctccttc 33840
acttatgaag cttagtttgg cccgatgtga aattctggat tggaaatatt tttctttaag 33900
aatgttgaat attggtttcc agtctcttct ggcttgtaga gtttctgctg aggagtccac 33960
tgttttctgt tgggcttccc tttgtaggtg acctggactt tctctctggc tacccttagc 34020
attttttttt tcattttcac cttggagaat ctgatgatta tgtatcttgg agttgatctt 34080
cttgtggagt atcttactgg ggttctcggc atttcctgaa tttgaacttt ggcccatctt 34140
gctagcttgg agaagttttc ctgtatgcta tcctgatgca tgttttccaa ctcagttcca 34200
ttctgcccct ctctttcagg taccccagtc aagtcatagg tttggtctct ttacataatc 34260
tcatatttct ctgaggtttt gttcattcct tctcttttta tttgtttctg tattcttgtc 34320
tgcctgtcta tatgcagaaa gatagtgttc aagctctgaa attctttcca ctgcttggtc 34380
catcctatgg atacttgtga ttgcattgtg aagttcttgt gtattacaag aactttattt 34440
ttttatcttt atccagtcta ccattgatgg gcatttaggt tgattctatg tctttgttat 34500
tgtgaataat gctgtaatga acatactaga atgattcatg tttatttggg taaatgtgtg 34560
ttgatttcgt atcctgcagt tttattgaat ttatcagttc taatcatttt tcttgtggag 34620
tctttaggtt tttccaaata taagatcata ttgtctgcaa acaatgatca tttgagttat 34680
tccttttcaa tttggatgct ttttatatct ttctcttatc taattgctct agctaggact 34740
tccagtagta tgttgaataa cagtgatggc agtgggcatc cttgttgtgt tccagatttt 34800
agaggaaagg ctttgtcctt cccctatgcc ccaggtaggt ccaggagtca aggactagag 34860
tccaaaacct tagaagtcta cctggtattc tattatactg tggctgagct ggccctcaga 34920
ccacaagaca cagtccttcc cactcttctc tcccctttcc aaaggcagag gaactgcctt 34980
tagtagagac agggtttcgc catgttggcc actgccaacc cagcccatga ggaggactgc 35040
cagactactg ctgatgttcc cttaaggccc aagttctctt aaatcagctt gtcctgaatg 35100
ttacctagcc tgagactcac ccttcaggac agtgggctcc cctctggccc agggaaggtc 35160
cagaaatgct gcccaagggt caagtcctgt aatcagggac tccaagagcc ctcttggtat 35220
tctaaccccc tgtatctgtg gtggtaccta aggtgcaaga caaagtccct tttacatttc 35280
cttctgcttt tatcaagcag aagttttgtc ctgcagccac cacagctggt aatgtactga 35340
gttctacctg aagccaggaa gtctcagagg ctcacccaag gccctcaaca tagtccctgg 35400
ttattgctgc tggttattca gaaccaaggg ctcttcactt agcaggtgat aaatgccggc 35460
agggctgggt cctttccttc aatgcagtgg gttccctctg gcccagggtg tgtctagtaa 35520
tgtcacctgg tttctagggc ctagaatgga ggcctcatga ctctgaccag tgccctatcc 35580
tgctgtggct gcgctggtat cctagacgca agacaatggt ctccccactt ctccctctcc 35640
tattctcaag tggaaggaag gggtctcttt tggagctgta agctgtgtag cctggggtaa 35700
ggggaggggt gatgccaata ctctcttggc tgccccagct ggtgtctcag taggttgcat 35760
gcactcccag tctgctgtct ctgggcctag ttcagcacca ggactcacct aagagttgca 35820
gtccttatgg cctagactgc ttttgaagtt tacttggaga caaagagcac tgtggccttc 35880
actggtgagg tttacaggca ctcaagttta gaccactggg attggtgatt cttctctggc 35940
tagggctgtt ttaaatcctc cctccgtttg cacatttcag ctgagtttga tctagtttgc 36000
ctttctgctc tgatttctgg ttcttatgaa ggtgtttttt tctgtgtaga cagctgttaa 36060
cttggtgtcc ttgcagaggg aatgatcagt ggagccttct atttcgccat cttgatccgc 36120
cgccatatat cattcttatc aatcattttc tgtttatgca cctgaaaata cactggtata 36180
caaaattaag atccttactt tcacagaatt tgtgttctaa tgggggaagt caataatcgg 36240
tggacaccaa tacatatata aattaaataa cacattaaaa ggtgttgagg acatgctggg 36300
catggtggct catacttgta atcccagcac tttggggggc cgaggcgggt gcatcacttg 36360
agatcaggag tttgagacaa gcctggccaa catggtgaaa ccctgtctct actaaaaata 36420
caaaaattag ctgggtatgg tggcaggtgc ctgtaattcc agctactagg gaggctgagg 36480
caggggaatc gcttgaagct gggaggcaga ggttgcagtg agctgagatc ctgccactac 36540
actccagcct ggacaacaga gtgagactct gtctcaaaaa aaaaaaataa ataaaaataa 36600
aagctgttga ggacaatgga ggaaaaggca gatcagagaa agaacattta caaaagccag 36660
agggagtgtg aagcaatttt aaatgaggtc agatttttgg ataatttcta ttgctatgtt 36720
tttaagttaa ccaatgtttc tttttgcaat gtctgatctg ttacattttt atttcagata 36780
ttatattgtt atctctagaa gttctattta gatctccttt ttatctttca attctctcct 36840
cattttgttc atattttgct ttatatccta gagcatattt ataatagttg ttttaaggtt 36900
cttgtgtgat agttatatca tttctgttat ttctgtgtct gatattattt atctattttt 36960
taaaacttta tgggtatagg tcatattttt tcatttcttt gaatgcctgg tgattatttt 37020
gaattttaca ttgttgagca ctggatgttg ttatattcct tttaagagca ttgagttgtg 37080
ttctggaatg cagttgagtt tttacagatc actttgatcc atttgagact ttcctttagg 37140
gtatatccag agtaacatct agtttagagt taatttgttt ttactactaa gatgtggctt 37200
ttctgaggat tttatccaat gtcctgtgta ttttggggtc tctccacact ggctgatgga 37260
aacacagggt agtctcagcc ctgtgtgagc tccaggaatt actcagctat tgcctatcag 37320
tgtttttttc ttcaactcca agtagtttct tccagctcat atccaaatca tacttaggag 37380
aagactgggg gggatcctct gcagatttcc aaagtgctct ccccactctc tgtatctccc 37440
tcttcttcat tactctgtcc cacaaattct aaccacctca acatccttaa attccaatcc 37500
attccccctt acctcaggta gaattctagg ttctgattgg ttttccctcc acgtgctgtg 37560
acctggaaat gacctccagg cagtatctct taggaagccc agttgtgtgg catctgttgt 37620
acaatgcctg aaaatgattc tttcatgtgt tttgtctggt tttcaacttg ttcacagaaa 37680
aaagcaattt gcacagcagt taattcttca cagacagaag cagaagttct accaactgca 37740
aaacaaccaa aacaacttgt taaaagacag tatttgtatg actggtcata aattacgtat 37800
agaagaatag agattttgtg agaaagatat gggcctgtac agaggggtga acttgcaaat 37860
gaccatcttg cttggggata gtgtctgttt tcctgatcct aatcactggg aaggattctg 37920
taatctctgt caaataaatt gcaaacacta ccacacatgg ccttgggtct actactgtct 37980
atgacataaa cagtttctcc ctagagactt agttgtgagg gtacaggggg aaggtagctt 38040
ttggaggggc ctggaagacc cttccctttg tgccttcgat tctgtatata tcttgtggtc 38100
agaagtctta ccattaccct ctctgataac tccccaccca ctttcccaat cactaaacac 38160
tttttgaaac cattcaactc tttcctttca atgattgagc ccttcattgt ttcatcagct 38220
cctcttgtgt gaatctctct gaatgtgtgc caagtttgca gtttaatgcc tgtcccatgt 38280
aggagcccaa tatcacggta tataaagttt ctacactgga tatccatgga ctgaagaggg 38340
gcctagcatt cagggttcca agccagtgag tttagcttat ccaagggtac ctctagaatg 38400
tgctcagaaa tttattccaa gtcagagttg catcccccag gactttaggc tcagatggac 38460
aaccccatca tatttacaga atccctcaaa gataatttaa gtttaagatt gtcagcccac 38520
ctggggtgca cagtgttgac cagggtttct taaccttagc actgttgaca tttggggcca 38580
gataattctt tgttgttcag accatcctgt gaattatagt atgtttagca gcatccttgg 38640
catctaccta ctagatgtga atagcatcct tctcttaatt ttgacaacca cagatgtctc 38700
cagaattgcc aaatgtcccc taaaggtgca aaattgcata gttgagaact actggtaaag 38760
aggcactatg gcatgccaag ctctagggag cccacagaag tgcacctctg ggaactaaag 38820
ctgaagaaac ccaagaggcc ccttggtatc ttcttggaag aagttagtcc agagtgtctg 38880
caccatgtgg agtgtatact gggatgacat tgaccttgga atgtaaactc ctgggattct 38940
tgcctctgca gatttggagc agggttttct tcttctctgc ttttcagttt acttatttga 39000
aaatgaggaa tggtgtttac atcacaaaac actgtagtga ggacaaaatg aggttttatg 39060
tatatataca cccatacata tacatataca cttcttccaa atgatataat aatatataaa 39120
cattgaatga ataatggttc aaatataagt gtacttattt gccactatga ttaaaagggc 39180
aatataggaa aaatacattt tcttctaatc catcatgttg taataatcct ccctgtggtt 39240
gcagtatggt tctgtgctag aaggcacaat aggaaatctc taactttaaa aaaaaagaaa 39300
agaaaaaata tctttctagc aattaaaatc tcaactaaat tagaatgcaa ataggttttt 39360
atatttgctt cttaattttg cattcaataa tctgactaga atatgcaata atttaaatgc 39420
cttgatggga gatagtggct tttagttctc ttgggatttc attgtaataa acctggtaaa 39480
taattcagga acatatgaga ggccaatgaa tggtcagcac ctggtgctat attatttgtg 39540
cctaagcaca cagactccaa agatggcact ctccacctgt cactgttgtt ctggcttaaa 39600
catgggccct gtgttcagtg gctattgaga taatagtaat ggatattttt gccttgtcca 39660
attttcctcc acaatcaaag aaaactgtgc taagctgttt aaaaaataca aagcagaagt 39720
ggcagcctct tttagattac cactggtaaa atttcaaatc tattttctct attaagggat 39780
tgattgtttt aaagaattag ggatatggct atcttttcta ctggtgctaa tttgagcctt 39840
tttgcctttc tgtctttgtt ccacaaggct gagcttctct ttagatcaca ttattcatat 39900
tgcaaggatc ttctgagaga aataacacca tcctctggcc agccactcac tctgcaggag 39960
ttcctagagc tccccagttt ctttccctat tgcctgagta gtctatctca cgcctgttag 40020
tctcacagtt taaatacaaa cacacaaaga ctcttgcagg cagcttgggt acctttcttt 40080
gaccccagcc gactggacat agagaacaag agctagagag aacaagagct agagtgaccg 40140
acagatcatg tgtggagaca gcatggggca cctgagccca gcaccatcca ggatcagaca 40200
gaacttaagc catgagctgc ctagaaagat cttgggaggg cactgggttt cccagtatgg 40260
aaaaaagaaa aatgtggctc acaagtctaa gctaaggtct ttacagtact gggccataaa 40320
caggatctga aaagaaactg cagaaaatgt tagatatgct ttatctttgt tttaaaaata 40380
ttatttacta taatggctta aaatatgttg atttaaatat atgatatttg atacctttgt 40440
aatatatata ataaagtgta taataaaata taactatata attaaaatag atgatatttt 40500
aaaacctctc taataaacca tttacgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg 40560
tgtgtgtgtg tatacatgcc tttgtttaac aggtttaatt gctttccttt cttcaggaac 40620
cagagtgagg gtactcgaac agtgactgcc atctggtggt taaccagaat catcaccttg 40680
tgtagcctga tggttactaa gatgtccact cttgactcac atggcatgca ctcgcagcag 40740
gggaccagtt gaaggatgtc tgactttgga gggtcaccag ttgaaggatg tctgatgaag 40800
gagcctagcg aaataaccct ttgcttctac ctgaatgggt tgttcactct ggattctgag 40860
cctgcagcca gctccaaaat ggggcctctg aagaaaagat ttgagttgct cttgtgtctt 40920
agtcaaagat ctacatccct accagtgggt aaccaagact gtgaataagc acacaccaac 40980
aggggcatgt ggtgacatgg agcctgaaat aaactgctct gaattgtgtg acagttttcc 41040
tggccaggag ctggatcgga gaccccttca tgatctctgc aagacaacaa ttgtaagtga 41100
gcagccacag gatgccaggg ctgctcagat gtatgtggtg gtggtggtgt tggggaggag 41160
gaggtggagg gaaaggggga tgaggaaggg gaggagtggg aggagaaact gctcatgcag 41220
gatacatatt tcccagcact tggtgacgat ggggcagttt gtttttgacc tatagaagat 41280
ccttcattcc taacagctcc tccttattct gtcctcagac atcttcccac cacagcagta 41340
agaccatctc ttcattatct cctgtcctct tgggtattgt ttggactttt ctcagctgtg 41400
gacttctgct gatacttttc tttcttgcct ttacaattca ctgcaggaag aacaggtaag 41460
cagcccagtt tctcatcaca catagctcaa tcatgaaatc ccaaatgtta gtatcttttg 41520
gcagcacaag ccactatctg gtctcccact acaggattaa accacatgag acattccctc 41580
tgaaatagtc tacctgttga gaaggggaaa gatctaggtc ggtattgtgc taactactgc 41640
aagggtatcc aaagaagaga atgaagagtc tctctctata atggaggtac aatccttctg 41700
agaagatgag gtatctgtat ttaaaatgaa gaccatgtag aggattccaa aacaacacaa 41760
aaacttgagg acagcacagc agaaccagtc tgggtgagtt agggtttctg caaaagcagt 41820
gaagcactgc tacctggcta tttgctagat aattctggct gactagaaag tcatcagctt 41880
atcagggtaa gtatggctcc caggattcgc aaaagaagca aaatggtgac ttttttctga 41940
agggacttat agcaccttgc cttggatgca atttcatcct tcctcagggc ccatcccatc 42000
tctcccaccc ccacactgta ccctcatcct accacagccg tcccagggtg cctcatgaga 42060
agccctgctc cagccctctc cttagcccac agctgacttc tagatggagc ccacaatcag 42120
aaattaacaa cttcctcaaa ccagccaaac tcgtccagcc ccactccagc cttaccctgt 42180
gtggtgacca agcatgtcgt gctccattgc ctgtggattt gacactcaga tgagaattgg 42240
tcagttgcat tttgggatgc tgttttgcca tgttaggcat ggaggacgtg gaattgttaa 42300
gcagcagtga ttggttgttg ggtcagcctc agcatggtgg tgatacgtgg cactccaact 42360
agagtatacc ccagagactg cctcagccac ttttcattct gttcctcaag cacactacgc 42420
tgactcccat ctcaaggctt ttgtacttac tgttcctgta ctgttccctc tgcctggaag 42480
tcctcctcag atattcccat gactagttcc ttctcatctt ataggtcttg gctccagtgt 42540
cacctcttca gagacacctt ccctgatcat cctatctaaa gtagtatccc tacccatgat 42600
caccccctca tctcattcca tatcctatca gcctgtttta tgttccttat agcaagcata 42660
gtctgctatt accatatttg ttgatttacc tgttgattgt ctgtatcccc taccagaatg 42720
gaattctgtg aacacaggga ctttgcctgt cctcttgtgc ccaccactgt gtctccagca 42780
tttagaacag actctgggat ataataggtg ctcagtaaat atgcatccag tgatcctggg 42840
aggaaagaga tttaaatccc aacggtggct gctgccaaca aagtgactgg gaaaatcatg 42900
catttcaagg ttagagaact atggagtaca gtcttttcag ctgtaacatg tttctataat 42960
gcaaagtaat actcaattgg tattacccag ttggtaataa gaaaattatg tcattgattc 43020
atatgttact tttcccccag caaatcaata atttaaacat tcaggggcaa gctttctcac 43080
agctagtaaa ggaagcttta agcttggcag ttccttccct tggtgcaagt agtgtctggc 43140
ttaatggctt aagaacttgt gtcttcccta caagatgagg ctgtaggagt agatgaagaa 43200
gtggagaaga catttgcctt atgtttaaaa acttcagttg attgttaaag aaagcacaga 43260
tccagagcag atttttaatt ttttgacaat gttatctact ggagatgaat gcccctgagg 43320
acctgtgtct tgagatttaa gactgtagaa gttgactttg atcctgggta caaatgctag 43380
tggacattta ctgggtggta gtgttttagt tggaataatt aatattttat taatactctt 43440
gttacaaagt taactgtttt gagtgttatg accccatcct attttcccca cagtctatta 43500
tttttacata taattttgca gaatacaagg tttatcaagt atttatatat cctgttaaaa 43560
caggaacacc tgtaaacagc attatactag aaacccttat atttctttca ctctattaaa 43620
tattttgctg cctgttttgt ttgcagtggg agcatgactt ggcataaaga ataaaatatt 43680
aagaggtatt gtgaataaaa acacatttta caattaagtg gcttacaagg tcagacaagg 43740
aaagataaaa taacccagtt tcaaaagtgt tttattgaac aatacatttg ttaaaagatg 43800
cagcatcaca atcagatgct ttatttcgtt acaattctgt ggtctctaaa tttgggactg 43860
tgtgtgtgag tattcatgtg tgtgtatatg caagaaagga gaggaagaaa aatattttaa 43920
cacaataaaa ataatacaaa aatgtttaaa tccagttgca gatattgaat ttttataaaa 43980
atttcaaaaa ccagtaaaga taaagaaaac ttgaacacta tcaaccaact tgacccaatt 44040
gacatttata ttacctttca cccaacaaca gcagaataca tattcttttg aagtacacat 44100
ggaacattta ccaagatata tcatattctg ggccatagaa aaagtctcat taaatttaaa 44160
agggttcaag ccgggtgcag tggctcatgc ctgtgatccc agcactttgg gaagctgagg 44220
cggatagatc accagaggtc agcagtttga gaccagcctg gccaacatgg tgaaaaccca 44280
tctctactaa aaatacaaaa attagatggg tgtggtggca tgcacctgta gtcccagcta 44340
cttgggaggc tgaggcagga gaacccggga ggcagaggtt gcagtgagct gagatcatgc 44400
cactgcactc cagcctgggt aacagagcaa gactctgtct caaaaaaaaa aaaaattaaa 44460
ggattcaagt catataaact atgttttctg acaatgaaat taaaatggaa atcaataaca 44520
gaaagatctc tggaaaatcc tgaaatattt agaaactaca tagaacactt taatccatgg 44580
tcaaaaaaga aatcaaaagg aaaactagaa aatattgacc agaattaaaa tgaaaataca 44640
acctagattt gttggatgcc actaaagcag tattaggggg aaatctagag aactaaaccc 44700
catattagaa aagaagaaat gtctcaaatc catgacctca tcttccacct tacaaacaga 44760
aaaaaagagc aaatgagacc caaagtaagt agaagaaagg aaataataaa gatcaggtta 44820
gaaaataaaa taggaaacag aaaacaatag gaaaaaaaag tcagtaaagc caaaagctat 44880
gaagataagt aaaactgatc aacctctagc caaagtgatc agaaaaaaaa gaaataagat 44940
acaattaccc aaataaggaa tgggagaggt gacatcacta tagattctgt agatatgacg 45000
gataaggtaa tgttgtaaac aactatggta gatagcctct aagatgttct tcgatgattc 45060
ccacctcctt gtagtcacac tcctatgaag tcctctctcc ttgagtatga ggtgaactta 45120
ctaacttgct ttttagtgag atgtcgcttt tggcattagt tcacaaaaac tgtggcttcc 45180
accttagagc tctctcattg tcccactaac tcccactctg tgggaggcca gctgttgtgt 45240
tataagctgt cctgtaaaga ggcccccatt ggcaaggaac tgatgtttcc agcctgcagc 45300
cagcaagtac ctggggcttg ctaacagcca tgtcagtgaa ctttgaaaca ggtgacacct 45360
tgactgtatt gttgtgacac cttgactgta ttcttatgtg aaaacctgag ccacaggcac 45420
ccaactaagc tgtgacttag aaatattacc agttcaactt caaactcttc taaaaaaact 45480
gaaaataaag aagtaattcc caactcattc tatgagggca gtattaccct gatttcaaaa 45540
ttgaatagga aaaagaagaa ggagaaggag aagaaggaga aggagaagga agaggaggag 45600
gagaaggaga aggaggagga ggaggaggag gagaagaagg agaaggagaa gaagaagaag 45660
aagaggaaga ggaagaggag gaagaagaag aagaagaagg gaggaggaaa gctataggct 45720
aatatgtcct ataaacatag attcaaaatt ttaaacaaaa ttttaacaaa ttgagtatca 45780
ccaaatgtta aaaagagaat acatcattgt gacaacgtga ggtttatccc tggaatgtaa 45840
gctttgttta atatctaaag attgatcaat aactcatgac atttaccaac taaaaaagaa 45900
aactatatga tcatctcagt agatacagaa aaatttttga caaacttcaa catcaatttc 45960
tgataaagtc tcaacaaaca gcatagaaca gaacttcctc cccattgcgc agcacagctg 46020
ctgtggcaga ttgtggccag actgcttctt taagtgggac cccgatccat cccccctcac 46080
tgggcaggac ctccttgtga gaatttcagc aactccagcc agggttttat ggacagaact 46140
ctgatctctc tgggacagag cccctcaggg gaagggtggc cacagtctct gtggttcagc 46200
caacttagcc tttcctgcct gctggctctg gagagtctgg gcagtctgga caaaagggga 46260
tccccccagt gcagtgcacc cagtccccca aggggcagcc agactgcttc ttgaggcagg 46320
tccctgatcc cattcctcct gactgggtga gaactcccaa agggatcccc agacacctct 46380
tacaggagtg tttgggccag cgtcagtttg gagcaggcag ccatctttgc tgttttgcac 46440
cctttgctgg tgatagtgat acctccaggt gcagaaggga cccaggtgat tagggtctgg 46500
ggtggaccac tagcaaacca cagcagccct gcagaagagg agcctgactg ttaaaagaaa 46560
aacaaagcag caacaacaac ataaacaaaa aagatcccca aaaaaaccca ttgaaaggtc 46620
agcaacctca aagactgaag gtagataagc ccacaaagat aagaaagaat caatgcaaaa 46680
atgctgaaaa ctcaaaaagc cagagtgcct cttctccaaa tgattgtaat acctctccag 46740
caagggcaca gaactgggct gagactgaga tggctgaatt gacagaagta gccttcagaa 46800
tgagggtaat aacgaacttt gctgagctaa aggaacatgt tctaacccaa tgcaaagaag 46860
ctaagaatca tgataaaaca ttacaggagc tgataaccag aatagccagt ttagagagga 46920
acataaaaca cctaatggag ctgagaatca caacgtgaga acgtcacaat ccaatcacta 46980
gtgtctatag ctgagtagac caagcagcag aaagaatctc agagcttgaa aactgtcttt 47040
ctgaaataag acaggcagac aagaatagag aaaaaagaat gaaaacaaac aaaacctcca 47100
agaaatatgg gattacgtaa aaagaccaaa cctacaactg attggagtac ctgaaagaga 47160
tggggagaat ggaaccaaat tggaaaacat acttcataat gtcatccagg agaacctcgc 47220
caatctagca agacaggcca acattcaaat tcaggaaatg tggagaaccc cagtaagata 47280
ctccacaaga agatcaaccc caaaacacat aatcatcaga ttacccaagg tcaaaatgaa 47340
agaaaaaatg ttaagggcag ccagagagaa aggccaggtc atctacaaag ggaagcccat 47400
cagactaaca gtggacctct cagcagaaat cctagaagcc aaagaaactg gaggccaata 47460
ttcaacaatt tttttatttt ttgttttttt gagactgagt ctcgctctgt cacccaggct 47520
ggagtgcagt ggcgcgatct cagctcactg caagctccgc ctcccgggtt cacgccattc 47580
tcctgcctca gcctcccgaa tagctgggac tacaggcgcc cgccaccgcg cccagctaat 47640
tttttgtatt tttagtagag acggggtttc actgtgttag ctaggatggt ctcgatctcc 47700
tgacctcgtg atctgcccac ctcggcctcc caaagtgctg ggattacagg cgtgagccac 47760
tgcgcccggc ctcaacattc ttaaagaaaa gaatttccaa cccagaattt catatcaggc 47820
caaattaagc ttcataagtg aagaagaaat aagatccttt tcagacaagc aaatgctgag 47880
ggaattgtta caaccaggac tgccctgcaa gtgctcctgc aggaagcact aaatatggaa 47940
agaaaaaact taccagccac cacaaaaaca cactgaagta cacagaccag tgacactatg 48000
aaggaaccac ataagcaagt tggcaaaata aacagctagc gtcatgatga caggatcaaa 48060
ttcacacata acaacactaa ccttaaatgt aaatgggcta aatgccccca ttaaaagaca 48120
gagaatggca agctggccaa agagcaaaga cccgtcagca tcagcaaaca cccagatgct 48180
gtcttccaga gacccatctc aagtgcagag acacacatag gttcaaaata aaggaatgga 48240
ggaaaattta ccaagcaaac ggaaaacaga aaaaagcaag ggttgcagtc ctagtttctg 48300
acaaaacaga ctttaaacca acaaagataa aatagacaag ggcattccat aatggtaaaa 48360
ggctcaattc aacaagtagc gctaagtatc ctaaatacat atgcacctaa tatgggaaca 48420
accagactca taaagcaagt tcttagagcc ctacaaagag acttagactc ccacacaata 48480
atagtgaaag actttaacac tccactgaca atattagaca gatcattgag acagaaaatt 48540
aacaaagata ttcaggacct gaactaaact ctagattgaa tggacctgat agttatctac 48600
agaactctcc acccaaaaac aacagaatat acattctttt catagccaca tggcactcta 48660
aaattgatca tataatcaga agtaaaacac tcctcagcaa atgcaaaaga actgaaatca 48720
taacaaacag tctctccaac cacagcacaa tcaaattaga actcaagaat aagaaattca 48780
ctcaaaacca tacaactaca tggaaatgaa caacctgctc ctgaatgact cctgggtgaa 48840
taatgaaatt aaggcagaaa tcaagaagtt ccttgaaact agtgacaaca aagagacagt 48900
gtaccagaat ctctgggaca cagcgaaagc tgtgttgaga gaaatttata gcactaaatg 48960
cccacatcaa aaagctagaa agatctcaaa tcaacaacct aacatcacaa ctaaaaaaac 49020
tagacaacca agagcaaaca aatcccaaag ctagcagaag acaagaaata accaagattg 49080
gagtggaact gaaggagata gagacacaaa aaaaaatttc aaaaaaccaa caaatccagg 49140
agctgatttt ttttgaaaaa aaaaaagtta ataaaataga ctgttaccta aactaataaa 49200
gaagaaagag aagaatcaaa tagacacaat gacaaatgat aggggggata tcaccactga 49260
cctcacagat acaaacaacc atcagagaat gctataaaca cctctatgca cataaactag 49320
aaaatctaga aggaatgggt aaattcctgg gcacaaacac ttgcccaaga ctgaaccagg 49380
aagaaattga atccctgaat agaccaataa tgagttctga aattcaggca gtaacaaata 49440
gcctagcaac caaaaaaagc ccaggaacag acgaatttac agctaaattc taccagaggt 49500
acaaagagga gctggtacca tttcttctga cactatttca aacaattgaa aaggagggac 49560
tcctccctaa ctcattctat gagaccaaca tcatcctgat accaaaacct ggcagagaca 49620
caataaaaaa acaaaacctc ggacaaatat ccctgatgaa catcaataca aaaatcctca 49680
ataaaatact ggcaaaccaa atccagcagc acatcaaaaa gcttatccac cacgatcaag 49740
ttgacttcat ccctgagatt caaggttggt tcaacatatg caaatcaata aacgtaactc 49800
atcacataaa ccacatgatt atctcgatag acacagaaaa ggcctttgat aaagttcaac 49860
atctcttcaa taaactctca ataaactaag tattgaggaa tatacctaaa aataacaaga 49920
accatctatg acaaacccac agccagtatc atactaagta ggcaaaagct ggaagcattc 49980
cccctgaaaa ctggcacaag acaaggatgg cgtctctcac cacttttatt caacctagta 50040
ttggaagttc tggccagggc aatcaggcaa gagaaagaaa taaagtgtat ctaaatagga 50100
agagaagaag tcaaactgtc tttgtttgca gatgacatga tcctatgtct agaaaacccc 50160
atcgtctcag cccaaaacct tcttaagctg ataagcaact tcagcaaagt ctcaggatac 50220
aaaatcaatg tgcaaaaatt gctaacattc ctataaacca acaacaggca agcagagagc 50280
caaatcatga atgaactccc attcacagtt gctacaaaga ataaaatacc taggaataca 50340
gctaacaagg gaagtgcagg gcctcttcaa ggagaactgc aaaccactgc tcaaggaaat 50400
cagagaggac acaagcaaat ggaaaaacat ttcatgctca tggataggta gaatcaatat 50460
tgtgaaaatg gccatatggc ccaaagaaat ttatagattg aatgctattc ctattaaact 50520
accattgaca ttcttcacag aattagaaaa aactattata aaattcatat ggaaccaaaa 50580
aacagcccca atagccccaa tatctttttg cttaggattc taagcaaaaa gaataaagct 50640
ggaggcatca tgctacctga catcagactg tagtacaaga ctacggtaaa caaaacctca 50700
tggtactggt acaaaaacag atacatagac caatggaaca gaatagagaa ctcagaaata 50760
agaccacaca cctacaaaca tctgatattc aacaaatctg acaaaaatga gcaatgggga 50820
aaggactccc tatttaataa atggtgctgc aaaaactggc tagccatatg tagaaaattg 50880
aaagtggacc ccttccttac accgtataca aaaattaact caagatggat taaagactta 50940
aatgtaaaac ccaaaactgt aaaatcccta gacgaaaatc taggcaatac cattcaggac 51000
atagacattt catgacgaaa atgccaaaag caattgcaac aaaaccaaaa attggcaaat 51060
ggggtctaat taaagagctt ctgcacagca aaagaaactg tcatcagagt gaacagacaa 51120
cctgcagaat gggagaaaat ttttgcaatc tatccatctg acaaaggtat aatatccaga 51180
atctacaagg aacttcaaca aatttacaag aaaaaaataa ccccattaaa aagtgggcaa 51240
agggcatgaa cagtcacttc tcaaaagaag acatacatgc agccagcaaa catgaaaaaa 51300
agctcaacat cacagatcat aagagaaatg caaatcaaaa ccacaataag aggtgggtgg 51360
gtcacttgag gtcaggagtt caagactaga tctagaatca gaaataccat ttgacccagc 51420
agtcttatta cggggtatat acccaggaat ataaatcatt ctattataaa gatacatgca 51480
tgcataactt cactgcagga ctattcacaa taacagagac atggaatgaa cccaaatgcc 51540
catcaatgat agactggata aagaaaatgt ggtacatata taccgtggaa tactatgcag 51600
ccataaaaag gaataagatc atgtcctttg cagggacctg gatggagcaa actaatgcag 51660
gaacagaaaa ccaaacactg catgttctca cttataagtg ggagctgaac tatgagaaca 51720
catagacaca tatggggaga acaacacaca ctggggcctg ttggggaagg ttgggggagg 51780
gagagcataa ggaagaacaa ctaatggatg ctgggcttaa tacctaggtg atgggttgat 51840
ctgtgcagca aaccacctgg cacatgttta cctatgtaac aaacctgcac aggtaccctg 51900
gaacttaaaa gttaaaaaaa ttttaaaaag aagagaactt cctcaacctg ataatgtgca 51960
tctataaaaa aacctatacc taacatcatt tttaatggta aaagaccgaa tcctttccca 52020
ttaggatcag aaagaagaca agatatccac tctcacgact tctattcaac actggaggtt 52080
ttagccagtg caataaggta agaaaaataa acaaaagtca cctacttttt aaaaaaagta 52140
agaatgaaaa tatttttacc ctcagatgac ctgatcacct atgtagaaaa tccagtgaaa 52200
catttaaaag gaagaaacag ggcaggcatg gtagctcacc cacccaaagt gtaatcccac 52260
cactttggga agctgagaca gaaggatcac ttgaggtcag gagttcaaaa ccagcctggg 52320
cacagagtga gaccttgtct ctataaaaaa ttaaaaaatt agctgggcat ggtggtgcat 52380
agctttagac ccaaacactt agaaggctga ggtgggagga ttgcttgaat ccaggagctt 52440
gaggctacag tgagctaaga ttgtgccact gcactccaaa ctgggtgaca gagccagacc 52500
ctatctctaa acaaaacaaa actactagaa ctaatacatg agtttagcaa ggttgcagga 52560
tacaagatca atgtacaaca ctcaactgta tttccatata ctaacaacaa ataattgaaa 52620
aagtgaaatt aaaagcaata ccatttacaa cagcatcaaa tagatgaaat atttagggat 52680
aacctaacaa acaatgtgaa atgcctgtac actgaaaact ttaaaacatt gctaagagaa 52740
tttttaaaaa tctaaataaa tggagataca ttgtgttgct gggttggaag actcaatatt 52800
gtttaaatgt cagttcttcc ctagttgatt tatagactta atccaataac agtcacattt 52860
cctttttttg tataaattga caaactgatt ataaaattca tgtgaaaata tgaaggacct 52920
agaatagaca aaacaacttt taaaaagaat gaagttggaa gactaggacc acctgatttc 52980
aagacatatt acaaaactaa cagtaatgca gacagtttgg tactgggcaa ggatagacat 53040
attcatcaac agaacagaat agactacaga aataaatcca catgtatatg gtcaactgat 53100
tttcaacaaa ggtacaaagg caattcagtg gagaagggac agtcttttca gcaaatactg 53160
ctggaacaaa tgtatatcca tatgcaaaaa tgaactttga tctagctaca tgttacacca 53220
tattaagaaa ttaactcaaa atggatcaca gacctattta taaaacctaa acctgtaaag 53280
tttataaaag aaaacatata agaaaaattt tgtgaccttg gaataagcaa atatttctta 53340
ggtacaatac caaaagcatg gtccataaaa gaaaacactg atgaattaga ctttttaatc 53400
attaagaaca tcttctcttt caaagagaat cttaagagaa tgagaaaaag ccacagacta 53460
gaataaaata tttgaaatca tatatctggc tgggtgtggt ggctcacgcc tgtaatccca 53520
gcactttagg aggttgaggt gggtggatca cctgaggtca ggagttcaag accagcctgg 53580
ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa aaaatgagcc atgcgtggtg 53640
gaggcacctg taatcgtagc tactcaggag gctgaggcag gagaattgct tgaactcagg 53700
aagcagaggt tgcagtgagc caagattgct ccattgcact ccagcctggg tgacaacagt 53760
gaaactccat ctcaaaaaaa aaagaaaaaa aaaaactcta aaaacgcaat acagtggtgc 53820
tcccttatct gtggttttgc tttccatggt ttcagttacc tgtggtcaac catggcctga 53880
aaatattaaa tggaatattc cagaaataac caattcatag gttttaaatt gtacaccttt 53940
ctgaggagca tggtgaaatc tcatgctgtt ccactctggc ccacccagga cacaaatact 54000
ccttttgtcc aacatatcca tgccatatac actacctgcc tgttagtctc ttagtagcca 54060
tcttgattat cagattgcct gtcatggtat tgaagtgctt tgtgttcaag taacccttat 54120
tttgcggtgg ccccaaagtt caagagtaat gatgctgaca tattgttata atttggtatg 54180
gtttggctct gtgtccccac ccaaatctca tctcaaattg taatcctcac atgtcaaggg 54240
agggacctgg tggaaggtga ttgggtgatg ggggcagttt ccctcatgct gttctcatga 54300
tagtgaggga gttctcacaa gatctggttg tttgttaagt gtctggccct ttcccctgca 54360
cactctctct ctcctgccac cttgtgaaag tgtgtcttgc ttcccctttg cctttcgcca 54420
ttattgtaag tttcctgagg cctccccagc catgcagaac tgtgagtcaa ttaaacctgt 54480
ttttctttat aaattattca gtctcatgta gtacctttat agcagtgtga gaacagacta 54540
atacataatt gttttattat tagttatggt tgccaatccc ttactgtgcc taatttataa 54600
attaaacttt attataggta tatatgtata agaaaaatca gtatatatgg ggctcagtac 54660
tatccatggt ttcaggcatc cactgggggt cttggaatgt atcccccctc agataagggg 54720
gactattgta ataagaaaac aattcaatat tttaaaatgg gtaaaagatt tcaacagata 54780
cttcaccaaa gaagatatat ggatgacaaa taagcatatg aaaagatgtc caataccatt 54840
actcattaag gaaatgcaaa ttaaaactac attaaaatac cactacacac tcattagaat 54900
ggctaaaatt aaaaagactg agtaaatccc atgttggcac acactgctga ggagaacata 54960
atttggtcca accacttcac tttggaaggc agtctgggag attatttatt tatttattcc 55020
attcctggct gatttttttt atagaaatag agtttcacta tgttcctcag gttggtctca 55080
aactcctggg ctgaagcaat ctgcctgtct tggcctctca aagtgctagc attgcaggca 55140
tgagccaccg cgcccggcca tggcagtttc tttaaaagtt cagcatatac ctatgatgtg 55200
atctagctat gccactctta ggtttttacc caagagaaat gaaactgcat gtccatacaa 55260
agacttgtac gccaatgttc atagcaactt tctttgtaat agccaaaaac tggaaatagc 55320
acaaataccc attagcaagt gaatggctaa acaaattgta gtatatccat acaatagaat 55380
cctgctcagc aatttaaaac atgaattatt gatacttgga agaacaaaga tgaatctcaa 55440
aataattaca ctgaatgaaa gaagccaggc aaaatgacta catgctatgt aaatccaatt 55500
ccacaaagtt ctataaaact aaactaatct attgttaact aatctgtagt gacagaagca 55560
gatcagtcgt tgcctgtgga tgagtagggt tggcaaagag tcaggaaagg aggatgacaa 55620
aggggcatgt ggaagctttt tggggtgatg gatatgttta taccttgatt atggtatttc 55680
acaggtgcat acatatatca aaacttatca aatcatgtac tttaaatatg tatgtcatgc 55740
actttaaatt gtgtgccagt tataccttaa taaagctagt aaaactatta tacattctta 55800
tttttctgag caggttctca tggagaacaa aatacaccat acctagtgtt cgttttcttt 55860
tttttaatta attaattaat tgatttttat tagtgttcat ttcaaaggac cttgctaggt 55920
gtcctaaaac ctatctgatg actttgcctg atactgatga ttttattatg attttaaaaa 55980
atatttttag tagagacggg ttttcgccat gttgggcagg ctggtctcga actcctgacc 56040
tcaagtgatc ttcccacctc agcctcccaa agtgctggga ttacaggagt gagccaccat 56100
gctcagccaa tactaataat tgatatggga gaatgttttg tttttcctag attcctcatg 56160
cagcttaata aggaccataa taacttaact cttagaacaa aggagatatt tcaggcccaa 56220
agggaagcac atctggtgcc tcctctgaaa ttcacaaaat aagggcgttg ttgtaagttc 56280
tgcatgaagc taaacttgtt caaagtttat aagttcaaaa gtaaataaaa ggactatctt 56340
ttattctgag accttatttc aatatcactt gtgataatga ttatagatcg tagctgttat 56400
ttacatattg ctacttctca gggttaaagg tggcatttcc acagcagtat ctgggatttt 56460
attgcctatg aaatcaagaa ggtagagtaa caagaattgt gtagggtatg agcttttacc 56520
ttacatgcaa gttaacaagt tagcctggta atgtttgatg gatgttagct aaagacatga 56580
gactcttggg tcagagaaaa aacacttgat tactcatggc aaaagcagta atcagaactt 56640
aatattgagc ttttactggt ttccatgccc cacgtgccat gaggggaatg aaagtcccat 56700
aatggatgtt tatggatgtt tgcacacaca cagtgggcta ccatttaagg agaggaatcc 56760
tgagcctggt aagtccactg cttttatagt gagttgtaac aagcctgttc tttgtctagg 56820
ggaagatgtt acctgatccc tcaaggttgc tcattacaaa cacaaccctg agaaatggcc 56880
tggataaaga gcagtcagag ccttgcttct tggcatacct gacaagaatg cacagagctg 56940
ctcagggccc ctggtaggtt tgcctcccac actagggact gtgcatggag gcacctgcca 57000
cttctgcctg catcctgggc tagcgtgaca gtcagagaca cagacaccag tgaatggctg 57060
aaatatgttc ctgtggtctt ctcactccac tacaacttcc ttcccagtta gggtccccat 57120
gcaggccctt tgagctgcac ctggcagagt tgagttacat actttcatgt accctgctga 57180
gtttgtcttc tttgccttca gaaattccaa catactacat gagtcatggt tcttggtatt 57240
attgttatac ccttctcaga atctctctga ctccccagat ttcacatcgt tttccatttt 57300
tgtaaaaggc ctcaaggtct ccatgctatg gagaagagtt atactcatct tttctttatt 57360
cttgcattcc tgaaagcctt acattagcat ccaagtgagg tttctctatc aatatcaaca 57420
gtaaatattt agtgaactaa acacctacta tgctcagcat aatgtataaa atatgattta 57480
agggttcctg ggagcttcaa atgcatcacc tgggtgcaaa aacatgagga aaccaaaaag 57540
tacattctgg tggttttttt aatagcattt aaaaaataat gccttgctgc agggatagga 57600
gctgtgctgc tttcatatca attctgttct ctttgtggtt tgagaaactg gagctgaagg 57660
gaaggtgatt gggaataaaa gaaagcagta ctgatttttc tggctaaaag aaagtttgca 57720
cactgtcatg cactattaga atttctggga tcttctttat aatccccggt ttgatggtta 57780
ttggccaaga aggaagaagg ggagctagtc aggcctagaa taattaccag ccatacagca 57840
taatctgggg ctagtgttgc agggtcaagg actgaatgag gcagagtgac caggagcaga 57900
tcctgcaagg ccttgaccaa aaaggaagct aaggttcata gaaggaaaat attgtattga 57960
tcatcaattc tagaggattg ggcatagagc caaaaatagg aggtgtatca tgagatcaaa 58020
agccattggt ggccaagcgc gatggctcac acctataatc ccagcacttt gggaggccaa 58080
ggcgagcaga tcacttgagg ccaggagttc aagaccagcc tggccaacat ggcaaaaccc 58140
tgtctctacc aaaaatataa aaattagctg gccatggtgg cacatgcatg taatcccagt 58200
actcaggagg ctgaggcagg agaatcactt gaacctggga ggcggaggtt gcagtgagcc 58260
gagatcatgc cactgtactc caacctgagt gacagagtga gaccctgtct caaaaaaaaa 58320
aaaagccact ggtatgtagg aatggtgcag gaaaaaagtg caaagcagaa atgaggtgaa 58380
aatatataga actatgaaca ggaatgaggt ctttcttgag tactggctgc cagatggagt 58440
acgagtgggt cagcagaagt taatgaggta ggttaaaagt taatgcatag gaatagtttc 58500
tgcacagtct tctgatgctg tccatcctgc agtcaggcct atatcaatat cagccctaga 58560
tgaagtggtc acaccctcct ttgtgcacct actgttacaa atagtcatgg ctgtcattac 58620
tccatcacag ctgatggcac ttactaggtt gagagaagcg gggctctgtc tcccttacca 58680
tacagtgagc tccttgagtt tattcatctt tgtgtttcca ttgtgcctgg actgcgcact 58740
gtttcccgaa tgaacaaatt aactggccta gaatatatct atgatgataa aggtcagttc 58800
ttagattatt gttttcattc tttaactgtt taagataatg tcaactctat gtaaaaattg 58860
tgccctaggt aagcagttgc tttttattat tattctctct ctttcttgat ggttactccc 58920
tctaggagcc caaagcatga cgtccagagc cccagattcc cagccatcct ggttgtgacc 58980
cttcattctc aactttcatt tcaatcttag tatgccatga aaagccgtct gcttttgaag 59040
cactatcagc cacagagttc tgtactttta gaaggccttc tcatagtcag attctcacaa 59100
atatacctat tgtttcaata aatatttatt gaattggcca gcaatgtttc agatactgtt 59160
ctaggtgctg gggttacatc aaagaacaag gtaggcaaaa tcactaccct cgtggacttt 59220
gctttcctgg agggggaata ggcaggacat aaaataaatt gtaaactatt cgggatgtta 59280
gtgatcagag aagaaaagta aaacagggac agtgaatggg gactgtcaga gtggtagttg 59340
ctattcaaga tcatttgacc aaggaaggcc tcgctgagga agtaacattt gagaatagac 59400
ttgaaaggca taaaaaaaca agtcattagg taaaaaccat tccaggcaga aggaacaaat 59460
aatgcaaagg gccagggatg gaaacatctg tagtgttcag gggaaagcaa ggaggccagt 59520
gtgactggag cagagtagat taggcaaaga acaggagtag ataagatcag caaggtaatg 59580
ggtgccacat cacgtaaggt cacacaggac agtgtaatga ctttggcttt tactctgtta 59640
tggggagcca ttgcaggatt gggagctgtg aaatggcaca ccttgcttac atctaatagg 59700
aaatctgctg ctgcattgag aatagacctt taaattttaa aagagatatc tatggcatta 59760
ccttaaataa agtcatgctc cttggagtgc ctcaattcat gtacattaat gggtaaaagt 59820
ggaattcaag aaaccctgga aatgtatggg ggagtcctct ttgtttctcc tctgctcatg 59880
tctggtgggt gagcactaac gccatctctt cctaagcgag ggctccctag cagagcaccg 59940
tgcacatgga ttcttcctat gctctgcatt ctttgccaca gggatgccat aatttggcaa 60000
tatgcagtag agactgcctc aagaggcagt tcccttcttt atctaagcca agagaaattt 60060
ggttctgcaa gtaacaagta attactgctg atgacattcc ttgtacacac ttgaagagag 60120
cgtggaccgc aaaataaaaa ctggagcaaa aagggactat cagataatcc agattaaaga 60180
ttggaaagga ggaaaacaca ttatttacac atacaacact tgattttatg agtagagaac 60240
acaacttatg tgtatgtacg ttgtacactt gattatatgt gtagagaatt caaaagtgtt 60300
cagataaatt atttagactt aaaaagagac aaataatttt gggaaggtga tagtggcagt 60360
agtagcatag gttttagata ttcctgaatc tccacataaa aacagcaact agatagaaga 60420
cacaaaactc atgggcaaca aaataaaatc catttacaag aaaattagat gatgaggtat 60480
tcttatgatc ctcaaaatat aaccggttgg ggaaagacca cccacagcca caagagctgt 60540
gttatttgtg tctacgtagg agaaataaga gagaggcaat ggacatctga cagacctgag 60600
aacagagaac tcaaaatagc ccaaaggtat tcactggaaa gcatgggtgg ggcaatttga 60660
gatcagcagc tgaaacttaa taaggggtga gtgcaaggga tccacctctg gaaggtctaa 60720
aaggaatgca gcagtctagc tgctgtgaaa tttctagact gatctggtgg ggctcccttc 60780
caagatagga tctcatgaag aagagaaact gtggggagta ttgagctcaa aattgagcag 60840
aatgaagaca atacagatga agaaggaaga ggaatatcca aatgaaagca tatcagagtc 60900
aggaaatctc cttggaaagc aagccagagt attttttaac accatattaa tacaatatag 60960
caaaggaacc atgtgaagtt agaaaagcta tctgaaccaa atgtcttttt aaaatcacat 61020
aaaaactaaa ttcacaccca caaaaatcta cagcaggaaa atatcaaggc caaatccaac 61080
acaacattat taacctaaga aagagaataa ggggaatatc tgcagacaat gaaagcatgc 61140
caaaaagata tgattgaaaa tagattgaga ccctaatgta ctatttcagg tgcattcaaa 61200
gacattgaag aagtcatata agacatagaa aagcaacata aatcaaatta ggaagctcag 61260
aaatgagaca attcaagaaa aaattagaaa taaacatcta aaaatgaagg ctgatctaga 61320
aggaactcaa caacaaatga atacaacata attctttaac ataaataaaa ggtagaaagg 61380
aagaaaattt tttaaatgga atgaaaaaag atttttaaaa agttttgaaa gaaaacaaca 61440
aatattgaaa ataggcaaaa aagatcaatt tatcaataat aagagtccct gaaaaagaaa 61500
ataaaagcaa ggaaagaaaa caagtataaa acaaacaaaa ccctctaatt taagaaaact 61560
gaaaatttga aactacgtat ggaaagaaca cactgtgtac ttgagtatat cataatgact 61620
aagttcagca gagttgttgg atgaaaggtc tatgtgtaaa caccatttta tgtaacattt 61680
aaacaaattt tttagatcat ttaaaacagc ataaaaaata taaaatccta tttgtgacgg 61740
ctttctagtg tgtcaacttg actaggccaa actacatttc ctagaattct ctttcttgta 61800
tgttttctga ccacaaagga gattctttct agatttggaa agctaaggga agttccagcc 61860
atcttatagc acacacattg ttgcgaacct gctgatccac ctactggggt gaagcagagc 61920
tggacatgca attgctctac cttcccctgg accctccatt aacttgtcag gcccctgggc 61980
caggtgtgtg tgattagctc cacgacaaag ggccacagct tctgcaggat atactcatta 62040
cctagatcag aggcaacaat aactgacatg ggtttcagtc tcttcacagg ggtgtgagca 62100
tgctctaatc tcttgatttt ccctcctgac tgcctgcctt gtagacttca agctctagca 62160
tcagatgtgg agacaacagc cttacagaga ctgcttaaag agctcccaaa attgcataac 62220
tcaactgcct gtgacacatc catatatctc tttttgaatc ctggctaata cagtaggaaa 62280
agatatgcat tatctctata tagaaaatca taaaatattt tgagaggaat taaattctat 62340
attcattgat cagaagactt aatattgtaa aaatatcatt tctccccaga ttgatatata 62400
ggttcaatgc aatagaaatt ccaacaactt gcatatgtgt gtgtgaaact tgacaagcta 62460
aatctcaaat ttatacggaa attcaaaggg ctaaaaatag gctggaaaga aaaggacaag 62520
ctgggcgcgg tggctcacgc ctgtaatccc agcacttttg gaggccaagg cgggcagatc 62580
acatgaggtc gggagttcga gaccagcctg gccaacatgg cgaaacaccc tctctactaa 62640
aaatacaaaa atttgccggg catggtgggg ggcgcttgta atcctagcta cttaggaggc 62700
tgaggcagga gaatcacttg aacccaggag gcagaggttg cagtaagcca agatggcacc 62760
attgcactcc agcctggatg ataagagtga aactctgtct aaaaaaaaaa aaaaaaaata 62820
ggacaaagtg agaggatttc ttcttctgga tatcaatatt tactataaag ctagtaatta 62880
aaacctgcta aatatggtat tggagcaagg agagacaaat agatcaatag aacagaatag 62940
agagaatcca gaaagagtca aggatatata gatgcttttc aataaatggt gcagggtcag 63000
ttggctatcc acatggagaa aaaagtgcaa cctgaatcca cctcaacaaa attacttcca 63060
ggtgaactac tgaaatggaa aacaaaaaaa cttcaggaaa gtcatagaag agagtatctt 63120
tatgaactag ggacatgaaa atatgttaaa cagaacacaa caagtattat tcataaggga 63180
aaatattgtt aaattgctct acattcgttc aggagcagcc tgggcaacat ggcaaaatgc 63240
cgtctctgct aaaaatacaa aaatacagcc aggcatcgtg gtgcatgcct gtggtcccag 63300
ctactctaga ggctgaggtg ggaggatcac tggagcctgg gaggcagagg tcacagtgag 63360
ctgagatcac gccattgcac tccagcctgg gtgggtgaca gaggaagacc ctgtctaaat 63420
tgaaaaaaaa aaaaaagctc tacattagaa attgagaact tctgttcatt aaggacatca 63480
ctaaggaaaa aggcaagcca tagactggga caatgtattc acaatgcata tgtcatcaaa 63540
gaatctttat tcagaataaa aaagtgggaa tctatatgaa aacatagaaa atccactttt 63600
ttaaaaatgt gcagtcttat gtttatcaca gcactgttca cagtagtaaa gtcatagaat 63660
ccatctaagt gtccatcaac agatgattgg attaaaatgt ggtatatttt tgccatggaa 63720
tactatacac ctataaaaat aaatgaaatt atgtcttttg cagcaatgtg gatggaactg 63780
gaagccatta tgcttactga aatgactcag aaacagaaaa tcaaaaacca catgttctga 63840
ttgataagtg ggagctaaac agtgggtata cacggacata caaggggcat aatagacact 63900
ggagactcca aatggtggga ggatgggagt gggtgaggga tgaaatacca cctttcaagt 63960
acagttcagg tgattggtac acttaatgcc cagatttcac cactgtgtaa tatatccatg 64020
taacagaact gcatttgtat ccctaaatcc ataaaaataa aaaaatttaa tttcaaaaaa 64080
taaaaaatgt gcaaaagata tgaacaggta catcacaaaa gaacaaatcc agatagccaa 64140
taaacaaatg aaaaagggct caacttcatt agtcatcaga gaaatgcaaa ttaaagccac 64200
agtgtgataa tactacatac tcacttgaat gtctgcaatt aaaaaaaaga ctgacaaaac 64260
caagtgttga gaaggatgta gaacaactgg aattctcatg catagtgtgg aagtgtgcat 64320
tgatacaatc acttttgaaa actgtttagc agtatctact aaacttgaac atattcatac 64380
cctgtgtcct agcaattcca gcaaaattgc atacatatat tcaccaaaat aatgcactag 64440
aatattcata gcaacactat ttgtaatagg cccaaattgt aaactgtttg aatgtccatc 64500
aacagttata atatctattt ataatgtcca atatatcaca gtatactcca tgccacaata 64560
tagatggctc tcacaaaaat aataaatagt gttgagcaaa ggaagccaga aaaagagatt 64620
ataccctatg ttactctttt tacatgatgc acaaaaacag gcagagctaa tctaagatgt 64680
tagaagtcag attgggtggg tggagaaaag ggagaataga gcaagaggaa gacttctgaa 64740
gcactaataa tatgtttttt gacttgcatg ctggttgccc aggtgtgtca gtttttgaaa 64800
attcagtgaa ttatacattt atatatatgc atttttgttt atgcatattt ttcttcagca 64860
aaagtttaaa aaataatctt tgggcttcct gaaaagataa aaaggaaacg tttaaaggat 64920
acatgtcaat tttttagcag agacaaaatt tttaaatact attttctgaa aaaaaattct 64980
ccctcacagc tttatattta ttattaatat tgaaggatat aatgaatagt tttactgtaa 65040
atgcagaagt aaattttata agacttgttt atggcaccat taggaatagt ttttaaaaat 65100
cagaacttgt gtttatcaaa agacactatt aaatgacacc aaaagcacaa gtaacaaaag 65160
aaaaatgtgt ttaatatcat caaaattaaa aatttctggc caggcaccgt ggctcacgcc 65220
tgtaatccca gtactttggg aggccgaggc aggcagatca caaggtcagg agtttgagac 65280
cagcctgacc aacacggtga aaccccatct ctactaaaaa tacaacaaat tagccaggca 65340
ttgtggtgcg cacctgtaat cccagctact tgggaggctg aggcaagaga atcgctcgaa 65400
cccaggaggt ggaggttgta gtgagcgaga tcttgccact gcactccagc ctgggtgaca 65460
gagcaagact ccacctcaaa aaaaaaaaaa aaaaaaaatt ctgtgcttca gataacacca 65520
ttaagaaagt aaaaagaacc tacagaatga agaaaacgtt ttcaaattat ataatagacc 65580
tgataaggga ctcacatcta gatatataaa gaatgcttac aactcaataa tacaaagaca 65640
aataaaacaa tttttaagtg ggcaaagaat ctgaatagaa gtatctcaaa aaagatatat 65700
gaatggccag taggcacatc attaccccta agggaaatca aaatcacaat gagttaccac 65760
tttgcatccc ctaagatggc tataatataa aaattaacaa gtgtttgtga ggctgtggag 65820
agattagaac cctcattcac tcctcctagg gatgtaaaat agtgtctgag ctagggaaat 65880
agtttggcag tttcccaaaa tgttaaacat agggttacca tatgactcag tgattaagct 65940
cctaggtata tactcaagaa aatcaaaaca tatgtccatg taaaaacttg tacatgaata 66000
ttgatagcag cattgtttat aatatcccta aaaggaaaca acccaaacat gtatcaacta 66060
ttgaatggat aagtgaaatg tgttatatcc atacagtgaa atattattca gcaattaaag 66120
tgacacactg actcatgcta ggacatggat gaaacttgaa aacatgatgt taggtgaaag 66180
aagctagtcg caaaagatca catttgattc catttatatg aaatgaccaa aatagacaaa 66240
tctataggga cagaaaggag attcgtggtt atatgtggct ggggaaatgc aaattaaaac 66300
tactaggaga tacataccga tggtatgtat gcttatcttt aaattatctt taaatttttt 66360
aagataataa gataaagatg tgaaactatg aaactctcat ttactcactg ggagggtata 66420
aactggtaca accacattag aaaagaaatt ggcgtatctt ttaagattaa caacacatat 66480
accttgagag ccagcaaatc catttctaaa ttctactcag tagaactatg tgcatattta 66540
tatcaatagg tgtacaaaaa tattcatagc agcattattg taatcaccca aatgttcatc 66600
agaagtataa ggaataaata aattgtggta tattcctgca atgggatatt atatagcagc 66660
tacagttaca cccagcaaca tgtataaatc tcacaaacaa catcaaataa aaaagccaac 66720
cacaaagtag catccactat gattcccatt tatgaagttt aaaaacaggc ataactcaac 66780
tatagtatta aaagtcaata tagtagttca ccttaaggga gaagggaaag agtaaaaagt 66840
ataatatgag gtagaatttt gaggtattgt aatgttctct ttcttgggtt atagttttct 66900
atatgatgtt ttctttgtta caatttactg agctatacat ttttaatttg tacacttaaa 66960
aatacatttc ctggccaggc gtggtggctc gtgcctgtaa tcccagcact ttgggaggct 67020
gaggcaggca gatcaggaga ttgagaccat cctggctaac acagtgaaac cctgtctcta 67080
ctaaaaatac acaacaaaaa ttagccaggc gtggtggcgg gcacctgtag tcccagctac 67140
tcaggaggct gaggcaggag aatggcgtga acctaggagg cggagcttgc agtgagccga 67200
gattgcacca ctgcacttca gcctgggtga cagagcaaga ttctttcaaa aaaaaaatat 67260
atatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtatgtgt gtgtgtgtgt gtctgtgtgt 67320
gtgtgtgtgt attctggccc aagattatag ttttttttaa ggcagtctgt caggggtcta 67380
caattgtatg agttataaat aaggagtgac aatatcttca gtgaactcct gaacatgaaa 67440
accaagggtc gactgcgaat accttcttta catacaacca gacattatgg aatgaatgtg 67500
ttccccccaa attcatatgt tgaagctcta actcccagtg tgtctgtatt tggagatagg 67560
gtctttgggg aagtaattaa agttaaatta ggtcatacaa cctacagaat tggagaaaat 67620
atttgcaaac tgtgcatctg acaatggtct aatacccagc atctataaga aacttaaatt 67680
tacaagaaaa aactaacaac cctatgaaaa agtgggcaga gttaattttt tcatgagcaa 67740
tggaaaaaaa ttaaaaagtc tgaaagcagg caaagaacat gaacagacac ttttcaaaag 67800
aagacataca tgcagccaac aggcatatga aaaaaagctt agtatcactg atcattagag 67860
aaatgcaaat caaaaccaca atgagatacc atctcacacc aattggaatg gctactatta 67920
aaaagtcaaa aaataacatg ctggcaagat cgcagagaaa aatgaacaca tacactgttg 67980
gtaggagagt aaattagttc aacattgtgg aaagcagtgt ggcgactcct caaagagcta 68040
aaaacagaac taccattcac cagcaattcc atttgtggtt gtatacccaa aggagtataa 68100
atcattctac cataaagacg caggcacatg aatgttcatt gcagcactat tcacaatagt 68160
aaaggcatgg aatcaaccta aatgcccatc aatggcagat tggataaaga aaatgtggta 68220
catatacacc atggaatact atgcagccat aaaaaagaat gagatgatgt cttttgtttg 68280
aacatggata gagctagagg ccattatcct tagcaaacca acacaggaac agaaaaccaa 68340
atactgcatg ttctcactta taagtaggaa ctaaatgatg agaacacatg gacacaaaga 68400
gaggaaaaac acacactaca cactacctga gggtggaaga tgggaggagg gagataatta 68460
gaaaaaataa ctgttaagtc ctaggcttag aacctgggtg acaaagtatt ctgaacaaca 68520
aaccccccga cacgagttta cctgtataac aaacctgcac atgtacccat gaacttcaaa 68580
taaaagtctg tgtgtttttt aaggcagaag tcagccccta ccttgaaaga actttctaca 68640
tagatggcta cagtgttact gagcgttttt tttttggtct atcctgaatg tcatgggaaa 68700
acttttaaac tgctctggat caagattagt gcctgtggta tttcatttct cctactcaac 68760
tgttgcagtt acatgatctt agaaattctt tttggcatat tgatgactgt tatcattcaa 68820
gttacatcaa gagagacttc tttctatgag gagctattaa gaccctcttt tggacacata 68880
cacaacttca atttacatct aagacaactt attttaatga aattgcttat ttgtttgctt 68940
tagtccttag attatatgat catttgggca gggactattc tttgaatatt tcctggcaca 69000
tttttgtctc aataaagagg aaggtgaagg aagaaagaaa ggaaaggaag aagggaggga 69060
ggaaggcatt cttgttttct atatcctaaa cctataattt tgtcaaaaaa gaatattaaa 69120
tttgcctaaa atgttaacaa aaaataggtc ataatgatgg ggccctaatt caacagggct 69180
ggtgtcccta taagaggaag aggcattgaa gtttgctctc cctgcatgca caaagagact 69240
atgtgaggac acagcaaaag gacagctgtc tacaaaccag gaagaggcct cgccagaaat 69300
cagcccttga aaaaacctgg gtcttggact ttttgcctcc acaactgtga gaaaataaat 69360
ttctgttgtt taagccaccc agcctgtggt gttttgttat ggcagcccga gcagactgat 69420
acaccagaca ttcactgtat ccaactgttt caccataata gcctttctta ttttgatcaa 69480
attactgcat caggatttga tcttaaattt catgtttcct ttgcttttgt aaatgtagct 69540
gagcatccaa atttcactca gtttggatgc taacaagatt agacagttat ctgacagtaa 69600
tcagtgcctg atcctattct gtgtcttctt ccatcaccat cccactaaag agcttgcatt 69660
ttttgtttct tttagccaga tagtaaacat ttttcaggca ttttgaattt tgccattgta 69720
aatggtgaaa gattctctct ctctctctct ctctctctct ctctctctgt gtgtgtgtgt 69780
gtgtgtgtgt gtgtgtgtgt attaggaggg ggtggtgatc gggatgctaa tctatgcaca 69840
gtgacctttg tttctatctg gctgagcaga tgtaggaatt aatcattgtc actcctggat 69900
ggtgctgctg cagctgtccc ccactgcctt tctgcccctg atagatttat tagtgtgttt 69960
tgtttgctga aaagcatgcc tcagcacaga agaactggca aattagagaa gctttatctg 70020
tgagtataat tttttggaaa catggttttt tctacacatc tgtacctata tactctgagc 70080
tctttaaaaa aaaggaggag gaagagagca aagaaagaaa aggaaaacaa acaggtaata 70140
ttgtttctgt aacatcagaa cgattatttc ccagctgaga atgttcatac tggaacagtg 70200
tcatggccat ccaccttagg attgcagaga accaattgtt ttctaacctc tgtatttctt 70260
tttgcaactg cccaccccct cacccactta actgccaact atcagccaga attttggcat 70320
actttggctc taggcacaag aaaataagtg gtctgggtta cttagtgcta aatttatttt 70380
atagtaggcg tcactacaac cttgagactg taactaacac tttctaggct ccaagcaacc 70440
ccactacgta gatatccctg cagcctcatc aaattcaacc cgtggggata ttgataccgt 70500
cctggatgga aatcagagta gccacacccc tttcaatgtt gggaatctgc caaacaattc 70560
agtataaatt tcctgggcct gggctgtgta ttttcattcc accccacccc caaatcagtc 70620
agcatgccct ggggcagaga ctaaagagcc gccagtgcct attcagagtt ggcttattcc 70680
tttctgatgg cccatcccct ccccgaaatc caagaccttg gccttagata tcttggctag 70740
cctgggcctt tctggtacca cccttcactc tctaggagct ctgagaattt tctgcacttc 70800
ccgacgctgc ttgatagagt gactcacagc ttactctttc attgactctt tctgtatttc 70860
tcttcttcag aatttctctt ctgctgctgc ttttagacat ccttgcatgt tcagtcccta 70920
aatcaccact gcttgttatt actttcatgt tcccaacatc tggcatatgg gtcttaatcc 70980
catgggtcca cccagactca tgaatttaaa ctcttctggt ctaaactctt ccaccaccat 71040
ttgagcctca attctgtgaa cagttttgtc tctaaaagcc acatacctta gtgtaagaag 71100
gcagattaat cctctgaatg tcaacttaac agttaggcct atctcccaag aaagagaaat 71160
gaaaactcct aattagtaat gactcatttt gatcaaataa tcaatttttg gaccattttc 71220
ttaaaactat attttattgc ctgtaactat ttcctggagg ataataatca tccttaaatt 71280
actatgtgtt ttgtgaagtt ggtgctttac ttttcgtgtc ctaaatatgc atatctgaat 71340
ctttaaattg tagcttctct ttcaagtgtt ctaggatttc atttgccatg gttgggatct 71400
ctttgtgatt tgataggttt cgatcacatc ctcactagcc ttctttccaa gccacagaac 71460
ggtctgtctt cattcagtag agaccctgcc attctagttt tctcgctgga atttgttttc 71520
ccatatcctt cttgagcaaa ggtgactaaa gccaaatgtt tcattctggc actttgtgag 71580
acgtgggctt taagctctca aaagaagaga aaatctcata gttttatatg agatatacaa 71640
tgaacaatag taaaatagaa atgttattgg caagaggagt ttttctccaa tatccatgag 71700
taagaattcc ttggacacat aagataacaa gaggaatata cttactctgt tttccttttg 71760
agatattctt tacataccat gaagttttcc tttctaaagt ttgcaattta atagttttta 71820
gtatattcac aagcttgggt aaccaccatc actatctaat tccagaacat ttttatcacc 71880
tgcaaacaaa accttgtacc tgttagcagt ctctcctcat ttctctcttc ctcccacacc 71940
tggaaaccac tagtctactt tctatctcta tagatttgcc tattctggac atttcatata 72000
aatggaatta ttgaacatgg ggccctttgt gtctggcttt tctcatttag cataatctta 72060
gcataatatt tataaggttt ccctgtgttg tagcataaag cgttacttca ttccttttca 72120
tggctgaaca tcccattata tggatattcc acattttgtt tatccattca tcagttgatg 72180
ctatctgttg tttccacttt gaggctctta agaataatat gctgctgtga acatttgtgt 72240
acaagttttt tcatgaacat gtttttactt atctgggtat atacctagga gtggagttcc 72300
tgggttatat ggtgactgtt taacataagt gtagaactgt ttttcaaagt gactatacta 72360
tttcacaatc ccaccaacaa tgtatgaggg ttccagtttc cctacatcat cactaacact 72420
tgttttatta tctgcctttt taattctagc catcctagtg ggtatctcat tgtggttttg 72480
agtcgtattt cccttatgac caatgatgct gagtgtcttt ttatgtactt attatccatt 72540
tgcttatctt ccctggagaa ctgtctattc aaatcctttg acatttaaaa aaattagatt 72600
gtcttggggc cgggtgcggt ggctcatgcc tgtaatccca gcactttggg aggctaaggc 72660
aggcagatca cctgaggtca ggagtttgag accagcctgg ccacatgctg aaaccccatc 72720
tctactaaaa atacaaaaat tagctgggta ttggtggcac atgcctgtaa tcccagctac 72780
tctggaggct gaggcaggag aatcacttga acccaggaga cggaggtttc agtcagccga 72840
gattgtgcca ctgcactcca gcctgggcga cagagtgagg ctctgtctca gaaaaataat 72900
aaataaataa ataaataaat attgtcttgg aaatatactt aaattaattg gcctatagtc 72960
ccagctactc aggaggctga ggtgggagga ttgcctgagc ccaggagttt gatgtttcag 73020
tgagctatga ttatgtcact gctctccagc ctgggtgaca gagtgagccc ccatctctga 73080
aaaaaaaaag gaagaaagag gaagaggaag aagaggagga ggagaaggag aagaagaaat 73140
gctcttaagt caatagttct caaacttggt tcacattaaa gtttcctaaa atcctgatgc 73200
tcaggcttta ccctaggcca gttaaatgat aatatcttgg ggtaggaccc aggcaacagt 73260
tttagaaaca aatctccagt tgattctaat gtttgagagc cattgctata gactacatga 73320
ctaagctgat gataccaata taaaaatgtt aaagatttga taatttagaa attatgccag 73380
gtattaaaaa tgggagactt aactcaaatg tgaatcataa aatgcctaat caggtcaaaa 73440
gatagagttg agatttgtaa taaagattga taaactttcc tataatagga agtttcaaac 73500
cacctatagc tagagaaaat gtctggctgt ggttcttgcc tagtgagcag gaattggttt 73560
tatgaggtaa ccatgggaga gccaataaat gtgagtgatc atgacaatta aatctttaag 73620
cccagataat ttatgtcaat tattcaatgt tcattaagga aagtgaaaaa aaatgagtat 73680
tagctaggag aaatggaaag ggaggctttt gaaaggcata aaaagattgg aggctatttt 73740
aagagacttt attggaagca tagaaaaaga gtatctgaga atttttaaaa atccaatcac 73800
ataaaaatgt gacagtcaca gtggttattg tggagggaaa atgacatctc tcaaagaatg 73860
taaaaagctc cccaagggag agcagggagc ccacagagtg tattaggtta agtacaaaat 73920
aggaaaaaag actttaagaa acactttcga agagagtcca aaacacataa agggattatt 73980
taaaatctat taaaaggaag aagctagaat aacagtggga tcttttgctg agaataaggg 74040
ggcacaggga gtgctgaggc accaaaagac aatagacaaa ctaattatgt gcctctgaat 74100
gtattgagaa agataccaga gtgatagcac attcaaattg cctactacga atggatcagt 74160
agtagttaat tcaatggttt tctgtgtttt gcatatttca agtcaggtag gcagaataaa 74220
tactgattaa tcactggaaa ctcttggtgt ttatcttgag atttctgaag gcctccagaa 74280
gaaatttttc tcgtcttgcc tctccctaaa gccactgccc ttgtcctccc tctcctatta 74340
ccaccaaggc tcctaagtgt atagtctacc ctagtcacct cactttctca tctccaattc 74400
attcttcaac ccattcttct aactccattg aaaggtcatt aaatctgact cattgccaaa 74460
gtcattaaat caacagatcg ctttttagac taaattcttt ctagccttta gatatataac 74520
accattaact gtttcttctg ttcttccttt ctgaaacctc ttttcttaac atttattata 74580
tgtgaatgtc ctggttttac ctgtctactt cttgctagct accttcactg gctccagaat 74640
tacttacgta tttctctttt ttgttttttt tttttaaggc tagtcaagtg aagcagtggg 74700
aatggagaag gaacacagaa atctgtaact ggttgtgatc aattaattgt agacactact 74760
gacttcagac aagccttacc tatttaattt tggtaacact ctgggttcca gtctcgattc 74820
acttcttaca ctatatcctt caccttgttt taacctctcc tgtgacatat cctagtgctg 74880
cctctcttcc cattttctaa cttcatggtt gatatagtca tatagatgtt tcacagttta 74940
ttctgatcca gtaaccaaaa ccagattaat atcttaccag caaacttgct cttcctttgt 75000
gtaattcctg tcgtggttaa tagcactacc atccacccgt tctcattctg gattcctttg 75060
tctccctaca catccggcta gttaccaggt tttagatatt taacctctga aatgtctttc 75120
aaatctttct attgtccatc tccattgccc aaccatagtc ttcatttgtt tttcatctgg 75180
actattgcaa tagtccccta actcatcttg ccgacatttt cagctactga tctcttgcca 75240
gcattttttt ttccccaaac acaatctagt tttaaaatac agacttctac tgcctacata 75300
actccttagg taagtattta aggtcttttg tagtctggcc ctaacataaa atatccactt 75360
ttccccttga aattaagttg tgccctggtc gtacatgaga atggccattc cttgagcaca 75420
ccatgcacat tcctcaccat gtctttgttc atgctcttcc ttgtttcaca actcttctca 75480
tttatcacct gacaaactcc tatctatcct ttaagacaaa tttctgtctc tcaaaatgtg 75540
ggccctgggc cagagcagca gtatcacctg ggaacttgtt agaatacaac ttcttggggc 75600
cccactttag actctgttta atccaaaact ttgtgtgata aggaccagca atgtgaattt 75660
taacaagctc accacatgat tctgatgcat tctaaaattt aagaaccact gttctaggga 75720
acaatttttt tatcaatggc catagcactt tacacatacc tgtattactt actgcattat 75780
ttaataacca tgtttactta ttcacttatt tatctggtct gctaagttgt gagtccccag 75840
agtcaaatac aatggtgctg tgttctgaca cctgccatag tgtctagcac ataacaagtg 75900
cttgataaga attcagcata ctaaaatata cccccttccc tccaggattc agtctagcta 75960
gagtaaatag agagggcaag atcaaatggt gtccaaggca tctactctta aaggtcgata 76020
tacaccacac aaaccaaaag cttacacact gacaataaca aatgtcagca aagtaataac 76080
caacgggtac taggcttaat acctgggtga taaaataatc tgtacagcaa actccaatga 76140
tactaattta cctatgtaac aaatatacac ttgtacccct gagcttaaaa taaaagtttt 76200
taaaaaaata aataaagcaa atgtcagcaa ggatgcagag aagctgaatc tctcatacat 76260
tgctgatgta cctactctgg aagacacttt agaagtttct tataaaatta ttccctcact 76320
gtgcgattca gcagtttcac tcctgtgtat ttaccgtaga gaagtaacta tgtatgttca 76380
cacaaaaagc tgtatgcaaa tgttttttag cagctttgtt tgtaatagtc aaaaactgga 76440
aacattaaca atcaaaaaag aaatcaagaa aacaattcca tttgtaatcg catcaaaaaa 76500
tgaaaacttg ggaaaaaatt ttacctaaaa gatgaaagac ctatacactg aaaactataa 76560
aacactgatg aaataaatga ggaaggcaca aatcaatgga aagatatccc atattcatgg 76620
attgaaaaaa tttatattgt taaaatagcc atactaccaa agcaatctac aaatgcaatg 76680
caatcttacc aaaattctga tggtgttttt cacagaaata tgaaaaaaac taaaattctt 76740
atggaaccac aaaagacccc aaatagccaa aacaatcttc accaataaga acaaagctgg 76800
aggtatcacc ctagcctatt taatttcaaa atctactata aagctatagt aatcaaaaca 76860
gcatgatgct ggcataaaaa cagacaaacc aatggaacag aatagagagc ccaaaaataa 76920
atccatccac ttacagtcag ttgatttttg acaaaagtac caagaaaaca caaaagagaa 76980
aggacagcct cttcaataaa tggtgttggg acaactatgt atccacatgc aaaagaatga 77040
aattatgcct gttaccccag cactttggaa ggccaaggtg ggccgatcac ttgaggtcaa 77100
gagtggagac cagcctggcc aacatggtga aaccctgtct ctattaaaaa tacaaaaatt 77160
agccaggtat ggtggcatgc acctgtaatc ccagctactt gggaggctga ggcaggagaa 77220
tcatttggac ccaggaggca gaggttgcag tgagctgaga tcgcaccact gcactccagc 77280
ctgggcaaca gagagagacc ctgtcttaaa aaaaaaaaaa aaaaaagaaa ttggacattg 77340
gacccttata ccatatacaa aaaatccact caaaaatgaa ttaaaagctt aaatgtatga 77400
cctgatactg taaaaactat cagaataaaa cacaggagaa aagctcctgc cattggtccg 77460
ggcaatgatt ttttggttat ggccccaaaa gcacaggcaa caaaacaaaa catagacaaa 77520
tgggattaaa ctaaaaagtt tttgcacagc aatggaaaca ataaacagag tgaagagaca 77580
acctacagaa tgggagaaaa tatttgcaaa ccatacatct ggtaaggggt aaatattcaa 77640
agactataag gaactcaaat caatagcaag aaaacaaata atccaataaa aagtggacaa 77700
aggacctgaa tagacacttc tcaaaagaaa acatacaaat gtccagcagg tatatgaaaa 77760
aattctcaca tcactgatca tcaagaaatg caaattaaaa ccatgagtta ttagctcata 77820
cctgttagaa tggctcttat gaaaaagaga gatagcaaga gttggggagg atttggagaa 77880
aagggaaccc tatacactat ttgtgaggat gtaaattagt acaactatta tggaaaacgg 77940
tatggaggtt cctcaaaaaa ttaaaaatag aactatcata taatcaagca attctacttc 78000
tgggtgtgta tctaaaggaa atgaaatcag tgtatgaaag agatacctgc actcccatgt 78060
tcactgcaac attattccca atagccaaga tatggaacca acctaagtgt tcatttacta 78120
atgaatggat aaagaaaatg tgagatatat atgtacacat acacacacac gatggagtac 78180
tatttagtct taaagaagga aatcctggca tttgcaaaaa catggatgaa cctggaagac 78240
attatgctaa gtgaaataag caagacatag aaaaacaaat actacatgat ctcacttaca 78300
tgtggaatct aaaaaagttg aactcataga agcagagagt agaatggtag ttgccacaga 78360
ctagggtgga ggtggttgac agaaatggag agatgttggt cagatcaaag agcacaaagt 78420
tccaggtagg acagataagt tgtggagagc tatacagtat agtgtctata attagtaata 78480
acgtgttgta tacttgaaga attccaagag agtatgtctt aaatgttctc accataaaaa 78540
aagataagta tgtgcagtga tggatgttga ttaaattgat ttaataattt taattatttc 78600
acaatatata caaatatcaa aataccatgt tgtataccat aaatatataa tatttgtcaa 78660
ttctgcctta ataaagctgg gagaaaaaaa ctggaaaccc aaatatcctt caacaggtga 78720
atggataaac tgtgggacat ccatacaatg gaatactatc tagcaataaa catgggacaa 78780
agtattgata gatgcaacaa cttggatgga gctcaagggc atatgctgcg tgacagatgt 78840
cagtctcaca agcttacaca ctgtaagagt ccagttctat acaacattct taaaagacaa 78900
atttatagtg atggagaatg ggttagtggt tcctaggagt taggttgggg aagcgtgtca 78960
ctataaagga tagcatgaga gagttgtgtt tataagtgtg tatgtgtgat ggaacagttc 79020
actatcctga ttatgatggt ggtttcgtgt ggtgaatttc atagaaatct atatatgtga 79080
taaatttcat aggactacac acacacacac acaaagtgca cataaaaact ggtgaaattt 79140
aaatagagcc tgtagtttat ataatagtat tgcactaatg tcaatttcct gattttgatc 79200
atgaactctg gttatgtacg atgttattgg ggaaagctgg gcgaaggata cacaggaact 79260
ctctgtactg tttttgcaac ctcttgtgag tcttaaataa tttcaaaatg aaaagctttt 79320
gagaaaaata aagcacaggg atttctgaca aaagctaaat tagaaagcac tgcttgacat 79380
aatgctaaaa caggacccag gaagtggaga gctcactgcc tggtggaggt gggaaagggg 79440
taaagggaag tggagattct tgccttgaag aacatttggt agaacgtggg ccaggcctct 79500
caaacaggtc actcctggct tggggaggag ctaatactaa ggtggaaagg gaaatgaaag 79560
cttacttctc atcagcttcc catatgggga agggggccgg aatctctcct caataggcct 79620
ccattttctc aatagggaaa acggagagaa ggggaaaagg gttcctcttt aacaatggtc 79680
acaaaaggtg atgtgtgcag tgaaagatta aatggtataa gaactcaggc tctggaatca 79740
aacccagcct caaatccagt ggcttgattt tctattgaac tttgctatac cctgtttctc 79800
tatttaaaaa caggggtaat gatactactt aactctgaaa gctgattaca ttagattgtc 79860
tatgtagagc acttagcaac cacctagcac atagataatc agtgttggct actcttttta 79920
atactattct atgccattac caattttcta agacgtaaca ataatacact cagatgattc 79980
tgaccataat gtaatttttg attaaagttt cttcaggatc cttcaatgct tccaactcat 80040
aaattatatc agccctcagt ccctatatat gtaaatacaa tttaaattaa aatagttgtt 80100
actttctatt acatgtcttt tatgtgcttt gcactttaaa tacactattt ctaaccttta 80160
tagcatgcag gataaatact attttcccca ttttcagatg aggaaactgc ttcagagtgg 80220
ttaggcaaat ctccaacatc tataaacaac acagtaaacc taggcagtct gatggcaaag 80280
cccaagctct ttccactaca ctgttacctc agtagtaatc cataaaagat gcttaaacac 80340
atacatattg tctattagtt gttcttttta catcacatta catgggcaga ctctacaact 80400
cctgccacag cctggcgcag acacttccag gccattgctg aagccagtgg agacaccaga 80460
cgatgacaga aaccaagaac ccaaagctga ttgtagcaag aattcagtct ggagttcagt 80520
cagtagataa atccgagagg catcatggaa attgtgccaa ggtccaaggt tcaagccagc 80580
agtcagaatc taaaggggca ggcaaaaccc agcaggaggc tctgcaggct ctgtgccccc 80640
cgggagattc atggcttcct ctctgtctcc tcttgttgac actgccggct ataaatgggg 80700
gctttgtgga tcctcagttg aggaggcagg tgaaaattct tggcctacca gcactactac 80760
aggacgttag aaactagggc aggaagaccc tgggtcttca ttaatcagtg tgatgaaaac 80820
aggccccagg cagttgggtc cactagtggg aagtgaaaga acactgaagg aaaccaggag 80880
tcaggacatc tggatttgct gtcccaacat ggtccctatc tggcgataaa acagcatgca 80940
aatttcttca tctaaaaatg aaggaatcag gtcagatcac tgattttcaa actgtgttcc 81000
tcagaaccca aggactccag tcctgctgtg gagagatagg tgggagcaag caaggccttc 81060
ctgtacagca cgcttccttt catctcttcc aagtactgaa ccttctaatt ctaatgattt 81120
attcagcgta acaggcattt aataagtttc tactaggctc ggggccttgt agaaggtgct 81180
gatggggaca aagctgagta aaacccagtc ccaacatcat gaattcctag attctggctt 81240
aatggggaac cattccagca gctgtcactg ttcaggattc ctctcagatt ccaagataca 81300
ccaaggcccg gagttctgcc acagaattga agataagaaa gagaggaaag aggccgagtg 81360
cagtggctca tgcctgtaat ctcaccactt tcggaggccg aggcaggcgg atcacctggg 81420
gtcaggagtt tgagaccagc ctgaccaaca tggagaaacc ctatctctac taaaaataca 81480
aaataaattg ggcatagtgg tgcacacctg taatctcagc tactcgggag actgaggcag 81540
gagaatcgct tgaacctggg aggtggaggt tgcggcgagc cgagatcgcg ccaccgcact 81600
ccagcctggg caacaagagc gaaactccgt ctcaaaaaaa aaagaggaaa gaggaatctt 81660
ccccagtatg gcaggcaatc tttcctgcct caaggagatc aatttacatg tcacctggaa 81720
gcccataata ttctgcttta gcagtgactc cttgtgattg gatgtttcct atggccaatt 81780
gtgcctgtgc ttcatgccct acttaaaatc aggacatctg ctctgccctt ttggaagagc 81840
tacaagtctc ctgccaggaa ttgctcaagg ccttttcctg cagctaaacg gagaaaggaa 81900
gttgaaatca ttgcctcata aattacaaca catgccaggg ttgtaaccta gagtctgagg 81960
ttctaggcga aaagaggatt ttgtgtgtgt gtctagtgtt ttccccacag catttaaaag 82020
ctcatctaaa atatattata attgcatgag atatggcaaa aatacattca gaaactaatt 82080
ttttgaagat aaacaaacaa agcagaatgt gcccataata ttcctaagta aagccacaca 82140
aacttccttt ccagtaaggg tatcctttgg ggctttttcc ccctccttgt caccaactta 82200
tcttgaattt atcactatgc tttttcacta ttgttcctaa acttcagctg ttatataatg 82260
agatagtggg catttagtct tatatccaaa tttccatatt tcagctttta aaatagttgc 82320
aaggatgctt ttaaagttga tcctggccag gagaggtggc tcactcctgt aatcccaact 82380
ctttgggagg ccaagatggg aggattgctt gagtccagga gtttgagacc agcctgggta 82440
acaatgagac cttgtctctg caaaaaaata aaaattaact gggtgtgatg gcatgcactt 82500
gtagtgccag ctacttggga agctgaggtg ggaggattgc ttgagcccag tagataaatg 82560
ttgcagtaag ccaagatcat gccagtacac tccagcctag attagagagt gaaactctgt 82620
ctcagaaatt aaattaaatt aaattaaaaa gttgatccta gcaaactaac accggaacag 82680
aaaacccaac accgcatgtt ctcactcata agtgggagtt gaacaatgag aacacatggt 82740
cacagagagg ggaacatcgc acaccgaggc ctgttggggg ttgggggcaa ggggagggag 82800
agcattagga caaatactta atgcatgtgg ggcttaaaac ctagatgatg ggttgatagg 82860
tgcagcaaac caccatggca catgtataac tatgtaacaa acctgcacat tctgcctatg 82920
tatcccagaa cttaaagtaa aataaaaaaa gaaagaaaaa aaaagttgat ccttaggcct 82980
gtttatagtc caagggagct gtgaatgctg aaatttgtac actgtcaatt tatatgtata 83040
ttcacatatt aatatctata gtacacatag attcaggaat gtagactttt gtcaaatggc 83100
ctagtagata ctgataaaac aacttctaat attaaattaa aattttattc tattttaaag 83160
aaaaagaaca aataagaaaa tcgtctttgc aatgaaaagg tcagaaacca aggatgtggt 83220
gtcctaatat gctgatagca gagattatat ctcctttgcc ttcctatcac tggttcttaa 83280
taccttggca agttagtatt taggaattgt tgaattaatg tttggcacat gaagatcatt 83340
aaagcaataa ctcataaagc atggggaaaa caaggtcatt tgctaaaggg gaatttgggg 83400
gcacgatatt tagcaagtct tctttcacac ttatagctaa atattttgtt tatttgatta 83460
tttgattgat ttgggtgtaa attctattgc acctctggta aaccaagtca gcctgccctt 83520
cctggttaag aaagagagac agaaatgcaa agtgtaacca gcttattaat aagccgagga 83580
tagagaaaag aaatttgtct ctgggctggg agcagtggct catgcctgta atcctagcac 83640
tttgtgaggc cgaggcaggc gggtcacttg agcccaggag tttgagatca gcctgttcaa 83700
catggtgaaa ccccatctct actaaaatta caaatattag gcaaggatgg tggcatgtgc 83760
ctgtaatccc agctacttgg ggtggctgag acacgagaat cgcttgaacc cgggaggtgg 83820
aggttgcagt gagctgagat cgcctcactg cactccagcc tggctgcact ctagcctggg 83880
caacagagtg agactttgtc taaaaaaaaa caaaaaacaa ctgtctctgg cataacttga 83940
gaagggagaa gctagaagag acctttggtt tcatcaggtc caagcactgc taaccattca 84000
gctattctgt gggcagaatg tctttgttct tccaggtgca acttcagcag ctgtgggcct 84060
gaactgacag tgcggggtaa ggatatcact ctctccatgt gaaacaaagc aggactacag 84120
gaaagcaggc tgatttggaa aggccaggcc cacccaggac aagaggcagt gctgagtgtt 84180
tggctcatga caaaacataa tttacaaatt tactggcttc aaggatgtaa aaagttataa 84240
tttactggct tcaagggtgt aaaaaggcct gcttcctagc ctagctgcaa gcagcaactc 84300
agtccatgat cagcagattt tctgaagcct gggggtggga tgcatgttgt taacctctga 84360
tgcagatgtc tgctgagagt ctgtaatctg tgtggtcatg aagatgagat ttcatccatc 84420
aattgcttga caagggctat catcgtatct ctgggcctgc gtggctctca acacacgacg 84480
taagaaacat attggacaaa agcatttcct gggagaattc tccagcaaga attcagccat 84540
tggcaaagaa tctttcaagt ggccctatct cactggagac aagtaaacat atacgcagtg 84600
catatgtgaa tatacactcc ttcaaggtgc tgcactttcc tagaaacaaa aagaatgaga 84660
ggaaaaagct ttacaggcat cctgttagga tgctttctct cgtttatttt taggctcttt 84720
tcagctctgt gctaagaggg gaggcaaagg aagggcttac ccagaatgca aagcttttta 84780
gtgagggttt ggggtgtgca aatttgttaa agtggtgaaa acccagtgtc tatggaagtt 84840
cacagcatcc acagcactca gagcccccca aatatctctg gcccttgtgt tcactaattc 84900
caaggaattc tcagccattc caggggactg tggggatccc cctgaaacca ctacaattac 84960
ccagaatgtg cccctcctaa cacataggca ttgaaccagt tcctaactct cccccaactc 85020
tcacagatct ctagtacttt aagagccata tggcacacat gcttagccct cagccttctg 85080
cctaataggg gagtgctttg ccagggaaaa ataagattag ggaagaggac aaagaaagaa 85140
gaagagaagg agtttccata tccattaatg aattcattca acagatggtt atggaacact 85200
taccattttc caaagaccgt actatggtgt gggttataga ataagaaaca gcctggcttt 85260
tgaggagtag aaactgtccg gtggaactaa cattaaaagg tggtaatata acatgacaat 85320
tgtactgatg cacatagacc ctggggtgtt ttagggacat agaggatggc accaaaccta 85380
gactgagggc atcatccaga cagatacatg ctcttgtttc tgtgagtcct gtgaggtgag 85440
tcactcacaa agaaaatgta aagaaataac tcagaataaa taaaaagata gatggcacag 85500
taagcttggc agattgatgt tggagaacgt cagttttggt ggcaacaatc tgcaaggttg 85560
tctaattttc tcctgcacca ctcggctgcc cggatgcaaa agcagacaat ggattgtggc 85620
tctgatctga gttttattgg gcagatgctg cagaagggct tgtttgaaaa gggaatagga 85680
tgttattgag agaacagttc agatgaccaa ccagggatct gaaattaggt agagacagta 85740
agagagactg ataaactatg aggaagcaaa agaaccaagt gactggaggt ctataggctg 85800
tcaatgtaca aatgtggcag gagtaagcac atgagagggc tggaggatag gatgctcact 85860
catttattcc tcagatgttt attgagtgcc ttcagtgtcc aggtagtgtt ctagttctga 85920
gagtacatca tgcacaatgc tattgggagg agaaaacaat aaataaaatc ataataataa 85980
acaagtaaat tatgtaatat gttaaaaggt aataagtact atggttggat gggggcaggg 86040
gaagagaata gagcagaata agaattcaga attccgagga tagggtataa ttttaaatag 86100
ggttgtcatc atagctctgg ttgagaaggt aacatatgaa cacacaatca ggagagaaag 86160
aggatgagct atgcagatac atgtattgaa atattccagg cagagagaac agccacttca 86220
aagcctcgca gtgtgtgagt gcctggtgtt ttcaaggaaa agcaaggagg ctgtgtggct 86280
ggagtggagt gggcctggag aagatgtaag aaatgaggtc aagaaacaac agggatcgag 86340
tgtgtaggct ttgtagactc tggtaaagac tggctttccc tctgggaaat agagagtcat 86400
tgtggggttt tgagcacaga agtgatgtga tcttatgtct ctttaatgga ttactctagc 86460
tgctatgttg aaaatagact tgagggaagt gccagggtag aagcagggag accagttagg 86520
aggctattgc aataatccaa ataagaaatg caaagtaaga ctttgatcag gtggtggcag 86580
cagaggtggt gagaaggagt tagattctgg atgtatttcg aggatagagc caacaagatt 86640
tatgacagat tggatgtggg tagtgagcaa gagtcaggat gactccaagg tttttggtcc 86700
aggcaaattg aaaggtggag ttgccattat ctgaaatggg gaagaaggtg agcaattgag 86760
agggagactt ggagttaaat tttgaacaga ttgtagtcaa attggtgttg ggatattggt 86820
gtttacaatt cctgaagggg aaccattctg agtgacccta agacccagag tgtaacctgg 86880
ggatgggtgt ctgaagagga ataaagtgaa atcattatga ttgaataatt tagaactctg 86940
gaggctgaaa agctaatgaa atctcctagg atgttctacg aggatggtgg cccaggcacg 87000
agagtaggga acggggtcag gccttatgat ggatacttta aatacaaata gttagaggtc 87060
acactaatat tagcttgagg tgtgcagaat tttaattggg tgcagattag tgtatacatt 87120
agaaataagc aagatattaa aagatcaaat ttgctgaaac acatcagata acattatgat 87180
aaaggtattt ggagttttat ttgagttaga tttacaatcc cattgtagca tggatcaaaa 87240
acagtaagtt gataaagaaa tcagataaat tttcacaatt taaattttaa ttgttttatt 87300
aaaaagcatt ttggaaagac attcatattt ggttttggat aggttaaagc tcagtgatac 87360
catttacatc aatttttata gcattttaga gagcatggtc ttgtgacatc ttaggataag 87420
ttttctgtta gtcacagcat gccaacaagt accttgtgct ccattctctg gccatgtttt 87480
cagactcagt aacttcaaat aaaataaact gccaagttga gaaattaaca tttgataaag 87540
tttttgcaac atcataccat tgagctggtg gatgtggctt aagcatctga attcattaga 87600
gactattgaa atgataatgc agaattatac aggttttgca gatgtagttc aatatttatc 87660
tatatgtatt gaaacctcac ttgaggatag aaaaatcaag caagttcttg tcttacattt 87720
ccactcaata aatgaagagg aagagataat gagaaagcta tataatcctt taaaaaaaaa 87780
attcaccttg tttctgactg acagtaaccc aattcaggct ttttactctt cataaatgga 87840
agacaagtaa cctagatagt actggctatc tataattaaa tatacaatat tgaaatctat 87900
ttgctttgtg gaaattatgt gtttgtggct gattaaaata ttcagctatg taggcttcat 87960
cttttagctc aatagaaaaa tataaatgac attggtgact gaattcctac caacgtggca 88020
aagacattcc ccagacatac ataattcacc tgctgaattg gagatgattc acctttcagt 88080
gacttcacag gtgttaactt ggccaaacaa aaaagggaaa tcatcttgta ttcatctttt 88140
gttccctgag gcaagttttc agtaagattg ctcgggaaaa atatcacaat atacatatat 88200
aagtccatag tatgtctatt tgaataatga attagcacca ctgtctgaga ggtgaaaact 88260
attcaatgta tattttctgg aaaataacta aattgagttc ctcttaacta aatcagaaag 88320
agaaggaatc ctcaatcagg atttcatgta gtactgtatc actcaaagga aaactgattg 88380
tatagtggta ctcaaataaa gtgggtccaa agaaaaatta tgagagaaac gtaccgatca 88440
gtgatctgga ccaaacagac atgtggctgt gaaatccagg cagttgcttg gtgacgaggt 88500
caccatcaga tagtcatggc ttatgtgcag gaatgtgaga atggccatgg ggaggaatgg 88560
cctgggttat gggtcttgca ggagtcccac tgcttgtgcc attgctcaaa cttctgactg 88620
ccctgtgcag ccggtgccag gtcagcagta ctctctgctc tgaatcagtg tcagcactgg 88680
tctctctaat gtagtacctt tcttcaaaaa atgctttgtg aagctgctgg ttagcactgt 88740
tcttacttct gtagttaata ttcaccacat attccccttc ttttgtggag agataaagaa 88800
attaaggaaa atcactctcc ataagtccac aatctgaaga catggaggct gaggaggcag 88860
acctgaatga ataagtggat catatgatag ggctagatct taaatttgga tacaggagac 88920
ttaaggtaaa ccacagaagc ttgttgttta tacatgtagc tcttttgcta aatataaatg 88980
tggcatgtga agattaataa atctgaatgt aatgtacaga atgtactaga acaggaaaaa 89040
attggtgttt actgagagct gaaggttaca tcaaaaatct aaaaagtaat atttttgcat 89100
catcttaaag tttgcaaaca gttttggcac atacatcatc tcatctttgc aataacctgt 89160
ggggtagata caaaagatga tgttattttc attttccaga tgaggaaata ggagcctgtt 89220
tcctggtcag acaggcttag tcagctgtga gtggcagagc tggtgttccc acctgttacc 89280
ctcaacccca gttccattgc tcctaacatg attgtatcct ggataaacat ggtatcaaga 89340
atggagaggc caagcgcggt ggctcacacc ggttatccca acactgtggg aggccgaggt 89400
gggcggatca cctgaggtca ggagttcgag accagcctgg ccaacatggt gaaaccccat 89460
ctctactaaa aatgcaaaaa ttagatgggt gtggtggtgc gtgcctgtaa acccagctac 89520
tggggagact gaggcatgag aatcacttga acctaggagg tggaggttgc agtgagccga 89580
gattgcccca ctgcactcca tcctgcacaa tagaacaaga cactgtctca aaaaaaaaaa 89640
aaaaatggag agtgaaattt gggaggctga ggcaggcaga tcacttgagg tcaggagttt 89700
gagaccagcc tggccatcat ggcaaaagcc tctctctact aaaaatacaa aaatcagcct 89760
ggcgtggtgg tgggcacctg taatcccagc tgctcggggc tgaagcagaa gaattgcttg 89820
aacctaggag gcagaggttg cagtgagcca agatcatacc actacactcc aacctgagca 89880
acagagagag actctgtctc aaaaaaaaaa aaggatggag agtgagagaa aactcagaga 89940
ctttgaaata agaagtgaaa gaggccgggc acagtggctc acacctgtaa tcccagcacc 90000
ttgggagacc gaggcaggca gatcatttga ggtcaggagt gcgagaccag cctggccaac 90060
atggtgaaac ctgtctctac taaaaacaca aaaattagct gggcatggtg gcgggcacct 90120
gtaatcccag ctactcggga ggctgaggca ggagaatcac ttgaaccagg gaggcagagg 90180
ttgtggtgag ccaagatcat gccattgcac ttcagcctgg gtgacagagc aagactctgt 90240
ctcaaaaaaa ttaaaaaaag aagaagaaat gaaagaaact tggcaattga ttgggtgttt 90300
ctgataaaga aacagaagaa ggaaaaggtg attcctaggt ttctaaaacc tggaagaggt 90360
ggacagtgag attataatat aagcagctga tgttggcaac atgcctacta tgtgccaggc 90420
catgtgccaa gcattttgcc atattgcctt attaaatcct tacaactctt tgaaggtaga 90480
tcgcataatt attattctca ttttagaaaa gggtgtgcat gaaagttgct ctcactttta 90540
gaaaaagaaa aaaatcttcc ctccaaaaca aggctaagct caactggatt cactggccta 90600
tgctgacagt acctggggcc tgggacagtg gtttggtgtt cttgtgtgta tggatgtatt 90660
acaatgtcag acacaaagta actaagccgt gctcctggcg gttatgatgc ttgcaaatcc 90720
agcactgcca aactgtttag tgcctcctag gtgctttgcc tgtggttaga acaagcttca 90780
ctaagtggat agttttgcct tggccctgcc tttaaggcag tctgccatgt catcaagaga 90840
cataggtaag aatgctctcc tccttagtta tgatttaaaa ataaaagtat aacaaagtat 90900
aattatcaaa tgactattag tagaaatgtt gcatttatat acactattta gattacaatt 90960
cttaaataca atgtctttcc ttcttgttac ttgtaattaa ttagtatcag tcactgtcca 91020
gtgtgagcct ggcattgccc ttaggttaac cagttcacat cctgaacttc tgttggtgcc 91080
cagggtattt gtctgaaacc ctgattattt acatctccct ctaactttca aatttgtctc 91140
caatctcatc taaaactatt aatacttgag aaaaggcctt tccccaattt cctgcttcta 91200
atccctttat cctctttctt tcttggaaaa gtagaggaaa atggtttaca tatcaaataa 91260
agtaaatagt atatgaaaaa aaaaaaacct ctaagggctc caaactctgt ggatatctac 91320
ctgctggtta tttattcact aagctgcaca tagcaatccc ctagcaacca taaacttcat 91380
gcataaaatc ccaactcttc tccaatacca cctgtttgta ggtagtcatc cttcttttaa 91440
aagacttggg agttatacaa ggaataagtg ccagagttta gttctttgtg aaaataaatt 91500
taaagaaatt ataagttttc acagggctgt aaagatgttt cttcccagtg gtccttcact 91560
ccaaggctgc actggagatt atgctggtga ggaagctttg gtctcgtagg tctttggccc 91620
caaggcaaaa ggtcatggct gtaagtgtct ttcttcctga tcccctctag gattgtgaag 91680
atgtccagtc ccaatctgaa cattgtgacc ttactgggca gttgtctcac ttacagtagc 91740
gcttacctct ttgggattca ggatgtttta gtggggagct caatggaaac tctcattcag 91800
gtaggtgaag ttttaaaatt tggttttgac tataaagttt tgattatttt tttaaaccag 91860
ctgctcccgt gggtggtggt ttcctttatc cttggagtgg gcacttttcg agggaatccc 91920
agaacacttg gtgaggttca ctctgtacct cgtgcgctct gtgggaccca gaccctacag 91980
atcagagtgt gtggagaact gataaaggtt cctcttgtga ctcttctgtc cccttccacc 92040
catagacaag actgtccatg ctgtgcattg ggacctccct tgtgtttggc cccattctgg 92100
gaaagagctg gcgactctac aaggtgttta cccaaagggt cccggacaag agagtggtga 92160
gtaggcagca agtacacaat gcttgactgt agatggtagc ttcagcattg gttaacagct 92220
agagaagctc atgcacatta ctgagcctag cccctttcag gacatccaaa gttcctgttt 92280
ctcattccaa accctggaat catgcagcct cataaggcct caggtctgga aggctgtgga 92340
tcagtgctgt tgaagatagg gcttcaaacg tgggctctgg ttcctatgta ccccaggccc 92400
tgtggggaca tgtgagctgg ccaatacctg gcaccagtgt gaggcagaac aagataccca 92460
gagactgttg tttggcacag gtgcgagctg gaagtgaagg gaggaagagt gattacagag 92520
aaactatagc aagtaagtag ttatttcctt ccctggagtc cagttctttt ctatgtagaa 92580
ggcagttctc tgtactgaga aggatgtgcc caaagcagtg agcaaggaag agcagataga 92640
atcaactcta agttatgtag cagccagatc accgacatgt ccctggtatc agtcatcaac 92700
ttaaccacat ttccccattt tatcaggttg tctgatgaga ctgctcaaac ctcaattcct 92760
gaccattatc ctcattgggt ataggccctg cccagaccca atatatcatt cagttggtgt 92820
ttacttctct ggaatgatgg gaatttattt tagcaaatgt tattgaatca tggtgcatac 92880
ttaccaaaag ctcagctgtg agcaaccata cctatgaaga agattgccta aaaggacaaa 92940
aactgcattc atccctcaag aacaccaatt tcttttttaa acagctttac tgaagtataa 93000
ctgacatgca gtgaactgca catatttaaa gcatatgatt tgataaattg tgacatggat 93060
atacaaccaa gaaacatggt gcataatgaa catatccctc atcttcaaaa gcttccttgc 93120
aaccctttgt tatctccctc ccctgtccaa tccttatatc ccttgttcct atcctcagaa 93180
aatcattgat ttgctgtcac tgtagatgag tttgcatttt ccagagtttt acataaatgg 93240
aaccatgcag tatggactct gttttctctg gcttatttta ctcacataat tgtttttatg 93300
aatattatag ttatttatct atgttgtgtg catcaatagt tatttctttg ttattgctga 93360
gtagtattac aatgcataga cacaatttgc ttatctgtag atggatgttt gggttatcgc 93420
cagttgtggc gattaaaatt aaagctgcta tgaacattcg tgtacaaagt ctttgtttag 93480
acataggctt ttatttctct tgggtgaaaa cctaagagta tggttggatc atatggtaag 93540
tgtatattta actttttaag taacagtcag actgtttttc gaagtggttg taccattctg 93600
catttccacc agcaatgtat gagagtccat ttcctccaca ttcttggcaa catttgattt 93660
gatcagtctt tttcatttta ggcattctaa taggtatgtg tggtagtatc tcattatgct 93720
ttcaaatttg catttctcta atgcagtatt gagcatttct tcacttgctt atttgccatc 93780
catacacctt ctttggcaaa ctttctgttc aaatcttcca cccatttttt ttttttttct 93840
gagacagagt ttcattcttt cgcccaggcc ggagtgcagt ggtgtgatct tggctcactg 93900
caacctctgc cttctgcttt ccagcaattc tcctgcctca gcctcccaag tagctgggat 93960
tacaggcacc caccagcaca cccggctaat ttttgtattt ttagtagaga tggggtttca 94020
tcatgttgac caggctggtc tcgaactcct gacctcgtga tccgcctacc ttggcctccc 94080
aaagtgctgg gattataggc atgagccacc acacccagcc tcactcattt ttaaattgga 94140
ttttttgttg tcttattatt gagttttgtg agttcttttt atattctgga tacaaaccct 94200
ttatcagatg tatgatttgc aaagattttc ttccagtttg ttcttttgtt ccttttactt 94260
tcatttactt cagaatgtct ttcaaagata agacatttct cattctgatg aagttgaatt 94320
taccaatgtg ttctttgttt ttaggtttct tgtttatttg tttgtttgtt tttgtatttt 94380
tagtagagac ggggctttac catgttggcc aggctggtct caaactcctg gcctcaagtg 94440
attcaccagc ctcagcctcc caaagttcca ggattacagg catgagccac cacacccggc 94500
cccaatgtgt tcttttatgg atcatgtttt tggtattata tttaagaaat ttttgcctaa 94560
cttaaggccc caaaaggttt tctcatgtgt ttacttccag aaattttaga gttttagctt 94620
tgacatttag gcctatgatc ggtatatggt atgatgtatt gattgaattt tagtttttta 94680
catatagaca tttgattatt ccaacatcat ttgttgaaaa gattgtcctt tcttcactga 94740
attacctttg tgcctttgtt aaatcagttg tccataagtg tgtagatcta tttctggacc 94800
ctccattctg tctcactgat gtgtctatct caacagcaat gccatattac cctgattact 94860
gtagctttat actaaatctt gaaatcaggt agtattagtt ctttgacttt cttcttctct 94920
ttcaatgctg ttttggctaa tctgggtcct ttgaatgccc atgtgaattt ttgaatcagt 94980
tcactgattt ctacaaaaat tcttttggga ttatgttgaa tctaatagat caaattatgg 95040
agaattggct tcttactaat gttgtgtcct ttgacccatg aacccattta tttaggtctt 95100
taatttttcc catcattttt ttgtactttt caatattgct ctttcacatc tttcatcaaa 95160
cttatttcta gggattttat atttttatgc tattttatat gttactattt ttttaaattt 95220
cactttccag ttgtttgttg ctaataaata gaaatataat tattattatt attttttttt 95280
gagatggagt ctcactctgt cgcttaggct ggagtgcagt ggtgcgatct cggcttaccg 95340
caacctccgc ctcccgggtt caagcaattc tcctacctca gcctcccaag tagctaggat 95400
tacaggtgcc tgctaccaca cctggttagt ttttgtattt ttagtagaga tgaggtttta 95460
ccgttttggc caggttggtc tcaaactccc aacctcagat gatctgcctt ccttggcctc 95520
ccgaagttct gggattacag gcattagcca ccatgcctgg ccacagaaat ataattaatt 95580
tttatatgct tagcttgtat actgcaacct tgctaaacta catgttagtt ctagcagctt 95640
ttttatagag tctatcagat tttctacaaa gatgatcata tcagcagtga ataaagataa 95700
tttatttcca atctcttgtc tgattgcact ggctagatac aatagtacaa tctgaataga 95760
agtggtgaga gcagatatat ttgttattct tgatcctatg gggaaaacag tcaaaactaa 95820
gaatgatatt agcagtagtt ttattgtaaa ttccatttat ccagttgggg cagtactatt 95880
ctattcttat tttgctgaga gttttaatca agaactgatg ttgggttttg tcaaaagctt 95940
tttctgggtc tattgagatg atcatacagt ttttcttttc ttagtttatt cgcatggtgg 96000
attatgttaa atggtttttt ttttaaaccc ttacacaata gactttattt tttagagtag 96060
ttttaagtta acataaaaat tgagcagaag gtacagaggt tttacatata cagtctttcc 96120
ccacacatgc atagcctctc ccattatcaa tattccccat cagagtatat acttattaca 96180
attgatggaa ctacattaat acgtcattat cacccagagt ctgtacttga cattagggtt 96240
cacttttggt gttgtacatt ttatgggtct ggacaaatgt gcaatgacat gtatctacca 96300
ttacagtatc atacagagta gttttactgc cctaaaaatc ctctatgctt ctgctcatta 96360
tctctttctc tccccatatg ttaaatgatt tagggtgtca aaccaacctt ccatccctgg 96420
gattagcttc atttggtcat gctacattat cctcttcata tattgttgga ctcagtttta 96480
taaaaacttt gtttagaatt tgtacattca tgtttttaat acatattgct ctgtggttgc 96540
cttgtaatat atttttctag ttttggtatc agggtaatgt tggctttata aaatgagttg 96600
ggaactattc ccttcttttc aatttcagga ataatttcta tagaatagca taattggcac 96660
tcatgtataa gtaccttaca atagtatgct tccttttatc cccattccta tctttgctgt 96720
tacatgttat aggccccatg caattctttt gtttaataaa tcaattatct ttaaaaatat 96780
tttatttttt tatttttaag acccaggaca acatgctgaa ttttgttatt ttctttaatg 96840
atatttaaat aatgaaaact aatcatgtat ttttctgttt agttaccatt tccagtgttc 96900
ttaatttcct gtatagatcc acatttttat ctcatattat tttcctttgc ctgaaggata 96960
tctaacattc cagtgtgggt gtgctactac tgaattcttt cagcttttga ttatctgaaa 97020
aagtctttat tttgccttca tttctgaaag atatattact gagtatagaa ttctagactg 97080
aaattttctt ttcttcttct agtactttca agatgttcct gcactgtctt ctcacttggc 97140
cttgtatctg atgagaagtg tcaggtttat tttatgtcta cacaaaatgt gtctttcttc 97200
actgcttgct ttgagtagtt tccctttatc actggttttg aacagtttga ttaggcaatt 97260
ggtttgtttt taattttaca aacaccttga atcacgtaac tggttgtgct tcttttcact 97320
ggttgtcaaa agctcagatc cacatttctt ctgctccaat tagtaaatgc tattatatat 97380
acactcttca tctgagcctt catcataatt ccctttattt tctctcttcc cggttgttaa 97440
atattttaat cctatcacag tatatatttt tctcaatttt atttttgtag tcacaaacta 97500
acacattctc ttcatcctaa gtcaaatacg gatggtccct gacataaaac agttcaactt 97560
acagtttttc tattttacaa tggtgtgaaa gcaatccaca ttcagtagaa accatactta 97620
aaatacccat acaaccactc tgtttttcac tttcagcaca gtagtcaata cattttatga 97680
gatattcaac acttcattat aaattaaatt aagctttgtt ttagatgatt ttgcccaggt 97740
gtaggctaat ataagtgttc tgagcacatt aaaggtaggc taggttaagc tgcaatgttt 97800
ggtagcctag gtgtattaaa tgcatttttg acttatgata ttttcaactt atgatgggtt 97860
tatccggaca taaccccatc ataagtcaag atcataagtc aatctgtaat tcatatgtat 97920
ataatgaaaa tgctaatgat tcttcctgca tctctgagtc ccaccctctc agttaatagt 97980
tattaacatt gtggtgtgac attcatatct atgtgcttat ataaacatat agaaataata 98040
gtttatttat tttataaaac accttgagtc ctttgtggga aaaggtagga tatgaagaag 98100
ttaaacaaat ggaaatgtgt aatgctaata atgatatcag catagaagtc attgtaaatg 98160
tttggtgtct gtttcatttt tgatagctac atttgaagct ccttgggagg gctgaccttg 98220
gagcatatag ctgagagcac atgggatact ctagcccctc tgtcatttag ccagtcaaca 98280
aggagaagtt ttgaccttga ctcttttgca gattatcaaa gacctgcagt tgctggggtt 98340
ggtggcagcc ctgttgatgg ctgatgtgat cctgctcatg acgtgggtgc tgactgatcc 98400
catccagtgc ctccagattc tcagtgtgag gggccaaatc cctagagaat ctcatcccca 98460
aactggactg acctctgtgg atacacagga gtcatccttg caacaagaag ataaaggact 98520
ccaagaggag ggagagtcag gagttgtggc ttccatgtaa ttcttgccct agtctgctgc 98580
cactcccact gctcctcctg cccgagtgtc tctttgtggg catacaatga gatatcagca 98640
tgctggaatc tgcctggcag ttctgccact tccacattat caataattaa aactttcagc 98700
tatcggcagt taccttcccc taattgtaga ggtggaggta gtagtttaag gtggcctttg 98760
gagtcagtca accctggttc aaatcccagc tctaccaagc tcaccagttg tgtgaccttg 98820
ggaaagttat gtaacctctc taagtctgtt tcctaattgg taaaattgag ataataatac 98880
tacctatctc atagggttgt ggcaaagatt aaatgaaaca atgtaggtaa aagacttaac 98940
catgtccagt acatactatt caattaacaa gaagtatggc cgggcacggt ggctcacgcc 99000
tgtaatccca gcattttggg aggctgaggc aggtagctca cttgaggtga ggagtttgag 99060
accagcctgg ccaacatgat gaaaccatgt ctctaccaaa aatacaaaaa ttagccaggc 99120
gtggtggcac atgcctgtaa tcccagctac ttgggaagct gaggcaggag aatctcttga 99180
acccaggaag cagaggttgc agtgagctga gattgcacca ctgcactcca gcctgggtga 99240
cagagtgaga ccctgccaaa aaaaaaaaaa aattattata tatctccagc ctcacgaggg 99300
gctgaggaat acagtggaat catggaatcg tgacactgca agattaatgt ttaaggattc 99360
aatgatttgc aaaaagcagg tgcataatga aatagtttat agttttgttg aggcactaat 99420
ttgattgggg tagcaaagca cataaatgag gggtaagccc tagtgtcacc aagcacacag 99480
ctgttagccc aactttatca tctcttctcc taacacgtag tcactctcat ttaggttcta 99540
gtggagtcac ctaaatgctg cagtttttac atactgaggg ggtatcatgt actctagaag 99600
aattcatgct ccagcatgtt cacaaagatc tgctttgtgt tcctggtaat tgtgggcacc 99660
tccagttctg actctgtgtc ccttctaggt gacagggaaa gacgtgtcct gcacttcgac 99720
cagcacccac ttctgtgctt cccggtattc cgatgtttgg attgctctca tttggggatg 99780
caaggttggt aaccacatct gatatggtct ctgtcaccaa gaaaatggat atgaagaggg 99840
aattacagga attaacgagg tgatgtctgc aaagaatctt gaactcagag gagacctctg 99900
ttgatgcata aacttcaaag ccatgactgt ttttactttt ctatttgtat ttgtttgggg 99960
gagaccctcc aactctttag actccctcat tcagtcctcc cccaaatcat ctggaattca 100020
cccactgttt ctcctattta ttggtctggt ttcttaattg atttgacaat accagttttc 100080
ccttcatctt ccctgcaaga ggaattatga ggagaaattt gacccagctt tatttgttct 100140
cctaagtgcc cttattatgt ctcttgtgtt ttcttcaaga tttgggcgaa ggtgtcctgg 100200
tgcctttcac ccacctgact ttctccctct ggttggaagc aagactggct ctgagacaga 100260
tggcagcatt cacagggccc tttgaggggt tccacctgtc tcacagtgtc tcccatactg 100320
ccccaaatct ctcaccatta gactcatttg tctctgttag atgggcaaaa gtagaatatt 100380
atttccagaa ggtagaggat acctgcatgg agcactgagg atggtcctca gaacaggaca 100440
gctggttttc agcttaggga gacagagaac tggtgctgag gggtacaggg cagtcctgat 100500
tccataaaca agcaagtcct gcctgacagc agactacctg ttgactatca gggcagagag 100560
ttctggttga ctgattactg gcagaggaaa aggaggagtt tttgtagaaa taagtaccct 100620
ttaagggtaa actctggccg ggcacagtgg ctcacacctg taatcccagc actttgggag 100680
gctgaggtgg gtggatcact taaggtcagg agttcgagac cagcctggcc aaacatggtg 100740
aaactctgcc tctactaaaa atatagaaat tagctgggtg tggtggtatg cacctataat 100800
cccagctact tgggaggctt gaggcaggag aatcacttga acctgggagg cagaggttac 100860
agtgagccaa gattgcgcca ctgcactcca tcctgggcaa cagagcgaga ctctatctca 100920
ataaaaaaaa aaaggggggg taaactttac ccacttcacc actaagaaag tattagaagt 100980
tgttgcttgt gaggaacagg tttaggggta ggccagacta gggcagggaa acattccttt 101040
ttaactatgt gcaaatatta ctttgacaga aatatttttt aaaagaagac tctaggaagt 101100
gaacagctct tgatctccag aatcttgcta atggttaaaa aaggagcttt agttgtgaca 101160
gatcagggtt tgaatctgac tccgcccctg gctagccaac cctgagcctc atttaacctc 101220
tctgagcctc agtttccaaa ttttaaaatg cggatgatga taatatcccc tcagaactgt 101280
tctgtctcta aagagttaat gcatgttaag agttttcagc cgctcctggt ccatagcaag 101340
agctcaataa atgttagata ttattattac tattcttcca ctgcccccta gacacttctg 101400
gaaaatacat tgcctctgtt ggttccttga gtccctgtag aagagtgtgt cctccctagc 101460
ccagaaagcc agcacttccc ccatagctac ttactttgtg actcaatttg atttattttc 101520
tccattgcct tttatatact ctcatttcca ttctatttta ctgtaatatc tttctgtagg 101580
aaaaagaagg aaaaggatgg agcatcagga aacttactga gccagacccc atagactccc 101640
tggtcagtga gaagctcctc aggaggaccc caatctccac attgagtcct aggacccctg 101700
ctctctgtca actgccccct accccacact tctcagcagt taaggccagt gatatgcaag 101760
gatcaaatat gactcactca gacaccagcc aggaatgtat agacacttga ttcacaccca 101820
tttccccttt aacaagaatt ttaatggaat taaaaacttt tagtggaatc atatctgaac 101880
atttcaaaat cacagaatta atttcatttg ccttttatta aattagcaat gatccaactc 101940
tgctgaatac cacctgatgg cgtcagttac ccaaaagttg ggcttccctg gtctcctgac 102000
ttatgtgtcc tctagtcatt gaagatctca gggtggccac atttggcctt caggccccat 102060
ttgggacact gggcattagg ggaacctgga aggtatctct tccatgctga ctccttccct 102120
tctggcacag ccagttctcc aaaatatgtt ctttagtgtc acccatgaag gtggagttga 102180
ccacgtcata tgatttgagg gtcaccagca ggtgtcctgc tgatacctga ctttattttc 102240
attattagtt ctccctctga atcccacagt cccaccccca cctcgtctcc catggcatct 102300
tcacgttctg agtcatcaac atgaacattt ttaggctggg cgcagtggct catgccggta 102360
atcccagcac tttgggaggc taaggcggtt ggatcacctg aggtcaggag tttgagacca 102420
gcctgaccaa catggtgaaa ccccatctct actaaaaata caaaattagc tcagcatggt 102480
ggcacaagcc tgtaatccca gctactcggg ggctgagaca ggagaatcgc ttgaacccgg 102540
gagacggagg ttgcagtgag cagagatcat gccattgcac ttcagcctgg gcaacaagag 102600
cgaaactcca tctcaaaaaa aaaaaaaaag aagatttttg tgcttacctt aaatctacct 102660
accagaccaa gtgttaaaag ccaggaccat gacttctttg tgtcactatt ttctgcccta 102720
cacgtactat ggcactgcac acatagtcag aaaggtgaac ctaattgaat ctatgtgtta 102780
tgtattattg actaaagctt tgatttctgt atgaatgcag ctcctgtgga gggggcagca 102840
ctttaaggtg ctatgagtta ttttctcctt agtacaaatg acaactctga gagcaggttt 102900
atattcatag gaaagagaac agaatagggc cctgggttcc ttgtagggga gcaagaaatg 102960
tcacaaaaag ggtgagaact atagatggag ctttcgctgt ctgtgcctgc cccacagtct 103020
tgcctgggtc ccagcctgcc tttgttctcc ccttttttta cccttcatct cccataaaca 103080
ctcactggca tggagccgct gctagcctgt agagatcctt tgtgtaaatt ttttgaaggc 103140
ccatcccttc tagtcagatg cagtcttgca ggtgcaaggc ttggcaagca gatggtgcct 103200
ttgggcaaat tagagaaaag agccccttcc tatgggcact accctggctg tggcacatga 103260
cttgacaagc agatcagagg tcactttcag cttccctgtg caccctcagc tttgagcagg 103320
gcaacaccag acaatggctg tggtagcact cactatcaga ggttctgtgg gcccactgtc 103380
ctccaagtgc ccaacagctc tttctgtagg gatactaacc cacccacatg atcctgtcct 103440
atgccttgtc tcagaagagt cttatttaat ggctgacttg ctgacttctg ataaactaat 103500
tctcagcaaa ggagaggaaa ataacattta ttaagtatct agtaggtata aggggctgcc 103560
ctgagggttt tcttatgtga tatcttagta aatcctcata gcagtcctta aggtaggtat 103620
tattatccta attttacaga tgaggaaatt ggttgcaaac ctactgctca ttgacctctt 103680
gttccacttc tctgagcctc cgtcacctct tcacccccca gggtctgctc ctgctgtatg 103740
gtgcctacct ggctggcctg actggccatg tcagctcccc tcctgtgaat cagtccttaa 103800
ccatcatggt gggggtcaac ctccttgtac tggctgctgg gctgcttttt gtagtcacca 103860
gatacttgca ttcctggccc aacctggtct ttggactcac atctggaggg atctttgttt 103920
gtacaactac aatcaactgc ttcatcttca ttccccaggt atggattttg cagggctggt 103980
cctcttagtc actctagagt ttttcactga caaattgctc attttgtttt ctactgatac 104040
ctttccatgc cacttattgg agagtcagaa agcagacagg ggatcctagt gagctggttg 104100
cctttgtcct ttctcactgt cctggtcagc aagggggaca aggcagagtg gtccaagcag 104160
tggtggcagc ccctgtttgc actcttccac acctgtggtg cctgtccctt gggggggctg 104220
cctcgcagtc ctgcttttcc atccaccctc tggtctgctg cactcgttcc ccatcctccc 104280
ctcatttcca tcatgttatt actatttctt tcactagcct gggagcaagg aacctttata 104340
tttttccaat tggggattgc agactcacag gaaaaaatcc atttagatgg aactttatga 104400
tttaaagtgc tttctctttc tttttattgg aggaaaatac agaacatttc tctgcttttt 104460
acaataagga gaggtagaaa ctaaataaaa atatgtttca tattatgggg attttaaaaa 104520
atcaaatgag ggaggaagac agaagcagaa atagccagat agcaaagaag aaaggtagtc 104580
agagggaaca gagaaggaat cctaggctca gaaagcaagg ggatgtggga ttgttcatgc 104640
tacaccctgg ggaccatcaa gccacatata tctaggttaa tgaacttggc actaggtact 104700
ttcttgtttc cctcctagtt ctccttttct tccctctgag acctccctca tcccactcct 104760
ccttcaagac cctgtcctga ttcccattgc aacttccagt tgactgtaaa ctaattcctc 104820
atgatggagc taactgataa tgtaagtgtt ggctgatggc acgttacagt gtatttgtga 104880
aagggaagag tgcactttgg gtcatgatgg tatgacatgg gcatagccct gttacgattc 104940
ttctctatca caaatcctca ttacagtact caacagaata cataaatatg gaaaaatctg 105000
cagcagcagc actagaaacg atggatggct attgcctctg tgccagaaac tggaggaatt 105060
tttgccaaat cttaatgccg taaaaactgg aatgaaggaa gccatttaga gctgaggctt 105120
gtttgtctgg gatgaggcag aaatgggctc tgagaagcaa ggactgtttc tccctgggag 105180
accgggggcg ggggcggggt gggtgggcag gggtaagggt aggcaggtgc cttttgggaa 105240
gcccacccct taggccctgc agccaatatt gttggattgg tagcgatcaa caatgcagag 105300
aactggtgct gaagggtaca aggcagtcct gattccataa acaagcaagc cctgcctgac 105360
agcagcctac ctgttgactg tcagggcgga gaggcctggt tgactgatta ctggcagagg 105420
aaaaggagga gtttttgtag aaataagtac cctttaaggg taaactctgg ccaggcacag 105480
tggctcacac ctgtaatccc agcacttggt gaggctgagg taggcgtatc acttgaggtt 105540
aggagttcga gaccagcctg gccaacatgg tgaaactctg tctctactaa aaatatgaaa 105600
attagctggg catggtggtg cacgcctata atcccagcta ctcgggaggc tgaggcagga 105660
aaatcacttg aacccgggag gcagaggttg cagtgagccg agattgcgcc actgccctcc 105720
agcctgggca acagagctgc taaccccttt cttccttgct tgcctgcact atagagacag 105780
caacagctag actcttcttt tgccagcttc ccatagagat aggagtgcct atatgacacc 105840
attttgaaca ctagaggttt tctgagaagc ttctgagaaa gcttttgctt tcctgaaaaa 105900
ggttataagc atggctaaca tcaccctttt taccttcttc ctgccttgaa tgtatgtgat 105960
tcctagagct atggcagctc tcttgtgaac ataaggaaaa gactaagaga atatagttat 106020
aatactagga agatacagct ctttccatgt aagattataa attctggagg aaatgatcta 106080
tgaagggaat ctgcagttca caagaagagg actacaaatg tctaaagatt tagagaagct 106140
gccttcctct ggagtagaag tgtttagaag ataccggact tgtcaataga attcaaagga 106200
tattgtctct tctcaactaa agcaaactat catgaaaaaa agctaatctt aataaaatat 106260
tgaataagga ttaaaaatat ggtattaaat ttaaaatccc aatagaagca ttgactgggc 106320
aattagacac tacaaaatat tgaattagtg aattacttta aggaaacaga aaataaggaa 106380
acaaatgaga gactagataa gaaaatatgg aaaatggcca gatgcagtac ctcatgcctg 106440
taatcccagc attttgggag gccgatgtga gcggatcacc tgaggtcagg agttcgaaac 106500
cagcctgacc aacatggtga aaccccatct ctactaaaaa tacaaaaatt agctgggcgt 106560
tgtggcatcc atctgtaatc ccagctacta gggagactga ggcaggagaa tcgcctgaac 106620
ccaggaggca gaggttgcag tgagccaaga tcacgccatt gcactccagc ctgggcaaca 106680
agagcgaaaa tctgtctcaa aaaataaaat aaaaagaaaa aaataaaata tggaaaacat 106740
ctaggaatac aattgagagc tgataggagt ctctgaaaga gaacaaaata atttggggca 106800
gaagtcatta tcaaagagct atcagaggaa aatgtttctg aacaaacaaa gccttggtca 106860
gaaaactgaa tgaattggca atctccatga tggcgccctg cttactgctc ctctctccat 106920
cctcacctct caccactgcc cccttgcatc gtaagcctca gccacatcac ttcccctttg 106980
cctggtgttt gagtcctcag cagctaggac aattgtgaca tctgggtact ctacacacaa 107040
aaatgcagaa tgaagtgctg cttgaaatct gccttccagg ttttcactaa gcaacaaaca 107100
cttgatttgt tgaattggga atggaaatgg aatgattatg aggtacagga attgggtgga 107160
tggactgcac tggccttgct ttccttctat ctcactccct ctttccctcc tagctttctt 107220
aagcttcctt tctcttactc tgtctttcct cttccatttt ctcccttgtg tttttttttt 107280
ttctcctctg gaactaactg accatgatgt gaaactaaaa aatatatttt gtagtctgtt 107340
gtattttagg tttagatggt aagtagttct ttttcaaaat ataaaagaaa ctgaggtttg 107400
ttaggtttct gtgtgtttcc ctctggctcc gaggtctttg gtagaagaac gattctccct 107460
gtgatacttg cactgtgtat tcctagaaga taatttggga aagtaatttg agtaaatttg 107520
ggaaagtggg tgaggggaac tatctgggta agggttgggg gttgcagcaa aacggggttc 107580
cttcttgcca gtgagctttc agacatgact gtgatgggag gagtttgtga aagcaaaggc 107640
acagataccc ccagggcagc gaggcagcgc cagagagcgg gtgaaatgga tgacattact 107700
aaggagacaa ggggcccaag aagccttctt tacacaggca ctcaggaaat gcctgagtgt 107760
ttatgccaag cactgaggtc atcactagaa gtcagccagc cgctgctgtt ctgacctgaa 107820
tatgacccat cccccagccc tctgctccct cagagaggca ggcaggtcct aaggtaggac 107880
attgttttct ctctcctcta accccgaaag catttcatct gctcctccct gaagatgtgc 107940
aggcctttct aatctgcctt ataattatat gtatatgtcc cagcacccct actagaccag 108000
tgagcatttt aaagaaagct tccttcattt gttcatgcat gcatccatcc atccacttat 108060
taactgctgg gtacatgcac ttaaacacag agtccgcctc taggtctagt ggggagcaaa 108120
catgaaagga attatcatac atgtgttaag agctttgaga aaggccttcc ccagcccatc 108180
tgagaactca gtggcacctt ctcagaaaat gaggctgggc atggtggctc atgcttataa 108240
tcccagcact tttcaaggct gaggcgggta gatcgcttga gcccaagagt tcgagagcaa 108300
cctggtcaac atggtgaaac ctggtctctg caaaaaatgc aaaaattggc tagacgtggt 108360
ggctcacgcc tgtaattcca gcagtttggg aggacaaggc gggcagatca cgtgaagtca 108420
ggagtttgag accagcctgg ccaacatggt aaaaccccgt ctctactaaa aatacaaaaa 108480
attagctggg tgtggtggcg ggcgcctgta atccagctac ttgggaggct gaggcaggag 108540
agttgcttaa accgggagac aagggttgca gtgagccgag attgtgccat tgcactccag 108600
ccagagacag agtgagactg tctcaaaaaa tataaagcaa aaattagcca ggcatggtgg 108660
tgcatgcctc tggtcccagc tacccaggag gctgaagtag gaggatcacc tgagcccagg 108720
aggttgaggc tgcagtgagc tgtgattgtg ccactgcact ccagacagag taagaccctg 108780
tctcaaaaaa aaaaaaaaag aaggaaggaa gggagagagg gagggaggga aggagggagg 108840
taggaaggaa ggaaggaagg aagatgaggt gttcgagctc agtcttgaag gaaacataag 108900
agttcattga agagatgggg gaaagtaggt ggcatttctg atggaataac atcatgacca 108960
gaggcaggga ggctagaaag agagtagcgt atgtttggag caccatggtc tttgttattt 109020
ttgaagcaca aatggaaacc agggggagaa tgacaggact ggggagagac acacctgggg 109080
agcttctgag gccctgctgg accctgttaa agagttgaca tttagtccca ccatattagt 109140
ttcccactgc tgctataaca aattcccaca agcttagtgg cttaaaataa tacaagttta 109200
ttatcttaaa attttggagg tcagaaatct gaaataggtc ttatttggct aaacttaagg 109260
tgtcaggaag tctgtattcc ctccagagat gcaaggggag aatctgtttc cttgtctttt 109320
tcagcttcta gaggccgtct gcattcttgt gcttattgtc ccctcctcca ccttctaagc 109380
cagccaggtt caaatctgcc agaagagatt caaatctttc tctctctcgc ccctgtttcc 109440
attgtcacat ctccttctcc aactctggct ctcctccctc cctcctataa ggattcttgt 109500
gattacattg ggcccacttg gataacccag aataatcacc cctcttgaaa tccttaatta 109560
catttgcaaa gtcccttttg ccacataagg tcacatattc acaggctcca ggaattagga 109620
tgagagagaa catctttgag aagccactgt tcagtctgcc acacccccat agcccagagg 109680
ctcagaaaac cagaatctgc ctgtccttct ggaggaaggc agaggagagg ccctgaattg 109740
tgaaattcat agctggattc cagaaaccct gaagggttga gccttaagga gtatcttcac 109800
aaatgaggaa tgaagggcta gagtaatcaa ggggtatctt ggctccactt ggccaattta 109860
gagacaggaa gaccaaaagc cctgggaggg cccttacgcc agtgctgagc tgctcctctg 109920
ccagccctgc agagaggcct cagtctggga gtgctggggg agatgaagga aaagctgtac 109980
tgcagcactg ccagggtcag tgtgaggaga ataaccctag gaggtctgat tcatccaccc 110040
aaggccacag atgaccttgt gttgttggct ccagtagctc ccaagtagga tggtgagctg 110100
agagcatcct ttcgtgggga gggggccttc aagaagggca tctgagaggg gaggtaccag 110160
gcctgaccca acacaggtca cacagactcc tggtgcgatg atggactcat gatgagtcag 110220
cagaggaccc aagaggactt gggtgataat atcaatttca gtggcattga aattgatggc 110280
aggattcaga atcctatctg agatttacaa aatttggttt acactccatg gtcggagctt 110340
aacaaatgtt tgatggatga gtaaagaaat cccaggatcc ctttgaggct acccatagac 110400
actgcagcat catttctaga atcaaggtcc cagggtcccc agtgtccatc actaggacac 110460
ttagttatgg ggattcctga gaggaaaaca gaggccttcc ccactgtggc ttcctgcgtc 110520
actcacatta ctgtcattcg gtgggtcagc agtaccccac agactcaggc agaggctcct 110580
gtttctatgt tcagcttcat tcctgttaaa ctaaaccagc ccatgcttct gcagagtgtt 110640
cctcaagacc agtttctcct gaagagcttt ccctggactg ccaccgttaa cagtctctct 110700
cttcatcaac tgagtgagga cacagacatg gcacagtgtc ctgcttacag ctgttgttct 110760
gctgctaagt ggctgtgtaa gcttagacac aacactcctg agcctttcct agtttgtcaa 110820
agaaactggg tgatgagcta gagcatcctg atgtgactag ggggcttccc tcaaaggctc 110880
tctgagcctt gattattgac ttgggttaga agttcaccca aaggaactga attttcaata 110940
gcagcaagca cattgttact gaacaaatga aaaataatta aatagctgca tgcaacgaga 111000
aagtgtcatt tgaaacttat agtgttcagg ttgcttaacc ccaggatagc tcctaactct 111060
ggctttagaa tgtggtggta gaagatactt cagctctggt tttctttgac cagtttggca 111120
atgggtaggc agatgggcta aggctgttct attttatcta cctgtcctat tcttcctttg 111180
gaaatttgtg tttgttttta gggtgttttg ggtttttgtt tttttttttt aagattgggt 111240
ctcactctgc cacccaggct agagtacagt atcacaacaa tagctcacag tagcctgaaa 111300
ctcttgagct caagtgatcc tcccacttca gcctcctgag tagctgggat tataggagtg 111360
agccattgca cccagccctt tggcatttta aaaattatat aaccttaaca ttttgtataa 111420
ttacaaaagg taaggacctt ttgtcattac catctttgag ccctccagag caaagtacat 111480
tttaaggaga gaatagcttg cgcatgtgtg tatctatgat agtgtcattc cttggtgttt 111540
atgagaaaga gtgagagagt gtgtttctgg atgtgtaatt aaataaataa catgtgttct 111600
tttatctaac agctgaagca atggaaggca tttgaagagg aaaaccaaac aatcagacgc 111660
atggccaaat atttcagcac tcccaacaaa agcttccata cccagtatgg tgaggaggag 111720
aactgccacc cgaggggaga gaaaagctcc atggagaggc tcctcacaga agtaagctct 111780
gcccctgcct ggaagattcc ctgtaaagga tccaatcatg catcggtggc ccccaaggct 111840
cttattgctg atgttctctt ttcctctcat tctcccactt ctcttaacag caagcaaaac 111900
ctcaccattt ccaccgtgac acgcatctac ttcattcatt cagtggacag atgtataatg 111960
agtcactcct atgtgccagg cattgtgcca gtgaacaatg aacaaaagca tggttcctac 112020
cctcacagag ctcacagtct agtggaagaa atagagattc attcatcaag caaacatgta 112080
attatacatt gtcataagaa ttatgaaaga aaaatcagag tggtaagaca gaataatgtg 112140
tggtaagggc aagaaaacat aacttagacc agtcagaaaa gactcattga gctgagggct 112200
gaaggttaag tacaaattag ccaggcaaag agtacaggga aaagtattcc aagctgcggg 112260
aacagcattg taaaggccct gaaatgtggt ggacactagc ttccctgtga tacattttct 112320
ctcttttttt tttttttttt tttttttgag atgaggcctc actctgtttc ccaggctgga 112380
gtgcactggt accatcttgg ctcactgaaa cctccacctc ctaggttcaa gcaattctcc 112440
tgcctcagcc tcccaagtag ctgggactac aggcacccac caccatgctc agctaacttt 112500
tgtattttta gtagagacgg ggtttcacca tgttacccag gttagtctca aactcctgac 112560
ctcaagtgat ctacctgccc tggcctccca gggtgctggg atcacaggtg tgagccgccg 112620
cgcctggcct cattttctct ttttacatag agtagtgtct tcatgtccaa gatctcctgg 112680
ggtccttact gtctttccca ggtactggct acagatctca atcagcccat catcccagaa 112740
agtccaggca tgtctacaga tggagaaggg gactaaacaa gggcttctga atgtgattgt 112800
agcaccaagg gagaatgagg cagctccccc gggcttcttt cttctgtatt tgagccagag 112860
ttggcccctc tcccagactt gggcagtgtg atgcaggcat gaagaaagca cgtggaaagg 112920
tttgaaggct tcgttgactc aggaagaagg cacagggccc aggggagtta gtcagtattt 112980
tgacactaac tgaattacat tccatatttt ttcagtttag aacctatctc aggaggtgtt 113040
atttggaaaa ctgggctttt tttttaggac tgctgcctag gtattaatag tccctgatga 113100
gaggatagtg tggtggggac ctagaaaaca caacagatga agggactcag cacacccagg 113160
cacccaccgt tcatgcccct ctatggttct ggaccatttt tgtccatcag agtaacacct 113220
ctccatttct ttactattaa gtatttcaaa gccagatttc tttccacctg gcaagggagt 113280
aatattgcct ttgatactct gtgaagtctt caaataagca tttttttttc ctggctacac 113340
agaaggccag aaacttggct agaacagcca ggatagtttt cattcacagt cagctgatgc 113400
tggaacagcc aagtggactg actctttagc cttatggtaa tttgcaacgt gctgtttgta 113460
cttctgccat gctaccctgt ttcccacgca gggactcaat ctgctatatc caaaaagatg 113520
ctttgagtct gcagaggaag cccttcaatg ggcacaggtg cacaagtggt aagaagctgg 113580
cctccccagt gcacgctaca cctggaatct ctttcccaga acaggccaga gaacaagcgg 113640
ccagtcctag ggcccggtgg caggtgtcag gaggttccag catctgcatc cccagctcca 113700
gcattgcccg ttagagaaac atgagtatct ctcctggctc aacatatgta cagaccttga 113760
ctctggccca tggtgtgcag tgccttcctg tgcaggcccc actcccccac tcaggccttc 113820
ctcttacttt cccgtgatct gggcagcccc atcttctcac acttttccct cttgcctcta 113880
tagccagggg tccccccaga agctgtttcg gacagcatct atcacatcta tcactgactt 113940
ccctgtctaa gagaaggcca gcagacagaa ccttccacaa ggctgaagtg ctttcctcat 114000
acactctgca gccaagtaaa caaacctatt acttttgtta cctgaaccat agaaacaaga 114060
ggctaattcc atgtctcctt atggcctgcc ccctgtgaaa catgcaggtg gatgttttgc 114120
ttccctcaat atgccaaaaa taataattaa taagctcatt gaagtgcagc tgccgtggta 114180
ggtcagattt cagtctcata atggcagtgc ctcacaccac acctctaatt agtatgcagc 114240
catggtaaaa acagagtccc acttcttttt ctggaagaag gaaattttct gtttaggttg 114300
atgtttctaa atctgtcacc agccagcttc ttcccaactc catgtttata gtatctttct 114360
atactcaaag gagtttatag ataaggcaca aaaagacagc actcagattt cacccacggg 114420
agtagttgcc atctgccgat gggtccttcc taactctgtg aggctataga ggcctccaga 114480
agcccacatg agaatgtgca cgatgggctt caggaggaga ggctggtgga ggagggagtt 114540
gaggtccccc catgagatcc tcagagagat gcctggcaca gcccaggatc acaaacacct 114600
gagtgtttcc ctattgctca tccattctgc ccctgacaag tccttgagtc atctgcactc 114660
acccagcaac acccagacct caccactctg cgggcagagg gaagggaggg aggacaggca 114720
cacatgtgct cagctgaaag tctcttctac cttactcacc agtccctcac tggccctgga 114780
ctctcttctg atggtaaaag aagtatactc aaccagggtg aaactagcaa taccaactat 114840
cagaaaaatc accttcccaa ttctacaagg ggagcagtgc atctgcttgg agagttgcta 114900
gtcagaatat tggactattt tgcttaagct actgctccct taaaggatca tttctaggca 114960
actctcccat gtaaacctga gatgaaacca caggttcact ctataactag tagtcctagt 115020
tagctgttat ggacggtata actaggcaat ttgtattggt tatcctaaca cagggaacat 115080
ccttttgttt ctagggcata ataaatggag gtccaaatgc tcatgcccag ctcctaaaga 115140
tgatagtaac aaagaggtag cattttggtg ttcagacaag cactttctag aacatttgct 115200
tacattattg ccttcccaga accctcgacc ccatgtcatc tgccccaagt ccagacgttc 115260
cctgtgaata tctcctccct gctctgcctt tgaggatcag aagtttccag agatggacac 115320
acagtctgaa ctagagaatc agctgctgca ccacagaaag atgtctgggc tgcagtcgtt 115380
ccctgcaacc cactgccaac actcctactc ctacttcatg ccccacaatc tcgcagttag 115440
gacaggcaca cctctgcagc tctcacctgc cagccctctc cggcacaact tgtttaccag 115500
ctaacatcca gcgagtaggc aggtcagtag cagaactgcc ccaggctcct tcgtctcctg 115560
ggctccattc tagggctgct gaatcaagct agcaggggct taagcccaac agtcctttca 115620
tttctttgtg cttcttcaat agttctgatg cttgcactcc tttaggtgag tggttcccaa 115680
catttttggc accagggacc acttccgtgg aagacagttt ttccacagat agtggtgggg 115740
ggatggtttc gggatgaaac tgttccacct cagatcatca gacattagct tctcataagg 115800
agtgtgcagc ctagacccct cacatgtgca gttcacaata gggtttgcgc ttctgtgaga 115860
atctaatgtc tcagctgatc tgatggaagc tcaggtggta atgcttcctc acccaccgct 115920
cacctcctgc tgtgcggcct ggttcctaac agtccatgga ctagtactgg tccgtggccc 115980
aggagttggg gacccctgct ttaggtgaaa tcaacagctg atattgccac atggtagctt 116040
tggccactca ctcccagagg tccagcctag ggaggtgata acaccaacct gagattctct 116100
ttggcccctc tcagctccaa tcttatttga ttgtcacaga aatctccacc cttctccttg 116160
ttcttcccat tttctaggct gtttagtaag aggcaaaata cttgttctcc tacttcttca 116220
tcccctggag atatgcttca catttatcta aatttttgca aaagtgtgat aaactccaag 116280
tgggaccatt ccaaacatta ttcagctcat acctgcggag tggcctgacc ctctcagttc 116340
tgggaaaggt gagagggcgc tgcagtggcc agcaggcact cagactgggc ctccttgctc 116400
ttcataagca atgccgcaca gtgtggggat gtaaggagaa gaccaagata atgacaataa 116460
atcatggttg gcctttattg agcaccgttt atgtcagtta ttgtgctagc actttacatg 116520
catcaactca tttcactgga gggaggcacc tccttagaac ctgaggtcac cagccaatac 116580
actggaagaa ctgagatttc agccaaggtt ctttgaaagc cacaccttct ccaccatggt 116640
gggcactatg gaaccctcgg cggcatcttt tgttgatggt tttgctttta ttttacagaa 116700
aaatgctgtg attgaaagcc tgcaggaaca agtaaacaac gccaaagaga agattgtgag 116760
gctgatgtca gctgagtgca cctatgacct cccagagggg gctgccccac ctgcctcttc 116820
cccgaacaag gacgtccagg cggtagcctc ggtccacacc ctggcagctg ctcaggggcc 116880
ttcgggtcac ctctctgact ttcagaatga tcctggcatg gctgcccggg attcccagtg 116940
cacttcaggg ccctcctcat atgcacaaag ccttgagggg cctgggaagg actccagctt 117000
ctccccaggg aaggaggaga agatatctga ctcaaaagac ttttctgatc atttagactc 117060
aggttgtagc cagaagccat ggactgagca aagcctgggt ccagaaagag gagaccaagt 117120
ccccatgaac cccagccaga gtctcctacc aganagaggc ggctcagatc cccagagaca 117180
gaggcatctg gagaactcag aggacccccc agagcggcgg tcacgggtta gttcagtaat 117240
cagggagaaa cttcaggagg tcttacaaga tctgggcctg ggccctgagg cttccctctc 117300
caccgccccc tcttgtcatc agcaaacctg gaagaacagt gctgccttca gcccccaaaa 117360
gatgcccctc tccaaggagc tcggctttag cccttacatg gtgaggagaa ggcgggcagc 117420
tcagcgggcc cgctcacact ttcctggctc tgcaccctca tctgtggggc atcgggcaaa 117480
caggactgtt cctggggcac acagcaggct acatgtgcag aatggggaca gccccagcct 117540
ggccccacaa actactgatt ccagagtacg aagaccttct tccaggaagc cttcactacc 117600
ttcagatcct caagacagac caggtaccct ggagggcagc aaacaaagcc agacagagcc 117660
cgagggggct agagggagca aagcagcctt tcttcgccag ccttctggtt ctggccgggc 117720
cccaagtcct gctgccccat gcctctccaa agcctcacct gacttgcctg aacagtggca 117780
gctgtggccc ccagtgccct caggctgtgc ctccctgtct tctcaacaca gctattttga 117840
tactgagtcc agcagctcag atgagttctt ctgccgctgc caccggccct actgtgaaat 117900
ctgcttccag agctcttctg actctagtga cagtggcaca tcagacactg accctgagcc 117960
tactgggggg ctggcttcct gggaaaagct gtgggcccgc tccaagccta ttgtgaactt 118020
caaagatgac ttgaaaccca cgctggtgtg aaaagcaaca gagctggtct agacacagag 118080
gtcagtccaa gagaagctgt accaaggccc acaggagaag agccaatttc tggtctttgg 118140
ggaacagatt agtgccctgc atttgaccag cccataccat gtttcagcta ggctcactgt 118200
gttactttga gtacttcttg atctataaaa agagaggcat tgcctgtcct gttactacct 118260
cgcagcctta ctataaaaga ctccagttga gtgactatga aagacactga ctccttggat 118320
aaaaggtgct gaatgaacac ataggatttt ctgtccaggt cagcctacat tctgtaaaac 118380
tcttaatata ttcagatgga tggctgaatg gacagacaga tggagagatg catgggaaat 118440
ttctgtagaa cttgaggtgt ggactgtgac ccatcaaact ggccttttgg tggacagacc 118500
taccaggaag ataagtctcc tacatccttg ggcctcccac tcctggaagg cagtggtttt 118560
atttctgctg aatgttgtga acagcacctc cctagattcc agcttctggc cagacccagc 118620
tcagagccac ccctacacca ctatttcttg atggtgtctt tccaccatta tggcacttta 118680
ccctcctctc tgagacagat ctccatgcgc ccgcaggctt cccagatctc tcccctggga 118740
tcggatgtac ctgaggtcct gactgtcccc actgtcccct tgtcctgtgg ctcatcctcg 118800
attcacccac tgatgcagtt ttgtactgcg gggaggcaca caccagcaat ttctgttggg 118860
gtatgggaga acctgttggt caagagtgct tttggttcca ttggggttac atgactacca 118920
acagacacat aaacctggaa gccaaatgga gaaataaaaa ggaagacacg agggacacga 118980
aaacaggaaa gaaaacagga tttgaatatt tcacttgagt ccagcatagt acttggcaat 119040
atcatatttt tgtgattcct tttgataacc ctgtgaagta gacactttca tttttacaga 119100
caaggattat gaggcttaga gaaatgaggt agtttcccgc aacatcacac tgctggacag 119160
agatgtacac acagctcctg ggactcaagt aggtgggttt tcccagggac acatggcttc 119220
atgtgttctt ctgggaatgg caggtgacgc ttggcagacg agacaacaaa gcaaggctca 119280
tgtaagaaag ctgggatgtg ctcccctata gtccagaata atagacctgg gtcctcacct 119340
caggaaacgg gcctccactt cctcactgcc aaaggccaca ctggcacctc ccaagggagc 119400
tggggagctg gtgaaggatg agtgcgagga actcagccac caccagagcc acagggagag 119460
cacacctggg tccactgtgc ttattgctga gctggctgtc atgtccaggc tgtcccctgc 119520
cccgagtcct gtgtatacat ctgtgggtgt gcacatgttt gcatgaagga attcaggcct 119580
tattaaatat tctcagaggg gggcatttgg ctctaaatgt atcatcaatt tatcatggaa 119640
tcttgggggc tgctgacacc cctggactct ccaggcactg aaccatgagg ccctcctgga 119700
agcacagctt cttctatcat ctacttttaa acaggaattt cctaatttat tctgtgcatg 119760
ggtttgcagt ttcttgtgct gtgtgtgtgc tgtccaagtg gtaccataat aaaagagaaa 119820
tgactcccga gaggagtctt ttcagaaact gtaatctggg gctggccagg aggggcccgg 119880
agaaggctga cccacccaaa gaaggggaac cagagaagcc atcagagctg ctgccgggct 119940
accctgggtc ccagtgtacc ttctaccaaa gttccatttg aacagattct tctgtgttct 120000
ccctaagaag cctcttatcc cagaaacact ccctcaatgg acataggaaa ccctggagac 120060
cctggactct tcctgcccct gggggtcctg tggctgggct ccccctcctg cagctccctt 120120
cctcccagca tgccaccact agcagcccac cattcattca tgtggactct aaatctggca 120180
atccttctag ccttctcact ctgtctgctt ctagaacctt agtcccacca tccccgccct 120240
tctacatctc catccttctg tttagaattt tttttcccac tttgtgccct tgtgaattat 120300
tcatccttca aggctcaggt ggagcataca ttctttcttc aacctttccc agccatcccc 120360
aaagaaagct gattgattcc ctagttaaat aaggaaggat gggctggaag cagtggctca 120420
cgtctgtaat cccagcac 120438
<210> 13
<211> 2442
<212> DNA
<213> Artificial Sequence
<220>
<223> Wild type GPR156 isoform 1 cDNA
<220>
<221> variation
<222> (1548) .. (1548)
<223> n is a, g, t, or c
<400> 13
atggagcctg aaataaactg ctctgaattg tgtgacagtt ttcctggcca ggagctggat 60
cggagacccc ttcatgatct ctgcaagaca acaattacat cttcccacca cagcagtaag 120
accatctctt cattatctcc tgtcctcttg ggtattgttt ggacttttct cagctgtgga 180
cttctgctga tacttttctt tcttgccttt acaattcact gcaggaagaa caggattgtg 240
aagatgtcca gtcccaatct gaacattgtg accttactgg gcagttgtct cacttacagt 300
agcgcttacc tctttgggat tcaggatgtt ttagtgggga gctcaatgga aactctcatt 360
cagacaagac tgtccatgct gtgcattggg acctcccttg tgtttggccc cattctggga 420
aagagctggc gactctacaa ggtgtttacc caaagggtcc cggacaagag agtgattatc 480
aaagacctgc agttgctggg gttggtggca gccctgttga tggctgatgt gatcctgctc 540
atgacgtggg tgctgactga tcccatccag tgcctccaga ttctcagtgt cagtatgacg 600
gtgacaggga aagacgtgtc ctgcacttcg accagcaccc acttctgtgc ttcccggtat 660
tccgatgttt ggattgctct catttgggga tgcaagggtc tgctcctgct gtatggtgcc 720
tacctggctg gcctgactgg ccatgtcagc tcccctcctg tgaatcagtc cttaaccatc 780
atggtggggg tcaacctcct tgtactggct gctgggctgc tttttgtagt caccagatac 840
ttgcattcct ggcccaacct ggtctttgga ctcacatctg gagggatctt tgtttgtaca 900
actacaatca actgcttcat cttcattccc cagctgaagc aatggaaggc atttgaagag 960
gaaaaccaaa caatcagacg catggccaaa tatttcagca ctcccaacaa aagcttccat 1020
acccagtatg gtgaggagga gaactgccac ccgaggggag agaaaagctc catggagagg 1080
ctcctcacag aaaaaaatgc tgtgattgaa agcctgcagg aacaagtaaa caacgccaaa 1140
gagaagattg tgaggctgat gtcagctgag tgcacctatg acctcccaga gggggctgcc 1200
ccacctgcct cttccccgaa caaggacgtc caggcggtag cctcggtcca caccctggca 1260
gctgctcagg ggccttcggg tcacctctct gactttcaga atgatcctgg catggctgcc 1320
cgggattccc agtgcacttc agggccctcc tcatatgcac aaagccttga ggggcctggg 1380
aaggactcca gcttctcccc agggaaggag gagaagatat ctgactcaaa agacttttct 1440
gatcatttag actcaggttg tagccagaag ccatggactg agcaaagcct gggtccagaa 1500
agaggagacc aagtccccat gaaccccagc cagagtctcc taccaganag aggcggctca 1560
gatccccaga gacagaggca tctggagaac tcagaggagc ccccagagcg gcggtcacgg 1620
gttagttcag taatcaggga gaaacttcag gaggtcttac aagatctggg cctgggccct 1680
gaggcttccc tctccaccgc cccctcttgt catcagcaaa cctggaagaa cagtgctgcc 1740
ttcagccccc aaaagatgcc cctctccaag gagctcggct ttagccctta catggtgagg 1800
agaaggcggg cagctcagcg ggcccgctca cactttcctg gctctgcacc ctcatctgtg 1860
gggcatcggg caaacaggac tgttcctggg gcacacagca ggctacatgt gcagaatggg 1920
gacagcccca gcctggcccc acaaactact gattccagag tacgaagacc ttcttccagg 1980
aagccttcac taccttcaga tcctcaagac agaccaggta ccctggaggg cagcaaacaa 2040
agccagacag agcccgaggg ggctagaggg agcaaagcag cctttcttcg ccagccttct 2100
ggttctggcc gggccccaag tcctgctgcc ccatgcctct ccaaagcctc acctgacttg 2160
cctgaacagt ggcagctgtg gcccccagtg ccctcaggct gtgcctccct gtcttctcaa 2220
cacagctatt ttgatactga gtccagcagc tcagatgagt tcttctgccg ctgccaccgg 2280
ccctactgtg aaatctgctt ccagagctct tctgactcta gtgacagtgg cacatcagac 2340
actgaccctg agcctactgg ggggctggct tcctgggaaa agctgtgggc ccgctccaag 2400
cctattgtga acttcaaaga tgacttgaaa cccacgctgg tg 2442
<210> 14
<211> 2430
<212> DNA
<213> Artificial Sequence
<220>
<223> Wild type GPR156 isoform 2 cDNA
<220>
<221> variation
<222> (1536) .. (1536)
<223> n is a, g, t, or c
<400> 14
atggagcctg aaataaactg ctctgaattg tgtgacagtt ttcctggcca ggagctggat 60
cggagacccc ttcatgatct ctgcaagaca acaattacat cttcccacca cagcagtaag 120
accatctctt cattatctcc tgtcctcttg ggtattgttt ggacttttct cagctgtgga 180
cttctgctga tacttttctt tcttgccttt acaattcact gcaggaagaa caggattgtg 240
aagatgtcca gtcccaatct gaacattgtg accttactgg gcagttgtct cacttacagt 300
agcgcttacc tctttgggat tcaggatgtt ttagtgggga gctcaatgga aactctcatt 360
cagacaagac tgtccatgct gtgcattggg acctcccttg tgtttggccc cattctggga 420
aagagctggc gactctacaa ggtgtttacc caaagggtcc cggacaagag agtgattatc 480
aaagacctgc agttgctggg gttggtggca gccctgttga tggctgatgt gatcctgctc 540
atgacgtggg tgctgactga tcccatccag tgcctccaga ttctcagtgt gacagggaaa 600
gacgtgtcct gcacttcgac cagcacccac ttctgtgctt cccggtattc cgatgtttgg 660
attgctctca tttggggatg caagggtctg ctcctgctgt atggtgccta cctggctggc 720
ctgactggcc atgtcagctc ccctcctgtg aatcagtcct taaccatcat ggtgggggtc 780
aacctccttg tactggctgc tgggctgctt tttgtagtca ccagatactt gcattcctgg 840
cccaacctgg tctttggact cacatctgga gggatctttg tttgtacaac tacaatcaac 900
tgcttcatct tcattcccca gctgaagcaa tggaaggcat ttgaagagga aaaccaaaca 960
atcagacgca tggccaaata tttcagcact cccaacaaaa gcttccatac ccagtatggt 1020
gaggaggaga actgccaccc gaggggagag aaaagctcca tggagaggct cctcacagaa 1080
aaaaatgctg tgattgaaag cctgcaggaa caagtaaaca acgccaaaga gaagattgtg 1140
aggctgatgt cagctgagtg cacctatgac ctcccagagg gggctgcccc acctgcctct 1200
tccccgaaca aggacgtcca ggcggtagcc tcggtccaca ccctggcagc tgctcagggg 1260
ccttcgggtc acctctctga ctttcagaat gatcctggca tggctgcccg ggattcccag 1320
tgcacttcag ggccctcctc atatgcacaa agccttgagg ggcctgggaa ggactccagc 1380
ttctccccag ggaaggagga gaagatatct gactcaaaag acttttctga tcatttagac 1440
tcaggttgta gccagaagcc atggactgag caaagcctgg gtccagaaag aggagaccaa 1500
gtccccatga accccagcca gagtctccta ccaganagag gcggctcaga tccccagaga 1560
cagaggcatc tggagaactc agaggagccc ccagagcggc ggtcacgggt tagttcagta 1620
atcagggaga aacttcagga ggtcttacaa gatctgggcc tgggccctga ggcttccctc 1680
tccaccgccc cctcttgtca tcagcaaacc tggaagaaca gtgctgcctt cagcccccaa 1740
aagatgcccc tctccaagga gctcggcttt agcccttaca tggtgaggag aaggcgggca 1800
gctcagcggg cccgctcaca ctttcctggc tctgcaccct catctgtggg gcatcgggca 1860
aacaggactg ttcctggggc acacagcagg ctacatgtgc agaatgggga cagccccagc 1920
ctggccccac aaactactga ttccagagta cgaagacctt cttccaggaa gccttcacta 1980
ccttcagatc ctcaagacag accaggtacc ctggagggca gcaaacaaag ccagacagag 2040
cccgaggggg ctagagggag caaagcagcc tttcttcgcc agccttctgg ttctggccgg 2100
gccccaagtc ctgctgcccc atgcctctcc aaagcctcac ctgacttgcc tgaacagtgg 2160
cagctgtggc ccccagtgcc ctcaggctgt gcctccctgt cttctcaaca cagctatttt 2220
gatactgagt ccagcagctc agatgagttc ttctgccgct gccaccggcc ctactgtgaa 2280
atctgcttcc agagctcttc tgactctagt gacagtggca catcagacac tgaccctgag 2340
cctactgggg ggctggcttc ctgggaaaag ctgtgggccc gctccaagcc tattgtgaac 2400
ttcaaagatg acttgaaacc cacgctggtg 2430
<210> 15
<211> 1515
<212> DNA
<213> Artificial Sequence
<220>
<223> Wild type GPR156 cDNA, fragment 310-814
<220>
<221> variation
<222> (621) .. (621)
<223> n is a, g, t, or c
<400> 15
ccccagctga agcaatggaa ggcatttgaa gaggaaaacc aaacaatcag acgcatggcc 60
aaatatttca gcactcccaa caaaagcttc catacccagt atggtgagga ggagaactgc 120
cacccgaggg gagagaaaag ctccatggag aggctcctca cagaaaaaaa tgctgtgatt 180
gaaagcctgc aggaacaagt aaacaacgcc aaagagaaga ttgtgaggct gatgtcagct 240
gagtgcacct atgacctccc agagggggct gccccacctg cctcttcccc gaacaaggac 300
gtccaggcgg tagcctcggt ccacaccctg gcagctgctc aggggccttc gggtcacctc 360
tctgactttc agaatgatcc tggcatggct gcccgggatt cccagtgcac ttcagggccc 420
tcctcatatg cacaaagcct tgaggggcct gggaaggact ccagcttctc cccagggaag 480
gaggagaaga tatctgactc aaaagacttt tctgatcatt tagactcagg ttgtagccag 540
aagccatgga ctgagcaaag cctgggtcca gaaagaggag accaagtccc catgaacccc 600
agccagagtc tcctaccaga nagaggcggc tcagatcccc agagacagag gcatctggag 660
aactcagagg agcccccaga gcggcggtca cgggttagtt cagtaatcag ggagaaactt 720
caggaggtct tacaagatct gggcctgggc cctgaggctt ccctctccac cgccccctct 780
tgtcatcagc aaacctggaa gaacagtgct gccttcagcc cccaaaagat gcccctctcc 840
aaggagctcg gctttagccc ttacatggtg aggagaaggc gggcagctca gcgggcccgc 900
tcacactttc ctggctctgc accctcatct gtggggcatc gggcaaacag gactgttcct 960
ggggcacaca gcaggctaca tgtgcagaat ggggacagcc ccagcctggc cccacaaact 1020
actgattcca gagtacgaag accttcttcc aggaagcctt cactaccttc agatcctcaa 1080
gacagaccag gtaccctgga gggcagcaaa caaagccaga cagagcccga gggggctaga 1140
gggagcaaag cagcctttct tcgccagcct tctggttctg gccgggcccc aagtcctgct 1200
gccccatgcc tctccaaagc ctcacctgac ttgcctgaac agtggcagct gtggccccca 1260
gtgccctcag gctgtgcctc cctgtcttct caacacagct attttgatac tgagtccagc 1320
agctcagatg agttcttctg ccgctgccac cggccctact gtgaaatctg cttccagagc 1380
tcttctgact ctagtgacag tggcacatca gacactgacc ctgagcctac tggggggctg 1440
gcttcctggg aaaagctgtg ggcccgctcc aagcctattg tgaacttcaa agatgacttg 1500
aaacccacgc tggtg 1515
<210> 16
<211> 2442
<212> DNA
<213> Artificial Sequence
<220>
<223> E533D GPR156 GAT cDNA
<220>
<221> variation
<222> (1548) .. (1548)
<223> n is a, g, t, or c
<400> 16
atggagcctg aaataaactg ctctgaattg tgtgacagtt ttcctggcca ggagctggat 60
cggagacccc ttcatgatct ctgcaagaca acaattacat cttcccacca cagcagtaag 120
accatctctt cattatctcc tgtcctcttg ggtattgttt ggacttttct cagctgtgga 180
cttctgctga tacttttctt tcttgccttt acaattcact gcaggaagaa caggattgtg 240
aagatgtcca gtcccaatct gaacattgtg accttactgg gcagttgtct cacttacagt 300
agcgcttacc tctttgggat tcaggatgtt ttagtgggga gctcaatgga aactctcatt 360
cagacaagac tgtccatgct gtgcattggg acctcccttg tgtttggccc cattctggga 420
aagagctggc gactctacaa ggtgtttacc caaagggtcc cggacaagag agtgattatc 480
aaagacctgc agttgctggg gttggtggca gccctgttga tggctgatgt gatcctgctc 540
atgacgtggg tgctgactga tcccatccag tgcctccaga ttctcagtgt cagtatgacg 600
gtgacaggga aagacgtgtc ctgcacttcg accagcaccc acttctgtgc ttcccggtat 660
tccgatgttt ggattgctct catttgggga tgcaagggtc tgctcctgct gtatggtgcc 720
tacctggctg gcctgactgg ccatgtcagc tcccctcctg tgaatcagtc cttaaccatc 780
atggtggggg tcaacctcct tgtactggct gctgggctgc tttttgtagt caccagatac 840
ttgcattcct ggcccaacct ggtctttgga ctcacatctg gagggatctt tgtttgtaca 900
actacaatca actgcttcat cttcattccc cagctgaagc aatggaaggc atttgaagag 960
gaaaaccaaa caatcagacg catggccaaa tatttcagca ctcccaacaa aagcttccat 1020
acccagtatg gtgaggagga gaactgccac ccgaggggag agaaaagctc catggagagg 1080
ctcctcacag aaaaaaatgc tgtgattgaa agcctgcagg aacaagtaaa caacgccaaa 1140
gagaagattg tgaggctgat gtcagctgag tgcacctatg acctcccaga gggggctgcc 1200
ccacctgcct cttccccgaa caaggacgtc caggcggtag cctcggtcca caccctggca 1260
gctgctcagg ggccttcggg tcacctctct gactttcaga atgatcctgg catggctgcc 1320
cgggattccc agtgcacttc agggccctcc tcatatgcac aaagccttga ggggcctggg 1380
aaggactcca gcttctcccc agggaaggag gagaagatat ctgactcaaa agacttttct 1440
gatcatttag actcaggttg tagccagaag ccatggactg agcaaagcct gggtccagaa 1500
agaggagacc aagtccccat gaaccccagc cagagtctcc taccaganag aggcggctca 1560
gatccccaga gacagaggca tctggagaac tcagaggatc ccccagagcg gcggtcacgg 1620
gttagttcag taatcaggga gaaacttcag gaggtcttac aagatctggg cctgggccct 1680
gaggcttccc tctccaccgc cccctcttgt catcagcaaa cctggaagaa cagtgctgcc 1740
ttcagccccc aaaagatgcc cctctccaag gagctcggct ttagccctta catggtgagg 1800
agaaggcggg cagctcagcg ggcccgctca cactttcctg gctctgcacc ctcatctgtg 1860
gggcatcggg caaacaggac tgttcctggg gcacacagca ggctacatgt gcagaatggg 1920
gacagcccca gcctggcccc acaaactact gattccagag tacgaagacc ttcttccagg 1980
aagccttcac taccttcaga tcctcaagac agaccaggta ccctggaggg cagcaaacaa 2040
agccagacag agcccgaggg ggctagaggg agcaaagcag cctttcttcg ccagccttct 2100
ggttctggcc gggccccaag tcctgctgcc ccatgcctct ccaaagcctc acctgacttg 2160
cctgaacagt ggcagctgtg gcccccagtg ccctcaggct gtgcctccct gtcttctcaa 2220
cacagctatt ttgatactga gtccagcagc tcagatgagt tcttctgccg ctgccaccgg 2280
ccctactgtg aaatctgctt ccagagctct tctgactcta gtgacagtgg cacatcagac 2340
actgaccctg agcctactgg ggggctggct tcctgggaaa agctgtgggc ccgctccaag 2400
cctattgtga acttcaaaga tgacttgaaa cccacgctgg tg 2442
<210> 17
<211> 2442
<212> DNA
<213> Artificial Sequence
<220>
<223> E533D GPR156 GAC cDNA
<220>
<221> variation
<222> (1548) .. (1548)
<223> n is a, g, t, or c
<400> 17
atggagcctg aaataaactg ctctgaattg tgtgacagtt ttcctggcca ggagctggat 60
cggagacccc ttcatgatct ctgcaagaca acaattacat cttcccacca cagcagtaag 120
accatctctt cattatctcc tgtcctcttg ggtattgttt ggacttttct cagctgtgga 180
cttctgctga tacttttctt tcttgccttt acaattcact gcaggaagaa caggattgtg 240
aagatgtcca gtcccaatct gaacattgtg accttactgg gcagttgtct cacttacagt 300
agcgcttacc tctttgggat tcaggatgtt ttagtgggga gctcaatgga aactctcatt 360
cagacaagac tgtccatgct gtgcattggg acctcccttg tgtttggccc cattctggga 420
aagagctggc gactctacaa ggtgtttacc caaagggtcc cggacaagag agtgattatc 480
aaagacctgc agttgctggg gttggtggca gccctgttga tggctgatgt gatcctgctc 540
atgacgtggg tgctgactga tcccatccag tgcctccaga ttctcagtgt cagtatgacg 600
gtgacaggga aagacgtgtc ctgcacttcg accagcaccc acttctgtgc ttcccggtat 660
tccgatgttt ggattgctct catttgggga tgcaagggtc tgctcctgct gtatggtgcc 720
tacctggctg gcctgactgg ccatgtcagc tcccctcctg tgaatcagtc cttaaccatc 780
atggtggggg tcaacctcct tgtactggct gctgggctgc tttttgtagt caccagatac 840
ttgcattcct ggcccaacct ggtctttgga ctcacatctg gagggatctt tgtttgtaca 900
actacaatca actgcttcat cttcattccc cagctgaagc aatggaaggc atttgaagag 960
gaaaaccaaa caatcagacg catggccaaa tatttcagca ctcccaacaa aagcttccat 1020
acccagtatg gtgaggagga gaactgccac ccgaggggag agaaaagctc catggagagg 1080
ctcctcacag aaaaaaatgc tgtgattgaa agcctgcagg aacaagtaaa caacgccaaa 1140
gagaagattg tgaggctgat gtcagctgag tgcacctatg acctcccaga gggggctgcc 1200
ccacctgcct cttccccgaa caaggacgtc caggcggtag cctcggtcca caccctggca 1260
gctgctcagg ggccttcggg tcacctctct gactttcaga atgatcctgg catggctgcc 1320
cgggattccc agtgcacttc agggccctcc tcatatgcac aaagccttga ggggcctggg 1380
aaggactcca gcttctcccc agggaaggag gagaagatat ctgactcaaa agacttttct 1440
gatcatttag actcaggttg tagccagaag ccatggactg agcaaagcct gggtccagaa 1500
agaggagacc aagtccccat gaaccccagc cagagtctcc taccaganag aggcggctca 1560
gatccccaga gacagaggca tctggagaac tcagaggacc ccccagagcg gcggtcacgg 1620
gttagttcag taatcaggga gaaacttcag gaggtcttac aagatctggg cctgggccct 1680
gaggcttccc tctccaccgc cccctcttgt catcagcaaa cctggaagaa cagtgctgcc 1740
ttcagccccc aaaagatgcc cctctccaag gagctcggct ttagccctta catggtgagg 1800
agaaggcggg cagctcagcg ggcccgctca cactttcctg gctctgcacc ctcatctgtg 1860
gggcatcggg caaacaggac tgttcctggg gcacacagca ggctacatgt gcagaatggg 1920
gacagcccca gcctggcccc acaaactact gattccagag tacgaagacc ttcttccagg 1980
aagccttcac taccttcaga tcctcaagac agaccaggta ccctggaggg cagcaaacaa 2040
agccagacag agcccgaggg ggctagaggg agcaaagcag cctttcttcg ccagccttct 2100
ggttctggcc gggccccaag tcctgctgcc ccatgcctct ccaaagcctc acctgacttg 2160
cctgaacagt ggcagctgtg gcccccagtg ccctcaggct gtgcctccct gtcttctcaa 2220
cacagctatt ttgatactga gtccagcagc tcagatgagt tcttctgccg ctgccaccgg 2280
ccctactgtg aaatctgctt ccagagctct tctgactcta gtgacagtgg cacatcagac 2340
actgaccctg agcctactgg ggggctggct tcctgggaaa agctgtgggc ccgctccaag 2400
cctattgtga acttcaaaga tgacttgaaa cccacgctgg tg 2442
<210> 18
<211> 2430
<212> DNA
<213> Artificial Sequence
<220>
<223> E529D GPR156 GAT cDNA
<220>
<221> variation
<222> (1536) .. (1536)
<223> n is a, g, t, or c
<400> 18
atggagcctg aaataaactg ctctgaattg tgtgacagtt ttcctggcca ggagctggat 60
cggagacccc ttcatgatct ctgcaagaca acaattacat cttcccacca cagcagtaag 120
accatctctt cattatctcc tgtcctcttg ggtattgttt ggacttttct cagctgtgga 180
cttctgctga tacttttctt tcttgccttt acaattcact gcaggaagaa caggattgtg 240
aagatgtcca gtcccaatct gaacattgtg accttactgg gcagttgtct cacttacagt 300
agcgcttacc tctttgggat tcaggatgtt ttagtgggga gctcaatgga aactctcatt 360
cagacaagac tgtccatgct gtgcattggg acctcccttg tgtttggccc cattctggga 420
aagagctggc gactctacaa ggtgtttacc caaagggtcc cggacaagag agtgattatc 480
aaagacctgc agttgctggg gttggtggca gccctgttga tggctgatgt gatcctgctc 540
atgacgtggg tgctgactga tcccatccag tgcctccaga ttctcagtgt gacagggaaa 600
gacgtgtcct gcacttcgac cagcacccac ttctgtgctt cccggtattc cgatgtttgg 660
attgctctca tttggggatg caagggtctg ctcctgctgt atggtgccta cctggctggc 720
ctgactggcc atgtcagctc ccctcctgtg aatcagtcct taaccatcat ggtgggggtc 780
aacctccttg tactggctgc tgggctgctt tttgtagtca ccagatactt gcattcctgg 840
cccaacctgg tctttggact cacatctgga gggatctttg tttgtacaac tacaatcaac 900
tgcttcatct tcattcccca gctgaagcaa tggaaggcat ttgaagagga aaaccaaaca 960
atcagacgca tggccaaata tttcagcact cccaacaaaa gcttccatac ccagtatggt 1020
gaggaggaga actgccaccc gaggggagag aaaagctcca tggagaggct cctcacagaa 1080
aaaaatgctg tgattgaaag cctgcaggaa caagtaaaca acgccaaaga gaagattgtg 1140
aggctgatgt cagctgagtg cacctatgac ctcccagagg gggctgcccc acctgcctct 1200
tccccgaaca aggacgtcca ggcggtagcc tcggtccaca ccctggcagc tgctcagggg 1260
ccttcgggtc acctctctga ctttcagaat gatcctggca tggctgcccg ggattcccag 1320
tgcacttcag ggccctcctc atatgcacaa agccttgagg ggcctgggaa ggactccagc 1380
ttctccccag ggaaggagga gaagatatct gactcaaaag acttttctga tcatttagac 1440
tcaggttgta gccagaagcc atggactgag caaagcctgg gtccagaaag aggagaccaa 1500
gtccccatga accccagcca gagtctccta ccaganagag gcggctcaga tccccagaga 1560
cagaggcatc tggagaactc agaggatccc ccagagcggc ggtcacgggt tagttcagta 1620
atcagggaga aacttcagga ggtcttacaa gatctgggcc tgggccctga ggcttccctc 1680
tccaccgccc cctcttgtca tcagcaaacc tggaagaaca gtgctgcctt cagcccccaa 1740
aagatgcccc tctccaagga gctcggcttt agcccttaca tggtgaggag aaggcgggca 1800
gctcagcggg cccgctcaca ctttcctggc tctgcaccct catctgtggg gcatcgggca 1860
aacaggactg ttcctggggc acacagcagg ctacatgtgc agaatgggga cagccccagc 1920
ctggccccac aaactactga ttccagagta cgaagacctt cttccaggaa gccttcacta 1980
ccttcagatc ctcaagacag accaggtacc ctggagggca gcaaacaaag ccagacagag 2040
cccgaggggg ctagagggag caaagcagcc tttcttcgcc agccttctgg ttctggccgg 2100
gccccaagtc ctgctgcccc atgcctctcc aaagcctcac ctgacttgcc tgaacagtgg 2160
cagctgtggc ccccagtgcc ctcaggctgt gcctccctgt cttctcaaca cagctatttt 2220
gatactgagt ccagcagctc agatgagttc ttctgccgct gccaccggcc ctactgtgaa 2280
atctgcttcc agagctcttc tgactctagt gacagtggca catcagacac tgaccctgag 2340
cctactgggg ggctggcttc ctgggaaaag ctgtgggccc gctccaagcc tattgtgaac 2400
ttcaaagatg acttgaaacc cacgctggtg 2430
<210> 19
<211> 2430
<212> DNA
<213> Artificial Sequence
<220>
<223> E529D GPR156 GAC cDNA
<220>
<221> variation
<222> (1536) .. (1536)
<223> n is a, g, t, or c
<400> 19
atggagcctg aaataaactg ctctgaattg tgtgacagtt ttcctggcca ggagctggat 60
cggagacccc ttcatgatct ctgcaagaca acaattacat cttcccacca cagcagtaag 120
accatctctt cattatctcc tgtcctcttg ggtattgttt ggacttttct cagctgtgga 180
cttctgctga tacttttctt tcttgccttt acaattcact gcaggaagaa caggattgtg 240
aagatgtcca gtcccaatct gaacattgtg accttactgg gcagttgtct cacttacagt 300
agcgcttacc tctttgggat tcaggatgtt ttagtgggga gctcaatgga aactctcatt 360
cagacaagac tgtccatgct gtgcattggg acctcccttg tgtttggccc cattctggga 420
aagagctggc gactctacaa ggtgtttacc caaagggtcc cggacaagag agtgattatc 480
aaagacctgc agttgctggg gttggtggca gccctgttga tggctgatgt gatcctgctc 540
atgacgtggg tgctgactga tcccatccag tgcctccaga ttctcagtgt gacagggaaa 600
gacgtgtcct gcacttcgac cagcacccac ttctgtgctt cccggtattc cgatgtttgg 660
attgctctca tttggggatg caagggtctg ctcctgctgt atggtgccta cctggctggc 720
ctgactggcc atgtcagctc ccctcctgtg aatcagtcct taaccatcat ggtgggggtc 780
aacctccttg tactggctgc tgggctgctt tttgtagtca ccagatactt gcattcctgg 840
cccaacctgg tctttggact cacatctgga gggatctttg tttgtacaac tacaatcaac 900
tgcttcatct tcattcccca gctgaagcaa tggaaggcat ttgaagagga aaaccaaaca 960
atcagacgca tggccaaata tttcagcact cccaacaaaa gcttccatac ccagtatggt 1020
gaggaggaga actgccaccc gaggggagag aaaagctcca tggagaggct cctcacagaa 1080
aaaaatgctg tgattgaaag cctgcaggaa caagtaaaca acgccaaaga gaagattgtg 1140
aggctgatgt cagctgagtg cacctatgac ctcccagagg gggctgcccc acctgcctct 1200
tccccgaaca aggacgtcca ggcggtagcc tcggtccaca ccctggcagc tgctcagggg 1260
ccttcgggtc acctctctga ctttcagaat gatcctggca tggctgcccg ggattcccag 1320
tgcacttcag ggccctcctc atatgcacaa agccttgagg ggcctgggaa ggactccagc 1380
ttctccccag ggaaggagga gaagatatct gactcaaaag acttttctga tcatttagac 1440
tcaggttgta gccagaagcc atggactgag caaagcctgg gtccagaaag aggagaccaa 1500
gtccccatga accccagcca gagtctccta ccaganagag gcggctcaga tccccagaga 1560
cagaggcatc tggagaactc agaggacccc ccagagcggc ggtcacgggt tagttcagta 1620
atcagggaga aacttcagga ggtcttacaa gatctgggcc tgggccctga ggcttccctc 1680
tccaccgccc cctcttgtca tcagcaaacc tggaagaaca gtgctgcctt cagcccccaa 1740
aagatgcccc tctccaagga gctcggcttt agcccttaca tggtgaggag aaggcgggca 1800
gctcagcggg cccgctcaca ctttcctggc tctgcaccct catctgtggg gcatcgggca 1860
aacaggactg ttcctggggc acacagcagg ctacatgtgc agaatgggga cagccccagc 1920
ctggccccac aaactactga ttccagagta cgaagacctt cttccaggaa gccttcacta 1980
ccttcagatc ctcaagacag accaggtacc ctggagggca gcaaacaaag ccagacagag 2040
cccgaggggg ctagagggag caaagcagcc tttcttcgcc agccttctgg ttctggccgg 2100
gccccaagtc ctgctgcccc atgcctctcc aaagcctcac ctgacttgcc tgaacagtgg 2160
cagctgtggc ccccagtgcc ctcaggctgt gcctccctgt cttctcaaca cagctatttt 2220
gatactgagt ccagcagctc agatgagttc ttctgccgct gccaccggcc ctactgtgaa 2280
atctgcttcc agagctcttc tgactctagt gacagtggca catcagacac tgaccctgag 2340
cctactgggg ggctggcttc ctgggaaaag ctgtgggccc gctccaagcc tattgtgaac 2400
ttcaaagatg acttgaaacc cacgctggtg 2430
<210> 20
<211> 1515
<212> DNA
<213> Artificial Sequence
<220>
<223> E533D GPR156 GAT cDNA, fragment 310-814
<220>
<221> variation
<222> (621) .. (621)
<223> n is a, g, t, or c
<400> 20
ccccagctga agcaatggaa ggcatttgaa gaggaaaacc aaacaatcag acgcatggcc 60
aaatatttca gcactcccaa caaaagcttc catacccagt atggtgagga ggagaactgc 120
cacccgaggg gagagaaaag ctccatggag aggctcctca cagaaaaaaa tgctgtgatt 180
gaaagcctgc aggaacaagt aaacaacgcc aaagagaaga ttgtgaggct gatgtcagct 240
gagtgcacct atgacctccc agagggggct gccccacctg cctcttcccc gaacaaggac 300
gtccaggcgg tagcctcggt ccacaccctg gcagctgctc aggggccttc gggtcacctc 360
tctgactttc agaatgatcc tggcatggct gcccgggatt cccagtgcac ttcagggccc 420
tcctcatatg cacaaagcct tgaggggcct gggaaggact ccagcttctc cccagggaag 480
gaggagaaga tatctgactc aaaagacttt tctgatcatt tagactcagg ttgtagccag 540
aagccatgga ctgagcaaag cctgggtcca gaaagaggag accaagtccc catgaacccc 600
agccagagtc tcctaccaga nagaggcggc tcagatcccc agagacagag gcatctggag 660
aactcagagg atcccccaga gcggcggtca cgggttagtt cagtaatcag ggagaaactt 720
caggaggtct tacaagatct gggcctgggc cctgaggctt ccctctccac cgccccctct 780
tgtcatcagc aaacctggaa gaacagtgct gccttcagcc cccaaaagat gcccctctcc 840
aaggagctcg gctttagccc ttacatggtg aggagaaggc gggcagctca gcgggcccgc 900
tcacactttc ctggctctgc accctcatct gtggggcatc gggcaaacag gactgttcct 960
ggggcacaca gcaggctaca tgtgcagaat ggggacagcc ccagcctggc cccacaaact 1020
actgattcca gagtacgaag accttcttcc aggaagcctt cactaccttc agatcctcaa 1080
gacagaccag gtaccctgga gggcagcaaa caaagccaga cagagcccga gggggctaga 1140
gggagcaaag cagcctttct tcgccagcct tctggttctg gccgggcccc aagtcctgct 1200
gccccatgcc tctccaaagc ctcacctgac ttgcctgaac agtggcagct gtggccccca 1260
gtgccctcag gctgtgcctc cctgtcttct caacacagct attttgatac tgagtccagc 1320
agctcagatg agttcttctg ccgctgccac cggccctact gtgaaatctg cttccagagc 1380
tcttctgact ctagtgacag tggcacatca gacactgacc ctgagcctac tggggggctg 1440
gcttcctggg aaaagctgtg ggcccgctcc aagcctattg tgaacttcaa agatgacttg 1500
aaacccacgc tggtg 1515
<210> 21
<211> 1515
<212> DNA
<213> Artificial Sequence
<220>
<223> E533D GPR156 GAC cDNA, fragment 310-814
<220>
<221> variation
<222> (621) .. (621)
<223> n is a, g, t, or c
<400> 21
ccccagctga agcaatggaa ggcatttgaa gaggaaaacc aaacaatcag acgcatggcc 60
aaatatttca gcactcccaa caaaagcttc catacccagt atggtgagga ggagaactgc 120
cacccgaggg gagagaaaag ctccatggag aggctcctca cagaaaaaaa tgctgtgatt 180
gaaagcctgc aggaacaagt aaacaacgcc aaagagaaga ttgtgaggct gatgtcagct 240
gagtgcacct atgacctccc agagggggct gccccacctg cctcttcccc gaacaaggac 300
gtccaggcgg tagcctcggt ccacaccctg gcagctgctc aggggccttc gggtcacctc 360
tctgactttc agaatgatcc tggcatggct gcccgggatt cccagtgcac ttcagggccc 420
tcctcatatg cacaaagcct tgaggggcct gggaaggact ccagcttctc cccagggaag 480
gaggagaaga tatctgactc aaaagacttt tctgatcatt tagactcagg ttgtagccag 540
aagccatgga ctgagcaaag cctgggtcca gaaagaggag accaagtccc catgaacccc 600
agccagagtc tcctaccaga nagaggcggc tcagatcccc agagacagag gcatctggag 660
aactcagagg accccccaga gcggcggtca cgggttagtt cagtaatcag ggagaaactt 720
caggaggtct tacaagatct gggcctgggc cctgaggctt ccctctccac cgccccctct 780
tgtcatcagc aaacctggaa gaacagtgct gccttcagcc cccaaaagat gcccctctcc 840
aaggagctcg gctttagccc ttacatggtg aggagaaggc gggcagctca gcgggcccgc 900
tcacactttc ctggctctgc accctcatct gtggggcatc gggcaaacag gactgttcct 960
ggggcacaca gcaggctaca tgtgcagaat ggggacagcc ccagcctggc cccacaaact 1020
actgattcca gagtacgaag accttcttcc aggaagcctt cactaccttc agatcctcaa 1080
gacagaccag gtaccctgga gggcagcaaa caaagccaga cagagcccga gggggctaga 1140
gggagcaaag cagcctttct tcgccagcct tctggttctg gccgggcccc aagtcctgct 1200
gccccatgcc tctccaaagc ctcacctgac ttgcctgaac agtggcagct gtggccccca 1260
gtgccctcag gctgtgcctc cctgtcttct caacacagct attttgatac tgagtccagc 1320
agctcagatg agttcttctg ccgctgccac cggccctact gtgaaatctg cttccagagc 1380
tcttctgact ctagtgacag tggcacatca gacactgacc ctgagcctac tggggggctg 1440
gcttcctggg aaaagctgtg ggcccgctcc aagcctattg tgaacttcaa agatgacttg 1500
aaacccacgc tggtg 1515
<210> 22
<211> 2442
<212> DNA
<213> Artificial Sequence
<220>
<223> Wild Type GPR156 isoform 1 mRNA
<220>
<221> variation
<222> (1548) .. (1548)
<223> n is a, g, u, or c
<400> 22
auggagccug aaauaaacug cucugaauug ugugacaguu uuccuggcca ggagcuggau 60
cggagacccc uucaugaucu cugcaagaca acaauuacau cuucccacca cagcaguaag 120
accaucucuu cauuaucucc uguccucuug gguauuguuu ggacuuuucu cagcugugga 180
cuucugcuga uacuuuucuu ucuugccuuu acaauucacu gcaggaagaa caggauugug 240
aagaugucca gucccaaucu gaacauugug accuuacugg gcaguugucu cacuuacagu 300
agcgcuuacc ucuuugggau ucaggauguu uuagugggga gcucaaugga aacucucauu 360
cagacaagac uguccaugcu gugcauuggg accucccuug uguuuggccc cauucuggga 420
aagagcuggc gacucuacaa gguguuuacc caaagggucc cggacaagag agugauuauc 480
aaagaccugc aguugcuggg guugguggca gcccuguuga uggcugaugu gauccugcuc 540
augacguggg ugcugacuga ucccauccag ugccuccaga uucucagugu caguaugacg 600
gugacaggga aagacguguc cugcacuucg accagcaccc acuucugugc uucccgguau 660
uccgauguuu ggauugcucu cauuugggga ugcaaggguc ugcuccugcu guauggugcc 720
uaccuggcug gccugacugg ccaugucagc uccccuccug ugaaucaguc cuuaaccauc 780
augguggggg ucaaccuccu uguacuggcu gcugggcugc uuuuuguagu caccagauac 840
uugcauuccu ggcccaaccu ggucuuugga cucacaucug gagggaucuu uguuuguaca 900
acuacaauca acugcuucau cuucauuccc cagcugaagc aauggaaggc auuugaagag 960
gaaaaccaaa caaucagacg cauggccaaa uauuucagca cucccaacaa aagcuuccau 1020
acccaguaug gugaggagga gaacugccac ccgaggggag agaaaagcuc cauggagagg 1080
cuccucacag aaaaaaaugc ugugauugaa agccugcagg aacaaguaaa caacgccaaa 1140
gagaagauug ugaggcugau gucagcugag ugcaccuaug accucccaga gggggcugcc 1200
ccaccugccu cuuccccgaa caaggacguc caggcgguag ccucggucca cacccuggca 1260
gcugcucagg ggccuucggg ucaccucucu gacuuucaga augauccugg cauggcugcc 1320
cgggauuccc agugcacuuc agggcccucc ucauaugcac aaagccuuga ggggccuggg 1380
aaggacucca gcuucucccc agggaaggag gagaagauau cugacucaaa agacuuuucu 1440
gaucauuuag acucagguug uagccagaag ccauggacug agcaaagccu ggguccagaa 1500
agaggagacc aaguccccau gaaccccagc cagagucucc uaccaganag aggcggcuca 1560
gauccccaga gacagaggca ucuggagaac ucagaggagc ccccagagcg gcggucacgg 1620
guuaguucag uaaucaggga gaaacuucag gaggucuuac aagaucuggg ccugggcccu 1680
gaggcuuccc ucuccaccgc ccccucuugu caucagcaaa ccuggaagaa cagugcugcc 1740
uucagccccc aaaagaugcc ccucuccaag gagcucggcu uuagcccuua cauggugagg 1800
agaaggcggg cagcucagcg ggcccgcuca cacuuuccug gcucugcacc cucaucugug 1860
gggcaucggg caaacaggac uguuccuggg gcacacagca ggcuacaugu gcagaauggg 1920
gacagcccca gccuggcccc acaaacuacu gauuccagag uacgaagacc uucuuccagg 1980
aagccuucac uaccuucaga uccucaagac agaccaggua cccuggaggg cagcaaacaa 2040
agccagacag agcccgaggg ggcuagaggg agcaaagcag ccuuucuucg ccagccuucu 2100
gguucuggcc gggccccaag uccugcugcc ccaugccucu ccaaagccuc accugacuug 2160
ccugaacagu ggcagcugug gcccccagug cccucaggcu gugccucccu gucuucucaa 2220
cacagcuauu uugauacuga guccagcagc ucagaugagu ucuucugccg cugccaccgg 2280
cccuacugug aaaucugcuu ccagagcucu ucugacucua gugacagugg cacaucagac 2340
acugacccug agccuacugg ggggcuggcu uccugggaaa agcugugggc ccgcuccaag 2400
ccuauuguga acuucaaaga ugacuugaaa cccacgcugg ug 2442
<210> 23
<211> 2430
<212> DNA
<213> Homo sapien
<220>
<223> Wild Type GPR156 isoform 2 mRNA
<220>
<221> variation
<222> (1536) .. (1536)
<223> n is a, g, u, or c
<400> 23
auggagccug aaauaaacug cucugaauug ugugacaguu uuccuggcca ggagcuggau 60
cggagacccc uucaugaucu cugcaagaca acaauuacau cuucccacca cagcaguaag 120
accaucucuu cauuaucucc uguccucuug gguauuguuu ggacuuuucu cagcugugga 180
cuucugcuga uacuuuucuu ucuugccuuu acaauucacu gcaggaagaa caggauugug 240
aagaugucca gucccaaucu gaacauugug accuuacugg gcaguugucu cacuuacagu 300
agcgcuuacc ucuuugggau ucaggauguu uuagugggga gcucaaugga aacucucauu 360
cagacaagac uguccaugcu gugcauuggg accucccuug uguuuggccc cauucuggga 420
aagagcuggc gacucuacaa gguguuuacc caaagggucc cggacaagag agugauuauc 480
aaagaccugc aguugcuggg guugguggca gcccuguuga uggcugaugu gauccugcuc 540
augacguggg ugcugacuga ucccauccag ugccuccaga uucucagugu gacagggaaa 600
gacguguccu gcacuucgac cagcacccac uucugugcuu cccgguauuc cgauguuugg 660
auugcucuca uuuggggaug caagggucug cuccugcugu auggugccua ccuggcuggc 720
cugacuggcc augucagcuc cccuccugug aaucaguccu uaaccaucau gguggggguc 780
aaccuccuug uacuggcugc ugggcugcuu uuuguaguca ccagauacuu gcauuccugg 840
cccaaccugg ucuuuggacu cacaucugga gggaucuuug uuuguacaac uacaaucaac 900
ugcuucaucu ucauucccca gcugaagcaa uggaaggcau uugaagagga aaaccaaaca 960
aucagacgca uggccaaaua uuucagcacu cccaacaaaa gcuuccauac ccaguauggu 1020
gaggaggaga acugccaccc gaggggagag aaaagcucca uggagaggcu ccucacagaa 1080
aaaaaugcug ugauugaaag ccugcaggaa caaguaaaca acgccaaaga gaagauugug 1140
aggcugaugu cagcugagug caccuaugac cucccagagg gggcugcccc accugccucu 1200
uccccgaaca aggacgucca ggcgguagcc ucgguccaca cccuggcagc ugcucagggg 1260
ccuucggguc accucucuga cuuucagaau gauccuggca uggcugcccg ggauucccag 1320
ugcacuucag ggcccuccuc auaugcacaa agccuugagg ggccugggaa ggacuccagc 1380
uucuccccag ggaaggagga gaagauaucu gacucaaaag acuuuucuga ucauuuagac 1440
ucagguugua gccagaagcc auggacugag caaagccugg guccagaaag aggagaccaa 1500
guccccauga accccagcca gagucuccua ccaganagag gcggcucaga uccccagaga 1560
cagaggcauc uggagaacuc agaggagccc ccagagcggc ggucacgggu uaguucagua 1620
aucagggaga aacuucagga ggucuuacaa gaucugggcc ugggcccuga ggcuucccuc 1680
uccaccgccc ccucuuguca ucagcaaacc uggaagaaca gugcugccuu cagcccccaa 1740
aagaugcccc ucuccaagga gcucggcuuu agcccuuaca uggugaggag aaggcgggca 1800
gcucagcggg cccgcucaca cuuuccuggc ucugcacccu caucuguggg gcaucgggca 1860
aacaggacug uuccuggggc acacagcagg cuacaugugc agaaugggga cagccccagc 1920
cuggccccac aaacuacuga uuccagagua cgaagaccuu cuuccaggaa gccuucacua 1980
ccuucagauc cucaagacag accagguacc cuggagggca gcaaacaaag ccagacagag 2040
cccgaggggg cuagagggag caaagcagcc uuucuucgcc agccuucugg uucuggccgg 2100
gccccaaguc cugcugcccc augccucucc aaagccucac cugacuugcc ugaacagugg 2160
cagcuguggc ccccagugcc cucaggcugu gccucccugu cuucucaaca cagcuauuuu 2220
gauacugagu ccagcagcuc agaugaguuc uucugccgcu gccaccggcc cuacugugaa 2280
aucugcuucc agagcucuuc ugacucuagu gacaguggca caucagacac ugacccugag 2340
ccuacugggg ggcuggcuuc cugggaaaag cugugggccc gcuccaagcc uauugugaac 2400
uucaaagaug acuugaaacc cacgcuggug 2430
<210> 24
<211> 1515
<212> DNA
<213> Homo sapien
<220>
<223> Wild Type GPR156 mRNA, fragment 310-814
<220>
<221> variation
<222> (621) .. (621)
<223> n is a, g, u, or c
<400> 24
ccccagcuga agcaauggaa ggcauuugaa gaggaaaacc aaacaaucag acgcauggcc 60
aaauauuuca gcacucccaa caaaagcuuc cauacccagu auggugagga ggagaacugc 120
cacccgaggg gagagaaaag cuccauggag aggcuccuca cagaaaaaaa ugcugugauu 180
gaaagccugc aggaacaagu aaacaacgcc aaagagaaga uugugaggcu gaugucagcu 240
gagugcaccu augaccuccc agagggggcu gccccaccug ccucuucccc gaacaaggac 300
guccaggcgg uagccucggu ccacacccug gcagcugcuc aggggccuuc gggucaccuc 360
ucugacuuuc agaaugaucc uggcauggcu gcccgggauu cccagugcac uucagggccc 420
uccucauaug cacaaagccu ugaggggccu gggaaggacu ccagcuucuc cccagggaag 480
gaggagaaga uaucugacuc aaaagacuuu ucugaucauu uagacucagg uuguagccag 540
aagccaugga cugagcaaag ccugggucca gaaagaggag accaaguccc caugaacccc 600
agccagaguc uccuaccaga nagaggcggc ucagaucccc agagacagag gcaucuggag 660
aacucagagg agcccccaga gcggcgguca cggguuaguu caguaaucag ggagaaacuu 720
caggaggucu uacaagaucu gggccugggc ccugaggcuu cccucuccac cgcccccucu 780
ugucaucagc aaaccuggaa gaacagugcu gccuucagcc cccaaaagau gccccucucc 840
aaggagcucg gcuuuagccc uuacauggug aggagaaggc gggcagcuca gcgggcccgc 900
ucacacuuuc cuggcucugc acccucaucu guggggcauc gggcaaacag gacuguuccu 960
ggggcacaca gcaggcuaca ugugcagaau ggggacagcc ccagccuggc cccacaaacu 1020
acugauucca gaguacgaag accuucuucc aggaagccuu cacuaccuuc agauccucaa 1080
gacagaccag guacccugga gggcagcaaa caaagccaga cagagcccga gggggcuaga 1140
gggagcaaag cagccuuucu ucgccagccu ucugguucug gccgggcccc aaguccugcu 1200
gccccaugcc ucuccaaagc cucaccugac uugccugaac aguggcagcu guggccccca 1260
gugcccucag gcugugccuc ccugucuucu caacacagcu auuuugauac ugaguccagc 1320
agcucagaug aguucuucug ccgcugccac cggcccuacu gugaaaucug cuuccagagc 1380
ucuucugacu cuagugacag uggcacauca gacacugacc cugagccuac uggggggcug 1440
gcuuccuggg aaaagcugug ggcccgcucc aagccuauug ugaacuucaa agaugacuug 1500
aaacccacgc uggug 1515
<210> 25
<211> 2442
<212> DNA
<213> Homo sapien
<220>
<223> E533D GPR156 GAU mRNA
<220>
<221> variation
<222> (1548) .. (1548)
<223> n is a, g, u, or c
<400> 25
auggagccug aaauaaacug cucugaauug ugugacaguu uuccuggcca ggagcuggau 60
cggagacccc uucaugaucu cugcaagaca acaauuacau cuucccacca cagcaguaag 120
accaucucuu cauuaucucc uguccucuug gguauuguuu ggacuuuucu cagcugugga 180
cuucugcuga uacuuuucuu ucuugccuuu acaauucacu gcaggaagaa caggauugug 240
aagaugucca gucccaaucu gaacauugug accuuacugg gcaguugucu cacuuacagu 300
agcgcuuacc ucuuugggau ucaggauguu uuagugggga gcucaaugga aacucucauu 360
cagacaagac uguccaugcu gugcauuggg accucccuug uguuuggccc cauucuggga 420
aagagcuggc gacucuacaa gguguuuacc caaagggucc cggacaagag agugauuauc 480
aaagaccugc aguugcuggg guugguggca gcccuguuga uggcugaugu gauccugcuc 540
augacguggg ugcugacuga ucccauccag ugccuccaga uucucagugu caguaugacg 600
gugacaggga aagacguguc cugcacuucg accagcaccc acuucugugc uucccgguau 660
uccgauguuu ggauugcucu cauuugggga ugcaaggguc ugcuccugcu guauggugcc 720
uaccuggcug gccugacugg ccaugucagc uccccuccug ugaaucaguc cuuaaccauc 780
augguggggg ucaaccuccu uguacuggcu gcugggcugc uuuuuguagu caccagauac 840
uugcauuccu ggcccaaccu ggucuuugga cucacaucug gagggaucuu uguuuguaca 900
acuacaauca acugcuucau cuucauuccc cagcugaagc aauggaaggc auuugaagag 960
gaaaaccaaa caaucagacg cauggccaaa uauuucagca cucccaacaa aagcuuccau 1020
acccaguaug gugaggagga gaacugccac ccgaggggag agaaaagcuc cauggagagg 1080
cuccucacag aaaaaaaugc ugugauugaa agccugcagg aacaaguaaa caacgccaaa 1140
gagaagauug ugaggcugau gucagcugag ugcaccuaug accucccaga gggggcugcc 1200
ccaccugccu cuuccccgaa caaggacguc caggcgguag ccucggucca cacccuggca 1260
gcugcucagg ggccuucggg ucaccucucu gacuuucaga augauccugg cauggcugcc 1320
cgggauuccc agugcacuuc agggcccucc ucauaugcac aaagccuuga ggggccuggg 1380
aaggacucca gcuucucccc agggaaggag gagaagauau cugacucaaa agacuuuucu 1440
gaucauuuag acucagguug uagccagaag ccauggacug agcaaagccu ggguccagaa 1500
agaggagacc aaguccccau gaaccccagc cagagucucc uaccaganag aggcggcuca 1560
gauccccaga gacagaggca ucuggagaac ucagaggauc ccccagagcg gcggucacgg 1620
guuaguucag uaaucaggga gaaacuucag gaggucuuac aagaucuggg ccugggcccu 1680
gaggcuuccc ucuccaccgc ccccucuugu caucagcaaa ccuggaagaa cagugcugcc 1740
uucagccccc aaaagaugcc ccucuccaag gagcucggcu uuagcccuua cauggugagg 1800
agaaggcggg cagcucagcg ggcccgcuca cacuuuccug gcucugcacc cucaucugug 1860
gggcaucggg caaacaggac uguuccuggg gcacacagca ggcuacaugu gcagaauggg 1920
gacagcccca gccuggcccc acaaacuacu gauuccagag uacgaagacc uucuuccagg 1980
aagccuucac uaccuucaga uccucaagac agaccaggua cccuggaggg cagcaaacaa 2040
agccagacag agcccgaggg ggcuagaggg agcaaagcag ccuuucuucg ccagccuucu 2100
gguucuggcc gggccccaag uccugcugcc ccaugccucu ccaaagccuc accugacuug 2160
ccugaacagu ggcagcugug gcccccagug cccucaggcu gugccucccu gucuucucaa 2220
cacagcuauu uugauacuga guccagcagc ucagaugagu ucuucugccg cugccaccgg 2280
cccuacugug aaaucugcuu ccagagcucu ucugacucua gugacagugg cacaucagac 2340
acugacccug agccuacugg ggggcuggcu uccugggaaa agcugugggc ccgcuccaag 2400
ccuauuguga acuucaaaga ugacuugaaa cccacgcugg ug 2442
<210> 26
<211> 2442
<212> DNA
<213> Homo sapien
<220>
<223> E533D GPR156 GAC mRNA
<220>
<221> variation
<222> (1548) .. (1548)
<223> n is a, g, u, or c
<400> 26
auggagccug aaauaaacug cucugaauug ugugacaguu uuccuggcca ggagcuggau 60
cggagacccc uucaugaucu cugcaagaca acaauuacau cuucccacca cagcaguaag 120
accaucucuu cauuaucucc uguccucuug gguauuguuu ggacuuuucu cagcugugga 180
cuucugcuga uacuuuucuu ucuugccuuu acaauucacu gcaggaagaa caggauugug 240
aagaugucca gucccaaucu gaacauugug accuuacugg gcaguugucu cacuuacagu 300
agcgcuuacc ucuuugggau ucaggauguu uuagugggga gcucaaugga aacucucauu 360
cagacaagac uguccaugcu gugcauuggg accucccuug uguuuggccc cauucuggga 420
aagagcuggc gacucuacaa gguguuuacc caaagggucc cggacaagag agugauuauc 480
aaagaccugc aguugcuggg guugguggca gcccuguuga uggcugaugu gauccugcuc 540
augacguggg ugcugacuga ucccauccag ugccuccaga uucucagugu caguaugacg 600
gugacaggga aagacguguc cugcacuucg accagcaccc acuucugugc uucccgguau 660
uccgauguuu ggauugcucu cauuugggga ugcaaggguc ugcuccugcu guauggugcc 720
uaccuggcug gccugacugg ccaugucagc uccccuccug ugaaucaguc cuuaaccauc 780
augguggggg ucaaccuccu uguacuggcu gcugggcugc uuuuuguagu caccagauac 840
uugcauuccu ggcccaaccu ggucuuugga cucacaucug gagggaucuu uguuuguaca 900
acuacaauca acugcuucau cuucauuccc cagcugaagc aauggaaggc auuugaagag 960
gaaaaccaaa caaucagacg cauggccaaa uauuucagca cucccaacaa aagcuuccau 1020
acccaguaug gugaggagga gaacugccac ccgaggggag agaaaagcuc cauggagagg 1080
cuccucacag aaaaaaaugc ugugauugaa agccugcagg aacaaguaaa caacgccaaa 1140
gagaagauug ugaggcugau gucagcugag ugcaccuaug accucccaga gggggcugcc 1200
ccaccugccu cuuccccgaa caaggacguc caggcgguag ccucggucca cacccuggca 1260
gcugcucagg ggccuucggg ucaccucucu gacuuucaga augauccugg cauggcugcc 1320
cgggauuccc agugcacuuc agggcccucc ucauaugcac aaagccuuga ggggccuggg 1380
aaggacucca gcuucucccc agggaaggag gagaagauau cugacucaaa agacuuuucu 1440
gaucauuuag acucagguug uagccagaag ccauggacug agcaaagccu ggguccagaa 1500
agaggagacc aaguccccau gaaccccagc cagagucucc uaccaganag aggcggcuca 1560
gauccccaga gacagaggca ucuggagaac ucagaggacc ccccagagcg gcggucacgg 1620
guuaguucag uaaucaggga gaaacuucag gaggucuuac aagaucuggg ccugggcccu 1680
gaggcuuccc ucuccaccgc ccccucuugu caucagcaaa ccuggaagaa cagugcugcc 1740
uucagccccc aaaagaugcc ccucuccaag gagcucggcu uuagcccuua cauggugagg 1800
agaaggcggg cagcucagcg ggcccgcuca cacuuuccug gcucugcacc cucaucugug 1860
gggcaucggg caaacaggac uguuccuggg gcacacagca ggcuacaugu gcagaauggg 1920
gacagcccca gccuggcccc acaaacuacu gauuccagag uacgaagacc uucuuccagg 1980
aagccuucac uaccuucaga uccucaagac agaccaggua cccuggaggg cagcaaacaa 2040
agccagacag agcccgaggg ggcuagaggg agcaaagcag ccuuucuucg ccagccuucu 2100
gguucuggcc gggccccaag uccugcugcc ccaugccucu ccaaagccuc accugacuug 2160
ccugaacagu ggcagcugug gcccccagug cccucaggcu gugccucccu gucuucucaa 2220
cacagcuauu uugauacuga guccagcagc ucagaugagu ucuucugccg cugccaccgg 2280
cccuacugug aaaucugcuu ccagagcucu ucugacucua gugacagugg cacaucagac 2340
acugacccug agccuacugg ggggcuggcu uccugggaaa agcugugggc ccgcuccaag 2400
ccuauuguga acuucaaaga ugacuugaaa cccacgcugg ug 2442
<210> 27
<211> 2430
<212> DNA
<213> Homo sapien
<220>
<223> E529D GPR156 GAU mRNA
<220>
<221> variation
<222> (1536) .. (1536)
<223> n is a, g, u, or c
<400> 27
auggagccug aaauaaacug cucugaauug ugugacaguu uuccuggcca ggagcuggau 60
cggagacccc uucaugaucu cugcaagaca acaauuacau cuucccacca cagcaguaag 120
accaucucuu cauuaucucc uguccucuug gguauuguuu ggacuuuucu cagcugugga 180
cuucugcuga uacuuuucuu ucuugccuuu acaauucacu gcaggaagaa caggauugug 240
aagaugucca gucccaaucu gaacauugug accuuacugg gcaguugucu cacuuacagu 300
agcgcuuacc ucuuugggau ucaggauguu uuagugggga gcucaaugga aacucucauu 360
cagacaagac uguccaugcu gugcauuggg accucccuug uguuuggccc cauucuggga 420
aagagcuggc gacucuacaa gguguuuacc caaagggucc cggacaagag agugauuauc 480
aaagaccugc aguugcuggg guugguggca gcccuguuga uggcugaugu gauccugcuc 540
augacguggg ugcugacuga ucccauccag ugccuccaga uucucagugu gacagggaaa 600
gacguguccu gcacuucgac cagcacccac uucugugcuu cccgguauuc cgauguuugg 660
auugcucuca uuuggggaug caagggucug cuccugcugu auggugccua ccuggcuggc 720
cugacuggcc augucagcuc cccuccugug aaucaguccu uaaccaucau gguggggguc 780
aaccuccuug uacuggcugc ugggcugcuu uuuguaguca ccagauacuu gcauuccugg 840
cccaaccugg ucuuuggacu cacaucugga gggaucuuug uuuguacaac uacaaucaac 900
ugcuucaucu ucauucccca gcugaagcaa uggaaggcau uugaagagga aaaccaaaca 960
aucagacgca uggccaaaua uuucagcacu cccaacaaaa gcuuccauac ccaguauggu 1020
gaggaggaga acugccaccc gaggggagag aaaagcucca uggagaggcu ccucacagaa 1080
aaaaaugcug ugauugaaag ccugcaggaa caaguaaaca acgccaaaga gaagauugug 1140
aggcugaugu cagcugagug caccuaugac cucccagagg gggcugcccc accugccucu 1200
uccccgaaca aggacgucca ggcgguagcc ucgguccaca cccuggcagc ugcucagggg 1260
ccuucggguc accucucuga cuuucagaau gauccuggca uggcugcccg ggauucccag 1320
ugcacuucag ggcccuccuc auaugcacaa agccuugagg ggccugggaa ggacuccagc 1380
uucuccccag ggaaggagga gaagauaucu gacucaaaag acuuuucuga ucauuuagac 1440
ucagguugua gccagaagcc auggacugag caaagccugg guccagaaag aggagaccaa 1500
guccccauga accccagcca gagucuccua ccaganagag gcggcucaga uccccagaga 1560
cagaggcauc uggagaacuc agaggauccc ccagagcggc ggucacgggu uaguucagua 1620
aucagggaga aacuucagga ggucuuacaa gaucugggcc ugggcccuga ggcuucccuc 1680
uccaccgccc ccucuuguca ucagcaaacc uggaagaaca gugcugccuu cagcccccaa 1740
aagaugcccc ucuccaagga gcucggcuuu agcccuuaca uggugaggag aaggcgggca 1800
gcucagcggg cccgcucaca cuuuccuggc ucugcacccu caucuguggg gcaucgggca 1860
aacaggacug uuccuggggc acacagcagg cuacaugugc agaaugggga cagccccagc 1920
cuggccccac aaacuacuga uuccagagua cgaagaccuu cuuccaggaa gccuucacua 1980
ccuucagauc cucaagacag accagguacc cuggagggca gcaaacaaag ccagacagag 2040
cccgaggggg cuagagggag caaagcagcc uuucuucgcc agccuucugg uucuggccgg 2100
gccccaaguc cugcugcccc augccucucc aaagccucac cugacuugcc ugaacagugg 2160
cagcuguggc ccccagugcc cucaggcugu gccucccugu cuucucaaca cagcuauuuu 2220
gauacugagu ccagcagcuc agaugaguuc uucugccgcu gccaccggcc cuacugugaa 2280
aucugcuucc agagcucuuc ugacucuagu gacaguggca caucagacac ugacccugag 2340
ccuacugggg ggcuggcuuc cugggaaaag cugugggccc gcuccaagcc uauugugaac 2400
uucaaagaug acuugaaacc cacgcuggug 2430
<210> 28
<211> 2430
<212> DNA
<213> Homo sapien
<220>
<223> E529D GPR156 GAC mRNA
<220>
<221> variation
<222> (1536) .. (1536)
<223> n is a, g, u, or c
<400> 28
auggagccug aaauaaacug cucugaauug ugugacaguu uuccuggcca ggagcuggau 60
cggagacccc uucaugaucu cugcaagaca acaauuacau cuucccacca cagcaguaag 120
accaucucuu cauuaucucc uguccucuug gguauuguuu ggacuuuucu cagcugugga 180
cuucugcuga uacuuuucuu ucuugccuuu acaauucacu gcaggaagaa caggauugug 240
aagaugucca gucccaaucu gaacauugug accuuacugg gcaguugucu cacuuacagu 300
agcgcuuacc ucuuugggau ucaggauguu uuagugggga gcucaaugga aacucucauu 360
cagacaagac uguccaugcu gugcauuggg accucccuug uguuuggccc cauucuggga 420
aagagcuggc gacucuacaa gguguuuacc caaagggucc cggacaagag agugauuauc 480
aaagaccugc aguugcuggg guugguggca gcccuguuga uggcugaugu gauccugcuc 540
augacguggg ugcugacuga ucccauccag ugccuccaga uucucagugu gacagggaaa 600
gacguguccu gcacuucgac cagcacccac uucugugcuu cccgguauuc cgauguuugg 660
auugcucuca uuuggggaug caagggucug cuccugcugu auggugccua ccuggcuggc 720
cugacuggcc augucagcuc cccuccugug aaucaguccu uaaccaucau gguggggguc 780
aaccuccuug uacuggcugc ugggcugcuu uuuguaguca ccagauacuu gcauuccugg 840
cccaaccugg ucuuuggacu cacaucugga gggaucuuug uuuguacaac uacaaucaac 900
ugcuucaucu ucauucccca gcugaagcaa uggaaggcau uugaagagga aaaccaaaca 960
aucagacgca uggccaaaua uuucagcacu cccaacaaaa gcuuccauac ccaguauggu 1020
gaggaggaga acugccaccc gaggggagag aaaagcucca uggagaggcu ccucacagaa 1080
aaaaaugcug ugauugaaag ccugcaggaa caaguaaaca acgccaaaga gaagauugug 1140
aggcugaugu cagcugagug caccuaugac cucccagagg gggcugcccc accugccucu 1200
uccccgaaca aggacgucca ggcgguagcc ucgguccaca cccuggcagc ugcucagggg 1260
ccuucggguc accucucuga cuuucagaau gauccuggca uggcugcccg ggauucccag 1320
ugcacuucag ggcccuccuc auaugcacaa agccuugagg ggccugggaa ggacuccagc 1380
uucuccccag ggaaggagga gaagauaucu gacucaaaag acuuuucuga ucauuuagac 1440
ucagguugua gccagaagcc auggacugag caaagccugg guccagaaag aggagaccaa 1500
guccccauga accccagcca gagucuccua ccaganagag gcggcucaga uccccagaga 1560
cagaggcauc uggagaacuc agaggacccc ccagagcggc ggucacgggu uaguucagua 1620
aucagggaga aacuucagga ggucuuacaa gaucugggcc ugggcccuga ggcuucccuc 1680
uccaccgccc ccucuuguca ucagcaaacc uggaagaaca gugcugccuu cagcccccaa 1740
aagaugcccc ucuccaagga gcucggcuuu agcccuuaca uggugaggag aaggcgggca 1800
gcucagcggg cccgcucaca cuuuccuggc ucugcacccu caucuguggg gcaucgggca 1860
aacaggacug uuccuggggc acacagcagg cuacaugugc agaaugggga cagccccagc 1920
cuggccccac aaacuacuga uuccagagua cgaagaccuu cuuccaggaa gccuucacua 1980
ccuucagauc cucaagacag accagguacc cuggagggca gcaaacaaag ccagacagag 2040
cccgaggggg cuagagggag caaagcagcc uuucuucgcc agccuucugg uucuggccgg 2100
gccccaaguc cugcugcccc augccucucc aaagccucac cugacuugcc ugaacagugg 2160
cagcuguggc ccccagugcc cucaggcugu gccucccugu cuucucaaca cagcuauuuu 2220
gauacugagu ccagcagcuc agaugaguuc uucugccgcu gccaccggcc cuacugugaa 2280
aucugcuucc agagcucuuc ugacucuagu gacaguggca caucagacac ugacccugag 2340
ccuacugggg ggcuggcuuc cugggaaaag cugugggccc gcuccaagcc uauugugaac 2400
uucaaagaug acuugaaacc cacgcuggug 2430
<210> 29
<211> 1515
<212> DNA
<213> Homo sapien
<220>
<223> E533D GPR156 GAU mRNA, fragment 310-814
<220>
<221> variation
<222> (621) .. (621)
<223> n is a, g, u, or c
<400> 29
ccccagcuga agcaauggaa ggcauuugaa gaggaaaacc aaacaaucag acgcauggcc 60
aaauauuuca gcacucccaa caaaagcuuc cauacccagu auggugagga ggagaacugc 120
cacccgaggg gagagaaaag cuccauggag aggcuccuca cagaaaaaaa ugcugugauu 180
gaaagccugc aggaacaagu aaacaacgcc aaagagaaga uugugaggcu gaugucagcu 240
gagugcaccu augaccuccc agagggggcu gccccaccug ccucuucccc gaacaaggac 300
guccaggcgg uagccucggu ccacacccug gcagcugcuc aggggccuuc gggucaccuc 360
ucugacuuuc agaaugaucc uggcauggcu gcccgggauu cccagugcac uucagggccc 420
uccucauaug cacaaagccu ugaggggccu gggaaggacu ccagcuucuc cccagggaag 480
gaggagaaga uaucugacuc aaaagacuuu ucugaucauu uagacucagg uuguagccag 540
aagccaugga cugagcaaag ccugggucca gaaagaggag accaaguccc caugaacccc 600
agccagaguc uccuaccaga nagaggcggc ucagaucccc agagacagag gcaucuggag 660
aacucagagg aucccccaga gcggcgguca cggguuaguu caguaaucag ggagaaacuu 720
caggaggucu uacaagaucu gggccugggc ccugaggcuu cccucuccac cgcccccucu 780
ugucaucagc aaaccuggaa gaacagugcu gccuucagcc cccaaaagau gccccucucc 840
aaggagcucg gcuuuagccc uuacauggug aggagaaggc gggcagcuca gcgggcccgc 900
ucacacuuuc cuggcucugc acccucaucu guggggcauc gggcaaacag gacuguuccu 960
ggggcacaca gcaggcuaca ugugcagaau ggggacagcc ccagccuggc cccacaaacu 1020
acugauucca gaguacgaag accuucuucc aggaagccuu cacuaccuuc agauccucaa 1080
gacagaccag guacccugga gggcagcaaa caaagccaga cagagcccga gggggcuaga 1140
gggagcaaag cagccuuucu ucgccagccu ucugguucug gccgggcccc aaguccugcu 1200
gccccaugcc ucuccaaagc cucaccugac uugccugaac aguggcagcu guggccccca 1260
gugcccucag gcugugccuc ccugucuucu caacacagcu auuuugauac ugaguccagc 1320
agcucagaug aguucuucug ccgcugccac cggcccuacu gugaaaucug cuuccagagc 1380
ucuucugacu cuagugacag uggcacauca gacacugacc cugagccuac uggggggcug 1440
gcuuccuggg aaaagcugug ggcccgcucc aagccuauug ugaacuucaa agaugacuug 1500
aaacccacgc uggug 1515
<210> 30
<211> 1515
<212> DNA
<213> Artificial Sequence
<220>
<223> E533D GPR156 GAC mRNA, fragment 310-814
<220>
<221> variation
<222> (621) .. (621)
<223> n is a, g, u, or c
<400> 30
ccccagcuga agcaauggaa ggcauuugaa gaggaaaacc aaacaaucag acgcauggcc 60
aaauauuuca gcacucccaa caaaagcuuc cauacccagu auggugagga ggagaacugc 120
cacccgaggg gagagaaaag cuccauggag aggcuccuca cagaaaaaaa ugcugugauu 180
gaaagccugc aggaacaagu aaacaacgcc aaagagaaga uugugaggcu gaugucagcu 240
gagugcaccu augaccuccc agagggggcu gccccaccug ccucuucccc gaacaaggac 300
guccaggcgg uagccucggu ccacacccug gcagcugcuc aggggccuuc gggucaccuc 360
ucugacuuuc agaaugaucc uggcauggcu gcccgggauu cccagugcac uucagggccc 420
uccucauaug cacaaagccu ugaggggccu gggaaggacu ccagcuucuc cccagggaag 480
gaggagaaga uaucugacuc aaaagacuuu ucugaucauu uagacucagg uuguagccag 540
aagccaugga cugagcaaag ccugggucca gaaagaggag accaaguccc caugaacccc 600
agccagaguc uccuaccaga nagaggcggc ucagaucccc agagacagag gcaucuggag 660
aacucagagg accccccaga gcggcgguca cggguuaguu caguaaucag ggagaaacuu 720
caggaggucu uacaagaucu gggccugggc ccugaggcuu cccucuccac cgcccccucu 780
ugucaucagc aaaccuggaa gaacagugcu gccuucagcc cccaaaagau gccccucucc 840
aaggagcucg gcuuuagccc uuacauggug aggagaaggc gggcagcuca gcgggcccgc 900
ucacacuuuc cuggcucugc acccucaucu guggggcauc gggcaaacag gacuguuccu 960
ggggcacaca gcaggcuaca ugugcagaau ggggacagcc ccagccuggc cccacaaacu 1020
acugauucca gaguacgaag accuucuucc aggaagccuu cacuaccuuc agauccucaa 1080
gacagaccag guacccugga gggcagcaaa caaagccaga cagagcccga gggggcuaga 1140
gggagcaaag cagccuuucu ucgccagccu ucugguucug gccgggcccc aaguccugcu 1200
gccccaugcc ucuccaaagc cucaccugac uugccugaac aguggcagcu guggccccca 1260
gugcccucag gcugugccuc ccugucuucu caacacagcu auuuugauac ugaguccagc 1320
agcucagaug aguucuucug ccgcugccac cggcccuacu gugaaaucug cuuccagagc 1380
ucuucugacu cuagugacag uggcacauca gacacugacc cugagccuac uggggggcug 1440
gcuuccuggg aaaagcugug ggcccgcucc aagccuauug ugaacuucaa agaugacuug 1500
aaacccacgc uggug 1515
<210> 31
<211> 9
<212> DNA
<213> Artificial Sequence
<220>
<223> GPR156 forward primer
<400> 31
tctccccag 9
<210> 32
<211> 9
<212> DNA
<213> Artificial Sequence
<220>
<223> GPR156 forward primer
<400> 32
agaggggtc 9
<210> 33
<211> 9
<212> DNA
<213> Artificial Sequence
<220>
<223> GPR156 forward primer
<400> 33
tctccccat 9
<210> 34
<211> 8
<212> DNA
<213> Artificial Sequence
<220>
<223> GPR156 forward primer
<400> 34
agagggga 8
<210> 35
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> GPR156 forward primer
<400> 35
ccagagtctc ctaccagata g 21
<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> GPR156 reverse primer
<400> 36
agaaggctgg cgaagaaagg 20
<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> GPR156 forward primer
<400> 37
caacgccaaa gagaagattg 20
<210> 38
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> GPR156 reverse primer
<400> 38
cttccaggtt tgctgatgac a 21
<210> 39
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> GPR156 forward primer
<400> 39
aagatatctg actcaaaaga c 21
<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> GPR156 reverse primer
<400> 40
agagccagga aagtgtgagc 20
<210> 41
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> GPR156 forward primer
<400> 41
tttcagaatg atcctggcat g 21
<210> 42
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> GPR156 reverse primer
<400> 42
actgttcttc caggtttgct g 21
Claims (84)
- 인간 G 단백질-연계된 수용체 156 (GPR156) 단백질을 인코딩하는 핵산 서열, 또는 상기 핵산 서열의 보체를 포함하는 단리된 핵산 분자로서,
상기 단백질은 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 것을 특징으로 하는 단리된 핵산 분자. - 제1항에 있어서,
핵산 분자는 DNA를 포함하는 것을 특징으로 하는 단리된 핵산 분자. - 제2항에 있어서,
핵산 분자는 cDNA인 것을 특징으로 하는 단리된 핵산 분자. - 제1항에 있어서,
핵산 분자는 RNA를 포함하는 것을 특징으로 하는 단리된 핵산 분자. - 제1항 내지 제4항 중 어느 한 항에 있어서,
핵산 서열은 DNA를 포함하고, 아스파르트산이 코돈 GAT 또는 GAC에 의해 인코딩되거나, 또는 핵산 서열은 RNA를 포함하고, 아스파르트산이 코돈 GAU 또는 GAC에 의해 인코딩되는 것을 특징으로 하는 단리된 핵산 분자. - 제1항 내지 제4항 중 어느 한 항에 있어서,
아스파르트산은 코돈 GAT에 의해 인코딩되는 것을 특징으로 하는 단리된 핵산 분자. - 제1항 내지 제4항 중 어느 한 항에 있어서,
GPR156 단백질은 서열 번호:4의 아미노산 서열을 포함하고, 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 것을 특징으로 하는 단리된 핵산 분자. - 제1항 내지 제4항 중 어느 한 항에 따른 단리된 핵산 분자를 포함하는 벡터.
- 제8항에 있어서,
벡터는 플라스미드인 것을 특징으로 하는 벡터. - 제8항에 있어서,
벡터는 바이러스인 것을 특징으로 하는 벡터. - 제1항 내지 제4항 중 어느 한 항에 따른 단리된 핵산 분자를 포함하는 숙주 세포.
- 제8항에 따른 벡터를 포함하는 숙주 세포.
- 제11항에 있어서,
핵산 서열은 숙주 세포에서 활성인 프로모터에 작동가능하게 연결된 것을 특징으로 하는 숙주 세포. - 제13항에 있어서,
프로모터는 외인성 프로모터인 것을 특징으로 하는 숙주 세포. - 제13항에 있어서,
프로모터는 유도성 프로모터인 것을 특징으로 하는 숙주 세포. - 제12항에 있어서,
숙주 세포는 포유류 세포인 것을 특징으로 하는 숙주 세포. - 인간 GPR156 단백질의 적어도 일부를 인코딩하는 핵산 서열을 포함하는 cDNA로서, 여기서 상기 일부는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 것을 특징으로 하는 cDNA.
- 제17항에 있어서,
cDNA는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 전장 인간 GPR156 단백질을 인코딩하는 것을 특징으로 하는 cDNA. - 제17항 또는 제18항에 있어서,
아스파르트산은 코돈 GAT에 의해 인코딩되는 것을 특징으로 하는 cDNA. - 제17항 또는 제18항에 있어서,
cDNA는 서열 번호:16의 핵산 서열을 포함하고, 여기서 상기 cDNA는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 GPR156 단백질을 인코딩하는 것을 특징으로 하는 cDNA. - 제17항 또는 제18항에 있어서,
아스파르트산은 코돈 GAC에 의해 인코딩되는 것을 특징으로 하는 cDNA. - 제17항 또는 제18항에 있어서,
cDNA는 서열 번호:17의 핵산 서열을 포함하고, 여기서 상기 cDNA는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 GPR156 단백질을 인코딩하는 것을 특징으로 하는 cDNA. - 제17항 또는 제18항에 따른 cDNA를 포함하는 벡터.
- 제23항에 있어서,
벡터는 플라스미드인 것을 특징으로 하는 벡터. - 제23항에 있어서,
벡터는 바이러스인 것을 특징으로 하는 벡터. - 제17항 또는 제18항에 따른 cDNA를 포함하는 숙주 세포.
- 제23항에 따른 벡터를 포함하는 숙주 세포.
- 제26항에 있어서,
cDNA는 숙주 세포에서 활성인 프로모터에 작동가능하게 연결된 것을 특징으로 하는 숙주 세포. - 제28항에 있어서,
프로모터는 외인성 프로모터인 것을 특징으로 하는 숙주 세포. - 제28항에 있어서,
프로모터는 유도성 프로모터인 것을 특징으로 하는 숙주 세포. - 제26항에 있어서,
숙주 세포는 포유류 세포인 것을 특징으로 하는 숙주 세포. - 인간 G 단백질-연계된 수용체 156 (GPR156) 단백질의 적어도 일부를 포함하는 단리된 또는 재조합 폴리펩티드로서, 상기 일부는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 것을 특징으로 하는 단리된 또는 재조합 폴리펩티드.
- 제32항에 있어서,
폴리펩티드는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 전장 GPR156 단백질을 포함하는 것을 특징으로 하는 단리된 또는 재조합 폴리펩티드. - 제32항 또는 제33항에 있어서,
폴리펩티드는 서열 번호:4의 아미노산 서열을 포함하고, 여기서 상기 폴리펩티드는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 것을 특징으로 하는 단리된 또는 재조합 폴리펩티드. - 제32항 또는 제33항에 있어서,
폴리펩티드는 이종성 폴리펩티드에 융합된 것을 특징으로 하는 단리된 또는 재조합 폴리펩티드. - 제35항에 있어서,
이종성 폴리펩티드는 펩티드 정제 태그, 형광 단백질, 또는 펩티드 정제 태그 및 형광 단백질 둘 모두를 포함하는 것을 특징으로 하는 단리된 또는 재조합 폴리펩티드. - 제32항 또는 제33항에 있어서,
폴리펩티드는 검출가능한 표지에 연결된 것을 특징으로 하는 단리된 또는 재조합 폴리펩티드. - 제37항에 있어서,
검출가능한 표지는 형광 표지 또는 방사성 표지인 것을 특징으로 하는 단리된 또는 재조합 폴리펩티드. - 제32항 또는 제33항에 따른 단리된 또는 재조합 폴리펩티드 및 담체를 포함하는 조성물.
- 적어도 15개 뉴클레오티드를 포함하는 핵산 서열을 포함하는 프로브 또는 프라이머로서, 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 인간 G 단백질-연계된 수용체 156 (GPR156) 단백질을 인코딩하는 핵산 서열에 특이적으로 혼성화하거나, 또는 인간 GPR156 단백질을 인코딩하는 핵산 서열의 보체에 특이적으로 혼성화하는 것을 특징으로 하는 프로브 또는 프라이머.
- 제40항에 있어서,
프로브 또는 프라이머는 DNA를 포함하는 것을 특징으로 하는 프로브 또는 프라이머. - 제40항에 있어서,
프로브 또는 프라이머는 RNA를 포함하는 것을 특징으로 하는 프로브 또는 프라이머. - 제40항 내지 제42항 중 어느 한 항에 있어서,
아스파르트산은 코돈 GAT에 의해 인코딩되는 것을 특징으로 하는 프로브 또는 프라이머. - 제40항 내지 제42항 중 어느 한 항에 있어서,
아스파르트산은 코돈 GAC에 의해 인코딩되는 것을 특징으로 하는 프로브 또는 프라이머. - 제40항 내지 제42항 중 어느 한 항에 있어서,
프로브 또는 프라이머는 엄격한 조건 하에, 인간 GPR156 단백질을 인코딩하는 핵산 서열, 또는 이의 보체에 특이적으로 혼성화하는 것을 특징으로 하는 프로브 또는 프라이머. - 제40항 내지 제42항 중 어느 한 항에 있어서,
프로브 또는 프라이머는 표지를 포함하는 것을 특징으로 하는 프로브 또는 프라이머. - 제46항에 있어서,
표지는 형광 표지, 방사성 표지, 또는 비오틴인 것을 특징으로 하는 프로브 또는 프라이머. - 제40항 내지 제42항 중 어느 한 항에 따른 프로브가 부착되는 기질을 포함하는 지지체.
- 제48항에 있어서,
지지체는 마이크로어레이인 것을 특징으로 하는 지지체. - GPR156 단백질을 인코딩하는 핵산 서열에 상보적인 핵산 서열을 포함하는 대립유전자-특이적 프로브 또는 프라이머로서, 상기 대립유전자-특이적 프로브 또는 프라이머는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 핵산 코돈에 상보적인 핵산 서열을 포함하는 것을 특징으로 하는 대립유전자-특이적 프로브 또는 프라이머.
- 제50항에 있어서,
아스파르트산은 코돈 GAT에 의해 인코딩되는 것을 특징으로 하는 대립유전자-특이적 프라이머. - 제50항에 있어서,
아스파르트산은 코돈 GAC에 의해 인코딩되는 것을 특징으로 하는 대립유전자-특이적 프라이머. - 단극성 우울증을 앓거나 또는 단극성 우울증이 발달할 위험에 처해 있는 인간 개체를 확인하기 위한 방법으로서, 상기 방법은 개체로부터 획득된 표본에서
(i) GPR156 단백질 내에서 E533D 변이; 및
(ii) GPR156 단백질 내에서 E533D 변이를 인코딩하는 핵산 분자 중 적어도 하나의 존재 또는 부재를 결정하는 것을 포함하고; 여기서 GPR156 단백질 내에서 상기 E533D 변이 및/또는 상기 E533D 변이를 인코딩하는 상기 핵산 분자의 존재는 상기 개체가 단극성 우울증을 앓거나 또는 단극성 우울증이 발달할 위험에 처해 있다는 것을 지시하는 것을 특징으로 하는 방법. - 제53항에 있어서,
단극성 우울증의 하나 이상의 증상의 존재는 개체가 단극성 우울증을 앓는다는 것을 지시하는 것을 특징으로 하는 방법. - 제53항 또는 제54항에 있어서,
상기 방법은 시험관내 방법인 것을 특징으로 하는 방법. - 제53항 또는 제54항에 있어서,
결정하는 단계는 GPR156 단백질을 인코딩하는 핵산 분자의 적어도 일부를 염기서열결정하는 것을 포함하고, 여기서 염기서열결정된 핵산 분자는 서열 번호:4에 따른 위치 533에 상응하는 위치를 포함하는 아미노산 서열을 인코딩하는 것을 특징으로 하는 방법. - 제53항 또는 제54항에 있어서,
결정하는 단계는 전체 GPR156 단백질을 인코딩하는 핵산 분자를 염기서열결정하는 것을 포함하는 것을 특징으로 하는 방법. - 제53항 또는 제54항에 있어서,
결정하는 단계는 다음을 포함하는 것을 특징으로 하는 방법:
GPR156 단백질을 인코딩하는 핵산 분자의 적어도 일부를 증폭하고, 여기서 증폭된 핵산 분자는 서열 번호:4에 따른 위치 533에 상응하는 위치를 포함하는 아미노산 서열을 인코딩하고;
상기 핵산 분자를 검출가능한 표지로 표지화하고;
상기 표지화된 핵산을 프로브를 포함하는 지지체와 접촉시키고, 여기서 상기 프로브는 엄격한 조건 하에, 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 핵산 서열에 혼성화하는 핵산 서열을 포함하고; 그리고
상기 검출가능한 표지를 검출함. - 제58항에 있어서,
핵산 분자는 mRNA이고, 결정하는 단계는 증폭하는 단계에 앞서 mRNA를 cDNA로 역전사하는 것을 더욱 포함하는 것을 특징으로 하는 방법. - 제53항 또는 제54항에 있어서,
결정하는 단계는 다음을 포함하는 것을 특징으로 하는 방법:
핵산 분자를 검출가능한 표지를 포함하는 프로브와 접촉시키고, 여기서 상기 프로브는 엄격한 조건 하에, 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 아미노산 서열을 인코딩하는 핵산 서열에 혼성화하는 핵산 서열을 포함하고, 그리고
상기 검출가능한 표지를 검출함. - 제60항에 있어서,
핵산 분자는 인간 개체로부터 획득된 세포 내에 존재하는 것을 특징으로 하는 방법. - 제53항 또는 제54항에 있어서,
GPR156 단백질 내에서 E533D 변이는 코돈 GAT에 의해 인코딩되는 것을 특징으로 하는 방법. - 제53항 또는 제54항에 있어서,
GPR156 단백질 내에서 E533D 변이는 코돈 GAC에 의해 인코딩되는 것을 특징으로 하는 방법. - 인간 개체에서 단극성 우울증의 위험을 검출하기 위한 방법으로서, 다음을 포함하는 것을 특징으로 하는 방법:
인간 개체로부터 획득된 GPR156 단백질을 인코딩하는 핵산 분자에서 변경을 검출하고, 여기서 상기 변경은 GPR156 단백질에서 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩함. - 제64항에 있어서,
검출하는 단계는 GPR156 단백질을 인코딩하는 핵산 분자의 적어도 일부를 염기서열결정하는 것을 포함하고, 여기서 염기서열결정된 핵산 분자는 서열 번호:4에 따른 위치 533에 상응하는 위치를 포함하는 아미노산 서열을 인코딩하는 것을 특징으로 하는 방법. - 제64항 또는 제65항에 있어서,
검출하는 단계는 전체 핵산 분자를 염기서열결정하는 것을 포함하는 것을 특징으로 하는 방법. - 제64항에 있어서,
검출하는 단계는 다음을 포함하는 것을 특징으로 하는 방법:
GPR156 단백질을 인코딩하는 핵산 분자의 적어도 일부를 증폭하고, 여기서 증폭된 핵산 분자는 서열 번호:4에 따른 위치 533에 상응하는 위치를 포함하는 아미노산 서열을 인코딩하고;
상기 핵산 분자를 검출가능한 표지로 표지화하고;
상기 표지화된 핵산을 프로브를 포함하는 지지체와 접촉시키고, 여기서 상기 프로브는 엄격한 조건 하에, 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 인코딩하는 핵산 서열에 혼성화하는 핵산 서열을 포함하고; 그리고
상기 검출가능한 표지를 검출함. - 제67항에 있어서,
핵산 분자는 mRNA이고, 상기 방법은 증폭하는 단계에 앞서 mRNA를 cDNA로 역전사하는 것을 더욱 포함하는 것을 특징으로 하는 방법. - 제64항에 있어서,
검출하는 단계는 다음을 포함하는 것을 특징으로 하는 방법:
핵산 분자를 검출가능한 표지를 포함하는 프로브와 접촉시키고, 여기서 상기 프로브는 엄격한 조건 하에, 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 포함하는 아미노산 서열을 인코딩하는 핵산 서열에 혼성화하는 핵산 서열을 포함하고, 그리고
상기 검출가능한 표지를 검출함. - 제69항에 있어서,
핵산 분자는 인간 개체로부터 획득된 세포 내에 존재하는 것을 특징으로 하는 방법. - 제64항 또는 제65항에 있어서,
변경은 서열 번호:4에 따른 위치 533에 상응하는 위치를 인코딩하는 코돈의 서열을 GAT로 변화시키는 것을 특징으로 하는 방법. - 제64항 또는 제65항에 있어서,
변경은 서열 번호:4에 따른 위치 533에 상응하는 위치를 인코딩하는 코돈의 서열을 GAC로 변화시키는 것을 특징으로 하는 방법. - 제64항 또는 제65항에 있어서,
상기 방법은 변경이 개체에서 검출되고, 상기 개체가 단극성 우울증을 앓는 것으로 진단될 때, 상기 개체를 항우울제로 치료하는 것을 더욱 포함하는 것을 특징으로 하는 방법. - 제73항에 있어서,
항우울제는 선택적 세로토닌 재흡수 저해제, 세로토닌-노르에피네프린 재흡수 저해제, 또는 노르에피네프린 재흡수 저해제인 것을 특징으로 하는 방법. - 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 삭제
- 제53항 또는 제54항에 있어서,
E533D 변이는 서열 번호:4에 따른 위치 533에 상응하는 위치에서 아스파르트산을 유발하는 변이를 지칭하는 것을 특징으로 하는 방법. - 삭제
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| DK3401400T3 (da) | 2012-05-25 | 2019-06-03 | Univ California | Fremgangsmåder og sammensætninger til rna-styret mål-dna-modifikation og til rna-styret transskriptionsmodulering |
| JP6620018B2 (ja) | 2012-12-06 | 2019-12-11 | シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニーＳｉｇｍａ−Ａｌｄｒｉｃｈ Ｃｏ．， ＬＬＣ | Ｃｒｉｓｐｒに基づくゲノム修飾および制御 |
| JP2019527229A (ja) | 2016-07-28 | 2019-09-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｇｐｒ１５６変異体及びその使用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2006513702A (ja) * | 2002-09-09 | 2006-04-27 | ヌラ インコーポレーティッド | Ｇタンパク質共役受容体およびその使用 |
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| Title |
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| Biochimica et Biophysica Acta (BBA) - Biomembranes 1768(4):976-993(2007.03.28.) |
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| KR20240027874A (ko) | 2024-03-04 |
| US20190202891A1 (en) | 2019-07-04 |
| AU2017302611A1 (en) | 2019-03-14 |
| US10266582B2 (en) | 2019-04-23 |
| US20220073589A1 (en) | 2022-03-10 |
| IL264473A (en) | 2019-02-28 |
| DK3491014T3 (da) | 2023-05-30 |
| SG11201900738YA (en) | 2019-02-27 |
| CA3032124A1 (en) | 2018-02-01 |
| JP2023071704A (ja) | 2023-05-23 |
| CN109563516B (zh) | 2023-10-27 |
| WO2018022967A1 (en) | 2018-02-01 |
| AU2017302611B2 (en) | 2021-12-09 |
| MX2019001084A (es) | 2019-06-10 |
| EP4230648A2 (en) | 2023-08-23 |
| CN109563516A (zh) | 2019-04-02 |
| US20180030114A1 (en) | 2018-02-01 |
| EP4230648A3 (en) | 2023-10-18 |
| EP3491014B1 (en) | 2023-04-05 |
| US20200231651A1 (en) | 2020-07-23 |
| EP3491014A1 (en) | 2019-06-05 |
| KR20190034532A (ko) | 2019-04-02 |
| JP2019527229A (ja) | 2019-09-26 |
| US11155598B2 (en) | 2021-10-26 |
| US10562953B2 (en) | 2020-02-18 |
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