CN113853437A - 腺相关病毒载体用于在内耳中的毛细胞和支持细胞中校正基因缺陷/表达蛋白质的用途 - Google Patents

腺相关病毒载体用于在内耳中的毛细胞和支持细胞中校正基因缺陷/表达蛋白质的用途 Download PDF

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CN113853437A
CN113853437A CN201980082439.4A CN201980082439A CN113853437A CN 113853437 A CN113853437 A CN 113853437A CN 201980082439 A CN201980082439 A CN 201980082439A CN 113853437 A CN113853437 A CN 113853437A
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E.J.西蒙斯
R.恩格
D.伦兹
M.瓦莱罗
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Abstract

本文提供了包含至少两种不同的核酸载体的组合物，所述至少两种不同的载体，当被引入到灵长类动物细胞中时，经历彼此串联或同源重组，从而形成编码全长靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)的重组核酸。还提供了包含单一AAV载体的组合物，所述单一AAV载体，当被引入到灵长类动物细胞中时，在支持细胞靶基因的基因座处产生了编码全长靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)的核酸，并且所述灵长类动物表达靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)。

Description

腺相关病毒载体用于在内耳中的毛细胞和支持细胞中校正基 因缺陷/表达蛋白质的用途
相关申请的交叉引用
本申请要求2018年11月7日提交的的序列号为62/756,953的美国临时专利申请和2019年8月16日提交的序列号为62/888,093的美国临时专利申请的优先权，所述申请的全部内容通过引用并入本文。
技术领域
本公开总体上涉及核酸治疗灵长类动物的听力损失的用途。
发明背景
听力损失可以是传导性的(从耳道或中耳引起的)、感音神经性的(从内耳或听觉神经引起)或混合性的。大多数形式的非综合征性耳聋都与内耳结构受损引起的永久性听力损失(感音神经性耳聋)相关联，尽管一些形式可能涉及中耳的变化(传导性听力损失)。人的大部分感音神经性听力损失是由耳蜗中Corti器的毛细胞异常(毛细胞功能差)引起的。毛细胞在出生时可能是异常的，或者在个体的一生中可能会受到损害(例如，由于噪音创伤或感染所致)。
发明内容
本发明基于以下发现：包含至少两种不同的核酸载体的组合物，其中：所述至少两种不同的腺相关病毒(AAV)载体中的每一种均包含编码序列，所述编码序列编码支持细胞靶蛋白的不同部分，所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；所述至少两种不同的载体中单一载体均不编码全长支持细胞靶蛋白；所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列；以及所述至少两种不同的载体，当被引入到灵长类动物细胞中时，经历彼此串联或同源重组，从而形成编码全长支持细胞靶蛋白的重组核酸。
本文提供了包含至少两种不同的核酸载体的组合物，其中：所述至少两种不同的腺相关病毒(AAV)载体中的每一种均包含编码序列，所述编码序列编码支持细胞靶蛋白的不同部分，所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；所述至少两种不同的载体中单一载体均不编码全长支持细胞靶蛋白；所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列；以及所述至少两种不同的载体，当被引入到灵长类动物细胞中时，经历彼此串联或同源重组，从而形成编码全长支持细胞靶蛋白的重组核酸。
在本文所述的任何组合物的一些实施方案中，所述编码的部分之一的氨基酸序列与所述编码的部分中的不同的一个部分的氨基酸序列重叠。在本文所述的任何组合物的一些实施方案中，所述编码的部分中的每一个的氨基酸序列与不同的编码的部分的氨基酸序列部分地重叠。在本文所述的任何组合物的一些实施方案中，重叠氨基酸序列的长度为30个氨基酸残基至约390个氨基酸残基。
在本文所述的任何组合物的一些实施方案中，所述至少两种不同的载体中的每一种包含内含子的不同区段，其中所述内含子包含存在于支持细胞靶基因组DNA中的内含子的核苷酸序列，并且其中两个不同的区段在序列上重叠至少100个核苷酸。在本文所述的任何组合物的一些实施方案中，所述两个不同的区段在序列上重叠约30个核苷酸至约390个核苷酸。在本文所述的任何组合物的一些实施方案中，所述至少两种不同的载体中的每一种的核苷酸序列的长度为约30个核苷酸至约390个核苷酸。在本文所述的任何组合物的一些实施方案中，所述至少两种不同的载体中的每一种的核苷酸序列的长度为30个核苷酸至340个核苷酸。
在本文所述的任何组合物的一些实施方案中，所述组合物中不同载体的数目为2。在本文所述的任何组合物的一些实施方案中，所述两种不同的载体中的第一载体包含编码所述支持细胞靶蛋白的N末端部分的编码序列。在本文描述的任何组合物的一些实施方案中，支持细胞靶蛋白的N-末端部分的长度为约30个氨基酸至约390个氨基酸。在本文描述的任何组合物的一些实施方案中，支持细胞靶蛋白的N-末端部分的长度为约30个氨基酸至约340个氨基酸。在本文所述的任何组合物的一些实施方案中，第一载体还包含启动子和Kozak序列之一者或两者。在本文所述的任何组合物的一些实施方案中，第一载体包含启动子，所述启动子为诱导型启动子、组成型启动子或组织特异性启动子。
在本文所述的任何组合物的一些实施方案中，两种不同的载体中的第二载体包含编码支持细胞靶蛋白的C末端部分的编码序列。在本文描述的任何组合物的一些实施方案中，支持细胞靶蛋白的C-末端部分的长度为约30个氨基酸至约390个氨基酸。在本文描述的任何组合物的一些实施方案中，支持细胞靶蛋白的C-末端部分的长度为约30个氨基酸至约340个氨基酸。在本文所述的任何组合物的一些实施方案中，第二载体还包含poly(dA)序列。
本文还提供了包含两种不同的核酸载体的组合物，其中：所述两种不同的核酸载体中的第一核酸载体包含启动子、位于所述启动子的3’的编码支持细胞靶蛋白的N末端部分的第一编码序列和位于所述第一编码序列的3’末端的剪接供体信号序列；以及所述两种不同的核酸载体中的第二核酸载体包含剪接受体信号序列、位于所述剪接受体信号序列的3'末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多聚腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的氨基酸序列不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。
在本文所述的任何组合物的一些实施方案中，所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在相邻外显子之间缺乏内含子序列。
本文还提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3'的编码支持细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列，和位于所述剪接供体信号序列的3’的第一可检测标记基因；以及第二核酸载体，其与所述第一核酸载体不同，包含第二可检测标记基因、位于所述第二可检测标记基因的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。
在本文所述的任何组合物的一些实施方案中，所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在相邻外显子之间缺乏内含子序列。在本文所述的任何组合物的一些实施方案中，所述第一可检测标记基因或所述第二可检测标记基因是碱性磷酸酶。在本文所述的任何组合物的一些实施方案中，所述第一可检测标记基因和所述第二可检测标记基因是相同的。
本文还提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3'的编码支持细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列，和位于所述剪接供体信号序列的3’的F1噬菌体重组发生区；和第二核酸载体，其与所述第一核酸载体不同，包含第二F1噬菌体重组发生区、位于所述第二F1噬菌体重组发生区的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。
在本文所述的任何组合物的一些实施方案中，所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列。
本文还提供了包含单一腺相关病毒(AAV)载体的组合物，其中所述单一AAV载体包含编码支持细胞靶蛋白的核酸序列；以及当被引入到灵长类动物细胞中时，在支持细胞靶基因的基因座处产生编码全长支持细胞靶蛋白的核酸，并且所述灵长类动物表达所述支持细胞靶蛋白。
在本文所述的任何组合物的一些实施方案中，所述支持细胞靶基因是缝隙连接蛋白β2(GJB2)。在本文所述的任何组合物的一些实施方案中，所述支持细胞靶基因是溶质运载蛋白家族26成员4(SLC26A4)。
在本文所述的任何组合物的一些实施方案中，所述组合物还包含药学上可接受的赋形剂。
在本文所述的任何组合物的一些实施方案中，第二核酸载体还包含失稳序列。
在本文所述的任何组合物的一些实施方案中，第二核酸载体还包含FKBP12失稳序列。
本文还提供了包括本文所述的任何组合物的试剂盒。在本文所述的任何试剂盒的一些实施方案中，试剂盒还包括包含所述组合物的预装式注射器。
本文还提供了校正灵长类动物内耳的支持细胞中的支持细胞靶基因缺陷的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用修复所述灵长类动物内耳的支持细胞中的支持细胞靶基因缺陷。
本文还提供了升高灵长类动物内耳的支持细胞中的支持细胞靶蛋白的表达水平的方法，所述方法包括向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用使得所述灵长类动物内耳的支持细胞中的所述支持细胞靶蛋白的表达水平升高。
在本文所述的任何方法的一些实施方案中，所述灵长类动物先前已被确定具有缺陷型支持细胞靶基因。
本文还提供了治疗被鉴定为具有缺陷型支持细胞靶基因的灵长类动物的非综合征性感音神经性听力损失的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。
在本文所述的任何方法的一些实施方案中，所述方法还包括在施用步骤之前，确定灵长类动物具有缺陷型毛细胞靶基因。
本文还提供了恢复被鉴定或诊断为患有听力损失的灵长类动物的听力的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的如本文所述的任何组合物。
在本文所述的任何方法的一些实施方案中，所述方法还包括在施用步骤之前，确定灵长类动物具有缺陷型支持细胞靶基因。
本文还提供了恢复被鉴定或诊断为患有内耳病症的灵长类动物的突触并且/或者保留其螺旋神经节神经的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。
在本文所述的任何方法的一些实施方案中，所述方法还包括在施用步骤之前，确定灵长类动物具有缺陷型支持细胞靶基因。
本文还提供了包括向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物的方法。
在本文所述的任何方法的一些实施方案中，所述灵长类动物先前已被鉴定为具有缺陷型支持细胞靶基因。
本文还提供了包含至少两种不同的核酸载体的组合物，其中：所述至少两种不同的腺相关病毒(AAV)载体中的每一种均包含编码序列，所述编码序列编码毛细胞靶蛋白的不同部分，所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；所述至少两种不同的载体中单一载体均不编码全长毛细胞靶蛋白；所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺少内含子序列；以及所述至少两种不同的载体，当被引入到灵长类动物细胞中时，经历彼此串联或同源重组，从而形成编码全长毛细胞靶蛋白的重组核酸。
本文提供了包含至少两种不同的核酸载体的组合物，其中：所述至少两种不同的腺相关病毒(AAV)载体中的每一种均包含编码毛细胞靶蛋白的不同部分的编码序列，所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；所述至少两种不同的载体中单一载体均不编码全长蛋白质；所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列；并且当被引入到灵长类动物细胞时，所述至少两种不同的载体经历彼此串联或同源重组，从而形成编码全长毛细胞靶蛋白的重组核酸。
在本文所述的任何组合物的一些实施方案中，所述编码的部分之一的氨基酸序列与所述编码的部分中的不同的一个部分的氨基酸序列重叠。在本文所述的任何组合物的一些实施方案中，所述编码的部分中的每一个的氨基酸序列与不同的编码的部分的氨基酸序列部分地重叠。在本文所述的任何组合物的一些实施方案中，重叠氨基酸序列的长度为30个氨基酸残基至约390个氨基酸残基。
在本文所述的任何组合物的一些实施方案中，所述至少两种不同的载体中的每一种包含内含子的不同区段，其中所述内含子包含存在于毛细胞靶基因组DNA中的内含子的核苷酸序列，并且其中两个不同的区段在序列上重叠至少100个核苷酸。在本文所述的任何组合物的一些实施方案中，所述两个不同的区段在序列上重叠约30个核苷酸至约390个核苷酸。在本文所述的任何组合物的一些实施方案中，所述至少两种不同的载体中的每一种的核苷酸序列的长度为约30个核苷酸至约390个核苷酸。在本文所述的任何组合物的一些实施方案中，所述至少两种不同的载体中的每一种的核苷酸序列的长度为30个核苷酸至340个核苷酸。
在本文所述的任何组合物的一些实施方案中，所述组合物中不同载体的数目为2。在本文所述的任何组合物的一些实施方案中，所述两种不同的载体中的第一载体包含编码毛细胞靶蛋白的N末端部分的编码序列。在本文所述的任何组合物的一些实施方案中，毛细胞靶蛋白的N末端部分的长度为约30个氨基酸至约390个氨基酸。在本文所述的任何组合物的一些实施方案中，毛细胞靶蛋白的N末端部分的长度为约30个氨基酸至约340个氨基酸。在本文所述的任何组合物的一些实施方案中，第一载体还包含启动子和Kozak序列之一者或两者。在本文所述的任何组合物的一些实施方案中，第一载体包含启动子，所述启动子为诱导型启动子、组成型启动子或组织特异性启动子。
在本文所述的任何组合物的一些实施方案中，所述两种不同的载体中的第二载体包括编码毛细胞靶蛋白的C末端部分的编码序列。在本文所述的任何组合物的一些实施方案中，所述毛细胞靶蛋白的C-末端部分的长度为约30个氨基酸至约390个氨基酸。在本文所述的任何组合物的一些实施方案中，毛细胞靶蛋白的C-末端部分的长度为约30个氨基酸至约340个氨基酸。在本文所述的任何组合物的一些实施方案中，第二载体还包含poly(dA)序列。
本文还提供了包含两种不同的核酸载体的组合物，其中：所述两种不同的核酸载体中的第一核酸载体包含启动子、位于所述启动子3’的编码毛细胞靶蛋白的N末端部分的第一编码序列和位于所述第一编码序列的3’末端的剪接供体信号序列；以及所述两种不同的核酸载体中的第二核酸载体包含剪接受体信号序列、位于所述剪接受体信号序列的3'末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多聚腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的氨基酸序列不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。
在本文所述的任何组合物的一些实施方案中，所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在相邻外显子之间缺乏内含子序列。
本文还提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3'的编码毛细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列，和位于所述剪接供体信号序列的3’的第一可检测标记基因；和第二核酸载体，其与所述第一核酸载体不同，包含第二可检测标记基因、位于所述第二可检测标记基因的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。
在本文所述的任何组合物的一些实施方案中，所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在相邻外显子之间缺乏内含子序列。在本文所述的任何组合物的一些实施方案中，所述第一可检测标记基因或所述第二可检测标记基因是碱性磷酸酶。在本文所述的任何组合物的一些实施方案中，所述第一可检测标记基因和所述第二可检测标记基因是相同的。
本文还提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3’的编码毛细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列和位于所述剪接供体信号序列的3’的F1噬菌体重组发生区；和第二核酸载体，其与所述第一核酸载体不同，包含第二F1噬菌体重组发生区、位于所述第二F1噬菌体重组发生区的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的剪接供体信号与另一个转录物上的剪接受体信号之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。
在本文所述的任何组合物的一些实施方案中，所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在两个相邻外显子之间缺乏内含子序列。
本文还提供了包含单一腺相关病毒(AAV)载体的组合物，其中所述单一AAV载体包含编码毛细胞靶蛋白的核酸序列；当被引入到灵长类动物细胞时，在所述毛细胞靶基因的基因座处产生编码全长毛细胞靶蛋白的核酸，并且所述灵长类动物表达所述毛细胞靶蛋白。
在本文所述的任何组合物的一些实施方案中，所述组合物还包含药学上可接受的赋形剂。
本文还提供了包括本文所述的任何组合物的试剂盒。在本文所述的任何试剂盒的一些实施方案中，试剂盒还包括包含所述组合物的预装式注射器。
本文还提供了校正灵长类动物内耳的毛细胞中的毛细胞靶基因缺陷的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用修复所述灵长类动物内耳的毛细胞中的毛细胞靶基因缺陷。
本文还提供了升高灵长类动物内耳的毛细胞中的毛细胞靶蛋白的表达水平的方法，所述方法包括向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用使得所述灵长类动物内耳的所述毛细胞中的所述毛细胞靶蛋白的表达水平升高。
在本文所述的任何方法的一些实施方案中，所述灵长类动物先前已被确定具有缺陷型毛细胞靶基因。
本文还提供了治疗被鉴定为具有缺陷型毛细胞靶基因的灵长类动物的非综合征性感音神经性听力损失的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。
在本文所述的任何方法的一些实施方案中，所述方法还包括在所述施用步骤之前，确定所述灵长类动物具有缺陷型毛细胞靶基因。
本文还提供了恢复被鉴定或诊断为患有听力损失的灵长类动物的听力的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的如本文所述的任何组合物。
在本文所述的任何方法的一些实施方案中，所述方法还包括在施用步骤之前，确定灵长类动物具有缺陷型毛细胞靶基因。
本文还提供了恢复被鉴定或诊断为患有内耳病症的灵长类动物的突触并且/或者保留其螺旋神经节神经的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。
在本文所述的任何方法的一些实施方案中，所述方法还包括在施用步骤之前，确定灵长类动物具有缺陷型毛细胞靶基因。
本文还提供了包括向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物的方法。
在本文所述的任何方法的一些实施方案中，所述灵长类动物先前已被鉴定为具有缺陷型毛细胞靶基因。
术语“一个/种(a)”和“一个/种(an)”是指一个/种或不止一个/种(即，至少一个/种)该冠词的语法对象。举例来说，“一个(an)元件”涵盖一个元件和不止一个元件。
术语“支持细胞靶蛋白”意指在灵长类动物的支持细胞中表达并且在功能上至少部分有助于灵长类动物的听力的蛋白质。支持细胞靶蛋白的非限制性实例包括GJB2和SLC26A4。
术语“支持细胞靶基因中的突变”是指野生型支持细胞靶基因中的修饰，所述修饰导致产生与野生型支持细胞靶蛋白相比具有：一个或多个氨基酸的缺失、一个或多个氨基酸取代和一个或多个氨基酸插入中的一者或多者的支持细胞靶蛋白，并且/或者导致与不具有突变的灵长类动物细胞中的所述编码的支持细胞靶蛋白的表达水平相比，灵长类动物细胞中的编码的支持细胞靶蛋白的表达水平降低。在一些实施方案中，突变可导致在一个或多个氨基酸(例如，2个、3个、4个、5个、6个、7个、8个、9个、10个、11个、12个、13个、14个、1516个、17个、18个、19个或20个氨基酸)处具有缺失的支持细胞靶蛋白产生。在一些实施方案中，所述突变可在支持细胞靶基因中导致移码。
术语“毛细胞靶蛋白”意指在灵长类动物的毛细胞中表达，并且在功能上至少部分有助于灵长类动物的听力的蛋白质。毛细胞靶蛋白的非限制性实例包括覆膜蛋白α(tectorin alpha)(TECTA)、非常规肌球蛋白-15(MYO15A)、肌球蛋白IIIA(MYO3A)、肌球蛋白VI(MYO6)、肌球蛋白VIIA(MYO7A)、钙粘蛋白相关23(CDH23)、胶原XIα2型链(COL11A2)、脂氧合酶同源结构域1(LOXHD1)、原钙粘蛋白相关15(PCDH15)、旋蛋白(whirlin)(WHRN)、耳畸蛋白(OTOF)基因、trio rho鸟嘌呤核苷酸交换因子(TRIO)和f-肌动蛋白结合蛋白(TRIOBP)基因、硬纤毛蛋白(stereocilin)(STRC)基因、pejvakin(PJVK)基因、norrin半胱氨酸结生长因子(NDP)基因、clarin 1(CLRN1)基因、跨膜通道样1(TMC1)基因、血管内皮生长因子(VEGF)基因和热休克蛋白家族A(Hsp70)成员1A(HSPA1A)基因。
术语“毛细胞靶基因中的突变”是指野生型毛细胞靶基因中的修饰，所述修饰导致产生与野生型毛细胞靶蛋白相比具有：一个或多个氨基酸的缺失、一个或多个氨基酸取代和一个或多个氨基酸插入中的一者或多者的毛细胞靶蛋白，并且/或者导致与不具有突变的灵长类动物细胞中的编码的毛细胞靶蛋白的表达水平相比，灵长类动物细胞中的所述编码的毛细胞靶蛋白的表达水平降低。在一些实施方案中，突变可导致在一个或多个氨基酸(例如，2个、3个、4个、5个、6个、7个、8个、9个、10个、11个、12个、13个、14个、15 16个、17个、18个、19个或20个氨基酸)处具有缺失的毛细胞靶蛋白产生。在一些实施方案中，所述突变可在毛细胞靶基因中导致移码。
已知术语“移码”在本领域中涵盖编码序列中导致编码序列的阅读框中的移位的任何突变。在一些实施方案中，移码可导致无功能的蛋白质。在一些实施方案中，点突变可以是无义突变(即，在基因的外显子中导致提前终止密码子)。无义突变可导致产生可以具有或可以不具有功能的截短的蛋白质(与相应的野生型蛋白质相比)。在一些实施方案中，所述突变可导致毛细胞靶mRNA或毛细胞靶蛋白或mRNA和蛋白两者的表达损失(或水平降低)。在一些实施方案中，与野生型毛细胞靶蛋白相比，所述突变可导致改变的毛细胞靶蛋白的产生，所述改变的毛细胞靶蛋白的一种或多种生物活性(功能)损失或降低。在一些实施方案中，所述突变可导致支持细胞靶mRNA或支持细胞靶蛋白或mRNA和蛋白两者的表达损失(或水平降低)。在一些实施方案中，与野生型支持细胞靶蛋白相比，所述突变可导致改变的支持细胞靶蛋白产生，所述改变的支持细胞靶蛋白的一种或多种生物活性(功能)损失或降低。
在一些实施方案中，所述突变是一个或多个核苷酸至毛细胞靶基因中的插入。在一些实施方案中，所述突变存在于毛细胞靶基因的调控序列(即，该基因的非编码序列的一部分)中。在一些实施方案中，调控序列中的突变可存在于启动子或增强子区域中，并阻止或减少毛细胞靶基因的适当转录。在一些实施方案中，所述突变是一个或多个核苷酸至支持细胞靶基因中的插入。在一些实施方案中，所述突变位于支持细胞靶基因的调控序列(即，该基因的非编码序列的一部分)。在一些实施方案中，调控序列中的突变可存在于启动子或增强子区域中，并阻止或减少支持细胞靶基因的适当转录。术语“保守突变”是指不改变在突变位点处编码的氨基酸的突变(由于密码子简并性)。
可通过本领域已知的标准技术诸如定点诱变和PCR介导的诱变将修饰引入核苷酸序列中。保守氨基酸取代是其中氨基酸残基被具有相似侧链的氨基酸残基替代的氨基酸取代。本领域已经定义了具有相似侧链的氨基酸残基的家族。这些家族包括具有碱性侧链(例如，赖氨酸、精氨酸和组氨酸)、酸性侧链(例如。天冬氨酸和谷氨酸)、不带电荷的极性侧链(例如，甘氨酸、天冬酰胺、谷氨酰胺、丝氨酸、苏氨酸、酪氨酸、半胱氨酸和色氨酸)、非极性侧链(例如，丙氨酸、缬氨酸、亮氨酸、异亮氨酸、脯氨酸、苯丙氨酸和蛋氨酸)、β-支链侧链(例如，苏氨酸、缬氨酸和异亮氨酸)和芳族侧链(例如，酪氨酸、苯丙氨酸、色氨酸和组氨酸)的氨基酸。
除非另外规定，否则“编码氨基酸序列的核苷酸序列”包括是彼此的简并形式并因此编码相同的氨基酸序列的所有核苷酸序列。
术语“内源的”是指源自生物体、细胞或组织内的任何材料。
术语“外源的”是指从生物体、细胞或组织的外部引入或源自外部的任何材料，所述材料不从将引入其的同一生物体、细胞或组织产生，或者不源自所述同一生物体、细胞或组织。
术语“分离的”意指从天然状态改变或去除。例如，天然存在于活的动物中的核酸或肽不是“分离的”，但与共存材料部分或完全分开的相同核酸或肽是“分离的”。分离的核酸或蛋白质可以以基本上纯化的形式存在，或者可以存在于非天然环境例如宿主细胞中。
术语“转染的”、“转化的”或“转导的”是指将外源性核酸转移或引入细胞的过程。“转染的”、“转化的”或“转导的”灵长类动物细胞是已用外源性核酸转染、转化或转导的细胞。
术语“表达”是指编码蛋白质的特定核苷酸序列的转录和/或翻译。
术语“瞬时表达”是指非整合编码序列在短时间段(例如，数小时或数天)中的表达。在细胞(例如，灵长类动物细胞)中瞬时表达的编码序列在多轮细胞分裂后丢失。
术语“灵长类动物”意图包括任何灵长类动物(例如，人类、非人灵长类动物(例如，猿猴(例如，猴子(例如狨猴、狒狒或猕猴)或猿(例如，大猩猩、长臂猿、猩猩或黑猩猩)。在一些实施方案中，灵长类动物患有听力损失或有患听力损失的风险。在一些实施方案中，灵长类动物先前已经被鉴定为在毛细胞靶基因(例如，OTOF基因、TRIOBP基因、STRC基因、PJVK基因、NDP基因、CLRN1基因、TMC1基因、VEGF基因或HSPA1A基因)中具有突变。在一些实施方案中，灵长类动物先前已经被鉴定为在支持细胞靶基因(例如，GJB2基因或SLC26A4基因)中具有突变。在一些实施方案中，灵长类动物先前已被鉴定为在GJB2基因中具有突变。在一些实施方案中，灵长类动物先前已被鉴定为在SLC26A4基因中具有突变。在一些实施方案中，灵长类动物已被鉴定为在毛细胞靶基因(例如，OTOF基因、TRIOBP基因、STRC基因、PJVK基因、NDP基因、CLRN1基因、TMC1基因、VEGF基因或HSPA1A基因)中具有突变，并已被诊断为患有听力损失。在一些实施方案中，灵长类动物已经被鉴定为在支持细胞靶基因(例如，GBJ2基因或SLC26A4基因)中具有突变，并且已经被诊断患有听力损失。在一些实施方案中，灵长类动物已被鉴定为患有听力损失。
当治疗导致灵长类动物的疾病状态(听力损失，例如，非综合征性感音神经性听力损失或综合征性感音神经性听力损失)的一种或多种症状的数量、严重程度和频率中的一种或多种降低时，所述治疗是“治疗有效的”。在一些实施方案中，治疗有效量的组合物可导致活性靶蛋白(例如，支持细胞靶蛋白(例如，具有所需活性的野生型全长支持细胞靶蛋白或支持细胞靶蛋白的变体))(例如，与用该组合物处理之前的表达水平相比)或毛细胞靶蛋白(例如，具有所需活性的野生型全长毛细胞靶蛋白或毛细胞靶蛋白的变体))(例如，与用该组合物处理之前的表达水平相比)的表达水平升高。在一些实施方案中，治疗有效量的组合物可导致靶细胞(例如，支持细胞或毛细胞)中活性靶蛋白(例如，活性支持细胞靶蛋白(例如，野生型全长支持细胞靶蛋白或活性变体)或活性毛细胞靶蛋白(例如，野生型全长毛细胞靶蛋白或活性变体))的表达水平升高。在一些实施方案中，治疗有效量的组合物可导致靶细胞中活性靶蛋白(例如，活性支持细胞靶蛋白(例如，野生型全长支持细胞靶蛋白或活性变体)或活性毛细胞靶蛋白(例如，野生型全长毛细胞靶蛋白或活性变体)的表达水平升高和/或靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)的一种或多种活性增强(例如，与参考水平，诸如治疗前的灵长类动物中的一个或多个水平、在靶基因(例如，支持细胞靶基因或毛细胞靶基因)中具有突变的灵长类动物中的一个或多个水平或患有听力损失(例如，非综合征性感音神经性听力损失或综合征性感音神经性听力损失)的灵长类动物或灵长类动物群中的一个或多个水平相比)。
术语“核酸”或“多核苷酸”是指单链或双链形式的脱氧核糖核酸(DNA)或核糖核酸(RNA)或其组合。除非特别限制，否则所述术语涵盖含有已知的天然核苷酸类似物的核酸，所述天然核苷酸类似物具有与参考核苷酸相似的结合特性。除非另有说明，否则特定的核酸序列也隐含地涵盖互补序列以及明确指示的序列。在本文所述的任何核酸的一些实施方案中，核酸为DNA。在本文所述的任何核酸的一些实施方案中，核酸为RNA。
术语“活性毛细胞靶蛋白”意指由这样的DNA编码的蛋白质，所述DNA，如果取代原本属于野生型灵长类动物的毛细胞中两个编码全长毛细胞靶蛋白的野生型等位基因，并且如果在该灵长类动物的毛细胞中表达，会导致该灵长类动物的听力水平接近为完全野生型的类似灵长类动物的正常听力水平。活性毛细胞靶蛋白的非限制性实例是全长毛细胞靶蛋白(例如，本文所述的任何全长毛细胞靶蛋白)。
术语“活性支持细胞靶蛋白”是指由这样的DNA编码的蛋白质，所述DNA，如果取代原本属于野生型灵长类动物的支持细胞中两个编码全长支持细胞靶蛋白的野生型等位基因，并且如果在该灵长类动物的支持细胞中表达，会导致该灵长类动物的听力水平接近为完全野生型的类似灵长类动物的正常听力水平。活性支持细胞靶蛋白的非限制性实例是全长支持细胞靶蛋白(例如，本文所述的任何全长支持细胞靶蛋白)。
例如，活性靶蛋白(例如，活性支持细胞靶蛋白或活性毛细胞靶蛋白)可包含野生型全长靶蛋白(例如，支持细胞靶蛋白(例如，野生型人全长支持细胞靶蛋白)或毛细胞靶蛋白(例如，野生型人全长毛细胞靶蛋白))的序列，所述野生型全长靶蛋白的序列包含1个氨基酸取代至约160个氨基酸取代、1个氨基酸取代至约155个氨基酸取代、1个氨基酸取代至约150个氨基酸取代、1个氨基酸取代至约145个氨基酸取代、1个氨基酸取代至约140个氨基酸取代、1个氨基酸取代至约135个氨基酸取代、1个氨基酸取代至约130个氨基酸取代、1个氨基酸取代至约125个氨基酸取代、1个氨基酸取代至约120个氨基酸取代、1个氨基酸取代至约115个氨基酸取代、1个氨基酸取代至约110个氨基酸取代、1个氨基酸取代至约105个氨基酸取代、1个氨基酸取代至约100个氨基酸取代、1个氨基酸取代至约95个氨基酸取代、1个氨基酸取代至约90个氨基酸取代、1个氨基酸取代至约85个氨基酸取代、1个氨基酸取代至约80个氨基酸取代、1个氨基酸取代至约75个氨基酸取代、1个氨基酸取代至约70个氨基酸取代、1个氨基酸取代至约65个氨基酸取代、1个氨基酸取代至约60个氨基酸取代、1个氨基酸取代至约55个氨基酸取代、1个氨基酸取代至约50个氨基酸取代、1个氨基酸取代至约45个氨基酸取代、1个氨基酸取代至约40个氨基酸取代、1个氨基酸取代至约35个氨基酸取代、1个氨基酸取代至约30个氨基酸取代、1个氨基酸取代至约25个氨基酸取代、1个氨基酸取代至约20个氨基酸取代、1个氨基酸取代至约15个氨基酸取代、1个氨基酸取代至约10个氨基酸取代、1个氨基酸取代至约9个氨基酸取代、1个氨基酸取代至约8个氨基酸取代、1个氨基酸取代至约7个氨基酸取代、1个氨基酸取代至约6个氨基酸取代、1个氨基酸取代至约5个氨基酸取代、1个氨基酸取代至约4个氨基酸取代、1个氨基酸取代至约3个氨基酸取代、约2个氨基酸取代至约160个氨基酸取代、约2个氨基酸取代至约155个氨基酸取代、约2个氨基酸取代至约150个氨基酸取代、约2个氨基酸取代至约145个氨基酸取代、约2个氨基酸取代至约140个氨基酸取代、约2个氨基酸取代至约135个氨基酸取代、约2个氨基酸取代至约130个氨基酸取代、约2个氨基酸取代至约125个氨基酸取代、约2个氨基酸取代至约120个氨基酸取代、约2个氨基酸取代至约115个氨基酸取代、约2个氨基酸取代至约110个氨基酸取代、约2个氨基酸取代至约105个氨基酸取代、约2个氨基酸取代至约100个氨基酸取代、约2个氨基酸取代至约95个氨基酸取代、约2个氨基酸取代至约90个氨基酸取代、约2个氨基酸取代至约85个氨基酸取代、约2个氨基酸取代至约80个氨基酸取代、约2个氨基酸取代至约75个氨基酸取代、约2个氨基酸取代至约70个氨基酸取代、约2个氨基酸取代至约65个氨基酸取代、约2个氨基酸取代至约60个氨基酸取代、约2个氨基酸取代至约55个氨基酸取代、约2个氨基酸取代至约50个氨基酸取代、约2个氨基酸取代至约45个氨基酸取代、约2个氨基酸取代至约40个氨基酸取代、约2个氨基酸取代至约35个氨基酸取代、约2个氨基酸取代至约30个氨基酸取代、约2个氨基酸取代至约25个氨基酸取代、约2个氨基酸取代至约20个氨基酸取代、约2个氨基酸取代至约15个氨基酸取代、约2个氨基酸取代至约10个氨基酸取代、约2个氨基酸取代至约9个氨基酸取代、约2个氨基酸取代至约8个氨基酸取代、约2个氨基酸取代至约7个氨基酸取代、约2个氨基酸取代至约6个氨基酸取代、约2个氨基酸取代至约5个氨基酸取代、约2个氨基酸取代至约4个氨基酸取代、约3个氨基酸取代至约160个氨基酸取代、约3个氨基酸取代至约155个氨基酸取代、约3个氨基酸取代至约150个氨基酸取代、约3个氨基酸取代至约145个氨基酸取代、约3个氨基酸取代至约140个氨基酸取代、约3个氨基酸取代至约135个氨基酸取代、约3个氨基酸取代至约130个氨基酸取代、约3个氨基酸取代至约125个氨基酸取代、约3个氨基酸取代至约120个氨基酸取代、约3个氨基酸取代至约115个氨基酸取代、约3个氨基酸取代至约110个氨基酸取代、约3个氨基酸取代至约105个氨基酸取代、约3个氨基酸取代至约100个氨基酸取代、约3个氨基酸取代至约95个氨基酸取代、约3个氨基酸取代至约90个氨基酸取代、约3个氨基酸取代至约85个氨基酸取代、约3个氨基酸取代至约80个氨基酸取代、约3个氨基酸取代至约75个氨基酸取代、约3个氨基酸取代至约70个氨基酸取代、约3个氨基酸取代至约65个氨基酸取代、约3个氨基酸取代至约60个氨基酸取代、约3个氨基酸取代至约55个氨基酸取代、约3个氨基酸取代至约50个氨基酸取代、约3个氨基酸取代至约45个氨基酸取代、约3个氨基酸取代至约40个氨基酸取代、约3个氨基酸取代至约35个氨基酸取代、约3个氨基酸取代至约30个氨基酸取代、约3个氨基酸取代至约25个氨基酸取代、约3个氨基酸取代至约20个氨基酸取代、约3个氨基酸取代至约15个氨基酸取代、约3个氨基酸取代至约10个氨基酸取代、约3个氨基酸取代至约9个氨基酸取代、约3个氨基酸取代至约8个氨基酸取代、约3个氨基酸取代至约7个氨基酸取代、约3个氨基酸取代至约6个氨基酸取代、约3个氨基酸取代至约5个氨基酸取代、约4个氨基酸取代至约160个氨基酸取代、约4个氨基酸取代至约155个氨基酸取代、约4个氨基酸取代至约150个氨基酸取代、约4个氨基酸取代至约145个氨基酸取代、约4个氨基酸取代至约140个氨基酸取代、约4个氨基酸取代至约135个氨基酸取代、约4个氨基酸取代至约130个氨基酸取代、约4个氨基酸取代至约125个氨基酸取代、约4个氨基酸取代至约120个氨基酸取代、约4个氨基酸取代至约115个氨基酸取代、约4个氨基酸取代至约110个氨基酸取代、约4个氨基酸取代至约105个氨基酸取代、约4个氨基酸取代至约100个氨基酸取代、约4个氨基酸取代至约95个氨基酸取代、约4个氨基酸取代至约90个氨基酸取代、约4个氨基酸取代至约85个氨基酸取代、约4个氨基酸取代至约80个氨基酸取代、约4个氨基酸取代至约75个氨基酸取代、约4个氨基酸取代至约70个氨基酸取代、约4个氨基酸取代至约65个氨基酸取代、约4个氨基酸取代至约60个氨基酸取代、约4个氨基酸取代至约55个氨基酸取代、约4个氨基酸取代至约50个氨基酸取代、约4个氨基酸取代至约45个氨基酸取代、约4个氨基酸取代至约40个氨基酸取代、约4个氨基酸取代至约35个氨基酸取代、约4个氨基酸取代至约30个氨基酸取代、约4个氨基酸取代至约25个氨基酸取代、约4个氨基酸取代至约20个氨基酸取代、约4个氨基酸取代至约15个氨基酸取代、约4个氨基酸取代至约10个氨基酸取代、约4个氨基酸取代至约9个氨基酸取代、约4个氨基酸取代至约8个氨基酸取代、约4个氨基酸取代至约7个氨基酸取代、约4个氨基酸取代至约6个氨基酸取代、约5个氨基酸取代至约160个氨基酸取代、约5个氨基酸取代至约155个氨基酸取代、约5个氨基酸取代至约150个氨基酸取代、约5个氨基酸取代至约145个氨基酸取代、约5个氨基酸取代至约140个氨基酸取代、约5个氨基酸取代至约135个氨基酸取代、约5个氨基酸取代至约130个氨基酸取代、约5个氨基酸取代至约125个氨基酸取代、约5个氨基酸取代至约120个氨基酸取代、约5个氨基酸取代至约115个氨基酸取代、约5个氨基酸取代至约110个氨基酸取代、约5个氨基酸取代至约105个氨基酸取代、约5个氨基酸取代至约100个氨基酸取代、约5个氨基酸取代至约95个氨基酸取代、约5个氨基酸取代至约90个氨基酸取代、约5个氨基酸取代至约85个氨基酸取代、约5个氨基酸取代至约80个氨基酸取代、约5个氨基酸取代至约75个氨基酸取代、约5个氨基酸取代至约70个氨基酸取代、约5个氨基酸取代至约65个氨基酸取代、约5个氨基酸取代至约60个氨基酸取代、约5个氨基酸取代至约55个氨基酸取代、约5个氨基酸取代至约50个氨基酸取代、约5个氨基酸取代至约45个氨基酸取代、约5个氨基酸取代至约40个氨基酸取代、约5个氨基酸取代至约35个氨基酸取代、约5个氨基酸取代至约30个氨基酸取代、约5个氨基酸取代至约25个氨基酸取代、约5个氨基酸取代至约20个氨基酸取代、约5个氨基酸取代至约15个氨基酸取代、约5个氨基酸取代至约10个氨基酸取代、约5个氨基酸取代至约9个氨基酸取代、约5个氨基酸取代至约8个氨基酸取代、约5个氨基酸取代至约7个氨基酸取代、约6个氨基酸取代至约160个氨基酸取代、约6个氨基酸取代至约155个氨基酸取代、约6个氨基酸取代至约150个氨基酸取代、约6个氨基酸取代至约145个氨基酸取代、约6个氨基酸取代至约140个氨基酸取代、约6个氨基酸取代至约135个氨基酸取代、约6个氨基酸取代至约130个氨基酸取代、约6个氨基酸取代至约125个氨基酸取代、约6个氨基酸取代至约120个氨基酸取代、约6个氨基酸取代至约115个氨基酸取代、约6个氨基酸取代至约110个氨基酸取代、约6个氨基酸取代至约105个氨基酸取代、约6个氨基酸取代至约100个氨基酸取代、约6个氨基酸取代至约95个氨基酸取代、约6个氨基酸取代至约90个氨基酸取代、约6个氨基酸取代至约85个氨基酸取代、约6个氨基酸取代至约80个氨基酸取代、约6个氨基酸取代至约75个氨基酸取代、约6个氨基酸取代至约70个氨基酸取代、约6个氨基酸取代至约65个氨基酸取代、约6个氨基酸取代至约60个氨基酸取代、约6个氨基酸取代至约55个氨基酸取代、约6个氨基酸取代至约50个氨基酸取代、约6个氨基酸取代至约45个氨基酸取代、约6个氨基酸取代至约40个氨基酸取代、约6个氨基酸取代至约35个氨基酸取代、约6个氨基酸取代至约30个氨基酸取代、约6个氨基酸取代至约25个氨基酸取代、约6个氨基酸取代至约20个氨基酸取代、约6个氨基酸取代至约15个氨基酸取代、约6个氨基酸取代至约10个氨基酸取代、约6个氨基酸取代至约9个氨基酸取代、约6个氨基酸取代至约8个氨基酸取代、约7个氨基酸取代至约160个氨基酸取代、约7个氨基酸取代至约155个氨基酸取代、约7个氨基酸取代至约150个氨基酸取代、约7个氨基酸取代至约145个氨基酸取代、约7个氨基酸取代至约140个氨基酸取代、约7个氨基酸取代至约135个氨基酸取代、约7个氨基酸取代至约130个氨基酸取代、约7个氨基酸取代至约125个氨基酸取代、约7个氨基酸取代至约120个氨基酸取代、约7个氨基酸取代至约115个氨基酸取代、约7个氨基酸取代至约110个氨基酸取代、约7个氨基酸取代至约105个氨基酸取代、约7个氨基酸取代至约100个氨基酸取代、约7个氨基酸取代至约95个氨基酸取代、约7个氨基酸取代至约90个氨基酸取代、约7个氨基酸取代至约85个氨基酸取代、约7个氨基酸取代至约80个氨基酸取代、约7个氨基酸取代至约75个氨基酸取代、约7个氨基酸取代至约70个氨基酸取代、约7个氨基酸取代至约65个氨基酸取代、约7个氨基酸取代至约60个氨基酸取代、约7个氨基酸取代至约55个氨基酸取代、约7个氨基酸取代至约50个氨基酸取代、约7个氨基酸取代至约45个氨基酸取代、约7个氨基酸取代至约40个氨基酸取代、约7个氨基酸取代至约35个氨基酸取代、约7个氨基酸取代至约30个氨基酸取代、约7个氨基酸取代至约25个氨基酸取代、约7个氨基酸取代至约20个氨基酸取代、约7个氨基酸取代至约15个氨基酸取代、约7个氨基酸取代至约10个氨基酸取代、约7个氨基酸取代至约9个氨基酸取代、约8个氨基酸取代至约160个氨基酸取代、约8个氨基酸取代至约155个氨基酸取代、约8个氨基酸取代至约150个氨基酸取代、约8个氨基酸取代至约145个氨基酸取代、约8个氨基酸取代至约140个氨基酸取代、约8个氨基酸取代至约135个氨基酸取代、约8个氨基酸取代至约130个氨基酸取代、约8个氨基酸取代至约125个氨基酸取代、约8个氨基酸取代至约120个氨基酸取代、约8个氨基酸取代至约115个氨基酸取代、约8个氨基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取代至约100个氨基酸取代、约50个氨基酸取代至约95个氨基酸取代、约50个氨基酸取代至约90个氨基酸取代、约50个氨基酸取代至约85个氨基酸取代、约50个氨基酸取代至约80个氨基酸取代、约50个氨基酸取代至约75个氨基酸取代、约50个氨基酸取代至约70个氨基酸取代、约50个氨基酸取代至约65个氨基酸取代、约50个氨基酸取代至约60个氨基酸取代、约50个氨基酸取代至约55个氨基酸取代、约60个氨基酸取代至约160个氨基酸取代、约60个氨基酸取代至约155个氨基酸取代、约60个氨基酸取代至约150个氨基酸取代、约60个氨基酸取代至约145个氨基酸取代、约60个氨基酸取代至约140个氨基酸取代、约60个氨基酸取代至约135个氨基酸取代、约60个氨基酸取代至约130个氨基酸取代、约60个氨基酸取代至约125个氨基酸取代、约60个氨基酸取代至约120个氨基酸取代、约60个氨基酸取代至约115个氨基酸取代、约60个氨基酸取代至约110个氨基酸取代、约60个氨基酸取代至约105个氨基酸取代、约60个氨基酸取代至约100个氨基酸取代、约60个氨基酸取代至约95个氨基酸取代、约60个氨基酸取代至约90个氨基酸取代、约60个氨基酸取代至约85个氨基酸取代、约60个氨基酸取代至约80个氨基酸取代、约60个氨基酸取代至约75个氨基酸取代、约60个氨基酸取代至约70个氨基酸取代、约60个氨基酸取代至约65个氨基酸取代、约70个氨基酸取代至约160个氨基酸取代、约70个氨基酸取代至约155个氨基酸取代、约70个氨基酸取代至约150个氨基酸取代、约70个氨基酸取代至约145个氨基酸取代、约70个氨基酸取代至约140个氨基酸取代、约70个氨基酸取代至约135个氨基酸取代、约70个氨基酸取代至约130个氨基酸取代、约70个氨基酸取代至约125个氨基酸取代、约70个氨基酸取代至约120个氨基酸取代、约70个氨基酸取代至约115个氨基酸取代、约70个氨基酸取代至约110个氨基酸取代、约70个氨基酸取代至约105个氨基酸取代、约70个氨基酸取代至约100个氨基酸取代、约70个氨基酸取代至约95个氨基酸取代、约70个氨基酸取代至约90个氨基酸取代、约70个氨基酸取代至约85个氨基酸取代、约70个氨基酸取代至约80个氨基酸取代、约70个氨基酸取代至约75个氨基酸取代、约80个氨基酸取代至约160个氨基酸取代、约80个氨基酸取代至约155个氨基酸取代、约80个氨基酸取代至约150个氨基酸取代、约80个氨基酸取代至约145个氨基酸取代、约80个氨基酸取代至约140个氨基酸取代、约80个氨基酸取代至约135个氨基酸取代、约80个氨基酸取代至约130个氨基酸取代、约80个氨基酸取代至约125个氨基酸取代、约80个氨基酸取代至约120个氨基酸取代、约80个氨基酸取代至约115个氨基酸取代、约80个氨基酸取代至约110个氨基酸取代、约80个氨基酸取代至约105个氨基酸取代、约80个氨基酸取代至约100个氨基酸取代、约80个氨基酸取代至约95个氨基酸取代、约80个氨基酸取代至约90个氨基酸取代、约80个氨基酸取代至约85个氨基酸取代、约90个氨基酸取代至约160个氨基酸取代、约90个氨基酸取代至约155个氨基酸取代、约90个氨基酸取代至约150个氨基酸取代、约90个氨基酸取代至约145个氨基酸取代、约90个氨基酸取代至约140个氨基酸取代、约90个氨基酸取代至约135个氨基酸取代、约90个氨基酸取代至约130个氨基酸取代、约90个氨基酸取代至约125个氨基酸取代、约90个氨基酸取代至约120个氨基酸取代、约90个氨基酸取代至约115个氨基酸取代、约90个氨基酸取代至约110个氨基酸取代、约90个氨基酸取代至约105个氨基酸取代、约90个氨基酸取代至约100个氨基酸取代、约90个氨基酸取代至约95个氨基酸取代、约100个氨基酸取代至约160个氨基酸取代、约100个氨基酸取代至约155个氨基酸取代、约100个氨基酸取代至约150个氨基酸取代、约100个氨基酸取代至约145个氨基酸取代、约100个氨基酸取代至约140个氨基酸取代、约100个氨基酸取代至约135个氨基酸取代、约100个氨基酸取代至约130个氨基酸取代、约100个氨基酸取代至约125个氨基酸取代、约100个氨基酸取代至约120个氨基酸取代、约100个氨基酸取代至约115个氨基酸取代、约100个氨基酸取代至约110个氨基酸取代、约100个氨基酸取代至约105个氨基酸取代、约110个氨基酸取代至约160个氨基酸取代、约110个氨基酸取代至约155个氨基酸取代、约110个氨基酸取代至约150个氨基酸取代、约110个氨基酸取代至约145个氨基酸取代、约110个氨基酸取代至约140个氨基酸取代、约110个氨基酸取代至约135个氨基酸取代、约110个氨基酸取代至约130个氨基酸取代、约110个氨基酸取代至约125个氨基酸取代、约110个氨基酸取代至约120个氨基酸取代、约110个氨基酸取代至约115个氨基酸取代、约120个氨基酸取代至约160个氨基酸取代、约120个氨基酸取代至约155个氨基酸取代、约120个氨基酸取代至约150个氨基酸取代、约120个氨基酸取代至约145个氨基酸取代、约120个氨基酸取代至约140个氨基酸取代、约120个氨基酸取代至约135个氨基酸取代、约120个氨基酸取代至约130个氨基酸取代、约120个氨基酸取代至约125个氨基酸取代、约130个氨基酸取代至约160个氨基酸取代、约130个氨基酸取代至约155个氨基酸取代、约130个氨基酸取代至约150个氨基酸取代、约130个氨基酸取代至约145个氨基酸取代、约130个氨基酸取代至约140个氨基酸取代、约130个氨基酸取代至约135个氨基酸取代、约140个氨基酸取代至约160个氨基酸取代、约140个氨基酸取代至约155个氨基酸取代、约140个氨基酸取代至约150个氨基酸取代、约140个氨基酸取代至约145个氨基酸取代、约150个氨基酸取代至约160个氨基酸取代或约150个氨基酸取代至约155个氨基酸取代。本领域技术人员将理解，可对在不同物种的野生型支持细胞靶蛋白或不同物种的野生型毛细胞靶蛋白之间保守的氨基酸进行突变而不会损失活性，然而不应对在不同物种的野生型支持细胞靶蛋白或不同物种的野生型毛细胞靶蛋白之间不保守的那些氨基酸进行突变，因为它们更可能(相较于在不同物种之间不保守的氨基酸)参与活性。
活性靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)可包含野生型全长靶蛋白(例如，支持细胞靶蛋白(例如，野生型人全长支持细胞靶蛋白)或毛细胞靶蛋白(例如，野生型人全长毛细胞靶蛋白))的序列，所述野生型全长靶蛋白的序列删除了1个氨基酸至约50个氨基酸、1个氨基酸至约45个氨基酸、1个氨基酸至约40个氨基酸、1个氨基酸至约35个氨基酸、1个氨基酸至约30个氨基酸、1个氨基酸至约25个氨基酸、1个氨基酸至约20个氨基酸、1个氨基酸至约15个氨基酸、1个氨基酸至约10个氨基酸、1个氨基酸至约9个氨基酸、1个氨基酸至约8个氨基酸、1个氨基酸至约7个氨基酸、1个氨基酸至约6个氨基酸、1个氨基酸至约5个氨基酸、1个氨基酸至约4个氨基酸、1个氨基酸至约3个氨基酸、约2个氨基酸至约50个氨基酸、约2个氨基酸至约45个氨基酸、约2个氨基酸至约40个氨基酸、约2个氨基酸至约35个氨基酸、约2个氨基酸至约30个氨基酸、约2个氨基酸至约25个氨基酸、约2个氨基酸至约20个氨基酸、约2个氨基酸至约15个氨基酸、约2个氨基酸至约10个氨基酸、约2个氨基酸至约9个氨基酸、约2个氨基酸至约8个氨基酸、约2个氨基酸至约7个氨基酸、约2个氨基酸至约6个氨基酸、约2个氨基酸至约5个氨基酸、约2个氨基酸至约4个氨基酸、约3个氨基酸至约50个氨基酸、约3个氨基酸至约45个氨基酸、约3个氨基酸至约40个氨基酸、约3个氨基酸至约35个氨基酸、约3个氨基酸至约30个氨基酸、约3个氨基酸至约25个氨基酸、约3个氨基酸至约20个氨基酸、约3个氨基酸至约15个氨基酸、约3个氨基酸至约10个氨基酸、约3个氨基酸至约9个氨基酸、约3个氨基酸至约8个氨基酸、约3个氨基酸至约7个氨基酸、约3个氨基酸至约6个氨基酸、约3个氨基酸至约5个氨基酸、约4个氨基酸至约50个氨基酸、约4个氨基酸至约45个氨基酸、约4个氨基酸至约40个氨基酸、约4个氨基酸至约35个氨基酸、约4个氨基酸至约30个氨基酸、约4个氨基酸至约25个氨基酸、约4个氨基酸至约20个氨基酸、约4个氨基酸至约15个氨基酸、约4个氨基酸至约10个氨基酸、约4个氨基酸至约9个氨基酸、约4个氨基酸至约8个氨基酸、约4个氨基酸至约7个氨基酸、约4个氨基酸至约6个氨基酸、约5个氨基酸至约50个氨基酸、约5个氨基酸至约45个氨基酸、约5个氨基酸至约40个氨基酸、约5个氨基酸至约35个氨基酸、约5个氨基酸至约30个氨基酸、约5个氨基酸至约25个氨基酸、约5个氨基酸至约20个氨基酸、约5个氨基酸至约15个氨基酸、约5个氨基酸至约10个氨基酸、约5个氨基酸至约9个氨基酸、约5个氨基酸至约8个氨基酸、约5个氨基酸至约7个氨基酸、约6个氨基酸至约50个氨基酸、约6个氨基酸至约45个氨基酸、约6个氨基酸至约40个氨基酸、约6个氨基酸至约35个氨基酸、约6个氨基酸至约30个氨基酸、约6个氨基酸至约25个氨基酸、约6个氨基酸至约20个氨基酸、约6个氨基酸至约15个氨基酸、约6个氨基酸至约10个氨基酸、约6个氨基酸至约9个氨基酸、约6个氨基酸至约8个氨基酸、约7个氨基酸至约50个氨基酸、约7个氨基酸至约45个氨基酸、约7个氨基酸至约40个氨基酸、约7个氨基酸至约35个氨基酸、约7个氨基酸至约30个氨基酸、约7个氨基酸至约25个氨基酸、约7个氨基酸至约20个氨基酸、约7个氨基酸至约15个氨基酸、约7个氨基酸至约10个氨基酸、约7个氨基酸至约9个氨基酸、约8个氨基酸至约50个氨基酸、约8个氨基酸至约45个氨基酸、约8个氨基酸至约40个氨基酸、约8个氨基酸至约35个氨基酸、约8个氨基酸至约30个氨基酸、约8个氨基酸至约25个氨基酸、约8个氨基酸至约20个氨基酸、约8个氨基酸至约15个氨基酸、约8个氨基酸至约10个氨基酸、约10个氨基酸至约50个氨基酸、约10个氨基酸至约45个氨基酸、约10个氨基酸至约40个氨基酸、约10个氨基酸至约35个氨基酸、约10个氨基酸至约30个氨基酸、约10个氨基酸至约25个氨基酸、约10个氨基酸至约20个氨基酸、约10个氨基酸至约15个氨基酸、约15个氨基酸至约50个氨基酸、约15个氨基酸至约45个氨基酸、约15个氨基酸至约40个氨基酸、约15个氨基酸至约35个氨基酸、约15个氨基酸至约30个氨基酸、约15个氨基酸至约25个氨基酸、约15个氨基酸至约20个氨基酸、约20个氨基酸至约50个氨基酸、约20个氨基酸至约45个氨基酸、约20个氨基酸至约40个氨基酸、约20个氨基酸至约35个氨基酸、约20个氨基酸至约30个氨基酸、约20个氨基酸至约25个氨基酸、约25个氨基酸至约50个氨基酸、约25个氨基酸至约45个氨基酸、约25个氨基酸至约40个氨基酸、约25个氨基酸至约35个氨基酸、约25个氨基酸至约30个氨基酸、约30个氨基酸至约50个氨基酸、约30个氨基酸至约45个氨基酸、约30个氨基酸至约40个氨基酸、约30个氨基酸至约35个氨基酸、约35个氨基酸至约50个氨基酸、约35个氨基酸至约45个氨基酸、约35个氨基酸至约40个氨基酸、约40个氨基酸至约50个氨基酸、约40个氨基酸至约45个氨基酸、约45个氨基酸至约50个氨基酸。在从野生型全长毛细胞靶蛋白的序列中删除两个或更多个氨基酸的一些实施方案中，所述两个或更多个删除的氨基酸在野生型全长蛋白质的序列中可以是连续的。在从野生型全长毛细胞靶蛋白序列中删除两个或更多个氨基酸的其它实例中，所述两个或更多个删除的氨基酸在野生型全长蛋白序列中不是连续的。本领域技术人员将理解，可删除在不同物种的野生型全长毛细胞靶蛋白之间不保守的氨基酸而不会损失活性，然而不应删除在不同物种的野生型全长毛细胞靶蛋白之间保守的那些氨基酸进行突变，因为它们更可能(相较于在不同物种之间不保守的氨基酸)参与活性。
在从野生型全长支持细胞靶蛋白的序列中删除两个或更多个氨基酸的一些实施方案中，所述两个或更多个删除的氨基酸在野生型全长蛋白质的序列中可以是连续的。在从野生型全长支持细胞靶蛋白的序列中删除两个或更多个氨基酸的其它实例中，所述两个或更多个删除的氨基酸在野生型全长蛋白质的序列中不是连续的。本领域技术人员将会理解，可删除在不同物种的野生型全长支持细胞靶蛋白之间不保守的氨基酸而不会损失活性，然而不应删除在不同物种的野生型全长支持细胞靶蛋白之间保守的那些氨基酸，因为它们更有可能(相较于在不同物种之间不保守的氨基酸)参与活性。
在一些实例中，活性靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)可以例如包含野生型全长靶蛋白(例如，野生型全长支持细胞靶蛋白或野生型全长毛细胞靶蛋白)的序列，所述野生型全长靶蛋白的序列从其N末端除去了1个氨基酸至约100个氨基酸、1个氨基酸至约95个氨基酸、1个氨基酸至约90个氨基酸、1个氨基酸至约85个氨基酸、1个氨基酸至约80个氨基酸、1个氨基酸至约75个氨基酸、1个氨基酸至约70个氨基酸、1个氨基酸至约65个氨基酸、1个氨基酸至约60个氨基酸、1个氨基酸至约55个氨基酸、1个氨基酸至约50个氨基酸、1个氨基酸至约45个氨基酸、1个氨基酸至约40个氨基酸、1个氨基酸至约35个氨基酸、1个氨基酸至约30个氨基酸、1个氨基酸至约25个氨基酸、1个氨基酸至约20个氨基酸、1个氨基酸至约15个氨基酸、1个氨基酸至约10个氨基酸、1个氨基酸至约9个氨基酸、1个氨基酸至约8个氨基酸、1个氨基酸至约7个氨基酸、1个氨基酸至约6个氨基酸、1个氨基酸至约5个氨基酸、1个氨基酸至约4个氨基酸、1个氨基酸至约3个氨基酸、约2个氨基酸至约100个氨基酸、约2个氨基酸至约95个氨基酸、约2个氨基酸至约90个氨基酸、约2个氨基酸至约85个氨基酸、约2个氨基酸至约80个氨基酸、约2个氨基酸至约75个氨基酸、约2个氨基酸至约70个氨基酸、约2个氨基酸至约65个氨基酸、约2个氨基酸至约60个氨基酸、约2个氨基酸至约55个氨基酸、约2个氨基酸至约50个氨基酸、约2个氨基酸至约45个氨基酸、约2个氨基酸至约40个氨基酸、约2个氨基酸至约35个氨基酸、约2个氨基酸至约30个氨基酸、约2个氨基酸至约25个氨基酸、约2个氨基酸至约20个氨基酸、约2个氨基酸至约15个氨基酸、约2个氨基酸至约10个氨基酸、约2个氨基酸至约9个氨基酸、约2个氨基酸至约8个氨基酸、约2个氨基酸至约7个氨基酸、约2个氨基酸至约6个氨基酸、约2个氨基酸至约5个氨基酸、约2个氨基酸至约4个氨基酸、约3个氨基酸至约100个氨基酸、约3个氨基酸至约95个氨基酸、约3个氨基酸至约90个氨基酸、约3个氨基酸至约85个氨基酸、约3个氨基酸至约80个氨基酸、约3个氨基酸至约75个氨基酸、约3个氨基酸至约70个氨基酸、约3个氨基酸至约65个氨基酸、约3个氨基酸至约60个氨基酸、约3个氨基酸至约55个氨基酸、约3个氨基酸至约50个氨基酸、约3个氨基酸至约45个氨基酸、约3个氨基酸至约40个氨基酸、约3个氨基酸至约35个氨基酸、约3个氨基酸至约30个氨基酸、约3个氨基酸至约25个氨基酸、约3个氨基酸至约20个氨基酸、约3个氨基酸至约15个氨基酸、约3个氨基酸至约10个氨基酸、约3个氨基酸至约9个氨基酸、约3个氨基酸至约8个氨基酸、约3个氨基酸至约7个氨基酸、约3个氨基酸至约6个氨基酸、约3个氨基酸至约5个氨基酸、约4个氨基酸至约100个氨基酸、约4个氨基酸至约95个氨基酸、约4个氨基酸至约90个氨基酸、约4个氨基酸至约85个氨基酸、约4个氨基酸至约80个氨基酸、约4个氨基酸至约75个氨基酸、约4个氨基酸至约70个氨基酸、约4个氨基酸至约65个氨基酸、约4个氨基酸至约60个氨基酸、约4个氨基酸至约55个氨基酸、约4个氨基酸至约50个氨基酸、约4个氨基酸至约45个氨基酸、约4个氨基酸至约40个氨基酸、约4个氨基酸至约35个氨基酸、约4个氨基酸至约30个氨基酸、约4个氨基酸至约25个氨基酸、约4个氨基酸至约20个氨基酸、约4个氨基酸至约15个氨基酸、约4个氨基酸至约10个氨基酸、约4个氨基酸至约9个氨基酸、约4个氨基酸至约8个氨基酸、约4个氨基酸至约7个氨基酸、约4个氨基酸至约6个氨基酸、约5个氨基酸至约100个氨基酸、约5个氨基酸至约95个氨基酸、约5个氨基酸至约90个氨基酸、约5个氨基酸至约85个氨基酸、约5个氨基酸至约80个氨基酸、约5个氨基酸至约75个氨基酸、约5个氨基酸至约70个氨基酸、约5个氨基酸至约65个氨基酸、约5个氨基酸至约60个氨基酸、约5个氨基酸至约55个氨基酸、约5个氨基酸至约50个氨基酸、约5个氨基酸至约45个氨基酸、约5个氨基酸至约40个氨基酸、约5个氨基酸至约35个氨基酸、约5个氨基酸至约30个氨基酸、约5个氨基酸至约25个氨基酸、约5个氨基酸至约20个氨基酸、约5个氨基酸至约15个氨基酸、约5个氨基酸至约10个氨基酸、约5个氨基酸至约9个氨基酸、约5个氨基酸至约8个氨基酸、约5个氨基酸至约7个氨基酸、约6个氨基酸至约100个氨基酸、约6个氨基酸至约95个氨基酸、约6个氨基酸至约90个氨基酸、约6个氨基酸至约85个氨基酸、约6个氨基酸至约80个氨基酸、约6个氨基酸至约75个氨基酸、约6个氨基酸至约70个氨基酸、约6个氨基酸至约65个氨基酸、约6个氨基酸至约60个氨基酸、约6个氨基酸至约55个氨基酸、约6个氨基酸至约50个氨基酸、约6个氨基酸至约45个氨基酸、约6个氨基酸至约40个氨基酸、约6个氨基酸至约35个氨基酸、约6个氨基酸至约30个氨基酸、约6个氨基酸至约25个氨基酸、约6个氨基酸至约20个氨基酸、约6个氨基酸至约15个氨基酸、约6个氨基酸至约10个氨基酸、约6个氨基酸至约9个氨基酸、约6个氨基酸至约8个氨基酸、约7个氨基酸至约100个氨基酸、约7个氨基酸至约95个氨基酸、约7个氨基酸至约90个氨基酸、约7个氨基酸至约85个氨基酸、约7个氨基酸至约80个氨基酸、约7个氨基酸至约75个氨基酸、约7个氨基酸至约70个氨基酸、约7个氨基酸至约65个氨基酸、约7个氨基酸至约60个氨基酸、约7个氨基酸至约55个氨基酸、约7个氨基酸至约50个氨基酸、约7个氨基酸至约45个氨基酸、约7个氨基酸至约40个氨基酸、约7个氨基酸至约35个氨基酸、约7个氨基酸至约30个氨基酸、约7个氨基酸至约25个氨基酸、约7个氨基酸至约20个氨基酸、约7个氨基酸至约15个氨基酸、约7个氨基酸至约10个氨基酸、约7个氨基酸至约9个氨基酸、约8个氨基酸至约100个氨基酸、约8个氨基酸至约95个氨基酸、约8个氨基酸至约90个氨基酸、约8个氨基酸至约85个氨基酸、约8个氨基酸至约80个氨基酸、约8个氨基酸至约75个氨基酸、约8个氨基酸至约70个氨基酸、约8个氨基酸至约65个氨基酸、约8个氨基酸至约60个氨基酸、约8个氨基酸至约55个氨基酸、约8个氨基酸至约50个氨基酸、约8个氨基酸至约45个氨基酸、约8个氨基酸至约40个氨基酸、约8个氨基酸至约35个氨基酸、约8个氨基酸至约30个氨基酸、约8个氨基酸至约25个氨基酸、约8个氨基酸至约20个氨基酸、约8个氨基酸至约15个氨基酸、约8个氨基酸至约10个氨基酸、约10个氨基酸至约100个氨基酸、约10个氨基酸至约95个氨基酸、约10个氨基酸至约90个氨基酸、约10个氨基酸至约85个氨基酸、约10个氨基酸至约80个氨基酸、约10个氨基酸至约75个氨基酸、约10个氨基酸至约70个氨基酸、约10个氨基酸至约65个氨基酸、约10个氨基酸至约60个氨基酸、约10个氨基酸至约55个氨基酸、约10个氨基酸至约50个氨基酸、约10个氨基酸至约45个氨基酸、约10个氨基酸至约40个氨基酸、约10个氨基酸至约35个氨基酸、约10个氨基酸至约30个氨基酸、约10个氨基酸至约25个氨基酸、约10个氨基酸至约20个氨基酸、约10个氨基酸至约15个氨基酸、约20个氨基酸至约100个氨基酸、约20个氨基酸至约95个氨基酸、约20个氨基酸至约90个氨基酸、约20个氨基酸至约85个氨基酸、约20个氨基酸至约80个氨基酸、约20个氨基酸至约75个氨基酸、约20个氨基酸至约70个氨基酸、约20个氨基酸至约65个氨基酸、约20个氨基酸至约60个氨基酸、约20个氨基酸至约55个氨基酸、约20个氨基酸至约50个氨基酸、约20个氨基酸至约45个氨基酸、约20个氨基酸至约40个氨基酸、约20个氨基酸至约35个氨基酸、约20个氨基酸至约30个氨基酸、约20个氨基酸至约25个氨基酸、约30个氨基酸至约100个氨基酸、约30个氨基酸至约95个氨基酸、约30个氨基酸至约90个氨基酸、约30个氨基酸至约85个氨基酸、约30个氨基酸至约80个氨基酸、约30个氨基酸至约75个氨基酸、约30个氨基酸至约70个氨基酸、约30个氨基酸至约65个氨基酸、约30个氨基酸至约60个氨基酸、约30个氨基酸至约55个氨基酸、约30个氨基酸至约50个氨基酸、约30个氨基酸至约45个氨基酸、约30个氨基酸至约40个氨基酸、约30个氨基酸至约35个氨基酸、约40个氨基酸至约100个氨基酸、约40个氨基酸至约95个氨基酸、约40个氨基酸至约90个氨基酸、约40个氨基酸至约85个氨基酸、约40个氨基酸至约80个氨基酸、约40个氨基酸至约75个氨基酸、约40个氨基酸至约70个氨基酸、约40个氨基酸至约65个氨基酸、约40个氨基酸至约60个氨基酸、约40个氨基酸至约55个氨基酸、约40个氨基酸至约50个氨基酸、约40个氨基酸至约45个氨基酸、约50个氨基酸至约100个氨基酸、约50个氨基酸至约95个氨基酸、约50个氨基酸至约90个氨基酸、约50个氨基酸至约85个氨基酸、约50个氨基酸至约80个氨基酸、约50个氨基酸至约75个氨基酸、约50个氨基酸至约70个氨基酸、约50个氨基酸至约65个氨基酸、约50个氨基酸至约60个氨基酸、约50个氨基酸至约55个氨基酸、约60个氨基酸至约100个氨基酸、约60个氨基酸至约95个氨基酸、约60个氨基酸至约90个氨基酸、约60个氨基酸至约85个氨基酸、约60个氨基酸至约80个氨基酸、约60个氨基酸至约75个氨基酸、约60个氨基酸至约70个氨基酸、约60个氨基酸至约65个氨基酸、约70个氨基酸至约100个氨基酸、约70个氨基酸至约95个氨基酸、约70个氨基酸至约90个氨基酸、约70个氨基酸至约85个氨基酸、约70个氨基酸至约80个氨基酸、约70个氨基酸至约75个氨基酸、约80个氨基酸至约100个氨基酸、约80个氨基酸至约95个氨基酸、约80个氨基酸至约90个氨基酸、约80个氨基酸至约85个氨基酸、约90个氨基酸至约100个氨基酸、约90个氨基酸至约95个氨基酸或约95个氨基酸至约100个氨基酸并且/或者从其C末端除去了1个氨基酸至100个氨基酸(或本文所述的该范围的任何子范围)。
在一些实施方案中，活性靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)可以例如包括野生型全长靶蛋白(例如，野生型全长支持细胞靶蛋白或野生型全长毛细胞靶蛋白)的序列，在所述野生型全长靶蛋白的序列中插入了1个氨基酸至50个氨基酸、1个氨基酸至45个氨基酸、1个氨基酸至40个氨基酸、1个氨基酸至35个氨基酸、1个氨基酸至30个氨基酸、1个氨基酸至25个氨基酸、1个氨基酸至20个氨基酸、1个氨基酸至15个氨基酸、1个氨基酸至10个氨基酸、1个氨基酸至9个氨基酸、1个氨基酸至8个氨基酸、1个氨基酸至7个氨基酸、1个氨基酸至6个氨基酸、1个氨基酸至5个氨基酸、1个氨基酸至4个氨基酸、1个氨基酸至3个氨基酸、约2个氨基酸至50个氨基酸、约2个氨基酸至45个氨基酸、约2个氨基酸至40个氨基酸、约2个氨基酸至35个氨基酸、约2个氨基酸至30个氨基酸、约2个氨基酸至25个氨基酸、约2个氨基酸至20个氨基酸、约2个氨基酸至15个氨基酸、约2个氨基酸至10个氨基酸、约2个氨基酸至9个氨基酸、约2个氨基酸至8个氨基酸、约2个氨基酸至7个氨基酸、约2个氨基酸至6个氨基酸、约2个氨基酸至5个氨基酸、约2个氨基酸至4个氨基酸、约3个氨基酸至50个氨基酸、约3个氨基酸至45个氨基酸、约3个氨基酸至40个氨基酸、约3个氨基酸至35个氨基酸、约3个氨基酸至30个氨基酸、约3个氨基酸至25个氨基酸、约3个氨基酸至20个氨基酸、约3个氨基酸至15个氨基酸、约3个氨基酸至10个氨基酸、约3个氨基酸至9个氨基酸、约3个氨基酸至8个氨基酸、约3个氨基酸至7个氨基酸、约3个氨基酸至6个氨基酸、约3个氨基酸至5个氨基酸、约4个氨基酸至50个氨基酸、约4个氨基酸至45个氨基酸、约4个氨基酸至40个氨基酸、约4个氨基酸至35个氨基酸、约4个氨基酸至30个氨基酸、约4个氨基酸至25个氨基酸、约4个氨基酸至20个氨基酸、约4个氨基酸至15个氨基酸、约4个氨基酸至10个氨基酸、约4个氨基酸至9个氨基酸、约4个氨基酸至8个氨基酸、约4个氨基酸至7个氨基酸、约4个氨基酸至6个氨基酸、约5个氨基酸至50个氨基酸、约5个氨基酸至45个氨基酸、约5个氨基酸至40个氨基酸、约5个氨基酸至35个氨基酸、约5个氨基酸至30个氨基酸、约5个氨基酸至25个氨基酸、约5个氨基酸至20个氨基酸、约5个氨基酸至15个氨基酸、约5个氨基酸至10个氨基酸、约5个氨基酸至9个氨基酸、约5个氨基酸至8个氨基酸、约5个氨基酸至7个氨基酸、约6个氨基酸至50个氨基酸、约6个氨基酸至45个氨基酸、约6个氨基酸至40个氨基酸、约6个氨基酸至35个氨基酸、约6个氨基酸至30个氨基酸、约6个氨基酸至25个氨基酸、约6个氨基酸至20个氨基酸、约6个氨基酸至15个氨基酸、约6个氨基酸至10个氨基酸、约6个氨基酸至9个氨基酸、约6个氨基酸至8个氨基酸、约7个氨基酸至50个氨基酸、约7个氨基酸至45个氨基酸、约7个氨基酸至40个氨基酸、约7个氨基酸至35个氨基酸、约7个氨基酸至30个氨基酸、约7个氨基酸至25个氨基酸、约7个氨基酸至20个氨基酸、约7个氨基酸至15个氨基酸、约7个氨基酸至10个氨基酸、约7个氨基酸至9个氨基酸、约8个氨基酸至50个氨基酸、约8个氨基酸至45个氨基酸、约8个氨基酸至40个氨基酸、约8个氨基酸至35个氨基酸、约8个氨基酸至30个氨基酸、约8个氨基酸至25个氨基酸、约8个氨基酸至20个氨基酸、约8个氨基酸至15个氨基酸、约8个氨基酸至10个氨基酸、约10个氨基酸至50个氨基酸、约10个氨基酸至45个氨基酸、约10个氨基酸至40个氨基酸、约10个氨基酸至35个氨基酸、约10个氨基酸至30个氨基酸、约10个氨基酸至25个氨基酸、约10个氨基酸至20个氨基酸、约10个氨基酸至15个氨基酸、约15个氨基酸至50个氨基酸、约15个氨基酸至45个氨基酸、约15个氨基酸至40个氨基酸、约15个氨基酸至35个氨基酸、约15个氨基酸至30个氨基酸、约15个氨基酸至25个氨基酸、约15个氨基酸至20个氨基酸、约20个氨基酸至50个氨基酸、约20个氨基酸至45个氨基酸、约20个氨基酸至40个氨基酸、约20个氨基酸至35个氨基酸、约20个氨基酸至30个氨基酸、约20个氨基酸至25个氨基酸、约25个氨基酸至50个氨基酸、约25个氨基酸至45个氨基酸、约25个氨基酸至40个氨基酸、约25个氨基酸至35个氨基酸、约25个氨基酸至30个氨基酸、约30个氨基酸至50个氨基酸、约30个氨基酸至45个氨基酸、约30个氨基酸至40个氨基酸、约30个氨基酸至35个氨基酸、约35个氨基酸至50个氨基酸、约35个氨基酸至45个氨基酸、约35个氨基酸至40个氨基酸、约40个氨基酸至50个氨基酸、约40个氨基酸至45个氨基酸或约45个氨基酸至约50个氨基酸。在一些实例中，可以将1个氨基酸至50个氨基酸(或其任何子范围)作为连续序列插入野生型全长蛋白质的序列中。在一些实例中，不将1个氨基酸至50个氨基酸(或其任何子范围)作为连续序列插入野生型全长蛋白质的序列中。如本领域中可以理解的，可以将1个氨基酸至50个氨基酸插入野生型全长蛋白质的序列的一部分中，所述野生型全长蛋白质在物种之间不是非常保守的。
除非另有限定，否则本文中所使用的所有技术和科学术语具有与本发明所属的领域内的普通技术人员通常理解的意义相同的意义。本文描述了用于本发明的方法和材料；还可使用本领域已知的其他合适的方法和材料。所述材料、方法和实例仅是说明性的而不是意图进行限制。本文引用的所有公布、专利申请、专利、序列、数据库条目和其它参考文献通过引用以其整体并入本文。在有冲突的情况下，将以本说明书(包括定义)为准。
附图说明
图1A是在通过圆形窗口将单个Anc80-GFP AAV载体直接施用于内耳后，食蟹猕猴(非人灵长类动物)的耳蜗组织的Myo7a/Iba-1免疫荧光染色的代表性图像。
图1B是与图1A中相同的食蟹猕猴的耳蜗组织的Anc80-GFP免疫荧光染色的代表性图像。
图1C是与图1A中相同的食蟹猕猴的耳蜗组织的Myo7a/Iba-1和Anc80-GFP的合并的免疫荧光染色的代表性图像。
具体实施方式
本文提供了包含至少两种不同的核酸载体的组合物，其中：所述至少两种不同的腺相关病毒(AAV)载体中的每一种均包含编码序列，所述编码序列编码支持细胞靶蛋白的不同部分，所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；所述至少两种不同的载体中单一载体均不编码全长支持细胞靶蛋白；所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列；以及所述至少两种不同的载体，当被引入到灵长类动物细胞中时，经历彼此串联或同源重组，从而形成编码全长支持细胞靶蛋白的重组核酸。
本文提供了包含两种不同的核酸载体的组合物，其中：所述两种不同的核酸载体中的第一核酸载体包含启动子、位于所述启动子的3’的编码支持细胞靶蛋白的N末端部分的第一编码序列和位于所述第一编码序列的3’末端的剪接供体信号序列；以及所述两种不同的核酸载体中的第二核酸载体包含剪接受体信号序列、位于所述剪接受体信号序列的3'末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多聚腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的氨基酸序列不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。
本文提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3'的编码支持细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列，和位于所述剪接供体信号序列的3’的第一可检测标记基因；和第二核酸载体，其与所述第一核酸载体不同，包含第二可检测标记基因、位于所述第二可检测标记基因的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。
本文还提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3'的编码支持细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列，和位于所述剪接供体信号序列的3’的F1噬菌体重组发生区；和第二核酸载体，其与所述第一核酸载体不同，包含第二F1噬菌体重组发生区、位于所述第二F1噬菌体重组发生区的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。
本文提供了包含单一腺相关病毒(AAV)载体的组合物，其中所述单一AAV载体包含编码支持细胞靶蛋白的核酸序列；以及当被引入到灵长类动物细胞中时，在支持细胞靶基因的基因座处产生编码全长支持细胞靶蛋白的核酸，并且所述灵长类动物表达所述支持细胞靶蛋白。
本文提供了包含至少两种不同的核酸载体的组合物，其中：所述至少两种不同的腺相关病毒(AAV)载体中的每一种均包含编码序列，所述编码序列编码毛细胞靶蛋白的不同部分，所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；所述至少两种不同的载体中单一载体均不编码全长毛细胞靶蛋白；所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列；以及所述至少两种不同的载体，当被引入到灵长类动物细胞中时，经历彼此串联或同源重组，从而形成编码全长毛细胞靶蛋白的重组核酸。
本文提供了包含两种不同的核酸载体的组合物，其中：所述两种不同的核酸载体中的第一核酸载体包含启动子、位于所述启动子的3’的编码毛细胞靶蛋白的N末端部分的第一编码序列和位于所述第一编码序列的3’末端的剪接供体信号序列；以及所述两种不同的核酸载体中的第二核酸载体包含剪接受体信号序列、位于所述剪接受体信号序列的3'末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多聚腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的氨基酸序列不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。
本文提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3’的编码毛细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列，和位于所述剪接供体信号序列的3’的第一可检测标记基因；和第二核酸载体，其与所述第一核酸载体不同，包含第二可检测标记基因、位于所述第二可检测标记基因的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。
本文提供了组合物，其包含：第一核酸载体，其包含启动子、位于所述启动子的3’的编码毛细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列和位于所述剪接供体信号序列的3’的F1噬菌体重组发生区；和第二核酸载体，其与所述第一核酸载体不同，包含第二F1噬菌体重组发生区、位于所述第二F1噬菌体重组发生区的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的剪接供体信号与另一个转录物上的剪接受体信号之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。
本文还提供了包含单一腺相关病毒(AAV)载体的组合物，其中所述单一AAV载体包含编码毛细胞靶蛋白的核酸序列；并且当被引入到灵长类动物细胞时，在所述毛细胞靶基因的基因座处产生编码全长毛细胞靶蛋白的核酸，并且所述灵长类动物表达所述毛细胞靶蛋白。
还提供了包括本文所述的任何组合物的试剂盒。本文还提供了包括向哺乳动物的耳蜗施用治疗有效量的本文所述的任何组合物的方法。
还提供了校正灵长类动物内耳的支持细胞中的支持细胞靶基因缺陷的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用修复所述灵长类动物内耳的支持细胞中的支持细胞靶基因缺陷。
还提供了校正灵长类动物内耳的毛细胞中的毛细胞靶基因缺陷的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用修复所述灵长类动物内耳的毛细胞中的毛细胞靶基因缺陷。
本文还提供了升高灵长类动物内耳的支持细胞中的支持细胞靶蛋白的表达水平的方法，所述方法包括向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用使得所述灵长类动物内耳的支持细胞中的所述支持细胞靶蛋白的表达水平升高。
本文还提供了升高灵长类动物内耳的毛细胞中的毛细胞靶蛋白的表达水平的方法，所述方法包括向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用使得所述灵长类动物内耳的所述毛细胞中的所述毛细胞靶蛋白的表达水平升高。
本文还提供了治疗被鉴定为具有缺陷型支持细胞靶基因的灵长类动物的听力损失，例如非综合征性感音神经性听力损失或综合征性感音神经性听力损失的方法，所述方法包括：向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。
本文还提供了治疗被鉴定为具有缺陷型毛细胞靶基因的灵长类动物的听力损失(例如非综合征性感音神经性听力损失或综合征性感音神经性听力损失)的方法，所述方法包括：向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。
本文还提供了恢复被鉴定或诊断为听力损失的灵长类动物的听力的方法，所述方法包括：向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。
本文还提供了恢复被鉴定或诊断为患有内耳病症的灵长类动物的突触并且/或者保存其螺旋神经节神经的方法，所述方法包括：向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。
本文还提供了包括向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物的方法。
组合物、试剂盒和方法的其它非限制性方面在本文中进行了描述，并且可以以任意组合使用而不受限制。
缝隙连接蛋白β2(GJB2)
GJB2基因编码缝隙连接蛋白β2(缝隙连接蛋白家族的成员)。缝隙连接蛋白是参与细胞内通讯的专门蛋白，也称为连结蛋白。GJB2中的突变已与听力损失和耳聋相关联(Amorini等人，Ann.Hum.Genet.79(5):341-349,2015；Qing等人，Genet.TestMol.Biomarkers 19(1):52-58,2015)。
人GJB2基因位于染色体13q12上。其包含2个外显子，涵盖约5千碱基(kb)(NCBI登录号NG008358.1)。从人GJB2基因表达的全长野生型GJB2蛋白的长度为226个氨基酸。
GJB2基因中的各种突变与听力损失(例如，非综合征性感音神经性听力损失或综合征性感音神经性听力损失)相关联。例如，在65.5％的来自西西里岛东部的患者中发现c.35delG等位基因(Amorini等人，Ann.Hum.Genet.79(5):341-349,2015)。
在患有非综合征性感音神经性听力损失或综合征性感音神经性听力损失的受试者中检测到的GJB2基因中的其它示例性突变，以及对编码GJB2的核酸进行测序的方法描述于例如Snoeckx等人，Am.J.Hum.Genet 77:945-957,2005；Welch等人，Am.J.Med.Genet A143:1567-1573,2007；和Zelante等人，Hum.Mol.Genet.6:1605-1609,1997中。检测基因中的突变的方法是本领域公知的。此类技术的非限制性实例包括：实时聚合酶链式反应(RT-PCR)、PCR、测序、Southern印迹和Northern印迹。
示例性人野生型GJB2蛋白为或包括SEQ ID NO:1的序列。编码野生型GJB2蛋白的核酸的非限制性实例为或包括SEQ ID NO:2。如在本领域中可以理解的，可对SEQ ID NO:2中的至少一些或全部密码子进行密码子优化以允许在非人哺乳动物中的最佳表达。
在本文所述的任何组合物的一些实施方案中，GJB2蛋白包含与SEQ ID NO:1具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
人全长野生型GJB2蛋白(SEQ ID NO:1)
MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRHEKKRKFIKGEIKSEFKDIEEIKTQKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDGFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYCSGKSKKPV
人野生型GJB2 cDNA(SEQ ID NO:2)
atggattggggcacgctgcagacgatcctggggggtgtgaacaaacactccaccagcattggaaagatctggctcaccgtcctcttcatttttcgcattatgatcctcgttgtggctgcaaaggaggtgtggggagatgagcaggccgactttgtctgcaacaccctgcagccaggctgcaagaacgtgtgctacgatcactacttccccatctcccacatccggctatgggccctgcagctgatcttcgtgtccacgccagcgctcctagtggccatgcacgtggcctaccggagacatgagaagaagaggaagttcatcaagggggagataaagagtgaatttaaggacatcgaggagatcaaaacccagaaggtccgcatcgaaggctccctgtggtggacctacacaagcagcatcttcttccgggtcatcttcgaagccgccttcatgtacgtcttctatgtcatgtacgacggcttctccatgcagcggctggtgaagtgcaacgcctggccttgtcccaacactgtggactgctttgtgtcccggcccacggagaagactgtcttcacagtgttcatgattgcagtgtctggaatttgcatcctgctgaatgtcactgaattgtgttatttgctaattagatattgttctgggaagtcaaaaaagccagtttaa
人野生型GJB2基因组DNA序列的非限制性实例是SEQ ID NO:3。SEQ ID NO:3中的外显子是：核苷酸位置1-156(外显子1)和核苷酸位置3336-5469(外显子2)。内含子位于SEQID NO:3中的这些外显子中的每一个之间，即，在核苷酸位置157-3335处(内含子1)。
人野生型GJB2基因序列(SEQ ID NO:3)(NCBI参考序列：NG_008358.1)
1 ggggtgcggt taaaaggcgc cacggcggga gacaggtgtt gcggccccgc agcgcccgcg61cgctcctctc cccgactcgg agcccctcgg cggcgcccgg cccaggaccc gcctaggagc 121gcaggagccc cagcgcagag accccaacgc cgagaccccc gccccggccc cgccgcgctt 181cctcccgacg caggtgagcc cgccggcccc ggactgcccg gccaggaacc tggcgcgggg 241agggaccgcg agacccagag cggttgcccg gccgcgtggg tctcggggaa ccggggggct 301ggaccaacac acgtccttgg gccggggggc gggggccgcc ttctggagcg ggcgtttctg 361cggccgagct ccggagctgg aatggggcgg ccggggaagt ggacgcgatg gcaccgcccg 421gggtgcgagt ggggccgggc gcgcgcggga ggggaaaaag gcgcgggcga gccgccagcg 481cgaggtttgt ggtgtcgccg atgtcccttc ggggtactct agcgcagccg cctggctact 541tgacccactg ccaccaaacg ttttaaattc accgaaagct tagcttcgaa gcaaagctcc 601gtttcgccgg tgaagcagga agccttcgct gcaggaactg acctttacct cttggagcgg 661cttctgcaga aaaatccccg ggcagagatt tgggcggagt ttgcctagaa ctaacgcgga 721gccagccgat cccggcctac cccggggcca agatttcagt ggcttccctt tttcctaaac 781acttcacgag ggtctgtttc cgggctgtgc tccccgccta gaaggaaaat ttttaggacc 841cttgttcgcg aagaggtggt gtgcggctga gacccgcgtc ctcaggacgg ttccatcagt 901gcctcgatcc tgccccactg gaggaggaag gcagcccgaa cagcgctcac ctaactaaca 961gctgctgaga gctgggttcc gtggccatgc acctgggact gccttgagaa gcgtggtacg 1021gccgtgtccc catgtgacct tagagtccct ttcgaaactg ctgtgcacag tcggtcacaa 1081tttcagacac tggtgagaag ggtggaggaa ccctctgggg acagccaggc aaggtcgacc 1141acccatcacc taagggtgga gaaatttaag gggtgaagag tcccttttgc cttttctgga 1201tcctggtgat tcacctagtg tcttccctaa ggaactgaac caactcctcc gctggcctct 1261ggcagccctc caggcggtgc aggatggcgt gggcccggta ggaagctgca tgtaaccgcc 1321cagggtcggg aggccaggag ggcagctcct cctctgactt gaatattgaa aacaacttcg 1381tcctgcttct gagcccctct taacccatga ccccctagcc cattggggag taaatcttaa 1441tttactcctc ttcctgaaaa aggatcttta aaacaggtag cttcaactca agctttataa 1501aataacaata tagggtttct cggaactgta tttttctcag ctgatggtaa ctggacaggt 1561ctgtagaagg gtgtatgacc tgggtttggc aggtggaaga gggcaaagga taaacccctc 1621ctcctgcagc cccatattct tggccaggtg tattgttgta aaccaggaga gagtttactt 1681cggggagtat cctgttttcc actcagtgag ggccaatgaa gaatgtctaa ttccataaga 1741tgcttttgtt aaaatcggaa tgttgctgtc ctcggtggtt ctgctgttgg gacgggactg 1801gcctgagctg tgggtgctgt agcaggacaa ccagctcacc taagggcctc ccagtctgga 1861ttatcaatgg gtcagtgctg aacctgggct aaaatattgt tttttccaat gatgttgtct 1921ttcccaagct cagtgaagct aaatgtttca caggcctatg tcaatctgat gtaactttcg 1981tggccacctc tctcctgtta gcctctgacc aaggtggcac tggatggttt ctgcctgacc 2041ttggtgcccc gtggcagcga ctgtgggtca tgaaagacat tcactacgag cctgcttctg 2101gagtccatca gaaaacggga tgcaacttgc ctaaaatgag gagaggagga tgcttttaag 2161aaaaagaaga aggaggattc actaccagct ctgaagggtg gaaaagagat gattcatccg 2221gattgtggag agggtggaat cttgtttagg agagcgttgg ttgtggcagg cagggtgtaa 2281ctatgaatca gtgaagacaa ttcacatcct gggatgaaaa gaaggccatg ggctcacagg 2341agattatcca ctggcctctc cacatccgct tgcagtaagg agtgtgggac tctcccaagc 2401ttcagcgctg aactgcaatg cagtgacgtc gcttagctgg gccagtaacc gagggagttg 2461aattttctgt cattttaaaa taatgtgtct tttaagaaac actttgaaat taaaaccaca 2521gcccacaatt ataatgcact gttgcagcac ttatcaaaac agatatgcta actgagccat 2581cagtgccagc ctgacagtga ggccaccaag ccatccacaa agcctacacg aaagtctgtg 2641ctcacagtgg cttttctcca tgaagagggc attcctaacc tcttcctttc acgtaggagg 2701aagcaaggtc ctttgtaaaa ttttaactcg gggtgcctca aatgtaaact taaccactgg 2761taacaacagt ttcactgcta catgccacgt ctgtgaaaat tcattcaaga cattaaggaa 2821agtggctcag cagagagact agacatctta tcctcacggt tctcctgtac ttggcctctc 2881agcctttgag caaggttggc ccaagctagt atcggcccca gtggtacagc caaaacttga 2941gactgcaaat ggatgcagct gttgaacgct gagtaacttc tgcagagtca ggaagaccca 3001aggaagctct gcagaggatg caggggtacg gtcagaaccc ctgagtgcct ttcagctaac 3061gaggacttta tgacactccc cagcacagca aatttttatg atgtgtttaa agattgggtg 3121aattactcag gtgaacaagc tactttttat cagagaacac ctaaaaacac gttcaagagg 3181gtttgggaac tatacattta atcctatgac aaactaagtt ggttctgtct tcacctgttt 3241tggtgaggtt gtgtaagagt tggtgtttgc tcaggaagag atttaagcat gcttgcttac 3301ccagactcag agaagtctcc ctgttctgtc ctagctagtg attcctgtgt tgtgtgcatt 3361cgtcttttcc agagcaaacc gcccagagta gaagatggat tggggcacgc tgcagacgat 3421cctggggggt gtgaacaaac actccaccag cattggaaag atctggctca ccgtcctctt 3481catttttcgc attatgatcc tcgttgtggc tgcaaaggag gtgtggggag atgagcaggc 3541cgactttgtc tgcaacaccc tgcagccagg ctgcaagaac gtgtgctacg atcactactt 3601ccccatctcc cacatccggc tatgggccct gcagctgatc ttcgtgtcca cgccagcgct 3661cctagtggcc atgcacgtgg cctaccggag acatgagaag aagaggaagt tcatcaaggg 3721ggagataaag agtgaattta aggacatcga ggagatcaaa acccagaagg tccgcatcga 3781aggctccctg tggtggacct acacaagcag catcttcttc cgggtcatct tcgaagccgc 3841cttcatgtac gtcttctatg tcatgtacga cggcttctcc atgcagcggc tggtgaagtg 3901caacgcctgg ccttgtccca acactgtgga ctgctttgtg tcccggccca cggagaagac 3961tgtcttcaca gtgttcatga ttgcagtgtc tggaatttgc atcctgctga atgtcactga 4021attgtgttat ttgctaatta gatattgttc tgggaagtca aaaaagccag tttaacgcat 4081tgcccagttg ttagattaag aaatagacag catgagaggg atgaggcaac ccgtgctcag 4141ctgtcaaggc tcagtcgcta gcatttccca acacaaagat tctgacctta aatgcaacca 4201tttgaaaccc ctgtaggcct caggtgaaac tccagatgcc acaatggagc tctgctcccc 4261taaagcctca aaacaaaggc ctaattctat gcctgtctta attttctttc acttaagtta 4321gttccactga gaccccaggc tgttaggggt tattggtgta aggtactttc atattttaaa 4381cagaggatat cggcatttgt ttctttctct gaggacaaga gaaaaaagcc aggttccaca 4441gaggacacag agaaggtttg ggtgtcctcc tggggttctt tttgccaact ttccccacgt 4501taaaggtgaa cattggttct ttcatttgct ttggaagttt taatctctaa cagtggacaa 4561agttaccagt gccttaaact ctgttacact ttttggaagt gaaaactttg tagtatgata 4621ggttattttg atgtaaagat gttctggata ccattatatg ttccccctgt ttcagaggct 4681cagattgtaa tatgtaaatg gtatgtcatt cgctactatg atttaatttg aaatatggtc 4741ttttggttat gaatactttg cagcacagct gagaggctgt ctgttgtatt cattgtggtc 4801atagcaccta acaacattgt agcctcaatc gagtgagaca gactagaagt tcctagtgat 4861ggcttatgat agcaaatggc ctcatgtcaa atatttagat gtaattttgt gtaagaaata 4921cagactggat gtaccaccaa ctactacctg taatgacagg cctgtccaac acatctccct 4981tttccatgac tgtggtagcc agcatcggaa agaacgctga tttaaagagg tcgcttggga 5041attttattga cacagtacca tttaatgggg aggacaaaat ggggcagggg agggagaagt 5101ttctgtcgtt aaaaacagat ttggaaagac tggactctaa agtctgttga ttaaagatga 5161gctttgtcta cttcaaaagt ttgtttgctt accccttcag cctccaattt tttaagtgaa 5221aatatagcta ataacatgtg aaaagaatag aagctaaggt ttagataaat attgagcaga 5281tctataggaa gattgaacct gaatattgcc attatgcttg acatggtttc caaaaaatgg 5341tactccacat atttcagtga gggtaagtat tttcctgttg tcaagaatag cattgtaaaa 5401gcattttgta ataataaaga atagctttaa tgatatgctt gtaactaaaa taattttgta 5461atgtatcaaa tacatttaaa acattaaaat ataatctcta taataattta aaa
溶质载体家族26成员4(SLC26A4)
SLC26A4基因编码Pendred蛋白，并且与硫酸盐转运蛋白具有同源性。SLC26A4中的突变与听力损失和耳聋相关联(Albert等人，Eur.J.Hum.Genet.14:773-779,2006；和Qing等人，Genet.Test Mol.Biomarkers 19(1):52-58,2015)。
人SLC26A4基因位于染色体7q22上。其包含21个外显子，涵盖约57千碱基(kb)(NCBI登录号NG_008489.1)。从人SLC26A4基因表达的全长野生型SLC26A4蛋白的长度为780个氨基酸。
SLC26A4基因的各种突变与听力损失相关联。例如，在患有非综合征性听力损失的中国和美国患者中，已经报道了点突变V250A、D266N、E303Q、F345S、D697、K715N和E737D(Dai等人，Physiol Genomics 38(3):281-290,2015)。
在患有非综合征性感音神经性听力损失或综合征性感音神经性听力损失的受试者中检测到的SLC26A4基因的其它示例性突变，以及对编码SLC26A4的核酸进行测序的方法描述于例如Albert等人，Eur.J.Hum.Genet.14:773-779,2006；和Qing等人，Genet.TestMol.Biomarkers 19(1):52-58,2015中。检测基因中的突变的方法是本领域公知的。此类技术的非限制性实例包括：实时聚合酶链式反应(RT-PCR)、PCR、测序、Southern印迹和Northern印迹。
示例性人野生型SLC26A4蛋白为或包括SEQ ID NO:4的序列。编码野生型SLC26A4蛋白的核酸的非限制性实例为或包括SEQ ID NO:5或6.如在本领域中可理解的，可对SEQID NO:5或6中的至少一些或全部密码子进行密码子优化以允许在非人哺乳动物中的最佳表达。
在本文所述的任何组合物的一些实施方案中，所述SLC26A4蛋白包含与SEQ IDNO:4具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
人全长野生型SLC26A4蛋白(SEQ ID NO:4)
MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS
示例性人野生型SLC26A4 cDNA(SEQ ID NO:5)
atggcagcgccaggcggcaggtcggagccgccgcagctccccgagtacagctgcagctacatggtgtcgcggccggtctacagcgagctcgctttccagcaacagcacgagcggcgcctgcaggagcgcaagacgctgcgggagagcctggccaagtgctgcagttgttcaagaaagagagcctttggtgtgctaaagactcttgtgcccatcttggagtggctccccaaataccgagtcaaggaatggctgcttagtgacgtcatttcgggagttagtactgggctagtggccacgctgcaagggatggcatatgccctactagctgcagttcctgtcggatatggtctctactctgcttttttccctatcctgacatactttatctttggaacatcaagacatatctcagttggaccttttcca
gtggtgagtttaatggtgggatctgttgttctgagcatggcccccgacgaacactttctcgtatccagcagcaatggaactgtattaaatactactatgatagacactgcagctagagatacagctagagtcctgattgccagtgccctgactctgctggttggaattatacagttgatatttggtggcttgcagattggattcatagtgaggtacttggcagatcctttggttggtggcttcacaacagctgctgccttccaagtgctggtctcacagctaaagattgtcctcaatgtttcaaccaaaaactacaatggagttctctctattatctatacgctggttgagatttttcaaaatattggtgataccaatcttgctgatttcactgctggattgctcaccattgtcgtctgtatggcagttaaggaattaaatgatcggtttagacacaaaatcccagtccctattcctatagaagtaattgtgacgataattgctactgccatttcatatggagccaacctggaaaaaaattacaatgctggcattgttaaatccatcccaagggggtttttgcctcctgaacttccacctgtgagcttgttctcggagatgctggctgcatcattttccatcgctgtggtggcttatgctattgcagtgtcagtaggaaaagtatatgccaccaagtatgattacaccatcgatgggaaccaggaattcattgcctttgggatcagcaacatcttctcaggattcttctcttgttttgtg
gccaccactgctctttcccgcacggccgtccaggagagcactggaggaaagacacaggttgctggcatcatctctgctgcgattgtgatgatcgccattcttgccctggggaagcttctggaacccttgcagaagtcggtcttggcagctgttgtaattgccaacctgaaagggatgtttatgcagctgtgtgacattcctcgtctgtggagacagaataagattgatgctgttatctgggtgtttacgtgtatagtgtccatcattctggggctggatctcggtttactagctggccttatatttggactgttgactgtggtcctgagagttcagtttccttcttggaatggccttggaagcatccctagcacagatatctacaaaagtaccaagaattacaaaaacattgaagaacctcaaggagtgaagattcttagattttccagtcctattttctatggcaatgtcgatggttttaaaaaatgtatcaagtccacagttggatttgatgccattagagtatataataagaggctgaaagcgctgaggaaaatacagaaactaataaaaagtggacaattaagagcaacaaagaatggcatcataagtgatgctgtttcaacaaataatgcttttgagcctgatgaggatattgaagatctggaggaacttgatatcccaaccaaggaaatagagattcaagtggattggaactctgagcttccagtcaaagtgaacgttcccaaagtgccaatccatagccttgtgcttgactgtggagctatatctttcctggacgttgttggagtgagatcactgcgggtgattgtcaaagaattccaaagaattgatgtgaatgtgtattttgcatcacttcaagattatgtgatagaaaagctggagcaatgcgggttctttgacgacaacattagaaaggacacattctttttgacggtccatgatgctatactctatctacagaaccaagtgaaatctcaagagggtcaaggttccattttagaaacgatcactctcattcaggattgtaaagatacccttgaattaatagaaacagagctgacggaagaagaacttgatgtccaggatgaggctatgcgtacacttgcatcctga
示例性人野生型SLC26A4 cDNA(SEQ ID NO:6)
ctcagccttcccggttcgggaaaggggaagaatgcaggaggggtaggatttctttcctgataggatcggttgggaaagaccgcagcctgtgtgtgtctttcccttcgaccaaggtgtctgttgctccgtaaataaaacgtcccactgccttctgagagcgctataaaggcagcggaagggtagtccgcggggcattccgggcggggcgcgagcagagacaggtcatggcagcgccaggcggcaggtcggagccgccgcagctccccgagtacagctgcagctacatggtgtcgcggccggtctacagcgagctcgctttccagcaacagcacgagcggcgcctgcaggagcgcaagacgctgcgggagagcctggccaagtgctgcagttgttcaagaaagagagcctttggtgtgctaaagactcttgtgcccatcttggagtggctccccaaataccgagtcaaggaatggctgcttagtgacgtcatttcgggagttagtactgggctagtggccacgctgcaagggatggcatatgccctactagctgcagttcctgtcggatatggtctctactctgcttttttccctatcctgacatactttatctttggaacatcaagacatatctcagttggaccttttccagtggtgagtttaatggtgggatctgttgttctgagcatggcccccgacgaacactttctcgtatccagcagcaatggaactgtattaaatactactatgatagacactgcagctagagatacagctagagtcctgattgccagtgccctgactctgctggttggaattatacagttgatatttggtggcttgcagattggattcatagtgaggtacttggcagatcctttggttggtggcttcacaacagctgctgccttccaagtgctggtctcacagctaaagattgtcctcaatgtttcaaccaaaaactacaatggagttctctctattatctatacgctggttgagatttttcaaaatattggtgataccaatcttgctgatttcactgctggattgctcaccattgtcgtctgtatggcagttaaggaattaaatgatcggtttagacacaaaatcccagtccctattcctatagaagtaattgtgacgataattgctactgccatttcatatggagccaacctggaaaaaaattacaatgctggcattgttaaatccatcccaagggggtttttgcctcctgaacttccacctgtgagcttgttctcggagatgctggctgcatcattttccatcgctgtggtggcttatgctattgcagtgtcagtaggaaaagtatatgccaccaagtatgattacaccatcgatgggaaccaggaattcattgcctttgggatcagcaacatcttctcaggattcttctcttgttttgtggccaccactgctctttcccgcacggccgtccaggagagcactggaggaaagacacaggttgctggcatcatctctgctgcgattgtgatgatcgccattcttgccctggggaagcttctggaacccttgcagaagtcggtcttggcagctgttgtaattgccaacctgaaagggatgtttatgcagctgtgtgacattcctcgtctgtggagacagaataagattgatgctgttatctgggtgtttacgtgtatagtgtccatcattctggggctggatctcggtttactagctggccttatatttggactgttgactgtggtcctgagagttcagtttccttcttggaatggccttggaagcatccctagcacagatatctacaaaagtaccaagaattacaaaaacattgaagaacctcaaggagtgaagattcttagattttccagtcctattttctatggcaatgtcgatggttttaaaaaatgtatcaagtccacagttggatttgatgccattagagtatataataagaggctgaaagcgctgaggaaaatacagaaactaataaaaagtggacaattaagagcaacaaagaatggcatcataagtgatgctgtttcaacaaataatgcttttgagcctgatgaggatattgaagatctggaggaacttgatatcccaaccaaggaaatagagattcaagtggattggaactctgagcttccagtcaaagtgaacgttcccaaagtgccaatccatagccttgtgcttgactgtggagctatatctttcctggacgttgttggagtgagatcactgcgggtgattgtcaaagaattccaaagaattgatgtgaatgtgtattttgcatcacttcaagattatgtgatagaaaagctggagcaatgcgggttctttgacgacaacattagaaaggacacattctttttgacggtccatgatgctatactctatctacagaaccaagtgaaatctcaagagggtcaaggttccattttagaaacgatcactctcattcaggattgtaaagatacccttgaattaatagaaacagagctgacggaagaagaacttgatgtccaggatgaggctatgcgtacacttgcatcctgaaagtgggttcgggaggtctctatgagcaaggaatacaagacaaaacttcctcaatgcattgactatttcttcagactcaaaacactcattcttttttctattaagccattgaaagagaagcactaagactgcttctaggctttatttataaaataaacaccttatccctaacatgggcaaaatggctagaattattcagacgatttggcagcgtccagggtaagctggtgttataatacgctgctgatctacatcacagatttgctaataatgttcacgtgggccctggcatatctctgttcagttagagtgagtgctgacccaacagcctctgtggtcaagcgagtcacgaatgattaatcataaagaaaaatcagtttttgactgacctggatatccatgagctgcactgatcaccatgtaaggtcacatttagtaaatgctgaaataaaatgattaatgcatttatcaataaaagcctttgaaaatactttggataataaattggagttttaaaaatgcaaatttgcttagtatctaataatgaagtgttattacatatagccggaattgaggatctctttgatcctggaaatggtttacctaaaagctacagaaccaggccaatatattttgaaatattgatgcagacaaatgaaataataaagagattttcatggtttataaaaatcttttttgatatgataataatcatgatcacaactgagatcaaaaaaatatatgacagattattttgtttaaaaatgcagttttaattatcttagtctatagaaatgatcattgcatggaggcatgtataggtatgatctgtgtaaaatctgacataaaaacagtgctattctgagtgaaaatttttttgatgtgcttacataaccatggtgattaaaatgagtttatattttttctcaaaaattttagcagtgtgtaaagtaagtaatctttaactgaactctgaccacttaaaaaaaaatctaaaaattgaactacctatagtagtctgtgtttaaagtgaatttttaaagacaaagcattctaaatgaactcaatataaaaacattcatttggaatgtacatactgaaaaatacaggtttttttgaccaaaagtttttatatcttttctttttatttatttttttcctaagtgccaacaattttctagatattatatacaacacaggctttgatcttggggacttttcccatatatttcacactggagtgaatgaagttgtacttcatttctagagaaaagttatacccaggtccccaattgagaatgtcttgcttgattgaaaacgacatcatcccttggtatactccagggattggtttcaggacccctgcatttaccaaaatttgtgcacactcaagtcctgcagtcacccctgcctaaagatagaatggcttctctgtttttcttctgaaatacaaccagaaacaatgtgtctatttctgaaagaataggattaatgatcatacaaatgggttaatcctgaattctggttgtaaatctggttacagcataactaggattataatgctgcctcattttcacagcactacttgcttatattgacaacaaatcatctcgctaaagagtgaatgtaggccaggcgcggtggctcatgcctgtaatcccagcactttgggaggccgaggcgggtggatcacgaggtcaggagatcgagaccatcctggctaacatggtaaaaccccgtctctactaaaaatagaaaaaaagaaattagcctagcgtggtggctggcgggcgcctgtagtcccagctatttgggaggctaaggcaggagaatggcgtgaacccgggaggcggagcttgcagtgagccgaggtcgtgccactgcactccagcctgggcgacagagcaagactccgtctcaaaaaaaaaaaaaaaaaaaaaaaaagagtgaatgtaatagtcttgcagaaaatgaatgaatacctttgttcaataaaggaaatatgcactgctcacttttttgaaggaaatgccaaagttacgttttacaacaaggctagagtttgtaaattctgggttcatttgtgatgacataagtcagcaaactgcgggaatactgtctcttctatgtattttgtgaatagtaagcataattttagttttgtattatcaatgaaaatttcacttgaaattaaagctgccttttgttatatttttaacctataggataagattccagtattgtatatgagttttaacaaattaaaaaatcaaatcatgtacatttgaaaatatttgcacacatttaaaaataaatgtaaagttgtcttttaaactactcggatgtgtcctttctgaacaa
人野生型SLC26A4基因组的非限制性实例是SEQ ID NO:7。SEQ ID NO:7中的外显子是：核苷酸位置1-221(外显子1)、核苷酸位置1005-1171(外显子2)、核苷酸位置2262-2801(外显子3)、核苷酸位置11504-11614(外显子4)、核苷酸位置13530-13714(外显子5)、核苷酸位置14311-14475(外显子6)、核苷酸位置22568-22720(外显子7)、核苷酸位置22821-22903(外显子8)、核苷酸位置28419-28566(外显子9)、核苷酸位置29490-29603(外显子10)、核苷酸位置33769-33846(外显子11)、核苷酸位置33987-34082(外显子12)、核苷酸位置35299-35405(外显子13)、核苷酸位置37408-37477(外显子14)、核苷酸位置39449-39541(外显子15)、核苷酸位置40467-40562(外显子16)、核苷酸位置41193-41423(外显子17)、核苷酸位置43697-43751(外显子18)、核苷酸位置49420-49565(外显子19)、核苷酸位置51905-51988(外显子20)和核苷酸位置56348-57175(外显子21)。内含子位于SEQ ID NO:7中的这些外显子中的每一个外显子之间，即，处于核苷酸位置222-1004(内含子1)、核苷酸位置1172-2261(内含子2)、核苷酸位置2802-11503(内含子3)、核苷酸位置11615-13529(内含子4)、核苷酸位置13715-14310(内含子5)、核苷酸位置14476-22567(内含子6)、核苷酸位置22721-22820(内含子7)、核苷酸位置22904-28418(内含子8)、核苷酸位置28567-29489(内含子9)、核苷酸位置29604-33768(内含子10)、核苷酸位置33847-33986(内含子11)、核苷酸位置34083-35298(内含子12)、核苷酸位置35406-37407(内含子13)、核苷酸位置37478-39448(内含子14)、核苷酸位置39542-40466(内含子15)、核苷酸位置40563-41192(内含子16)、核苷酸位置41424-43696(内含子17)、核苷酸位置43752-49419(内含子18)、核苷酸位置49566-51904(内含子19)和核苷酸位置51989-56347(内含子20)。
人野生型SLC26A4基因序列(SEQ ID NO:7)(NCBI参考序列：NG_008489.1)
1 ctcagccttc ccggttcggg aaaggggaag aatgcaggag gggtaggatt tctttcctga
61 taggatcggt tgggaaagac cgcagcctgt gtgtgtcttt cccttcgacc aaggtgtctg
121 ttgctccgta aataaaacgt cccactgcct tctgagagcg ctataaaggc agcggaaggg
181 tagtccgcgg ggcattccgg gcggggcgcg agcagagaca ggtgagttcg ccctgaagat
241 gcccacaccg cccggcccgg gctccactcc cggggaggcc tcgagggttg cggatgggac
301 tcttaagtgg tcacggatca ggtgggcagg gggcagtaca gctttctttc tgagacgccg
361 agagcgaaca ggctgctcgg aaaacaggac gaggggagag acttgctcaa taagctgaaa
421 gttctgcccc cgagagggct gcgacagctg ctggaatgtg cctgcagcgt ccgcctcttg
481 gggacccgcg gagcgcgccc tgacggttcc acgcctggcc cgggggtctg cacctctcct
541 ccagtgcgca cctggagctg cgtcccgggt caggtgcggg gagggaggga atctcagtgt
601 ccccttccag ccttgcaagc gcctttggcc cctgccccag cccctcggtt tgggggagat
661 ttcagaacgc ggacagcgcc ctggctgcgg gccatagggg actgggtgga actcgggaag
721 cccccagagc aggggcttac tcgcttcaag tttggggaac cccgggcagc gggtgcaggc
781 cacgagaccc gaaggttctc aggtgccccc ctgcaggctg gccgtgcgcg ccgtggggcg
841 cttgtcgcga gcgccgaggg ctgcaggacg cggaccagac tcgcggtgca ggggggcctg
901 gctgcagcta acaggtgatc ccgttctttc tgttcctcgc tcttcccctc cgatcgtcct
961 cgcttaccgc gtgtcctccc tcctcgctgt cctctggctc gcaggtcatg gcagcgccag
1021 gcggcaggtc ggagccgccg cagctccccg agtacagctg cagctacatggtgtcgcggc
1081 cggtctacag cgagctcgct ttccagcaac agcacgagcg gcgcctgcaggagcgcaaga
1141 cgctgcggga gagcctggcc aagtgctgca ggtagcggcc gcgcgggcctgcgtagagag
1201 aagcggagcg gggcgtccac gccttgggga gggaagggcg tccccagcgggcgagagtgg
1261 ggtgcgggcg gcggagcccc tgggcgccag ctgcttctcc cagaggcccgactttcggtc
1321 tccggtcctc cacgccgccc ttctggtggg agggtggctc catcagtctcgggcccgaaa
1381 tgaacttacc tgggaaactc gcctttgggg agagtgggtt ctaggagccccgtctctctt
1441 tttcctctct gaaggaaact tggagtgcct cttggggtac agtgggtccctgttgccttc
1501 ttgggagctt gtttaaatga aatgaatagg gaaacccagc tcttgaccaggaggagtcct
1561 tgaaacactc aagctaagta ggcgggctac cattcagtta gagaccaggatgcaagctag
1621 aacccagggg agcgcggggt gtgccaagta cttcatcagc aggctgtgggacccctgggg
1681 aaagccaccc tcagtctcta aacccaaaca tgccgtaact agatgtcacaaacataaaga
1741 aattagagtt tctaaaacct ttcattatag aacatttcaa atatatgcataagtagacgt
1801 agtagtataa tgaactcccc acccccaccg tttttaaccc atcactcggcctcaactgtg
1861 atcaaatcca agttactctt gtttcttgta tctacaccta cttgctccctccagtattat
1921 ttttaagcaa atctcatata gcatactgtc tttatgtatt ttactgcatatctttaaaga
1981年ctcttaaaaa atataaccac atttcatgat cacaccttaa tatctaaaaataacctccta
2041 atatcaaaaa ttgagtcatt attaaaatgt ccaatcgtcc cataaatgccttaattaaaa
2101 aacaatttat tcaaatcagg agttatacca cctacttttg atatttttctttcatctgta
2161 ggtcactgaa tttaaaaact accaagtagc aaggtataag gtatacattcctcatgctaa
2221 gatttttgta aaaactagct ccaggcttgt attgccaaaa tatactcagtgtgtttatct
2281 tctttaaaga aaataataat aataaggcgc ctggattagg agtctgaaaagtaatctcca
2341 tttagagact ccacatccat cagtctctgg ctggaccaga aaataggtttttgtgtagga
2401 atattttttc agaggattaa aaatgtgagc gaggggtggg acacttaatcctgtgttctc
2461 tagaagagtg catttaaaag gatagataca gttcttggca aaagcatggtaagcacttca
2521 gggttattat tttccaggaa atacttatcc tttttccaaa tagttataaacatcagcaga
2581 atccagttca taactttgtg atttgcaaat tggttgtgac tgagattggattgaaaaccc
2641 agttttcttg ctttttgaca gttgttcaag aaagagagcc tttggtgtgctaaagactct
2701 tgtgcccatc ttggagtggc tccccaaata ccgagtcaag gaatggctgcttagtgacgt
2761 catttcggga gttagtactg ggctagtggc cacgctgcaa ggtaagatgttggcagattg
2821 agagttctgg tctccagcag gagtttaaca cttctcccca gctaccataggtctgtgaca
2881 gatggttgct tacccttcaa ggcctgtatc tttcctgtag agccccttagtggagagagt
2941 cacctctctt ctccccttcc ttagagttct cttcctggga aactgctgccccactaggtg
3001 cagaggtcca atttagaggc atatactagg cagtggcttc tcaatttttttaaattttat
3061 tttatttgag acgggggctc gctctgtcac ctaggctgga gtgcagtggcgcaatcctgg
3121 ctcactgcaa gctccgtctc ccgggttcac gccattctcc cgcctcagcctccccagtag
3181 ctgggactac aggcgcccgc cactacgccc ggctaatttt ttgtatttttagtagagacg
3241 gggtttcacc gggttagcca ggatggtatc gacctcctga cctcgtgatccgcctgcctt
3301 ggcctcccaa aatgctggga ttacaggcgt gagccactgc acccagccagcttctctatt
3361 ttcattgacc acaattcaat aagaaatgtg taaagagttt caagtcaagatttaaaaaaa
3421 aaaaagaaat gtgttacatc ctgatatata catatatatc taaagttcctgtgaaatatt
3481 tattataaca atgtgctaat ctttcacttt gttctattat gcttaggttttttaaatgat
3541 gattgcagca cattaaatta ttttatatcc acacgtggat cttttttgttggtttgtttt
3601 gctttgcttt ttagagatac agtcttgctc tgtcacccag gctggtgtgcagtggcacga
3661 tcttggctca atgcaacctc tctgcctctc gggttcaagt gattcttgtgcctcagcctt
3721 ctgagtagct ggggctacag gcatgtgcca ccatgtccag ctaattactgtatttttagt
3781 agagatgggg tttcgccatg ttggccaggg tggtctggaa ctcctaacctcaagtgatcc
3841 gccctccttg gtatcccaaa gtactgtgat tacaggcatg agccaccatgcccagcctcc
3901 cacacgtgga tcttgaggtg tagtttgaaa ctggcttaag gaaaagtgaagggagcttcc
3961 tagcctggac tccacatgaa tgttttgcct gcccctcatc cctttttaaaaaaattcatc
4021 ctcttatttt aatgtgtggg aaaatgtgcc aacataggtg gttatttgttcttttataaa
4081 ctgagttcat accataatat tcccataagc atcttagaaa tctgttgtatagttggtgcc
4141 tagcagcatg gcattctcct ctgtccccta tccccaccat ctcgtttctgccccaccccc
4201 aacaccctga ccaatttccc aaagaccctg aatcatgaaa acagaaatatcgttatttat
4261 tataatttgt gaaacaccta atatgttcca ggcactaggt atgctgacacgaataagatg
4321 catcctctgc ttccaaggaa ctcatagtcc aatggagaaa gagaaaacaattcaatgtga
4381 taagggctgt ggcaggggag tgcaaattac ttgctaaggg agtgcaaatgaggttcactc
4441 aaagcggtct taggggatct tgaatagctt cctggaagtt gaatgtcaaagctgagtttc
4501 cctgatggct aagtctgagt ttgccaagtg atgggaagta gggtggggtggggatggctt
4561 gaaaatagac tatttcagaa gctagtaatg aatgttgagc aatattgtgagctaaaattt
4621 ggctatggag ctttcaagat tgctcagatc aggccaggta gatgcccgaagagaaggagg
4681 atggcctatg aacccagggt ggagcctcag cctgatcaag catgttcttaatcacaaagg
4741 tggacgggag agagactagg atgggctgtg tggttcctaa gttaaacaatgccaagtatt
4801 ctacactgtg ctctaagggc tgtgacatgg tgacaccctg tgactcctgggggacaggaa
4861 ccatgcctca ttcatgtttg ttcagcaggt gcctagcaca gagacaggcacataatagat
4921 ggtatattta gtgaaaaaga ttgaattgca ttcctgataa tgaatcttctttatatataa
4981 aaaatggtgg ttcatgctcc atgtctcccc agttttcata gacaagtatcttataagaat
5041 tcattttgtt tataagcatg agacactatg ctaagtaaga atgttgccagctatctcatt
5101 taatcctcat aacaatcctg ctaggtaggt ctattattat ttcattttcagtaggtgaaa
5161 aaatctatta aatcttgccc agggtcacgt ggctggtaag tggtacagctgggattttaa
5221 tccggtgtct attgtgtagt tccttacttt atgggtaaga tgcttttctagaaacattat
5281 ctctataaag ttttctgtgt aaggtgaatt tctgggaggt taatctggctcagttacaca
5341 tccatttatc attcattcac ttaataaata tttataaact aattctgtagaccaggtatc
5401 cagccatgtg cactcagtgg ttcattaaca ggcacaggtg ctgacttcatggagctttgt
5461 aaaattattt tgaggggtag ggatgggaat taaataagta gataaatagaaaaataatta
5521 tagattgcaa tatctattgt ggtggattaa atatactgca atagggattaatttgaaagg
5581 tggatcttta tttttatatt tttttgagac agggtcttgc tctgttgcgcaggctggagt
5641 gcagtggtga gatcacagct caccacagcc ttggcctcct gggcccaggtgatcctccca
5701 tctcagcctc gccagtagct ggaactacag gcatgtgcca ccatgcttggctaatttttg
5761 tattttttgt agagacaagg tttcaccatg ttgcccaggc tggtctggaactcctaggct
5821 caagttatct gcctgcctcg gcctcccaaa gtgctgggat tagaggtgtgagccattgtg
5881 cccagccagg aagggaggtc tattttagat ataatggtca aggaagaacttactgagaag
5941 gtgaaattta gtaaaagaca agagaatgag aaggagacag ccatgtgataagcagaaaaa
6001 aagagtgtac caggtaaagg tgcaaaggcc ctgaggccag aaaacttagcattttccagg
6061 gaggaagagg aagaattgta gtgtggatga gtgcagtggg ggagggtgagtaaaccatga
6121 aataaactga ggcaggactg ggattaggat gaggtaaggg aggcactcactctcaggatg
6181 cctctttaaa tattgtaccc taggaaactc atttgcctca ccctattcctggccctgtgg
6241 ggatattgct gtgaattaaa gggagaatgg gtgtgtcagc ttgaaccagatgatgcaggc
6301 tatgaagaga gctgcaagat aggaatatat tgtgcagcaa gaatcactgacacataatga
6361 tgagtgtgga tgaaaatcac tgatgcctcc aaggttgttg gcttgagcaaccggatagat
6421 cattacatca tttatctaaa tggcaaagac aggctgagga gcaggtttgggataggaaat
6481 caagtttcct tttggatatg ctaagtttga gacacagggt gagacatctaagtggagatg
6541 ccacctagag aagtgggagc tactgcaagt gtgaaggtta gaggagaggtctaggctaga
6601 cataaaaatc aggaaagcat tgctgaagag gtgatattta caagagtgggaatgcctgtg
6661 attacctagg aagaaagggc aggtgtagaa gaaaagagag ccagagtacttagaagttag
6721 gaaggcaagg agaggggcag ccaagaacct gagaaagcct ggcgcaggaagttgaagaca
6781 aagaacaacc aaaggaatgt gggatcagaa gccaagagag aaggtttaaaaaaaaaaaaa
6841 aaaaaaaaaa agcatagagg ggctgagagt gttgaatttg cctgaggggtggggtatgat
6901 gaaggattac agactgcttt taagaagttt tgccatgaat cagagggagataagagatga
6961 agacagagtg aagggagaat ttgtttttct taatatggga gatactagaacgtatttgtg
7021 aaccgatagg aatgacctag tagaaagaaa gagatctgtg gtgcaagaagtacaagagaa
7081 ataactagaa gcaaagtagt aaaaaggggc aaacgtggag gggtttgagaatggaactag
7141 gagaactact ccttaaaggc aggagggata tttcttccat tttcaaaggaagatagccca
7201 aatggtgcag atgcagacgg gtttgaaatt ttgatgaaaa gtaacttgggagcatctcat
7261 gcattctgtg ttttcgatta aatgcagaat atgtccctta actttgagtctggtggagaa
7321 gggtttgggc agattgaggt aagtagggga ggtttgaata gttgtctcaaggagaggaaa
7381 ggcacacccc ctgaggaaat gtaactgggt ccccaggcag tgttgagtgcccatctagca
7441 cttgtggtca cacattttac atgaaattgg ttagcccaga tgtagatgccttcagtccag
7501 tttatctagc tgctcaaagg ctctcatgga taaggtagat gtttgaggtcagccaaattg
7561 gggttttgcc agacaagaaa aggaaggaaa gagagagtga aaaaagggagttaagaatat
7621 ttgcaaaatt ccatggaatc tgtgtgggca agggtggaag tgaagacaggaaggtgtgga
7681 ggatagagag aaagtggatc ggttaattaa ttagaagcct cgtgagcacaaataaatgtt
7741 gcaataagga ttctgcagta gatgagctgg aaggtttgga ggctgtagctggagagaggc
7801 tcaaaattca gattttggag gtggtggtgt ggtttccagt gatgacaatgtccatgccac
7861 aaccactggc tgagcagctg agtagtagaa caactccgag aagaccagctcaggttactg
7921 ggaagccagg aagttgctaa ggatgatggg atctttgtga tttttgttattaaaacaaat
7981 tcccatcaga cagcaaaaga tcgatgcaac ccttgtagtg ctatttttattcacaacttt
8041 aaggagtctg ctgtctgctt tctccttttg acttttatgt atttgtttgtttaaacaaca
8101 gaaatttatt tctgcaacat gaaggtgcct gtagattcag tttctggtgacagcccgtca
8161 ccttgctgcg tcctcacatg gtggaaggct ttacctttag aagaaatttaaatttaatat
8221 aaatttcaac tgtttattag cacctgcttt gccagtattt gtcaccatgctataaatcat
8281 gactaccaac agagaaattc tatcatttaa atcaatggct cagatttcttctaatttttt
8341 ttcttttttg agactctttc tcacacaggc tggagtgtag tggtatgaccttggctcact
8401 gcaaccactg cctcctgggt tcaaactatc cttgtgcctc agcctcctcagtagctgaaa
8461 ttacaggcat gtaccaacac ccccagctaa tttgtgtatt tttagtagagacgagatttc
8521 accatgttgg ccgggctggt cttgaactcc tggcctcagt gatcttcccacctcagcctc
8581 ccgaaatgct aggattacaa tcatgagcca tcacacctag ccccagatttctttacaaat
8641 tgtgtaattt taaaactgtt gtaccaagtt tctttataat aaagatgattccagtatatt
8701 tgagtagtag tggtccctaa atgggacact ctgtatgaaa actgaaaagttccccttttc
8761 caggcatatt aagaactgca gagcccagtt tggggaaatg gaagtttgagaaggacttga
8821 aaaatgtcca tatgaaatag acaagttgtg ctttcatccc ctgctccttcttttcttatc
8881 ttccttctgt ggagtcacct tcctatttta ttccatgctg ttgggactactgactattgc
8941 aattcctgtt tgtaatttac atattaaaac aattgtacta atagatatatttttctagaa
9001 tacaaactcc actagggcag agactttgtt ttaacagtgc ctgacacatggtaggtgcat
9061 aatcaactgt tgttgaatga atgaatgctt attgtagaaa actagaaaatacatataagg
9121 aacatgaaaa aatacctcca ctacaaacta gaagtctcct ctgatcctaccatacagata
9181 acccattgat atttcagtaa atatcttact aggcacataa atacttatctatataaaagt
9241 ataatgaaat gtctggaaat aataagcacc aaattcagga taattgttgccttctgaggg
9301 tagagggagg aaagaggatg tgattgagga agagtatact gagagtttccgctgcattgg
9361 cagtaattta tttcttaagc tagatgatgg atacatgaaa gtttattatattattcattg
9421 tgtattgtgt ttcttgtata tgtaaattac ttcatatttt attcaaaatacctccagatt
9481 tttttttttt tttgagatgg agtcttgctc tgttgcccag gctggaatgcagtggcgcaa
9541 tctcggctca ctgaaacctc cgcctcctgg gttcaagcag ttctctgcctcagcctcctg
9601 agtagctggg attacaggtg cctaccccca tgcctggcta atttttgtatttttagtaga
9661 gacggggttt caccatcttg gccagggtgg tcttgagctc ctgacctcctgatccaccca
9721 cttcggcctc ccaaagtgct gggattacag gtgtgactca ccgcgcccggtccctccggc
9781 tttttttaat gcgtacactc ccacaggctg gagtgggagt gtattttttacaaaagagga
9841 agcatacata cctatcagtt ttgaatcttg attttactca cttttttccctcttacttca
9901 catctctcca cgttactgaa tgtacttctg agcatcacat caatttcatttcatagaatt
9961 acgaagtatg aagcataact tagttaacca cttccctgct tggggacattcatctgataa
10021 gtaatattga gtgtgtgggg gccagcatat tcaggctgtt gccatttttaataaactact
10081 ataaatgtaa ttccttatta atgactcaag agtgaaaagg cttgattttctctcattgtg
10141 agtgagtgaa gggtgaggag gtaaaacgga gtaagatatg ctggctacctaagtatttaa
10201 ccaaggaaaa gaatgtcatt atcctcttct aaccctcatg taaactagaatgttgatttc
10261 tctatagcca ggcattaatg ggtctggggg ctgctgccat tgcctagtggaggagttggt
10321 caacttcatc agggtagagt tgtcttgtct gctgctgagt ataattatcatattttttct
10381 ttgggtctaa cttttcttcc ccaccaaaaa aggagaaagg gcagtgtaacaatgactgtg
10441 tccctcagaa cgcagagaaa tattgagctc agacacaact gcctctgtgcaaaactggtc
10501 tgagcctttg gagtgaattg accaaaactt ttttttttct tttttagacataaggtcttg
10561 ctctgttgcc caggctggag tgcagtggca cgatcatagc ttgctgtaacctcaaactcc
10621 tgggctcaaa caatcctcct gcctcagcct ccttaataac taggactacaggcgtgaacc
10681 aatatgctgg gctcattcat tttattgtag agatggagtc ttgctatgttttccaggctg
10741 gtctcaaact cctgggctca actgatactc ctgcctatgg cttcccaaagcactgggatt
10801 ataggtgtag gacaccaggc ctgaccaagt ttttaatcaa catttgacttgattgttttt
10861 tcccactgat ctgattggtg gaagactgaa ttactgatca actgagtccattcatttgag
10921 caggtgatgt ttgtagatgc aatcattgtt ccaggtgatt tggatcctgttctgcatcct
10981 agcatagcca gtctgtatgc aagataagga gaccaactca ggacaggctgatctgttgaa
11041 actgtaaatt gagagtatct gtgtaaaggc ccttctttct gcagtagaaagacagatgct
11101 cctctacttc tcatgagtta catcctaata acccattgca agttgaacatattttaagtc
11161 aaaaatgcac ttaatacacc taacctatgg aacatcatcg cttaggctatcctacctgaa
11221 atgtgctcag aacacttaca ataacctaca gttgggcaaa ataatctaacgcaagcctat
11281 tttataataa agtattgaat atctcatgta gtttactgaa taatgtactgaaagtgaaaa
11341 acagaatggt tgtatggtta cttaaagtat ggtttctact gaatgcatattgcttttgca
11401 tcatcataaa ggcaaagtca taagtggaac cattgtaagt tgaggactttctgcatactg
11461 taactttggt ttgtgaatgt aatcactttg catgtgcttt cagggatggcatatgcccta
11521 ctagctgcag ttcctgtcgg atatggtctc tactctgctt ttttccctatcctgacatac
11581 tttatctttg gaacatcaag acatatctca gttggtaatt ataagtatattttacaatta
11641 tatttgctca tgtttaaagt gttttggcta tattaagtgc attatacctctattaggttg
11701 gtgcaaaagt aattgcggtt ttcacaatta tacttttaat tgtgaaaaccgcaattactt
11761 ttgcaccaac ctaatatatc tgtgttaatg ttgtcaggga aatgggatttcagtgttttg
11821 cctgcttttt ctattcactg atgttaggta acttttttaa tgaagtggaaaaataaaaaa
11881 actgaaaatg acagcctact ttaacatttt agcatgtttt gctttttaaaaacgtgatca
11941 atttgactcc atttttggag tcataatgac agggaaaaaa tgacacaaggtctttgaacc
12001 taccatttta ctggattaac ttagaaatta ctaagtatgt tcatcaaatacatgttcatg
12061 atttaattaa agagcatact tattttaaat cactaatatt agaagactggcaaaatctta
12121 ccaaaacaat ttagaagcta agcttggctt tctttcttgg tatggcttataataagtttt
12181 cctgctattc ctaaaatttg aattctcgtt tgttagaatg tcctagtaaatgagtgtttt
12241 aatgctattt tgtgactttg acatttatac tagagaaaat tttgctcctacatccatctg
12301 ctggctagac atgtctacct cgatgatcct cttgaaataa atgcaaccatctactttatc
12361 cccaacccat gtttttgtcc ttagttgtat ttccttagaa ggagatcagaaagaggtttt
12421 gattgaaaga acttccacac cttggagaat caatcagtgt tgagtgcttgactagatgag
12481 gaacatggaa gctggttttt ctctttggta ttctatacat tgagatattccaggtgactg
12541 gggttgggtt ttgagacctc aaaaccataa agccttccat gatgagagggtagaatcatc
12601 atcatcgtca tggataaaaa taacagtagt gaacggagca attgctgaaaaaaaaatatt
12661 ttttaaaata taaaatctta cagattgaca tttgatatga aaaaatgttttgtcttacaa
12721 aaagagaaag aaacttcata ctccctttgc tgttttttta atcctaacttcgaccctgtg
12781 atattgatca aggtactcag atccacagag atcaggacat tggacactctaggaaattaa
12841 tgagattata tgaaataaaa gttgagcgga acaagtaaac actcaatgtatgtgctacct
12901 ttgccagaaa acctttcctg acaactctca tccctgtccc caccacccatacacatgagg
12961 atcacacaca gacaggttag acgacctttt gatatactca cgaagcatcctgaatgttgt
13021 attctaataa ctacctacgt gtctctctcg cctatttcta ggtcatgaatgcctcgagat
13081 atctgcgttt ttagcttctt tttgttgttg ttgagacaga atctggctctgtcacctagg
13141 ctggagtgcg gtggcgtgat ctcagctcac tgcagcctcc acctccccagctcaagcaat
13201 ccccccacct cagcctcccg agtagctggg accataggca cgcaccaccacacccagcta
13261 atttttgtct tattttggta gagatggggt tttactatgt tgcttaggctggtctggaac
13321 tcctgggctc aagcgatctt cccacctcag tctcccaaag tgctgcggttacagatgtga
13381 gccactgggt ccggctcagc ttctttcgtg aacaaacaat attttcctagtcacagctaa
13441 atcttttata cattttttaa accctatgca gacacattga acatttgtgattaataactg
13501 attaattgtt agagactttt tttccccagg accttttcca gtggtgagtttaatggtggg
13561 atctgttgtt ctgagcatgg cccccgacga acactttctc gtatccagcagcaatggaac
13621 tgtattaaat actactatga tagacactgc agctagagat acagctagagtcctgattgc
13681 cagtgccctg actctgctgg ttggaattat acaggtaatg aacttacaagtaaaatatag
13741 atggatgtaa tttttatttg aaattaactt taaagcatat agacttaaagattctactaa
13801 aaacaaaaca aagtaatttc ctggaaccca aaattatttt ctaaattacgttgttttagg
13861 tcaggtgcta aaatagtaag caagacccca cttattaagg ctcacttatcatcaaagtca
13921 gagacagaaa aaagcacaga agaacatgtg tgattcaatt gaggatgagagaagggaaat
13981 atacgggaat ccataaagga gaaaaagtgt tctggtgagc ggagacacaggaccgaaagc
14041 cacataaata agctctgggt ttttgctttt ctaagtacat gtatagaaatacttcaaggt
14101 ttttattaca cttagttttc aaattttaga gtggtggagg aaggggagtgatagggtatt
14161 aagaaattca tatttttttc taccagtatt tttgtgctat aggcaggctactagtgtttt
14221 cattggtatt aagcttgatg taatatttcc agagagtagg tttctatctcaggcaaacat
14281 ttaatttttc tttccttttc cttatcgtag ttgatatttg gtggcttgcagattggattc
14341 atagtgaggt acttggcaga tcctttggtt ggtggcttca caacagctgctgccttccaa
14401 gtgctggtct cacagctaaa gattgtcctc aatgtttcaa ccaaaaactacaatggagtt
14461 ctctctatta tctatgtaag tgttgcttct tgctccaggg atgggtcactgttcattcca
14521 gaaacaattg tattcattct ctgagtctgg gccaggcgtg gtggctcacacctgtaatcc
14581 cagcactttg gaaggccgag gtgggcagat tgcttgagcc caggagtttgagacgtgaga
14641 cctcatctct taaaaaaaaa aaaaaaaaaa aagaaagaaa gaaaagaaaagaaaaagaaa
14701 gaaaaaatcc aaaaatccga aaatttgctg ggtgtggtgg tgcacacttgtagtctcagc
14761 tacttgggag gctgaggtgg gaagatctcc tgagccctgg aggttgaggctgcagtgagc
14821 tgtgatcgcc ccactgcact ccaccctggg tgacagagca agaacctgtttcaagcaaaa
14881 acaaaatcaa aacaaaacaa aacttgagtc tgggagcacc cacatttctttctttctttc
14941 tttttttttt tttttttgag acagagtctt actctgtcac ccaggctggagtgcagtggc
15001 atgatattgg ctcaccacaa cctccacctc ccgggttcaa gcgattctcctgcctcagcc
15061 tcctgagtag ctgggattac aggcgcccgc caccacaccc agctaatttttgtatattta
15121 gtagagacag ggtttcacca tttgggccag gctggtcttg aactcctgaccttgtgatcc
15181 acccacatcg gcctcccaaa gtgctgggat tacaggcgtg agccaccgcgcccggcctgg
15241 gagcacccac atttctctat gcatactttg ggagccattg aaaacatttggttgcttctg
15301 tcagaaatac tattgtactt aaaaacatta atgaaaacaa agtggtctaatgaagtaaag
15361 gctgctctgg aatgtaacag acttgatttc tagcctcagc tttgtctctaacaggtaagt
15421 gaccctggat acatcatgta gggtgctaat tgaaagctca gttttagaactggatggacc
15481 ttgattcata ttctggctct actgtctact agccatgtga gccaatcaccatgcctcagt
15541 ttccttctct gcaaaattgg gttagtaata gtatatgcct cattggattgttaaataaga
15601 atagataagc acttggccca ggggctggta cataacaagt actctaaataaaggagttat
15661 tttgaaatga ttatttcaag ccatcttttc ttttttattg gtgaaatgaaatgattggag
15721 atgtatctct aaaagctttt tctaaccata agagtccgta aaatgcataatgtaaatgtc
15781 tcaacaatta taaatgaaaa ggaacattag attcagagat gattcaccatgcaaaagaaa
15841 tgcaaaagca ggatgtagat cacactaatt agatttgaaa aaggttttggatctaaaaat
15901 gtgttctaca taaagcatgt tattgatgct tgaaaaatgg tgataatagtaacatgatgt
15961 catcctagct tggggggaat gataccatac aaaaataacg tgtcaacattaagaatggag
16021 tttgagtctt taaagaccca cctattagct tctaaaacaa tgtaaggccatgtacacata
16081 tctaagaatt ggtgagtatg tcaataattg ctcaatttta taacggtgccataatcccat
16141 actattacac tccatccatt caacaaatat taccaagtgc ttactacaggccaggtacta
16201 tgctaagcag tgagaataga cagaggaggc agaataacat agtgaataagatcatgaggc
16261 caggtgtggt ggctcatgcc tgtaatccca gcagtttggg agactgacacaggtggatca
16321 cttgatccca tgagttcaag atcagcttgg gcaacatgac aaaaccttgtccctactaat
16381 aatacaaaaa taattagaca tgcattgtgg cacgcacctg tagtcccagctacttgggag
16441 gctgaggtga gaggatcacc tgagctcagg aagttgaggc tgcagtgagccgagatcatg
16501 ccactgcctt ccagcctggg tgatgggagt gagaccctgt ctcaaacaacaataacagca
16561 acaacaaaca aaaaaccaaa aacaaacaaa aaagatcatg gactttgaacttcaacagac
16621 ttgagttggc atcttggttc tccacccact acccatgatg tttatactcaacttccctaa
16681 gcctcagtgt cctcaattgt aaaatgggag tagtaatagt agctacctcttagagcagtg
16741 aggattgaaa aagaaaatac gtgtaaggca cttagcacaa tatctgtcacatagtaagaa
16801 ttgagtttat tattattatt atcacagatg aatagacctc atgaagctcgccgttcattt
16861 cctcgggacc cagcctatta ggaaacatta gcaaaagttt ttgattcagcattatatggg
16921 tcattcttga tatgtttttt cctgtcaaat cctcagtttt ctattaaaaaagaatttttt
16981 tttttttttg agacagggtc ttgccccatt gcctgggctg gagtacagtagcacagtcat
17041 agctcactgc gacctccatc tccctgtgtc aagcgattct tccccctcagcctcatgagt
17101 agctggaact acaggtgtgc accaccacac ctggctaatt ttctttttctttgttgaatt
17161 ttagtagagg caatgtcttg ctatgttgcc caggttagtc tcgaactcctgagttcaagt
17221 gatcctctca ctttggcctc ccaaagttct gggattaaag gagtgagccaccatgtccag
17281 cccatatttt aaaattaaaa ttaaaatttt aagattttat tttggtagagacaggggttt
17341 tgcaatgtcg cccaggctgg tcttgaaccc ctggcctcaa gcagtcatcttactgcatgc
17401 ctcctaatgt gttgggatta taggtgtggg ccactgcacc tggccaatccttagttcttt
17461 ttgagacctc tgactgcctt attttgacag gctctgtaac ttttgcagctcctggcacat
17521 cttgctttta cttactttta cattttctcc atcaaatgtt cactcatttattccttcatt
17581 ctcattcatt cagtttatct actcaataaa cacatattga atacttaccatgtgccaggc
17641 actgttcact ccctatacaa acccagtgac tcattaacct accaagacatctcttactga
17701 gtattctcac ctcactgggc aaacattgct aggccttcat ctacacagatcgcaggaggt
17761 ccaaactaat tgttgacctg ggtccatggc catttcagga cccctgcagaacaggagaaa
17821 tagttcttct ggtctcatag gattatgttt aagaagaaac tttctgcaaatgatttcact
17881 ttgacaggga caaaagtgag caggaaacac tagaccaagg tcaaaaatagtttttaaacc
17941 aagtgcagtc attatgtaac ttacttcctg ttgaatattt ttcttgaaatctcagtttag
18001 catacagcat agaattttgc aagaaactcc tcacaggcca cccaagttggaaaaggtatt
18061 tcagtcatcc ctatatggtg gtgaatataa gtttgctctt ctgaaaaaaaaaaaaaatca
18121 gcaggtctga aaacgattgc atagggttaa atgagccgct tagtctctgaacagagaatt
18181 ttgcttatga cattaccatt gcaattatac atgaaagaat ccttcaataaatgcagagta
18241 gtagaggatt ctcccagaaa agactgtaag attgttgtaa aatactttacctggagtgtt
18301 aacttatctt tgttctaagg ttgcactttg gtttgtcctg ccctctcccccaaaaaggtg
18361 ctgacaacta gaagtaacaa atgcaaagaa ataggggaga aaatattagaagaaaaagaa
18421 atcagttaat ttacaaatgt cagagatact ggatgtagga ggcagaagggagaatgacag
18481 ggtattggca gcaatttaga attagtcaat acccttgatg ctaccatgtagctactcagt
18541 tatctaagta aatcccagtc cacttagggg ttgatttccc accactcaatttgaatggtt
18601 tgtctcagta gacaagggtg agagctttga aagccaccac taagcttgattagatttgtt
18661 actttgtacc tatttcagta tgtaaaattt atacattgta ttaaagtaacactttaagga
18721 ttgatctata catgtataca caaaagatat ggaaggaaat gcctgacagcaaaaggtggt
18781 cgtgaagcat ttgtgatatt cgtagagata aaataaacaa aaataaattcagttccaata
18841 gtaaactgat caattttctc atacacatta ttgggcataa ttttttcttacggtttcata
18901 aacacaggta atcctgggca agaacaaaga aattatctaa atgaaattgtcctaaaattt
18961 tccaaacaca gcaggaaata taataaaata ttatctatta ccaaaaagttcattatcata
19021 atttgaatta tttggaatac taagctaaaa tacagaatta tatgtgtatccatactatta
19081 acatacttta tggtatttta acagtaaact aaattagaag tactgttcagtgtttttgta
19141 gagtctaatt tctatgtcgt taaatataat cttatattat tatataatataatcttatat
19201 tattatataa tcttatatta ttatattata taatcttata ttatataatcttatcttata
19261 taatcttata ttatatgctc ttatataata taatcttatt atataatcttatcttatata
19321 atataatctt attatataat ataatcttat tatataatat aatcttatcttattatataa
19381 tataatctta ttatataata taatcttatc ttattatata atataatcttattatataat
19441 atattcttat cttattatat aatcttatct tattatataa tataatcttatcttattata
19501 taatataatc ttatcttatt atataatata atcttatctt attatataatataatcttat
19561 cttattatat aatataatct tataatataa tcttaactta ttatataatataatcttatt
19621 atataatctt atcttattat ataatataat cttatcttat tatataatataatcttatat
19681 tattatataa tcttatctta ttatataatg ttatattatt atataatcttatcttattat
19741 ataatgttat attattatat aatcttatct tattatataa tcttatattattatataagt
19801 ataatctttt attatattat tacataatat ataagtataa tcttatattattatataata
19861 ttattattat acaataataa tgtaaactga ctattgcagt ttacatggtgagttttattt
19921 ctgcacagat taaactttct atcatagagc tcttcttaaa agattctgaatgactactca
19981 atatgtaggc aacttattta catactcaga taccttgcat gatgcaattctgtaatataa
20041 actgattttg gtttttgaac ctcgtgttac atttctaatc caccagacatactttttatt
20101 caaaggtcta attgattctc atggattaaa ctggaatcct gtagtgattatttttgtaag
20161 gtaaaaatgt ttgtgtgatt gggataatga ttccaaatgt tttgtttttcaagttttaat
20221 ttttgcatct tgagttgaaa agtacacctt taatgaatag acaattcatcaaaatgttat
20281 acctagctcc tgaattaatt agggtcattc atcagaaaac tgattatgtaaaggaccaaa
20341 cagcaatgat aaccttcaag cctctgggat aggtagggct gtttgctcctgtgctaaatg
20401 ccctaagttc ttgttatcgt gtctgctggt ggtagttatc ccattttctttttcactctg
20461 ctgtccctgg catcatcttg tttctgtcag tgtaaatgcc tttagcaattttcagtgact
20521 ctgaaaacca gacaaagtga atttgttagt actggatttc aagaaagagcaaaagtaccc
20581 tctgagtgaa agttcaagag tcttcctaca agttaaatgc ctgaactctagtccaagtgt
20641 ttggtgggag gtattttgca tgcataatag cttctccccc atttccttactcttcttgaa
20701 tgtgttccag agagctgagg ttgctggcaa agtgactcct agattacttaaggttcatta
20761 agtacttaaa gttcattaag ctcatacata attgtcacca gattatcattataattattt
20821 taaaagtagt ttatctgtga aaataagtaa aatacatttt ataaatgttataaactataa
20881 gatgctccat tattttatct tcctataaaa tatgtctata aaaaagctcatttaaagaaa
20941 agttaccttc actgtgagat tgtctcaaag aaatgtctca aagataccttcttaaatcct
21001 gccttctaca ggactgaagt taatataaca aagatattag tgttcttccttgggattctt
21061 ccttgctaat ttccttgaaa acacccttga ttcccagaag tctcctatttacaaaacaaa
21121 actagttttt cttgaattga ttcatctgtc tacttaaaga ttttttttggccagttgtgg
21181 tagctcatgc ctgtaacccc aacactttga gaggttgggc aggaggatttcttgaggcca
21241 ggagttcaag accagtctgg gcaacaaagt gagacaccat cccctgcccccacctcctcc
21301 cgccccaatc tctacaaaaa ataaaatagc ctatttattg tactctctacaataaataaa
21361 ataaatatag atgcctgcct gtagctccag ctactctgga gggtgatgtggaaggattgc
21421 ttgagctcag gagttcgagg ccactgtact ccagcctggg caagagagctaaaaaaaaaa
21481 aaaaaaaaaa aaaaaatttt ttttatgtta tcttagttca agtttgagaaataaaattaa
21541 gtaccaaatt tattcccaaa aatgtatgct tgtcaggaga tatacctaatgttaaatgac
21601 gagttaatgg gtgcagtaca ccaacatggc acacgtatac atatgtaacaaacctgcacg
21661 ttgtgcacat gtaccctaaa acttaaagta taatttaaaa acaaaaaacagaaaaaaact
21721 acagattcaa ttcagcttta ggaattaaaa aaaagatttg atgtaattatatcattataa
21781 aatcaaattt tttaaataaa acatgaaatt gttttaattt aaaaaaaagtatgcttggcc
21841 tatatgtcaa ttcaatagct tttctttgcc agaaagaatg aagtcagtctacctgtatcc
21901 acatatgaag tattttagga ttttttgtaa ttttttgtta ttatctatatcattcaggtt
21961 taggaaagaa ctttacctaa aatactggct aattgtgccc caaaaaaaagaaagctagaa
22021 agaaagaaca cacacacaca cacatacaca catatacaca cacaaaaaaaacaaccaact
22081 gatcaactgg gagtttcagg tttatcagcc tttagtctca atgctgtatcactgtagtaa
22141 aaatcaggct acttgatagc acctagaaac ccattttaaa atataaacttgtaaagcatt
22201 tctgtaagta aaagttagta tgtttataat gacatttttt cttttaagacatctttatta
22261 ttatcataaa aaatacagag aagcaaaaat aagaatgtag aaatcacccagtttttcctt
22321 tccaagtaaa caatcataaa aaacttggtg tatatatata ttgcagcaattgtatgtatg
22381 taatggtctc tgtatcaacc aacacatttt tatcatttta ctgaaacttttgagtgttgt
22441 ttgatgctga tatcatggtt tttcatgtgg gaagattcat atgagaattgattgtgtgtg
22501 tgtgcgtgtg tgtgtgctcg tgtgcgtgta gcagcaggaa gtatataaaattattttctt
22561 tttatagacg ctggttgaga tttttcaaaa tattggtgat accaatcttgctgatttcac
22621 tgctggattg ctcaccattg tcgtctgtat ggcagttaag gaattaaatgatcggtttag
22681 acacaaaatc ccagtcccta ttcctataga agtaattgtg gtaagtagaatatgtagtta
22741 gaaagttcag cattatttgg ttgacaaaca aggaattatt aaaaccaatggagtttttaa
22801 catcttttgt tttatttcag acgataattg ctactgccat ttcatatggagccaacctgg
22861 aaaaaaatta caatgctggc attgttaaat ccatcccaag ggggtgagtgtggtgttcct
22921 cttagtacta atacattaag tcagtaagtc agtctttttt atttaaataaaaccttttat
22981 tacaagcttc atttcactga tactccttca atagtcctat ttgtgtgtgatctggaagaa
23041 acaaccataa gacaaacagt atgtgtgtag ataaacgtca agccatttgtttaaaagcag
23101 cccgtatatg ctcttttttc ttcattttct taaaacatgg cagaacatgtacggttaaca
23161 ccagagtcct gatttaaact tatacataac attataatat aatataaatagaatcatttc
23221 tcagtaacat ctattgcact gtgaacaatc tgcttaagga atcagggacgtctggcctaa
23281 attctctatc atttagttta atcaattttg gataataatt atatcctcgtacccataagt
23341 aaaatgcatt atcttcaagg gaagttttag aaacatttgg tagtttggtgaattagaaga
23401 gtaaaagatc aaggtccttc attcatctct gtcaccttcc agttttgtgacctgaggaga
23461 ttctcctata taagacaagg ataatgaaaa cagccgaagc ctcaactcaagcttattatg
23521 aaacaccagt gagatctctc atgaaatgaa gagtagtcaa gacaccctacaccataattt
23581 tctcatatgg ggttacaaag gaggcctaga cgtttattat atttgtaacatacactcata
23641 acatttaaga ctagacttgc tgttaatcaa gaagtactag ttttccctaagactggaaga
23701 gtttggtacc ggtgtttcta ccaggaaagg gagtggaggg gagggaagggcacggagcca
23761 ctgtttggta ccagtgtttg ttttccatgc tcttaataga aacttcctcaggcaagctta
23821 ttcccagagc ttattctaca gggaactgct gtattcccat ttgatgaatcttataatttc
23881 ctctaatatc tgttccaaac tatttgaaaa agcacagctg gctacatgggacttaatttg
23941 catgctatcc attacagtgt ttctcaaact tacccttttg taagaatcacatgggatcct
24001 ttttcacaca gattcctggt tcccacccca aacctattga atcaggctttccagaggtgg
24061 ggctcaggaa ttaatatttt tcaaaagtgc ctcaagtgat tcttgccctcaaggaaactg
24121 gagaaactct ttaagagagg atcaacaaat ctaatctaac aactagataatttcattagt
24181 tagaaacaat tacagaaaaa gatactttac agatctcttt tgtcaggcttcctaggatgt
24241 atcaagttat aggtggtcca cagagcaggc cctgtcccat ccatccgtgttccattagtt
24301 ggtttaggga actcatttct tctgccctaa attatccctc caggtcctctgcagagcttt
24361 cctgtgctct cctcctgaga acagatttct agcctctcgc ccttgagtttaatgaagctg
24421 aatcctttga cagaccacct ggtcagcttg gtcagctaat ttaacctgcctggccccagg
24481 gactttaagc tactccatga gggcagtgac cccattggtg ttgttcagctctgtcccaga
24541 gcacagagct catctcacag taagctctca gaaaacactt gttgaaggaataaaataccc
24601 aagcctatgt cattataaac aagccacaac aaaggccttg gttatctgatctcacttggt
24661 agcacagaag caattctgat gatattaaca aacctgaaaa agaaagggagtggagagatt
24721 ggaaaaaagc aagcagagtt ttaaagtggc cctgaggtga gcacagtgaaaggaagaggg
24781 acagagagat tgtgatatgc ccccttttga tctcctccct gcttcaatcctccattaagg
24841 ctgctgctcg tagttccctt tatcctattg agggtccata agttaggatcactcctaacc
24901 taggaccata cgttaggacc ataagttagt ccccaataac aatgccccattggacagcca
24961 aaaacagtgg ctccatgccc ttccctctac tccctttcct ggtagaaacatacaactttt
25021 ccttgtccag tcaacaccta agcgccccac taggattcac tcattctcccatcctgggtg
25081 ctttcttaac cagcagacac tatgagggcc agtcatgtgc ctctcttctcatgcaactgg
25141 tccttatctg caactcgtaa tctgcccagt tcctcactca tcctgcccaggcttctcttt
25201 tacctcttct gttatagtgg tgtgtgtgtg tctgtgtgta tgtgtgtgtgtgtgctcacg
25261 cacgtgtatg tgtaaaccca taacaagatt gacagctctg tcctctaaattttaatccct
25321 attcactctc ttgcctcctg tccttgccag ttccagaggt ccccttgttgtcatgtttgt
25381 tactctcttt tttcttttct tttctttaac agagtctcac tctgtcacccagcctggaat
25441 gcagtggcat gatctctgtg gtgtgtgtgt gtgggtgtgt gtgtgtgtgtataaacccat
25501 aacaagattg acggctctgt cctctaaatt ttaatcccta ttcactgtcttgcctcctgt
25561 cttcgtcagt tccagaggtc ctcttgttgt catgtttgtt actctttctttcattctctt
25621 tctttcttcc cttccttccc tcccttccct ccctttccta ccttccctcccttccctccc
25681 ttccctccct ttcctacctg cactcccttt cctccccttc ctaccttccctccctttcct
25741 ccccttcctt ccttccttcc tctctctctt ttttctttct ttctttctttctttctttct
25801 ttctttcttt ctttctttct tttctttctt tccttctttc tttctttttcttttcctttc
25861 tttccttttc tgaaacagaa cctcactctg tcacccagca tggaatgcagtggcatgatc
25921 tcggctcact gcaacctctg cctcccaggt tcaagcaatt ctcctgcctcagcctcctga
25981 gtagctggga caacaggcac acactgccat gcctggctaa tttttagtagagacggggtt
26041 tcaccatgtt ggccaggctg gcctcaaact cctgacctca ggcgatctgcctgcctcagc
26101 ctcccaaagt gctgggatta caggcactgt tatagacccc ttttgtcaggtttcctagga
26161 tgtatcaagt tataggtggc ccgcagaaca tgccctgtcc catcaatctgggttccattc
26221 attggtttgg ggaactcagg cctactgttg tttttaaagt atgtgctttgcagttgtact
26281 tgaaagtgtg gcacaggggc aaagccaaca aaaccacagg gtttttttcctggctgcttt
26341 ctgagggcta ctcttctcct ctagctggag tggtggtgca tttgccaagtgttcagaccc
26401 agtctgaagt actctggtat tctgtttggt attctgttta tgacgctggcctgtcgtttg
26461 tggaattttg ggcccttcag ggttcacttc tcccggtctt catcttttcagataagtgtg
26521 tgttcacatg ctcactccct tgggctcttc atagtgttgt cttatgatcaggcctgacat
26581 gcttggctgg ggccaaacag gcccactgag caaaaaattt ggagagttatatccacagaa
26641 ggagggcaag ggcaagggca aggacaaaag gcttacttac aggtcattagaagatatcca
26701 gacgggactt caattggttt ggggcaaata attggcacac ttagggttcagcaagacagc
26761 agacatgagt ggcaggagta tgacagactt agattctccc aatatataccaagaacctac
26821 tatatgtgta gacactaatt acttacttac acaagtgatt cctcattgaatcatatgaga
26881 agaatatata gtccccattt gacagctgag gaaactggga tgtggtgggtttaaataaca
26941 tgcctaaagt catttgagag tgattctggt cctttgactt aagtctttgcactttacact
27001 ttgcacacct ggataatcaa ggatcaggtc atatttggag aactaggcagccaggcaggc
27061 aaagtgcatt aggctgctat caaaactaag ctgtatgtga aactggaaagttatcctgac
27121 aagtccgagt gacctgaagt agggttgact gggtctcagg agcaagtcaggagcctgttt
27181 tgagaagtgt ggtcccaagt cacatcccaa ctagcaggtg atgtcatgctgagtcgccca
27241 actgttggat cagggtttcc aacatcctgt ctgtctacag atggggttcattccacagtc
27301 tcattgtggg gtaggatggg atataaggag aaaaggagtc tgaaaattaacctcactggt
27361 agggagagta aggctacaag ggcagagaac cagacagatc ttgttaggtaggaaatcgtc
27421 taatatctaa catttagacc tggacccact aactgacatc aagcaaatcacttcacgttt
27481 ccaggtctaa gttcctttat caacaagaca agacaagagt ggtggattcaacaataccta
27541 ggatgctttc tctatggttt tctctaagaa ccttatttct attttatttttaccactgtt
27601 ctctaattat aggggaaaat gtagtttcct tattaaagaa actttaggcataagtgatgt
27661 aggtcgggga gacctttcat ggctgggggc ctctggaatt ataccatatggatagtcatc
27721 aagatatagg tccatctccc aaattttcat atttgagaga acctcgtggtataatgtgta
27781 ggttaatttt tttatatggt ttgtagggta gctctggttt tgtcaaacagtagtcattgg
27841 accccacaat cactgagata ttttagtcac tatggagcgt tgtgataattacattaattt
27901 aatctttttt gccttaagaa gattttaaat gtcctggctc tcaaaggattttccactgag
27961 ctcttttagc ttcatacatt ctttgtctct ttaacagagc tgatacctcttcaaacacag
28021 taaatctcat attatggcta gaatctcttt taaattcaaa gaactttaagatggaattgt
28081 ggaaggagaa acactaacat gtgaaatggc atggatgggg ctgtatgatattaaagaatc
28141 agtaacagca gatttattca tgtgagagat agagaagagt cagcatggctaggctcaaaa
28201 atagaggaca aagaaatcag ccagtaagat aacaccaact tctgattaaacattataaaa
28261 gctgctacta tcatgtatgt atttcgtgtg ctttttgttc ttttggatcaagtactttca
28321 tgtctaatat gtgactgagc agatatagca tttgatgaga tggggaaaaaggatggtggt
28381 caaatcttca cagcattttt cacttaaaaa ctcactaggt ttttgcctcctgaacttcca
28441 cctgtgagct tgttctcgga gatgctggct gcatcatttt ccatcgctgtggtggcttat
28501 gctattgcag tgtcagtagg aaaagtatat gccaccaagt atgattacaccatcgatggg
28561 aaccaggtat gggtgccctt ttgctgaact ggttttatag ggctggaaacaggaaaaaaa
28621 cataaatgga aaagattttg gtgtcagcta aagaaggggt tggattctttcaccagacct
28681 tattgggttg gttttcctct tgtgtttgct aattagaaat tattttggaatagacacact
28741 gcatcacttt gcttttttaa gaaataagtt gaaataacac taattttaaaagagctaatt
28801 cagtcaggtc ataaataaca ttcaaagtga acatattagg tcagaaagagaattcttcat
28861 gtaacccagt acctcttggc aattattttt aacggcagtt ataatgtgacaaaacagtgc
28921 aacaaacatt aataatagtt gtgaccactt taaattgagg tggttcactgtgcagttaat
28981 atatacaggc aatttttgta ggcatgtgat acattgccag gtaagctgatttcacactgc
29041 ttgcaaattt gcaagttctg tatctatatg tttctgaaaa tacagtatagcaataacagt
29101 agttaaatgg ttagtaatca agcagaataa cagcactgct agtcataatatgcttcatag
29161 tgaatattca accacagaaa aacactttat gtgagagctg cagacattccattcactagg
29221 cagtgaaaaa gcttagcaaa tgatcaggtg ctatttcttg tcaactttaaaaattatcga
29281 gagcaatgag acctctctca gatggtatgg cgtccaaact cctgatgtcgtacaaggacc
29341 ccaagtacct atcacggtaa aaattaaatt ggaccaccac gcagagtaggcatgggagtt
29401 ttcattctta atgtacttcc tgaaatactc agcgaaggtc ttgcaaagattcaatttgta
29461 ggatcgttgt catccagtct cttccttagg aattcattgc ctttgggatcagcaacatct
29521 tctcaggatt cttctcttgt tttgtggcca ccactgctct ttcccgcacggccgtccagg
29581 agagcactgg aggaaagaca caggtaggaa caacagcctt atgatatccatctcagagaa
29641 caagtcgagg aatggcaaca gaggaaggct cgcaccgagc ttagcaggacaatttgcctt
29701 tcagacttgt acttcctaat ctgattcacc tcaggcctat tcctcttgttccactccctc
29761 acctgaaatc tcttaaaaaa caacatgtat ggttttctga tacagtgattctcaaatcta
29821 tttgtcagtg cttacctgtc atgtagctac acttacctgc tgtggtcaataacaactgac
29881 aaggaatcag taatgaagga tgctgatttt tgttaatttg ttacctggggagacagatgg
29941 cctggtaaaa gcgcttcctg gctttaggag ctattctatt ttcaggaaagtgaaaagctc
30001 tattcacatt tcctttagaa ggatcaggaa cttcctccag gggcgtttggtcccacagaa
30061 caacagtttg ctagccaaga atatttttgt tgtaacattt ttggcatttcttcctgagta
30121 agatttatgt tgttgaagtt ctgcatgtgg gtttaatctt atcttttaaatgtggtttgc
30181 agttgttgcc tttacaaggt ggccaaaaag ccagcatcct agttaatctctggataatcc
30241 ctccttcagt gttcagaaag ctcaggagcc atactcaaag gccactctttccagcaggac
30301 acagtcgaag agaccacacc aagcagatgg gcacaagaga cagactcaggaattttgctt
30361 ctgtctctta tgccttgagg tccttatctt cccaacacag aaagaactattatttaggag
30421 taagaagtgc attgagactc caaagaacaa caaacccaaa ctacatagtgcaatacacac
30481 acacacacac acacacacac acacacacat gcacacacac atgcacagtcttcacagtct
30541 tcaaatgggt tttactaagg cggggacact taaaaaataa atataagtcgggcacagtgg
30601 ctcatgcttg taatcccagc actttgggag gctgaggtgg gcggatcaattgaggtcagg
30661 agttcgagac taacatggcc aacatggtga aaccccttct ctactaaaaatgcaaaaatt
30721 agccaggtgt ggtggtagat gcctgtaatc ccagctactt gggaggctgaggcaggagaa
30781 tcacttgaac ctgggaggtg gaggttgcag tgagccaata tcgtgccactacattccagc
30841 ctgggcgaca agagctagac tctgtgtcaa atatatatat acacacacacacacacacac
30901 acacacacac aaacatatat atatatatat attctcatat atatatacgagaataactga
30961 aaaaactaat gactccaaca gtgacttgcc cagggagggc tttaattgtccccaatatgc
31021 atgtgatgct cctttcctat ttataatgga tcttgtgaca gacttggaagaattggcctc
31081 ttccagtttt ttggctgctt ttcaacaaaa aattttattt tcagaatttttcttaatttt
31141 ttattttttt tgcaaatatt tccagctctg agggagcagg taaaataatacagctcatat
31201 ccggaggcat agccagagat ctgtggtcaa ggggaagagg tcagagccaatttccaaagc
31261 tgtgcacatt tcaggctgca gctgtcagca gcaggaactt ctgctgctttcatttgagac
31321 ggagcactga caagctctcc agagcacatg gtcttcagcg ggtgcaggcaaatctcaaac
31381 tgctgatgtc cattctcctg atgttacctc caggctcaaa tgaggcatgggctggctgtc
31441 ccagtaagta tgcccatgta aagtgacctc cttggcacag ggtttgggggataatggtgc
31501 tctggtaagc taataccccc tgccacatac tggcatgtat tatatttaggaatgaaggat
31561 gccaggattt cagcattaaa gaatgaaacg agtaaagaaa tggcttcatgtttaattatt
31621 gaaatgtata ctaaattctg gggttaaaag tctaagtgcc tgaactgaaatccagggact
31681 gatggacaaa taaactggca gggcttctct tgtgtggctt ctcgtgttttctcttatgtt
31741 ggaacttcag tttcagcatc tacaaaatgg aaatgataat tgcatccatttcacagggat
31801 attgtgagga ttaggcaaga aaatgtaaag ccttagcaca tacttgtaaatgctcattgt
31861 ttcactcctt taggcaagaa tagcatctta gcatctatga tacatatattgtgcctggca
31921 cataagaagc acctggcata tatttgctga atgaatgaat ggaagaatgagtattggtgg
31981 acacgaactg tttttagcac atctacagat tgtagaagaa ttaaacattggaaccttttc
32041 tttccctcac ccccatctga cttccactga ctcacagaaa agtaattctgattacaaacc
32101 actctttagc tctgattacc ccctccctta acagaataat tttttagtaactgaatctgg
32161 ttgtagatat aaagtctaca gagtttctca caaacaagcc ttatcaagtaagtagaaata
32221 attgatcact caccaatttt aatatagtgg ccaaaatgag ccttggcctcccataattgg
32281 agactcatta tgacatataa ttggcaagta ggtggccact ctcctggcatgagtttggca
32341 gctgactgtg gtccttgtcc ccaaatctcc atatctttct ccagttcacagagctcccca
32401 tccacagtga gatgcaagtg gctcggtaaa tactggttga gtaattgcatgcaaggaagg
32461 aagggaggga taagggaagg aaagaaagaa gaaaatggaa ggaaggacaagggagaggaa
32521 gggaagggat atgaaggaaa gcgaagagaa gggagggaag taggatatcagcttctctgc
32581 ttagtcagga gaagggaaag agcaccaggg tactgggaat ctaggatggggataggaaga
32641 gcatagaaaa gccagccaga catacaaagc acgcttttta gtacctcatacacatcatat
32701 tgcctcaggc tgacccaact ataatctaaa tataaatgat caatttgccaggtagagcaa
32761 gtgctttcta attttctgtt tatatttgct gtgtctgtct cccgtaactcagaccttttg
32821 cactagacag tacttgtgct caacaaaatc ttcccagttg tttcctctctgattgctttg
32881 cttgtagttc cctgtctcct tttcttcttt gtttcagagc ttctaatcttcatcttggct
32941 ctgccccagc tgtctcaaca gagaattcat tggtcatcta atcaaacgagagagtagtcc
33001 ccaccccctc agcctctctc ctaactagta tggatcttag gagagctatttttgccagcg
33061 aaggtaaagt ttctgaagct tccttttacc cctgctattg ccccgttactccatagtcac
33121 tgtttcaggc tgccttgggg caaagctctg agcctgcctc cgtggaactgtcagaggagg
33181 caggagacac aatcccacct ctcaatgtgc aaatgtggca tttcgaatttgcaataggat
33241 gagtaaattt attttctctg agactttaat gagaccatgt gctacaagtacgaagtgtta
33301 tcagagttgc tattatagct gcagcttcaa taatgcagaa aaatcagctatgtgccatga
33361 gaatttattt cccaagaata cgacaatgat ctctgttgtt gggaaaggggggattggtcc
33421 atgtttcctg ccatggtaaa taactagaag cttggcctga atggacgccgaaaccgcagg
33481 tgtgtactat caccaaataa aatccctgtc aaactggctt taatttcataggatcagtcc
33541 ccatattttc tttaacttct ctgccatagc atatatagat gccatttttgttcagttttg
33601 tggcttgagc aaataactat cacttttctc gacagtattg agcagaagggggagacaggg
33661 aagtatgaag tgtgtctgtg aacaggctgt ctcatacaca catccagtgagctggaagac
33721 acaagggaga aggacgaatc cttttcatag gaggtgtgtg tcttccaggttgctggcatc
33781 atctctgctg cgattgtgat gatcgccatt cttgccctgg ggaagcttctggaacccttg
33841 cagaaggtat aaccctgctt ctctgcatac cgattgcata atttcccttcactactctgc
33901 taccagataa ataacaggag atttaacaat catcacatgg aaaaccattccctgaataac
33961 acagccttct ctgtctctct tggcagtcgg tcttggcagc tgttgtaattgccaacctga
34021 aagggatgtt tatgcagctg tgtgacattc ctcgtctgtg gagacagaataagattgatg
34081 ctgtaagtca cctaccacct atatttatct gaaataagat ttggttcttatatgcttcct
34141 gccatatcac tatattcccc ccatccccta agtctcactt gtgctttgggaactccagag
34201 gagaaattag aattgtgggg ataaatcaaa gccatgaagt cttccatgtgaactgcattt
34261 tgtgaagatt ctgtatctct gggaaggtca atttccagca agaatcccatatgaggctca
34321 ttcatacacc tttggccttc taaacacaaa aagcaaaaaa atgtttaaacaccctagttt
34381 agaaggacaa acaacataca aaacaatgca aaaacaaaatacaaaatgtaaaaacccacg
34441 ctgactttaa ctctgactaa cataaccttt gcaactattc tgagaaactaaaaatcagaa
34501 gctaaatcct tcagagttcc tctctaattt aaaccataaa aagaatgagaagacttccta
34561 catattgata tggaaaattt tccaagacaa atcgttaagt gaaaaagagaccagaataga
34621 aatgctgggg aaaagcacag acacaggcag aaataaaagc ggatacaaggagggagggaa
34681 gttgggaatg ggtggagaag ggggagggtt gtgagcaaga gttttcccctttttaatgat
34741 aattccctta tgaaccatac aaatatatta gctattcaaa aatttagaaataaataaaat
34801 gggacagttg gtcttaattg agaagcccag tttctacagc tacttaaatataaaatgaat
34861 gaagtcacaa tatttttaaa aagctgtgat ttggccaggc acagtggctcaggcctgtaa
34921 tcccagcaat ttgggaggca ggaggatcac ttgagctcag gaatttgagaccagcctgcg
34981 taacacagtg agaccttgtc tctactacaa ataaaagatt aaaaattagccgggtttggt
35041 ggtatgtact tgtgggtagt cccagctact tgggaggctg aggcgggaggatcacttgaa
35101 tccagaagat ggaggctgca gtgaactatc atggtgccac tgcactccagcctgggcaat
35161 agagtgtgac cctatctcaa aagaaaaaaa aaaatgtaat ttgtttgtggatcattgatc
35221 ttatttttat aggtagttat cacatgatgg tacctgatac attaatataattcttttcat
35281 ttctattttt ttccctaggt tatctgggtg tttacgtgta tagtgtccatcattctgggg
35341 ctggatctcg gtttactagc tggccttata tttggactgt tgactgtggtcctgagagtt
35401 cagttgtgag taacgtaaaa cccagatttc ctataaacag aacaacacactctgagcttc
35461 cttataccat tttgataaat atagtgaagc cactttcttt cgttatagttactgtatatt
35521 gagtgcttct atgcattaag cagacagtgt tttacagaca tacttaatcttcaaaaatag
35581 cctatgaata gttttgatta gtctcattct acaggtgaga aaagagaaattcagaaaagc
35641 taagaagcat ccctaagatc acacagctag tacgtggcag agctaagatttgaacctatg
35701 tacctactca tgtcctctac tgctgtgctc tccttttagt tgtggtaagactaaaaagta
35761 catagtttag ccaaaggctg aagttgcttt gtagtttctt ctttaaatgagatgaggaat
35821 gtaaggcgct cggccccagg cttgggacaa gacagctgtt atatattatagttcattttc
35881 ttttttaaag ctagtaacca aaagttacat aacccagaac aggaggactttaaaatagct
35941 gatgacagcc aaaattcatt caaatctctc atataaccaa taaggcatataaccaataaa
36001 ccacacaatt atgtgaagga aacaattagc tcatatgcag agtgaaggcagcaaagacat
36061 gatttaaata atggaaaaca gcctgtgagg gaaggtgagg agcctgaaggtggttttttg
36121 gttggttttg ttttgattct agagaggcct tagttaagtg ccctcctgggcctagagggg
36181 aacagagtct ttctctccct cctcaatgtg tccatcgtct ttccagacttctggcccctg
36241 ctctgcctgt gcttgggccg tgaaagaaga agacacctgg aaaaacatcaagatagatgt
36301 cttcagctta gcatccgctc acctctcctg tcccaccagc cagttctccttcctgccctc
36361 cttccctacc ttggcatatt ggtgcctacc caaaaggctt gtgttttctacctcagcatc
36421 ctaaatgatt gcccaagggc ctgagaaggt ttgcaggctc ccaaagttctcaatttgctt
36481 ctaggacacg tctcagaaac gctccttaga agatgctgtc tctcatgctgtatatgcctc
36541 agtgtctatt ttttcttgtg tggatgtggt tggaaaagaa gggttttacagagagagatt
36601 agcttataaa cttttaagtt aaaaatcagc acaaacctgt aagccaaggaataactggtg
36661 gcacatttta gctgctagtt tggtatctag gcttttagcc aacaaaaagcagtatcctcc
36721 acagtattta atttccagta attatcatgc tgatccagag agcacaatgctgaaagtaca
36781 ctaaacagat actctttctt caggaattgt atttagcatg tctctagtcacacatgaaga
36841 gtcacggaat ttatctgatt gcatcaggaa caagaaatca atagtctggttgacaggaag
36901 gacttatttc tggtcctcca gtctcctatt tctataaaaa atgactaagtcacaaagaag
36961 cgccaggcac tggaagaccc aggggttaaa gacagaggct ctgctgccctttacctccag
37021 gccttttctc acttctctta agaagtttag ttaacaataa aaatcaggataatactgatg
37081 acctttcagg gttatggcag ggcttaaata agatttcaca tgcgtgaaagctctatgctt
37141 atcctataac gtgttgtgca cgtgcaagta tgatgctcat tatttctctcagccatcaga
37201 agagaggcac agttctcccc tcccctgccg attccacaca aacaccagctgttcatttca
37261 gagttagcta caggaaaatg tcatctgcaa taaagacaga gtccaaaacaccagaatgat
37321 gggctcttta gtagctgttg tttttaactt tttattccaa aatacggctgttccaaaaaa
37381 tcttgacctt gatatttttt cttctagtcc ttcttggaat ggccttggaagcatccctag
37441 cacagatatc tacaaaagta ccaagaatta caaaaacgta agtacctttgtgagacattt
37501 gctggacttg ggtttactag cctgaagttt cagcagctcc attttacgtacaaggtagcc
37561 aaagggagaa aatgcctatt gggaaagtct gttagtccac agggagtgtcatgaaaactt
37621 ttgatccagt gcaccttctg acacccatgg cttatgtgaa ttttgtctatgctagctgaa
37681 tgtctttttt tttttttctt tttagatgga gtctcactct tcacccaggctggagtgcag
37741 aggcaggatc tcagctcact gcaacctctg cctcctgggt tcaagtgattctcttgtctc
37801 agcctccgag tggctgggat tacaggcagg tgccaccacg cctggctaatttttgtattt
37861 ttagtagaga tggggttgca ccatgttgcc caggctggtc tcaaactcctgagctcaagt
37921 gatttgcccg tcttggcctc ccaaagagtt gggattacag gcgtgagccactgcacctgg
37981 ctagctgaat gtcattttaa tataaaactg ttgtaagagg aatttaaaaataataggcaa
38041 tttctagatg ttcatccaaa attttgttta tctggtatat aattcttatcttctgtaaga
38101 ttttctttat tcagttctaa caagagatta tcaagttctc tatgaccaagaccttattat
38161 ttgacacttt gctttatcct tggtattaga agaaataaaa tatgacacaggaaatgaaaa
38221 acaaagaaat taaacatccc attgatggac ttgtgtcacc tgcaaataaaattgcttagt
38281 ggtgactagg ggaaacaaag ataaaaaagc agagaaagta aatcaagaaaatacaaattt
38341 agcaaataat aataataata atatcaaccc taggaagttg tagtctaattttaccttaac
38401 attaaaaaaa gttggacctt gaaactggga tttcagtagc tgctacttaatttatttccg
38461 tgatctttct gttatgttga gccaagtgcc attaagagct aaaatgatttagagattttt
38521 ttggctttgg ggagggagct ctaagctgag ttagggaatt ctgacttctaggctccatct
38581 tggtgagact ttgcccaagt cattcagcct ctcaggacct cagttttctcatctgaagca
38641 gctagactaa aattgctgat tcctgaagac tagaaaagtc tatgattctgtgattcctgg
38701 gttctatttt gggtgtggcc attgtatgtc agggtgagaa cagatgatatcataggcctc
38761 agttctgcaa atcccattga ttttgctttt tttctttgct acttttaaagaatgttagca
38821 aaatcaggag ggtcagtggt atgaacttca ggcaaatcat ggcactgttctaagcctcag
38881 tttcttttct ggaaatcaga gggttgaata aattgctttc taaggccctttctaactttg
38941 accttctatg agactgtaga ggtccaagag tttttgtaac ctgttgtctccctattcaag
39001 aaaagttgta gaggccgggc acggtggttc acacctgtaa tcccagcactttgggaggct
39061 gaggcgggtg aatcacttga ggtcaggagt ttgagaccaa cctggccaatgtggcaaaac
39121 tctgtctcta ctaaaaatgg aaaaattagc tgggtgtggt ggcagcacctgtaatcccaa
39181 ctacttggga ggctgaggca ggagaatccc ttgaacccag gaggtggaggttgcagtgag
39241 ccgacattgt gccactgtac tccagcctgc gcaacagagt gaaactccatctcaaaaaaa
39301 aaaaaaaaag aaaagaaaga aaagttgagt gctgctaccc agctcctctgagcaactgtg
39361 acttgactcc ttgctaagta gccagaaatg taattaaata cttgaggcttgaaattattt
39421 aatcccagac aatttctttt aatgccagat tgaagaacct caaggagtgaagattcttag
39481 attttccagt cctattttct atggcaatgt cgatggtttt aaaaaatgtatcaagtccac
39541 agtaagtatt ttatccctag aaatttgttt tctaacctct tttgagacttcattcattct
39601 acaagtattt actggggtcc aatcaggaat aggccctaga ccctcttccctttgtgtagg
39661 gcaatgagaa ttaaaatata acatccttgc cttcaaataa tttacagtctatttggggat
39721 taaaaaaaca catatgttaa aacccaggta gtaataacta tgccagacaaaaacattaga
39781 gatgtttcta ggcagaattt gagtaagttt caaataagta gtatagacagttgagagttc
39841 atagaaggaa gagatccagg ttagttggac taacaggctt tgtgcggcagttggctgaag
39901 gaaagaaatc atgtcaagtg tttgagaact atgtgagctg agagacagtggaaacatgta
39961 ttggaggtag ggttgcccag ttgcagcaaa aagtaaaata tactagtggaataaataagt
40021 agaaaatcct ggcaccaaat gccatgctat gctttgaact tggagtttgcctctaaatca
40081 gtgtttttct aagtgagttc cagggcaaac tgattcagag gaatgttcacagattttgca
40141 ataacaaaag ggctctgtga taccaaggga atttggaaaa cccagacttaaactaaagag
40201 ggtattttgg ggtgtgtgtg tgtttctgtt ttgtctttta ctgtcttggagcctttgata
40261 tgctactgtc ttctcagagc ttctgggtag gagtagggta gcctgggagtagacagagat
40321 ctactccatc agaccttaca atttcttttt tggcaggata gctcaaggaattataccctt
40381 tgagaaatag cctttccaga taacagttgc cattaataag ctttaggtgccaggcatttt
40441 aagtaacttg acatttattt ccaaaggttg gatttgatgc cattagagtatataataaga
40501 ggctgaaagc gctgaggaaa atacagaaac taataaaaag tggacaattaagagcaacaa
40561 aggtgagatg acatctttct tttccccctt aaattatttc ctttccctgatgagagcagt
40621 tagagggtct aaaattaaat ctatcctctt tagtatccag atgtgaatgaacaaatgaca
40681 tgtacgtatc aaagaacaac tgagctattc ttataggcaa gcgggagtggaagggaatga
40741 aataaaatca gcagcgctgc ctggaaacac aggatgtgat ttttttccccaccatgaaca
40801 gtgtctgcat tattttctat actttatttt tactgaaagg aacaaaataagtgcaaattc
40861 aatgccagaa aactacccac catagaaggc agtctaagtc cataaacttttggagctgtt
40921 aacttttact cagattcttc tggccagtgt atttcttggc aaagttccacaatcatccag
40981 aaaacaaaag tttcctggct cctctgttct cccagttttc ttcctagacaacatcaaagt
41041 ttgggctgag gtgaaaccca tccttaaaaa ttcatctcct tgatgtcttgcttaccaagg
41101 aacagtgtgt aggtcttttg gataatttga tatgaatggt tgaaagatttcaaatctttg
41161 acaattaagt tgacagtgtt ttcttcgttt agaatggcat cataagtgatgctgtttcaa
41221 caaataatgc ttttgagcct gatgaggata ttgaagatct ggaggaacttgatatcccaa
41281 ccaaggaaat agagattcaa gtggattgga actctgagct tccagtcaaagtgaacgttc
41341 ccaaagtgcc aatccatagc cttgtgcttg actgtggagc tatatctttcctggacgttg
41401 ttggagtgag atcactgcgg gtggtaaggt tctggttttc tgaattatacatttggagct
41461 ttggcaatag taaaatgatg tgggttgtcc agtattgcaa cagggcaaatacatgggctt
41521 tgtaattttt ctaggtgaat gcttttgtaa aaaagtgtaa tattttaaagcataggctct
41581 ggagccagac tacctggggg agatactggc ttcaccactt actagcagtacgaccctggg
41641 caagttgctt aatctgtcta tatctcagtt tcttcatctg taatatggaggtaatgatgg
41701 tatctacctt cacaggttgt tacaaggatt aaataagcta atagatataaggtgtttaga
41761 agagtgtctg gttcaggctg ggcatggtgg ctcacgcctg taatcccagcacttcgggag
41821 gctgaggcag gtggatcatg aggtcaggag ttcaagacca gcctggccaatatggtgaaa
41881 ccccgtctct accaaaaata caaaaattag ctgggcatgg tggcgcacacctgtagtccc
41941 agctcctagg aggctgtggc aggagaatcg cttgaacccg ggaggtggaggttgcagctg
42001 agattgtgcc actgtactcc agcctgggtg acagagtgag acttcatctcaaaaaaaaaa
42061 aaaaaaaaga atatctggtt caaagatact ccccagcaaa ttaattcacatttattatgt
42121 tttatctttc tgagaatgta taacaagtgg tatatgaaaa gaaaaaaatgggcaaaagtt
42181 tattaagtat tacatttcta tttgttatgt taacagcaac aggataaggaataccaggtg
42241 tatgttagga ctggaaaagc caggcattat taagaggtta gagtaggaagcaggtcagac
42301 atctggaagg tcaaagcaag agttgaggag tatgcaggat agaaacattaatgatatcag
42361 aaaccagtta tgcaagctga agttcattaa ttctgtcaac aaatagatgtgaaatgccta
42421 atgtgtactg agcactctgc caggcacaag agactagtga tgaagtagacacagtttcta
42481 cctacgtggg acttagcagt ctggaggaga aggcaaacat taagtcatcttataaataac
42541 aattgtagta agtgctccaa agaagatgaa taggacatca cctgaagcatcaagttcagt
42601 gaagcttcag gtaggtatca aaagggtcag gcagaaaagt aagcaggtcaagacaccaac
42661 aatcagatgt aataatataa agctgactcc taactgaggt tccacttagctaaggcttct
42721 ttgctacctc tataagggga ggaaatgatt ccaggatgtg ggtactaggtaggtagggta
42781 gagaagtgat tgtgcttggc aaaagagtat gagaatatgc tgacaggttctgttctagtt
42841 ctcttagcag attttgttat tagctcattt gaaatcactc ttgttctttgttgtacattt
42901 cactctaagc attggctgag atccattgta gactatattg gccagagagttcaatgaatt
42961 acttttgggg acagtcttaa catatttaat gccagaatat ttcccacacaacgaatattt
43021 actttcaaat attataatga cagttatgat agctaaagaa gactccaaactttatacttg
43081 aacagaggtc ttgatttgtt ttcctccata attctcaaat tctcttttattattgactat
43141 gggtcttgtg tcttgacttt ttaaaattaa atgtttattt tgacataattgtaaattcac
43201 atgtagttgt aaggaataat atttagatcc tatatacccc ttacccagtttctcccaatg
43261 agtaacatct tgtaaaactg tagcataaaa tcacagtagg acactgacattcaaaataga
43321 ggccttgact tttaggtcaa tagtaacatt ttgaacccga taagcatagccacacccata
43381 tctcttctcc aatcagcagg gcctatatta agaagcctcc tgtactctcttctttccaca
43441 aatgcttatt tagcacctcc acgctatcaa gtgctgtgct attgagcgctggatgttgcc
43501 atctcttgag atataatcct aattatacca ttactgtagt ttgaaaacctccatggtttt
43561 gcaataataa cctttcctta aagtcctgat taaccatgaa agtaataatgtttctcctga
43621 gcaagtaact gaatgctact gaattatggg cagataaggt tgttaattgttacaaactct
43681 ccttttttat ttttagattg tcaaagaatt ccaaagaatt gatgtgaatgtgtattttgc
43741 atcacttcaa ggtaaataca tatatctaca tatctacctg taagactttcccgtaagccc
43801 tttctcctat ctgggactgt ggtcacatta tgtctgaagg ccttttttttttttctttta
43861 aagatctcaa ttgtcattat ttgcagttct ggaatctggc actgcttcattccataaaac
43921 agaataagtg ttccaaggaa ctaagcagga gttcagtatt atacacagaaaaggccaaag
43981 acagcaaaag caagcaacaa agagtatatt agtccattca aagttactttcttgtaagtc
44041 agagacagtg agacagaaca ataggaaaat aatggattag ttaacatgaggtcatgtcag
44101 gatacttttt tgtatgagga ttattgcaga ggaagcttta ttattatgccaactggaaat
44161 ttaaactgtc ctgttttagg aaatttgcta ttacctctct ctcctgatttcttcaagtat
44221 cagataacaa tttagtttag gtttgataac ttgaaacttt agcatgagtgactccatttt
44281 gatttttagt cttgtctgtt gtcgtctagt gcgggagctt agtctaaaacaatggccttt
44341 tatttttatt ttttatttta ctatgtgcct gtgccttgca tgaccccaggatgggcacag
44401 ctgcttggcc cctgagccac cgaaggctgc tctactcctt cgttctggctactaaaagct
44461 gcaaagctct gggagggcaa agctcaagaa gactaaaaca atggcctttaccatttttgt
44521 ttgatgattt tccccgtttt gatcaggctc tcacctaggt aagagtgaacaaaatgtagg
44581 agatcagtgc tactctgtta ccatcatttt gggtttctgg tctcaggaggtcatgtgtag
44641 cttatggtgc cctcctcatt atcatgtatg tctctgagtt tttgttgtttcagagagaga
44701 ccattcgatg tctgacaggt ggctttttgg aaacatttaa aactttgagagggtataatg
44761 taccaggaag actgctatta tgactatcag ggagataata ccaagggtttatagtatgct
44821 ccttagccag gattctcatg aatcaaacca actaaaattg aatagcctgacaaggagact
44881 acctgtttta accaagaagt cttctctgta gtacctgatg tatttatatatgtggaacaa
44941 gaagtgtcac ccaactgcac agatgcttcc ttgttgagtt agcaggtaatctagcattcc
45001 atgactggtt aaattaaagc agaaagtgta agttacccaa agaagctactcattgtgaag
45061 ttttaactac agcactatcc tgccaagtga aagaggtagg cacaagtaagggaaaattaa
45121 aagggataag catcttatga tagggagtct tgttctgaca gtcttggagctgtctacagc
45181 atgaagttga caacttcttg ttttggtttg tagttttatt gtctctagttgtggcatcca
45241 gcattctggc gaactctcta tgtggcccac agtttaagca tgagattcatctcttgaaat
45301 ttacactgag ttgctcagct tcagcttaca gagcttcagg aactgagtagttcttggtct
45361 tcattggagt gttgtagcca gatattagtg aaagctaaaa gaattaagaatccagctcag
45421 tctacaggta gataataaaa actcataaat attgaacagg gctacagtctaagaacagtt
45481 ttactatgct tttcttttga accatatgtt tttctttcta tagtcacctccatttctatc
45541 aaagacgatc atggtagacc aatttgttta caaaataagt ttggtctcaaacttggcctg
45601 attgattatt tacacagtac agcaagaata actacatagg tgactcctttcaaatttgct
45661 ttgccaagcc tggcgaggta ttgcttgcct gtgagcccag ctacttgggaggctgaggtg
45721 agaggattgc ttgagcccag gaattcaagg ctgcagtgca ctatgattgtgcctgtgaat
45781 agccactgca ctatagcctg gacaacacag tgagaccatg tctccaaaaaataattgctt
45841 tgatagaaat tttgacaagg aatctcagat tggacttttt aaaacgtcttgatgctatga
45901 agtcaaacca aggcagacat taggctttgc ctgatgtatc taatatcttgaagttactgg
45961 gcctcccagg aaggaacgac tttttattca ctcattgtaa ggctagcagcccttgaagcc
46021 aggaattctg tgcacatttt caaatatgat attctattca aagccttgataatataacca
46081 atgttttcca attgtattct atttaaaaga acagattcta ttgaactttcatgtaaataa
46141 tcatattgcc ataaaaataa gaatactcac aaagagtttc caaattctggaaggatcagg
46201 tagagaggaa aagcaaatgt ttcaattttt gtttatgaaa gtatgcttaacaaggctggg
46261 tgcggtggct cacatctgta atcccagcac tttgggaagc caaggcggacaattgctttg
46321 agctcagagt ttgagaccag cctggcaaca tggcaaaacg ccgttactacaaaaaataca
46381 aaaaattagc tgggcatgga gcctgaggct gagaatcact tgagctggggaagtggaggt
46441 agcagtgagc ccagatggtg ccactgcact ccaacctggg tgacagagtgagaccctgtc
46501 tcaaaaaata aaaaaaaagt atgcttaacc aagtggctgt aaactgcagatagctttaaa
46561 gaaaaatttt ctttagatct ggaaaacaaa tattaaaaga accagcaatgtttcaaataa
46621 aaaagccata aaacctgtaa ttcttctcca tcagttcatt cagtctcatgtaattaattc
46681 ttgctctgtt tgatcttggc tggtagttta attccaacga atggtatgaattcaaagtta
46741 ttagaaacct gtatttgtca gagttctttt cattcttccc atataactctttgaagtcac
46801 agcactttag aattataatg gcttacaaag agctttcaga aaaagtatcagaacaaaaca
46861 attaactgtg gacaacaaga cttaaagtgg ctatatttaa agatctgatgtgagttaccc
46921 aattgacaag gatatttgga tatttctgtg gcacacaaca atttaaaataaccaaaatta
46981 tgactggtag catttatacc aagacctatc acatttctag gaatgttatataattttgga
47041 acatattaat aacatatcta taaaaatata gcacaaagaa agttaaacatcatttcttat
47101 tttaacagtg cttcccatat aatttaacct atcagataag gccatttggtttaacatctc
47161 tcttttacag attctttaag aaattccagg gtcctctgga acatcccaaagttagttcaa
47221 ggtcaaaaag acttaatttt gatttttgag aagtttgtca aataccaaaggtttaaaaca
47281 tttgatcaaa atcggatcat aggtcactat gaaataaaac caaagtgaaaaaagagttca
47341 aaggcaaaaa gcacaagaag agttatattg atgaaacatg aaatctctgttttctaggcc
47401 agttacctgg aagagaaaat cctctcacaa ttttctatta agagtaaaccaatcctctga
47461 gaaaactcta ttgttccaac acataggccc acactttagc cttccatcagtgtactttaa
47521 tattaatgct caatttttag aaaaacttat aaataattcc cttctacttttagccaactc
47581 aatcacataa aatttttcat gatatttatc ttctacaaac cttctacaacttgcttaaac
47641 cttcatttgg tcctatactt ccttttttaa aattggcatt gtaccttaggacaaagattt
47701 acttttcttt tctccttatc attttgacca tataaggtta tctcctatacaaaagaaaaa
47761 attactctct tttcaatttt ctttatctct tcatacttgt aaatttcttctcacatcttt
47821 cctacctagt ggttccttcc tgccttgttt tgatttcctt cataagtccatatttagaaa
47881 caacctttaa ataacctctg attgccaagc tagagttaag ttttaaataaataaataggc
47941 cggtcatggc ggctcacatc tgtaatccca gcactttggg aggcaaaggtcagaggatca
48001 cttcaggcca ggagtttgag accagcctga gcaacatggt gagaccccgtctctattatt
48061 ttttttttaa aaaacaaaaa gcataaaaac tctgagaaca ttttgaacccagaaagatat
48121 tacttccaat ttgtgccaca gagctggtaa tgtatggaaa tgtgtatcttgacagtgggt
48181 gggggtgggg tgaatattga caatgggggg atgttgttat gaggagagcaaagctggaga
48241 ttacttagat tccttagaac aggaggactc tcaagggtgt gagtctctgtgtgtttcttt
48301 atgaatgtat gtgtgtagga aagtgctaag gcttaggttg aattctttagcagcagagcc
48361 caagatgggg attcttgcac aagcgattta ttgagaatac atctgaggaaatttatgaag
48421 cagtgagggg agcaggatag ggaaggggaa gaagctgatc aaagacatggtttctgaagt
48481 ccagcgtaga tccctgattt cacagggagc accaccacag gaagagtaccagaaggttat
48541 gcctccttga ggcaagagga cctgctttct cccccagtaa tgagtcagtcagtggctgca
48601 ggccagccat gtgtggggat gaaacctccc agttctcttt atttacttatttatttgaga
48661 cagggtcttg ctctgtcacc caggctggag tgcagtggtg caactgtggctcactgcagc
48721 ctcaaactcc tgggctcaag tgatcctccc atctcagcct cctgagtagctgagactata
48781 ggtgcacaac cacacctggc taatttttgt atttttttat aaagatggggtttcaccata
48841 ttgcccagaa gttctgggtt caaagtgatc tgccctcctc ggcctctcaaagtgctggaa
48901 ttacagaccc agtcctcttt agatgacaca gctcccaacg ggcaagggaaagtctccaga
48961 gaagggcaca gctgtgaaac attggcagcc tggcccacag cagcaggaggatggatacac
49021 tggcttggcc aaagggacgt gatcgtccac aaggttgact acgaccagttatgggataac
49081 cattctatat actactggaa aagaaactgt catttcaaat ctgggtcacattttggataa
49141 gagaaaaata aataaataaa aggaggagct acaaaaactt agtataggttgatgctttaa
49201 aatttctttt cttagctggg catggtaggg tgtgccctgt agtcctagctaattgggagg
49261 gtgaggtggg gggatcactt gaacttggga cgcggaggtt gcagtgagcaatgatgccac
49321 tgcactccag cctgggcaat agaatgagac tctgtctcaa aaacaaacaaaaatttcttt
49381 tcctaggaac taacaaaaca ttgtgtcttt cttttgaaga ttatgtgatagaaaagctgg
49441 agcaatgcgg gttctttgac gacaacatta gaaaggacac attctttttgacggtccatg
49501 atgctatact ctatctacag aaccaagtga aatctcaaga gggtcaaggttccattttag
49561 aaacggtaaa tattcaacct ttctacagat gtatcttttc taaactatcatgatttctat
49621 aaatggcaaa cattacacaa gtctagtcta gctgttgaat tttaagctacctatataact
49681 tcatggagcc tcagtttttt catcagtaaa atggaagtaa aaacattaaccttgctaggt
49741 agatatgaag actaaataag atagtttata ggaaattacc tggtagtacccagtactgaa
49801 tagttctaca atgtgtaggt ttattaataa aagtgggcat tagctataatgccttttaag
49861 aatattgaat cttggatctt ttgtgatctg ggatttgtgt acataaattccacttaaatt
49921 ctcagcaatc tggaaaacct tgaattataa atgtctttaa acaggatccaccaggccata
49981 agtgatcttt gaaaaagaaa tttaaaaatc aagccacaaa gaagcccagggttaattttt
50041 ccctacaaaa tagaataggc cctgatggga ggcctcatgg cacaacagtagcgcatctgg
50101 ctccagaata ggccctgatt tcccatgggt attattttgt taatttttctgtcaaatacc
50161 cagaagaggt gagcattctg gtctggttca ttgggcttgg cctaatggtgctcctggtgg
50221 tacaagaatc tcatttctca tagtgaattt aggaaactaa agcaaatacctatcaagata
50281 taataacagt aatgattcca gtgacatcgt ggatatttta aattgcttcccatttttcta
50341 aaagtagaat aagtagatcc ttattgtaga ttggcagttg attgaagaaaactaacttag
50401 gaaatgatat tatattattc tttttaggca ctggtagtgg agagattgttctatttgatg
50461 ttccttggta aaatactagt cctaactacc aagctgtgga tcttaaatataaaaaaggaa
50521 aaaaaaaaaa gagtaaagct acaaatctaa agaaaaaaaa actgtttatcattgaaaatt
50581 cataaacttt ttctatccaa cttaaaattc tctaacccat aggtgataagaaagttggat
50641 catatgaagt atcctttaag agatccacat taaaagtaaa acagaaccaaggtatcaagt
50701 tctttctcaa catgaaagca gttattttat ttgtttatac ccattcttactaagatttta
50761 ggctatgaat gtcataaaaa ccactaacca agagtgtatc tactaggttagactcactct
50821 tgtttgcaat cagagaggta ttgtgagtgg ctgggatgga tttttttggaccttaaacaa
50881 atagactaag cataacggaa tgcttgtatt acatacttac tggtccactaaaagtgggtt
50941 ggacattcct ggtggcctgt gagatcaaga ggcttatatt tctgtgtcttctcagagtct
51001 agcacaaagc tttatatgtg ataagtaggt gaatgatgat aaactccttcaagagggagt
51061 ccctctgtat caaagatatt gtgactgcaa tgacacaacc ttcttcctatccctttattt
51121 taccatcaca ggactatctc aggacacaac ttgtagttag acttatcctctacctttccc
51181 attatgtcat accatttgca cagggactta accctctaat tcattctcatactagctaag
51241 agaattgggc tatttgtgag ttgaaaagta gctaagtagc atttcaaaatgttattttag
51301 cctggatata tatttggagt tgctttgaaa atgtcctttt ccatgcaaaacacaaagcca
51361 aaattgtcgt tggtttcctc tgtgtagaag attaaattac atgccacctctaaacagtag
51421 agcttttctg aataaccaac ttggtccata gacattggtt tccatctccaatagaattaa
51481 tttccaccca attccatttg tggctgtttt ttgtcatcag tgacaagctcttcactgtgc
51541 attcattgca cactcaacgc tgtgctaagt gctcttagct tagccattgagagatgcact
51601 attgactgct gaatcattta ggcagagggg gtgacttgtt aagaggcatacactcaagag
51661 gttggggaag agagctgaaa aggagtttac acaatggaga actataccagttcacctttc
51721 aatgtgcaaa aaaatgatat acaaaaaatt ttagttggga aatataaaagaacaatacag
51781 ctgaagagga ttctgaagta tgtaaagaca gatgagaagc accaggaaagcttcaaatca
51841 ttttcagtgg agcatcaggt gggttgatgc tattctattt ctaccctgtgttctcttttt
51901 caagatcact ctcattcagg attgtaaaga tacccttgaa ttaatagaaacagagctgac
51961 ggaagaagaa cttgatgtcc aggatgaggt atgatcattt tcttctgaagaaaatatttg
52021 aattacattt tgaataatta gagtaataca aatagtgaat atatctgattaagaactgtc
52081 agggaacata attcccccaa atgcagaaaa gatggcttca tagcagggaaaaagagaaaa
52141 taagaattct cccttgaaga cattaagtac ttggggatct tttgtcccaggcatttgggg
52201 atgatcagca actggcaaga gccaacacac tgctcctgat ttgatacctacacctctgca
52261 tactgctctt ctagagatgt aaggccatgg ggtaggaaaa aaatgaatagaggaaacttc
52321 taagctagga actttataag cctcaggaat agtatgtgag gaacagaaaccctatgacct
52381 tccttcatat gactgataaa ggctttaaaa acacactctc cccaccctagactgattctg
52441 tgtatttcag atgctcttgt gacatcagac tattcctagg aaacttgtctgaacttgtag
52501 catctgagta aattttgcag cttcgccact ggataagagg tgaacactgaaggaagatca
52561 cagaattgta aaaagttgaa agatttctta gaatcaagta gtctaacattctagcccatg
52621 cagaaatcct tcctacacca tccttgatga atgttcattc agcttttatgtgaacatttc
52681 cagacattgg ccactagcgg cttctcaagg gagtttgtta catggttggaagtctctaaa
52741 tgttacttgt gcttacagaa ctcaatttgg cctttctgta gtaaccacctagtgaactga
52801 gatctgcctt ccttagcaac acagaccttc ccactgaaca gcccttcaaatatttgagaa
52861 tagttctcat gtctccagca gactctcttc cagttgagac tcttctagttccttctattc
52921 cttacaaaca agcagtcagt gcttctctgg tcacgatggg gacacaaaaccctaaatgcg
52981 gccaggccag catggagatt attcaaccat gacctacctt gatctcatcaagatattcct
53041 attactacag cttaaaaatg tgtttccttt cataatagca acatcagaattttagcttct
53101 attgagcagg ggccaactaa agactggggc attttcatac aagctatggtctagtagagt
53161 tccctagtta tatttattta attgagcttt gaccctaata cagaactacacctatttctg
53221 ctggatttca tcttgttggt tcttgtttac tgacataatt ttgtattattattagtatta
53281 ttattattat tattatttgt gactgagtct tactctgtca cctggactggagtgcagtgg
53341 tacaatctca gctcactgca atccctccct cccaggttca agagattctcacgtgtgcct
53401 cagcttccca agtagttggg attacaggcg ctcgccacca cgtccagataattttttttt
53461 tttgtattct tagtagagac agggttttgc catgttgtcc aggctggtcttgaactcctg
53521 acctcaagta atccacctgc cttgccctcc cagattgctg ggattacaggcatgagccac
53581 cacattggcc agttttgtgt tttgaatcta acatccagga tattgtctaccccagtaccc
53641 gttacctggt gtcataatca aatctgataa gcctgccttc tctgcctttttctaggtctt
53701 gaaaaaatgt tgcaaagaaa acattcaacc ccctatagtg aaatcaggcagtaaggatga
53761 caggcagaga tttctgtgga ggaaatacat tgctagagtg aaaatcacagtacctgcatc
53821 ttggcccacc agcttagtga gcccaggaaa gtcattatcg acctgagaagtccttttagc
53881 tccagtagtt tatgactcta tggatatagg gtgccttagt ttgagtaaaaactcatatgt
53941 caacattaaa acttaagact gctatattat aggatattta ttggttgccacgtaaaataa
54001 tcattcaggg agggtttcta tagatggtaa aacaatatag cacaatagtttcaagggcat
54061 ggactttaga acaagacaga cctgggtgct agtcctcatt ctgctacttactggctgtgc
54121 accccagggc aaattactta tcctgtcttc atattagtat cttcatgtaaagtagtaata
54181 ataccacaga gttgtgaaaa ttaaaggata aatgtaaagt aacaagagcagtgccttgta
54241 catagtaagt gctcaataaa tagtaatcat tgctcttaaa taaatccaattaaagtgtga
54301 tgaatacagg ccaggctcag tgactcaagc ctgtaatccc agcactttgggaggctgagg
54361 cagggggatc acttgaggtc aggagtttga gaccagcctg actaacatggtaaccccccg
54421 accatctcta ctaaaaaaaa aaaaaaaaaa attagctggg tgtggtggcaggcacctgta
54481 atcccagcta ctcgggaggc tgaggcagga gaattgcttg aacctgggaggcagaggttg
54541 cagtgagctg agatcacgcc acagcactcc agcctgggca acagtgagtgagattcagtc
54601 tccaaaaaaa aaaaaaagta taatgaatac gaaatgaagt ttttaccctatttctattgt
54661 gatgatatac acctaagatg agtagcagta agcaatcaat actataaaaacatatttata
54721 aaaaagataa tgcagactta aggagaattc agttgtatca acactttgttttccccttgc
54781 ttccacaggc tatgcgtaca cttgcatcct gaaagtgggt tcgggaggtctctatgagca
54841 aggaatacaa gacaaaactt cctcaatgca ttgactattt cttcagactcaaaacactca
54901 ttcttttttc tattaagcca ttgaaagaga agcactaaga ctgcttctaggctttattta
54961 taaaataaac accttatccc taacatgggc aaaatggcta gaattattcagacgatttgg
55021 cagcgtccag ggtaagctgg tgttataata cgctgctgat ctacatcacagatttgctaa
55081 taatgttcac gtgggccctg gcatatctct gttcagttag agtgagtgctgacccaacag
55141 cctctgtggt caagcgagtc acgaatgatt aatcataaag aaaaatcagtttttgactga
55201 cctggatatc catgagctgc actgatcacc atgtaaggtc acatttagtaaatgctgaaa
55261 taaaatgatt aatgcattta tcaataaaag cctttgaaaa tactttggataataaattgg
55321 agttttaaaa atgcaaattt gcttagtatc taataatgaa gtgttattacatatagccgg
55381 aattgaggat ctctttgatc ctggaaatgg tttacctaaa agctacagaaccaggccaat
55441 atattttgaa atattgatgc agacaaatga aataataaag agattttcatggtttataaa
55501 aatctttttt gatatgataa taatcatgat cacaactgag atcaaaaaaatatatgacag
55561 attattttgt ttaaaaatgc agttttaatt atcttagtct atagaaatgatcattgcatg
55621 gaggcatgta taggtatgat ctgtgtaaaa tctgacataa aaacagtgctattctgagtg
55681 aaaatttttt tgatgtgctt acataaccat ggtgattaaa atgagtttatattttttctc
55741 aaaaatttta gcagtgtgta aagtaagtaa tctttaactg aactctgaccacttaaaaaa
55801 aaatctaaaa attgaactac ctatagtagt ctgtgtttaa agtgaatttttaaagacaaa
55861 gcattctaaa tgaactcaat ataaaaacat tcatttggaa tgtacatactgaaaaataca
55921 ggtttttttg accaaaagtt tttatatctt ttctttttat ttatttttttcctaagtgcc
55981 aacaattttc tagatattat atacaacaca ggctttgatc ttggggacttttcccatata
56041 tttcacactg gagtgaatga agttgtactt catttctaga gaaaagttatacccaggtcc
56101 ccaattgaga atgtcttgct tgattgaaaa cgacatcatc ccttggtatactccagggat
56161 tggtttcagg acccctgcat ttaccaaaat ttgtgcacac tcaagtcctgcagtcacccc
56221 tgcctaaaga tagaatggct tctctgtttt tcttctgaaa tacaaccagaaacaatgtgt
56281 ctatttctga aagaatagga ttaatgatca tacaaatggg ttaatcctgaattctggttg
56341 taaatctggt tacagcataa ctaggattat aatgctgcct cattttcacagcactacttg
56401 cttatattga caacaaatca tctcgctaaa gagtgaatgt aggccaggcgcggtggctca
56461 tgcctgtaat cccagcactt tgggaggccg aggcgggtgg atcacgaggtcaggagatcg
56521 agaccatcct ggctaacatg gtaaaacccc gtctctacta aaaatagaaaaaaagaaatt
56581 agcctagcgt ggtggctggc gggcgcctgt agtcccagct atttgggaggctaaggcagg
56641 agaatggcgt gaacccggga ggcggagctt gcagtgagcc gaggtcgtgccactgcactc
56701 cagcctgggc gacagagcaa gactccgtct caaaaaaaaa aaaaaaaaaaaaaaaagagt
56761 gaatgtaata gtcttgcaga aaatgaatga atacctttgt tcaataaaggaaatatgcac
56821 tgctcacttt tttgaaggaa atgccaaagt tacgttttac aacaaggctagagtttgtaa
56881 attctgggtt catttgtgat gacataagtc agcaaactgc gggaatactgtctcttctat
56941 gtattttgtg aatagtaagc ataattttag ttttgtatta tcaatgaaaatttcacttga
57001 aattaaagct gccttttgtt atatttttaa cctataggat aagattccagtattgtatat
57061 gagttttaac aaattaaaaa atcaaatcat gtacatttga aaatatttgcacacatttaa
57121 aaataaatgt aaagttgtct tttaaactac tcggatgtgt cctttctgaa caaaa
耳畸蛋白
迄今为止，已经鉴定出人OTOF基因中的数百个突变引起了严重的语前性耳聋DFNB9。此类突变是导致不同人群中2-8％的先天具有常染色体隐性遗传性非综合征性聋人耳聋的原因(Rodríguez-Ballesteros等人(2008)Hum.Mutat.29 823–831；Choi等人(2009)Clinical Genetics 75 237–243；Duman等人(2011)Genet Test Mol Biomarkers 15 29–33；Varga等人(2006)J Med Genet 43576–581；Iwasa等人(2013)BMC Med.Genet.14 95)。例如，耳畸蛋白的保守C2C结构域中位置490和515处的外显子15中的两个取代导致DFNB9(Mirqhomizadeh等人(2002)Neurobiol.Dis.10(2):157-164)。Migliosi等人在患有语前聋非综合征性听力损失的西班牙患者中发现了OTOF中的新型突变Q829X(Migliosi等人(2002)J.Med.Genet.39(7):502-506)。
患有听力损失的受试者中检测到的耳畸蛋白基因中的其它示例性突变和编码耳畸蛋白的核酸的测序方法描述于例如Rodriguez-Ballesteros等人(2003)Hum Mutat.22:451-456；Wang等人(2010)BMC Med Genet.11:79；Yildirim-Baylan等人(2014)Int.J.Pediatr.Otorhinolaryngol 78:950-953；Choi等人(2009)Clin.Genet.75(3):237-243和Marlin等人(2010)Biochem Biophys Res Commun 394:737-742中。
至少在生命的最初十年，DFNB9患者的耳声发射正常，表明内耳的形态完整性和外毛细胞的正常功能。除了缺乏突触传递和随后的突触损失以外，至少在人生命的最初十年中，DFNB9中保留了内耳的形态学和生理学。
对小鼠模型的研究表明，突触在结构上是正常的，并且IHC在出生后第一周内在小鼠中保持正常的突触数量。在P6与P15之间，约有一半的突触丢失(Roux等人(2006)Cell127 277–289)。动物模型允许通过记录囊泡融合后质膜电容的变化和听神经的活性来研究耳畸蛋白中的突变对突触传递的影响。在耳畸蛋白敲除(Otof-/-)小鼠中，通过去极化诱导的Ca2+通过电压门控的Ca2+通道流入，IHC中几乎没有胞吐作用被触发(Roux等人(2006)Cell 127 277–289)。在C2F结构域中存在随机点突变的严重听力受损的pachanga(OtofPga /Pga)小鼠中，IHC的短(<10ms)去极化引起了与野生型小鼠相似大小的囊泡融合，但持续刺激发现向容易释放的池补充囊泡存在严重缺陷(Pangrsic等人(2010)Nat.Neurosci.13869–876)。在具有仅轻度提高的听力阈值，但语音理解能力严重降低并伴有温度依赖性耳聋的人患者中发现的p.Ile515Thr突变(Varga等人(2006)J Med Genet 43 576–581)在小鼠模型中进行研究时发现了中间表型(Strenzke等人(2016)EMBO J.35:2519–2535)。当通过ABR评估时，这些OtofI515T/I515T小鼠显示出适度的听力阈值升高，I波振幅减小，但在行为测试和单个听觉神经单位记录中听觉阈值正常。RRP的胞吐作用仍然完整，但持续的胞吐作用减少了，尽管不如OtofPga/Pga中严重。在室温下在野生型小鼠中，在持续刺激过程中，每个活性区每秒可融合750个囊泡，在OtofI515T/I515T小鼠中，该速率下降至350个囊泡/秒/活性区，在OtofPga/Pga IHC中，该速率下降至200个囊泡/秒/活性区(Pangrsic等人(2010)Nat.Neurosci.13 869–876；Strenzke等人(2016)EMBO J.352519–2535)。这与IHC的质膜上的较低的耳畸蛋白水平相关，表明耳畸蛋白的量随胞吐作用和听力而变化(Strenzke等人(2016)EMBO J.35 2519–2535)。
检测基因中的突变的方法是本领域公知的。此类技术的非限制性实例包括：实时聚合酶链式反应(RT-PCR)、PCR、测序、Southern印迹和Northern印迹。
OTOF基因编码耳畸蛋白，一种在耳蜗毛细胞中参与突触囊泡胞吐作用的蛋白质(参见，例如，Johnson和Chapman(2010)J.Cell Biol.191(1):187-198；和Heidrych等人(2008)Hum.Mol.Genet.17:3814-3821)。
人OTOF基因位于染色体2p23.3上。其包含48个外显子，涵盖约132千碱基(kb)(NCBI登录号NG009937.1)。编码在大脑中表达的耳畸蛋白的长形式的mRNA包含48个外显子(Yasunaga等人，Am.J.Hum.Genet.67:591-600,2000)。Yasunaga等人，Am.J.Hum.Genet.67:591-600,2000的表2中描述了可用于扩增OTOF基因中的48个外显子中的每一个的正向和反向引物。在一些实例中，全长OTOF蛋白是全长野生型OTOF蛋白。从人OTOF基因表达的全长野生型OTOF蛋白的长度为1997个氨基酸。
示例性人野生型耳畸蛋白为或包括SEQ ID NO:8-12中的任一个的序列。人耳畸蛋白的异型体e(SEQ ID NO:12)由mRNA编码，所述mRNA包含耳畸蛋白基因的外显子48，并且不包含其外显子47(Yasunaga等人，Am.J.Hum.Genet.67:591-600,2000)。在一些实施方案中，活性耳畸蛋白具有SEQ ID NO:12的序列，但缺失包括Strenzke等人，EMBO J.35(23):2499-2615,2016)中鉴定的RXR基序的20个氨基酸。编码野生型耳畸蛋白的核酸的非限制性实例为或包括SEQ ID NO:13-17中的任一个。如本领域中可理解的，可对SEQ ID NO:13-17中的至少一些或全部密码子进行密码子优化以允许在非人类哺乳动物或人中的最佳表达。人耳畸蛋白的直向同源物是本领域已知的。
人规范(长)异型体序列(耳畸蛋白)(SEQ ID NO:8)(也称为耳畸蛋白异型体a)(NCBI登录号AAD26117.1)
MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDPLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA
人异型体2(短1)(耳畸蛋白)(SEQ ID NO:9)(也称为耳畸蛋白异型体d)(NCBI登录号NP_919304.1)
MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLLGA
人异型体3(短2)(耳畸蛋白)(SEQ ID NO:10)(也称为耳畸蛋白异型体c)(NCBI登录号NP_919303.1)
MMTDTQDGPSESSQIMRSLTPLINREEAFGEAGEAGLWPSITHTPDSQEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA
人异型体4(短3)(耳畸蛋白)(SEQ ID NO:11)(也称为耳畸蛋白异型体b)(NCBI登录号NP_004793.2)
MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKILGA
人异型体5(短4)(耳畸蛋白)(SEQ ID NO:12)(也称为耳畸蛋白异型体e)(NCBI登录号NP_001274418.1)
MALLIHLKTVSELRGRGDRIAKVTFRGQSFYSRVLENCEDVADFDETFRWPVASSIDRNEMLEIQVFNYSKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWDDGDFLGDESLQEEEKDSQETDGLLPGSRPSSRPPGEKSFRRAGRSVFSAMKLGKNRSHKEEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSAGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSGLKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMYGSTRNYTLLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDTSNPELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRNYFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGLLMLGLFLYSLPGYMVKKLLGA
完整cds(耳畸蛋白cDNA)(SEQ ID NO:13)(编码SEQ ID NO:8的蛋白质)
atga tcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggaggagctgagct gtggctgctg ccgcttcctc tccctcgctg acaaggacca gggccactca tcccgcaccaggcttgaccg ggagcgcctc aagtcctgca tgagggagct ggaaaacatg gggcagcagg ccaggatgctgcgggcccag gtgaagcggc acacggtgcg ggacaagctg aggctgtgcc agaacttcct gcagaagctgcgcttcctgg cggacgagcc ccagcacagc attcccgaca tcttcatctg gatgatgagc aacaacaagcgtgtcgccta tgcccgtgtg ccctccaagg acctgctctt ctccatcgtg gaggaggaga ctggcaaggactgcgccaag gtcaagacgc tcttccttaa gctgccaggg aagcggggct tcggctcggc aggctggacagtgcaggcca aggtggagct gtacctgtgg ctgggcctca gcaaacagcg caaggagttc ctgtgcggcctgccctgtgg cttccaggag gtcaaggcag cccagggcct gggcctgcat gccttcccac ccgtcagcctggtctacacc aagaagcagg cgttccagct ccgagcgcac atgtaccagg cccgcagcct ctttgccgccgacagcagcg gactctcaga cccctttgcc cgcgtcttct tcatcaatca gagtcagtgc acagaggtgctgaatgagac cctgtgtccc acctgggacc agatgctggt gttcgacaac ctggagctct atggtgaagctcatgagctg agggacgatc cgcccatcat tgtcattgaa atctatgacc aggattccat gggcaaagctgacttcatgg gccggacctt cgccaaaccc ctggtgaaga tggcagacga ggcgtactgc ccaccccgcttcccacctca gctcgagtac taccagatct accgtggcaa cgccacagct ggagacccgc tggcggccttcgagctgctg cagattggac cagcagggaa ggctgacctg ccccccatca atggcccggt ggacgtggaccgaggtccca tcatgcccgt gcccatgggc atccggcccg tgctcagcaa gtaccgagtg gaggtgctgttctggggcct acgggaccta aagcgggtga acctggccca ggtggaccgg ccacgggtgg acatcgagtgtgcagggaag ggggtgcagt cgtccctgat ccacaattat aagaagaacc ccaacttcaa caccctcgtcaagtggtttg aagtggacct cccagagaac gagctgctgc acccgccctt gaacatccgt gtggtggactgccgggcctt cggtcgctac acactggtgg gctcccatgc cgtcagctcc ctgcgacgct tcatctaccggcccccagac cgctcggccc ccagctggaa caccacgggg gaggttgtgg tgactatgga gccagaggtacccatcaaga aactggagac catggtgaag ctggacgcga cttctgaagc tgttgtcaag gtggatgtggctgaggagga gaaggagaag aagaagaaga agaagggcac tgcggaggag ccagaggagg aggagccagacgagagcatg ctggactggt ggtccaagta ctttgcctcc attgacacca tgaaggagca acttcgacaacaagagccct ctggaattga cttggaggag aaggaggaag tggacaatac cgagggcctg aaggggtcaatgaagggcaa ggagaaggca agggctgcca aagaggagaa gaagaagaaa actcagagct ctggctctggccaggggtcc gaggcccccg agaagaagaa acccaagatt gatgagctta aggtataccc caaagagctggagtccgagt ttgataactt tgaggactgg ctgcacactt tcaacttgct tcggggcaag accggggatgatgaggatgg ctccaccgag gaggagcgca ttgtgggacg cttcaagggc tccctctgcg tgtacaaagtgccactccca gaggacgtgt cccgggaagc cggctacgac tccacctacg gcatgttcca gggcatcccgagcaatgacc ccatcaatgt gctggtccga gtctatgtgg tccgggccac ggacctgcac cctgctgacatcaacggcaa agctgacccc tacatcgcca tccggctagg caagactgac atccgcgaca aggagaactacatctccaag cagctcaacc ctgtctttgg gaagtccttt gacatcgagg cctccttccc catggaatccatgctgacgg tggctgtgta tgactgggac ctggtgggca ctgatgacct cattggggaa accaagatcgacctggagaa ccgcttctac agcaagcacc gcgccacctg cggcatcgcc cagacctact ccacacatggctacaatatc tggcgggacc ccatgaagcc cagccagatc ctgacccgcc tctgcaaaga cggcaaagtggacggccccc actttgggcc ccctgggaga gtgaaggtgg ccaaccgcgt cttcactggg ccctctgagattgaggacga gaacggtcag aggaagccca cagacgagca tgtggcgctg ttggccctga ggcactgggaggacatcccc cgcgcaggct gccgcctggt gccagagcat gtggagacga ggccgctgct caaccccgacaagccgggca tcgagcaggg ccgcctggag ctgtgggtgg acatgttccc catggacatg ccagcccctgggacgcctct ggacatctca cctcggaagc ccaagaagta cgagctgcgg gtcatcatct ggaacacagatgaggtggtc ttggaggacg acgacttctt cacaggggag aagtccagtg acatcttcgt gagggggtggctgaagggcc agcaggagga caagcaggac acagacgtcc actaccactc cctcactggc gagggcaacttcaactggcg ctacctgttc cccttcgact acctggcggc ggaggagaag atcgtcatct ccaagaaggagtccatgttc tcctgggacg agaccgagta caagatcccc gcgcggctca ccctgcagat ctgggatgcggaccacttct ccgctgacga cttcctgggg gccatcgagc tggacctgaa ccggttcccg cggggcgcaaagacagccaa gcagtgcacc atggagatgg ccaccgggga ggtggacgtg cccctcgtgt ccatcttcaagcaaaagcgc gtcaaaggct ggtggcccct cctggcccgc aatgagaacg atgagtttga gctcacgggcaaggtggagg ctgagctgca tttactgaca gcagaggagg cagagaagaa cccagtgggc ctggcccgcaatgaacctga ccccctagag aaacccaacc ggcccgacac gagcttcatc tggttcctga accctctcaagtcggctcgc tacttcttgt ggcacacgta tcgctggctg ctcctcaaac tgttgctgct cctgctgctgctcctcctcc tcgccctgtt cctctactct gtgcctggct acctggtcaa gaaaatcctc ggggcctga
人耳畸蛋白转录变体1(SEQ ID NO:14)(编码SEQ ID NO:8的蛋白质)
atggccttgctca tccacctcaa gacagtctcg gagctgcggg gcaggggcga ccggatcgccaaagtgactt tccgagggca atccttctac tctcgggtcc tggagaactg tgaggatgtg gctgactttgatgagacatt tcggtggccg gtggccagca gcatcgacag aaatgagatg ctggagattc aggttttcaactacagcaaa gtcttcagca acaagctcat cgggaccttc cgcatggtgc tgcagaaggt ggtagaggagagccatgtgg aggtgactga cacgctgatt gatgacaaca atgctatcat caagaccagc ctgtgcgtggaggtccggta tcaggccact gacggcacag tgggctcctg ggacgatggg gacttcctgg gagatgagtctcttcaagag gaagagaagg acagccaaga gacggatgga ctgctcccag gctcccggcc cagctcccggcccccaggag agaagagctt ccggagagcc gggaggagcg tgttctccgc catgaagctc ggcaaaaaccggtctcacaa ggaggagccc caaagaccag atgaaccggc ggtgctggag atggaagacc ttgaccatctggccattcgg ctaggagatg gactggatcc cgactcggtg tctctagcct cagtcacagc tctcaccactaatgtctcca acaagcgatc taagccagac attaagatgg agccaagtgc tgggcggccc atggattaccaggtcagcat cacggtgatc gaggcccggc agctggtggg cttgaacatg gaccctgtgg tgtgcgtggaggtgggtgac gacaagaagt acacatccat gaaggagtcc actaactgcc cctattacaa cgagtacttcgtcttcgact tccatgtctc tccggatgtc atgtttgaca agatcatcaa gatttcggtgattcactccaagaacctgct gcgcagtggc accctggtgg gctccttcaa aatggacgtg ggaaccgtgtactcgcagcc agagcaccag ttccatcaca agtgggccat cctgtctgac cccgatgaca tctcctcggggctgaagggc tacgtgaagt gtgacgttgc cgtggtgggc aaaggggaca acatcaagac gccccacaaggccaatgaga ccgacgaaga tgacattgag gggaacttgc tgctccccga gggggtgccc cccgaacgccagtgggcccg gttctatgtg aaaatttacc gagcagaggg gctgccccgt atgaacacaa gcctcatggccaatgtaaag aaggctttca tcggtgaaaa caaggacctc gtggacccct acgtgcaagt cttctttgctggccagaagg gcaagacttc agtgcagaag agcagctatg agcccctgtg gaatgagcag gtcgtctttacagacctctt ccccccactc tgcaaacgca tgaaggtgca gatccgagac tcggacaagg tcaacgacgtggccatcggc acccacttca ttgacctgcg caagatttct aatgacggag acaaaggctt cctgcccacactgggcccag cctgggtgaa catgtacggc tccacacgta actacacgct gctggatgag catcaggacctgaacgaggg cctgggggag ggtgtgtcct tccgggcccg gctcctgctg ggcctggctg tggagatcgtagacacctcc aaccctgagc tcaccagctc cacagaggtg caggtggagc aggccacgcc catctcggagagctgtgcag gtaaaatgga agaattcttt ctctttggag ccttcctgga ggcctcaatg atcgaccggagaaacggaga caagcccatc acctttgagg tcaccatagg caactatggg aacgaagttg atggcctgtcccggccccag cggcctcggc cccggaagga gccgggggat gaggaagaag tagacctgat tcagaacgcaagtgatgacg aggccggtga tgccggggac ctggcctcag tctcctccac tccaccaatg cggccccaggtcaccgacag gaactacttc catctgccct acctggagcg aaagccctgc atctacatca agagctggtggccggaccag cgccgccgcc tctacaatgc caacatcatg gaccacattg ccgacaagct ggaagaaggcctgaacgaca tacaggagat gatcaaaacg gagaagtcct accctgagcg tcgcctgcgg ggcgtcctggaggagctgag ctgtggctgc tgccgcttcc tctccctcgc tgacaaggac cagggccact catcccgcaccaggcttgac cgggagcgcc tcaagtcctg catgagggag ctggaaaaca tggggcagca ggccaggatgctgcgggccc aggtgaagcg gcacacggtg cgggacaagc tgaggctgtg ccagaacttc ctgcagaagctgcgcttcct ggcggacgag ccccagcaca gcattcccga catcttcatc tggatgatga gcaacaacaagcgtgtcgcc tatgcccgtg tgccctccaa ggacctgctc ttctccatcg tggaggagga gactggcaaggactgcgcca aggtcaagac gctcttcctt aagctgccag ggaagcgggg cttcggctcg gcaggctggacagtgcaggc caaggtggag ctgtacctgt ggctgggcct cagcaaacag cgcaaggagt tcctgtgcggcctgccctgt ggcttccagg aggtcaaggc agcccagggc ctgggcctgc atgccttccc acccgtcagcctggtctaca ccaagaagca ggcgttccag ctccgagcgc acatgtacca ggcccgcagc ctctttgccgccgacagcag cggactctca gacccctttg cccgcgtctt cttcatcaat cagagtcagt gcacagaggtgctgaatgag accctgtgtc ccacctggga ccagatgctg gtgttcgaca acctggagct ctatggtgaagctcatgagc tgagggacga tccgcccatc attgtcattg aaatctatga ccaggattcc atgggcaaagctgacttcat gggccggacc ttcgccaaac ccctggtgaa gatggcagac gaggcgtact gcccaccccgcttcccacct cagctcgagt actaccagat ctaccgtggc aacgccacag ctggagacct gctggcggccttcgagctgc tgcagattgg accagcaggg aaggctgacc tgccccccat caatggcccg gtggacgtggaccgaggtcc catcatgccc gtgcccatgg gcatccggcc cgtgctcagc aagtaccgag tggaggtgctgttctggggc ctacgggacc taaagcgggt gaacctggcc caggtggacc ggccacgggt ggacatcgagtgtgcaggga agggggtgca gtcgtccctg atccacaatt ataagaagaa ccccaacttc aacaccctcgtcaagtggtt tgaagtggac ctcccagaga acgagctgct gcacccgccc ttgaacatcc gtgtggtggactgccgggcc ttcggtcgct acacactggt gggctcccat gccgtcagct ccctgcgacg cttcatctaccggcccccag accgctcggc ccccagctgg aacaccacgg tcaggcttct ccggcgctgc cgtgtgctgtgcaatggggg ctcctcctct cactccacag gggaggttgt ggtgactatg gagccagagg tacccatcaagaaactggag accatggtga agctggacgc gacttctgaa gctgttgtca aggtggatgt ggctgaggaggagaaggaga agaagaagaa gaagaagggc actgcggagg agccagagga ggaggagcca gacgagagcatgctggactg gtggtccaag tactttgcct ccattgacac catgaaggag caacttcgac aacaagagccctctggaatt gacttggagg agaaggagga agtggacaat accgagggcc tgaaggggtc aatgaagggcaaggagaagg caagggctgc caaagaggag aagaagaaga aaactcagag ctctggctct ggccaggggtccgaggcccc cgagaagaag aaacccaaga ttgatgagct taaggtatac cccaaagagc tggagtccgagtttgataac tttgaggact ggctgcacac tttcaacttg cttcggggca agaccgggga tgatgaggatggctccaccg aggaggagcg cattgtggga cgcttcaagg gctccctctg cgtgtacaaa gtgccactcccagaggacgt gtcccgggaa gccggctacg actccaccta cggcatgttc cagggcatcc cgagcaatgaccccatcaat gtgctggtcc gagtctatgt ggtccgggcc acggacctgc accctgctga catcaacggcaaagctgacc cctacatcgc catccggcta ggcaagactg acatccgcga caaggagaac tacatctccaagcagctcaa ccctgtcttt gggaagtcct ttgacatcga ggcctccttc cccatggaat ccatgctgacggtggctgtg tatgactggg acctggtggg cactgatgac ctcattgggg aaaccaagat cgacctggagaaccgcttct acagcaagca ccgcgccacc tgcggcatcg cccagaccta ctccacacat ggctacaatatctggcggga ccccatgaag cccagccaga tcctgacccg cctctgcaaa gacggcaaag tggacggcccccactttggg ccccctggga gagtgaaggt ggccaaccgc gtcttcactg ggccctctga gattgaggacgagaacggtc agaggaagcc cacagacgag catgtggcgc tgttggccct gaggcactgg gaggacatcccccgcgcagg ctgccgcctg gtgccagagc atgtggagac gaggccgctg ctcaaccccg acaagccgggcatcgagcag ggccgcctgg agctgtgggt ggacatgttc cccatggaca tgccagcccc tgggacgcctctggacatct cacctcggaa gcccaagaag tacgagctgc gggtcatcat ctggaacaca gatgaggtggtcttggagga cgacgacttc ttcacagggg agaagtccag tgacatcttc gtgagggggt ggctgaagggccagcaggag gacaagcagg acacagacgt ccactaccac tccctcactg gcgagggcaa cttcaactggcgctacctgt tccccttcga ctacctggcg gcggaggaga agatcgtcat ctccaagaag gagtccatgttctcctggga cgagaccgag tacaagatcc ccgcgcggct caccctgcag atctgggatg cggaccacttctccgctgac gacttcctgg gggccatcga gctggacctg aaccggttcc cgcggggcgc aaagacagccaagcagtgca ccatggagat ggccaccggg gaggtggacg tgcccctcgt gtccatcttc aagcaaaagcgcgtcaaagg ctggtggccc ctcctggccc gcaatgagaa cgatgagttt gagctcacgg gcaaggtggaggctgagctg catttactga cagcagagga ggcagagaag aacccagtgg gcctggcccg caatgaacctgaccccctag agaaacccaa ccggcccgac acgagcttca tctggttcct gaaccctctc aagtcggctcgctacttctt gtggcacacg tatcgctggc tgctcctcaa actgttgctg ctcctgctgc tgctcctcctcctcgccctg ttcctctact ctgtgcctgg ctacctggtc aagaaaatcc tcggggcctg a
人耳畸蛋白转录变体2(SEQ ID NO:15)(编码SEQ ID NO:11的蛋白质)
atgatcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggag gagctgagctgtggctgctg ccgcttcctc tccctcgctg acaaggacca gggccactca tcccgcacca ggcttgaccgggagcgcctc aagtcctgca tgagggagct ggaaaacatg gggcagcagg ccaggatgct gcgggcccaggtgaagcggc acacggtgcg ggacaagctg aggctgtgcc agaacttcct gcagaagctg cgcttcctggcggacgagcc ccagcacagc attcccgaca tcttcatctg gatgatgagc aacaacaagc gtgtcgcctatgcccgtgtg ccctccaagg acctgctctt ctccatcgtg gaggaggaga ctggcaagga ctgcgccaaggtcaagacgc tcttccttaa gctgccaggg aagcggggct tcggctcggc aggctggaca gtgcaggccaaggtggagct gtacctgtgg ctgggcctca gcaaacagcg caaggagttc ctgtgcggcc tgccctgtggcttccaggag gtcaaggcag cccagggcct gggcctgcat gccttcccac ccgtcagcct ggtctacaccaagaagcagg cgttccagct ccgagcgcac atgtaccagg cccgcagcct ctttgccgcc gacagcagcggactctcaga cccctttgcc cgcgtcttct tcatcaatca gagtcagtgc acagaggtgc tgaatgagaccctgtgtccc acctgggacc agatgctggt gttcgacaac ctggagctct atggtgaagc tcatgagctgagggacgatc cgcccatcat tgtcattgaa atctatgacc aggattccat gggcaaagct gacttcatgggccggacctt cgccaaaccc ctggtgaaga tggcagacga ggcgtactgc ccaccccgct tcccacctcagctcgagtac taccagatct accgtggcaa cgccacagct ggagacctgc tggcggcctt cgagctgctgcagattggac cagcagggaa ggctgacctg ccccccatca atggcccggt ggacgtggac cgaggtcccatcatgcccgt gcccatgggc atccggcccg tgctcagcaa gtaccgagtg gaggtgctgt tctggggcctacgggaccta aagcgggtga acctggccca ggtggaccgg ccacgggtgg acatcgagtg tgcagggaagggggtgcagt cgtccctgat ccacaattat aagaagaacc ccaacttcaa caccctcgtc aagtggtttgaagtggacct cccagagaac gagctgctgc acccgccctt gaacatccgt gtggtggact gccgggccttcggtcgctac acactggtgg gctcccatgc cgtcagctcc ctgcgacgct tcatctaccg gcccccagaccgctcggccc ccagctggaa caccacgggg gaggttgtgg tgactatgga gccagaggta cccatcaagaaactggagac catggtgaag ctggacgcga cttctgaagc tgttgtcaag gtggatgtgg ctgaggaggagaaggagaag aagaagaaga agaagggcac tgcggaggag ccagaggagg aggagccaga cgagagcatgctggactggt ggtccaagta ctttgcctcc attgacacca tgaaggagca acttcgacaa caagagccctctggaattga cttggaggag aaggaggaag tggacaatac cgagggcctg aaggggtcaa tgaagggcaaggagaaggca agggctgcca aagaggagaa gaagaagaaa actcagagct ctggctctgg ccaggggtccgaggcccccg agaagaagaa acccaagatt gatgagctta aggtataccc caaagagctg gagtccgagtttgataactt tgaggactgg ctgcacactt tcaacttgct tcggggcaag accggggatg atgaggatggctccaccgag gaggagcgca ttgtgggacg cttcaagggc tccctctgcg tgtacaaagt gccactcccagaggacgtgt cccgggaagc cggctacgac tccacctacg gcatgttcca gggcatcccg agcaatgaccccatcaatgt gctggtccga gtctatgtgg tccgggccac ggacctgcac cctgctgaca tcaacggcaaagctgacccc tacatcgcca tccggctagg caagactgac atccgcgaca aggagaacta catctccaagcagctcaacc ctgtctttgg gaagtccttt gacatcgagg cctccttccc catggaatcc atgctgacggtggctgtgta tgactgggac ctggtgggca ctgatgacct cattggggaa accaagatcg acctggagaaccgcttctac agcaagcacc gcgccacctg cggcatcgcc cagacctact ccacacatgg ctacaatatctggcgggacc ccatgaagcc cagccagatc ctgacccgcc tctgcaaaga cggcaaagtg gacggcccccactttgggcc ccctgggaga gtgaaggtgg ccaaccgcgt cttcactggg ccctctgaga ttgaggacgagaacggtcag aggaagccca cagacgagca tgtggcgctg ttggccctga ggcactggga ggacatcccccgcgcaggct gccgcctggt gccagagcat gtggagacga ggccgctgct caaccccgac aagccgggcatcgagcaggg ccgcctggag ctgtgggtgg acatgttccc catggacatg ccagcccctg ggacgcctctggacatctca cctcggaagc ccaagaagta cgagctgcgg gtcatcatct ggaacacaga tgaggtggtcttggaggacg acgacttctt cacaggggag aagtccagtg acatcttcgt gagggggtgg ctgaagggccagcaggagga caagcaggac acagacgtcc actaccactc cctcactggc gagggcaact tcaactggcgctacctgttc cccttcgact acctggcggc ggaggagaag atcgtcatct ccaagaagga gtccatgttctcctgggacg agaccgagta caagatcccc gcgcggctca ccctgcagat ctgggatgcg gaccacttctccgctgacga cttcctgggg gccatcgagc tggacctgaa ccggttcccg cggggcgcaa agacagccaagcagtgcacc atggagatgg ccaccgggga ggtggacgtg cccctcgtgt ccatcttcaa gcaaaagcgcgtcaaaggct ggtggcccct cctggcccgc aatgagaacg atgagtttga gctcacgggc aaggtggaggctgagctgca tttactgaca gcagaggagg cagagaagaa cccagtgggc ctggcccgca atgaacctgaccccctagag aaacccaacc ggcccgacac gagcttcatc tggttcctga accctctcaa gtcggctcgctacttcttgt ggcacacgta tcgctggctg ctcctcaaac tgttgctgct cctgctgctg ctcctcctcctcgccctgtt cctctactct gtgcctggct acctggtcaa gaaaatcctc ggggcctga
人耳畸蛋白转录变体3(SEQ ID NO:16)(编码SEQ ID NO:8的蛋白质)
atgatgaccga tactcaggat ggccctagcg agagctccca gatcatgagg tccctcactcccctgatcaa cagggaggag gcatttgggg aggctgggga ggcggggctg tggcccagca tcacccacactcctgattca caggaagaag gcctgaacga catacaggag atgatcaaaa cggagaagtc ctaccctgagcgtcgcctgc ggggcgtcct ggaggagctg agctgtggct gctgccgctt cctctccctc gctgacaaggaccagggcca ctcatcccgc accaggcttg accgggagcg cctcaagtcc tgcatgaggg agctggaaaacatggggcag caggccagga tgctgcgggc ccaggtgaag cggcacacgg tgcgggacaa gctgaggctgtgccagaact tcctgcagaa gctgcgcttc ctggcggacg agccccagca cagcattccc gacatcttcatctggatgat gagcaacaac aagcgtgtcg cctatgcccg tgtgccctcc aaggacctgc tcttctccatcgtggaggag gagactggca aggactgcgc caaggtcaag acgctcttcc ttaagctgcc agggaagcggggcttcggct cggcaggctg gacagtgcag gccaaggtgg agctgtacct gtggctgggc ctcagcaaacagcgcaagga gttcctgtgc ggcctgccct gtggcttcca ggaggtcaag gcagcccagg gcctgggcctgcatgccttc ccacccgtca gcctggtcta caccaagaag caggcgttcc agctccgagc gcacatgtaccaggcccgca gcctctttgc cgccgacagc agcggactct cagacccctt tgcccgcgtc ttcttcatcaatcagagtca gtgcacagag gtgctgaatg agaccctgtg tcccacctgg gaccagatgc tggtgttcgacaacctggag ctctatggtg aagctcatga gctgagggac gatccgccca tcattgtcat tgaaatctatgaccaggatt ccatgggcaa agctgacttc atgggccgga ccttcgccaa acccctggtg aagatggcagacgaggcgta ctgcccaccc cgcttcccac ctcagctcga gtactaccag atctaccgtg gcaacgccacagctggagac ctgctggcgg ccttcgagct gctgcagatt ggaccagcag ggaaggctga cctgccccccatcaatggcc cggtggacgt ggaccgaggt cccatcatgc ccgtgcccat gggcatccgg cccgtgctcagcaagtaccg agtggaggtg ctgttctggg gcctacggga cctaaagcgg gtgaacctgg cccaggtggaccggccacgg gtggacatcg agtgtgcagg gaagggggtg cagtcgtccc tgatccacaa ttataagaagaaccccaact tcaacaccct cgtcaagtgg tttgaagtgg acctcccaga gaacgagctg ctgcacccgcccttgaacat ccgtgtggtg gactgccggg ccttcggtcg ctacacactg gtgggctccc atgccgtcagctccctgcga cgcttcatct accggccccc agaccgctcg gcccccagct ggaacaccac ggtcaggcttctccggcgct gccgtgtgct gtgcaatggg ggctcctcct ctcactccac aggggaggtt gtggtgactatggagccaga ggtacccatc aagaaactgg agaccatggt gaagctggac gcgacttctg aagctgttgtcaaggtggat gtggctgagg aggagaagga gaagaagaag aagaagaagg gcactgcgga ggagccagaggaggaggagc cagacgagag catgctggac tggtggtcca agtactttgc ctccattgac accatgaaggagcaacttcg acaacaagag ccctctggaa ttgacttgga ggagaaggag gaagtggaca ataccgagggcctgaagggg tcaatgaagg gcaaggagaa ggcaagggct gccaaagagg agaagaagaa gaaaactcagagctctggct ctggccaggg gtccgaggcc cccgagaaga agaaacccaa gattgatgag cttaaggtataccccaaaga gctggagtcc gagtttgata actttgagga ctggctgcac actttcaact tgcttcggggcaagaccggg gatgatgagg atggctccac cgaggaggag cgcattgtgg gacgcttcaa gggctccctctgcgtgtaca aagtgccact cccagaggac gtgtcccggg aagccggcta cgactccacc tacggcatgttccagggcat cccgagcaat gaccccatca atgtgctggt ccgagtctat gtggtccggg ccacggacctgcaccctgct gacatcaacg gcaaagctga cccctacatc gccatccggc taggcaagac tgacatccgcgacaaggaga actacatctc caagcagctc aaccctgtct ttgggaagtc ctttgacatc gaggcctccttccccatgga atccatgctg acggtggctg tgtatgactg ggacctggtg ggcactgatg acctcattggggaaaccaag atcgacctgg agaaccgctt ctacagcaag caccgcgcca cctgcggcat cgcccagacctactccacac atggctacaa tatctggcgg gaccccatga agcccagcca gatcctgacc cgcctctgcaaagacggcaa agtggacggc ccccactttg ggccccctgg gagagtgaag gtggccaacc gcgtcttcactgggccctct gagattgagg acgagaacgg tcagaggaag cccacagacg agcatgtggc gctgttggccctgaggcact gggaggacat cccccgcgca ggctgccgcc tggtgccaga gcatgtggag acgaggccgctgctcaaccc cgacaagccg ggcatcgagc agggccgcct ggagctgtgg gtggacatgt tccccatggacatgccagcc cctgggacgc ctctggacat ctcacctcgg aagcccaaga agtacgagct gcgggtcatcatctggaaca cagatgaggt ggtcttggag gacgacgact tcttcacagg ggagaagtcc agtgacatcttcgtgagggg gtggctgaag ggccagcagg aggacaagca ggacacagac gtccactacc actccctcactggcgagggc aacttcaact ggcgctacct gttccccttc gactacctgg cggcggagga gaagatcgtcatctccaaga aggagtccat gttctcctgg gacgagaccg agtacaagat ccccgcgcgg ctcaccctgcagatctggga tgcggaccac ttctccgctg acgacttcct gggggccatc gagctggacc tgaaccggttcccgcggggc gcaaagacag ccaagcagtg caccatggag atggccaccg gggaggtgga cgtgcccctcgtgtccatct tcaagcaaaa gcgcgtcaaa ggctggtggc ccctcctggc ccgcaatgag aacgatgagtttgagctcac gggcaaggtg gaggctgagc tgcatttact gacagcagag gaggcagaga agaacccagtgggcctggcc cgcaatgaac ctgaccccct agagaaaccc aaccggcccg acacgagctt catctggttcctgaaccctc tcaagtcggc tcgctacttc ttgtggcaca cgtatcgctg gctgctcctc aaactgttgctgctcctgct gctgctcctc ctcctcgccc tgttcctcta ctctgtgcct ggctacctgg tcaagaaaatcctcggggcc tga
人耳畸蛋白转录变体4(SEQ ID NO:17)(编码SEQ ID NO:9的蛋白质)
atga tcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggaggagctgagct gtggctgctg ccgcttcctc tccctcgctg acaaggacca gggccactca tcccgcaccaggcttgaccg ggagcgcctc aagtcctgca tgagggagct ggaaaacatg gggcagcagg ccaggatgctgcgggcccag gtgaagcggc acacggtgcg ggacaagctg aggctgtgcc agaacttcct gcagaagctgcgcttcctgg cggacgagcc ccagcacagc attcccgaca tcttcatctg gatgatgagc aacaacaagcgtgtcgccta tgcccgtgtg ccctccaagg acctgctctt ctccatcgtg gaggaggaga ctggcaaggactgcgccaag gtcaagacgc tcttccttaa gctgccaggg aagcggggct tcggctcggc aggctggacagtgcaggcca aggtggagct gtacctgtgg ctgggcctca gcaaacagcg caaggagttc ctgtgcggcctgccctgtgg cttccaggag gtcaaggcag cccagggcct gggcctgcat gccttcccac ccgtcagcctggtctacacc aagaagcagg cgttccagct ccgagcgcac atgtaccagg cccgcagcct ctttgccgccgacagcagcg gactctcaga cccctttgcc cgcgtcttct tcatcaatca gagtcagtgc acagaggtgctgaatgagac cctgtgtccc acctgggacc agatgctggt gttcgacaac ctggagctct atggtgaagctcatgagctg agggacgatc cgcccatcat tgtcattgaa atctatgacc aggattccat gggcaaagctgacttcatgg gccggacctt cgccaaaccc ctggtgaaga tggcagacga ggcgtactgc ccaccccgcttcccacctca gctcgagtac taccagatct accgtggcaa cgccacagct ggagacctgc tggcggccttcgagctgctg cagattggac cagcagggaa ggctgacctg ccccccatca atggcccggt ggacgtggaccgaggtccca tcatgcccgt gcccatgggc atccggcccg tgctcagcaa gtaccgagtg gaggtgctgttctggggcct acgggaccta aagcgggtga acctggccca ggtggaccgg ccacgggtgg acatcgagtgtgcagggaag ggggtgcagt cgtccctgat ccacaattat aagaagaacc ccaacttcaa caccctcgtcaagtggtttgaagtggacct cccagagaac gagctgctgc acccgccctt gaacatccgt gtggtggactgccgggcctt cggtcgctac acactggtgg gctcccatgc cgtcagctcc ctgcgacgct tcatctaccggcccccagac cgctcggccc ccagctggaa caccacgggg gaggttgtgg tgactatgga gccagaggtacccatcaaga aactggagac catggtgaag ctggacgcga cttctgaagc tgttgtcaag gtggatgtggctgaggagga gaaggagaag aagaagaaga agaagggcac tgcggaggag ccagaggagg aggagccagacgagagcatg ctggactggt ggtccaagta ctttgcctcc attgacacca tgaaggagca acttcgacaacaagagccct ctggaattga cttggaggag aaggaggaag tggacaatac cgagggcctg aaggggtcaatgaagggcaa ggagaaggca agggctgcca aagaggagaa gaagaagaaa actcagagct ctggctctggccaggggtcc gaggcccccg agaagaagaa acccaagatt gatgagctta aggtataccc caaagagctggagtccgagt ttgataactt tgaggactgg ctgcacactt tcaacttgct tcggggcaag accggggatgatgaggatgg ctccaccgag gaggagcgca ttgtgggacg cttcaagggc tccctctgcg tgtacaaagtgccactccca gaggacgtgt cccgggaagc cggctacgac tccacctacg gcatgttcca gggcatcccgagcaatgacc ccatcaatgt gctggtccga gtctatgtgg tccgggccac ggacctgcac cctgctgacatcaacggcaa agctgacccc tacatcgcca tccggctagg caagactgac atccgcgaca aggagaactacatctccaag cagctcaacc ctgtctttgg gaagtccttt gacatcgagg cctccttccc catggaatccatgctgacgg tggctgtgta tgactgggac ctggtgggca ctgatgacct cattggggaa accaagatcgacctggagaa ccgcttctac agcaagcacc gcgccacctg cggcatcgcc cagacctact ccacacatggctacaatatc tggcgggacc ccatgaagcc cagccagatc ctgacccgcc tctgcaaaga cggcaaagtggacggccccc actttgggcc ccctgggaga gtgaaggtgg ccaaccgcgt cttcactggg ccctctgagattgaggacga gaacggtcag aggaagccca cagacgagca tgtggcgctg ttggccctga ggcactgggaggacatcccc cgcgcaggct gccgcctggt gccagagcat gtggagacga ggccgctgct caaccccgacaagccgggca tcgagcaggg ccgcctggag ctgtgggtgg acatgttccc catggacatg ccagcccctgggacgcctct ggacatctca cctcggaagc ccaagaagta cgagctgcgg gtcatcatct ggaacacagatgaggtggtc ttggaggacg acgacttctt cacaggggag aagtccagtg acatcttcgt gagggggtggctgaagggcc agcaggagga caagcaggac acagacgtcc actaccactc cctcactggc gagggcaacttcaactggcg ctacctgttc cccttcgact acctggcggc ggaggagaag atcgtcatct ccaagaaggacctggcccgc aatgagaacg atgagtttga gctcacgggc aaggtggagg ctgagctgca tttactgacagcagaggagg cagagaagaa cccagtgggc ctggcccgca atgaacctga ccccctagag aaacccaaccggcccgacac ggccttcgtc tggttcctca accctctcaa gtccatcaag tacctcatct gcacccggtacaagtggctc atcatcaaga tcgtgctggc gctgttgggg ctgctcatgt tggggctctt cctctacagcctccctggct acatggtcaa aaagctcctt ggggcatga
人耳畸蛋白转录变体5(SEQ ID NO:18)(编码SEQ ID NO:12的蛋白质)
atg gccttgctca tccacctcaa gacagtctcg gagctgcggg gcaggggcga ccggatcgccaaagtgactt tccgagggca atccttctac tctcgggtcc tggagaactg tgaggatgtg gctgactttgatgagacatt tcggtggccg gtggccagca gcatcgacag aaatgagatg ctggagattc aggttttcaactacagcaaa gtcttcagca acaagctcat cgggaccttc cgcatggtgc tgcagaaggt ggtagaggagagccatgtgg aggtgactga cacgctgatt gatgacaaca atgctatcat caagaccagc ctgtgcgtggaggtccggta tcaggccact gacggcacag tgggctcctg ggacgatggg gacttcctgg gagatgagtctcttcaagag gaagagaagg acagccaaga gacggatgga ctgctcccag gctcccggcc cagctcccggcccccaggag agaagagctt ccggagagcc gggaggagcg tgttctccgc catgaagctc ggcaaaaaccggtctcacaa ggaggagccc caaagaccag atgaaccggc ggtgctggag atggaagacc ttgaccatctggccattcgg ctaggagatg gactggatcc cgactcggtg tctctagcct cagtcacagc tctcaccactaatgtctcca acaagcgatc taagccagac attaagatgg agccaagtgc tgggcggccc atggattaccaggtcagcat cacggtgatc gaggcccggc agctggtggg cttgaacatg gaccctgtgg tgtgcgtggaggtgggtgac gacaagaagt acacatccat gaaggagtcc actaactgcc cctattacaa cgagtacttcgtcttcgact tccatgtctc tccggatgtc atgtttgaca agatcatcaa gatttcggtg attcactccaagaacctgct gcgcagtggc accctggtgg gctccttcaa aatggacgtg ggaaccgtgt actcgcagccagagcaccag ttccatcaca agtgggccat cctgtctgac cccgatgaca tctcctcggg gctgaagggctacgtgaagt gtgacgttgc cgtggtgggc aaaggggaca acatcaagac gccccacaag gccaatgagaccgacgaaga tgacattgag gggaacttgc tgctccccga gggggtgccc cccgaacgcc agtgggcccggttctatgtg aaaatttacc gagcagaggg gctgccccgt atgaacacaa gcctcatggc caatgtaaagaaggctttca tcggtgaaaa caaggacctc gtggacccct acgtgcaagt cttctttgct ggccagaagggcaagacttc agtgcagaag agcagctatg agcccctgtg gaatgagcag gtcgtcttta cagacctcttccccccactc tgcaaacgca tgaaggtgca gatccgagac tcggacaagg tcaacgacgt ggccatcggcacccacttca ttgacctgcg caagatttct aatgacggag acaaaggctt cctgcccaca ctgggcccagcctgggtgaa catgtacggc tccacacgta actacacgct gctggatgag catcaggacc tgaacgagggcctgggggag ggtgtgtcct tccgggcccg gctcctgctg ggcctggctg tggagatcgt agacacctccaaccctgagc tcaccagctc cacagaggtg caggtggagc aggccacgcc catctcggag agctgtgcaggtaaaatgga agaattcttt ctctttggag ccttcctgga ggcctcaatg atcgaccgga gaaacggagacaagcccatc acctttgagg tcaccatagg caactatggg aacgaagttg atggcctgtc ccggccccagcggcctcggc cccggaagga gccgggggat gaggaagaag tagacctgat tcagaacgca agtgatgacgaggccggtga tgccggggac ctggcctcag tctcctccac tccaccaatg cggccccagg tcaccgacaggaactacttc catctgccct acctggagcg aaagccctgc atctacatca agagctggtg gccggaccagcgccgccgcc tctacaatgc caacatcatg gaccacattg ccgacaagct ggaagaaggc ctgaacgacatacaggagat gatcaaaacg gagaagtcct accctgagcg tcgcctgcgg ggcgtcctgg aggagctgagctgtggctgc tgccgcttcc tctccctcgc tgacaaggac cagggccact catcccgcac caggcttgaccgggagcgcc tcaagtcctg catgagggag ctggaaaaca tggggcagca ggccaggatg ctgcgggcccaggtgaagcg gcacacggtg cgggacaagc tgaggctgtg ccagaacttc ctgcagaagc tgcgcttcctggcggacgag ccccagcaca gcattcccga catcttcatc tggatgatga gcaacaacaa gcgtgtcgcctatgcccgtg tgccctccaa ggacctgctc ttctccatcg tggaggagga gactggcaag gactgcgccaaggtcaagac gctcttcctt aagctgccag ggaagcgggg cttcggctcg gcaggctgga cagtgcaggccaaggtggag ctgtacctgt ggctgggcct cagcaaacag cgcaaggagt tcctgtgcgg cctgccctgtggcttccagg aggtcaaggc agcccagggc ctgggcctgc atgccttccc acccgtcagc ctggtctacaccaagaagca ggcgttccag ctccgagcgc acatgtacca ggcccgcagc ctctttgccg ccgacagcagcggactctca gacccctttg cccgcgtctt cttcatcaat cagagtcagt gcacagaggt gctgaatgagaccctgtgtc ccacctggga ccagatgctg gtgttcgaca acctggagct ctatggtgaa gctcatgagctgagggacga tccgcccatc attgtcattg aaatctatga ccaggattcc atgggcaaag ctgacttcatgggccggacc ttcgccaaac ccctggtgaa gatggcagac gaggcgtact gcccaccccg cttcccacctcagctcgagt actaccagat ctaccgtggc aacgccacag ctggagacct gctggcggcc ttcgagctgctgcagattgg accagcaggg aaggctgacc tgccccccat caatggcccg gtggacgtgg accgaggtcccatcatgccc gtgcccatgg gcatccggcc cgtgctcagc aagtaccgag tggaggtgct gttctggggcctacgggacc taaagcgggt gaacctggcc caggtggacc ggccacgggt ggacatcgag tgtgcagggaagggggtgca gtcgtccctg atccacaatt ataagaagaa ccccaacttc aacaccctcg tcaagtggtttgaagtggac ctcccagaga acgagctgct gcacccgccc ttgaacatcc gtgtggtgga ctgccgggccttcggtcgct acacactggt gggctcccat gccgtcagct ccctgcgacg cttcatctac cggcccccagaccgctcggc ccccagctgg aacaccacgg tcaggcttct ccggcgctgc cgtgtgctgt gcaatgggggctcctcctct cactccacag gggaggttgt ggtgactatg gagccagagg tacccatcaa gaaactggagaccatggtga agctggacgc gacttctgaa gctgttgtca aggtggatgt ggctgaggag gagaaggagaagaagaagaa gaagaagggc actgcggagg agccagagga ggaggagcca gacgagagca tgctggactggtggtccaag tactttgcct ccattgacac catgaaggag caacttcgac aacaagagcc ctctggaattgacttggagg agaaggagga agtggacaat accgagggcc tgaaggggtc aatgaagggc aaggagaaggcaagggctgc caaagaggag aagaagaaga aaactcagag ctctggctct ggccaggggt ccgaggcccccgagaagaag aaacccaaga ttgatgagct taaggtatac cccaaagagc tggagtccga gtttgataactttgaggact ggctgcacac tttcaacttg cttcggggca agaccgggga tgatgaggat ggctccaccgaggaggagcg cattgtggga cgcttcaagg gctccctctg cgtgtacaaa gtgccactcc cagaggacgtgtcccgggaa gccggctacg actccaccta cggcatgttc cagggcatcc cgagcaatga ccccatcaatgtgctggtcc gagtctatgt ggtccgggcc acggacctgc accctgctga catcaacggc aaagctgacccctacatcgc catccggcta ggcaagactg acatccgcga caaggagaac tacatctcca agcagctcaaccctgtcttt gggaagtcct ttgacatcga ggcctccttc cccatggaat ccatgctgac ggtggctgtgtatgactggg acctggtggg cactgatgac ctcattgggg aaaccaagat cgacctggag aaccgcttctacagcaagca ccgcgccacc tgcggcatcg cccagaccta ctccacacat ggctacaata tctggcgggaccccatgaag cccagccaga tcctgacccg cctctgcaaa gacggcaaag tggacggccc ccactttgggccccctggga gagtgaaggt ggccaaccgc gtcttcactg ggccctctga gattgaggac gagaacggtcagaggaagcc cacagacgag catgtggcgc tgttggccct gaggcactgg gaggacatcc cccgcgcaggctgccgcctg gtgccagagc atgtggagac gaggccgctg ctcaaccccg acaagccggg catcgagcagggccgcctgg agctgtgggt ggacatgttc cccatggaca tgccagcccc tgggacgcct ctggacatctcacctcggaa gcccaagaag tacgagctgc gggtcatcat ctggaacaca gatgaggtgg tcttggaggacgacgacttc ttcacagggg agaagtccag tgacatcttc gtgagggggt ggctgaaggg ccagcaggaggacaagcagg acacagacgt ccactaccac tccctcactg gcgagggcaa cttcaactgg cgctacctgttccccttcga ctacctggcg gcggaggaga agatcgtcat ctccaagaag gagtccatgt tctcctgggacgagaccgag tacaagatcc ccgcgcggct caccctgcag atctgggatg cggaccactt ctccgctgacgacttcctgg gggccatcga gctggacctg aaccggttcc cgcggggcgc aaagacagcc aagcagtgcaccatggagat ggccaccggg gaggtggacg tgcccctcgt gtccatcttc aagcaaaagc gcgtcaaaggctggtggccc ctcctggccc gcaatgagaa cgatgagttt gagctcacgg gcaaggtgga ggctgagctgcatttactga cagcagagga ggcagagaag aacccagtgg gcctggcccg caatgaacct gaccccctagagaaacccaa ccggcccgac acggccttcg tctggttcct caaccctctc aagtccatca agtacctcatctgcacccgg tacaagtggc tcatcatcaa gatcgtgctg gcgctgttgg ggctgctcat gttggggctcttcctctaca gcctccctgg ctacatggtc aaaaagctcc ttggggcatg a
人野生型硬纤毛蛋白基因组DNA序列的非限制性实例是SEQ ID NO:19。SEQ IDNO:19中的外显子是：核苷酸位置5001-5206(外显子1)、核苷酸位置25925-25983(外显子2)、核苷酸位置35779-35867(外显子3)、核苷酸位置44590-44689(外显子4)、核苷酸位置47100-47281(外显子5)、核苷酸位置59854-59927(外显子6)、核苷酸位置61273-61399(外显子7)、核苷酸位置61891-61945(外显子8)、核苷酸位置68626-68757(外显子9)、核苷酸位置73959-74021(外显子10)、核苷酸位置74404-74488(外显子11)、核苷酸位置79066-79225(外显子12)、核苷酸位置80051-80237(外显子13)、核苷酸位置81107-81293(外显子14)、核苷酸位置82690-82913(外显子15)、核苷酸位置83388-83496(外显子16)、核苷酸位置84046-84226(外显子17)、核苷酸位置84315-84435(外显子18)、核苷酸位置85950-86050(外显子19)、核苷酸位置86193-86283(外显子20)、核苷酸位置86411-86527(外显子21)、核苷酸位置86656-86808(外显子22)、核苷酸位置87382-87571(外显子23)、核苷酸位置87661-87785(外显子24)、核苷酸位置88206-88340(外显子25)、核苷酸位置89025-89186(外显子26)、核苷酸位置89589-89708(外显子27)、核苷酸位置90132-90293(外显子28)、核苷酸位置90405-90567(外显子29)、核苷酸位置91050-91180(外显子30)、核苷酸位置92549-92578(外显子31)、核苷酸位置92978-93106(外显子32)、核苷酸位置95225-95291(外显子33)、核苷酸位置96198-96334(外显子34)、核苷酸位置96466-96600(外显子35)、核苷酸位置96848-96985(外显子36)、核苷酸位置97623-97750(外显子37)、核苷酸位置97857-98027(外显子38)、核苷酸位置98670-98830(外显子39)、核苷酸位置99593-99735(外显子40)、核苷酸位置100128-100216(外显子41)、核苷酸位置101518-101616(外显子42)、核苷酸位置101762-102003(外显子43)、核苷酸位置102669-102847(外显子44)、核苷酸位置102952-103052(外显子45)、核苷酸位置103494-103691(外显子46)、核苷酸位置105479-106496(外显子47)和外显子48(以CCGGCCCGAC起始的序列(SEQ ID NO:89)；另请参见Yasunaga等人，Am.J.Hum.Genet.67:591-600,2000中对该外显子的描述)。
内含子位于SEQ ID NO:19中每个相邻的外显子对之间，即，处于核苷酸位置100-5001(内含子1)、核苷酸5207-25924(内含子2)、核苷酸位置25984-35778(内含子3)、核苷酸位置35868-44589(内含子4)、核苷酸位置44690-47099(内含子5)、核苷酸位置47282-59853(内含子6)、核苷酸位置59928-61272(内含子7)、核苷酸位置61400-61890(内含子8)、核苷酸位置61946-68625(内含子9)、核苷酸位置68758-73958(内含子10)、核苷酸位置74022-74403(内含子11)、核苷酸位置74489-79065(内含子12)、核苷酸位置79226-80050(内含子13)、核苷酸位置80238-81106(内含子14)、核苷酸位置81294-82689(内含子15)、核苷酸位置82914-83387(内含子16)、核苷酸位置83497-84045(内含子17)、核苷酸位置84227-84314(内含子18)、核苷酸位置84436-85949(内含子19)、核苷酸位置86051-86192(内含子20)、核苷酸位置86284-86410(内含子21)、核苷酸位置86528-86655(内含子22)、核苷酸位置86809-87381(内含子23)、核苷酸位置87572-87660(内含子24)、核苷酸位置87786-88205(内含子25)、核苷酸位置88341-89024(内含子26)、核苷酸位置89187-89588(内含子27)、核苷酸位置89709-90131(内含子28)、核苷酸位置90294-90404(内含子29)、核苷酸位置90568-91049(内含子30)、核苷酸位置91181-92548(内含子31)、核苷酸位置92579-92977(内含子32)、核苷酸位置93107-95224(内含子33)、核苷酸位置95292-96197(内含子34)、核苷酸位置96335-96465(内含子35)、核苷酸位置96601-96847(内含子36)、核苷酸位置96986-97622(内含子37)、核苷酸位置97751-97856(内含子38)、核苷酸位置98028-98669(内含子39)、核苷酸位置98831-99592(内含子40)、核苷酸位置99736-100127(内含子41)、核苷酸位置100217-101517(内含子42)、核苷酸位置101617-101761(内含子43)、核苷酸位置102004-102668(内含子44)、核苷酸位置102848-102951(内含子45)、核苷酸位置103053-103494(内含子46)、核苷酸位置103692-105478(内含子47)和核苷酸位置106497-108496(内含子48)。
人耳畸蛋白基因序列(SEQ ID NO:19)(NCBI登录号NG_009937.1)
1 gggagagcat gcgggctttt tcacccattt ggagactctg cctgcagaat cctcaagaca
61 ttcatttcat tcattcgttc actctttttt tcagacaagg gttcttagga tcattcattc
121 attctataca gatttgctga tactgtacag gttgcctctc agaatccagt gcctgttctc
181 agtacctatg ctgactggta ggagggataa agacagcctt acaccctggg agaggcggtc
241 cagagtagaa acatcagaca ctgtaggaga aagagccaaa gaacaggagg caacagccag
301 acttgcatgt tagatggttg gagtctgaaa atatccagag taaagaaagg taggtgtaac
361 ctagtatttg aaagtgctaa acagcaagcc agcgctcagg gcaagtggcc aggaagcttt
421 ccaagaaaaa cttctgggag gataaaggga ggtctgtgaa aggaccgacc gcaaagtcgg
481 gcgggtactg cacacatgac ccattaacta cggctcttcc ggccttgcca ggttcttcga
541 gcgggcaccc acccggtatc cttccctcct tcaaccaaca agtactgacc ttgcccgaat
601 gctgggtgct ggccctgtgc gccggacgga agggcctgat tttctcgcat tttctctaag
661 cgctggaggc tgcccgcctg gggcgtctcc aagcactaaa ccccacgtgg ctccatctcc
721 tcccccttcc ccggctacat ccatgcgagg tcccttatgc cctgctggct gtgccccact
781 tgccagggag cgccttcctg tgaaggggaa tctggggagg cccccgcccg tgcctgccca
841 cttcctactc tgaaaccaca aacctctagg aaggcccctc gccccgtcgg gtggaaaatt
901 ggctcctcgg ggttccttca accccaaagt ccgggggcag ggggctgaat ttcgatcacc
961 gaggagggcg ctagtggaag ggggagggga ggaggcgctc cctcggcctt acccgggcat
1021 gagtccaggg ggcacgtagg cggcattgaa ctcggtcagt agggtgcccgcgctgcggga
1081 ggccatggtg ggtgcgcgag tacagcgagc ctggcgctcc gctccgccccacggtaaaca
1141 gcggcgggtc acctggcaac ggccacggcg gcgagcctgg caacgccagctggccccgcg
1201 gtcctcgcgt tccgagacac tgcgcccccc tggcggccac ctcccggagcagccccatag
1261 ggcgcgccca gaaggcgcct cccatttccg cgagctctgc tgggtgacccctgtcacttg
1321 ccccggcgcg tcggggctct ctgccttgct gcctgcggga tgtgcagaggctcagatgcg
1381 ggagggaggc agaacatcgc tggagaggcc tggcgggatc cgtcttgcggtgacccggct
1441 tggaacgcga cgctaccaca aaggacaggc caggtcctga ctttggaggtcacgcacgaa
1501 gcagctgccc caccgtggct caggcccaga aacctgagtg gccttagggtccccaggagc
1561 tatgtctctc caaggcttcc cctgcacccc agctccatgg gagttccaggaaggggctct
1621 gtagtgggcc gcgctgggcg aggttgccta ggacgctgtg tgtaattgtgtgtgtgcgtg
1681 cgtgcgtgca tgtgtgcgtg tgtgtgtgcg cgccttgcga agaggagcatttttcatttt
1741 tcttcttaat ctctagctga tggcttcctt ctcacctcat catacctgtaaactactcca
1801 caagaggcaa aaagaaaatc atagaacgtc tgggtgtgtg atttacatttgtccccaatg
1861 ctgccgttca ttttggggat ggcatccgca ggggtagcgc ttgccccagagagcaggcct
1921 gctgaaggcc caccccctgt gtaatcctcc ctgtgactgc ttcagcctccacatttgagt
1981 ttctccaggg acccttacac cagccttggt gcctagggca ggcacagggccttcggcttt
2041 tccataaggg gtgagggtat ggggacagct tccacggtgc caggctcttggtgactcggg
2101 tggaggccct gccaccccag ctccctctgc agcagtcctg gtgtcatgaagaagcctggc
2161 agttcccact ttgtctccag gtcttgcttc ttcccttcag atgccggatggagagcagtg
2221 ctcccctcgc acttcggttc tgtaaatggc agtggatgaa gaccgcagacgctactgggt
2281 tcacagaatg tggctgccac cagcattctc caaagacttc ccctggcaaatgccaatgaa
2341 atgaagggga gccacaggct tcccagaggc tcaggaagca gaaacactgaggcctggttg
2401 gaaagagagc tgtaggcaaa ggaacggctg caaacaaact gggtggaaggaaaatccatc
2461 catccttcag aatgcagtca tgtctgtatt tttctaaatt ctcattggggaacatgttct
2521 acaataagga aaacatgagt caaagacccc cagccctggt gaggttgaccgcctacttcc
2581 tcccccattc agggctgccc agccagtcct gctggtaaac ccaccaccctgccttccacc
2641 tgcctgtgtt ctagtccatc tgtctcgtct gattgggatc ctgtgccatccatatcatat
2701 tcatccctga atctcagcac ctggctctgg aaagaattca gtaaatgttcattacataaa
2761 ttatatactc agttaccaaa atgggtaaca gaagaatgga aattaaaaagtgggttctgg
2821 ctgggaacgg tggctcatgc ctgtaatccc agcattttgg aaggccgaggcaggcggatc
2881 acttgaggtc agcagtttga gaccagccta gccaacatgg tgaaaccccatctctactaa
2941 aaatacaaac attagctggg catggtagca catgcttata gtctgacctatttgggaggc
3001 tgaggcagga gaatcgcttg aacccgggag gcagaggttg cagtgagcctagatcactcc
3061 actgccctcc agcctgggtg acagagtgag actctctctc aaaaaaaaaaaaaaaaaaag
3121 agtgggatct gtctcttagg ttttcagaaa ggccagctga ctccattgagagctgctgag
3181 tggaattgct accattttat ggatgtggaa agtgagattc agcatagatcaatgccttgg
3241 ctagggcagg atcatgggct ttttcctaaa gatgcacagg gtctataagaggcctcatga
3301 aattcactcc tttcagggga ggacctccag agaaccaagg aagaagatattttctgttgt
3361 tgttgttgta ccttgtagtc accaagcctt aaaaacacag atcacctgatgacctcatgg
3421 atggaaaatg ctagtgaatt taggtgtttt tttttttaag acattaaacttatctagctt
3481 ttgaaaattt agcattcata cttgtattca ataaacagaa tactctaagacatttttaaa
3541 ttcaatatga ttagataaat gtgagaaagg taagcaagaa ttggttaggaaaaagtgcaa
3601 aggaaaaaaa cgtaagtaga aaaagaaaaa tagggcacag tagcaaggaaatatctagaa
3661 ggaggaaaga aggctcttgg gacatactgt aggttatttg gaatgcagaattcaaaagaa
3721 gtaacctctt gttaccatgc tgtgaaaaat tagtatttct ctttttaacctttagactct
3781 gtttcaggta gatccctgag ctcactcttt tatcctttca acagtaattgggcatcctac
3841 ggtgcacagg ataccatgtg gggctctggg gtagagggat gctgtgctccagggccctcc
3901 tgaggtcagg aggggaaaag gcaagggaag cagccccagg actcagtaagatgagaggag
3961 gcaggagcag cacagaggag gaccccaacc cagctggggt gcgggtacagaggcacctcc
4021 aggagcaggc actcaagctg agtccagggt ggggtggagg gcattccaccaagaatgaat
4081 agcaagaaca aggctgcaga tgaccctgca cagattccag catcagggattctggccccc
4141 agcgtccctt tccttggtgt atgctgctgg aagacaggag ggggcagttctcttttggtc
4201 cttagaaatt tccctataga catcccttct cctgccccta gcagcttataacagcagaag
4261 gccattcaat tctgctcctc tggctggaaa gcaaacatca gcctggcttaccttcgctag
4321 cctgcctgac ccccagcctt ggggtggggc taggttagtg ccctggatccttaaacatgg
4381 cccctggtag cacataagcc tctgctgcct ccacaaccag ccatctccatcatgcatggc
4441 ctggtcctga gcctcccctc aggcagcagc cccagcctct ctgcttcctgagattcagaa
4501 acagggatcc cagggcaggg ctcagggccc agcctcttgg gggcacagtctccagcaggg
4561 aagaggtggg cgtaggtgga caaatacatt cccttcttct tgtagtgtgcccctgtgggt
4621 gggagtgccc cccgccccac atccacccta cctatgctca tgcccactcctctgtgccca
4681 ctactggtgg cagggcttgc ttagcaggga agcagcagag ccctgcagaggggtgggcag
4741 agcctccctt ccaggagctg ggagaagaca cctgaagctg gacagagctttatctgggag
4801 ccggcggctg ctgaataatg aattccaact ctgccgcact cccaggctgcacattgggtg
4861 cacacacaca cacacacaca cgcacacacc gatacacaca cgctgggctgacaacttgga
4921 ggggcggggg ctgtgaggct ctgtgagtcg ctgcaggagc agcttagctcggcttggttg
4981 ccttggtctc tgtgggcagc atcggagggg ggtcgggagg aggaggaggaggcagcggca
5041 gagaagagag aggcgtgtga gccgtgctcc accggctagc tccttcccgctgctcctgcc
5101 tggcagtgcc aggcagccca caccagcatg gccttgctca tccacctcaagacagtctcg
5161 gagctgcggg gcaggggcga ccggatcgcc aaagtgactt tccgaggtagggaagccgct
5221 gtctcagagg gacgccagct ctgagagctg gaccagccca tgctctggaggtggccgggg
5281 ataggacagg gctgggagga tgggtgggaa aagttctagc aggggctggggcgacgagcc
5341 ttttcacagg tagtcatctg cctgggactg actggccatt gtgatttctggaaaatcagg
5401 gtcccctgtt cttccatgcc tgtgtctcct tgtgcttgcc aacatgccagttccccgggc
5461 agggcacaga gccctctgcc tggggaggca gaagtgagga ccacatccctgagctcaggg
5521 agacccagga ccccctcctt ctctctctct ccctctcctg caggttgatttccttgagca
5581 cagggtgggg gccgggtatg gagcctgggg cacccagggt gactgggagaaaccaggcag
5641 ccagtagctc cctgggcccc agagtgatgg gggacactgt tggcttcttttagatctatt
5701 catgggcggg aaccccggga gcccctcgcc tctcttctgt ctggtcttttctcatccttt
5761 tcactcctgt attcagcgac catttattat gatctactgt gtcccaaggataggggtaga
5821 aacacagagc tgagcacaac ccagccccag ccccaaggag cctgcatctgttgggcaggc
5881 gtggaacaag caggacaggt atgtgagaca gaaggtgggg gtgcagcatgcaagctacag
5941 aagcagcacc ctcacccagg ctggtgaccg gtggtcaggg aaggcttcccggaggaagta
6001 acactcagct aatacccgaa ggaccagcgg gtgggagcta ggagaggaggtaaggactga
6061 ggaggcagag gaaacagtgt gcccagagct gagagaggag ctgaaactctggaactgaaa
6121 gaggttccat gtgtctacag ctcagagagg gtgcaggagc ggaggccagagagccaagca
6181 gggcaaggag gcgaggctgg acctgacccc ggggacagcg gagcccctgagcattttaag
6241 tggggaaagg cagggccagg ctgactctgt ccttcaccac ccacctctgcctctccatgt
6301 ggttgctgcc cagccctgag ggttgggggt acttctcact agacatggccccttctcccg
6361 agagaggggt ctgagagtgg gatggggacg aggtggtgag aagggggcagagaggacccc
6421 cctatactaa agagcaaagt gagccttggg gcccaggctg gacacagtgtctgcacctct
6481 gttggaaggg atgggagaga ccattggcag aacattccag caagagccctggggcaccca
6541 catcacctac ccagaggccc tgggatgccc acattgcagc ttgtgttcatagggacaggc
6601 aggggtggag gtgatggcag tggccctgcc ggcaggcgga ggttaggcaggagggagagg
6661 gaggtgtggg ctgggctgcc ttttgcctcc caccccaacc cactgactgctttctctgca
6721 gcaccctgga tctccctctg tgtgccacct gcaggctcat gctggctttagaaaaagcaa
6781 atgtgtcctt tcatctgtga aatgtggccc tgagctccac gggcagcatagtgtggggcg
6841 gttaagctac aggttgccat cctgctgcag ctgtgctgga acggtccaggctgcaccgga
6901 caggcccact tgcaggccga gaaaccaagg ttcaggggta gaacactgcgcgtggcattc
6961 acggaggagc tgaggcacgg tggtcccagc tctcaggacc tcatcctgagtactcaatct
7021 tgcaagctct ttatctgctc ctgggccacc tgggggccag caccttgtctgacacccatc
7081 ttctccttgg agcagtgaag ggctgggcct ttagcctcac tgaccacacaggaattagtt
7141 tatttgcaac ccttgctctc tggactgagt ggagaaatcg cttccaagctccacattggc
7201 aggaggtggc catgggcaga gctcctgggg aagggggctg ggcagcaggaataggcagat
7261 gacaagcagt ttccagaaag tacctttatt acaacgaaag atgcctcagccgctcacctg
7321 tgtcatctag cagttcacag ttgtaggcgc cccaaaagac caacactgaccacaattcag
7381 agggaatgga cccgctctac aatgttcctt agcatctccc agcacatgcaaccactgggg
7441 gccaagcaag tcctctgcag ggggaaacaa gaaactggta aacacgcagagggagacact
7501 ggccccaggc tccccaaggc ttttgagtga aagtcaatgc cgggggaggtggtgagggag
7561 cccttggtga gctgtgccca ttggcagtgg ccctaggtag gccagagcagctggttgaaa
7621 tatggcttga ccttctgtgc tgtgccatcc aagacactaa ggaaagagccctcctgggct
7681 attgtggaaa aagttctgga tatggagtca gaagccctag atcctacctgggttctgcca
7741 ctcaccctca gtttcctcat ctgtaaaatg ggcatgataa taacactcacttcactagat
7801 tgcttcaggg aaaccatagg tatggaagag tttgtgggaa gagtattcaaatggtcgatg
7861 tgtttgtgag gcagccattc ccattctcct tgggagcagc tgctggcccctgaggtatct
7921 tctctccaga ccagcagagg gccccatgtg agatataaag ggaagaggagagcacgtcta
7981 aggggttcca gtctgccagg agaaggcaga gagcctggac tctgctctgtaggagcctct
8041 gctgagatgt tccgcaggaa cccaggcagg cagacccccg agactcctgttctcatctgg
8101 ctgggtgtgc accagctttg cccgtggcca cctcttttcc cactgccctcaggccagtcg
8161 gcccctcggt cagtgctccc agccagttct gtatctagct cttagttcttactgcccctg
8221 gctgctccta agctggtgct gccctgttca tgcatttcct gaacatgctaatatttgtgc
8281 acaggcctgg gaccctgagg tgaaggggcc agcctggccc tccaggagtcacaatcccat
8341 tgggtcagac aggagatagg gagtcctggg cgaatctcta ttgtgcctgcaggccacagg
8401 gctcagctgg gtttctcatt aacaaaatgg agacagtggt cctcatttagctcagaggcc
8461 tgcagttccc aggagtaatc aagagtgggc tatctaagaa ggagccatcttgaccacagg
8521 ttgctactca aagagaggaa gtattagctt caggtatttc ctttatcaactcctgagata
8581 gttccctaca tcaatcacag agccacagaa cgcagggtgt gaagggtcccgaagttcttc
8641 tagtccaacc ttctgtccag tgctgagcac caaggctggg ggacctggactgtaagggaa
8701 ccaagtgaca gacagtccag ggccaaccct gatgtctccc ttctctttctatcccctgag
8761 ccttcttgcc aagacatgag gtttggggat tttctgtgtg agataagaacatctaaaggc
8821 tggatctggc ttccacataa ttcactgtgg ctggaaattg gcacaaaggtttgcagggca
8881 tccccctcca ccttttcatt cttactcttc ttcccaccct ccccctgattcccaccctgc
8941 tatgttccca ctacattcaa cttccagcca ttcccaaaag ataccacacccttttacacc
9001 tccaaacttt gagacatcga tcatatttct tctgcctgga atgaccaccctccaccttga
9061 gaacgcccat taattctgct catccttcaa ggcccagctc atatgctacctcctccatga
9121 aggagtagta ctttgcacac aaagtactcc tctagcagta ctttgcacacattcttccta
9181 ctgctctgcc aaggtacatt gcatttcaga aactggccac acctctgcatgctgcccaag
9241 cttttgagca tcttcaggac agacatcaga catggtttct gtctttgagggattcactgt
9301 gtcatgggtt tgagttcttc cactgtggca ctgtcactct ttggctccatttccccaact
9361 gtgagctctc accccagaac tttctatcca aggaggatca agggactggaagaggcctca
9421 agggccaaga accaagaacc ttggctctta ctccttccat caacttccctaacccagaga
9481 atcttctagg gctccagagg ggcctaacga tttttttttt tttttttttttttgagtctc
9541 gctctgtcgc caggctggag tgcagtgcag tgcgatctcg gctcactgcaacctccagct
9601 cctgggttca agcgattctt ctgcctcagc ctctggagta gctgggactacaggcacacg
9661 ccaccatgcc cgactaattt ttgtattttt agtagagacg gtgtttcaccatatttccca
9721 ggctggtctc aaactcctga cctcatgatc cgcctgcctc ggcctcccaaagtgctggga
9781 ttacaggtgt gagccactgc gcccagtcaa gcctaacaaa tattagcaagttcagctcca
9841 gcccataggt gggaagcaag agggattgcg tgtgtaagcc agagtcagttaggggaagac
9901 agaggaagga gaaagggcag acgggaaagg aggtgggagc aggctctgagttggcccccg
9961 gagctcagaa gggaggcggg agtttttatt gagcagggga aatgggcggtatttaagaag
10021 ccaccgaagg gtcttagttc attggcagga tcaaaggcca tgaaagggccaggcgtggtg
10081 gctcatgcct ctttccgagc cttactgcga ccacacgtgg ggcaggatctcaccatctga
10141 cagaggagaa gaaacataca cacagaggtg aaatgagtgc agcatacaggagggccagcg
10201 gtgggggtaa atagcaacaa tgttcagagg atgacagctt acttagagctacagagacga
10261 gggaaaagga gcaggaggag gaagtgccta agctgggtct tgaaaaactgcccctgtttg
10321 tacctatgga gatgcaggaa gtgaggaatt ggtgatggag gaaggtgaagtctttttggg
10381 tgagggaccg accagaccag aggccagagg aggagaattg cagccaagttccatgtcggg
10441 gaagccacac catgtagctg gagcagaggc tataggaagt agaagagggagaccagctag
10501 ggagggagca gtgggcctgc tgagtgattg tgcagggaag ggttgcagctgaggcactgg
10561 ggacaagatg tccccctact gttggctgca ggctccacct ctgactccacattacattta
10621 ttttccccag taaaatgagg gagccctccc tcttgatgat aaatatagctactatttgga
10681 aacttatctg ccgcccctgg taaaggaggc agaataccca gtgcacccacccctgaaatg
10741 ctcctgcaat gcctaggcct gtctgtgggc tgtggtccag cctagcaccccctctcttgg
10801 agaatgtgag gttggcattg tccctgctga aggcagcaat agaggggacccttacgacga
10861 ccttggcagc cggtggctgg ctgtggacac agccctgcgc ttttgttttagtcctaacgg
10921 atatgccccc tgcatcctcc attcttcaca gcacactcag tccccctcaccacacctgag
10981 ggaaatcttc tctgcctaat gccccacgta gtgaatgttc tcccctcctccctcccccag
11041 agcaagccat tgcacaccag cgaagggcag acagagcaca cagaaaattccccagacttc
11101 tgctttgata ggaagtgtat tttcatgtaa tggaaatgat tgtaaaactgccttcccctg
11161 caaaagccct caggaatatg ctgctggaaa tgtgcttgag aacagacttgcaaatcattt
11221 ctctgaattg ggaagtcttg gttatcttag ccacttttac cgatcatgtgaaagccacat
11281 ctctcgcacc cactcccatc cctgggtctc atttttttct tttttctgtcgcccacgctg
11341 gagtgcagtg gcacaatcat agttcactgc aacctcaacc tcctgggttcaagcgatgct
11401 cccacctcag cctcccgagt agctaggact acaggcacgc accaccatgctcagctaatt
11461 tttgtatttt tagtagagat ggggtttcac catattgccc aggctggtcttgaactcccg
11521 ggctcatgtg agctgcctgg ctcagcctcc caaagtgctg ggattataggcgtaagccac
11581 tgtgcctggc cttttttttt tttttttaac tttttatata taaaaaaactctcaaataca
11641 tacaagagtg gggagaacag tatcatggcc ctatgttgta ccatccaatttcagctacca
11701 tcaattcatg gccaatcttg cttcatttgc atcccatcct acttcctcaccccaaattat
11761 tttgaagaag atcccaaacc ccataccatt ccatctgtaa atattcagtacacagttata
11821 aaagataaga gctcaaataa ataccacata ctttgtcatt ttaaagaaattaataacaat
11881 tccttagtac tataaactaa tcaggcagtc atcaaattcc taattgtctcatcaatgtca
11941 taattttttt ccaatttatt aaaagcttca ttttaatgtg ttttgtaaatcaggtattta
12001 atcatttatc cactcgttct gttgaagggc agccatgtgc cacgcactgggggatggtgg
12061 ggaatgagac agatgtggtt cctgtcctca aagggggaag atgaccactgcacccatcat
12121 catgaggagc tttatggaag ggaggcacag gtgcccaggc agctcatggtgaggaaaccc
12181 acttagccca ggatgggggg aagccacccc agtgcgtgag ccagagtcagttaggggaag
12241 actgaggaag gaggaagggc agatgggaag ggagggagga gcaggctcctagttggcccc
12301 tagagcccgg aagtgagtca ggagttttta ttgagcagga ggaatgggcggtatttaaga
12361 agcccttgaa gggtcgcagc tcattggcag gaacaaaggc catgaaagggctgggcatgg
12421 tggctcacgc ctgtaatccc agcactttgg gaggccaagg cgggggggatcatttgaggg
12481 caggagtttg agaccagcct ggccaacatg gtgaaaccac atctctactaaaaacacaaa
12541 aattagccgg gcgtggtggt gcacgcctat aatcccagct actcgggaggctgaggcagg
12601 agaatcgctt gaacccagga ggcagaggct gcagtgagcc gagattgtgccactgcactc
12661 cagcctgggc gacagagcga gactctgtct caaggggggg aaaaaagccatgaaaggctc
12721 catcccaggc agaggggcta acactagtgc agacgtggtg gtgtggagatgcatcagggg
12781 agtgtggagg ggagaccgga aggcagggca cgggggacgc agccaaacacggagggtctt
12841 tggtgtcaca ctcttagcag gagaatggga tgctaagatc ttgttttggagagaaggctc
12901 tagaggtgag gactgcgggc agggacactg gggaggaagc ccggggcaggcggagggctg
12961 agtgcctcag caggcgccat gagagaggaa ggagcggcgc tgggatcaggggagtgagtg
13021 acagggcagg gcaagagtca attgtggtcc tggggaccac cgcggacccagggatttggg
13081 gtacagggcc ttagttgatt ctcatctaga caggtgccag ttgctgacaccctgaattct
13141 ggcaaacatg gagacatcag ggtggaaaca cctggagcca ctgccatccaggtgggcgcc
13201 ttgagggcca ggccccttgg ctgctttccc agcagcagca tggagcctggcacagaacag
13261 acctggcata gaagtgggag caaggaacac cgcctgtggg tgcaggagcagtgatcagtt
13321 agcaacaggg gcccccctgc agccagccat ccaggcagca ccagacagtgatccatttct
13381 ctcggtgaca gttctagaaa aggctccgga gacagggact atcatgtgatcatttttacc
13441 ctagaccgct tgaccgcttt ctgtctgaac tgatccacct gctagacgctgcctcaacag
13501 tcctcgtttc tattttattt tcttttactt caaagcagaa gggctaatctgctgaggtgg
13561 agacgagttt tcacccactg gctttttttt ttttcagccg aagtttaaggtaaagtcagg
13621 actgcagttt ccacaatatt tttaccctat cggagagtaa aagagtcaccctcccattat
13681 acctcattgt attcccagtg cctggcacag aatgggtact ctacacacttgtggatcact
13741 gggaccacaa gctcctctgt caccgtaaca ggggaatcta ggacccagcagttgatgact
13801 gtgtgggtgg cactgtccaa ggctcaaaga caaataccac aggcccttcctgcctcagtg
13861 ccagggtctg aaaaatggga accagcgctt tcagtcggtt gcagggcaaagtcagagttt
13921 gagtgaggac ctggaagaag ggtttgagct gagccagaga gatgggatttatcatccctg
13981 ccctgcccct gcctctcaga tgaatccctg acccaagcct aagtttccatagtgtaaacc
14041 tggatgttag cagggtgggt taaggggaaa tacatgagtg gaggtagaaatgatatttta
14101 gtacaatttg tggataataa agggttagag ttccatgggg cctccatttagctgagaaat
14161 ggggaaaatg gaaggggtaa ccttttccag tgggaggccc agggactctgcagtatccca
14221 agtctggctc tgtgagtcat tggtgatttt cagagagtat actatgtaagaaacatgagg
14281 aacagctgct ttcttggaca actctttgaa gtgaatttct ttcttctaccatgccatcaa
14341 ctgtcattat aaaattgaag atgtgtttct catggggaaa aaaattgttattacaagaga
14401 tatgggcaat tagacaagtc tcaatacatt tcaaaagact gaaatcttacagagtatgtt
14461 ctctgaccat agtggaattc agctaaaaat caataataag aagattatctttgaaagttc
14521 caaatatttg gaaattaatg cctttcttaa cctatggtca aagaaggaagtaaaagagaa
14581 attatgaaac atttttaact gaattataat gaaaatacaa catattaacatttatcattt
14641 taagtactta cagcagaaaa gaagaaaagt gtaaaattgt aatctaggtttctgccttaa
14701 aaagatacca aaagaaaagc aaattaaacc caaatcttga aaacattatgttaaataaaa
14761 gaagccagac acaaaagacc acatactgta taacctcatt tacagtcaggcatcgcttag
14821 tgataggagt acattctgaa aaatgcatca ttaagcgatt gtgtcattgtgtgaacatca
14881 tagagtgtac ttacacaaag ctagatggta tagccaacta cacacctaggctacatggta
14941 tgacctactg ctcctaggcc acaaacgtgt acagaacgta actgtattcaatgctgtagg
15001 caatcatagt acaatggtaa gtatttgtgt atctaaacat agaaaagatacagtaaatac
15061 aatattataa tcttatggga ccactgttgt atatccaagt ggtcgttgaccaaaacggtg
15121 ttatgtggtg catgaatgta tacgaaatgc tcagaacagg caaatccatacagagaggag
15181 atttgtggtt gtcaagggct gtggggaggg agaatgggga gtgactgctcacgggtatgg
15241 agtctccttc cagggtgatg aaaatattct ggaattaggt agtggtgatgggtgtacaac
15301 cttgggaata tactaaaaac gactgaactg tgcactttag aaggatgaatgttatggaat
15361 gtgaattata tttcaataaa taaaaatcaa acacccccca ccaaattaaacccaaggaca
15421 gtataaaagg aaggaaatag aaaatagaca acagagaaat ttaacaaagccaaaagttgg
15481 ttcttcaaaa aaaattaata aaatagataa accctagcaa gacttatcaaaaataaaaag
15541 caagaaaaca caaattacca atatcaggaa taaaagaggg aatatcattacatttaaagg
15601 aaaatatggg aatattacca ataacttacc tcaataaatt ctacaactcagatgaaatga
15661 ataaatcttt tgaaaaacaa cttaccaaaa ctgacagaaa aagaaatggaaaatccaaag
15721 agcctccata tctattaaag aaattgaatt tgtaataaca atgatgatgatgacaataaa
15781 cttccttcca caaagaaaac ttcagatcta gatgatttca ctgctgtattgtagaaaaca
15841 ttcttttttt ctttttttga gatggagtct cgcactgtca cccaggctggagtgcagtgg
15901 cgcgatctca gctcactgca acctctgtct ccccagttca agtgattctcctgcctcagc
15961 ctcccgagta gagcagctga gactacacgc aggtgccacc acgcccggctaatttttgta
16021 tttttagtag agacagggtt tcaccatgtt ggccaggctg gtcttgaactcctgacctca
16081 agtgatctgc ccatatcggc ctctcaaagt gctgggatta caggtgtaagccaccacacc
16141 cggcctgtag aaaacattga aaggaaaacg taataacaat cttacacaaactctttcaga
16201 aaatagagaa ggaagagcac atctcaattc attttttatt atcaaaacctgacaaagacc
16261 ttacacaaaa agaaaattac agcccaatat ctctcatgaa cacagatgtaaaaatcctta
16321 acaaaatatt agccaactga atagcaatat atgaaaagaa taacacatcatgacaagtga
16381 gtattatccc aggaatgcaa tgttaattta aaagtagaaa atcaaaatattttaccatat
16441 taacacagta aaggaaaaaa ttcatgatta tatcaataga tgcagaaaatgcatttgaca
16501 aaattcaaca cccattcatg ataataacta tcagcaaact accaataaaaggagcttcct
16561 caatctgata aaaatcatcc agctaacatt atacttaatt cagaaatattgaacattaag
16621 atcatgagtc aggcaaagtt ttctactctc accacttctg ttcaacactgtgctagaatt
16681 ctagccagta caaggtggca aggtaaaaac aactcctaca gattggaaaggaagaagtaa
16741 aactatcttt attcacagaa aacctgattg gttatgtaga aaatcctaaggaatctatta
16801 aaaagctact acaattaatg aatgaattta gcaagttttc aggatatatgattaatacac
16861 aagaaaataa attttaccaa agacaggaaa gacttccacc ctaaaaacaaaacaacacaa
16921 aatgctgaga gaaataaaaa aaaaaaaaaa ccaaacatgt agaaaatagattatgtttat
16981 ggactgaaga ttcataattg ttaagatgac aattctccac aaaatgatctatagactgaa
17041 tgcaatccta ataaaaatca caacaaacta ttttgtagaa attgaaaactactttaaaat
17101 ttatgtggac atgcaaatga tctagaatag ctaaagcagc cttgaaaatggagaagagaa
17161 ttggagggtt cacaccacag ctgacccctg aacaacatgg gtccacttatatgtggattt
17221 tttttttttt tctttttgag acagagtttc actcttgttg cccaggctggagtgcaatgg
17281 agcaatctca gctcactgca acctccacct cccgggttca agcgattctcctttctcagc
17341 ctcccgagta gctgggatta caggcatgca ccatcactcc cagctaatttttgtattttc
17401 agtagagacg aggtttcacc atgttggtca ggctggtctc gaactcctgacctcaagtga
17461 tccaccagcc tcggcctcct aaagtgctgg gattacaggc atgagccacttcgcctggcc
17521 atggtttctc ttccttatct tttttcctaa cattttcttt tctctagcttactttattgt
17581 aaaagtacag tacataatac atatacaaaa tatgtgttaa ttggctgtttatgttatcat
17641 taaggcttct ggttaacagt agtctattag tagctaagtt tttggggagtcaaaatttat
17701 atgcagcttt tcaactatat gaggggctgg tacctctaat ccctgtgttgttcaagggtc
17761 aactatattt aattataagt ctaactataa agttaaagga attaagaaagtgtggcattg
17821 gtctaagaat agacatatag accaatggag cagaatagtg tccagaaataaactctgtac
17881 atataaaatc aattgatttt caatcaaggt gttggatatc tagaactaggtatctatatg
17941 gagaaaaaat gaacttcaaa ctcctacctc ataccatcca caaaaattaatgtaagatgg
18001 attatagaat taaacattaa aaacttataa gcttctagaa gaaaatatagaacatctttt
18061 tttgtattct tgggttaggc aaaggtttct taaagaaaaa ttttaaaagactaaacataa
18121 gaaataaatt tcactaaaaa cttgcatttc ttaaaaattg gaaactctctttggctagtc
18181 acagagtaaa aaaaattgaa aactcctatt cataaaaaaa tcacatttaagaaggcaaga
18241 gaaggcaagt cacacacagg aagaaaatat tcacatttat ctgacaaaggacttgtagcc
18301 agaatatata aagaatccct ataagtcaat aataataaga caaattatgaaattttttat
18361 gtaggcaaaa gacttgaaga gacactccat agaataagat agacgtatggccaataaaca
18421 tgtgaaaatg tgatcaacat cctgagtcat tagagaaatg aagatcaaaattacaaagag
18481 atattatttc acatgctcta aaatagctaa aatgtaaaag tctgacagtaatcaaatgtt
18541 gatgaggatg gaacaactga aatttttttt acattgctga taagagtgtgaaatgatgca
18601 atccccttag aaaactattt ggcgatttct ttcttttctt ttctttttttttttttttgg
18661 gatggcatct cgttctgtca cccaggctgg agtgcagtgg tgtgatcttggttcaatgca
18721 acctttgcct cccgggttca agcgattctc ctgcttcagc ctcccgagtagctgggacta
18781 caggttcgca ccaccacgcc tggctaattt tttttttgta tttttagtagagacagggtt
18841 tcaccgtgtt agccatgatg gtctccatct cctgacctca tgatctgcctgcctcagcct
18901 cccaaagtgc tgggattaca ggcatgagcc attgcgcccg gccagcaatttcttataaag
18961 ctaagggtac ctatcctgtg acataaccat tctgttctta ggaatttcctcaagagaaat
19021 aaaattatat tttcagaaaa agactcacat gaatgtttac agcaactttgctcatatagc
19081 ccaaccctag aagcacccaa aagtttatca tcaacagaga aatggaccaagaagttgtgg
19141 tataggcatg caacgggcta ttactctaca ataaaaatca atacattacttatatatgca
19201 acaacatgga tgaatcacaa aaacattacc ttgaccaaaa gaagccagacacacaaaaag
19261 tacattctgt aggatacctt ttatatgaag tttaaaacag gcaaactgatctttggtgct
19321 agaaatcaga gcactggtta ctaagggact agaaatcgac tggaaagggacatgagagaa
19381 catgtggaac aaatggaaat gttctatgtc ttgattgtgt ggcggtatacagggaaatgc
19441 atttattgaa actcattgaa ttttacactt aagatccatg aatgtaagtttcacctagtt
19501 ttaaaaaaag aagagagact cacatctaaa atacctaaaa cttgaaaaatattatataag
19561 atgaggaaaa aaattatttc tgattccatg ctactaaaaa taagctacaaatgtgattca
19621 taatagaaga agccattttt atatttagca cataacttaa aggtctaaaggacaagcaag
19681 ctgggcgcag tggcccacgc ctataatcct agcattttgg gaggccaaggcaggaggatc
19741 acttaaagtc aggaatttga gaacagcttg gccacatgct ggtgaaaccctgtctctcta
19801 aaaatacaaa aaaagttagc caggcatggt ggcacacgcc tgtaattccagctacttagg
19861 aggctaatgc aggagagtca cttgaaccca ggaggtggaggttgcagtgagcggagatta
19921 cgccactgca ctccagcctg ggtgacagat caagactccg tctcaaaaaaataaattcaa
19981 aacaaaatag aatgaaggag aaacaagact atttagtaga ctgagaatagctgtttctta
20041 ttgagggata aactgcacca aatgctattg taagcattat tatttccttcattttaaggg
20101 tgaggaaaca agggcaaaga gaagttaatt agcttcatcc agggcacgcaaactaggaag
20161 aggcagctgg gatttgaact cagggactct ggcccaagag ccttaacctctatcccatgc
20221 cccctcgtgc ttgtaaagga cttgatgctt tacttagact ttcccacaacagtttcttgt
20281 catcctcgtg atggtcccag gacacaggct ggtccaggat aatgacccccggctaacaga
20341 tggtgagtct gagaccccaa ggggttggat ggccagctcc caggcctccagaccatgggc
20401 cgttgtgccg ggccgcacac ctgagtgggc ctggcttttt cctgcacgcaggggtgcttg
20461 ggccctgctt cctggtgctc catgggagta tctggccttc aaaaggaacagatcgatctg
20521 aagtggggag agagaaaata cagcaggacc atcactcaga gagtcgctgtagaggaagag
20581 agggagagga gacgccagga catgggagct ttgtgggagg gaatgggactatttgctgag
20641 ctttgtacag cccagcccag gcagtgcata caacaaggct ttgctgattttaaataacac
20701 aaggaaatag cagccccagg tctgagtcac cagcagagtt ttactctatttctcagctca
20761 cacagggaca atagcaatgg caggcactgc tgggagatag gctagtgggctgggccctgg
20821 caaaatcacg acgtccttga aaacagtccc aggaccttct ccttccccttcggatggccc
20881 accacctcac cctctgccct ttcgggaccc cagcccctct ccagtcttgcttccacaggc
20941 tgctccctga gggcagacca ttcttgcttt tcccttcacc atcgggactcccctgtcctg
21001 tgtccagctc cttggaggct ctactctctg ctctacgctt tcaaacatttccttacactg
21061 ttctctctgc ctggatttcc ctccttctcc ttgcttccca gtctctctgaatatccagat
21121 ttcttctggt cttctagcgt caatgcgtgt gcctctgcaa tgcctccttaatccactaca
21181 ttgagagtca ttgctccttt tcctgtgttc tcactttatt tacactttttgcatgccaat
21241 gacaaaattc tgccttgtat catcggcaga attttccatg tctgatatatctccctctgg
21301 attgtaatac gctcttaaag gcatcgttca gattcgaatg atcttagtacaactcccctc
21361 tgtgaaggcc aaatggcaca caagccagga gctagaaagc cctggttgcctgtggaaatg
21421 aatgaacaca catgggctgg cagccgtgtc cctgcacacc tgccttttctcagaggtgtg
21481 gccctagcag ggtaagctgt ctggaagagg gagctatttt gtgcagatggaacattttgt
21541 ccccttaaat catgtcccat gaaaggccag catggcatcc tgcttctgaaacaagcactg
21601 agctcgtctc catttggaga agatctgtcg tgtgggtatt tttaaatggtgaaaggagaa
21661 atgggtatat ctgataccat ggcacttgtt acactttaag cacagactctgttattcata
21721 ctccatctat tgactcaggg aggagtttat ttcaaaccaa acagctcagctatcccagga
21781 gcagctgcct cagaaggaag gaggatgctg ttctatttcc cccatcgaacctccttctca
21841 ctcgatccac aacagccttt ccatgcaagg aagaggctat tttctttcaagctttattct
21901 ccattttccc tgtggcaaga aaggtgattg gatattggga tttgtaatggttttatctga
21961 aagccattta aaatgaagct ggaatgtcaa caagactgac gctgaatggagtagatgtga
22021 agtggaaatg aacttgaaac aagagatggg gttagtcatc cccctgatcacttggaacag
22081 atgatggagg tcccctgcct ctgctccagt gaacagaaca gaaccacttgaatactgcca
22141 gccactgttt gtacataccc tcctgaaacg gctcttccaa aatgctgaaggacattttgt
22201 tttcttaata atttggcctt tccactgttt ctgtatgatt gatgtgtttcagcaaacctt
22261 ttttaaaaaa gaatatctac aggtaaattt agctcatcat gtttgagaatattcaccatc
22321 tctaaatccc cagggcctaa atcaatgagg ttttagcaca ttttgaaacagaaccctgat
22381 gtataaattc tgcaatggct gatttcacgt attttacttc ctctctaacaaagctatgga
22441 aaaatgcaca agcaggggag ggtttgatcc tcggtgtttc ctgcagatgtgaatctgaca
22501 ccaccttgga gcagggcccc tccccacctt ctcccaatcc tccgctgggttgctgcattt
22561 ttcactccaa gagaccccgg aggacagcta tatccgaggc ttattaaaatcttctaggat
22621 gcaaaggcct ttggttattc agagcagcag gtctttaggg gaagcccccatacacaaaca
22681 tgctcagctg attctcaatt tatattgtgt gttacctgcg gggaaaattaaaagctcaaa
22741 cctcaggcac tttccctctc ctcccttgat tgcccggggg cttgttgttgagatatttct
22801 tgttgatttt tttgtttttt atgtctctgg ctggtgctaa acattctttctttcccatca
22861 tgtttacttc acatctcttt gccgtataga tagcttctgc tttatggttttttcctcctt
22921 atctcagatg cagccagccc ttccccacct gcccccgccc caaaacacacacacgaacac
22981 acaccctttc agactgcatc cacactctct gtttcagtgg atctgacatcaacgaccccg
23041 ccacccccgg ccctcgtcag aggggagctc tgcattgaac taggactagctcctgggtca
23101 taaaagttgc taggaccctg gagagctctt actaaacaga tgaggccaccactgacagag
23161 gagagaggtc agttcccgga gggaacgagc ctgctttgct gagcccccttccttgcccag
23221 cccccagacc catcacaggg aaggttcaga ggagctctga cccctccagtacctccttgg
23281 cctgacgccg ctctagcccg ggctcccagg ttttctgtag ggagaggagcacagtccgct
23341 ccacccatgc catgggcttc atcagtgaca acccaaactc acccccaaataggaatggct
23401 tcaacctgga gacagccctt caatgaaatg gtttatgctg gtggagatttaaaggtattc
23461 gtctttcggc tgggcgcggt gactcacacc tataatccca gcactttgggaggccgaggt
23521 gggagatcac ttgaggccag gaattcgaga ccagcctgac caacatgcgaaaccccatct
23581 ctactaaaag taaaaaaatt agctaggcac agtggcgcat gcctgtaatcccaactactt
23641 gggaggctga ggcacgagaa tcatttgaac cccggaggca gagtttgcagtgagccaaga
23701 ttacactact gcactccagc ctgggtgaca gagcaagact ctgtctcaagacaaacaaaa
23761 agggtgtttg tctttcaatt gcaaaaatca agcatggtca ctgaaaaaaaattcaaattc
23821 acatttcatt ttgttttgtt ttgttttgtt tgtctttcag ccaggtgcagtggctcacat
23881 caaagtatgc tgctttcaat atcttctcac tctccctccc cagggataaccactttcttt
23941 tttattttat ttatttaact tttttgagat ggagtttcac tagttgcccaggctggagtg
24001 caatggcgca atctcggccc accacaacct ccgcctcctg ggttcaagcgattctcctgc
24061 ctcggcctct tgagtagctg ggattacagg catgtgccac cacacccagctatttttgta
24121 tttttagtag agacggggtt tctccatgtt ggtcaagcag gtctcgaactcccgacctca
24181 ggtgatccgc ccgcctcggc ctcccaaatt gctgggatta caggcgtgagccactgcgcc
24241 caggggggta accactttca gtggtttgag atgtttgtct cttcatagaagaaatatatg
24301 catatagttt gggttttggt atttttttta attaatggag ttctaatatacatgctgcct
24361 tttttccctt accatggaat tgacacagga taataaatta attctaagcaacaaattttt
24421 ctttaaccca tcctgtctct aggtttctcc tcacagaaat tacaaccccttctcttgtgg
24481 ttccatccca tccctaaaac agtatttatc ctcccttctc tgtaccattactgtttcttg
24541 tgcgaaattg taccttggag tatgtactga atggtgttgt actggaggcctggcgcggtg
24601 actcatgcct gtaatcccag cactttggga gaccaaggtg ggcgggtcatttgaggtcaa
24661 gagttccaga cgagcctggc caacatggtg aaaccccgtc tctactaaaaatacaaaaat
24721 tagctgggca tggtggcggc gcctgtaatc ccagttactc aggaggctgaggcaggagaa
24781 tcgcttgaac ccaggaggcg gaggttgcag tgagccgaga tcgtgccactgcaatccagc
24841 ctgggaacag agcaagactg catctcaaaa aaaaaaaaaa aatggtgtttcccttgcact
24901 ggtgccctgt tggctcctgg cctcccttct agaccatcag ctacctgtgggtgggagcct
24961 gtgcctttgt cattggtcca tcctctatcc cgaggccccg ggacatggcctagaacatca
25021 gagactccag cggctgtttc tcaaagtgaa ctgaactagc tggtgtttcccacacgatgg
25081 agccccctcg acctgccctc gattctctcc tgacttattt ctccccacatcttgggccag
25141 ttccagctgg actagcaaag agggcagctt tacctctgtg ctcccaacatgccctagtgg
25201 gtggcgtatg gatgggggag cctgggacaa tgtgtgtcca tctcacacactctctacttc
25261 ccatgccagt ggggaaagtg ggggcaggaa tagagcccgg gagggaactgccagagactg
25321 tcttctctgc taaggctgac aggaagacgg acaaccatga cagtggtggaaggggaaggc
25381 ccttggccca cggggaatgg ctgtctggaa gctgacttgt tgttgggggcctggtttggg
25441 caggaacccc tggggtggct gcagaaggag gctgggcttc acagacccctgtcggcaggc
25501 aggggctacg ccccctatac taggcttctg ctcagggcag cagggcccggagccaccagc
25561 agagctgagg aggctgcaga ggaggctgag agatccatgg aggaagaacatggtggaaaa
25621 gagtgcctga ggtccgcttc cacggccact ctgaccagcc tgggccttctgtgccttagc
25681 attcccgttc ctaacatgga actcatggcc tttgacccgc ttccctcacgaggctgctga
25741 gagggtcaga gaagaagccg catggggact ggcctcaccc tgggagaggtgagcaagcca
25801 cgaggtccca tgttgcatga aaagtcaaat gctgttagga cgactcccaggatgaggagg
25861 tctgacccca tgctcatcgt ctggacagct ctgaccctag aatttatttcctctttcccc
25921 acagggcaat ccttctactc tcgggtcctg gagaactgtg aggatgtggctgactttgat
25981 gaggtaggag gcccaagact cccccctccc tcagccctga gcccagaggggaacagccac
26041 ccttcgctgc ctcttgcggg cacacactgg ccccaaatcc caggcactggcctgctctga
26101 gcccctcacc tctcagctgc ttcctgaagg aggtggtaag gagggtgtgcaggaactccc
26161 tcccccatgt tccccccaga aacctctgca caggtgaggc ccgtgtgcaaatgacacggg
26221 gaacagcagc ctcgcccacc tcgacggccc tgctgggtct gggcctgttattccctgtgg
26281 agaaagagcc cacaggtgct gtagacctga atgtgagcca ccagctgagggcccaacgag
26341 gcaggcgagt gttggggacg tcgcaaaggc cagtctgtgt cagtccccaggggttgaaga
26401 gcagggcagc cccgggcact gaggtaggag ccccagtcac cagggaaacattgtcaagca
26461 ccccacctga gtgagggcgc catctccaga ccttgagggg aagcatagggaacagaagac
26521 agtctggatt ttcagaaaca gctctggggg ttccatgaga aaagacgtgagctgctggtc
26581 tattgacaac gatttttctc aatcctcact ccagctgggc tgttgtcacaattttatcag
26641 caaaggagca ggcgacacca tcccacaggg gtgcccagga gcagtgagaggacttacaac
26701 gcttccctct ccctgccctt cccctcggta cctggccggg ctgggagccctatcctcaca
26761 cacacacacc agctcgagca gcctgcggcc tcctccgcct cctcacattctttcgtctat
26821 gtgtttgctg cttccagaat ctatattccc ctctggctgc tgtaggttctccagggatga
26881 ctttggagtg agggccagca gtcatccgtc accatcttag cacaaactggaagccatgta
26941 gtgaccctca aatagtgtac cccctctctc ctggggttgg ctctcccgcttggctctgtg
27001 ggggctggga agggcctcat agcagactgt gcctcttgag gttggctgctggcgttcggc
27061 tgagcagcca ccaggctgac acttggcacc agctgtctcc ccctcctccagaaaccaggc
27121 cacacgatgt ggctgtgtcc atcgacccag agctggagac acagggagcaaaacctcgct
27181 cctcactcag gcttaggcac agccatcaac catcgcggcc cagcaccacaccctccccaa
27241 ccacttcagg gcgcagttgc cacgacctcc ctggtacgtc cccactgctatgcaggacag
27301 gtgaatcact catttaaagt gaatcactag agctaaggaa gtttctgtccttaccttctc
27361 cccctcctgg ctgtacaatg acctcagttt ctaaacctgc caccatctttgtcaaatggg
27421 gttggtgatg ggtgtgaagg tctctgtgaa atgatgaaca aaatgaagggttatggtgag
27481 agtggaatca tggctgccca ctgagacagc tgtcatagat gcttcaggcttgccccatta
27541 cacacccggc ctgctccctc ccctccccat ttcctcagtc agggcactgggctggctggg
27601 agaagatgcc agcagcctgg cccagtttcc catagtccta cctccctgggcttctgccca
27661 ctaatccacc aggcacagca tctgactccc tcctcccaag actcccaggggatatgtcag
27721 cccaggcgtt cagccagggg gcaacctgat gccccttcca agggcactgccacccttttc
27781 catgcccagc gccttggaca cctgagccac aggtatgcac gacattcaaagttaatcacc
27841 atgtcgttcc tcttcccaac tccgcccagc ctgcctcagg gggagagtctgtctctgctg
27901 gccctgaaca aggggccaca ttccgagcat ctagtgcatg ccaggccgggcttgagatat
27961 cccagaggca ggaacctggg ctcaacaccc catgatgatt tgtatgggagcttagggatg
28021 gggtagccag agtcagtgtg gagagactgg ggcagggcag aagcagttatggaagaagca
28081 catgactagg gtcagagagc agggcacgcg atggggagaa gaggctcctgcccggggaaa
28141 gtgctgcccg cccactgggg agacagggaa gtttctggtt gttgcaatgaggagcctact
28201 ggcatttagt ggggtgggga gcaaggatgc agaatgactt gcaatgctcaggccatcccg
28261 cacttcccac ctgggagccc cgtgggaaga tggtggcagc cccagcagcagcactgagct
28321 gcttcccgag ccatgcccct tccactcaat ctccgaaatc atccacagacgaaattaggc
28381 tcagatggta actacccttc cccaggtgac agagctggaa gcggccaagccagggttctg
28441 aattcatgca tagattagac ctaagccctc tctggataca gtgatagggcctgactccca
28501 ccacccctgc aaggcccgtg ttggagtctc tccacacccc ctgcctccatttctccctgg
28561 gcaaagtggc ctcagccctg gccaccaatg gtcagcagtg cacatcccacaaagcaggaa
28621 ggccaccctc ccattccctg ttcaggaacg gcccggaggc ctgggtcagcccagtcccaa
28681 aggtagcctg gagccatacc ctggctttaa cctttctccc tagacccagtggacaagttg
28741 taaacttccc tggcttcccc ctgaaagaat ctgcctgcca gtggttccagaatatcctgg
28801 gaaagagccc tttcaaatcc ccctgaacct tcttgacttt ccagaaagcctcttctctcc
28861 gtcttactct gcccagggcc tgccggagcc agcttagtgagacacactggcctgggagtc
28921 atgagaccta caccacagtc cttgctgagg aacctctttg ggctttggattccccttctg
28981 taaaagagag atatgctccc tgctctatct gccccacggg actgtcacaaggctaaaaaa
29041 agatgaaatg agagacaaga aagcaaatgt ctctcacagc tctactaggtaaggggttcc
29101 aagcaaggga ggggcccctc ctctgctcag gcatgggtga gaggggctgcagcagctggg
29161 cttaggaacc tgagtgggga ggaggatgcc atggaagaaa gacaatgctctctacaacaa
29221 tgggtggaaa cagagcctgg acatggtgtc tcctttccca gaggctggaacctgagcccc
29281 tacatttaac ctacaactct ggaaaagcta gggagagaca gagaaagacccagcctttgt
29341 gacctgggga aacaggagta gccaccttta gccagtttgg tttggctctaacacaggccc
29401 tgtgtggagc aggccccagg ggagaggcca gagtaacaat agtacttgtgccaatgataa
29461 gaagaactgc tgctatttac tgagcactta gtgtgtggca agatgggctgagagcttgac
29521 acaagcatta gactcactag aacttgctgg attggtagca tcctaggtgataaggagcca
29581 caacaggatt taaacccgag tctatctgat tccaggacct atggtcatttgtaaagtaga
29641 caagactcag ccctgccctc aaggggctca gtctagcggg cagatggacccactacaaac
29701 aaggagggac cctgggcctt ctgagccaag aggaagaaga ggtctccagcctgggggatg
29761 acagggcagg ggagtttggc cttatctgcc cctttctgct tgtaccaggaagtcatggct
29821 gttacctcct ggaggccaga aacgcacctg tcttgttcgt cattggcctggcacccagca
29881 tggagttgag aaaatgttgc cgagtgaaag aatgaaaaaa acagtgacgttcactaggac
29941 tggcacctgt caccgcaggc ctgtgcccag accgagtggg ctcagcagggctagtggtac
30001 atcaagccct ttgctgtggc ctggatagaa aggaagcagg caaggcacagatgagatcac
30061 ctaaagggac tttagatcac cttgatctct aaggttagag atcatctagtttaaccctct
30121 tgtcttgcag ttgaagaaac aggtcttaga gtggggaaga gaattgcccaagaagaccag
30181 ctgagatctg agatcctaca tttaacttac aactctaaag aagctggggaaagagacaga
30241 gacaaagaca gaaacagaga gagagagaca gagacacaga gacccagcctttgtgccctg
30301 ggaaagtgaa atagccacac tcgggatact gagcccaggc ctttaagcttgcaaatccgt
30361 ctctttccat tgtactctaa agcagcagtc cccaaccttt ttggcaccaggggctggttt
30421 cgtggaagac agtttttcca cagactggga tggtggtggc tgggggttatttgggatgaa
30481 actgttcctc ctcagaacat caggcattag attctcttaa ggagtgcacagcctagatct
30541 cttgcatatg ttgttcacag tagggttcac actcctatga gaatctaatgctgtcactga
30601 tctgacatta gatggagctt aggcgggaat gctcgctcac ccgcggctcacctcttgctg
30661 tgtggctctg ctcctaacag gccatggact ggtactggtc tgtggcccgggatatgggga
30721 cccctgctct aaagctttgt agtgcatctc aatattttcc cccaaacctatagccctgtc
30781 cctttaagga tgctaccttg ctgatttagg atggttccag gcccactcagcggccaagct
30841 ggacataatc cagatcattc tccaaggtac atcagggaaa ccttttttgcagagtcctag
30901 atcactgggg ctgataggat gcagaaccct gtgccccggc cagcaccagccaggtcaggg
30961 ctaagcctag accaggaaac tgggtcagga ctcagcactc cccgggctcctgagatcact
31021 ccctccaaca gaggccctct ttccctccct atctgtacta cctaccaccttgcttctgtc
31081 aacagtccta tcccaggctg ctattccagg tctgtgtctg tctccagaactatccaggac
31141 catccccagg actgagaaac aaccctgcat ccctgcgttc tgcacagcgtcatgcacaga
31201 gcctggcaca cagcaagtgc tcagcaaatg ttcgccccca gcatggggcttgctggctcg
31261 tgacatcttg agtgactgtg tttggcttaa ctgctacttg agtcccccagcagtaccagg
31321 cttcaggaga ggattcagtg tagtggatta agccctgagg actgaactccagactaagca
31381 tcctgagact tgagtttgaa tcctgcctct gccaccaacc agccttgtgcccgcgggcaa
31441 ctctcgcctc tccactttcc cacttgtaaa aggagcacat ctttgccatgttgctgtgag
31501 cttggttatg ggtaaatgtg ctctggaagt actaagtcct acccagatgaaattcttcct
31561 tcagaagccc ttttccttca gtcttttttt tttttttttt ttttttgaggtggagtctta
31621 ctctgtcacc caggctggag tgcaatggtg ccatctgggc tcactgcaacctctgcctcc
31681 caggttcaag cgattctcct gcctcagcct cccaagtagc tgagattacaggcatgcacc
31741 accacacctg gctaattttt gtattttagt agagaccgtg tttcaccatgttggccaggc
31801 tggtatcaaa ctcctaacct caaatcatct gcccactttg gcctcccaaaatgctgtgtt
31861 tgcaggtatg agccactgcc cccagccccc tttccttcaa tctaatagctcacaagttca
31921 ataccatagt caggagagga gtgtagctcc caaaccctca aaatcctcatctcgtcttgc
31981 tgtgttctca gcatatcacc ccaaatggag gaaaggacat aaccacaaaaatgaggagac
32041 aatgaaaaat gaaattaggg aagagaagat gcagtgaaag agacacgtgaaatccacagg
32101 ccgaggcaga agaggaaagt gatggcggcg aaggggaggg aggtggcatgacaaggagac
32161 aaggcagttg cagacctgca cagagttccc actgggaaga tctaaactaaacacattctg
32221 ccgtgctgtg tcacttacga ctgctgtcac ctgtgagatc ccatttgattctctcaatag
32281 ccctctaagg tagatattgt cacccccctc ttttcacaga tggggaagctgaggcacagc
32341 tagtgagtgg cagagccagg gctagaactc aagtctcctg actcaaactcagagtttctg
32401 caacaccacg gagactccca gtctgcgtga gatacaagcc tcggtgttgtcagaagaaca
32461 aaaaagaagc aaagggtggg catgtccttt ggagctctgt gaggtgcccagagctcacag
32521 aggctgcctc agcaaaggaa ggtgtcagca atgggagatg gggctggaaatgctgtctgg
32581 gcacagcaag ggggcctctg ggtgctagga aggggaatcc ccacctctttcagggagctg
32641 tagaggagcc actgaaaagt tttaacaaag gagagataaa aagagaggaaaattcaaccc
32701 caaaagtctc cttcttacag cccatgcctc tacttccagg gaggccaaatgggagtaacc
32761 cccagtccca gaccctgagt cacttccctc cagccaagag gcccgtcaccctccgaggcc
32821 ccacactgat gccaggaccc cacctagagg tgccggcttg atcggtctccaggctgggcc
32881 ttgggatttt taaaagcttc tggaatggat tgcagttcca gccaagatgaagaacccctg
32941 agaaagacag agggagacag agacaaaggg agagatagag acagagagagaaactgatga
33001 aagaaaacag atgtggtgag gagaagaaag cagacgaatg atgcgggagggaaggaaaag
33061 aaatgagggg aaagcctcgt gtgggtggaa aatgcgggag ggagacaggggaggaaagaa
33121 aggaaactgt aaggtgggag caagtcagag accgaagaag ctgctgtgactcagtgagga
33181 ccctgtcttc tccctcaccc ggaaagcctc caagaagaac attccccgctgacataggca
33241 tggactgccc agacccggct gacgaatttc tgaaagggca cctgagccacacacctacac
33301 acgcttcccc tgattattct catctgcagt caggggcccc ggaagccccctgtctcctgt
33361 gccctccctg tcccccgact ctcactcaac aaactggccc tcgccccgcagccaggcagc
33421 ctccctcccc aggtccctta gcctcagcct cccgccaccg ttcaacaccccacctccctt
33481 tcacagggcc atctccaaag tcatgtcctt tttctcctga tctttctctccttccaatgc
33541 caaaatccca cccacagacc ctcaggggga ccaatcaccc ctcccctcttcatccccagt
33601 aaaccaaatc tcggtggctc ctgcggcccc ccgactccca cacagcgccctggctgatga
33661 gctgggcctt cctgggctgc tttatttccc tgcagcccca taaaagcagcttcattaaga
33721 aaaccacaca ctctgctgag ctgccagagg catccagaag ctggagccgcagccgctgaa
33781 tgaggcctgt gggccgggct gcctccactt cctgggactc tcagcgcacccctccgccct
33841 gtgcccacct cgcctctgaa gccctcccta ggccctgctc agaaccctccccaccccacc
33901 ccgcagaccc ctctcccgct cctctgcttc ttcctccctc tcatgccaaggccaggtcct
33961 cccttgccag tcctgaaggg agatgtcaca aaggccgttt tcctgagacaggccctgccc
34021 acactgggca gtgacccgcg gtgctggccc agtgtgccca agccctccaagtccccaggc
34081 tgggagaagg aatctcagct ttgggaatgg caaacgtgca gggtgggctcacagaagcct
34141 cctcccgagg gcctgctcag ccagcaacag agtgctccaa gtcatgcatctgctctgagg
34201 ccgagttcct tgtttataga gcacagaagc cattacccac ctctccggccattggaaaga
34261 ctaaatgaat gaatatgcac gtagagcatt cagacctctg cataagaaaaagttccccag
34321 aaatggcagc gattattact attattattt attactggac tattgagcagtctgaatttg
34381 gtagggtata aaaatggaac taaaaaataa aaagtcactg ccttctaccagatctgtcaa
34441 aatcctccct gacacggtct ctccacagcg tcttgagcag acctcagcgttgtctggtcc
34501 tgtccagaag ggcttcctac tccagtctgg catcctgttc acccctggccatcctccttc
34561 cctcatgctt gtggctcagg atgtggagtg ggacagggac ccctgctgaggccctccaca
34621 tcctcccctg gtgggcagcc catggaaaaa ctgtcctcat atcactctaccccacttggc
34681 caatggagcg caaatagatg acttgccaca gccaacagtg gcaggctgggctccttgccc
34741 tgctgtactc tatgggtctc ctgccagtcc actgccctgc agatgccactggggatttgc
34801 atgccatgct gcccctcttg caggtatcta atcaccatga gctgtttccccaagaagtac
34861 cacaaaaaca ctacgcctag gacagaattc ttcccacctt tcccttgcccagtcttcttt
34921 cccatcccag gaaggtgggc tgggtgatgg ttggaggtaa cagggcctttgaggaagccc
34981 taggaagatg tctggctctg cccattggca gctttttaca gaatggggcactgggccact
35041 ttagcctctg ttttgagcca ttgttgccac ttctagggca ccaggaaaaatcccaatcaa
35101 attcctactc atcattaaca ttgagttagg gaggaagcaa cgaagaagtggtaagggtga
35161 atctagaaac aatgagttgg ggacaggctg tgggcctgac cccaataacactaatcagct
35221 caaacctgtc cccagtgtta ccactggcag agtgaggagt ggtttgaactcaacacagga
35281 gtctggggca gagcctgtgc cagtcagggt gattctgatg agagagagctggaagctcac
35341 agctccattc agcacccacc aaaaaccagg ctcacaccca cattccttgctgtctccctg
35401 ggacccgacc accaccctgg ttgcaccacc ctctcccaac ccccctcaggagctgggagg
35461 ccatggaagc agcgctgtgt agggagtcaa aagtcctggt aggtccaggctcttcaccta
35521 ccacatgacc ttgggcaggt cctccaacat ctctgagcac catctttgaaagaggagtgg
35581 gcaacaatgc cggctctaca aggtggttgt tggaactaaa tgagattccaggtgtcaatg
35641 ctttgtccct ggggagcact gggcccaagt gaggggccac tctgactgttggagatcccc
35701 acaagagatt cccctcccac accccacggc tcctacctgt tattgccaccgaagccgcag
35761 ttgtccctct ctccccagac atttcggtgg ccggtggcca gcagcatcgacagaaatgag
35821 atgctggaga ttcaggtttt caactacagc aaagtcttca gcaacaagtaagtgtgggat
35881 ggggcaggag gggctgggcc tggacgggct gggagcctgc tcttctccttgggctaccct
35941 ctgtttgggg cttaaaaagg ggacctacac tcccaacctg ccctggattgatcttcaaag
36001 accgaagaaa tcttgggctg gtctttgatc cccattttga tccctcttcttgtcttcaga
36061 atcccccagt tctcccagct gctgtcagcc aagaacactc caccctcctatcacctctgc
36121 tgtctccaac cccatcaaag cttcctgtct taaagactta aagctttaagtctccctcaa
36181 tgccacgctg gggtacagtt acccactgga gaggcgaaag gtggaggggctgatgatctc
36241 ctccaagaga cactctgtag ccctgagggc aggcttgaca gtttggggtggtggtttagg
36301 agtcaggcaa gcctgatctc agacactcag gtcagtcatc tactgtgtgaccctggaaag
36361 gttacataac ctctctgatt tcaatgtgct catgtgtgaa aaggacaagtatttacctca
36421 aagggcagct gtgtgaatta aatgagatag atattcactc actcattcaacaaatgttta
36481 ctaagcgtcg attgtgtatc aggtactgaa ttaggtgatg cagagggcggggtgcctacc
36541 ttcatggagc ttgcactcca caagtgaagt acacctgcca tacgagcgttatcactataa
36601 ggtgttcaat aaaagtagtt gtcatccttc tctctgggcc atgagaagaattcagaagga
36661 tttgaacacg ctggaacagt ggctaagtaa tatcttgggt taaaaaatcacagccaggtg
36721 tggcacacac ctgtagtcct aggtccttgg gcagataagg cgggaggatcatttgatccc
36781 agtaatttga ggctagcctg ggcaacatag tgagatccca tctctttaaaaaaaaatcgg
36841 ttgctcttat acaagctgga ggtcatggct taactgtaac atgtccaagaaggtatggag
36901 gtgttagctc actgaggact cagaatgact caacagtggg aggagactacaaacaaaaga
36961 aaagtaggcc tcatcctaaa tcatactaat agaattaaag cactcctgatctgagcagga
37021 gagacaagga gtccactgct ctgatactag tggcagagaa ttcctgtaggcaccacccta
37081 tagtttccag gaggaaaggg actttaagtg ttaccttata acaaatggatgagagcctga
37141 aagggaaaat catagaggac atattcatcc attcatccat ccattgatccattcatccat
37201 ccatccatct atcattcctg ttattcatcc atctgcctat ccatttgtctgtccatcaat
37261 tgatttatcc acccttcctt tctttcatcc atccttccat cctttcatccatccattcat
37321 caatccatcc ctccatccat ttatcaattc atttatccac ccatttatccatctatccat
37381 tcatccgtcc atcctttcat tcatcctatc catccactca tccatccatccatccatcca
37441 ttcacccatc cttcctttca tccattcatt catcaaccca atccttccatctttccatcc
37501 attcatccac cacttaccct ttcatccttt ccattcatcc ttccatccactcatccatcc
37561 attcatccat ccttccacct tttttctttt cctttttttt ttttttttttttgagacaga
37621 gtcttgctct gtggcccaca gtggagtgca gtggcctgat ctcggctcactgcaacctcc
37681 gcctctctgg ttcaagcaat tatcctgtat cagcctcctg agtagctgggattagaggtg
37741 ctcaccaccg tgcccagcta atttttgtat ttttagtaga gatggggtttcaccatgttg
37801 gccaggttgg tatcgaactc ctgacctcaa gtgatctacc ctcctcggcctcccaaagtg
37861 ctgggattac aggcgtgagc caccactttt ggcccatcct tctatctttccattcactga
37921 tccatctatc gatccatcca ttctttcatt ctttcatcca tccttccatccatcatcctt
37981 ccttccatcc attcatccat cctttcattc ttccatccat tcatccatccatccatcttt
38041 tcacccaact ttgcagtcac tcatcataca tatagtgaac aaatgctttctgccagtcag
38101 acactatgct agtcactgga gatactgaga tgaggtattg aggcacagtccctgccccta
38161 ccctcccaga aggctttttg ccacaggaag aggaaagaaa ggtgtgtacctagaggcagg
38221 atgaggaaca ggctgctgga agacagcaga caactgaaag atagccagtattttccagcc
38281 aatgtgctgt cttaggaggt agtgagctcc ttgccactgg gagagggtgagcaaagagtg
38341 gaccacattg tagaggggat ttctgagtca ggaaaggccc caccatatgggctccaagga
38401 gtctctgatt ctgtgggttt tattaggagc tttcaaaatc tcagctgagtatggggcaag
38461 ggcatttcag aaatgctgtc agggccacag ggaggatgtt tagtgcacaaaggccttccc
38521 tttgcctctc atggcatcac accattcagg cagctgcttt tggcacccacaagcaaggtt
38581 ggtgagacac cccccaccag gggcccccaa ggtgaagcag agccttcttccctggggtga
38641 gataccatga gggtgtgacc tatgaggaca ggagaaacag gaacaagtggaaggctcaca
38701 cacagaccaa gtgggtgtga aaaaggaagg agaatcggaa gtcaagcaccagggagggca
38761 cctgagagcc cctgaaggaa cccaaccata ggtgccaaag catccaggagctttacagct
38821 cagccactac agccctagct gtgcaggagg ggaaaccaag tctcagaggggaacctgagg
38881 tcacatgggt agacaatggt agagccaggg ctagaatgca tgtctgttaacttctcttcc
38941 taatccaact cccagaaacc aaaatatttg agcagtgatg gtggaaactgagggcatgga
39001 agacattgtt aaatcattta taatgaaagc caccagccta accactgaaatgctggaaac
39061 acttgagccc atcaaaagac tgctacaaac aaatcagaag tatttgggaaatcgggaaat
39121 tgactcccat gcagtgaata tgttgaaagt tacagcttct attaggtgtttttggttttt
39181 gttttgttca gagacagaat ctcactctgt cacccaggct ggagtgcagtggcctagtct
39241 cggctcattg caacctctgc ctcctgagtt caagtgattc tcatgtcttggcctcccgag
39301 tagctgggac tacaggtgca tgccaccagg cctggataat ttttgtatttttagtagaga
39361 cagggttttc cccatgttgg ccaggatggt ctcgaactcc tggcttcaggtaatagacct
39421 gcctcagctt cccaaagtgc tgggattaca ggtgccagcc accaaatccagcctgtatta
39481 gatgttctta agtgccaata agaaggaaga cagaaagggg aatagttcctatcctaactc
39541 tcctcttctt ccctccctgc ccccatccaa gagaaggcag gaaaccccacaaggggaggc
39601 ccaggcctgg tgggagaggt tctggcattt ctttggaagc ctagagaatgcccagggcac
39661 tgctggctgc agagctgaga tgggaaagaa gaggtcccct tgtggagagcacaggcccag
39721 gctgacacag gccagcttgt gggggtcaga gtgggagaga ggtgtttggaatgatgtgag
39781 actcaagtct ccccatcctg gcatttgcct gggccaggcc agaggagcaatgaggccact
39841 gccctcaacc cccacatggc ccagttcaga ccccaggctc cttctcatggggcagctgag
39901 tggaaggggt ctttggggtc tgcactaggc ttagcaatga gcaaagccatggccactgct
39961 ggggacagtg cctggcacat ggcaggctcc tgattatttt gtggaataaaagaatgaata
40021 aatgcccctg tggtgttagg aggcagaggg taggtataca aggtgggagagcctttgaga
40081 gggaatcgga gtggcccctc ttctctgaag gactcagggc actcaagggtgacactcagc
40141 atcacatgac cgatgcattt ggggaaattg agctaaaaga ggcatggaggagctgcctgg
40201 gagagtgggt cccaggacga gaaatgagcc tgatcccatc actgccatctcagagagaga
40261 gacttgtcct agaagcagag agtagcttgg aaactggccc ctcacccagtggttctagag
40321 gctgccagga ggcagagaca tggtatgaag gaaggaggca tcctaggcagaaaccaggag
40381 acctccaggt ctgcttggcc ccgtttggaa caaagacctg tgtccaggaaccttgggctt
40441 ccccatgaga aagaaatgtt cggttcagaa gattttgtgc atccagctctgcctgtccgg
40501 gacctctgag ggtccatggc ctggcctcca gcctcctgcc tgctaaggatgccagggacc
40561 ctgaataatt caggagccag gacagcagga gaggcctcgc agggcccaggacacctgaca
40621 cgggctccca ggggaaagtg atgaattatt gacaggattc tggtgcccagttgccgctct
40681 attgtgatca gtctgtgggc ccatctgggc tggaggcctt ttcctgccggctaattacgt
40741 ggggatctta gctctgccca gccgcccagc ccctcgtggg gccagacagcctcctgtgag
40801 gggtgtcctc tttgccatgg tgacctggat ggccctgtaa ggcaagtagtcagaggacat
40861 ggagttagcc ccagatcctt tgcctgacag ccccagggaa actgaggcccagagaggcct
40921 cttgtccagg gtcacacagc aggttcagga cagtcaggtc ttcaccccaggcctcctgac
40981 acccgggcca gtgctccttc ccacagaaca catggcctca caactccatttctagggaaa
41041 tgactcagct gtctaaggag catatgagcc cacccttcct caatcgtcctgggccccact
41101 ctcccaggca gctcctccat gctgacccat gcagaggagt aagaacctactatgtgtgca
41161 gccaggatgc acaaaggcca gctgcggcgg gcagggtcgc ctctggggtcaccacaaggg
41221 ccagagccag gggcttctcc tacctcttcc tgtcccagct tcttcccaaagaatatctat
41281 agaagacggg ctgagggatg gcatcctaga agcagtgcca gggcctttgttttgaaactg
41341 ttttcatggc aagcactgtg tttttgctta aatggtatgt tacagacctgtagaaagagt
41401 caaggtttat aaaactgctt ttctttatac tttacataag gctgagataatatcaattgt
41461 ccatgtcaaa aaatataatt tttactttta tttgagagag gttggggggtgaactgttag
41521 gagttaaaac cccccaagcc actcttggag gtgtggcaaa ttgattcctttaatcttgca
41581 agctcctagc gtcccagtcc caccctccag gccatagaca agctctggctgtgcgaggct
41641 gtgcacagct tgaagggtgg gggactgcct ggacctgccc ctgaagcccatcctgcaaag
41701 gagactcgcc ctgtgtaggc tctccagatg gccagccctg ctcattattagggagggagg
41761 aggggctggc atccgagtgc cggtgttggt agaggaattt cacatgagcagtctcctcac
41821 cactgtccgg tggaagtcgg agggctatag cagaaggagc caaaaccacactgctgccag
41881 gaggtggaat ctcccttggg tcctgctgag tgagcccaca tctgtctgactccagagccc
41941 aggctcctca ctgtctacac cgcttccctt tagggatgga attaatctgcatgtggacag
42001 ggcttggacc agggtaggaa gagtagggga tttgcctgga ggccaatcttgctcagcaca
42061 ctgtgtgatt aaggcagtgg ctgaatggac taccagtgac agccccatcactgtcaccac
42121 caccggagta tctagcaggg acttaaaagc acatgtcagg gaggttgtttcagggattcc
42181 tcctggaagg ggcgctggac aaggtctctc aggttcttcc caagtataagatctgagatt
42241 caggcaggtt aagcctagaa ggcaccagac gcctctgtga gcacttgcagggggaatagc
42301 tccaccctgc cccctgggag tgtcttgtca cattgcagca cctctgcggatcctggggag
42361 ctgccttggc tgttcttagg catctaattc tggagaaaga tgtgcctgatcgccccacgc
42421 tcaacaggtg ctcgacaggt cctaggggaa tcaaggcagc tgaatagccatccacaaagg
42481 gtaatagtag agcagggatt ctcaaagtgt ctccccagcc agcagcttcagcatcacctg
42541 gaaacttgtc agaaatacac attctcaggc cctctcccac ccactgaatcagagccctgg
42601 ggtcggggcc agtggtgtga actgaagtcc ggtggaccca gtttggtgacttcacattag
42661 aagcttgaag ttggccatgg cgggagtatt tatatctcag aaaccagcaaatgctacaga
42721 tgagcacctc tcctctccca ccagtgacac attttccagc atatccacagaagaggatat
42781 cccagccgtg catgttttca caagccctcc aggtgattct gctcatgctgaagtttgaga
42841 accactgatt tagaacaaaa aggggtgagg ctgcaaaaag atgagtgtattttttcgtgc
42901 ccgtggtcta ctgttagaat gtctacatgg tacggaagct aaaagtccccttccctcttc
42961 attttataaa gaccaaattg agactcaggg gcagcagctc cagggctcctggcccccagc
43021 ccagcacttc tgtctctggg gcactgcctg agctgggaga ggtgcatgcagctatggaag
43081 aaggcttcca tgggctgctc taagggccca gaagcccagt tcggctttagagtgaaggag
43141 tggcgtggtc agtttcatcc tcagggaggt ggggcacaat ggtggttggggctctgagct
43201 ccaaagggga gcatttcata tccattcctc atggctgccc ctaccacttcctcccctcac
43261 acagatggga agatttttaa aaaatcaatg ttcaccctcc acagacctcagggtggtaga
43321 gacatgaagc atgtctgagt cagaattcat ctgatacctc acctcacccagatctaccat
43381 taattagctg tgtcccttcc ccttccatgg cctcactgtc ttcctctataaatctcaggc
43441 agcatcagat gatgcccaag gtcccttcca gctctcacac gccctggatgcttccctccc
43501 ctttgtgcct tcagctagaa atggtgtgtg tattctaatc cactctatgtggaagcacca
43561 tgtaagaacg tctgtctgag ttccctgttc tctcccagag caacaaacagccttctgact
43621 gtggggtgca atggggttga agtcaactcc atcagcattt attgggcacccactgttgtt
43681 cattaattca gccagcagat attgagatct ctagtgtgct agaaatgtcaaacagaggct
43741 agaataaaaa gcaccaccca tgcccttgag aggttcacag tttagaggcagtacatgaat
43801 cacgacaaaa cggactgctt tggagtgctg gctgtgtgct gggggctttgacaagaacac
43861 tcgcagatga tctcattcag tcctccaaca acaactctgt gaagtagggcttatcagctc
43921 atcttatgag aaaaccgaca ctgagagagc ttaaggaagt tgcccaggaagcaggtagct
43981 tgctagtcag tgtcagagct gggttcagat ccctgtctct ttgatgccaggactgtgctg
44041 ttaaccaaag cattgcaccg cctctcccct gctgtgcagt tccatgggctctgccatcac
44101 acaggttcct gccatccagg aacttacagg ctgcagatgt ggaatggatgagtgagtgct
44161 gttggtgtgg gctggaaacc ttggtcatgg ttaggcgggt agaagccggaggagctactt
44221 gtccatccag gaaactcagg tcctttccca gcctccacac tgagcatctggaagcttctc
44281 tgcaagggct cagctaaagc tggatttcat gcacctttcc ccgcagtctgtagacatccc
44341 ctaagggtgc tcactgcccc ttggagctct cccaaggaaa tgggcctcccacaaacaacc
44401 atccacagtg ggacatgctg ccctggctgc aaccagtcct ggctcctgggccaccttctc
44461 cagcccagcc cagagctgga gcaagcccac ctgagtcctc cccaagcagtcacagccctt
44521 gggatgtcag tcttgctcct caccctggtc tcttccatgt taccaccgtgccccctctgc
44581 catccccagg ctcatcggga ccttccgcat ggtgctgcag aaggtggtagaggagagcca
44641 tgtggaggtg actgacacgc tgattgatga caacaatgct atcatcaaggtgggtatgcc
44701 ccacggagtt cctggacttt cccatatggg gccatctggg ggtctgttctccctgcctca
44761 cacatggggt ggtctgggga atgcctctca tgcatggcga ggtgtcgcaggaggaggaga
44821 ctcaggtcag actctgctgg aatggctcaa tctgtggcca tggctggaggccctgtggca
44881 tggcagggtc tgctgcccca cagtaggcac ccctgccctt cctacggtgggaatgcacca
44941 actggtcctt ccatttggac ccagctcagg agtcactaaa gaggctccttttgtcatcca
45001 aaggccagac tgagccctgc tggcactcga gggcatgacc ttcactctgcacatctggct
45061 cgggtcctcc ctgggagggc agggacctca tttcctattg tttgtcacatcccagcactt
45121 ttgcgtgagc acgcgtgcac tagtgatgca cagtctagag gcacctgacacatgttctaa
45181 caaagaagga agcaacccta ccaggacagc ctggccccag gctctgctctgattcttcag
45241 tcctcttgag ctcagccgtg gccactcatg ggcagttggc atgatggtgaggaacaggga
45301 ccctgagtat gaatcttagg ctgctcacta actgtgtgac ttaggcaagctacatatcac
45361 ctcaaagtga gcacaattac attatccacc tcccaggact attctgaggattaaaggaca
45421 atacacagaa agtacttagc acagatatgc acaataaatc tataatattgttagctatta
45481 tttcctgacc tcagtttacc tatgtataaa atgggactgt gccatggtcccccagtgggg
45541 tcctgtgtaa tatatggccc tatgtagtgg ccaagagaaa cagcctcagaagccaggact
45601 gcagccacag ggagctagaa cagaaggaac cctcttctcc catgggcaggggtggcaggg
45661 agggcttctt aaagttaccg gggtctcagc caccacagca aggggagaaggggtgcagaa
45721 taagctatgt atggacaccc atgggaaggc gggctgggag gagaacacagaaacctggat
45781 gaagagtgta gtgtgggaag tgagataaga gaattgggga gtgagcagggatggacagac
45841 agcacagccc atgccctgga ttttcagaat cagacttaag atgtcagcagaggaaaggac
45901 tcacggatct cctagcccac ttgccaccca tctccgctac ccattgttatgaatgggaac
45961 aatgaagtcc tggatgggga atggattcgg ccacagttga cagcagggccagcacggaga
46021 cccaggactt ccaatgccag agaccaccat tttcccataa caacatacttggttccacca
46081 agagggtccc atttgttcca gaaaggacat ggggcttgga gttaggcagcctgggctcag
46141 atcccagctc cagtacttcc tagctgtgtg acttaaagca agtaacttaacctcctgata
46201 tgctaggtaa ggtaggttgc aatgttgaaa agatcaaatg agtgtacattaaagcatctt
46261 agcatgatgc ctagcacagt gaggattcag aaaatatgtg cacctttcccttcccttggg
46321 aaatctaagc ctgggtgctg gagcatccaa gcactgagtg agggccgcctgtctggggca
46381 caggaccaag tcacctctag accagtgagg aagggtgatc cctgtgcactgggggggaaa
46441 ctagagctgc aagaaagtaa tggctccagg acgcagagca ggaagcccaatcatgactct
46501 ccactgctaa gcctgagccc ggttgagtgc tctacttttt gccagaggaaaaccctaggg
46561 cagctcccaa gattccctcc ctctccaggg taggaagggt gagtgtgagcctgggccctg
46621 ggctcctctc ccggaggcca ctttcagctc attctgtcca tttccaacaagccgatttct
46681 ggcgggccgc gcctcatgcc tgcaggcagc ccttgttctg aggagaggaggtggcctgat
46741 catggggatg ctgaacgaca ctctcggtta tgtagacagt ggactcggggggtgagtcca
46801 ggctcagttg tcctgggcag gccaggcccc tccaccttga gcaccagggaggagtggaac
46861 caccagcagc gggacctgga gccaggtacc agtaagctga cccggtctgcacaagtcagc
46921 ctttcagagc ctctgttttc tcatcagcaa aatggggcag aggggatcataccatcctga
46981 cctcctccag tgaggcaagg gtgtggaagc gctgtgtaaa caccaccaagcagccacata
47041 tacggggtgg agattgctgt caccatccca gctgctcacc accgcctccctcccttcaga
47101 ccagcctgtg cgtggaggtc cggtatcagg ccactgacgg cacagtgggctcctgggacg
47161 atggggactt cctgggagat gagtctcttc aagaggaaga gaaggacagccaagagacgg
47221 atggactgct cccaggctcc cggcccagct cccggccccc aggagagaagagcttccgga
47281 ggtaacaggc aggacccctc tggctgccca ctgctcccaa gacacggggaagagacctgg
47341 ggcctggtcc tactgacagg cctctctagg cctagctggg ctcagagtacagggctgagc
47401 ttctggagag acatccaagg ggtgggaaga tgtttctgta gccccccacccagccgtcca
47461 cccccgaggt cactgggcag ggagcaggag actcagatgg agctgcaaggccaaggcctc
47521 cccagtggcc ctgagggagg tggagctcta acacagggat ggggctagatctcctgcctt
47581 tctcagagaa ggggagttgg ggataggagg gcccctggcc tctctggttcaagacccagc
47641 agtgtccacc aggtgccggc agcctgacct ctaccctggc ccagtgaggaggcccaagag
47701 agggcagctc ttcctgccag agtgaagcca aagatcctgg ctgggccctggcctttcttc
47761 ctcttgagaa gggagggtac ccgggaaccc ccagaatcca gcgtcacgccctgcaagtgt
47821 cctgccacct atggatcaca ggaagctgga tccaggacag ctcattccacgtgcactatt
47881 tttacaaaac agaaaatgca attgtattac tattagagac caaggggacagaatctgggc
47941 tagtctagta agatgttgtc catgggttcc taagtcacta ggaattatgtgttaaatgcc
48001 agtaagtcaa gggtgcatct gaaggaccag ggtgtgtttt gagaagggaccctccgtgcc
48061 actggaaaca tatccctgta agctccttcc acgctttcct ttccaagtaaagtttactca
48121 gtccctctgc tgaagaaacc ataggttcta aattagtgta attgaactgacatactttta
48181 tgggacaaat atgttttctc ctttgcactt gaatgagttc acacccccttaagcacccct
48241 cacacacagg tgcatgagtg cacacgtgtg cacatacaca tacacacacacacacaagct
48301 tcagaaaccc tgggagccag atgagtaata gtaacaaggt caaagtgaccaggcctgcaa
48361 caaacatggc gggactgtct actccaggcc agccacgggc atggggcagccccaggctag
48421 cttaaagcct gtcccctcag actcctggct ctttagcaga aaacccaggcctgagtccta
48481 gctctgcctc ttactagtcg tgtgaccctt ggcaagtctc tgaccctctctcctcacctg
48541 caaagaagga catagcaagg aaatccccct gccctgctgc tgggagagccggagggatca
48601 cagaggaaca ggtggcaatg gaggtgctga gcgctgccca tgtccaggctggtgacagac
48661 aaacaggttt cttgtagcac aacaatgcaa agagtcagga atcgggttggaaattgtgag
48721 aagaggagca gtgctcagac ggggagtgaa gggatgctga ctcagtgggcaccacctggt
48781 cctcctcgac tgtctccatt cagaaaagag gttggcaggg ctggtccagaaaccagaagc
48841 cgggctctaa gaaagagctt ccagagaaca agatcggaag ccacacaagggccatcagtc
48901 acagggaaag gaatgctgac cccaaatcag gagagctaag gcccattaagtcccatcttg
48961 actgtgccac tcattggctg agtgacactg ggcatgtcac cagcccctgtaggtcagtga
49021 caggaatggg ttcagcaagt tacatctggc tcccctccaa ctctgaggtcctaagggacc
49081 catggatgct ccggacctgt gggtcacatc catgggaaac aacatcctgggagcccttag
49141 cagccacgaa ggcaacctcc ctggggtggc gtagcaacac agagccagtttctcactcag
49201 tcctaagaga gtgggccagg gtgctgatgg gggctctgga gagcttagagtcccagagag
49261 ccctaggcac caggaatctg gagataagag ggctcccccg acccttcctcacagcctggt
49321 ggcttcccca cctctcccca tcttcgtgtg gcccctccca gggtagcagcaagaagcggg
49381 agcaaaagga ggggcttcac cccggactgg gaattgggag agggtgacagccgaagccag
49441 gcacccccac cctgcattgc aggggcagtg tgcaggagca cagtttccctgctgccactg
49501 gggctgccag cccaggtttg agagcacatt ggggacaggc atcgctgctacaccttctcc
49561 cgccaggcct agccatgcag ccagcaggcc tggttgtgga aaagaggggttgagaaaaat
49621 tctagagatg ggccatttgc tggtgaggag aaggtggagc gggttcaagaacttggggtt
49681 ttcctgtagc ttaatcctgg ctgcccatat ggggccattg agttctgggtcaaggagtgc
49741 tgaggtgagg agggggacct ggaagctggc cccgcagccc tagatgttgcatctcaccct
49801 tgtcacatag tgtgggttct gggaggaagc cagagagctc tccagaagggacttggccaa
49861 ccttttatca ggaaaacacc tactccttaa agaggacaac accggggaaggggtgtcagt
49921 gcctcacctc tgaccccgtt aggagcccag gcaggcttcc cctgcatctgctccctgccc
49981 tccatcctct cctgggaagg ccaatcccct tatagatcag ggtattcaataaccacagtt
50041 ccctcttgtt cctgctttag ccacaatgag caagaggaaa atcccgttgctggcaagcag
50101 cagtgtctca ccggccatct tgaccgttag ggtccggcgt ggggatcagccgctccctgg
50161 ctgatggggt gaaatgaagg cctgctgggg gctgcgggga ggtagactgagtgggcagga
50221 aacagcctca gcccagacag gccccgggca gcccaggctg gaatcttccacggatggagg
50281 ggaggctgat gccaggagat cctctgggca ctcctcacct ctccctccagggcctgggtc
50341 caccccccag ccctgccctg cctggcctgc ttctctggga cttcacccacattcatcctg
50401 tcctcactct gggggtcaga tggttctaag caggggcagt gtggacctcaggcctcagct
50461 gctgtgacac tcactcctaa gaccctaaga atctgccatg aagttaccccgttcctcctc
50521 agggaatcag tatgggggct ctgcctgaat gaccaccaac cccaccgcccactgactctc
50581 tgccccaacg attccacctc ccctaggccc tggtcagccg catgccctctgagccactct
50641 gcccacttct ctagttcctg ccacgaagcc ctgatttctg ccggctttttgcacaatgcc
50701 cccggtaatg tgccaggaag ctgtgctgtg tgacagagca caggctccactcacagctct
50761 gctattggga acccccctcc ccatttgtga gatggggctc aaggatgcctcacagaagtg
50821 ccaggattga gtgaggtgca cctgcgagtc atccacccct gtgcctggcatgtggcaggt
50881 gctcagccag tgttcacttc cttcctcttc actgactcca tgttaccctgatgtcaactt
50941 ctaccccgag cagcacctga ccctcttgtt caggtgctgt ccaagcaccttctcagctct
51001 tgctccccac cctataccaa gggctctgca gaagctgccc acacaggagccttactggcc
51061 caggggcagg tatagggagc tcatttactc aaagttcccc tcacctccccaggctctcag
51121 tgttgcagag atgtaatgaa tccctaacct catgggcgct ccactctcagcagcacaaaa
51181 tcagtgttcc agacccttgc atggcagcgt atgcctgccc tagtctctggagagaaagtg
51241 acttcggccc tgaccacact cacatgcaca cacatgtgta cacaagtgcccatgtgtttg
51301 cacacactca catgcactgc atgacaccag ggaggactct ggattctgggctctgctgtt
51361 gatgctgtct ttaggagtca catcttagag aggacaaaga aagaaatcccagctttagtc
51421 ttgcagctaa actgtagaga cctgagcctt tcctcctgag tcccagtattctgcgactat
51481 ctcctcttct cattttctcc acctggcctg gctctcctgc cctccacgacccccacctcc
51541 ttctgctgcc caaaccctct tctgctggtc tcctctctgc tgggtctcatctgggaggag
51601 tttggggcag gagccacttt tctcattctc cttattgatc attcttccactccagtggag
51661 gcctgcagaa gccaggtaac ttcctcctat gctggggcca gagggcagtggggcacgtgt
51721 gcatggtggg gctctgagac agaggggcag agagtgggca tgcagaagtgtgtgcatgtg
51781 gggccagtac atgcagcctt accccaagag tgtttttaaa tcggtttccacagcccctag
51841 agagctagaa aatcctctgc tgccttcctt ctccaggctg agccccagagttgcagcagc
51901 tcccaaagct gctcagatga gccggggcag ccgggcgcac tgggattttgtgcttgagac
51961 acattcctcc tcctatgctg tgagctcttc tccgcttagt agtctcagctgatgtgggca
52021 gccgaggcct ggctgatgtt aacacctttg aattacagac tgacctgcttgcccaacgta
52081 aaggttagct ggccagcgct ggactgcagc tgtgctgtgt ctaggccttcaggtcttgag
52141 ccatcaggat atgcagtcaa gtctacctgg gcaaggcctg tgccagaacagggtgtgagg
52201 agaggaataa tttgctaatt gttattcact ttcctgtctt catcctcattgccacagcac
52261 tgggaaagca ttgagagaac attccagaaa agttttctgg aagcctccctaaagtgagat
52321 aggggggccg tttttccctg ctctgagccc tggagtggta gctcacttaccgccccacct
52381 acacccctag aactgccccc aaccacccgt gtgcactcca tagcaggacccccagccctg
52441 cctcaccctc acagagcagg cttagcccac tgttccccta gaggcccccagagcctggga
52501 gctcccaccc cattggaggg gagcagggga gcaggggagc cggtgggcagaggagcaggg
52561 tggcccaggc cgggagggtg gccaggctca tctaaccctg tgttccctgaggaagctgcg
52621 acccacattg tggaatcatc agatcttagc ctggtagggg cgatgagctgaggccctgag
52681 gtatcagagc ttggggttgg aatagtggcc acccaggccc agcactgtgggcccctccca
52741 tctcccccaa ggcagaaccc agggccatgg gacccctttt ctgcagacctaggcttgcta
52801 ccgtgcgaag ctgtggggtg agaggtctgt gggacaagga ggcccccggggagcgtgcag
52861 gcccgtgggg ccggggctga ggccagtgtc tctggtccac agcccctcacacgtgtcccc
52921 ttgtctcctc atttcttccc cctactcagc aaaggcagag agaagaccaagggaggcaga
52981 gatgacgagc acaagtaggt gtcccaggcg agggcagacg caacagcgtctctggggaga
53041 cagaggcctc ctccccacag gctgtggagg gcgggatggg ctcggctgagagggctcagg
53101 agtgggctgt cgtggtagag ctggcacggg tcatggaggc ccagggaggccttttcacct
53161 ggccacgggg gtgagggatg aggaggggtt agggtcgcgg gggaggtggccagaccttct
53221 ggtttccact ctgggctctc gggggtgacc atcctcctct ccgtgtcttgttcctcctcc
53281 actgttcagc ccccatcctg tggccttcgg gcttccctgg gagggaggggacagctaaag
53341 gctaagggga gaggggcatg aggacctcag ggatccctct cccaacaggggcgaggtagg
53401 gccaggcagc tggaggcata aggaggagga actctgggta ccctttgcagctgcaggtcg
53461 tgggtggagt tggagacccc cagaaagctt aggagaggcc accatttgggcggccctctc
53521 tatcttcatc tccccaaaag gcttcctgga aaaatgaggt cagggtgctgtctggagagg
53581 acaggagaag ggtcctgcag gtgggagggg ctggtcacaa gggtctggaaagattcgaag
53641 gctgggagtt gtgaatgggt cttgtaggca cccctagaag cacactgacatctggaggac
53701 tctagcatta cgggatctca taagggcagt ggtagccaag gtggaccatactggaggagg
53761 cctctggtta acacctgctc ttacagatga caaatctgtc tcagaacaggggcagagctg
53821 gaaccagaag acagggaagc tgacttctga cccagagctc accatagacccaggaaattt
53881 agagaacttg actgtatcta aatttaatct aattctccaa acataccaatgagagctgaa
53941 aagccaggag tgtggtcttt tttatcttcc agataagcaa cctgagccccagagatctta
54001 agagatttgc tcaaaactgt ggcctcaata tattaagaat tagttcatctgaagatatca
54061 tggaaatatc aggattgtgt gttgaggggt ctgaactgat caacactggtgtgggcttgg
54121 gatatccact ggcattaaga tcctggggaa ctcacagcct cattcattgcttcaaaaaaa
54181 ggtatgagtt ctaactcgca tttgttacgc acaagcaaaa gcaatgatgatgcagtgtta
54241 actctgtagt gatggaggaa atggcgctgt gtaggaagag ctccagcccagagacctgaa
54301 ggatggagga gtttgccagg ttcccagtaa gggaagacac gtaggcagagcatgtgtcaa
54361 ggctcagagc cagggaactg aatccagggt gggtggcgat gatggggaatgctgagctgg
54421 ggagtcctct tagggagtcc tcaagggttc aggtttctcc atagatgcttagatgtaaag
54481 ggcatatgaa tgagatacaa gcagcctgtc catccccagc ttctctgcctgagatcagcg
54541 atgctctaag gcccttcttg atgcccagct tcccagtctg tcccaggccagacccacagg
54601 gacacagact ggcctgatcc ctttgactgg ctacagttgg agtaagaggtacctcacagt
54661 gccagcacat agtaggtcca ccaaaatact ggtttcctag cacttctctgtcctaatttc
54721 ttaccatctc taattagcac atgagataaa gtaaactggc atatagtattgttattatta
54781 ttatgtgtag agcaatagga ctattgaaag aataggaaaa tgagatttctaagaagagat
54841 tgaacaaatt taaactcttt agcctggagg agagaaaact gtggagacagatttcaatct
54901 ctgaaatgtt aatgtgtggc aaagctggtt ggtatctatc tccactgagaagagataaat
54961 ggaaataaat ttaagttgaa gttaagttga agtagagaaa caagattcaacccacgaaag
55021 aactcatagt gtgtgacatt ctgggatagg ctggtttggg gagatgagaaaacacccatc
55081 atcttccatg atgctgcttg cttgagcctt gcaaagggct gggccgccagcaagaactga
55141 agagccagct tccctgacaa tcctggggtc aggacaagtg tgtgtgggtcccccaagcct
55201 tctggtacaa cgtgggcaca tgtgcaaacg ggccagtttg gagacagggtggttcttgta
55261 taaagggtca gcctatcctg cccacctatg gaaagctatt caaaaactaactgacattca
55321 acacactttc aaagacacct gtaaagacca aaattatgaa attccctgtgccttggggca
55381 tggaaaattt ttaaaataaa cccatttagg ggcgcttgga taacatgctccgaggttttg
55441 aaaattgggc tgtttgagca atgcaaagaa ggaccacaga ccctatttctcatagacagg
55501 agtctttatc ctgattgatt acctgaggcc tgagctaatg agcctagtagttccagttga
55561 agccagtcat ggggcagaag ccctgggcag tgaatggact cgacctgcagctcatttatg
55621 gtcaggtctc tattagcttt cagaataatc cagagacctg aattaatgaaacactcgggt
55681 cactaaattt agtttggtga atgttcccaa gtcattatga atactaagctctacctagga
55741 ccctgtgtgc accacacagc aacacgcttc taaatctggg ccataaaatgagcggagaaa
55801 tcatcagatt tatagtttac aataagtgaa ctaattttag catttttttcctctagagat
55861 aaataccagt ctagattgta ggtgcatttc attctgacca tggtgaatgtagccacagga
55921 aactcaaacg gattctaaat cctcagaggg tcctgggata ctggcctccccttggctctc
55981 acttctcaag ctttaatacg cccaagaata aggagccatt tgattgtaaagtgagttttc
56041 actgagttga ttattggctt gttttctttg tctgtttctc accatatcctgtttttggta
56101 attgtagaac tcaactagac caaatgcaga attttacttt gaaaacaaaaaaaggccagg
56161 acaacggaca cctcaacagc aaattacatt ttttgaaatc taagtctttcagacaaatag
56221 ataatcttca aaattccctg attaagttga catttatttc aaaactctcctttacagttt
56281 gccaagagaa gtaggcatac tgctttctgg gaactggtgc tgcaatcaggcagaaaggct
56341 ttttctatag tgaacttctg atgtgttact gatcagaaaa ttacaaaggctagtggcagt
56401 gatgacatca tgctgtactg atcacaattc agattcattg aagagcaagtctaggagaat
56461 cagaggtaca gagcctgtag taagaattct ggaaattaca tccttcactacacatttctg
56521 catttttaat aaagggacaa agacaatatc cttttgagat attcccaggcacacaggagt
56581 gctaccagta ctaccacttc agacagctaa aactatgcag ggttggaagggagagatttc
56641 tcctttcaat tgcttcaagg tgtagtagag atagttggac aagtatagtttttgtttgtg
56701 tgtttgtttg agacagagtc tcactctgtc gcccaggctg gagtgcagtggtgcgatcgt
56761 ggctcactgc aacctccgcc tcctagttca agcgattctc ctgcctcagcctcccgagta
56821 actgggatta caggcatgtg ccaccacacc cagctaattt tagtagagacggggtttcac
56881 catgttgacc aggctggtct tgaactcctg acctcaagtg atccacctgcctcggcctcc
56941 caaagtgctg ggattacagg tgtgagtcac cgcaccggac caggacaagtatagtttttt
57001 aaagcctcaa tcatttcttt caaatctgtt tgtgttaaga aataaagtgactttcaaatt
57061 caagggccat aagtgcccca gggatgcctc aggtcctttt ccacctgggtgagtccatgg
57121 gaccagcctc tgaaagccac tatttcttgc taccttgcac tccccccgggactcaggcag
57181 cagggccaga tcccatccca gcaggccggg cagccggctt ctccaggcagggcctgcttc
57241 taacctacca tctcagagca cttcccctct ggggaagtggggaaggggcaggggagaggg
57301 aagtctgtgg ctggagcagg ctgcaatggc aaaggctaac tatgtaggtcacacatgcgg
57361 aagggccaag gactccaaga ataacacagc ctaggaatgg ccaagaagtaatggtgcaaa
57421 gtcaaacgct gagccctgca ggagactcct gggtaattca ggagagacatagttgagcag
57481 cacggctggg caaaaaggaa tcccaagcac tgagacagga agtgacccacgaggaggccc
57541 acaaaaacta cacttctgaa gctgggccta tggcaggggt caggacagccagcacccctg
57601 tccttggggc cagcaggtgg ggcaaaatcc cacaggatgc ttcagggcaagccagccagg
57661 gtggtccttt ccccaccatc acacgattat ttctggtggg ttcattgatctgttcaatgt
57721 tatgtcacca gcaatttaac atgcacagca gtcccttccc aaatgtttgggtgctcaggt
57781 tctttttgaa tgagcccctt ctttgtaaac atgggtatga tctgtgagattccacagatg
57841 acagcatcct gatctgtaaa ctatgctggc acacagacca tacctgtacctatgggtgcc
57901 agccctgggg ccttttagct aaaatcccaa atggtcagga atggatgggattcttgccca
57961 cagaaaagtg cagtcctacg gcatcgaggc aaaggacctg agatgcagtaaaaatattgc
58021 tggcctagaa cacaggagct ttctgcttca atcccagttc tgccactcaccgtgtgacct
58081 cgcgattatt gtcccctctc tgagcctcag tctttttatt ggttgaatgaggagaagtat
58141 gtggccctca gaggattgcc aggaagatga aatgagcaga catctgcagacattgcagac
58201 atctagaaag gcctttggcc ctatgtagtc tctttttggc ctgtatgtgtgtgtgtgtgt
58261 gtctgtgtgt gtgtgtgtgt gtgtgtaact cacctccccc atcagaagggaggaagcttt
58321 tgaaaataat tccaaaggca tcagctttga ttttagagcc tctttctttccctttcttct
58381 cattgtcgta tttcagatgg tatgctactg aagagtgcag acacatcagccttcttccat
58441 tcctttttag gaattcaaag aacatgctaa tgttccctaa attgtgagctgctgccacgt
58501 gaaaagggtg attctcaatt gctccctcac tgggatatga acgtgctttgtcctgcatat
58561 gaacagtaaa gaaaggtcct ggggttggga tagggccagg tttggggaataagattggcc
58621 ccacaatcct gaggagaggg gcttgaggtt tctaggtcat ctgcctgaggacagaaaggt
58681 tttccccaac ctcctattgc ccagcataaa gaacaaggat ctggggtcttagaaaccata
58741 gtcaagcctc cacagggaga tgtgtgaccc aaaaagggtg gactctgctgtaagcgagct
58801 ccaggttgga gcctacacct ggctccacct ggacctacag gatgatggggccatacccag
58861 gaggagggag aacgggaagt ggagagagtc aggtatccac tcatgcaatatggatggggt
58921 aatggaacac tgcactttac cctctgctga tcctgctcct ggggcttcctggtgccagga
58981 accacaggct cggctgcagg gacatcactg aaggacagtg aggacccctgccccttttcc
59041 tcagccccgc tgactgcaag gcccttcacc tgggggcaca aggtcgcagcaagccagagg
59101 aagaggtagg aactatggag cctgccataa gttcctgggg ttgggggaaaggggaatttg
59161 gcagtgagag gggacaggta gaaggggcaa aatccaggac cgaagatagatgggaaaggg
59221 cctatctccc cctttttcat ggggaccaag gagcatccca gaacacggagaggttggaga
59281 aagacaagtc aggctttgag caccagggcc atctgagaac tgaacagctcgtttcaacca
59341 catctcccat ctcctcatcg gcctctgccc ctgagtcctc tctggtccctgccccgccgt
59401 tctgatgctc tgtctccagt cctcgggctt tctctccaac cagctgagccggggaggatg
59461 agcgtgggga cactggcagg gctcggagct ctgaggagac tagactgaggggctgggatc
59521 agactgaaaa gtccaagacc cagaggagct ccagttaaaa cggctctttccggctcaaga
59581 ccacgttccc tgcttgctgg ggaccccatc cctctcctcc gtgtgtgaaaggatggcaaa
59641 ggcggaagtg gaggggtctc tcactgccct gattccccct cctggctcccaatttgggaa
59701 gacagatccc gatctgtctc gggaccagta ggtgaggggc cgggtccatctcccttctct
59761 gatgtgttct ctcatgtttg gctcttctgt gtttgtgtgt tttcctccatgcgtccctct
59821 ccctgcacct cattctggtg gcccccctca cagagccggg aggagcgtgttctccgccat
59881 gaagctcggc aaaaaccggt ctcacaagga ggagccccaa agaccaggtaggacaggtgc
59941 cgcgtgagcc ccgcagcccc gcgcctcgcg gcgccctccc gccgctttccagcccctgcc
60001 cggctgccaa aaggccctcc tgggataggt cgtcccaggg ccaggccccacccagtgatg
60061 cgtggccctc taggaaggag acgccctagg gccgagggag ggaaacgggcagcgccctct
60121 gtcgggggtg cctggttaca aggctcctcc cgccctcgtt gctcccggttcttccttctt
60181 cacgcagaag cccagtgttt taattagagc agagaatatc catcaagaaacgctgtttgg
60241 ccaactccct atttctgggg ggaaaccgtt gtcccactag tacggggtcggcggcaggcc
60301 tcgcccaagc gctctcacca ggctgcagcc tggcctttgg ggaggtcctggggccgctgg
60361 agggcgcggc agggccgggc ctgggaggct ggagcagcag gtggcactgggccctcccgg
60421 aggagcgact ggagagggga agacagctgc tgcagaggag gcgggaggcctggaggaaga
60481 caaggggaga aatggagagg acaggggagc tgggaggggg ccatcttctccatcacgggc
60541 ccaccatcgg ggctcccggc tgccctcccc cagcatcccc tctgtggcctactggccctc
60601 aggctctctc ccccaccctc ttgcccccat gccaattcca gccgtgcccttcaccttctt
60661 aaatggagag agtacagctg ctggctgagg accaaaccca gcatccttgggtggctgttc
60721 ggaatccaca tgtctgcatc tcattagatg aatacacacc aatgcattaggttctgaatt
60781 ccatcagctg tttgatatgg ataagttact tcctaagcct tcgtttctgtacctgtgaca
60841 tgagaataac gcccatcttg gcagggcaca gctctaagga ctagagatagtcatgtaaag
60901 tcctggtgtt gtgcctggaa cagagagtat ccacccaaca aatggtagctatttattgag
60961 aggtgcaaaa gtatggattc tttattccct accttcttcc ataagagatattcagtgcct
61021 aagtaagtgg tatacaataa aagagcattc aattaaaata aaaaggcaagaccagacata
61081 atggccattc aaatccaaga tcgggattag gtagaaaaac actgcagttattcaggccat
61141 aatattctaa gcggtagcaa ctaagtaaac ctcgaattta actctcagctttctggatgc
61201 cagagtaaaa ggagaaatgg tcactatctc accatcagtc agcccacctaaccagtcttt
61261 catcttcccc agatgaaccg gcggtgctgg agatggaaga ccttgaccatctggccattc
61321 ggctaggaga tggactggat cccgactcgg tgtctctagc ctcagtcacagctctcacca
61381 ctaatgtctc caacaagcgg tgagtggacg ggagccctgc aaccccagctgcccccaccc
61441 tgtcaggcag gacctggctt gccatgattg gaatttgggt agggaagaatcagggctcat
61501 ggacggcttc ttcctaacct aaccttaccc ttttctgctt ttccttgggtgtttttctca
61561 cctctctccc tgcaaaagca gagcacagca gctgcaggcc tgttctcaggtccttgaata
61621 cctcccagcc caaggaagcc acagacctgc ccaccccata tttgaacctattgaccccat
61681 gtctgtctct ctgttacttc tgcctttgat tagttctctg tgttgaggcctctgaagaca
61741 actaatcctc actattcttg gcagtgcttg agtgtttaaa gaccatgattctgtccctct
61801 gcccactccc aggtctaacc actgccagtg tcctcctccc caacaagcagtccccatacc
61861 ccaggcctga tggtacattc tcttcctcag atctaagcca gacattaagatggagccaag
61921 tgctgggcgg cccatggatt accaggtagg tgggcacctg gaggcctcatgtctttcaga
61981 ctctgctcta gtgggggatt ctagccggat gtgcattatc cactatactgaggcatggat
62041 ccaggggtca tagagaacaa caagctgaat ataagttccc aaagtaagcttgttcctggg
62101 aggcattcct agaagtatca tcagtagaga gatacaaacc caaagaaaagcttgagaact
62161 ctgcctatgc taatcaaagc ccttccagta tttcatgttc agtattggacttcataaagt
62221 gagaagcacc tagaaaaacc ataaagagac caagaactac aaaaaagtattcaaacagtt
62281 aaaataaggg cctttgaaga aagttttcct ggcatgattt ttaaattgttgttttgtatt
62341 atttgattgc tggaagtaat gacgattctg tttatctctg gatggtgagactgtgagtga
62401 tttttttctt ctttttgctt ctctgtattt tctgagatta acacaacttttttatttgtg
62461 tgcttctaag accagagaca aaagactgag acaaagagag gttgacagctgtaagaatgt
62521 gaatgtggcc aacagtgcag gcaggacagg tgatgagcat gtctggtggctgctgggaca
62581 ccatctctca ggaagggccc agggaccctc cattgctcca gaccctcccttggaggctaa
62641 caggactcag ctataaatca gaagactgct gggctttcct aggattgagttagaatgctg
62701 gctgctcaga ggggacaggg cttgcaagag atctcacctg gctgccactgcacttctgtc
62761 ctggggatgt tcggtctggg tatcagcacc aggccccaga atcagagtgagccccatcta
62821 ccagggtaga gctttatctc tgatgcctag ttccagaccc caagcacactaacccttctt
62881 tacggacaac cccacctccc ctcactcagg tgatgatgga aaggataagatggcactttt
62941 ctatgtaaaa ggtacatctg gccatgtttt ctccagaata tacttcatctcccttcatct
63001 ttgttttagt tagtttccat ctactcaggc aactgtcttc ccaggtgcctgaaaaacagc
63061 cccaggcaat gtcaaacgga cctgcccctg tggttttaaa taacttcaagccattggatt
63121 ccttaggggt ttgagaatgc cggcccctca cctctgccaa aacccaaacacaaagtgtcc
63181 tgagacttcc gagggctttt ccaagggatt gggctcaggg ctttgtttctctgtgtgctg
63241 agaactggag aattccaaag aacaacgacc ccaactcagg tatcatgtcactggcctaag
63301 aggtaaggac acatcaaaaa tagagtcatt attgttcatg aaacttatttttgaaggttt
63361 attctatgcc aggcactgtg ctaggagcta tatatgtatt tccattgaagttaatgtaat
63421 tcttcaacca cccaaatata ggtgttactg catttatagg taagaaagtgaggccccagg
63481 aaggtcagga acttgtccca ggtcgttgcc actaagttag ccaaggttagagccagggtt
63541 caaggccagg ggtgtctggc catagccata agagcaattg acttctctatatcaagcctt
63601 ctagacagct gctcccttcg ggtccctggt tcatcttcat cttgctacttagtgcttgtt
63661 ttccaaacct tttcaaactg cctcctacca gagactttta ttaactggaccagacattgt
63721 cccctccaaa gactttttaa accgaactga acaaaacggt tgttgtatttaacctggtag
63781 catagtgttt cccgacaagt tcattcacaa ttaaccttgc aaacatttgagtgagagcta
63841 tgaggatgca aatgtgaaat tattttcact tccaatacat acagtgtataatgcaataaa
63901 agcaggccgg gtgcagtgac tcatgcctgt aatcccagca ctttcagaggccgagatgag
63961 tggattgcaa gaccagcctg gccaacatgg tgaaaccccg tctctactaaaaatacaaaa
64021 attagccagg catggtggtg gcgcatacct gtaatcccag ctacttgggaggctgaggca
64081 ggagaatcac ttgaacccag aaagtggagg ttgtagtgag tcgagaccgcaccactgcac
64141 tccaacctgg gcaacagagg gagaccttgt ctcaaaagaa aattaaaaataaataaataa
64201 ataataaaaa gcaataaaac cagatacgac ttcactctct tggagactttgggtttgatg
64261 agatataaag accgcaggaa ggacacctcg ttggtgagat gtggggagacttagctgaac
64321 tcagatccag gaagggttgt gagggctcag gaccattcta aaggttatggcactgaaaga
64381 agcctggagg taaaaggacc gcggcgtacc catgctcttt gtttcttccatttagaatgc
64441 acgtcacgtg taaactcttt cctgattatt gccatctcca aggcaagaaaccacagtcac
64501 ccccctgtga atgtgcagtt tccccaccag agtgagcaac gcttggcacttggcagagat
64561 gttcttggtg gatcaagggg tcttgagtct ctttattacc atctcttcctggcaccaaga
64621 cttaatacat tgtcacccaa catctctcca gttttcacct ccatttcatgcccctgccac
64681 tgacctgagg tccccagcct caactgcatg gttgtaccta ctttctacctggtctccctg
64741 ccctcatatt gcctcctcca ctccaaactc catgccacca ctggagcaaacttctgaaaa
64801 tgcaaatctg gtcatgtcac atctctgcca cctggaaaag tggggagtgggtaatggatg
64861 ttgcagaagg acagtactaa agggcgcacc aactctcatc tctggctcccagcagatgtt
64921 cctgaagctg gatcaggtcc ctgggaagca ggtcacaaag cattattactctcgggtttt
64981 cccaggacag gggtatagat ttaccactca gcattattcc ttgtgatcgctttcatgaag
65041 ccactgggga gtatgtccct tatcttgaaa ggagatggtg gaatagtcagctggtcagtt
65101 ggtcccagct gtggctccgt ttgcctcttc atcttccacc ctggaaaaattgagtcctct
65161 gctgatgatt ggagagaagg atggccaagc ccctccccca gaaccctggagaatgaccag
65221 ccatttttta ttttttattt caagtgcatc atttcccctt cctagagccccaggaggggt
65281 gggaggcagc aggaatggca ttccccttcc cccaacacca tgcgcctggtggtctttctc
65341 cagcgccctc agcttcctct cggggctgcc cttcaaccag caatgagcaccctctggagc
65401 ttctcttccc tccgttgctc cttcaagcct ctgcccacct tcccctccaccctccgcctc
65461 tactgccaga gcttctgccc aggttgtcac cttcactggc tctgctacatggaggaaggg
65521 agaaacgtat gaggcctgaa aagggggaca gggagaagta gcctgtcttatggccatgcc
65581 tcgagatgga aaacataaaa accaaccact ctcttggcag tgggaagaggacttgctgct
65641 ggcttatctt cggtagatgc caaaactatg tctgtccgct tcccagtcctgagttataga
65701 aagccttttt tattgttggt gggggcatta gttgtggaaa aattcatggggtttttaaaa
65761 atctttggca aaaaagggtt cgtggaagtt aaaactctac aaactattgtgcaaagaagg
65821 acttctagtg tccgtttgct ctcttcatag taaacttctc agagctaagttagttagtcc
65881 tatttccttt ttagctccct gaaggagcag tgaatattga acttctgtgaagctccagat
65941 tctaagcttt tacttccgtc cctttgtcac ttcacgttcc aaacggaaatgtttgcttcc
66001 tagttcaagt gtcacttcat ttgtaaatat cccctttcct ggcaatgttctcattaacat
66061 tggaatttct atttccttaa catgattact tctgatgtgt agatttttaatcaccctcag
66121 gttatttttc agactttgat ggacactgga tgatcatttt agtggttattctttttcatg
66181 gaaagggaag ataattctct caagtaaagt cgtatttaga agttgcatcaaagcacaact
66241 aaaatatgaa atctccaaga tgacaggcat gaaaagcaac cttcggagtcgcattagaag
66301 aatgtgccgg gctcagtggc tcacgcctgt aattccagca ctttgggaagccaaggcagg
66361 tggatcacga gggagactga gaccatcccg gccaacatgg tgaaacctcgtctctactaa
66421 aaatacaaaa attagccgtg cggtggcagg cgcctataat cccagctactcgggaggctg
66481 agtctggaga atagcttgaa cccgggaggt ggaggttgca gtgagcctagatcgtgccac
66541 tgcactccag ccggggcaac agagtgagac tctgtctcaa aaaaaaaaaaaaaaaaaaaa
66601 aaaaaaaaag aagaatgtac agaggtccat gcttattcta gctggggaaaggcttttctt
66661 gttaaaacac acgtttgaga gaggcaagtg aatcaatcat tctaagtatcatgcacaagc
66721 tccctacttg agagatcaac cgcttagctg aagggagatt ctgttggggtcactcacatt
66781 ttgtagagct ttctgctgtt taggatgcat tttgacacac atgatctcatttaacctgca
66841 tacaacctta caggtagctg gtgtctctgc ttgtaactga aaaacacaaggctatgtggt
66901 catttgccct cacacctggc aacatgtcag gtctggggtt caatcccaagttcagcaacc
66961 cccagtacat gcctctgtct atcttaacat ggccaccctg acaggaactgacacctccaa
67021 atccaaatga gacctgatgg cttaaaatga gggttcggga aaagtagtagtgatgtcaaa
67081 aattactggt gctctggctc tctctctctc tgtctctctc tctgtccttatatcttttta
67141 gcttaaaaag ccaataattg gctggtcaca gtggctcgtg cctgcattcccagcactttg
67201 ggaggccaag gcaggcagat cacctgaggt caggagttca agaccagcctggccaacatg
67261 gtaaaaccca atctctacta aaaaaaaaat acaaaaatta gccgggcggggtggcatatg
67321 cttgtaatcc cagctacttg ggaggctggg gcagaagaat cgcttgaacccaggaggtgg
67381 aggctgcagt gagctgagat catgccactg cactccaggc ctgagtgacagagagagact
67441 cagtgtgaaa aaaaaaaaaa agccattaat catttgtggt aagctccacaaggaagaatt
67501 tgttgcaatc ccacctgtgc ctggctccag caggtttcca ggaaacatttgttgcatgaa
67561 tgaacaactg aaatagggct tcccaggata taagtaagat tgcagagctggacgccacat
67621 aaaggacaca gcagagtgca cacaacatac aatcagtagg ctgaaaaaggcggctcaggc
67681 aggcaccaaa gccgcactgg ccatacaaac aaagaaattc agcaaacaatgtggaaaggg
67741 gggggagcca aattccagaa atgcaaagac gtatcagagg cctgcaggcttacatgagaa
67801 ttcctggagc aggaaattaa atgcaagtta atgaagactt tgaaagctttattcctgagt
67861 gcatgaaacc tgtgacatgg gtttggcagc tctttctgaa gcagagccatcgacgctggg
67921 gaagaacgca gggcacttgg catcacctag gagctttaaa aatacagattccagcctggg
67981 cacggtggct catgcctgta attccagcac tttgggaggc cgaggcagacagatcacttg
68041 aggccgggag tttgagaaca gcctggccaa catggcaaaa ccccatctgtataaaaaaga
68101 caaaaattag cccggtgtgg tagtgcatgc ctgtaatccc agctactcaggaggctgagg
68161 cagaagaatc acttgaaccc aggaggcaga gggttgcagt gagccgagatcatgccactg
68221 cactccagcc tgggcaacag agtaagactc catcaaaaaa ataaaaatacagatgcctga
68281 gctgcatgtc caggattgga ttggattggt ctggaggtgg cctgggcatcagtgttttta
68341 atgcctctcc ctcccttcgg cccagcaagt taagtctagt gaacactgacttagaggtta
68401 gccaactcat actcctctat aaatgaagac acttgaggca tagaaggagaaagagccagg
68461 atcacccagc agatgagagg cagtggtcag aatggagccc aggaggccagtgctggctcc
68521 cgggccctcc ctctgaccct gctgccccag cccctggacc cctgcgggaccaggctccta
68581 ggctcaggca gctttccttc tggctccccc ttctcctgcc tgcaggtcagcatcacggtg
68641 atcgaggccc ggcagctggt gggcttgaac atggaccctg tggtgtgcgtggaggtgggt
68701 gacgacaaga agtacacatc catgaaggag tccactaact gcccctattacaacgaggtc
68761 agtggccctg tggggaaagg agcctctgta aatatggcag gagggtggccccagccctcc
68821 ccaggagaaa taggagtggc tggaagtcaa ggagcacaca gggctaccagcaggggtgat
68881 ccaccctgtt acaaccccca ggacactgac aaacagagcc acatcttctgaatcctctga
68941 accccccagt ctagagcaca ggccgacact ggtctttgaa gcgtacaccacccgggtgct
69001 cctgggcaga ccccagcagt gcctgtgaaa gaaccccccc ccaccccactccccaagagg
69061 cctggttccc actgtttccc aggccagagc ccaaggacag ggctgcctcattccaaccca
69121 tggtggcact ggcaccatta gtaagcactt tctaccagcc aggcatgctcctaaatgctt
69181 ctgaactgga ccatccaaag ttgtcactat caattccctt ttacacaaggggacagtgag
69241 acttctgaag gcagaccttg tccaacctca cagtgccagc atcgcccttggcgtgctagt
69301 ggggttctgc cctcttggct cggctccttc atggttgcct aaacttctgcgggcttctct
69361 ccagagcact ggccttgatt ttagggtgtg aaagagaaaa catttggtacccactcctat
69421 tctttccagc catttgaggc cacatcaagg gtgagggacc tcagagaccttctactttaa
69481 tctccccatc ttacagagga ggatactgag gcctccatat ggaagggccttgcccacaat
69541 ctcagagagt gttgctgata gagcaggggc caggctgccc acccagcttccagcccaggg
69601 ctctggccac catcacaaat atggcacctt ggttcccagg ctccagatgggaccccatca
69661 taatcagctc tggggaggga tgtgagaaat agagaaatac actcactcatcaaaacccaa
69721 agaatgactt agaggcatga agaacagcga aagtgagact tttaataacggtcttgcaag
69781 atggagtgtc tggtaggcag gcacccctgg ggcagtcaca acaggaatttatctcctagt
69841 gtgcaagtcc ctcccccact tccccattgg ttgagcacta tggggttacaatcttccctg
69901 acgtcgccta agtttcattt tcccccttac aaggttatac cccgctccccttcgatttcc
69961 ccacttaagt ttcgatttcc caataacaaa actttcttcc ctttcatgggctgacccctc
70021 ctctacattc tgttcgctta ttgtgtcctt ctaggtgcat gagccgtgtggtttgttgca
70081 ttcgcaggtt ggatgccagt acttagactt atcctgcctt gaaaatggaccattgaaaat
70141 gttttctcac caggatgccc aggcctttcc cagatgcctg atcacacatcagactaaccc
70201 agaagccaca ggcctgggcc ctgccatccc tttcctggag ggttccccagtctgtttctc
70261 ctggtggctc caggcagtga ggggtgccag gctgtcccaa gtaaggcagctgagtcccgt
70321 accctgaggt gggtgagggc tgaggtgccc cctgtagctt gggggagggcatttctcagg
70381 cagctctgag agtcctcaga ctgtgcacct gcaggaagaa aacccaggcccacctctgcc
70441 cttcagccca ggcctggccg aactctcctt tgtgaccaca aattgactctgctctcccag
70501 ctgctttccc acaggccccc cgagctggac aacctgctca ggacccctccagccccaagg
70561 acattcagga ttgacatctc tggccttacg ttaggacaca tcctgactggacaagtctcc
70621 gcctagataa gcatctatgt ccccaagaca ggcatggaga caggtccctgtggccccggt
70681 ggttacttga tagcagtgaa gccacttctg ctaacttaag ggatctccctccaccaggcc
70741 cacacacctt ggctttcatt caaattactt cctctttccc aagggcacagagctgctctc
70801 cctactctgt ggctccccca gaaaactcct actcacccgg cagggcccagctcaaatgtt
70861 cttgctactg agcagccttg cctgctctgt ctgggtcaga ggtcagcactcccctttctc
70921 tgcagtgtta atgtcctgga gttgaggttg gtcctccgtg tctctgtcctgctggtggac
70981 tggaggctcc cagtctcctg cctcgctatt tgttcagagc caggcatgtactcggagggg
71041 ttcagtaaca ctcacccaaa ggaagacaca aacatccact gagcatctgccgcacaccag
71101 acagtggcac gtggggcaac atggaggctg ccgagatgaa ggaggcacagtttccgccct
71161 gcgcaggtcc cctccttgtt tcagcctaga atctttctaa attccctatttacttcctct
71221 aagactgact attcattctg ctcatctttg gacaatctta aatgtgtttctgatcacatt
71281 tttgttcttt ttcacaaacc caaatagctc tgattttgtt tctgtttcctctaaactagg
71341 gtttctcaaa ctcagcacta tggtatcttg gactggataa ttgtggtgggatcgtcctgt
71401 gctgtgtagg atgtgagcag catccctggc ctctacccag tagatgccaatagcaactcc
71461 ccttagttac agctaccaag tttccagaca tgccaaatgt cccctgaaatcgccctcagt
71521 tgagaccacc attctaaact atcttactat gattccttcc agccccaaatcagcctttcc
71581 agccccaaag ctttgtttcc cttttcttct ctttctatgc cacattccttttcaatgaag
71641 gacatcctcc tcgtcgtggg aatgtattat ttctgactaa ttatctgagctggtaggaac
71701 cttcctttgg ctccattaaa acaacagagg gaggtgggaa caatcaacatgacttaggta
71761 tctaagctat tacaaaagga aaatatgctc aggaaataac aggaatttgattgcagacag
71821 ctcagagagt tcgggattct ggctctagct cagctagctc gctcccctggggctggcaca
71881 tctgcgggca cctggcctga tcaccctgcc tggccctgag cctgcctgtgtgcagggaag
71941 ctcaaaacct ttgcccttcc ggaacaagct ggccattcac aaaccagactaaggctcctt
72001 tcctgtgtgt cctgtgtgtg catctggccc cgccctgggc atcttgggagcgccaccatc
72061 cttcctcctg ctgaaaatcc acctctcccc tttgccttgg atccttctctttctacagct
72121 caaagaacct ggcattgcac agcccaactc tgtctttgtt tttcttccagccccttcttc
72181 cttgcctata aggtgttcta ctccagcata tgctaagtac aaccatgaagacccatgtgt
72241 gctcaaggac aggaactagg agtctgtcac ctctctctgg gcctttcctcattcccacac
72301 acttctccag tgacctcctt tttccctcca cccctccaca gtcagaccacttgggttgtc
72361 ctcacttcct ccccccagtc acccctcaat ctctgcaggg tttctgcctccagatgtcat
72421 tgacactgct ctcctcaagg tcaccaagga cattgctgtt cctgagtataatgtccatgt
72481 catcctcctc tcccttgatc acccagtttc tttcatcccg ctgcctgctgctcctcttgg
72541 gggcccctca cgccactctc ctgcttcccc tgtctctcca gctccatctccccggcctaa
72601 cttcttggct gaaaggctgt gtcttcttgg agccctgacc tgggcctgcttcccctccca
72661 tgctctcccc aggtatctcc tccatctcca aggtgtcagt taccatcttgtgctgacgat
72721 tcccaaatcc atatccccac ccgcctcccc agagcttcag aactctggccagcacaccct
72781 gggcctgtta gtgtcatgca cagctgtcgc tgcttgctat gtgcttaccgtggtgcacac
72841 ctgtgttaaa gacttgacca gggtgtctca ttgcaacttc acaaccacaccttgaagccc
72901 cccaagtgaa tggcacccct ggagcagttc agcacgacag ccctggatcatatctccaca
72961 ttcataggat aataggtaaa ctgaggctca ggcaagaaag tgagtgatctagcagtaaca
73021 gccaggtggg gctggctctg aagctggctt taccctcagt gctcaagggccagcccccag
73081 cagccaggag cacgttctct tcggacattt accccaagca cattggaaatatttctccct
73141 tctcccccac cacagttcac caaagcagca gcccctctac tcactgccccacaccctcat
73201 cctcagcacc tgcacaccca ggccagggga agagatgggg actgcaaatgtgcatggcag
73261 cccacagcac caaaggacag tgcacaccca tggcatttca catcgactgccaactaagtg
73321 cttggcacac catggttcat ctgctctgag gcttgcgtta ttttacagtttcacctctct
73381 gaatttggga tgtgtctcct aggcagcctt gtggcttcat ggcaatgtccatgtggctta
73441 ttaaaccgta gtatatctta cagccagtag ccactttaga tttggtaaaatatgttacac
73501 tgtctcatca gagcctcata acaagactct gaggtgggtg tcattatccccatttcacag
73561 ctcaaaaaac tgaggttcag agaatgtgtt gctcaaggcc acacagttaagaaggtgcag
73621 agcggggact agaacccagg tctgcttgct ccctggccct gtgcctcttctgagcacagt
73681 acaagggcat gggctgtccc acctactgtt ccaagttcct ttcccaccccacactagcca
73741 gcaccagccc cacctagggg atggggctct gcttcctacc acccaccaccagggtcaatc
73801 aggatcagat gagttgcctc tgctgctcct ctgaactttg gggctcagggcaaatgtctg
73861 gggtgcagac aggccctgcg aggagggagg ggcccaacac tgcctgggctgttgctgctg
73921 ccctcagtga cagcaggcct ggatccttcc ccctccagta cttcgtcttcgacttccatg
73981 tctctccgga tgtcatgttt gacaagatca tcaagatttc ggtgagtggggagcagcccc
74041 tggccggcag ggccactccc tcaaactgca cctttgtgca gacttgagaggggccccctc
74101 tgtctagacc catgataaag aggcagcgcc gtgcctggac acacggctgggcaagtaggg
74161 acaggctgga ttctggcccc cacccacccc tttcattgga tgcctctgaatagtgcattc
74221 gcccgtaaac agtggccagc aagaaactgg cgtgggcagg aggagctgatgctgagcctc
74281 agtgagccac cccactctgc caacgccctc ccacttcacc acaaagctcgggtcccacca
74341 ctgccccatg gaaagcctca cccttgctgg gcctgacggg tgggctgtggttctgcctga
74401 aaggtgattc actccaagaa cctgctgcgc agtggcaccc tggtgggctccttcaaaatg
74461 gacgtgggaa ccgtgtactc gcagccaggt gagtacctgc gcatggccagtcagtcgagg
74521 tgtgcatggc tcagggagcg tggtgcacgg ggcccttccc actgtggcagttcctgggaa
74581 aaggctggca aggaccacag tctggcgact gttagtacac acagccatctggcctgcgga
74641 gaagtggcgc gcacagtctg tacacaaatg cagtgagcaa ctgcgcacccagtctggtgg
74701 gttctcactc ataattaggt gagtaactct gcacagagcc tggaaggagcttcatcacac
74761 gctctggagt gcatggcagg ctggtgcatc actggccata ggcaggctgaccagtagtgg
74821 tagaggatgc ggtgagggag acccgtcaca gcctgcagag aggctgcgcccagactcctg
74881 cctcctgggc tggcacctgc tgagcagaaa agaacccctt tccacccctcacaggaccct
74941 gccgtcccct tttacagttg aggctcagag ccagggcttg ccccagccacacagctggcc
75001 gggggtgaag tcaggctgtg tgtccccaga gcctcactga gccacactatccaatctgaa
75061 agcggtgatg ctggtcaatg ccagatgtag tgcggcggcc tctgagggactctggtctct
75121 gaaaacactt cttacaagag ccccaggctt ttgggcagcc atgtgtgctccgtggcgtcc
75181 tgtagggtaa cagcaatggt gttggcaagg gaaccccaag gggtggcccagagggcttgt
75241 gaggtgggcc aggcagagga agtgcctcag cctgccagat gacagctcaccacgtgggca
75301 ggttagggac caccctgtgt ccctgaagtg aatgcactgc tcagagtgctgtaatgaccc
75361 cattaggcgc tttgacagtg agaacataat ttcacccaat tgtcacattgggccctcaca
75421 aaacagtaat gtaggcagca gcatttcttc ccattttgca catgagataaatgaggctaa
75481 gagaaatgaa ggggcttaga gataccacta aactagtagg ttgaacaaattggcgatcgc
75541 ttgtggttca acctaagaga cgtccagctg gtgcacatta caactatgacttagaccagg
75601 gaatctgagt ccaaaaccaa gattatacac ataaaaatca caagatcatagaacactcaa
75661 gctgcccaag acctgaaaaa catctagtcc agcctctgtg aagataaactgaagcccaag
75721 gtgatgaagg ggtttgtcca ccatctagga gtagcacccc tgtctccagctcccaggcca
75781 gtgcctttgc caccacccca cacatgccat agccctcagc ggagggcagccctgctgacc
75841 atcagtgcca tggggagcag ggaagagtcg gcctcctgcc atgttgctttccaggaagca
75901 tgcatagccg tggactactt gcttggaatg actggcatcc ctgaggataagctcctccca
75961 gggctgagca gtggccctgg taccactggc aggcctgagg ccgagagccaagagaaagtc
76021 agggggtgga gaaaaaggca gatattagtc taatatggac ctctgggcttctgggtagta
76081 aagtcctggt gaggaaacca ccagggcatc agtaagtgcc agatgttgggctaagctcac
76141 tgtcccagca ggcctcaccc tcacgacccc atataggcat cattcccatttcaccataag
76201 gaaactgagg ctcagcaggc ttaaacagct ggtccagggc cacattgtgagtaagcggca
76261 gaaacaggat gtgggccgag gtctccactt gggtaaccta gctcgagatttgctgcttct
76321 gctgaatcca gccctgagcc tggtgccctc ccagggacag gagagcctgaagtcacatgg
76381 gtcctggagt tgagacccaa tgtctttact ctgatatctc cagtttggcctgaacttctt
76441 gatgagtcgt tggttccagc cagggcattg ttggacagca tgctcccagagacactcctg
76501 ggtgctgctg ggaagctttg ggtggtgtcg atatctcttg gaactggaaggggtttcccg
76561 agagaacctc ttctcaccct ggcaggacca cattttgtca tttgtaccaccagatgcaac
76621 atcaggaaac tgtttactgt ttgctactct ctgttggggg tgaggacgggccatacactc
76681 atcctcatag atcatagagg aagtcagggg catacactca tcctcatagatcataaagga
76741 ggtctgggat gcagcaactt ccccagctgg gctacccttg actggcaggtgtcagcccca
76801 ggctgaaggg aggtgaaatg atgtttcagg ctggtaagca tatagctcaggatctcatgt
76861 ggtccttgta tctctagcct gagatcacac agtattagga ctagaagggcctcagaagtc
76921 atgagtcaag tgttaacctg atgtagggac ccccacagca ccatctctgattggtcctct
76981 aaccttgctt agtcctccca gaaatggggc actcactact tcttattttagatatcttca
77041 ctttctttag gtcatctcaa aatctgtcac cctgtaacct tcacccactttcacacgtct
77101 ctctttcagg acaaaaagaa aaatagcctt taaatttgaa ggtaaattttacattcctcc
77161 tgaaccgtat tctctttctt tgctaaatgt ccccaattca tctaaccatgcacacctcta
77221 tacatctacc cctgtatcca tccatccact cacccaccca tctacaaatccatccaccca
77281 cctgtccaca gatccaccca cccatccatg tatccatcca ttcacgcaccaatccatata
77341 tccattggtc cacccaccca cccatccgtg aatccatcca cccacccacccgcctgtcta
77401 cagatccacc cactcaccca tatatccatc catccaccca cccacccatccatatatcta
77461 cccacccatc tatccacaga tccatccacc tacccaccca tccacagatccacccaccca
77521 tatatccacc catccaccca cccatccata tatctaccca cccacctgtccacagattaa
77581 tggctccttc tatccagtaa tccattcacc atctgtccgt ctatctctcagccggccagg
77641 cagctcacca cccatccctc tgcccattta tgcacccatt cattgagctttctgtccatc
77701 tcctcatccg acacacatct gctctggcaa gacctgaagc tcctgggattcctgggacat
77761 ggcccctccc tggaggcctg ccagcctggc tgaggttctc cagtgactcctcatccacgt
77821 gccttcctgc cctctcacct tgcttgtccc tctcttcaga ctctactgtggcattatctt
77881 ttctgagaca caggtggcct ggctattccc agaaaggcca acctctgtacacagccccta
77941 acatctccgg gagcccacca gggccacagg cttgcaggac acaggcctgggctacggtag
78001 aaggtggaag aggagggagt gaaggaggga ggtgctgagt ccctgagagttcagtgccca
78061 cctaacatcc cgggaagcag attcctaagg cacagtgatg cgcttccctttgcttgccca
78121 ctgggcttaa agtaaacctg aaggggcaaa tccttcctaa agcgcctccttccctgacat
78181 ccgtcctttc ctccacacag tcataggtca tgggacactg ggatgagactgacaatccct
78241 gtctttagga gactctcagt ctaaaatcag agccaaacaa tacccagatcagcacagtga
78301 gatgggaggt gtgcatggag agcacagaga acaaacacta aagagcccaggatcaactct
78361 tccgaggaag tcagggaggg ctgcatggag gaggagagac ttgagcaaaatgagtagaag
78421 tttacaaatt gaatagggag aaagacaggt ggaggtggag agaacaggaatgagggcatt
78481 ccaagctcaa agagcagcag atgcaaaggc atggaggtat aaaagggcatataaaaccgc
78541 aacacctgtt cagcaaggag gaacacaggg ctgggtgggc tcagcagagtgagtcaggga
78601 gcactaaatc aggagcctgc aggccatgcc ttttgtcttc accccaaggcactgggaagc
78661 cccagagggg ctgaagatgg ggagcaggag catgagcctc cacctgggaaggccctgtgt
78721 gcagctgtgt ccttcacagc tatgtgaagg ctggctgact ggggtggggccatagaagag
78781 gccacaggca gaaaaaccca attaggagga ggctgtcgtg cttccaagtcacaccactca
78841 tgggatatat gtccatgggc aggccatgca cccactgccc cagctccagaggacctcaga
78901 ctctatcaca ccctgggcta gggacaggca gagctgtggc cccaggtcccgggactctag
78961 ggaccaagac agcatttggt tctgccaccc cttggcctgc cctgagcactgggagacgct
79021 ctgggtgggg gtgtctggtg cagtgcccac ccctcatcat tgcagagcaccagttccatc
79081 acaagtgggc catcctgtct gaccccgatg acatctcctc ggggctgaagggctacgtga
79141 agtgtgacgt tgccgtggtg ggcaaagggg acaacatcaa gacgccccacaaggccaatg
79201 agaccgacga agatgacatt gaggggtgag gcccagctac cccagcccctggagtctgag
79261 ccagcccttc cttcccccag ggagcccccg gtgagggttt gctgagagcacctgccaccc
79321 gtctccctca ccctgctctc gctcactctc ccaagcagcc ccactcttccgaggcagggc
79381 aggggcaggg ggtgatggag gatggctgag aatatcagtc ctttgacatcctttctgcca
79441 gtgagaaatg ggttgagaag agtcgatgct ggcagaccag aaccagcagctgctgggtcc
79501 tgagtatagc agcaggaagt gctgggagag ccaaggtttc ttctggtgtgccaattccag
79561 gcagctgata gcagctgttg agaaatattc tgtgaccttg tctggagtcagtgggtaaaa
79621 gtgctgggaa tcaatgaatc ctgtcttttg tgagctgggg gagagagagtggctactgtg
79681 aagtttttgt ctacgaaaca aaagatacgg cacaaaacta taaaacactgacaataatac
79741 taagatcata tcccaatgta caatctacaa agcactcata tgttttagcgtgcttgagcc
79801 gatcatgttc ttgggaggtg ggtattatta cagccacctc aacagtgaggaaacggcagc
79861 tcagtgagat gggaagattt gcccagaatc ccacaagggg caagttccgtgaacacaagt
79921 gtctaatcct agccttgctc cctcagctgt cccttagaga ctgtgccaggacccaggagt
79981 gtgtagatgc caggatgggg gttggggacc tggacctggt gaccatggccctggctgtat
80041 gtgctggcag gaacttgctg ctccccgagg gggtgccccc cgaacgccagtgggcccggt
80101 tctatgtgaa aatttaccga gcagaggggc tgccccgtat gaacacaagcctcatggcca
80161 atgtaaagaa ggctttcatc ggtgaaaaca aggacctcgt ggacccctacgtgcaagtct
80221 tctttgctgg ccagaaggta ctggggtatg aggtacagga ggctggggctgggtgacagg
80281 tatcacaagg gcaggctgat gggtgtgggg cctggggcag ctgggcaggtaagacaaggc
80341 tggaaatcat gttggccagg gacggactta gaggatcctc actgcctcctggagtcctta
80401 gactgagagc tgcgcagggg gcatgagagg gaggagaggc tgggggtgtgggaagagtgg
80461 agacaagtcc acacacaggc acgcacacac acatgcaccc actcatacacgcacgcatac
80521 caactcacac acgcacgcat accaactcac acatgcagac acgcacccactcacccgtgc
80581 acacgtgcac ccacgaatac acacacacat gcacccattc acacacgcacacacacccac
80641 tcacacatgc acacatgcac ccactcacac acgcacacac acccattcacacatgcacac
80701 atgcacccac tcacacacgc acgcataccc actcacacgt gcacacatgcacccacgaat
80761 acatacatgc acccactcac acgcacacat gcacccatta acacacgcacacatgcaacc
80821 actcacacac gcacacatgc atccactcac gcacacatgc acccactcacgcacacatgc
80881 acccactcat acacacacat gcatccactc acacacgcac gcgcacccactcacacatgc
80941 acccactcac acacgcacac atgcatccac tcacacacgc atgcacacccactcacacat
81001 gcacacatgt gcccactcac gcacacatgc gcccactcac acacacacacatgcacccac
81061 tcacacacac atgccacgcc ctcacctgtg ctcccccttc caccagggcaagacttcagt
81121 gcagaagagc agctatgagc ccctgtggaa tgagcaggtc gtctttacagacctcttccc
81181 cccactctgc aaacgcatga aggtgcagat ccgagactcg gacaaggtcaacgacgtggc
81241 catcggcacc cacttcattg acctgcgcaa gatttctaat gacggagacaaaggtcagca
81301 gcgggagacc cggtgtgctg gggggcagag ggagtggcct gaagggaaggaatatgtgag
81361 atgccctctc ttcacaccac cgtcatcagc tctggtcctc agcctcacaggtgcttccag
81421 ggccttgcca gcagcccctg cctcaggggg agggtgagga tttgtggctcaggtcggctc
81481 agagctggcc tgagcccagc tgactggatt tgtcagctag tagttgtgtgacctgttttc
81541 ccatttgtaa agtgaaaata ataatgatta tatgatatga taattatagtatgatatgca
81601 cattatagca gtgtatatac tgcatttgta tataattaca gtgtgtgtgtatatatatat
81661 gatacctaat agtagtgcct atctgcagaa tcgcagggat tgactacctcctaggatccc
81721 tgccctgtgc tgggttccaa ggacatagag tgagataaga atctattcctggatcaaagt
81781 gctcactgtg tattgaggag atagatgtgc taccaaatgg tcaaaacataaggcagaaga
81841 cacaaaaggc cacatgttgt ctgatccatg tatgtgaaac atccggcaaatccacagaga
81901 cagaaagtag attgccggtt tccaggtgct aaagggaggg gattgggactaactgctaaa
81961 taggtgcaga gtttcttttg agggggtgga actgctctgg aagtagatgatggtttatag
82021 cacagtgaat atacgaaaaa ccactgaaat gtacacttta aaagggtgaattttatgtca
82081 tgtgaagtat atctaaattt ttaaaatgct ataagtgtgt tttttaaaaaaaggcagaat
82141 aaaaaggaaa tgaaccaaaa aaactggatc atgagacccc tgtcagaggcctgacaaatc
82201 ttagccataa gagaagggac ttgtgcctag gaattgggaa ggcttcgtgaggaagcagca
82261 tttcacaggc agagatggag agggatggcc ttcagcaagg aggggaggggtctgcactgg
82321 cagggtcacc gtggtgggac agagctgcaa aaatggcaca gggcccaaggtcatgctgcg
82381 gacttggaag gactggctct gtcctacaag tagactgttg acaattcctgctctaagttc
82441 caggaagcag ggagctagac tttgccttcc cactgcttcc agctcaggcccccgcaggga
82501 agaaatagac ccaagagagt gctccacccc agcgcagtgt aagaaggctgccccacacct
82561 gaatggcaca catgaagttc tcagctcagc acccaggagc tggaggccagggacccccaa
82621 aagaggcccc tcttccccag ggaaactgga tgtgacgctg ccccctcatttttgttccca
82681 ctgccacagg cttcctgccc acactgggcc cagcctgggt gaacatgtacggctccacac
82741 gtaactacac gctgctggat gagcatcagg acctgaacga gggcctgggggagggtgtgt
82801 ccttccgggc ccggctcctg ctgggcctgg ctgtggagat cgtagacacctccaaccctg
82861 agctcaccag ctccacagag gtgcaggtgg agcaggccac gcccatctcggaggtgagac
82921 cccaggcact gtgctgtccc ccagggcctc cagctcagcc cccttctccctgagtcacct
82981 gggtcccagg ctttgcctgt tgctgccctg tctacctgag gagtcatacctcaggataag
83041 gcttctcccc aggaagcaga ggcccccact cagccccgca acaggactctgccctcgtcc
83101 actgcctgcc tgtgctctgt ctcacaacgg ccgccaggtc tcacgatggtgcctcccctc
83161 tgcccctctt cccagccacg gctgtccctg tggtgtctgc agccagccctgcttccatgg
83221 atatccaggc tggggggccg ttggggtgtg ggctgcctgg ccccaaagccgggtgggatg
83281 cccccaccat ccacccccac ggcctgtctg tgagacggaa ggaggcctggcccccgacct
83341 gccaccctta ctcaagctca ggaacgcttt gaactgcctc cccacagagctgtgcaggta
83401 aaatggaaga attctttctc tttggagcct tcctggaggc ctcaatgatcgaccggagaa
83461 acggagacaa gcccatcacc tttgaggtca ccataggtga gtgctgggcccacgggggct
83521 tcgggcctag gtgagtgctg ggcccacggg ggcttcaggc ctaggctgcaggtggtaagt
83581 gtgaggctct gcacctcagc cctgtcctca ctcttgtagg gaacgttgacccctttcccc
83641 tgagaggcct caagcaccca caaaacacct ttgtgtgtgc atggggtggaccacgcccca
83701 taaaggggcc aaccctcagc tccacctaca gggtgaggct gtgtttgggacctggggcag
83761 agggcaggga gaagcccttc ccggggctgg agaggagaga gtgggaactcaggccacagc
83821 ctgggccagg gctgggcctc gcactcaggc gtcatgagga ctccctgactctcagcggag
83881 tggggacacg ggctaatgct ctctggctaa tgatgtgtca cgtctgagccccattccctg
83941 actctccctc tcccctttcc caaacccaag gcagcaccgg attggacggtgggaggggcc
84001 tggtggggaa tgcactctag gccttctggg cccattctgc tccaggcaactatgggaacg
84061 aagttgatgg cctgtcccgg ccccagcggc ctcggccccg gaaggagccgggggatgagg
84121 aagaagtaga cctgattcag aacgcaagtg atgacgaggc cggtgatgccggggacctgg
84181 cctcagtctc ctccactcca ccaatgcggc cccaggtcac cgacaggtgggcccagcctc
84241 ccatcctcct gtggcctggc cctcccacct ccctgggccc ccaagacctcacctcccgcc
84301 tctgcccacc ccaggaacta cttccatctg ccctacctgg agcgaaagccctgcatctac
84361 atcaagagct ggtggccgga ccagcgccgc cgcctctaca atgccaacatcatggaccac
84421 attgccgaca agctggtcag ggccaggcca ggggccagca ggggtggggtcctgggggag
84481 acggcgctgt cagagggcct tccctggaac acacaaagct ggtctgcccagggggctgca
84541 ggaacggccc cagcaggacc tctgttccca ttctcagccc caggtcccagggcacagaca
84601 aggacaggag ccacctctag tcactcagcc tccagtgaat cctggggcaggagtgttggg
84661 ttccctgatt tttccagaaa tcttaaaagc aaggctaggg agacaggtgtggtggctcac
84721 gcctgtaatc ccaacacttt gggaggccaa ggcaggtgga tcacctgaggtcaggagttc
84781 gagaccatcc tggccaacat agtgaaatgc cgtctctact aaaaatgcaaaaattagcgg
84841 ggcttggtgg cgggcacctg taatcccagc tattcgggag gctgaagcaggagaatcgct
84901 tgaacccgtg aggcggagtt tgcagtgagc caagatggcg ccactgcactccagcctggg
84961 caaccgagca aaacttcatc tcaaaaaata aaataaaata aaataaaacaaaataaaaaa
85021 gcaaggctag ggaagggaaa tggggaaaag ggagaagcga gcagtgtctgaagctcagga
85081 gctgccccct cctcctctgc ccacccctct ccccccatga gccatgggcactgactgggc
85141 gaggagtgca gctgttggca tgagacctcc ttctccccag cctggggaagcagggaccag
85201 cagataatcc cgcccttccc tgagctgttg ctgttccctg ttgaagttccctgaagctca
85261 gccagctcat attttataaa aatgaattaa aacctccaaa aaaatcaaggctaatatgag
85321 gtctgctccc agccccctgc caatgtcctc cttgtcatcc ctgtcttgtgactataacca
85381 caattaaagc ccatagcctt tgcagtgtga cctgggtctg cagttatctgcaaggcttcc
85441 ccctaaggag ctggggtaca agctgacctg tgtttcctgt gggacctgggtctcacagcc
85501 ctcccagtgc tctcagagcc agagccactc cctcttcccc caggcatctgttcccatccc
85561 ctgccacagg ctccagcatt ctggagtgac gtcaggatct tggcacatccagtcctaggg
85621 tttccctctg tctctggcca gccctgagcc ccgtagccgt gagttctgcccaggccctgt
85681 gagctcacca gagccacaga ctcacagccc agaggtggct tcttccttcaggaactgaag
85741 aacccccatg aacaccaaca tctccaggtt ctgagaacag aacctgggaaattgatgact
85801 tcctcatgat gaccgatact caggatggcc ctagcgagag ctcccagatcatgaggtccc
85861 tcactcccct gatcaacagg gaggaggcat ttggggaggc tggggaggcggggctgtggc
85921 ccagcatcac ccacactcct gattcacagg aagaaggcct gaacgacatacaggagatga
85981 tcaaaacgga gaagtcctac cctgagcgtc gcctgcgggg cgtcctggaggagctgagct
86041 gtggctgctg gtgagaaggg aggggcggca ggtgggggga ggatgaggcggaactggaca
86101 aaggggaccc tgccagggct gggcagatga ggaagaatct acagagcccctgctggtcag
86161 gctcgctaaa ccccggctcg ccctaccccc agccgcttcc tctccctcgctgacaaggac
86221 cagggccact catcccgcac caggcttgac cgggagcgcc tcaagtcctgcatgagggag
86281 ctggtgagga cgcaactgga cggcgggggc tggagggagg gcctggttgtgagaaggtgt
86341 cacaaccccc tttgtcatgg cccgagctgt cccccagttg ctgggttcactgacaccccc
86401 tccttcgcag gaaaacatgg ggcagcaggc caggatgctg cgggcccaggtgaagcggca
86461 cacggtgcgg gacaagctga ggctgtgcca gaacttcctg cagaagctgcgcttcctggc
86521 ggacgaggtg cggcccaagg ggtcggggct ttgcctcatc cagggctggctctctggggc
86581 ccctcaggat cagggggctc aatcaggagg ctagaccccc ttacccactgcccctggcca
86641 ccccccaacc cccagcccca gcacagcatt cccgacatct tcatctggatgatgagcaac
86701 aacaagcgtg tcgcctatgc ccgtgtgccc tccaaggacc tgctcttctccatcgtggag
86761 gaggagactg gcaaggactg cgccaaggtc aagacgctct tccttaaggtgctggagggg
86821 gcaggatgga tgggggcctg ggtcctttca ggggagcagc agcccccacctggggctgga
86881 agcctgagtg acagggtggg gccttcaagc agcaggtgct cagagaagagccaagaatgg
86941 gaaggacgtg ggggaagggg tggggaagga ggtgggggaa ggggtgggggaaggggtggg
87001 gaaggaggtg ggggaagggg tgggggaagg ggtgggggaa ggggtggggaaggaggtggg
87061 ggaaggggtg ggggaagggg tggggaagga ggtgggggaa ggggtgagggaaggggtggg
87121 ggaaggggtg gggaaggagg tgggggaagg ggtggggaag gaggtgggggaaggggtggg
87181 gaaggaggtg ggggaagggg tggggaaggg ggcatgacgg ccccctgcccatcctcctgc
87241 ctccaccgga ccccagccca gcgggatggc tgtgaagggg cagggcagctctgaccaggg
87301 cctctgccgg cccctgcccc ttccccacct cttgggccct ggcagccgtcaggctcctgg
87361 tgaccccatg cccaccccca gctgccaggg aagcggggct tcggctcggcaggctggaca
87421 gtgcaggcca aggtggagct gtacctgtgg ctgggcctca gcaaacagcgcaaggagttc
87481 ctgtgcggcc tgccctgtgg cttccaggag gtcaaggcag cccagggcctgggcctgcat
87541 gccttcccac ccgtcagcct ggtctacacc agtgagtgag gacccctcactcgaagcctc
87601 acctgggagg gggccggagg ggctgcccat cctggaacctcaggctgcccttccccacag
87661 agaagcaggc gttccagctc cgagcgcaca tgtaccaggc ccgcagcctctttgccgccg
87721 acagcagcgg actctcagac ccctttgccc gcgtcttctt catcaatcagagtcagtgca
87781 cagaggtgag ggcctgggag gagggagtgg ctctggcttt gagagcaccagaagcctgtg
87841 agcctgtggg gactggagcc tgtggggcct gtgagcctgt ggggcctggagccacaggtc
87901 agccagtgcc ccggtttctc aggggaagcc ctgcagataa ctgcagcagacgcgggtcac
87961 actggaaagg ctacgggctt tagctgtggt tatattcaca agacagggacgacaaggagg
88021 acattggcag ggggcttggg ccaaacctca tattagcctt gattttaagatttctggaag
88081 aatcaagaca cctgtcactc ctgcccccag gttccgtgga agctgagtgagtaggggtgg
88141 cttctgtttg tgcatctgcc cccccctctg tcacttgtcc cctgtctccccatcccatgc
88201 tgcaggtgct gaatgagacc ctgtgtccca cctgggacca gatgctggtgttcgacaacc
88261 tggagctcta tggtgaagct catgagctga gggacgatcc gcccatcattgtcattgaaa
88321 tctatgacca ggattccatg gtatgggtgg gctctggtgc cagggaccccagcagcacca
88381 cacctggccc ttgttccctg cactccacct gcgctgaggc tgtgccctcacctccgccac
88441 ccacctgcag agctccttgg ccaggtgctg gctgggaagc tgggagtgggggctgacatc
88501 tagctcctcc tgcctgcttg cggcagcctg accccttccc aggccagcacatcctcacct
88561 cctgtctcct acagactgag ccctggaggt gtgccagcaa gtcctgctgtcactagcctc
88621 cccaccccag ggctccccga cccctgccct cacctaccac aaccagtaacagccttgcca
88681 tcctccgtgg aggttctgga gcagggagta agggattggg gtgacccccgagagttagcg
88741 agccaccttc tcacatacca cctcagctgc tgaggtgccc agatagccctggactagagg
88801 taggaggacc tcatgtctag tcctgagccg ggcatctgcc atttactgactgcttggcct
88861 tgaacaagtc tttggtgggc cctgagactt ggtttcctca tctgtaaaatggggtgatca
88921 cacctgtccc ttacaacaac tcatggcgct gtggtaagga ccaaacgagatcacaggtgt
88981 ggacagcaag caccaagagg cttctgggtt gtctgttgcg tcagggcaaagctgacttca
89041 tgggccggac cttcgccaaa cccctggtga agatggcaga cgaggcgtactgcccacccc
89101 gcttcccacc tcagctcgag tactaccaga tctaccgtgg caacgccacagctggagacc
89161 tgctggcggc cttcgagctg ctgcaggtgg gactgcaggg aagaggggctgaggcctggg
89221 gactggaggc tgggagttgg ggcctagggc tgggggctgg accctgaaggctggggcctg
89281 gggtctgggg cctgggggtg gggcctgggg gctggaggct ggggcctggggctgggggct
89341 ggggctgagg gctggggcct ggggcctggg gggttagggc ctgggcgttaggtcctgggg
89401 gttggggcct ggagctgggg cctgggggct ggggcctagg ggcctctctcctacccatcc
89461 tgaccaaagc tgggggcgtg gtccttaggg ggtttccctg tctccccagatcatggcaaa
89521 caactcatgg ggaaagagac cctgtccctg ggctccccag tgtgtgacctgtgaccccca
89581 ttccccagat tggaccagca gggaaggctg acctgccccc catcaatggcccggtggacg
89641 tggaccgagg tcccatcatg cccgtgccca tgggcatccg gcccgtgctcagcaagtacc
89701 gagtggaggt gcgagggctc tgtgtggccc ttcccttttg gatgaggagtctgaggaccc
89761 aggaggggaa gtggcttgtc atccccctcc caccaccatc accaggagccagcagcagac
89821 ccaggctcct gccccagccc agggcctgcc cccatctgca ccaagtcgcactcccatgtc
89881 ccaggaccat gcccagccct cctgtctgca cccctgaccc tgcaccccttctccgggcag
89941 ccccaccctc atccctggag aacgcctgcc cctcctctgc tctcctggccctgctcccac
90001 cctttgaaat ctggggtgaa ctactgccca tcccactgcc cggttccctattggatggtc
90061 cagcaccccc atggctggct cccttgacta aggggctctc ttctctgcacccaccctcca
90121 acctctccca ggtgctgttc tggggcctac gggacctaaa gcgggtgaacctggcccagg
90181 tggaccggcc acgggtggac atcgagtgtg cagggaaggg ggtgcagtcgtccctgatcc
90241 acaattataa gaagaacccc aacttcaaca ccctcgtcaa gtggtttgaagtggtgagtg
90301 caggccctgg cggaggacat cctgtggcca gtgtggctcc actcagccagccggcttcct
90361 ctgccccttc ttggaggctc aggctcctgt cgccaacacc ccaggacctcccagagaacg
90421 agctgctgca cccgcccttg aacatccgtg tggtggactg ccgggccttcggtcgctaca
90481 cactggtggg ctcccatgcc gtcagctccc tgcgacgctt catctaccggcccccagacc
90541 gctcggcccc cagctggaac accacgggta tggccacatc caccctgccaccaagcctgg
90601 ctccacgccc cccagggaag ggctccaggt ctccgcccag tccaagccgcgaccagagtt
90661 tgctctttgg ggccgagggg gtgggcatag aagaaggtca ccctggtggccaaggaaggc
90721 tgcccaaggt gacgccagct ctacagccag agagggcaga actggagacagcctgggggg
90781 gcctgagggc agaaagcccc ttgcgctggt tgatggagaa gacccaggcctccccgccac
90841 ctccctccca ccggcctccg cagcttcccc ttatctcggg ctctcttcttccctccccat
90901 gcccatattt tctcccttga ctgcctgtcc ccctctccct cagaaagttccagaatcagc
90961 tttagttctc cgcaccttcc tgccccgcca atctcactgt tcctcttgctccttcctctg
91021 cctgtctgtc catctatcca tctgtccagt caggcttctc cggcgctgccgtgtgctgtg
91081 caatgggggc tcctcctctc actccacagg ggaggttgtg gtgactatggagccagaggt
91141 acccatcaag aaactggaga ccatggtgaa gctggacgcg gtaaggcgggtggggtcagc
91201 cccctgctgg ctgggaacat gcaacttcgt gtgacacatc ctgtgaaccagactatctgc
91261 cccgagagaa aaggacacta agagcctcct ttggcatgtg actgtcgggggctgagcttg
91321 attgtgtgtc caaacagctc cctcctaata ctatcctgga atgcacacgcgtgcgtgtgg
91381 tatgtaaatg tgcatgtgtg tgcgcatgtg tgtggtgtgc atatgtgcatgtgtgtgtgc
91441 atgcatgtga tgtatgtgca tttgtgcgtg catgcgtatg tgtggtgtgcatatgtgcat
91501 cgtgcatgta tgcatgtggt gtatgtgcat gtgtgtgtgc atgtatgtggggtatgtgca
91561 tatgcacgtg cgtgcgtgtg gtgtgcacat gtgcatgcat gtgtggtgtatgttcatatg
91621 cacgtgcatg catgcatgtg gtatgagcat gtgcatgtat gtgtgcatgcgtatggtgtg
91681 catatgtgca tgtggtgtgt gcatatgtgt gtgcatgtgg tgtgtaaatgcatatgtgca
91741 tgtgtgcagt gtgcatgcat gcgggtggta ggtaaatgtg catgagtgtggtatatatgc
91801 atatatgtgt gcatgtgcgc ttgtgtgcat atgtgcatgt gtgcatgtggtatgtaaatg
91861 tgcatgtgtg catgtgtgca tgtggtgtat gtgcatatat gtgtgcatgcatgcttgcgg
91921 tgtgcgtatg tgcacatgcg tgcatacatg tgggtgtgtg catgtgcactggcatgtggt
91981 atgtgtgtat gagagacaga gtgagccatc acagtttatt ataatcacctgctataattt
92041 ttactccaac aaatgacacc ataggtaatg attccttatg agatcatcagtgtcctttcc
92101 aaagagtccc tggttttcca tcccagccat tcacaaatga cacttccctggcctgggtca
92161 gaggaggatt tccaggtgga agctccttat tcctcctggc tttgggcctaggactgttca
92221 tctgccagag agagaactgc catctggggg ttgggtgtgg aagtggcgtacaagctgtag
92281 accctacagg gaagggcaga acgtgggcca gcctggaaca cagcccactgttcctttggc
92341 cacccaaaga aacatcctca ctcagaccct ttgcagactc accagtcagagtgctcttat
92401 taatgcaaag ttggccttgc gggcacaggg gctgccagca cacagtaatttccatctcgg
92461 ctcctccaca caccctgtgc taggccactg cctgccactc caggccccagtggctgattc
92521 tgcccctgtc tccttggttc ctctgcagac ttctgaagct gttgtcaaggtggatgtggt
92581 gagtgtgggg gccatgcagg ggctctgggg tgagagggtc ctttattggcaatgatgtca
92641 ggccaaaggg tccagcatca gggacagagc cagccccagc ccccgcatgcttgggccagc
92701 acacctcccc taagatgcag tggaaaagag ctgggtgagt gcaggactcggtgccagtcc
92761 tgcttgggcg agtggatcgc actggcaggt cacaacactc tgtggcctgtggcaccttct
92821 ccataaaata aggccctgcc ccttggacat gggtggcccc acagagcctcatggagccca
92881 aggcttcctg ctgacagatg gcggaatggg tggaggctct cgggattgtccaggcaggag
92941 gagtccatgt aggactctgg acctggccaa cctgcaggct gaggaggagaaggagaagaa
93001 gaagaagaag aagggcactg cggaggagcc agaggaggag gagccagacgagagcatgct
93061 ggactggtgg tccaagtact ttgcctccat tgacaccatg aaggaggtgagacctcgggt
93121 agggtgaggg gaggtgaccc cctccacact cagaccctcc tgtccagcttctttcccacg
93181 gcccccaaga gctggatccc aactccattc atgtgagttt gggatggttttgtctcacat
93241 ccttgaaatc ctagctcaga actcaccttc caagatgatg gtcccatctaccttccctgc
93301 ttggttttct tttgtcctca ttgactcatt ccacaaatgc ctcttgggtatatgcgatga
93361 gccaggctcc atactaggtg ctatgggagc caaaagatgc cacacctgccctgatgggcc
93421 tccggtttac tgggcaaaat ggacatgtaa acagagactt agagaggactatgtgataac
93481 aaaggcaaat catggcttgg gggaatcagg gaaggcgtct cagaggaggtgacctttgtg
93541 gaaaaggaga aacatgttct cagaggccat aagggaacaa ctgcttatcagtagtcctta
93601 cgactcttct tcataatgtt ttattttaca catcttggtc atcggcacgtgaatgattct
93661 tcccctatta cacatatgtg ggttccatct gtttggccag attgcaagttccagaaagcg
93721 catttctctg ctttcttgtt tgtgtcctct ccacgctgcc tacctagctcagggtgctct
93781 gactggccac ctgaccagga gggacacatg cctgcagttg tgtttcctcagtggggccag
93841 agctgatcca gccacatcct ctcccaggcc ctttctgtga cccaagctaggtgtgatatt
93901 tattagagca cacattaagc tgctgtagca agttagagtg aagtgaacaagacagcagtt
93961 tatttctcac ataacatctc agagagtggg ggttaggctg gtatggtggctcagtggtgt
94021 caaggactaa gatcctgacc tcttgtttgt cacatctgta aggttggaggtgactcaaca
94081 tcatgttcta attcaagtgc acaggaaggg ttaaagagga gatgaggcatatgcttttct
94141 ttttcagggc ccaatccaga agctgcacat atgacttcca ctcacattgatcagaatcta
94201 gtcccttagc tacacttatc tgcaaaggag gctgggaaat gtaatctttcacaaggtggc
94261 tgtgtgctca gcaaaacttg taaaaatagg agaacagatc attgaggacaactggtagtc
94321 tcgtctccca ccatcaagtt ggccaggctg gagctgcaag aggctgcctgttgtcgtctc
94381 tactcctgca attttcacag actgccacca ggtggcggtg gcgacttagttgaaacctgg
94441 tttctagttt ctagtaagat ttattctcgt ttccagtaag atggggtgtgctgagtgaaa
94501 gaaaatatag tacattttct tactgttata cttttgtaca ttaaaacaatttattaatat
94561 cactaaaagc aacattaaaa tgcactgtac ttttttaagt agaaaatgtaaatatttatt
94621 gcaaggtgtt atttcttttt tttttaaatt atactttaag ttctagggtacatgtgcaca
94681 atgtgcaggt ttgttacata tgtatgcatg tgccatgttg gtgtgctacacccattaact
94741 cgtcatttac agtgggtatt gctcctaatg ctatccctcc cctctcccccagcaccacca
94801 caggccccgg tgtgtgatgt tcccctccct gtgtccaagt gttctcattgttcagttccc
94861 tcccatgagt gagaacatgc agtgtttggt tttctgtcct tgtgacagtttcttcagaat
94921 gatggtttct ggcttcatcc atgtccctgc aaaggacatg aactcatccttttttatggc
94981 tgcatagtat tccatggtgt atatgtgcca cagatgcata aacccctaagtaccactagt
95041 cacactgtac acattataaa ctttttttaa cccacttaag cagagcacatggtggacttg
95101 aaatgcagta gggaagattt tctacttcta gtgcattaag actggtctgggcccacaatt
95161 tggggtcaac agactcctcc ccaggaaacc caccttctgt ccttttcatctcatcttttg
95221 gcagcaactt cgacaacaag agccctctgg aattgacttg gaggagaaggaggaagtgga
95281 caataccgag ggtgagccct ggaacctgga actctgcctc ctcctccccgcccctgggtg
95341 gtcagctctc ctgcccacct catcacctgc ttctcttttc cctcctgccagccctcccag
95401 ccttagtagc cagggaagca gcatcagtaa tccatgggca gtactgggcaggctaaggcc
95461 cttgtccagg gaggctttta ctctgaccag ttcagcaccc acagtgatgggcagacattt
95521 agagccacag aacatcagag ctagaaggga cctcagagct cattccatccagcattttcc
95581 agactctttt ccatgaagaa aattgatgga tgttctagaa ggaacaaattagttttggtc
95641 aaattagttt aggaaaagct gattgaaaca gcttgttttg gtgcaggacttttcataccc
95701 tttactgtgc aaatgttatt atacatctct aaaaggaaga cacagtataaaatatttccc
95761 cagcttattg gatcacagta ccctttcttc taaagcatgc cagcagcatctgcaccaggt
95821 gctccactga atgaggtttg ggaaatgcta atacagagtg ttattattatggacaagaag
95881 agggaagcta gtgaggaaag tgagtgggca aggaactgcg cagcaacaggcctccacccc
95941 caaacccatg ctccttcctg cccctctctt ccaaagggca tgaagacagtcttcagacac
96001 cttcccgggc ataaacccac tggggccccc agcacctcca tgaggcgggcatgctaggga
96061 gtattatctg catttgacag cacatggaca tccgagagtt aagttagtaaagcaaattag
96121 cgacagagct gggtctcgaa tccaggcctt cctgctctgc tcatttctgctccacctcct
96181 tttctgcttc tggccaggcc tgaaggggtc aatgaagggc aaggagaaggcaagggctgc
96241 caaagaggag aagaagaaga aaactcagag ctctggctct ggccaggggtccgaggcccc
96301 cgagaagaag aaacccaaga ttgatgagct taaggtgaga gcctaggagcagacccttct
96361 agggtgtgtg ggggcgggaa gaggggggcg cagtgatcct gcaggtggggcaggacaaaa
96421 gccagagacc aggcagccgc cccctaacag cctggtctgt ctcaggtataccccaaagag
96481 ctggagtccg agtttgataa ctttgaggac tggctgcaca ctttcaacttgcttcggggc
96541 aagaccgggg atgatgagga tggctccacc gaggaggagc gcattgtgggacgcttcaag
96601 gtcaggccag gagcacgggc ccagcctgag cacccgccag cccttgccccccccacaggt
96661 tcccccactc acctcccacc actgccccgg ccactgcctc cagaagccctggactctccc
96721 atgactcagc agttaaaggg tgaaggccct gccacatcag ggtccagccctcctggtgct
96781 gttagctatt ttgaatgcca cccttgccag gcaaacctac accctgacccacatttgtct
96841 tgcccagggc tccctctgcg tgtacaaagt gccactccca gaggacgtgtcccgggaagc
96901 cggctacgac tccacctacg gcatgttcca gggcatcccg agcaatgaccccatcaatgt
96961 gctggtccga gtctatgtgg tccgggtgag actcccgtcg ctttccctccttgcaagtct
97021 cctcatcctc ccatctggga gagagcaaag aagctgcata ctggccaggtgcaatggttt
97081 acgcctgtaa tcccagcact ttgggaggcc aaggcaggag gatcacctgaggtcaggagt
97141 tcgagaccag cctggccaac atggttaaac cccgtctcta ctaaaaatacaaaaattagc
97201 caggcacagt gccacgcacc tgtaatccca gctactgagg aggctgaggcaggaaaatcg
97261 cttgaacctg ggaggtggag cttgcagtga gctgagatca cgtcattgcactccagcctg
97321 ggagacagag cgagactctg tctcaaagga aaaaaaaaag aagaagaagctgcatactga
97381 cagccccaga ctgggaggca ccagggagat catttggtct agtctttatcttttctagag
97441 gaagaagtca acgcccagag aggggtagcc acttgcctag ggtcacacagcaagcctcct
97501 gaggggtcca gtgctcctgc ccctgccctt cactgtcata ggaccctcaggcagcctggc
97561 aggggcactg aagatgagca gggcatggga gcctgctcag gcagcccttctccccattcc
97621 aggccacgga cctgcaccct gctgacatca acggcaaagctgacccctacatcgccatcc
97681 ggctaggcaa gactgacatc cgcgacaagg agaactacat ctccaagcagctcaaccctg
97741 tctttgggaa gtaaggcttc ttggtgccct cccctgccac acccctacttctccaaccca
97801 gaacacctcc caccctagcc aatccttaag cccttctcct aactccaccccaccaggtcc
97861 tttgacatcg aggcctcctt ccccatggaa tccatgctga cggtggctgtgtatgactgg
97921 gacctggtgg gcactgatga cctcattggg gaaaccaaga tcgacctggagaaccgcttc
97981 tacagcaagc accgcgccac ctgcggcatc gcccagacct actccacgtatgtggggcat
98041 ggggcagagg gcgggggcag tgtgcctgct ttgcctccac tctaaaatgagattcagatc
98101 ctggtgattt gagaggttag acattgtggt ttctgtccca ggccaggcctctgcccctac
98161 agtccctggg cacagtcttc aggggacagg actgcagatc ccaaaacaaggagagggaca
98221 gtggattcca ggacagagga ggcaggacga ggagagacaa gtgggctagggaaggtgggg
98281 gctagcaaga ggaggacaga aagagtcccc tggggatctg ggccagctctgccacttata
98341 ggctgtgtga ccctggccaa gtcccttcac ctctctggtt ttcagtttcctcatgggagt
98401 ctctgaggtt ccagaggagt gggcacagtg aggggatgca gtggggctaggctggggaca
98461 ctgatatgtg gtccaaggcc cagggcagga aggttcagcc tccagcagccctagtgtctc
98521 aggtgagcct ggggcccagg gcaggaggaa tcaggctcac ttgctgatgagggcaacagc
98581 caactttaga gaactggcca cgaccagctg tcatccagga tggcttagtcccacccagcc
98641 cctccaagcc tgtgtgtccc ctcccacaga catggctaca atatctggcgggaccccatg
98701 aagcccagcc agatcctgac ccgcctctgc aaagacggca aagtggacggcccccacttt
98761 gggccccctg ggagagtgaa ggtggccaac cgcgtcttca ctgggccctctgagattgag
98821 gacgagaacg gtaatggggc actggatgca gccgcctgcc ccctctccagggggtttcag
98881 aggccaggag gggcccacac ttccctgggg aacctcacag cctagcctggggtgtcctca
98941 gcctaaacct ggtcttagtg accctctgct catcacccca gagccccgttcctgtctgcc
99001 cagcctctgt gcttccaccc ctcctacagg gcagccccac ctgctttctctctgtccaaa
99061 tcccagtgag gtagagaggc tatctgcatc ccattctgca gataaacaaaccaagatcct
99121 acttctagtg actcgcccaa ggtcatgtgg ctctttagag gcagagcgagggcatcggcc
99181 caggtccatc tggctctaat ccttaaactc tccttacttc tctgtccatgaggcacttcc
99241 cagagaagca gagaattggg aggtgtctgt gctggtatct gatcactttcaggtgctggg
99301 acaggaagtg gattctcccc tccctgaccc ttctctcagc ccagcagggctctccagtca
99361 acttccccaa gcagaggacc aagggcacag acctctcttg gccctgtggggcagctgaga
99421 ccctgggcaa gccacttctc cttctgtgcc tcagtttccc caacagtgaaaaggaggtgg
99481 ggtagacagg tgatggcata gaggcttctt tgtgctccta agtccctagtcccagcaaag
99541 gtcttctggt tctgctgagc catgtgtgca gctgagccgc cggcacccacaggtcagagg
99601 aagcccacag acgagcatgt ggcgctgttg gccctgaggc actgggaggacatcccccgc
99661 gcaggctgcc gcctggtgcc agagcatgtg gagacgaggc cgctgctcaaccccgacaag
99721 ccgggcatcg agcaggtgac acttgcatgg ccaagactgg ggttcttgggtattggggac
99781 cagggatccc caacctgagt cagtaaaggt agaagccagg cctcacgctgtccgctgcat
99841 tccagaaagc ctggcaggca ccttcccacc aaggcccctc agggtaacttgaatggcaag
99901 ggtctttgct ttgagtgaga attacatcag ctcaggcaga gacctgggttgtctccctca
99961 gaagctgtga ttggctattg gtgacatcat aggaattcct ggcatccaaagatggaaact
100021 gatgaactgg gtccttgaca gaacaaaggt taggagggag aggagagctgatcttcctgg 100081 gcagagggag aaggccctgg gagatctgcc acaaccctct tcctcagggccgcctggagc 100141 tgtgggtgga catgttcccc atggacatgc cagcccctgg gacgcctctggacatctcac 100201 ctcggaagcc caagaagtga gcggcctggg gcccagcgct actcccttccggcccacccc 100261 acccacttcc caccacggcc caacccttcc tgcggggggc tcaggtccagatggccttgg 100321 ccagttggca tccctggggc ctgggtgtgg ccactgggcc ttataggggagaaactgacc 100381 aaccaatcga tagagtttag ggcctgccct ggagagtccc cacgtgctaaggcaggacaa 100441 cgccttccac cctgcatcag tgagcgagac aagccccaca cagcacactccggtgcattg 100501 tatctacacg gtctacgcgc ccatacacat gcatctcatg cacacacacacacacagcat 100561 agcactccca cggacaccca cacacatgcc cacactgacg cactccttcacaacacacag 100621 aacccctggg agccggccct gcgtcatcct cacatccagg ctagtgtgatgttccgccaa 100681 gttttctttg gagtgcctgc cagtgatgaa tccaggagtg agtgcctggaagaggcagga 100741 ggtggtagag tgaaaagaac ccgggtttcc catccataaa gcggcaggttcaagtccagc 100801 tgtcagacag tgactggatt cagggccagc ttcagggatg gaggaagccacacagggtcc 100861 cactcttgtt tccatgctcc tatgttgcca tcttgaaatt ctttatgacaagtgaccctg 100921 catttccatt tggcgctggc cccagcaaat catgcagcaa attctgccaggaatgtcctg 100981 gaaacctgag gccatgagtc agctgttcca gggcctgtca ttagggggcacccaactcac 101041 tgggccactc tgggctcgca gccctgtctg caatcccagg agagccatgctcagatcaat 101101 ttttagtgaa tgactcagcc tcactcttaa tgattgaaat gaactacatcattcataatt 101161 acaattaaac cttgagggga aaatcctctt tggggacagg gacatacagcttccatgggc 101221 ttccattgct ggctactggg cttaaatgca gacttctctt ggaactagcatctgagacag 101281 agggtggctt cctcccctca ccccaccccc accgcccaca gccatgtgcctggtgggcct 101341 tctcactcat gcctctgctc ccccaacccc aaaccactcc tccagccccagcctggccca 101401 ggccctgtgc tgaccccaag accccagggc ttctctccgc ctgccccatcccagccctgg 101461 caccctggca taacccccac ctggggctgc taaccagcct tctctccctgggcccaggta 101521 cgagctgcgg gtcatcatct ggaacacaga tgaggtggtc ttggaggacgacgacttctt 101581 cacaggggag aagtccagtg acatcttcgt gagggggtgg gtgagcagtccctgcatggg 101641 agggactgag ctgggtgggg cttgcttccc ggggggcagg agaggaggcagagggaaggt 101701 ggctgtgggt gggagaggcc ccaccagcct ggctgcgggt ctggagatgtggcgcccaca 101761 ggtggctgaa gggccagcag gaggacaagc aggacacaga cgtccactaccactccctca 101821 ctggcgaggg caacttcaac tggcgctacc tgttcccctt cgactacctggcggcggagg 101881 agaagatcgt catctccaag aaggagtcca tgttctcctg ggacgagaccgagtacaaga 101941 tccccgcgcg gctcaccctg cagatctggg atgcggacca cttctccgctgacgacttcc 102001 tgggtgcaga gcagggcagg gatgggggtt caggatccag aactgagaagaggcaggggc 102061 cgggttggcg gggacaggga gagccctgcc ttggggggac aaggggtcattgcttccagt 102121 ccatcagagc caggggtgtc cgacggggtt ccgcccccaa ggacccacctaaccgtccct 102181 aggcagatgt tctcagtgtc ataaccaggc tgacaacaag ctttggacacaccaaggagg 102241 gggcagtcag tgatgatggg ggaggggaga ggctccctaa gggagtcgggaaacctccct 102301 gggcctcagg ttgcttctct gtaaagcagg gattctccct aaaactctaatctgcatctg 102361 caaaagcttg tgggattagc aggactttga cagaatggat gcatggcagggagtggcagg 102421 ggagacccca ggagagaccc tctggggtga aagaaggacc tgagtaaagcatgggggctg 102481 gggctgccta gcaagcccac gaggatgcct gcattgaggc cagttgctgggagtgaggca102541 ggaggatgag atgtgggctc agggaggtct gcactcagca aacaaggggccgaggagccc 102601 agacccccac ccccaccccg ccccacccca gccctgttca ctctgagctgacactgaggt 102661 tgccacaggg gccatcgagc tggacctgaa ccggttcccg cggggcgcaaagacagccaa 102721 gcagtgcacc atggagatgg ccaccgggga ggtggacgtg cccctcgtgtccatcttcaa 102781 gcaaaagcgc gtcaaaggct ggtggcccct cctggcccgc aatgagaacgatgagtttga 102841 gctcacggtg cgcacccctt cctgctcggg cagtaggcag ggctgggactggctggggtg 102901 ccaagggccc agcacgcagc ctggacgctg ggacctgtct gtcctctgcagggcaaggtg 102961 gaggctgagc tgcatttact gacagcagag gaggcagaga agaacccagtgggcctggcc 103021 cgcaatgaac ctgaccccct agagaaaccc aagtgagtgc cctgccggcccagcccctcc 103081 ccactctggc tcttggaggc gctggaacag gaaggagacg atccccagacaccccatctc 103141 ttcctgggcc acagcctcat tacaggggag cctcctccct gccctctgccaaccctgaat 103201 cccacaacgt ccctttgaac cagaggatgg gctaggaata ctggagagcaggaccttccc 103261 tgggaaaggc cccatctagc ggagagaaac tatgctcttc ccttcctagcttttgcagaa 103321 gagccagctc cagtggtggc ctctggggcc atggccagcc ttgatggccagaggggtgcc 103381 tagaactgca cacacagccc aggacagctt ccctcttggt cttggcccctcgccacaccc 103441 aatcccttct cctccctgtc cctcctctgc gctctctacc cttcatactccagccggccc 103501 gacacgagct tcatctggtt cctgaaccct ctcaagtcgg ctcgctacttcttgtggcac 103561 acgtatcgct ggctgctcct caaactgttg ctgctcctgc tgctgctcctcctcctcgcc 103621 ctgttcctct actctgtgcc tggctacctg gtcaagaaaa tcctcggggcctgagcccag 103681 tggcctcctg ggtctgatat ttcttacttc ttcctctgga ccaagggctaggcaggcgcg 103741 tgcacacaca cacatataca cgcacacatc cacaaacaca aatatgcatacatgtgcaca 103801 caaacacaca caagcatgta tgcacacatg tgccacgcac aagtgcatacacatgcactc 103861 aagcacacac aggcacacac ttaagcccac acaaacatgc acagcaactttcaagctttc 103921 atgacagaat agactctcag aactagaaat gactatttta cacttttccacattaagcca 103981 aagaggtgaa gtagcttgct caaggttacc cagcaaatta gggtagagccgggactcaag 104041 ccaaggtttc caaatttcca atcctgtgtt ctttgcacac cacctctgctcccagccatg 104101 tttctcccag actgtaaccc aatttttttt tttttttttt ttttttggagacagagtctc 104161 gctctgtcgc ccaggctaga gtgcagtggc acaatcttgg ctcactgccagctccgcctc 104221 ccgggttcac gccattctcc tgcctcagcc tcctgagtag ctgggactacaggcacccgc 104281 caccacgcct ggataatttt ttgtattttt agtagagacg gggtttcactgtgttagcca 104341 ggatggtctc gatctcctga cctcgtgatc cgcccatctc ggcctcccaaagtgctggga 104401 ttacaggcgt gagccaccgc gcccagccga ctctaaccca atttcattggcagaaagaag 104461 ctgagctatg gacagggaaa agggaagggt gtggccaggg ttagccaacaggtctggaaa 104521 tggctctcac ccgtgtgtga cctcccagtc cagggctgtt gttttctgcccttcaggata 104581 ataattccat tcaactcaaa catttcatag ccaccatggc ctgaacacccaactgcaggt 104641 gctcagagct ccccaggcac tggctcactg tgccattgcg ccaaacccaggaggtaggta 104701 ctgcttgtaa ccccatttta tacatgaaga aaccgaggtt gatagaggtgcctcacttgc 104761 ctgtgaaaac cattcaaaac caggtgccct gcacccaagc cccggctctgtgtccccacc 104821 aatactgagc tcagctctgg ggctgcacgc catgtcctct gggaggcagtagtttgaaaa 104881 tgcatatgca gtactttcac ttgtatcttg acattttaca aaacctattgtttttataac 104941 acaaacgaca gatagtgagg ctggccaggt gcttctcggc tgggaggctctacagaaggt 105001 ggagtgggtc ttcatcctga gagtgggcag gtcggtgagg gcagcttgcaccccacaggg 105061 gctgctcaga ccctcagcag ggcccggtgg gaacagccat ttatgtccatcagaaaggaa 105121 gaggttgtga agcaccagtc ttaccaagga cgtggggcag cacatagaacgagctaaccg 105181 caggagcttc ctaacgatga gaactgcctg cagggccaag gctgccccatgctgcaagta 105241 gctcccatct aggccttagg aggagattcg ggccccaaag gtgctgcagggaggatagag 105301 ttttgtaagc agcaagtcgg gtacttagaa atgggtttaa accctggctccagcattcac 105361 tgcttttggg gctggggcca tggcagggct tttgggggtc cagaaggacagaggatgggg 105421 tgcactggga ggcagctcct gcccactggc tgaccggctc ctctcttccacttcccagcc 105481 ggcccgacac ggccttcgtc tggttcctca accctctcaa gtccatcaagtacctcatct 105541 gcacccggta caagtggctc atcatcaaga tcgtgctggc gctgttggggctgctcatgt 105601 tggggctctt cctctacagc ctccctggct acatggtcaa aaagctccttggggcatgaa 105661 ggccgccagc tcccgccagc cgctccccag ccctgccgca tttcctttcagtggcttgga 105721 ctctttccca tctcccctgg ggagcctgag gagcccagcg tccactcttcatgccttggg 105781 ccgagcctgc ctcctgcttg cgggggccgc ctgtcctcac tgccccaggctgcggcttgc 105841 ccagtcccgc ccctctgacc cctgcctgtg ggctggggag ccttggatggggtggggacc 105901 tggaatgggt ctctcttgcc ccacctggct gaggcgccac ccttcttcaggcccaggctc 105961 cagaggaaga ctcctgaaac cctccccagg tcttccaagt acaggattgaagctttagtg 106021 aaattaacca aggaccatgg gtcagtgccc agggctttaa aaagaatgaacgagcaaaag 106081 gtatccccgc cgtgacccct gcagatagca ccggtctttg atccgcagcaggggccagac 106141 cctgcccaca agtcccagcg cggctgcttc tgccactgct gggctccacttggctcctct 106201 cacttcccag ggggtcgcct gtcctgcctg tgggtttcca tggcttcccagagctccctc 106261 tgccccagcc agcgcctcca ggcccagctg aggagctgtg agaagcagcagaggggactc 106321 cccatcccgg gcacaccctg tcctcccacc cctgccccct tgcccttccagccctttcag 106381 ctgcagctgg gagctggccc gtcaagtgct gcccctgcct gtgtctgggtttctgttggc 106441 tgtttttctt ttcttgagtg gtgatttttc tctaaataaa agaagtcaagcactgagctg 106501 acaggtctgc actggtcaag ctgagaggag cagccgcagg tgcggggcagaggcagcagt 106561 tctctaggct ggcagattca gtaccagcag ggctcccatg gcctttccccttcaagtggc 106621 ctctggtggc ccagggttca aggcaggcct caggcacagg gctgcccacccaggctgccc 106681 acaggaggag tcttacacca tagcccaaag ggcacaccag cctgggcccaggggccccca 106741 aagcaccgaa agaatccttc aggtctgggg ccagtctgaa ggcttaaggccccacaaggg 106801 cccaaaagct ctagcctcca cccacagaaa ccagttcccc tgaaagcaagaaaggagccc 106861 cacgctactg gcctcggcct ctgactcaca ccactatctg agcctggggcaaagtcccct 106921 catgacacag aggtaggggc aagggcctgg tcttgctaga cctgacctctttaaagagat 106981 tcagccacaa ctttaaaagg ctttaatcat aatgcaggac acaggtaactcctctggctc 107041 cttatttcga caggctataa agacagccct ggaaaatcca gagagcaggcccaggtgcgg 107101 cccagtgggt gatatgagct ggctccggca cagacaccag catcaggccagccctaacac 107161 atcagccttt ggcggtccag ctcattttgt gggtacccgc aacacctgagtgggaggaac 107221 ttgcagttca gagttgatct ggaaaagaaa gggtgaaagt cgttacatttttcccagggc 107281 cctccttctt tgccaccctt gcgagccacg ctggctctcc catgggcctccaaagccctg 107341 cacgcatctc ctctccaaag ctgagagatg ctgaacaccc acagactgcctccctgcagg 107401 agacacgcct gagccttctt gctcagcttc tgctccagct gtgacctctggtagcgttct 107461 tcatctcccg cccgtccatt ctctgcagtc ttcccctctc ctctctccacgcacccatgc 107521 catccccaat ctagcctgcc ccacctcttc ctcccccagc ctcttgtatacagtagcatc 107581 tgtggaagcg ggaaccatac cgtccagaat gtctgggtcc tgtcacaggccaagggtcat 107641 tatgaggcca aggttcacta caacatccca ctttcagctg tggcctgggacctgggactg 107701 tgctggggcc acgcagcccc tgtggctgga cttggagctg gcctcagtcacctcacacgt 107761 gtgcaactaa cagctgcgtc acgaccttcc tggcctacag ccccagctgcaggtgcccac 107821 acccgcagag caggaaatgt cagcaatgga ctttttcctt cctcctcttgccaggccatg 107881 gggaagttgt ccacaactat tgcagggttg ggcacagatg ggggccagggaatatctgcc 107941 ccagcagagc ctccttcccc atgcgaggat gaccctccag tcatatcccaggcagggaac 108001 cggggctggt gggtggaaag agcccaggct ctggacgagt tgcaaactctgcaagttgtg 108061 attgtccttt gtgtgaaatg aggagcattg tttccgccct gtccacctcacacagcgggt 108121 gtgaggatgg aagaagagag cacagctgga ggctctgtag ctggggagctgctcctggct 108181 gtggcactgc ttcacacaga gcagtcccag ctggccactg gcaccagaaaccacagtatc 108241 aaagagacac tgtcacacct gagctgtcct ggaggagact tcaggcaagatctactcctt 108301 tggccagtag ttgtctcaag gtgccactct tgatttttta catcatatcacaaagctccc 108361 ttgcctctga cggggagggg actcctcgtt ccctaatccc agctccagtgcccctgcccc 108421 acccgtgtct cccgctgccc ctccttggaa ggccccgccg cccaccttggagttcagata 108481 ctgctgcagt agcgcc
Norrin胱氨酸结生长因子(NDP)
NDP基因编码“norrin胱氨酸结生长因子”(NDP)。人ND基因位于染色体Xp11.3上。其包含3个外显子，涵盖约千碱基(kb)(NCBI登录号NG_009832.1)。NDP编码分泌的norrin蛋白，所述蛋白在通过(FZDA)和(LRP5)共受体的Wnt信号传导路径的视网膜血管生成中发挥作用。NDP中的突变与诺里病(Norrie disease)假性神经胶质瘤(一种特征在于儿童早期视网膜病变的X连锁隐性综合征性听力损失)相关联。约有三分之一的诺里病患者会发展为进行性听力损失，超过一半的人会经历运动技能的发育迟缓。
NDP基因中的各种突变与听力损失(例如，诺里病假性神经胶质瘤)相关联。例如，p.His4ArgfsX21、p.Asp23GlufsX9、p.Arg38Cys、p.Ile48ValfsX55、p.His50Asp、p.Ser57*、p.Cys93Arg、p.Lys104Gln、p.Gly113Asp、p.Arg121Gln和p.Cys126Arg突变各自均与诺里病假性神经胶质瘤相关联。参见，例如，Musada等人，Mol.Vis.22:491-502,2016；Chamney等人，Eye(Lond)25(12):1658,2011；Liu等人，J Chin.Med.Assoc.79(11):633-638,2016；和Parzefall等人，Audiol.Neurootol.19(3):203-209,2014。
检测基因中的突变的方法是本领域公知的。此类技术的非限制性实例包括：实时聚合酶链式反应(RT-PCR)、PCR、测序、Southern印迹和Northern印迹。
示例性人野生型NDP蛋白为或包括SEQ ID NO:20、SEQ ID NO:21、SEQ ID NO:25、SEQ ID NO:26或SEQ ID NO:27的序列。编码野生型NDP蛋白的核酸的非限制性实例为或包括SEQ ID NO:21、SEQ ID NO:22或SEQ ID NO:24。如本领域中可以理解的，可对SEQ ID NO:21、SEQ ID NO:22或SEQ ID NO:24中的至少一些或全部密码子进行密码子优化以允许在非人类哺乳动物中的最佳表达。
人成熟NDP蛋白(SEQ ID NO:20)(NCBI登录号NP_000257.1)
MKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS
人成熟NDP cDNA(SEQ ID NO:21)
atgaaaacggacagctcattcataatggactcggaccctcgacgctgcatgaggcaccactatgtggattctatcagtcacccattgtacaagtgtagctcaaagatggtgctcctggccaggtgcgaggggcactgcagccaggcgtcacgctccgagcctttggtgtcgttcagcactgtcctcaagcaacccttccgttcctcctgtcactgctgccggccccagacttccaagctgaaggcactgcggctgcgatgctcagggggcatgcgactcactgccacctaccggtacatcctctcctgtcactgcgaggaatgcaattcc
人野生型NDP基因组DNA序列的非限制性实例是SEQ ID NO:22。SEQ ID NO:22中的外显子是：核苷酸位置1-87(外显子1)；核苷酸位置88-468(外显子2)和核苷酸位置469-1719(外显子3)。
人NDP基因序列(SEQ ID NO:22)(NCBI参考序列：NG_009832.1)
1 aagatgctcc gtggaaggga gccgagcggt gggcagaggc tgagtccccg ataacgagcg
61 cctcacattt ccgtggcatt cccatttgct agtgcgctgc tgcggccgca cgcctgattg
121 atatatgact gcaatggcac ttttccattt gacattctct ctctctctct ccctctctct
181 ctctccctct ctctctccct ctctctctct ccctgtgtcg cttaaacaac agtcctaact
241 tttgtgtgtt gcaaatataa aaggcaagcc atgtgacaga gggacagaag aacaaaagca
301 tttggaagta acaggacctc tttctagctc tcagaaaagt ctgagaagaa aggagccctg
361 cgttccccta aggtaagcag gaaaacaagc gctgccggct tgcctaggaa atcgcttctt
421 tccaaaccga gcatttcatc ctcctctcag acaaagagac aacctttaaa taccacttaa
481 atttgcatta ctttaatttg cattaatctg tagcatgcta gcattgtgtt tcttaaatga
541 acgggtcttt gaagtctgtg acagagcagg gagcctccta gaaaagcttg aaaatatctt
601 ttggtttgac ttaaagagat ttttcttttc aaactctctg cgtagttaga tgtaactttg
661 tgatggttct tatagttgac cccgtgaaag ggggctgcga agcagcaact tgccaacatg
721 gattcatgga gcccagtatc ttccccagca ccctcatccc acttacaatg ggggcactat
781 taacgcaggc aagactgcga gtttaaaagc gcactgttta cttttattac tacttatgta
841 tgctgctgat ctcctgccag ggctctgccg gagtgctcag aatgacttca aacaataggc
901 aacatttatt tctagctttc tgtgtcacgc tttgcaggaa tcctgctccc ttgcactctt
961 ctttcagcgt gcaggtcttc gcttccatag atgcattggg gagcaccggg aggagatgag
1021 gatggattta ctgtatgatt ttgattgggc aaaaagtccg aggaaatgcatgctgtttgc
1081 cttggactta ttgcaggggg ttatttttag tcatcagctc gtccctgcagcatgatgttc
1141 aaggagtgac cgggaaagga tgctcccacc agcacagaga ccaggacctgtaggaatgac
1201 tcctacctgc gggatattcc gaggtttctt tcaaactttg gaatacaagttctctcttta
1261 aatgaacaat tgagctgtag gaggcctggg cataactctt tcttgggggacgggaagttt
1321 gattgtgtac agaatgttaa tgactcagaa cgcccagtaa ctgaggctcattgtaataga
1381 caaacccaga taagcctcca tgagaggcag actcccatct ttactgagattcaggtgcgg
1441 gaaaggaagc tatttggcaa gatgggagtc ccttgtacag ttctttgtaactcattaata
1501 acagatatgg ctgctgtgaa acatgtctct tttcatttct aatattagtgtattttaatt
1561 acaaggagct ggcattggca aattacccca acacataaga ttaaataccaggtgcatttg
1621 aaaacagaga gatgactgaa atggggagtt gctgtgggtg tcaaccaaatacagcgggga
1681 cggcacaatg cttctcaact gagcgtttaa accagatgca aatatctgctcattttcttc
1741 tcatcagtct tactaattca aggaaacttt atggtcctgt ttgccagttttcattgcaaa
1801 ttggtacaca gtttatgcaa aacttttctg attttctctg ataaccagcccaataagcat
1861 cgctgaatga aaatctgata tttgaatagg ttaatttaca actttggggtattcattagt
1921 caagaaagcc ataaaagaca ctatggattc cattgctgta aaattttattgtaatttttt
1981 tttaaaaaaa ctgcggttag caaagcattt agctgaatca aaacaattttcttagactat
2041 tattcagatc attacatgag agtatttgaa cacaaaatgc aatgttttgcatcatttatt
2101 ttaaaataca tttggttcag gtaacgggag aactggctga ggccttcttacgactgtgta
2161 ccaagcagct gacacccaca gatggaaatg tgcctgtgga gttttcaatcttaattcgag
2221 ttccaatgac actgtcaagg gaaaaataaa tcatttttca atacatttaacaatttccaa
2281 ctcatttatt ttcctgggcc cttgaaaaat gtggtgagtt tcttggaattatagccacca
2341 atggtggcca gcaatcttta ttttaagaac tcacaattca agtactattattctctggtt
2401 aattatttat ttcatcaatt tttaaataaa tatttattaa gcattttctagatgcccagt
2461 gctatgctag tcccgatgga tgcaaaggtg aatgagacat tgtcccatactctaattctc
2521 agtccatatg ccatctctag ttagattttg gaactgaaat gggcattgccaatgggtaaa
2581 gtgggcaata actttcctgt tataaagaat tatttaaaac agctactggtttctagattt
2641 acttgaaatg attctcactc atcagtgggt tttctttcca tttatgattaagggattccc
2701 ctttggcctt tttcaccaga tcctgggtac acgtcatttg cacagctaacacggctagat
2761 ctttccagcc tgggtagaag aatcccggaa aaagacagta gtttatcctttctctgctct
2821 cctgagcacc ctgtggaaag gaccatatgc tgtctctatt ggggatgggtgtgagtcgcc
2881 tactcagtag ctaacatcag ggccacttga tgaatcatcg aattagaaacatgcatatgg
2941 aggaagatgc agtcactatc cctcaccact tacttgtccc acccccagtatcaaaacaaa
3001 tgacctctgg gcctggccta aattcaagag gcccctggga agaagctgttggaaactctt
3061 ccccaaaccc aggtctccat catagccaca cagtgttgct ttcaaataacccagtatggt
3121 gttttatcac gtgtttaggt tactggggga aaaaaaaaac cctgaaaacagcatcaccag
3181 ggtccttgac ttggtcctta tcagcagata atcccccgtg gttggattaaaatgcctctg
3241 actccctggg gtgcctgact caccctagcc agccctcagc ttcttggccagcggccttcg
3301 agcccatcct cacctcttcc catgacggcc agtgactgct tctttgcccaggccctctgc
3361 actaggccag cagccagtgg gagcagaggg gatgggaagg caggtggacagactgtgaag
3421 tgctaaggca gagcggggaa gcagggctgt gagacagggt gggtgagctccagggcctgg
3481 gttgctgtgg cctgccctgg ctgtgatcag ctgtcatttc ctctttgtgtatgacactgt
3541 ggaacatatt aaaatttctc tgggatggta tgtttggaat tcctctgatgccccacctca
3601 ccaacttacc cggacaataa aagcaaggtt gtaagccttt gaacagctggctggctatat
3661 atttcccttc tttctttcgc ataatctaat tcagaaaaga atccagctagactggcagtg
3721 ccatgtctgg gtacttgttt cctgcaagtc cttcctcctc cacctcctcccgccagtcct
3781 ggaatcttcc tgggtggcat gtggcttttc ttttcttttg ctcaccactgctcccagccc
3841 gccccctttt cccttcgcct gagctccttc ctttgtcagc tggctctttgctctgcctgt
3901 tttccagaca gcttgggtcc tgttccatcc ggggagaaca gcccatgggatctccccatc
3961 tccatagtat tcccaggatg tcattcttgg caccagctct gccgggctgataggactggg
4021 gggctttttg tagtcccgag cctgaatcca ctcacagaga ggagcagccacatggcttag
4081 ctgccctttg ggctgccgag agcggggctg gagtgaccgg gttggcaggaacgagcatac
4141 catcacagtg acccgaacat ctccggcaaa ggccttgggg tgggagcgctatgggaatgc
4201 ctggatgcac ttcggcctac attaagagaa atgtggttat tctctgtttcgggggagaga
4261 caagcggctt gaaacaaagc cctctggatc cttggcccct tccctgccccctttcccggt
4321 ctgtccttcc cacatccctc cctccccaaa cagaaagaaa gagagacaggacttctaatt
4381 tggccagcac agacccgaat gtctttatga aacccattta gtgaaagaaagaggggagaa
4441 atatattctg ggttgatccg aactaaaaaa tgcatggggc tttggagatggggcgggatt
4501 ttttctttct ttctttctgt ctcttaagag cagaacaaca gtttcgttgatgagttgcaa
4561 atggaaggaa gtggacctct caattagaga ttcccattta agagcctcaatgtaaacctc
4621 cctgtgacat ccttaaaaga tgctgctaat gtccctggga ccaaaaggtattaaacagca
4681 agccaccagg cggcttccta ttccttttct ttttctgggg gctttggtcgtctttttcaa
4741 attagctaaa attcattaaa ggacccaaaa ggaaaaattt aaagcagctgaattaaaatg
4801 agtctttccc tgttagcctg acaagaagaa aaaaagaaag gaagaaagggaaagaaagag
4861 aagaaagaac caattcccct ccactaccac ttcttgggtt ttaatatgaattattccata
4921 caagtcccta ggctagagga tctatttaaa gacgcctggc agcatgaagggagagggtaa
4981 aaatacaacc actcttttgt ccatcaaagg ttttctttgg gaggacattaagagcattcc
5041 tgttttcttg tctgcccctg ccagtggcaa tgttccagct ggtagtatccactcctcgcc
5101 catcaggtca gcaatcatga acttctgtgt ttaatttcag gagaaaacaaagggtgggaa
5161 atccttccga aacccctatg tgtgtgcagc agggcagggg aggctggaactggaatcagt
5221 actctcttgg ctgtgcaggt tgcatgctgc aaattcacac acccacacagttgagttgtt
5281 gaggaagatt gtgccgatgg cattatttct gatgccagct tcccttgcatctgcaaagct
5341 tttttcttgt gtctctggca gtcatttgct tgtcaccatt catgtgcactgtccccttca
5401 tcagaggttc tcagagcctg atggtcaagg atatgtcact agagtcttacccccagaccc
5461 attttcaaca gtaagaacgt gaaaccctgg atggggtttg caatctgaagcaactacttt
5521 cttgttagga agagtgctga ctcagaaaat tcaaagaatg ggtaacttccgttggcgaca
5581 tatccccagt gctcataatc aggaattcat ccagttgggg tccatttcaccctcatggca
5641 aaatctggac ataaacattg actagtagct ttaaactggg tataagatttgcaacagata
5701 acatttttgt cttttctttt ttcttttttt tttccacaaa agctaagaatttttcagaca
5761 atttgctctc ttccaaggcc tggatcaatc ccaacttttt cttttaagccatgatccaac
5821 caattgcagt atcctttaaa aatgaaaggg caacaggcta agacattcaagaaagttgat
5881 aagctgtcag aaaatgctca agggtggcct ttctacagtg ccacaaaccaacaacagccc
5941 taaacgtgga gtcctcttcc atcctttcat cagtagggaa taaaaatagggagagagcag
6001 gtcaggggag aagtaacaaa agagaagtaa gaaggattat ttttgatgttcaaaatctgc
6061 tgctgccctt tcaatatttt caaatatcac aatttcagaa agggaaggatccctttattt
6121 cacccactct ccctcccagg aaggtgtttg aagttgctgt ctttacctgaaaaggaggtc
6181 aactcctcaa gtgaaaaaac atcccctatc ttcaactcga agtaaaatggaggtacacac
6241 atttgtacct aattatgtgg gtacaaatat aatttgtatc cacaaactataaaggatgta
6301 aagaatcaaa gaaatccaat ccttaatcaa agtccaattt ttctttaaaacttgagagga
6361 tattttaggg ctcattgcat tgctgtgatt tcactgcccc ccaccaaattatgaaaaatt
6421 actccttttc agaatttaaa tttttctttt gagatgtgga atccaaaggcagcagaatag
6481 tattgttaca gggaagctgg cagtcaaaag acatagacat agctgcagcatgcatggttt
6541 aagcaaatca agacaagcag aaaaccacca ccccaacaag ttcagggttatcagcaatat
6601 agggacacgt atttttatgt gatttttatg agaaccttgc ccctttgacatatgtctgag
6661 tctaggagca ttccggattg caacgggatt gaattcagta ttcaaatcccaccattgggc
6721 agaaaaggca aattgaatgg ggaatggaaa gactgagttg ctcctattgtttatgcccca
6781 ttcctaacta agggctctac agctgttagg tgagatcact acccaccattccaaagtgtt
6841 gttgcgggtg aggaggttca aacgcagctt tggaaacact ttgctgcactctttgaagaa
6901 aggccaacat gctcatttgg ctctagggta aaagagagcc tgtaccctgagctaacattg
6961 gtcacctctc ctcctgaggc cataccacag ccagcagtac agcagcagaacaagtgttta
7021 gttgtttcag cacaggtatc cccagaacac ctggcacctt ttcttttccacagggagaat
7081 gtacattcat gcattttggc aagactgagt cctctgagtt gggtgtctcggaactctcct
7141 attttccttc taaagggtct tatgtaaggt gagcagtaga gtgtgtctcattcctcataa
7201 aaaatcccct tcctgggagg gagtgggtga aatgaaggga tccttccctgactgaaattg
7261 tgctatttga aaaaattgaa agggcagtgg cagattttga acttcaaaatgaatccttcc
7321 tcctcctcct cctcttttgt tacttctccc atgacctgct ctctccctactttaattccc
7381 cattgaagaa aggatagaag aggactctgt gtttagggct actgttgatttgtggcacta
7441 tagaaaggcc acccctaagc attttctgac agctcatccc catctcagtcacagctttta
7501 tttgggtagc tggatttaca gaaataatca aatccctaga ggaaaagacttcaacagaaa
7561 agtacctcct gacacttggg taacctgact tggtcatttc caatttatgcaagatttgta
7621 ttctaaaagt caattagtta tgtcaactgt taaaaactca gaatgagtctttccattctt
7681 cagaatgact cttttctgat tatctgtggg ccatagaagc ccacagatactcagcacagg
7741 atccaagtgc cataccaagt ggtcaactct tttagacgta agtctcagcccagggcttct
7801 ggaatgtacc tcccctagca gagaagctct gtagtagata ctttaccaagcacagggcct
7861 cgctcttgac cccaagacta ctgattctac ttgcagagaa gacaacttttctaatcaatc
7921 tttctcttct atcctgaacc agagtatcag agattgtccc attagggcacgaggatctgt
7981 ggctcaagct cagttaagaa ataagcgtct ttcaaaagaa aggtgcaagagggtggaact
8041 cagcctatat tgtcattatc aaatgcaaga agtctaatcc tagcatgatttattaatatt
8101 agcctttctt ctctccccgt ttatgctttg gtgggtactg gacagaaaccccacaaattt
8161 taagacagtt ttaagagaaa tagtaactgg ttaaatatcc tcactacttcaaattattat
8221 tattattatt gatattactg ttaacttttg tttttttgag acagggtctcactctgatgc
8281 ccaggctgga gtgcagtgat gcgatcacag cccactgtag gctcaaccacccatgctcag
8341 gtgatcctcc cacctcaacc tcccaagtag ctgggatgac aagcgtgtaccaccatgcct
8401 ggctagtatt tttttattat ttttgtagag atgaagtctc cctgtgttacccaggatgat
8461 cttgaactcc tgggcttaag tgatcctccc aacactgcct tctaaagtgctgggtttaca
8521 ggcatgagcc gctgcacttg gcccacttcc tatgattaac aggatattattaatttagaa
8581 actatttagt acatggcaag cactcagtca aatggttatt aacggctgtttttatttcag
8641 gccaccaata tagcttcatc aaggggcaaa tacttatagc ttgggcttcagtgttggatc
8701 agacaccacc ttagaagttt tttgcaatca ttaactcctt aagtaagaagggaactcttt
8761 ttgtaggatt gctttgggga atatgtagcc ccaaggcagg ggctgtactctgagaagctt
8821 gggtagagtt ggagactgtt agaaatggat agacacataa aagcatttagaccaatctgt
8881 tcattttgca gatgaggaaa ttgagtccta gaaaaggcaa gtgacttgttcaagatcaca
8941 cagccaatga tgggagggta ggactcaggg cttgaggatc agtttcagaatgcagtgaaa
9001 ttgttatccc atatttcttt caaatcagta tagggacacg gaacactaacaacataggcg
9061 accaatgggt ctagggagga aaagatgaaa gctgtaggta agtgggagtttggataacaa
9121 tgagatgttt ttctggagtt cctgacaatg cctgaaaaaa aaagtcaggattttaagctt
9181 cagtcaggct caaggtcgag tcctcccact ccagtccctc ctcagacagtaaaacttttc
9241 aagccaagga catacatata ggtgggggca tttgacagtt ggctcatctccccaccctcc
9301 aaattattta tatttctagt ccttcagttt agcactccta tttaccccaggattgtaatt
9361 cattgcctct ttccctggcc atattcctcc atcctttttg tttctcccatctcttttctt
9421 cctccatcac ccccactgct gagcttggct acacttggct agtagtgcaggttgggagaa
9481 cacagagtcc tatcacagac tggaggacta ttatttaatc acaagaatgttgtctttttt
9541 ctcctaaggt agcactctgg ggacggtcat tgctgtcttt attccctcacccccccacca
9601 cccctgcact ggattagaca catgaaatgt gcctatctct gagatgaaaggagcaagaac
9661 tgcttcctcc ccactgacct tttgcctgcc catccttgga gatacctggagttggcaggc
9721 tggaggccta gcagcatttg cagtcagtgc cgctgcctct gggtcagcccaggcttggct
9781 ccttggctgc tactgatgtg ctgccagcta ggaatattaa aaaccattcattgaacgcac
9841 aggatgcttt ataaaatcca acatgctgtt tacagtttat aaattaactgccttgggaag
9901 aggcatttga cttattctcc aaggcatcta gttgactaga tccaattggaatcctttgag
9961 ttcctgggaa ggggctactt aacacttcac actttctaaa ttagacctagagtttcttgc
10021 ttttctgatc ctagtactgt atgaagtttt atctagggtt atctagcaagctttcttcca
10081 cttataaatc tttgatgttt ttgcaatttc tttgatagag gctttatgttctactatctt
10141 cactttattt atgcttcata ccataatttt ttaaaaaatt acaataaatatcaagtaatt
10201 ctggctgata tactgactcc attccaaggt cattatattt tatttgcttaacttggtctt
10261 cttagaaatg atgcaatgaa tactggatac aaattagatg ttcagagagtttatcaatgt
10321 gtctaaaaac catccaggaa aacaacaggc caagactctg cctgcagagtcagtgagcta
10381 gaagagggat cgaggatagg aactatattt ttcccctgac cctatctcttatctgctaga
10441 gcaaaaggag acacacagta ggtgctcaat aaatacatgt taaaaaatatttgttgaaag
10501 aagccacaga agggaatatc agtatacatt agtattgaaa acagcctagggggaaatatg
10561 gatactgaag caccaccctc ctgtgcctgg caagcaaggc aagaataaggccattcttgg
10621 cacataccac ttagcctgtt gctgagataa cttgcgtgaa accagcactttaccctctgc
10681 cagccagaag gtcagcccaa gagtgagctg atctgtgggc acaacaccatctctcaccca
10741 ggaggctggg cccgctgtaa gctctgctat attatttccc tgaggatgacaggtggggaa
10801 atctgggcac cagttgttct tttccactgg tatcatttgg aaggtagctccaaagtcggg
10861 cacgccagcc tacgtgcctc tcctgccggc agaggctcca cattggagctattagaatgt
10921 gggctctgta cgtcggccaa gtccatgtct cagagactgt atccagagcatagcgtggcc
10981 acagggctac tgagttcagc aagagagtca ttctcttgtt caatccattattgcctgggc
11041 caaggttcta agtcttcgta ggcagcattt gattttatga cacgtcttaaaaaattaagg
11101 caaactggaa ttaatttagt tttgagaaaa caacagaagc tgctacaaggcagagataat
11161 tctaggctgc cagaaagtgg tgatctcagt ggtgtacatt ttcttaattcctgattttcc
11221 tctttgtgag gtcttcctcc cactcccata ctttgcacat tctcacctatgcacaccctg
11281 agcaacacaa tgttgacaac ttgacttagc attgctcttt tcttaagctttgttttcatt
11341 tcttcttcaa tacaacagtg ttggttcatt caatttgaac actcaaggcaaaaaaaaaaa
11401 aaaaaatccc aggttatgtt ttcagaatct tacctttttg tttttgttttgagggttctg
11461 tgagttttgt ggcatattta cattgttgct tacattctta tttcagaatttaagataaaa
11521 actgggcaac aactctcacg ttttctgagt gtgttgaaat gaaaaatctgtttcttagaa
11581 ttaatggtaa agcaacattt cctgtcaatc tttcattctt taatattacttctgggttca
11641 gctcaccatc tctaaagaga aagccagatg atcaagttac attgtatgtgacattaacta
11701 tctctttatc tgtgtaaatg tcataatatc tgcttgcaaa gtgttttattcatttttagg
11761 aaaaaatttt aaactgtgct tgcaattcag gatggtgcta ctaggtggcagtaatgtaca
11821 agaactatgt ggtcgccctg gaagagtatt tgactaagag actagcatgccttcccgtaa
11881 ttataagaaa taaaaatata atatttttaa aatactcaaa ctggcacaaacagtaaacat
11941 ccattaactt agttaccata tttaagctga gcttttaaaa gagaaagccttattttttaa
12001 tgaaatttta aataaagtat acattcacaa gctcaaaaat ctaaaaatacgaaaagatat
12061 atagtgaaaa gtctttctct catgcctgtc cctcaactac cacaggtaactaattttgtt
12121 agtttcttgg gtatcctttc agagctttgc tatacaaata tgtgtttttatctctctcca
12181 ttttaactca aatcaataca tagagtttct gcatccttcc atatatagttggttagtata
12241 ttgttgtgtg aacattttag aatataatta accagtcccc tattaatggatatttcatgc
12301 tgtttccaat tttatgctat ttcagccatg tgctcatgtg atttcacatgtaggataatt
12361 cacagaagtg gaattgctgg gtctaaatta tatacatttg catttttaaaaggtattgcc
12421 agattggcct ctacagagtt tggaccaatt tatactgaac tttctccaaaatggacttgt
12481 tttcccacag ccttgccaat agggtgcatg atcagacttc ggaatctttgtaaatctgat
12541 tggttgaaca atgtatttca aagtacttta attttcattc tcttaaatgagacttttatt
12601 ctcttaaatt ctcttctatc tttaagggcc ctttatattt cctttttctgtggagaaagt
12661 ggaaatgcca ataaatacaa cgatgcatac acatgtatag ggttttgttattgatgtagc
12721 ttgtttttgc catcatgctg tacatgatgt tctttaattt gctttgctcatttaaccata
12781 cctcctggcc atggctctga agagaagttg ctggcagtgc agaagaagggccaggactgg
12841 aatgtctgct tctctcttca tccttttgcc attgactcct gggggaaatatctgtagacc
12901 gaagcagtga aatctaatca attctctttc tgacactaat taaggcttcaaagagacaga
12961 taaccacttg ggataattta gtcacagtga aacttgggaa atggtcagtaatatttcatc
13021 ctctgaaagt ggaccccaag aaagttctgg ctctttgagt tgttgtcttggtaattttca
13081 gggtaacgtg tataggaaaa cccagattat gcagatgaaa agaaaacaaacatgctcttc
13141 tgcatccttt gcagatttga aactttgggc acaggtttga tttatttcaatgagatgttg
13201 ctattagcat gaacataaag tggtgcaaag ttgtgctgga atatggtctcgtcaactttg
13261 ggctcactgt ctgcatatgg agatgatagt aactgaatcc atagttatcaagtggtggca
13321 ttttagaaca caaagggaca gcagatgcca tctctgtcaa ctccttccctctacagatga
13381 ggaaacttgg gctagaggag gttgaatgac ttgtgtaagg cttccccagctaattaatgg
13441 cagtgccagg actcaagtcc aggtgggttc cctcattact ggtccttgcccttcctgcaa
13501 tttataggac ttccctgagg cacatgtgct gaggctttgc tattgccagggattctgtgc
13561 tctgaaacag ccctatctca cacacccctt tccacttagg atcccctacctcacacttcc
13621 aagacagcta attgaggcta aatgggtctg atgccattct attagtgcaaaataaattgg
13681 cttatgccaa cttgaactcc taatcttgat tttatcaaca ctttgccctgtttattcaga
13741 ctgttcatga gtaggaagtt aaggaaaatg ttgcctatga acaaaatgatcaaactttta
13801 tctgaaatac ctttgaaagt tttcccgaag ctttaattat catgttccttttgttttgga
13861 tgtaatagca ggccctccca attttcctaa atgtttgaaa atatttttgatactttctgt
13921 cttctgttgt ggttaaaaaa aagaaggcac cagtgttggc tatgcctggggagttagtga
13981 ggtaatctgg agagatctct ggaccccagt cctttgtcca agaggtatggtcaaaagaac
14041 aaagcaaatt tcagaaaaac cggtataata tgatcctatt ttaatggtaagtctgttcca
14101 acaactgctt tctttttcga attacaccat gtgcccaggc tacaaaggctctgcagaaat
14161 gtgactctgt tggcaaatac gcgtgtgata ccttaaccat gctggaggccagttagcata
14221 atgtgtattt cagatgcagt ttgtcatcag tgctgggtgc tatggggcttaaaacaaaaa
14281 caggatgagc ctagagcaca gaagtggaaa attaggtggg tgggtgagtatggacttgga
14341 aatggaaaat gtgcttccct gtgggacatg gcttgtgttc attagtgctgacctgcctcc
14401 tctctagccc tgtaagctga cgctgacacc aaagcttgct gagaaactgaatagaccctc
14461 ccgccccgac caaccaagga caaagatgag accacccaat tcggttacgttgttgccaga
14521 acaacatgtt taatctttaa catgggttca aactattctt ggccctaggaacatggactt
14581 cagcaattaa agtcaacatg tgcttccatt aaaccattgt gtccacctccaaatggttat
14641 aaatatgtag cataagctat gggagttggg gtggaatgga tgacagcctttgctaatgac
14701 gctctagaaa ccaatattct cctctcaaaa taacatggaa aaattctacttaatacctcc
14761 tgggttccat tagtggttct gggtaaataa ttctggggaa agtaatttctgttttcattc
14821 cagctgtgca gcagatactg tgatgatgga ttgcaagtgc aaagagtaagacaaaactcc
14881 agcacataaa ggacaatgac aaccagaaag cttcagcccg atcctgccctttccttgaac
14941 gggactggat cctaggaggt gaagccattt ccaatttttt gtcctctgcctccctctgct
15001 gttcttctag agaagttttt ccttacaaca atgagaaaac atgtactagctgcatccttt
15061 tctatgctct ccctgctggt gataatggga gatacagaca gtaaaacggacagctcattc
15121 ataatggact cggaccctcg acgctgcatg aggcaccact atgtggattctatcagtcac
15181 ccattgtaca agtgtagctc aaaggtaaga ccaaggtctc tgtgaggagagcatttccct
15241 cagaaacagg caagaagcca tatttctttg tcaggggatg gagaactaagatcatagccc
15301 aaacttaagt gatgtggctg gcccacaggg cttgtgggag aatgaggcttttagaatttc
15361 cccccgtgct ttgcactgtt atcagtaaaa gtgcctaatc aatcatgtgcacacccatcc
15421 agtgggacag gtgtcctttg tccctggctg tgatgtttat gagtggtagtgtgcttttcc
15481 aaaaaagaaa aatggagttt acaagtcatc ataactctct agctccatcatcaataaaga
15541 ggaagagaat gcaaagaatg cgattgagca gtggaacata cttcttggagggctctttaa
15601 agagattctt ggtgaaataa ctggctttgt ggtctgagcc tttcttcaggtgctacattt
15661 ctgttcaaat gatttcaaaa gataagatgg caatatgatc atttatcatttttacattgc
15721 ttatccaaat cgttctcatt tggaaaagga tgcatgtttc ttgcagaggcagtccgtgcc
15781 tcagtggtgt gcaagggaat atcatgctta aaaggccacc aagagtggccagctacatgg
15841 accacccaga agggaggcac attgtagggt ggaacatacg agatctcacgactgtcactg
15901 cccctaaaca ggcacaatga atgaaatttg tccacacttg gtaaataataatttgtttag
15961 cccaacctca gagattttta catttagttt tgagatgaaa atcacttaaacattctcgta
16021 tggcaagtaa tttttgaaat taccagtata attaagaatt ttttatagtatcaatcacca
16081 gaattaagac catataagcc aatccctcca ctctccattc aaaaacattatgacttttgt
16141 atgccttgaa aatttccatt aatttctctg attatagctc agtgatgatgattcatttta
16201 gtttaggagg atcagaattc gagttaaatc attttaacca ttatattaataagatctatg
16261 actgtgggaa aaaatagaga ttttccactt aataaaaact ttctggctcttatttgtgct
16321 tgtagaacca aaaaaaaatg gagtaaatag atgaacataa atttttgcagggccacaatt
16381 ccttcttagg aaagggaaac taaaacaaat tgagaaaaaa catgagaagtgcttttacaa
16441 gtgtgattgc tcagaaattg tgggcccatg taaggttgac tgcagcaattattagtttct
16501 ccttccctcc cccttcagaa acagacagca tgaatattta gtgattttattccatggata
16561 atttctttcc gtattgagtt gtcctccata atcgtgattc ttttttaaaaaaaggaatta
16621 aaattatttc aaagaaagtg tcactatgat gatagaaagg aacaaagaaataggagcatc
16681 tataaaaact agaaaacaat ctggaaagac tggacaaaat gatggaggagtactttggca
16741 acaatcacat taatctagcg aaggtcaaag aagagacatc atgaactcaaaccgaagaaa
16801 ttcacatgtg aattctgagc atgagtctta gaaacagact ttagtgtactgttattcacc
16861 tttgtttctt ccagaaagcc atggcaaata acagcgcaaa attgtgatagcaggagaaat
16921 gtttgtaatt tcatgggaac aatctgtttt caaacatccc aaactatcccaaatatagca
16981 atagttttat gtaaatggtg cttgcaatta taaacctttc ttccctggccataaaatatg
17041 cctggcaaaa tctcaactac ccagaccttt tctaggttag atttttctctatgtatccag
17101 gagcaaaact gttttcattt ggaaatgttc tataattctt aactcttacattctcgggct
17161 gatcttttct ctaatgggtc tcacttaatg aaattgtttg cctttagagacttggataaa
17221 acatttagcc tatgtctaga aaagaggcaa caacaatcta ccctagcttctttttacaaa
17281 gaaaagactg ggatagattt ttttgtctct ataaaaatta tcccttgacatcatgttcaa
17341 gggtcattat ttattaaaca tgtgcctact gtttgcctgc caattgttaatgctttctga
17401 ctcacattta tccattatct ggccttgtaa aggcaagaaa gggagaatgtgacccaggct
17461 cagggaaggg agtgtacctg cttgaacacc taatatatgt gtcaggcacctcatattgta
17521 tattataatc attgccaaga aacctgtgat ggcaggcatt attattcccattatcctggt
17581 aaggaaaact gaagcccaaa ataattagat tgcttgatat catatagccagggagtggca
17641 atgtctgcct tacagcattc atcttcccac tacttggatc ttcatattggaggaacacaa
17701 gtagaatgta ggagccatca catagaagtt caggctctgc ttctgatctgctggcagtaa
17761 taatttatac tcagcaatgt ttctagaaaa aataaataat agtgaaagcctttctgggag
17821 ctttcaatga gactgttcat cccagccctg aacttgcagc tggccagtcctaggtccctg
17881 ctgcccatct cctagcaatt ccggaaagga ctgagaggga gtcaggcagaaaagactggc
17941 cacagtggcc caccaaagag gacagtgtgg ccacagatta ggatgtgcctgatagtttta
18001 agtggtggca cctcctgggt ttgggtacaa aagatcctgg gagtagcaggttcatttata
18061 atcttcatgg aagactaagt ttctctaaaa tttggagtaa aggctgtagagcaaacaggc
18121 aaaagaccag ttgatagtgg aaacagactg cctggtggaa tctctatgagaactgaggca
18181 tgccaggctt tgaagtgaga gagacctggt ttccaattcc agctccatggcttgccgaat
18241 gagtgacttt gaggaagttc agtaacttcc ttctttgtgc ctcagtttcttcccatgcaa
18301 aatagagctg tctacctgag ggtatgggta tgggtgttgg tgatttgtaaagcatccagc
18361 ggtgtccagc acataatagc catttaatag aagatattat gatcttgatgataaagttat
18421 aaactaagca ggtgtttaga ctcaattttc tatttcagtc acaactgagatctcaataac
18481 tgctgggatc tcctatagcc ttaaaagatt aggaaaatga accttattgtagttcttgtt
18541 aagcacaggg tggggcagaa gagcaaagta aatgtaagcc actgtgctgggtgctaacag
18601 ggaggataaa agtaaaagag aaacagcccc gatatctgtc taaccttccttcccagatga
18661 gtggaggaag gaggggctgg agggggatga gttttggact tgggccagggaggggatttc
18721 aggaatggag ggtgggaaag caaactggca gggaagacct ggaaagtctcagttgggtga
18781 ggagtggggg atgctggccc caggccaggg catggaacca gggcatgactatctgaaccg
18841 gtaagggcca caggagcagg tggggaactg gaagagcaac aacaaaggataaggaggaag
18901 aggtttggga gacaaaacct aggaaaagag gacctggtat gctaagggctgagtcctaac
18961 agcttcctaa caggaccccc aagccatctt ctactgctac ccaccaagctcatggtgtga
19021 taggagaaat ggagggagtc aggaaaattg tgtttataat acaatagacttcttgagaga
19081 tataatttga tttttttaaa aggaacaaat ttatactgag tgcctaccatgtccaggtgc
19141 tgtggaaggt gctggagact ctaaagtgga aagaaagaaa aaagagacaatttttttgcc
19201 ttcatgatgc ttacaagaaa atggggagag agggaggagg ggtgttctgtgcacaaagat
19261 cagtttgtat ctgtttgatt catgaccgga gtgaagggac cagtttctagttggagtgag
19321 ctgagttccc atccaccctt tcaaagcccc caccatctct ctgctgctttgttccctggt
19381 tgcaattttc ttggtgccct cagcctagca cagatctttt ggaggttgacctgggtccct
19441 gaagatgagc ggagttatga ggctgcccgt ggggaaagaa tgggagaagaagcatgggtg
19501 aatcttgttc ctgaggttat agagggtgtt tcaagaggtg ccatggaaataagggtgcat
19561 agtgttcact gctgcgaaaa aggcaaaata cttttccact ctgtcggagtaaaatcgcaa
19621 aaatgctctt ctagggtggg acaggtgggt ctttattctg atgctaatggtgacatctgg
19681 tcagtcaagg ctcttggaag attcagctct gcataagctt ggggatggtgaagctaatgt
19741 cccaagaagc ccacaagaaa aagttagact tgtatgtcta tggatatggtcaggggtttc
19801 tgaggcaaat caatgtagat aaggaagtct gtgagttggc atatgcttgaggaaaacatg
19861 gtatcaggag gcaggtatta tactggttta ggtcagggct ttggtttcagatagaccttg
19921 gtttgattcc agctctgcat tttaccacct atgtgagttt gggcaagttactggaactct
19981 ctaaagcttg agtttcctta tctgtcctaa tagtgtagat cataacagtactttcttgta
20041 gggttgttgt aaggatgaaa taactcacat tgcaagtgct caataaatgttcttattagc
20101 gaaatgatgg ttatctagtg attcatctag agcacagccc tcaaacttgaatgggtccag
20161 agacctgcta ctcaaagtgt gggcaccagc ccagtaggac tgacatcaactggaatctga
20221 tgggaaatgc agaatctcag gctctaggcc agaactactc aatcagaacttgccttttaa
20281 caagatccta gatgattcac acgcacattc cagtctgaga agctctgatccggaagagat
20341 caggagatgt tcaagtgctg aaacacaagt aaggcatggc agaagctaaaatgtgaagta
20401 ttgagagtaa accaggagag cagatggtta ttccttccat cccttaaggatcttatcttt
20461 caaacttctg ctttaccact tcaacacaca aaacagagat agatttccttctaggagtgt
20521 gtgtgtgtgt gtgtgtgtgt gtgtgtgttg agaacatcaa tggttcaataattgcttcat
20581 agtcttttct tccaggaaag agcatttgaa tttggctaca gagaatagataggtgggatt
20641 ttattaggca gagcaaggtg gaaaggacat atttgggaga cagaagacataagcaaaggc
20701 aagaggcagg agaattcagg gcactttctt ggactcctaa gtagttaagtttgactggag
20761 tagggagtgg gtagtagagt gatgagaata gttgtaagta agactggaaatacatgtgaa
20821 acctgggtca tgaagggcct tgactcctct tcaagatttt ggattttattctgaactact
20881 gaaggcattt attgtacatg tctgtgcatt cttcttgcac aaacagtccagctcccaagg
20941 aagaggggcc cagcccattg gaggtggccc cacgtccttc agtgcctggagttcttgtcc
21001 ttcagagtgg gctgggggtg gagctggaca tcctgaaaac ttttagtgagattgcaatca
21061 gatgagctca tttacaaatg gccctacgct gttgacttgg tcattttatggacagtgcta
21121 atggcccagt cagttaggcc tacgtttggt tcacctgtgt atacatcacttggatattat
21181 gtcccatatc attgttggcc cttctgagtt aagttcgttg gcacagatttactttgtcca
21241 cccagactga aactgcacct ctgaagactc catcacggaa ggtgactctgtgaataactg
21301 cttagtcaac ctaatagatg atctagatga gagattagca aatttaacactactccaagg
21361 tgaggtatca agcagctctt cccacataca gggagatggg gggagaacagactaaggaag
21421 atcttggact ctctctctca ttagagaaat gggggtggga attagggactagcctgtgta
21481 ctactgacct atggcatagt ctctcaaaac ccatttcaga gccaggcacagtggtacatg
21541 cctgtagtcc tggctacaca ggaggctgag gcaggaggat cccttgagctcaggagttta
21601 aggctgtagt gtgctatgat catgcctgtg aataaccact gcactgcagcctggacaaca
21661 tagcaagact ctgtctctaa aaacaaaaca aaacaaacaa acaatcatttctgatagttt
21721 actttgcctg tcaaaatgaa gagcaggtag gatagaatca aaagctttaaaaaaatcaaa
21781 acagcttaca gctgctattt tctctctgcc tctgcgatca ttcagagaaaataaattcac
21841 tggtctagtc caacttattc ttccctaagc cctgctgttt tttttttctagtatttcata
21901 ttgccttggt ggttgctaag tgattgttgg atttagcccc agtatattctcagataacta
21961 tgccaataat ctataattac cagaattcat cttttctccc ttttggaaagatggactggc
22021 tatttttttc ttgtaaacct tgggtgttta attctgccct acaggatgatgtcagagata
22081 atagctggtg agtctttaat aataactgcg aattcctaca atattgtaaggtaaacgtca
22141 aaaggtttca tgcatatata tgtatctttt aatctttcat ttgaacagtttcacttttta
22201 tgatcttgct gttggttctg gaattatagg acaaattttt cttttcttttcttttctttt
22261 tgagacaggg ccttgctctg tcactcatgc tggagtacag tggcttgatcatagcttcct
22321 gcagcctcta attcctgggt tcaagtgatc ctcctgcctc agctgccaaagtagctggga
22381 ctacaggtgc acatcaccac gcctggttaa ctttttattt ttttttttagagacacggtc
22441 atgctatgtt gcccaggctg gtctcaaact cctggggtca agtgatcctcctgcctcaga
22501 ctccaaagtg ttgggattat aggcatgaga caatacacct ggcccaggggatttttttct
22561 ccatcactta acatgaaatt caccaagcaa aacctcttac ataaccatgggaccaataat
22621 ctcagattct ccattcccct ccccaccttg atattaggat tatgcagcttaatgagtcaa
22681 gctgtcccac cctacccacc tattactccc actcccagga taccaggagttttgtatggg
22741 atacataaat gatccttttt tccattccgt taagctgtat gcaaattgtgtgtgtgctta
22801 tgtacatttt tctggggata actttggtag ttttcatcag attcttaaaggtgtctgttt
22861 gctaaagcca gattaagagc tactataaag aacacatagc ctccgttattccagcccaat
22921 ctttggaaat agagattatc agaatgggta catcctaata tttgccgcaaatgactctga
22981 agatgcggat gcaattacat aaatcccagg ctccttcaac atataaacccagaagtgtga
23041 tttcagggcc ccagacatgc cctgtctcta cttcattctc ttgtcccaaattgcagcacc
23101 cagaatattt cttcctaagc attactcagg ctatcctatt ttcttattcagaaactatat
23161 tcctgttctt tagctatttc ctgcacaaat caatttcttt tttttttttttttttttggt
23221 agtcatttta atttacttct tggtttcaat ttggattgac tttctgcattttgctactgg
23281 tagaattgca atgcattggg ccagtggtag accactacct gtcaggagaaatttcttttg
23341 ttctttggtt tttactcgca catcacagtg atgggcgtca ttcagtggttctaaaccctc
23401 agtacactta gaaatcacct aagaagcttt gaaaaccatg aaagcctggtccctatctcc
23461 aaggatttta attcaatcga tctgaatgag gcctgggtgt tgacttaaaaaaaatgcaac
23521 atgcattgag ccactggtct aatctagcag gaattggcaa cgagtgtgagggtctttcaa
23581 aagatgctgt tttacctggc taaggttgtg gcatgcccac agagtaaccacctccttttc
23641 tttccccaga tggtgctcct ggccaggtgc gaggggcact gcagccaggcgtcacgctcc
23701 gagcctttgg tgtcgttcag cactgtcctc aagcaaccct tccgttcctcctgtcactgc
23761 tgccggcccc agacttccaa gctgaaggca ctgcggctgc gatgctcagggggcatgcga
23821 ctcactgcca cctaccggta catcctctcc tgtcactgcg aggaatgcaattcctgaggc
23881 ccgctgctgt gtgtggcttc tggatgggac aactgtagag gcagttcgaccagccaggga
23941 aagactggca agaaaagagt taaggcaaaa aaggatgcaa caattctcccgggactctgc
24001 atattctagt aataaagact ctacatgctt gttgacagag agagatactctgggaacttc
24061 tttgcagttc ccatctcctt tctctggtac aatttctttt ggttcattttcagattcagg
24121 cattttcccc cttggctctc aatgctgttt gggtttccaa caattcagcattagtgggaa
24181 aaagtgggcc ctcatacaca agcgtgtcag gctgtcagtg tttggtgcacgctggggaag
24241 aatttacttt ggaaagtaga aaagcccagc ttttcctggg acatcttctgttattgttga
24301 tgtttttttt taccttgtca ttttggtcta aggttgccat tgctgctaaaggttaccgat
24361 ttcaaagtcc agataccaag catgtggata tgtttagcta cgtttactcacagccagcga
24421 actgacatta aaataactaa caaacagatt cttttatgtg atgctggaactcttgacagc
24481 tataattatt attcagaaat gactttttga aagtaaaagc agcataaagaatttgtcaca
24541 ggaaggctgt ctcagataaa ttatggtaaa attttgtaag ggagcagacttttaaagact
24601 tgcacaaata cggatcctgc actgactctg gaaaaggcat atatgtactagtggcatgga
24661 gaatgcacca tactcatgca tgcaaattag acaaccaagt atgaatctatttgtgggtgt
24721 gctatagctt tagccgtgtc acgggcatca ttctctaata tccacttgtccatgtgaaac
24781 atgttgccaa aatggtggcc tggcttgtct tctgaacgtt tggttcaaatgtgttttggt
24841 cctggaggct caaattttga gttattccca cgttttgaaa taaaaagagtatattcaaaa
小鼠成熟NDP蛋白(SEQ ID NO:23)(NCBI登录号NP_035013.1)
KTDSSFLMDSQRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECSS
小鼠成熟NDP cDNA(SEQ ID NO:24)
aaaacagacagttcatttctgatggactctcaacgctgcatgagacaccattatgtcgattctatcagtcacccactgtacaaatgtagctcaaagatggtgctcctggccagatgtgaggggcactgcagccaggcatcacgctctgagcccttggtgtccttcagcactgtcctcaagcaacctttccgttcctcctgtcactgctgccgaccccagacttccaagctgaaggctctgcgtctgcgctgctcagggggcatgcgacttactgccacttaccggtacatcctctcctgtcactgtgaggaatgcagctcc
恒河猴成熟NDP蛋白(SEQ ID NO:25)(NCBI登录号NP_001253901.1)
MRKHVLAASFSMLSLLVIMGDTDSKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS
大鼠成熟NDP蛋白(SEQ ID NO:26)(NCBI登录号NP_001102284.1)
KTDSSFLMDSQRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECSS
黑猩猩NDP蛋白(SEQ ID NO:27)(NCBI登录号XP_016799622.1)
KTDSSFVMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS
Trio Rho鸟嘌呤核苷酸交换因子(TRIO)和F-肌动蛋白结合蛋白(TRIOBP)
TRIOBP基因编码“trio Rho鸟嘌呤核苷酸交换因子(TRIO)和F-肌动蛋白结合蛋白”(TRIOBP)(一种沿静纤毛肌动蛋白丝的长度并在内部毛细胞的静纤毛小根中表达的蛋白)。TRIOBP对于内耳中特化毛细胞的静纤毛的稳定性和刚度很重要(参见，例如，Kitajiri等人(2010)Cell 141:786-798；和Zhao等人(2015)Curr.Opin.Neurobiol.34:172-179)。
长度为约10-50μm的静纤毛对于听力和平衡是重要的。静纤毛在听力中起着机械感应作用。通过响应于声音而弯曲，它们形成了机械接收声音刺激的结构。
人TRIOBP基因位于染色体22q13.1上。其包含24个外显子，涵盖约80千碱基(kb)(Hirosawa等人(2001)DNA Res 8:1-9；NCBI登录号NG_012857.1)。迄今为止，存在三个已知的TRIOBP剪接异型体家族：TRIOBP-5、TRIOBP-4和TRIOBP-1(参见，例如，Kitajiri等人(2010)Cell 141:786-798)。TRIOBP-1被普遍表达，而TRIOBP-5和TRIOBP-4主要在内耳和眼中表达。最长的异型体TRIOBP-5基因(NCBI登录号NM_001039141)包含24个外显子，TRIOBP-5异型体的翻译起始位点是在外显子3中发现的。TRIOBP-5蛋白的分子量约为218kDa。TRIOBP-4是由外显子1-6编码的基因，并与TRIOBP-5由相同的启动子表达。TRIOBP-4蛋白的分子量约为107kDa。TRIOBP-1(NCB1登录号NM-007032)由外显子11a-24编码，分子量约为72kDa，并从外显子11a中的起始位点翻译而来(参见，例如，Siepel等人(2001)J.Cell.Sci.114:389-399)。
TRIOBP基因中的各种突变已与非综合征性听力损失相关联(例如，严重的语前聋DFNB28(MIM#609761)(参见，例如，Riazuddin等人(2006)Am J Hum Genet 78:137-143)和年龄相关听力损伤(参见，例如，Hoffmann等人(2016)PLoS Genet 12(10):e1006371))。导致DFNB28的突变主要发现于TRIOBP的外显子6(一种在TRIOBP-4mRNA和TRIOBP-5mRNA中都存在的外显子)中。DFNB28-耳聋可通过产生TRIOBP-4/5缺陷型小鼠来建模，其中将小鼠外显子8(人TRIOBP-4和TRIOBP-5的外显子6的直向同源物)突变/删除(参见，例如，Kitajiri等人(2010)Cell 141:786-798)。无义突变(TRIOBP-5的外显子9中的c.5014G>T(p.Gly1672*))和移码突变(外显子6中的c.2653del(p.Arg885Alafs*120)、c.3460_3461del(p.Leu1154Alafs*29)和c.3232dup(p.Arg1078Profs*6))是在患有先天性和中度听力损伤的荷兰家族中发现的(参见，例如，Wesdorp等人(2017)Hearing Research 347:56-62)。在外显子9中发现的无义突变是仅在TRIOBP-5中存在的第一个疾病相关突变。
已在患有听力损失的受试者中检测到的TRIOBP基因中的其它示例性突变和编码TRIOBP的核酸的测序方法描述于例如Shahin等人(2006)Am J Hum Genet 78:144-152；Diaz-Horta等人(2012)PLoS One 7:e50628；Gu等人(2005)Clin.Genet.87:588-593以及Wesdorp等人(2017)Hearing Research 347:56-62中的表1中。检测基因中的突变的方法是本领域公知的。此类技术的非限制性实例包括：实时聚合酶链式反应(RT-PCR)、PCR、测序、Southern印迹和Northern印迹。
示例性人野生型TRIOBP蛋白为或包括SEQ ID NO:28、SEQ ID NO:30或SEQ ID NO:31、SEQ ID NO:32的序列。编码野生型TRIOBP蛋白的核苷酸序列的非限制性实例为或包括SEQ ID NO:29和SEQ ID NO:33。
在本文所述的任何组合物的一些实施方案中，所述TRIOBP蛋白包含与SEQ ID NO:28具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，所述TRIOBP蛋白包含与SEQ ID NO:30具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，所述TRIOBP蛋白包含与SEQ ID NO:31具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，所述TRIOBP蛋白包含与SEQ ID NO:32具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
人全长野生型TRIOBP蛋白异型体5(SEQ ID NO:28)
MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPSGAEVPYCDLPRCPPAPEDPLSASTSGCQSVVDPGLRPGPKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLEGLTTSLCGSCNEDPGSDPTSSPDSATPDDTSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQDEGRSQQPSQGQSQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQPEAWEEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRGSERRPELDWRDLLGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALGPELGPPGTNDVPEQESHSQPEGWAEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIKVTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQPEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE
人野生型TRIOBP异型体5cDNA(SEQ ID NO:29)
atggaggag gtgcctgggg atgccctgtg tgaacacttt gaggccaaca tacttacccagaaccgctgt caaaactgct tccaccctga ggaggcccat ggagcaagat accaggagct caggagcccttcaggtgctg aggtgcccta ctgcgacctg cctcgatgtc cacctgcccc tgaggaccca ctcagcgcctcaacctccgg ctgccagtct gtggtggacc caggcctcag gccagggccc aagaggggcc catccccctcagcagggctc ccagaagagg gtcccacagc tgcccccagg agcaggagcc gggagcttga ggcagtaccctatctggagg gcctgaccac ttccttgtgt ggcagctgca acgaggaccc cggctctgac cccacctccagccctgactc cgccacccct gatgatacca gcaactcgtc ctctgtggac tgggacactg ttgagaggcaggaggaggag gcccccagct gggacgagct cgcagtgatg atcccgagga ggcctcggga ggggccgagagctgacagct cccaaagggc tccgtctctc ctcaccaggt cccctgtggg aggagatgct gcaggccagaaaaaggagga caccggcggt gggggccgga gcgcaggaca gcactgggca aggctccggg gagaaagcgggttgtccctg gagcggcacc ggtcaacact gacccaggct tcctccatga caccacacag tggacctcgaagcaccacgt ctcaggcttc tcctgcccaa agggacactg ctcaggctgc ctctacacgt gaaatccccagagcctcctc tccccatcga atcacccaaa gggacacctc cagggcctca tccacccaac aggaaatctccagggcctca tccacccaac aggaaacctc cagggcctca tccacccaag aggacacccc tagggcctcatccacccaag aggacacccc cagggcctca tctacacagt ggaacacccc cagagcttcc tctccctcacgaagcaccca actggataac cccagaacct cttctaccca gcaggacaac ccccaaactt cttttcctacttgtactccc cagcgggaaa accccaggac accctgtgtc cagcaggacg atcccagagc ctcctctcccaacagaacca ctcaacgaga gaattccaga acatcctgtg cccagcggga caatcccaaa gcctccagaacctcctctcc caatagagcc acacgagaca accccagaac atcctgcgcc cagcgggaca atcccagagcctcctctccc agtagagcta cacgagacaa ccccacaaca tcctgtgccc agcgggacaa tcccagagcctccagaacct cctctcccaa tagagccaca cgagacaacc ccagaacatc ctgtgcccag cgggacaatcccagagcctc ctctcccagt agagctacac gagacaaccc cacaacatcc tgtgcccagc gggacaatcccagagcctcc agaacctcct ctcccaatag agccacacga gacaacccca gaacatcctg cgcccagcgggacaatccca gagcctcctc tcccaataga gctgcacgag acaaccccac aacatcctgt gcccagcgggacaatcccag agcctccaga acctcctctc ccaatagagc cacacgagac aaccccagaa catcctgtgcccagcgggac aatcccagag cctcctctcc caatagagct acacgagaca accccacaac atcctgtgcccagcgggaca atcccagagc ctccagaacc tcctctccca atagagccac acgagataac cccagaacatcctgtgccca gcgggacaat cccagagcct cctctcccaa cagaaccacc caacaagaca gccccagaacatcctgtgcc cgacgggacg atcccagagc ctcctctcct aacagaacca tccaacaaga gaaccccagaacatcctgtg ccctacggga caatcccaga gcctcctctc ccagcagaac catccaacaa gagaaccccagaacatcctg tgcccaacgg gacgatccca gagcctcctc tcctaacaga accacccaac aagagaaccccagaacatcc tgtgcccgac gggacaatcc cagagcctcc tctcgcaaca gaaccatcca gcgagacaaccccagaacat cctgtgccca gcgggacaat cccagagcct cctctcctaa cagaaccatc caacaagagaacctcagaac atcctgtacc cgacaggaca atcccaggac ctcctctccc aatagagcca cacgagacaaccccagaaca tcctgtgccc agcgggacaa tctcagagcc tcctctccca tcagagccac ccaacaggacaaccccagaa cttgtattca acagaacatc cccagatcat cttctaccca acaagacaac cctaaaacctcttgtaccaa acgagataac ctcagaccca cttgtacaca gcgggaccgc acacagtcct tttcctttcaacgagacaac cctggaacct cctcatctca atgctgcacc caaaaggaga atctgagacc atcatctccccaccgctcca ctcaatggaa caatcccagg aattcatctc cccatcgtac taacaaagac atcccctgggcctcgtttcc cctccggcca actcagagtg atggtccccg aacctcttcc ccatctcgct ccaagcaaagcgaggttccc tgggcatcca tcgccctccg gccaacccaa ggtgacaggc ctcagacatc ctctcccagcaggccagccc agcatgaccc accccagtcc tcctttggcc ccacccagta caacttgcca tcccgggccacctcttcctc ccataaccca ggccaccaga gcacctcccg aacttcctca cctgtgtacc ccgctgcctatggggctccc ctgacctctc ctgagccctc ccagcctcca tgtgctgtgt gcattgggca ccgggatgcccctcgagcct cttcgccccc tcgctatttg cagcacgacc ccttcccctt cttcccagag ccccgcgcccctgagagtga accgccccac cacgagcctc cctatatacc acctgctgtg tgcattggac accgagatgccccccgggcg tcctcgcccc cccgccacac ccaatttgac cccttcccct tcctcccaga cacatcagatgccgagcatc agtgtcagtc cccccaacac gagccccttc agctccctgc acctgtgtgt attgggtaccgagatgcacc ccgggcctcc tccccaccac gccaggcccc agagccttcc ctcttattcc aggacctccccagggccagc acagagagcc ttgtcccttc catggactct ctgcacgagt gcccccacat ccccacccctgtgtgcattg ggcaccggga tgcaccctcc ttctcatccc caccacgcca ggctcctgag ccatccctcttcttccagga tccccctgga actagtatgg agagcctggc cccctccact gactctctgc atggctccccagtgctgatc ccccaagtgt gcatcgggca ccgggatgca ccccgagcct cctccccacc ccgccacccacccagtgacc tagcgttcct ggcaccctca ccttcaccgg gcagctctgg gggctcccgg ggctcagcgcctcccgggga gaccaggcac aacttggagc gggaggagta cactgtgctg gccgacctgc ccccacccaggaggctggcc cagagacagc cagggcccca ggcgcagtgc agcagcgggg gccgcaccca cagccctggccgtgcagagg tggagcgcct cttcgggcaa gagcgcagga agtccgaggc agcgggggcc ttccaggcccaggacgaggg acggtcacag cagcccagcc aaggccagag ccaacttctc cgaagacagt ccagccctgcccccagcagg caggtgacca tgctccctgc caaacaggca gaactgaccc ggcggagcca agcagagccccctcatcctt ggagtcctga gaagagacct gagggagatc ggcagctcca ggggtccccg ctgccccccaggacatcagc caggacccct gagagggagc tgcggacaca gagacctctg gagagtggcc aagcaggcccaagacagcct ctgggggtgt ggcagagtca ggaggaaccg ccagggtccc agggccctca tagacacctagaaaggagct ggagcagcca ggagggaggc ctgggccctg ggggctggtg gggatgtgga gagcccagcctgggggcagc caaagccccg gagggagcat gggggggcac ttccagggag tacaaggaga gctgggggcagccagaggcc tgggaggaga agcccactca tgagctcccc agagaactag gaaagagaag cccactcacgagcccccctg agaactgggg aggccccgca gagtcctcac aatcctggca ctctgggaca cccactgctgtgggctgggg ggcagaggga gcgtgtccat acccgcgtgg ctctgagagg cgacccgagc ttgactggagggatctgctt ggccttctcc gggcaccagg agagggggtc tgggcccgtg tccccagcct ggactgggagggcctcttgg agctcctgca ggccaggctg ccccgcaagg acccagctgg acacagggat gacctggccagggctttagg gccagagctg ggtcccccag gcacaaacga tgtccctgag caggagtcac acagccagccagaaggctgg gccgaggcca ccccagtcaa tggacacagc cccgcactgc agtcccagag cccggtccagctgcccagcc ctgcctgcac ctccacccag tggccaaaga tcaaagtgac aagaggacca gcgaccgcaactctggcagg cctggagcag acgggccccc tggggagcag gagcactgcg aagggcccca gcttgccagagctgcagttc caaccagagg agcctgagga gtcagaacca agcagaggcc aagaccccct gactgaccagaagcaggcag actcggcaga caagaggcca gcagagggca aggctgggag cccgctcaag ggccgactggtgacctcatg gcggatgccc ggggaccggc ccacgctgtt caatccgttc ctgctgtctc tgggggtcctcaggtggcga aggcccgatc tgctcaactt caagaaggga tggatgtcga tcttggacga gcctggagagcctccctccc cctcgctcac caccacctct acttcgcagt ggaagaaaca ttggtttgtg ctgacagattcaagtctcaa atattacaga gactccactg ctgaggaggc agatgagctg gatggtgaga tcgacctgcgttcctgcacg gatgtcactg agtacgcggt gcagcgcaac tatggcttcc agatccacac caaggatgctgtctatacct tgtcggccat gacctcaggc atccggcgga actggatcga ggctctgaga aagaccgtacgtccaacttc agccccagat gtcaccaagc tctcggactc taacaaggag aacgcgctgc acagctacagcacccagaag ggccccctga aggcagggga gcagcgggcg ggctctgagg tcatcagccg gggtggccctcggaaggcgg acgggcagcg tcaggccttg gactacgtgg agctctcgcc gctgacccag gcttccccgcagcgggcccg caccccagcc cgcactcctg accgcctggc caagcaggag gagctggagc gggacctggcccagcgctcc gaggagcggc gcaagtggtt tgaggccaca gacagcagga ccccagaggt gcctgctggtgaggggccgc gccggggcct gggtgccccc ctgactgagg accagcaaaa ccggcttagt gaggagatcgagaagaagtg gcaggagctg gagaagctgc ccctgcggga gaataagcgg gtgcccctca ctgccctgctcaaccaaagc cgcggagagc gccgagggcc cccaagtgac ggccacgagg cactggagaa ggaggttcaggctcttcggg cccagctgga ggcgtggcgt ctccaagggg aggctcctca gagtgcactg agatcccaggaggatggcca catccccccg ggctacatct cacaggaggc atgtgagcgc agcctggcag agatggagtcctcgcaccag caggtgatgg aggagctgca gcggcaccac gagcgggagc tgcagcgcct gcagcaggagaaggagtggc tcctggctga ggagacggca gccacggcct cagccattga agccatgaag aaggcctaccaggaagagct gagccgagag ctgagcaaaa cacggagtct ccagcagggc ccggatggcc tccggaagcagcaccagtca gatgtggagg cactgaagcg agagctgcag gtgctatcgg agcagtactc gcagaagtgcctggagattg gggcactcat gcggcaggct gaggagcgcg agcacacgct gcgccgctgc cagcaggagggccaggagct gctgcgccac aaccaggagc tgcatggccg cctgtcagag gagatagacc agctgcgcggcttcattgcc tcgcagggca tgggcaatgg ctgcgggcgc agcaacgagc ggagttcctg cgagctagaggtgctgcttc gcgtaaaaga aaacgaactc cagtacctaa agaaggaggt gcagtgcctc cgggacgagctccagatgat gcagaaggac aagcgcttca cctcgggaaa gtaccaggac gtctatgtgg agctgagccacatcaagaca cggtctgagc gggagatcga gcagctgaag gagcacctgc gtcttgccat ggccgccctccaggagaagg agtcgatgcg caacagcctg gctgagtag
人全长野生型TRIOBP蛋白异型体1(SEQ ID NO:30)
MTPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE
人全长野生型TRIOBP蛋白异型体4(SEQ ID NO:31)
MIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERR
人全长野生型TRIOBP蛋白异型体6(SEQ ID NO:32)
MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPSGAEVPYCDLPRCPPAPEDPLSASTSGCQSVVDPGLRPGPKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLEGLTTSLCGSCNEDPGSDPTSSPDSATPDDTSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQDEGRSQQPSQGQSQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQPEAWEEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRGSERRPELDWRDLLGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALGPELGPPGTNDVPEQESHSQPEGWAEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIKVTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQPEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE
人野生型TRIOBP基因DNA序列的非限制性实例是SEQ ID NO:33。SEQ ID NO:33中的外显子是：核苷酸位置1-102(外显子1)、核苷酸位置601-709(外显子2)、核苷酸位置4319-4492(外显子3)、核苷酸位置13440-13579(外显子4)、核苷酸位置16223-16424(外显子5)、核苷酸位置18776-18947(外显子6)、核苷酸位置26198-29516(外显子7)、核苷酸位置36311-36425(外显子8)、核苷酸位置37412-38455(外显子9)、核苷酸位置41655-41732(外显子10)、核苷酸位置43908-44045(外显子11)、核苷酸位置54785-54841(外显子12)、核苷酸位置57890-57997(外显子13)、核苷酸位置58114-58203(外显子14)、核苷酸位置58563-58672(外显子15)、核苷酸位置60626-61151(外显子16)、核苷酸位置62167-62277(外显子17)、核苷酸位置68683-68830(外显子18)、核苷酸位置71087-71189(外显子19)、核苷酸位置72041-72200(外显子20)、核苷酸位置72275-72388(外显子21)、核苷酸位置74663-74749(外显子22)、核苷酸位置75614-75777(外显子23)和核苷酸位置76796-79569(外显子24)。内含子位于SEQ ID NO:33中的这些外显子的每一对之间，即处于核苷酸位置103-600(内含子1)、核苷酸位置710-4318(内含子2)、核苷酸位置4493-13439(内含子3)、核苷酸位置13580-16222(内含子4)、核苷酸位置16425-18775(内含子5)、核苷酸位置18948-26197(内含子6)、核苷酸位置29517-36310(内含子7)、核苷酸位置36426-37411(内含子8)、核苷酸位置38456-41654(内含子9)、核苷酸位置41733-43907(内含子10)、核苷酸位置44046-54784(内含子11)、核苷酸位置54842-57889(内含子12)、核苷酸位置57998-58113(内含子13)、核苷酸位置58204-58562(内含子14)、核苷酸位置58673-60625(内含子15)、核苷酸位置61152-62166(内含子16)、核苷酸位置62278-6862(内含子17)、核苷酸位置68831-71086(内含子18)、核苷酸位置71190-72040(内含子19)、核苷酸位置72201-72274(内含子20)、核苷酸位置72389-74662(内含子21)、核苷酸位置74750-75613(内含子22)和核苷酸位置75778-76795(内含子23)。
人野生型TRIOBP基因组序列(SEQ ID NO:33)(NCBI登录号NG_012857.1)
1 cttccacctc ccgagcatcg ctctgattca ttgttaaaat aaagaggcca tgaccctggc
61 actcccaccc cggcagcccc tgtgcgtgga aacccagcca aggttagcac tgggcctcag
121 aaaagaggag ctggtagggg gaggcctaca ggaggggtag gggtcgaggg atccggggag
181 gaactggctg aatgcctgga tggagagggt cccgggtcca ttctctgggt ggggcatgtg
241 tagctgctta aggttttgat tattatatcc acatctcaag tgcattttag agaaggattc
301 tgcctattgg ttgtgggtag gggaggaaac gggagcagcg aggggcacgt ggagtagagc
361 cccctaccca cccccaggaa aatgagcggc gttctcctgc taggcgacgc tcctttatgt
421 ggccagacca ggagagaaac gcccaggacg ggcggggccg atgcgcccct cttccaccac
481 caggagtcgg gaggacgacc gcccggggag gatcagagac cctggggcca cggaaggacc
541 agtgggtagc cctctcccca ccgtgccttg ctgtcgcccc caccgcattc ccttctccag
601 gtctgatgat ggaggagcct tggccctggc tgtcccaggg gaggaggtga aattcctcag
661 ctctccacca agattggcca caaaagcctg atcccctgga acacagcagg tgaggatgga
721 tgtgggcagg tgacctgggg gcaccaaaag ctgcaggtgt tttgggatgt tgggttcctc
781 ccacccccca ccctccccct ggggctctgt gtgagtgggg aggccatctt taagtgattc
841 tcctgaccca gctccactcc agggcatgga tgttggtggc cttaggggca cccagaaagg
901 agaacccttg cacaagtaag ataccagggc ggccgggcgc ggtggctcaa gcctgtaatc
961 ccagcacttt gggaggtcga ggtgggtgga tcacaaggtc aggagttcga gaccagcctg
1021 gcccatatgg tgaaacctcg tctctaccaa aaatacaaaa aaattatccgggcatggtgg
1081 cacatgcctg taatcccagc tatttgggag gctgcggcag gagaattgcttgaatccggg
1141 aggcagaggt tgcagtgagc cgagatcgcg ccactgcact ccagcctgggtgatagaccg
1201 agattctgtc tcaaaaaaaa aaaaaaaaaa agaaagaaag acaccagggtttcagaaggg
1261 tatgatgctt cacacctgta atcccagcac tttgagggaa ggaggaggattacttgaggt
1321 caggagttca ggagttcaaa accagcctgg gtaacactgc aagagccttttttttttttt
1381 tttttttttt tgagacacac tgttgcccag gctggagtgc agcggggcgatcttagctcc
1441 actgcaacct ccacctcctg ggttcaagca attctcttgc cccagcctcttgagtagctg
1501 ggattacagg catgcgcacc acgcccagct aatttttata gttttagtagagacagggtt
1561 tcatcatgtt gggcaggctg gtcttgaatt cctggcctca agtgatctgcctgcctcagc
1621 ctcccaaagt gctgggatta taggcgtgag ccaccgcacc tggccaagagcccattttta
1681 caaaataaaa aagaaaaaaa ttagctgggc gtggtggcgt acacctgtagtcccagttac
1741 tcagtcccag agactgaggc aggagaatca tttgagcccg ggagtttgaggttgcaagga
1801 gctatgatcg agccactgca ctccagcctg ggtgacagag caagaccctgcccccacctc
1861 cccaaaaaag acattagggg ccggatgcag tggctcacac ctgtaatcccagcattttgg
1921 gaggccgaag ggggcggatc acctgaggtc aggagttcac ctggccaacatggcgaaacc
1981 ccgttgctac taaaaataca aaaattagcc aggcatgacg gtgcatgcctgtgatcccag
2041 atactactgg ggaggctgag gtagaattgc ttgaacccag gaggcggaggttgcagtgag
2101 ccgagtgagc caagatcaca tcacggcact ccagcctagg tgacagagagagacttcgtc
2161 tcaaaaaaac aaaacaaaac aaaacgaaaa cacattagga tttctttttggctaagttct
2221 gccacaaact tgctgtgtga ctttaggctg ttcacgtttg tcaaagacgtcgtcctcaac
2281 tctgaaaata cctggccagc tttttgcctc cctcgctgtg cttcccaagggacctgtgcg
2341 agttggcagt atgatccagt gctcctcact tccacctccg agagagcagggacacacaca
2401 gccctggatt tgaatcagcc actgcgacct tcagtgaccg aaggaacctctctgagcctt
2461 agttgcctga tctaaaattg gcattaattt gatctacaat gcagctataagacaaggaca
2521 ctcaaacttt ggggcgcact agaatcacct ggggaatcac tttttttttttaagacagag
2581 tctcactctt atcacccagg ctggagtaca gtggtgcaat cttggctcactgcaacctcc
2641 gcctcctggg ttcaagtgat tctcctgcct cagcctcccg agtaactgggactacaggtg
2701 cataccacca tgcctggcta attttgtatt tttagtagag acagggtttggcaatattgg
2761 ccaggctggt ctcgaactcc tgacctcagg tgatctgccc gcctcggcctcccaaagtgc
2821 tgggattata ggcgtgagcc actgcgcctg gccaggaatc gcttctttattttcattttc
2881 atttatttat ttatttattt atttattttg agatggagtc tcgctctgttgctcagtctg
2941 gagtgaagtg gcgtgctctc cgctcactgc tacctctgcc tcccaggttcaagcgattct
3001 cgtgcctcag cctcccaagt agctgggact acaggtgcgt gctaccacgcccagctaatt
3061 tttgtattta gtagaggcgg ggtttcacca tgttggccag gctggtcttgaactcctggc
3121 ctcaagtgat ctgcctgcct cagcctccca aagtgctggg attacaggcgtgagccaccg
3181 ccctcggctg gaatcacttc tttaacatgc acagccccag acctcagtctcttggagatt
3241 ctaactgtgt gaattgggag agagaaaggg gaatctagat tttttttttttttttttgag
3301 atgtggtctt gctatgttgc ctaggctgga gtgctgtaac tattcacaggtgcagttata
3361 gcacactacc acctcaaact cctgggctca agagatcctc ccacctctgcctcccgagta
3421 gcttggactg caggtgcaca ccatcttacc cagctgaaat ctgctttttttttttctcag
3481 tgcagtggca cagtcatggc tcactgcagc ctcgacctcc cagactcaggtgatcctccc
3541 aacttcagcc tcctgagtag cagggaccac aggcctgcac caccttgcccagctaatttt
3601 tgtatttttt gtagagacgg agtttcgcca gttgcccagg atggtcttgaactcttgggc
3661 tcaaatgatc cgccgcccgc aatgggccca gctggaatct gcatttttttgttttttgtt
3721 ttgagatgaa gtctcactct gtcgcccagg ctggagtgca atggcgcaatcttggctcac
3781 tgcaacctcc gcctcctggg ttcaagccat tctcctgcct caggctcccaagtagctggg
3841 attacaggca cgtgccatca cacttggctg atttttgtat ttttagtagagacagggttt
3901 taccatattg gccaggctgg tctcgaactc ctgacctcaa gtgatcggcccacctcggcc
3961 tcccaaagtg ctgggattac aggcatcagc cactgtgcct ggcctggtatctgcattttt
4021 atgaacagcc caggagggtg taatgcagag tccttggcgt gcactttcagcaacactgca
4081 gtaaggacta gaaatcgcac atcaaatgct ggcagagtgc ctggtgcttagtaggtgctt
4141 agtgagtgtt tgttgagtga ataaatgaac aggaatggat ggagaacaggaacccaaagg
4201 aatggatgag taaccttatt tccttggtcc ttgtctggaa actggggcaactggggctgg
4261 ggttcaggtg agtggccagc cagtcatctg gtctttgcct ccccctcatttttgccaggc
4321 ctcacataga cggtcagcca ttggatcata ggaactgccc tggcctgactcacccaatat
4381 ggaggaggtg cctggggatg ccctgtgtga acactttgag gccaacatacttacccagaa
4441 ccgctgtcaa aactgcttcc accctgagga ggcccatgga gcaagataccaggtgggcca
4501 gttttccacg tggttggggt ggtttgtgat gggggcatgg gtgaaggactgggcctgtgg
4561 tgtccgctaa ctcgcagttg aacccagatg ctggacttcc tcctgtcgagagcctcggtt
4621 ttcccacatt gcagggaagt ggttgaacca tgtgaatgtt tcacaatcttcagtcacttt
4681 cctcctgctt atatgatacg attgttacca tagccttatc taatctgttacttactttgt
4741 tattctttaa atcaacatct ttttcccctt ctattgaaac aaaacttcacatcatcaaca
4801 caagtagaaa actagaatta cttcctgtta agaagaagag gttaagaagaaaggtagagg
4861 ctgggcacgg tggctcacgc ctgtaatccc agcactttgg gaggccgaggtgggtggatc
4921 acccgaggtc gggagtttga aaccagcctg gccaacatgg tgaaaattagctgggcatgg
4981 tggtgcatgc ctgtaatccc agctacttgg gaggctgagg caggagaatcacttgaacct
5041 gggaggcgga gattgtggtg agccgagatc gcgccattgc actccagcctgggcaacaga
5101 atgaaactgt ctcaaaaaac aaaacaaaac aaaacaaaaa agagaagaaaggtagaaaaa
5161 gaaaaaacaa aacagaaatg tcgttacacc ctaacttgag agtgttttctttttcttttt
5221 cttttttttg agacagagtc tcactctgtc gcctgggcta gagtgcaatggcaatggtgt
5281 gatctcagct cactgcaatc tctgcctcct aggttcaagc gatcctcccgcctcagcctc
5341 ccaagtattg ggattacagg tgcctgccac catgcccagc taatttttgtatttttagta
5401 gaaacggggt ttcgccatat tggccaggct ggtcttaaac tcctgacctcaggtgatcca
5461 cccgcctcag cctcccaaag tgttgggatt acaggcgtga gccaccgcgcctggcctcga
5521 gagtgttttc tatggaaggc tctgagcttg catcctgctg tctctttgtcaaaaagggag
5581 attagcagat gttagagaga tgttaagaat acaccagcat catctagagattttctttct
5641 ctctctcttt tttttttttt tttttttttt tggagatagg gtcttgctctgtagcacagg
5701 ctggagtgca gtggtccaac ctatagtaca tggctcactg tagcctcgacctcccaggct
5761 caaatgatct tcccaccttg gcctcctgag tagcagggac tacaggcacatgccaccatg
5821 gccagctaat tttcttgtaa agatgggatc tcactatgtt gccagggctggtctcaaatt
5881 cctgggctca ggtgatcctc ccacctcaac ctctgtaact gcagggattacaggtgtgag
5941 acactgcacc tggtctcaag attttcttct tcaagttatt gaaggagtgaagaagaatcc
6001 ttttttttct ttcttttttt ttcatttgag acggagtctc tctctgtcgccaggctagag
6061 ttcagtggct caatctcagc tcactgcaac ctccgtctcc tgggttcaagcaattctcct
6121 gcctcagcct cctgagtacc tgggattaca ggtgcccacc accatgcccagctaattttt
6181 gtatctttag tagagacagg gtttcaccat gttggtcagt ctggtctcgaactcctgacc
6241 ttgtgatctg tctgcctcgg cttcccaaag tgctgggatt acaggtgtgagccaccgcgc
6301 ctggccgaga ttttcttctt caagttattg aaggagtgaa gaagagtccttttctgactt
6361 tgtgattgat gtagtctgct gccaagcccc catgcatgta aacacagagcacctgataca
6421 cacgcaatga gaaacctggg actcacgaac ctccgagggc ccttccaaccttgaccacca
6481 tggcttcgtc attcccattg gggtctgaag gtcctctttt tttttttttttttttgagac
6541 agagtctcgt tctgttgccc aggctggagt acagtggtgc gatctgggctcactgcaagc
6601 tcggcctccc aggtttatgc cattctcctg cctcagcctc atgagtagctgggacaacag
6661 gcacccggca ccacgcccag ctaatttttt gtctttttag tagagacagggtttcaccat
6721 gttagccagg atggcctcga tcttcctgac ctcgttattc gcccacctcgacctcccaaa
6781 gtgctgggat tacaggcatg agccaccgcg cccagcttct accagtcttgatacctccaa
6841 taatagctct cttgtgctca cctgcaagtt caggttcagg gaacagatgcctgggagtcc
6901 atctttcatg caaatgactt tcttccagtg gttgggaaga tggcaagaatggaacaggag
6961 agccgtggat tcaggctcgt ctgagttcta gtctcaatcc caccatttcccacccgagac
7021 cgtgggtcag ctcacaaatt catacgtact gaataggtgc ttaaaatgtgccaggcatta
7081 tgctagatga tggggaaatc atgataaatc agaaaggcac agccaggcacagtgactcac
7141 tcctgtaatc ccagcacttt gggaggccaa ggtgggtgga tcacttggagtttgagacca
7201 tcctggcaac atggcaaaac cccatctcta caaaaaattt aaaaaattagctgggcgtag
7261 tgggatgcgg ctatagtctc agttactcag gaggctgagg tgggagaatcacctgagact
7321 gggaggcggg ggcttcagtg agccgtgatc gcattactgt atttcagcctgggtgacaga
7381 gttggaccct gactcagaac agaacagaac agaacagaac agaacagaacagaacagaac
7441 agaacagaac agtacagaaa acagggagaa ggaggggaag ggggaggggaagggggaggg
7501 ggagagagag gaggagagga ggagagaggg acacatccct ggcttgtcttcatggggctt
7561 atattctagc aagagaaatg cacatgatta tttaatcttg gttgtgataaatgtataaag
7621 gaacagtaag tggcatgaag gtaaaggata gggcattagg gaaagtttctccaaaaaaaa
7681 aaaaatgaca tttcagctgc ttagtaaagg ctgtgcaggc attagcattagtgaaattgc
7741 aggaagagga gaggaaggaa ggagaatgtg caaaggccag cctggcacggcagctcacgc
7801 ctgtaatccc agcactttgg gaggaagtgc ttggattgag gcaccgaagcaggaagatca
7861 cttgaactca ggagtttgag accagcctgg gcagcacagt gagaccccatttctaccaaa
7921 aaaaaaaaaa aaaaaattag ccaggcagga tggtgcacac ctgtagtcccagctagtcag
7981 aaggctgatg tgggaggatt actggatccc aggagttcaa ggttgcagtgagccatgagc
8041 atgccaatgc actccagcct gggcaacaga atgagacctt gtctcaaaaacaaaacaaac
8101 aaacaggtca ggtgcagtgg ttcatgcctg taatctcagc actttacgaggccgagacgg
8161 gtggatcacc tgaggtcagg agttcaagac caccctggcc aacatggtgaaaccccatct
8221 ctattaaaaa tacacaaatt agctacatgt ggtggtgggt gcctgtaatcccaggtactt
8281 aggaggctga ggcaggagaa tctcttgaac ccaggaggca gaggttgcagtgagccaaga
8341 ttgcaccact gtactccagc ctgggcaaca gagcgagaat cctctcaaaacaaaacaaac
8401 aaacaaagaa tatgcaaagg ccctgaggca gaaaggaggc tgcacatcgggctggagagg
8461 acaggcaaga ggggggcaca gaggagctat aggacaagga tggagaatggggggaggcct
8521 ggtctcactg gccttgtgcg gctttgtgga catgttgagg acttaggattctgaggtttt
8581 tttctgtttt gtttttgttt ttttttgaga tggagtctcg ctctgtcgcacaggctggag
8641 tgcagaggcg tgatctcggc tcactgcaac ctctgcctcc caggttcaagcgattctcct
8701 gcctcagcct cccaggtagc tgagactaca ggcatgtact accaaacccagttaattttt
8761 gtatttttag tagagatggg gtttcaccat gccgctcagg ctggtcttgaactcctggcc
8821 tcaagcaatc tgccctcctt ggcctcccaa agtgctgaga ttacaagtgtgagccacctc
8881 gcccggccaa gccacggaag atttcaaata agggagtgac gtgctctgatttgcattttt
8941 cacagtcact ctgattgctg ggcagagaga atggagggca gggtggtgagagtgaatcag
9001 gtgacccgcc aggaaaaggt gcacgtactc atcggtgcca gagatgattggggctttgag
9061 atggaggcaa atggacacat ttccgaacta attgagcagg cacgtctacaggatttgggg
9121 gtgagggagg ggagaaaccc atggctgact cctgtaattt cttcaggcagggtacttggg
9181 ttgggaggtc tgtttggagt tgtctggggc atggtgtggg gtgtcggcaggatacagtgg
9241 agatgagggg gaagttagtg aattggtggg gctggagctc agagccagaccatcacagga
9301 gatggaggcc tgcgagtctt caggatctgt cactgaccaa agtcttgctcacggatgagc
9361 ctatcatctg tggaagaaag tgtggaatga gatgagaaca ggcctgggtggaggccaggg
9421 aatcagcaga gacagccaag aaggccagag gctaggaggc aaaccccacagtgtgcccct
9481 cctccccagg agccaagacc agagatggtt tcaagagagg gggccaggcacaatggctcc
9541 cgcctgtgat cacagcactt taggaggctg aggctaaagg atggcttgaaaccaggagtt
9601 taagaccagc ctagttaaca aagtgagatc ccatctctac aaaacaaaaaatgaactggg
9661 tgtagtggtg catgcctgca gtcccagcta cttgggaggc tgaggcaggaggattgtttg
9721 agcccaggag attgaggctg cagtgcactg tgatcatgcc actgccacagcaagactatc
9781 ttaaaaaaaa aaaaaaaaga tcagagaggg gcacgacatc aaatcctccactttcttgag
9841 cttccagttg ctctgatgat gatcaaggct gtgaaactct cctttggcaaatgcatgagg
9901 ggtgactgtt gtgtctccga gccaggccct gggacccaac tctgggcaggtagcagctcc
9961 ctgtgtatac cagatgtgat agtaaaaaac tgacactggg ccgggcgcggtggctcacgc
10021 ctgtaatccc agcactttgg gaggccgagg cgggtggatc acttgaggtcaggagtttga
10081 gaccagcctg actagcatgg tgaaatcctg actctactaa aaatacaaaaatacaaaaat
10141 taacagggtg tggtggcgga tgcctgtaat cccagctact cgggaggctgaggcaggaga
10201 atttcttgaa tccgggaggc ggaggttgca gtgagccgag atctggccaccgcactccag
10261 cctgggcgac aagagcgaaa aactccatct caaaaaaaac aaaaaaacctcctgggcccc
10321 agaagatggc aactgcctct tccagcctct tccacctgcc tgcctgtgcactcctctgcc
10381 actctggacc tattccatgg tgccacgtgg tcaggcattg aaggaatgggtgggtttttt
10441 ttccatcacc ctcagatgct gctgctgggg ttggggcggg tcttccctggctgactctgt
10501 ctgcctcacc cactctctcc ccatctctct gtcaccacag gtctccagggaccaaattta
10561 gcccattttt cctccaagga ttctggaccc ttggccatat ttgcctctagctttaggtca
10621 acagatttct aacatggagt caaaaaatct gtatgtttaa aaaaaaaaaattggctggga
10681 gtggtggctc acgtctgtaa tcccagcact ttgggaggcc gaggcaggtggatcacctga
10741 ggtcaggagt tcgagaccac cctggccaac atggtgaaac cccgtctctactaaaaatac
10801 aaaaattagc tgggtatggt ggcggacccc tgtagtccca gctactcaggaggctgaggc
10861 aggacaattg cttgaacccg ggaggcagag gttgcagtga gctgagatcgcgccattgca
10921 ctccagcctg ggtgacagag tgagactctg tctcaaaaaa aagaaaaaaaaaaaaaaggc
10981 cgggcgtggt ggctcacggc tgtaatccca gcactttggg aggccgaggcgggcggatca
11041 cgagatcagg agatcgagac catcctggct aacacggtga aaccctgtctctactaaaaa
11101 tacaaaaaat tagctgggca tggtggcggg cgtccatagt cccagctactcgggaggctg
11161 aggcaggaga atggcatgaa cccgggaggc ggagcttgca gtgagccaagatcacgccac
11221 tgcactctag cctgagcgac agagtgagac tccgtctcac aaaaaaaaaaaaaaaaaaaa
11281 attgaggcca ggcacagtgg ctcatgcctg tgatcccagc actttggccgaggcaggcag
11341 atcacctgcc atcaggagtt cgagaccagt ctcgccaaca tggcaaacccctgtctctac
11401 taaaaataga aaaattagcc gggcatggtg tcgggcacct gtaatcacagctactggggt
11461 ggctgaggca gaagaattgc ttgaacccag gaggcgaagg ttgcagtgagccgagactgc
11521 accattgcac tctaacctgg gctataagag cgagactctg tctcaaaaaaaaagcccttt
11581 acaaatatta actcgtttaa ttctcagaac acccctagga ggtgggtcctgctatcctgc
11641 cggttttgta gatgaggtaa ctgaggcaca gagaggataa gtcacgtggcccaggtcttg
11701 gtcgcttctc agcctccatt tccgagagga gaaaacaatg ctccgaaaggggaagtcatc
11761 ggcctgaggt caccagccgg gaaccggagg agccaggatg gggcccgaggtccatctgag
11821 gccagagcca gtgctgaccc gccagacagg aaatcagagc tggggactgaccgtggggcc
11881 cactcaagtg ggtggtgtgg ggtggtgacg ggggctgggg tgaaagccaggatgaggtgt
11941 cacattaggc tagggttcct gctgggcctg gcggggcaga gacccctggttgatgcctgg
12001 caagtctctc ctcatttctg ctgtgctgtc ccctgggtgg ccaaggcgccaggcccggct
12061 gtggatctga cacctcctgc tgccgagctc tgatcagaat ctggctgcagggcagggggt
12121 gaaactgaat cccaccaggc ctcccctggc ctggatgtca cggcagacatcccaacccca
12181 cttcttggca ctgcctgacc ccagcagtgg ccttcttgga acctggagagcctgtgccca
12241 ccctgtggtg ccgaccaggc tgctgccttg gccctgggct ctgggctccagggtccccag
12301 ggatcccagg cccaggctct tgcccctccc ggctctcagg tgagctgctgggatcgggtt
12361 cctgcggttt catgtctttc attgttcttg gctggggccc ggcttatgaaactgtaatga
12421 ggggcccctg ctcccgaagc cggcccctct aaggtttcca ctgcctcggcggctgctgcc
12481 accacagccc ggagtcgggg cctgggaggg cagcagtgtg ggggcctgagccggagcccc
12541 ccggggacga gggtgctgac agtcgacagc caccaccacc accagagcccgcagcccagg
12601 taatccgaga ggaggcgggg cgcagggtgc catggccgct gtctcccaccaccaggggag
12661 ggaactgccg ctctccagag gtggggagga attggggggg gccctggaggtgagcagccg
12721 ttcccccctg gtgagcccag caccagacca gccttcacag gtgtggccttgccaaaggtg
12781 gagggagaga ggagtgggca gctggctcta gcccccgccc ttttcctggggccttgaccc
12841 tccagccctg gatcccctgc ctctccttta gtggggcaaa tctcttctgtcctccaagac
12901 cttgctttcc catctcctct accatcaaac tgcctcttcc tccctcagacctctcccttc
12961 tctcagccag cctaatcctt cctcctcgcc cttgtctttt ggccgcaaaagaccctggtg
13021 gatccttcta tccacctcgt tctggggcgc acgcacatac atgcatgtatacatgaagtt
13081 gcactcatgc aaacgtacag atcggtgtac ccgcgggacc tgcgtagacacgcatgcgca
13141 agagctcgct ccacctatgt gcacacatgt gcccccaata ccaggcctttatccacacac
13201 atacctgctc caaggcccat atgtgtacac tcacgtgtgc aggcacacaccaggtacctc
13261 agccagccct cggcttgagt cccaaggggt gcttctagcc tgatgggcagctccttgaga
13321 agtgcaggat cccccgagga gatgcctgga gactcccacg ccaccgggaggggctgtgca
13381 gggggagggg agcccccacg tgggcgctga gctgtctcct ctctccaaccctggcccagg
13441 agctcaggag cccttcaggt gctgaggtgc cctactgcga cctgcctcgatgtccacctg
13501 cccctgagga cccactcagc gcctcaacct ccggctgcca gtctgtggtggacccaggcc
13561 tcaggccagg gcccaagagg tgggtagagt cccagggccc aggaagggcttcatggggtg
13621 gaatgccctc acccttccca tttgcactcc ttccccaagg cagcacctgtctctaatggc
13681 tgctggcatg ggtcacgtgg tcagtcctct aaacctaggc acaggtgggtggtgggcatg
13741 ctccttgggc ccacaggaag aactcagatc acaccaccct gtttgcacttcagtggctga
13801 gcctcccctc cccagtcctg gctgtctctc ccaggggccc tgcccaccccataacctccc
13861 aagaccgagc tcagctttgc cccagggtgt gtggctgctg tacactcaccttgcagtggg
13921 catggccaca gcctactcac atttcctggt tccctttgca cagctttaaaagattaaaca
13981 gtccctgcac ccaggggcac ctgctgtcac ccacctacgt gggtgtgcactgctccaggc
14041 tctggggttc cttccaccct caggcctgag tggcagtccc cctttaaggtcatggtacct
14101 tgggaggcca tggtctgaga gtctagaaac ctgggttcca gcttcagatccatccctgat
14161 gggtcttgag caagttactc tgtctttctg tgtctcagtt tccctctctgtaaaataaga
14221 gggattgaat taaatcagca ttgtgctggg atcattcatg tgctcctcacaggtaggcat
14281 attaaaacaa acaaacaaac aaaaaaacag cctgggtgca gtggctcatgcctgtaattc
14341 cagaactttg ggaggccaag gtgggcggat cacttgaggt caggaggtcgagaccagcct
14401 gaccaacatg gcgaaaccct gtctctacta actatacaaa aattagccaggcatggtggc
14461 aggtgcctgt aatcccagct gctcgggagg ctgaggcagg agaaccacttgaacccggga
14521 ggcagaggtt gcagtgagtt gagatcgtgc cattacactc cagcctgggtgacacagcga
14581 ggctccgtct caaaaaaaaa aaaaacaaca aaaaaaaaaa acaaaaaaaaacccacaaaa
14641 aaacgaaaaa aaaaacaaag acagctttgt tatcaagtat gtttcagaaagtctgggata
14701 aatgaagttg aatagctttc ctgcaggact tgtcagagcc tttagcttgcctgcgtgcat
14761 cgtggctttt gggtaacgga agtagagaag tatgtcattt gactacagagctctttttta
14821 tggccatcac ttattatcat cgtgtaggcc agtctgtggg tcactctttggggatactgc
14881 cagcgctaag ccttcttgag cctgtgactt cttttaaagc agagccttctctgcagctcc
14941 ctccctcagc atctgggcta gtgaacccgt caatgcctgt ggagccatgctgcctctcac
15001 atcctcgtta gccaagcatg agtctgtctt cttagactta ctgaacttggggtcagtaga
15061 ctaagactaa gacttaaagt tggggctggg gcaatagttt tggttcataacacagctctg
15121 ccctttccta tctcggtgac cttggccagt ctcttgacct ctctgagcctcagtgtcttc
15181 ctctgtgaaa tgggaattat tattattatt attattttga gatggcatcttgctctatca
15241 cccaagctgg agtgcaatga cacgatgttg gctcactgca acctcagcctcccgagtagc
15301 tgggattcca ggcatacacc accacacccg actaattttt gtatttttatttatttattt
15361 ttgagataga gtctcgtgct gtcacccagg ctggagcgca atggcacgatcttggctcac
15421 tgcaacctcc acctcctggc ttcaagcgat tatcttgcct cagcctcctgagtagctggg
15481 attacaggtg tgtgccacca ccatgcccat ctaatttttt tatttttagtagagacgggg
15541 tttcaccatg ttggacaggc tagtctcgga ctactgacct caggtgatccacccaccttg
15601 acctcccaaa gtgctaggat ttcaggtgtg agccactgcg cccggcctaaaatgggaatt
15661 attatactta ctttaaaggg atgctgttgc tgggcgcagt ggctcacgcctgtaatccca
15721 gcactttggg agtccgagac gggcggatca cgaggtcagg agatcgagaccatcctggct
15781 aacacggtga aaccccatct ctactaaaaa atacaaaaaa ttagccaggcgtggtggcgg
15841 gcgcctgtag tcccagctac tggggaggct gaggcaggag aatggcatgaacctgggagg
15901 cagagattgc agtgagccga gatggtgcca ctgcactcca gcctgggtgacagagcgaga
15961 ctctgtctca aaataaataa ataaataaat aaataaataa ataaataaataataaaatta
16021 caaaaaaaaa agggatgctg ttttagctca atgaggcaat ccatataaaaagtctgacac
16081 agaggcagct ctcaccattg gctccctttc ccacaccagc gtgtgggccccaggctccct
16141 gtgtgagtga gtgcatatgc ctgggtgggg tgggggatgc tcctaactccccattacttt
16201 ttgggtctgt ctcctctccc aggggcccat ccccctcagc agggctcccagaagagggtc
16261 ccacagctgc ccccaggagc aggagccggg agcttgaggc agtaccctatctggagggcc
16321 tgaccacttc cttgtgtggc agctgcaacg aggaccccgg ctctgaccccacctccagcc
16381 ctgactccgc cacccctgat gataccagca actcgtcctc tgtggtgagccaggagtggg
16441 agtttggggg acaagagtgg ctcacacctc catctgcagc cctgggtcccacctaaacct
16501 ccaggccagg gctgagcctc acaccaggga atccgacgag gtcctctggaccattagctg
16561 gcagctcggg ccaccccggc gaacccctgg agagtgggga tttctgcacaggctggccca
16621 gggcagctgg ggtctggctg tgaaaagaca gggaaaggag tttcagccgacaggagctct
16681 gggtgaatca ccagcaggct cgggctgcca catgctctca gatcccagagtgttgggttt
16741 ggtgtctagc gcaagagtgg cacagggccc cagggccctg ccctcgacacacagtgctga
16801 gtcccatggc cagccctgga atagatttcc aagagacaga ggaaagggagcaggctgcgg
16861 gggtcattta accacgaaaa gagaagagcc agcagtcttt cctccagcatttgcattttg
16921 aggggctgcc gcagagcaga agagacaggc ttgtcccagg agaccccccaaaaggaaaat
16981 gacagggggt ggtgataaga ctcagaataa aacaacccag cctcacacgcttcatggcca
17041 gctccatgct aagggcttgg tgggtgtggg ctcaggggag actcaccacagcctcagaag
17101 tggagatttc agtcgcccca tatggggctg aggctcagcg gggggagcaacttagtggag
17161 gccacacatc tgggaagtag tggggctagg atttgaaccc acttttctctggcccctggg
17221 gctacctcac acagtcccac atgcggaact ctgggactct gggcaaagctcttggcttca
17281 atggatgtac atgcctccta ggtccgttga agatgagcga cttggcacttagcacctgct
17341 agagcccagc acagtgccag gcaaacagca catgctttta atttaattgattgattgaag
17401 actgggtgcg gtggctcacg cctgtaatcc cagcactttg ggaggccaaggtgggcggat
17461 cacctgaagt caggagatcg agaccagcct ggccaacatg gtgaaactctgtctctacta
17521 aaaatacaaa aattagcagg gtgtggtggt gggcacctgt aatcccagctacttgggagg
17581 ctgagacagg agaatcgctt gaacccggga ggttgcagtg agcttagattgcaccattgc
17641 actccagcct gggcaacaag agcaaaactc cgtcttaaat agagaaaaaaaaaaaagttg
17701 attgattgag acagggtctt gctccattgc ccagactgga atgcaatgatgtgaacatgg
17761 ctcactacag ccttgacttc ctgggctcaa gtgatccccc cacctcagcctcctcagtag
17821 ctgggactat aggcatgcac aaccatgcct agttattatt attttttttaattttgtaga
17881 gacagggtct cactgtgttg cccagcctgg aagtgctttt tactgaggccatggagcgga
17941 gtctacacca cagaaggtgt ggcaccactc actgtcacct cttggggacagaacttgaca
18001 gtttaggaag tgctttttat tttttattta attttattta tttttgagatggagtcttgc
18061 tctgtcacct gggctggagt gcagtgccac aatctcagct cactgcaacctctgtctccc
18121 aggttcaagc gattcgcctg cctcagcctc tcgagtatct gggattacaggcgcccacca
18181 ctatgcctgg ctagtttttg tatttttaat agagacaggg tttcaccatgttggccaggc
18241 tggtttcgaa ctcctgccct caggtgatcc acctgcctca gcctcacaaagtgttgggat
18301 tacaggcgtg agccactgcg ccctgcaggg aagtgctttg tttttttttgttttgttttt
18361 ctttttgttt tttgagacag agtctcactc tgtcacccag gctggagctcagtggcgcga
18421 tctccactca atgcaagctc cacctcccag gttcacacca ttctcctgcctcagcttccc
18481 aagtagctgg gactacaggt gcccgccacc acgcccagct aattttttgtattttttagt
18541 agagatgggg tttcaccatg tttcccagga tggtctcgat ctcctgacctcgtgatccac
18601 ccacctcgtc ctcccaaagt gctgggattg caggcgtgag ccacagcgcctggccaggga
18661 agtgcttttt aatgccaatt cccttccctt ccttctgccc ctctcatttggagagtatat
18721 gtcctgcagc cttttttctc ccgcaaacat actttctcct ccccttctctggcaggactg
18781 ggacactgtt gagaggcagg aggaggaggc ccccagctgg gacgagctcgcagtgatgat
18841 cccgaggagg cctcgggagg ggccgagagc tgacagctcc caaagggctccgtctctcct
18901 caccaggtcc cctgtgggag gagatgctgc aggccagaaa aaggagggtgagtccttctg
18961 ccaggttggt tcccatggtg atggcctggg gccccccaga tagccatctcactggccatt
19021 tgggactctg ggcacggctt actttggtgg cctgagtgtt aataatagtaacagtttgca
19081 tgtcatgatg gagcagccac aatgagttat gctacccact ttaattattattattattat
19141 ttgggatgga gtcttgctct gttgcccagg ctagagtgca gtggtgtgatctcggctcac
19201 tgcaaccttt gcctccccag ttcaagcgat tctcctgccc cagcctcccaagtagctaag
19261 attacaggct cccgccacca tgcccagcta atttttgtct ttttagtagacatggggttt
19321 caccatgtta gcccagctgg tctcaaactc ccaaccttca gtgatctgcccatcttggcc
19381 tcctaaattg ccgggattac aggcgtgatt acaggcacgc ctagcctgttattattatta
19441 ttattactat tattattttg agataagagt ctcacactgt tgcccagactggagtgcagt
19501 ggtgccctct tggctcactg caacctccgc ctcctgggtt caagagattctcctgcctca
19561 gcctcctaag tacctgggat tacaggcacc cgccaccaca cgtggctaatttgtgtattt
19621 ttagtagaga cagggtttca ccatgttggc cgggcttgtc tcaaattcctggctggggat
19681 tacaggagtg agccactatg cctggcctta gccaaggagt ttggacttctctaaatagta
19741 gggagccacc gaaggttttt gaggaggaaa gtcatgtaat taaacctgtgcctcaggaag
19801 ttccctagat caaagatgca aaggatgaat tggagcaggg aggggttgaaggatgagaaa
19861 ccagttaaga gactgttgca ggcactgtag caataactgg ttcaggcatgaatcactggc
19921 ggatgcaaaa tccctagggt gataatttgt cagcaaacag gatagtcatggtttcaaagt
19981 attgtgtccg gaattggtgg gttcttggtc tcactgactt caagaatgaagcggcagacc
20041 ctcgcgatat tacagttctt aaaggcggcg tgtctggagt ttgttccttctgatgttcgg
20101 atgtgtttgg agtttcttcc ttctggtggg ttcgcggtct cgctggctcaggagtgaagc
20161 tgcagacctt tgtggtgagt gttacggctc ttaaggagac gcgtccgcagttgttctttc
20221 ctccctgtgg gttcatggtc tggatggctt caggagtgaa gctgcagaccttcgtggtga
20281 gcgttacagc tcataaaggc agtgtggacc caaagagtga gcagcagcaagatttattgc
20341 aaagagcgaa agaacaaagc ttccacagca tggaagagga cccgagcgggttgccagagc
20401 tggctggggc agcctgcttt tattctcttg tctggcccca cccacatcctgctgattggt
20461 ccattttaca gagagccgag tggtctgttt tgacagggcg ctgattggtgcatttacaat
20521 ccctgagctt gacacaaagg ttctccacat ccccactaga ttagctagatacagtgtcca
20581 cacaaaggtt ctccaagtcc ccaacagagt agctagatac agagtgtggattggtgcatt
20641 cacaaaccct gagctagaca cagggtgctg attggtgtgt ttacaaaccttgagctagag
20701 acagagtgct gattggtgta tttacaatcc cttagctaga cataaaggttctccaagttc
20761 ccactacact caggagccca gctggcttca cccagtggat ctcgttctggggctgcaggt
20821 ggagctgcct gccagtccca tgccatgcgc ccacactcct cagcccttgggtggttgatg
20881 ggactgggcg ctgtggagca ggggcggcgc tcatcgggga ggctcgggctgcacaggagc
20941 ccacggaggc ggggggaagc tcaggcatgg cgggctgcag gtcccgagccctgcccggtg
21001 ggaaggcagc taaggcccgg cgagaaatcc agcgcagcgc tggtgggcgggcactgctgg
21061 gggacccagc acaccctccc cagccgctgg cccaggtgct aagcccctcattgcccgggg
21121 ccggcagggc cagccggccg ctccgagtgc ggggcccacc aagcccacgcccacccggaa
21181 ctccagctgg cccacaagcg ccgcgcgcag cctcggttcc cgctcgcgcctctccctcca
21241 cacctccgtg caagctgagg gagccagctc cggcctcggc cagcccaggaaggggctccc
21301 acagtgcagc ggtggcctga agggctcctc aagtgccgcc aaagtgggagcccaggcaga
21361 ggaggcgccg agagtgagcg agggctgtga gggccgccag catgctgtcacctctcagta
21421 tcacccctca gattctgcat cgattactga gagaaaggca cccttaggctggggagagcg
21481 ggaagatacc actttcacca agaggctgct cagcatcccc agagtggggcaaaccaacat
21541 aatatgcccc ctgatatgat gcatggggtc aggggagggg atgctggggtgggcacagaa
21601 tcccttccct tctaaatcgt cctgctgaaa atgcattgcc tacacctaaccccagtgaaa
21661 catcagacaa acccgaattg aaagacattc tgcaaaatga ctgggctcctcataggacaa
21721 aaagcggcta ggggactctt cttgattaaa agagactaac aggatgaggacgtggaatgc
21781 catgtgtgag cccattggga tctgggacag gaggacacag agctgtgacaggcattactg
21841 ggacaactgg ggcttgtttt tttttttttt tttttttgag atggagtcttgctctgttcc
21901 ccaggctgga gtgcagtggc gcgatctcag ctcattgcaa cctccacctcctgggttcaa
21961 gcgattctcc tgcctcagtc tcctgagtag ctgggactat aggtgcctgccaccacgccc
22021 agctgacttt ttgtatttct agtagagaca gggtttcacc atgttgagcctgatgggatc
22081 cgggacacgc ctatagtccc agttactcgg gatgctgagg caggaggatcgcttgaactt
22141 gggaggtgga ggttgccgtg agctgagatc gccccactgc actcccgcctgggcaacaga
22201 ataagactcc atctcaaata aataaataaa taaataaata aataaataagggccatggtt
22261 gtggggtgag gaggggacag agaaggagag aggtttagga ggcagacttgatggtacttt
22321 ggacaggagg atacacagtc acagctcctg gcctgggtgt ctgggtagatggtgtgccct
22381 ttgctgagag caggtggctg gggagcggat gggcccagcg ctggctgtgctgtgtgggat
22441 ttgcgagccc tgaggaagag gttttgaggc ttcagatgct cagggaagcaggggatggag
22501 atgtggcatc ttcaactgag gagcaatgtt cactcaggca ctcagcagacgtttacttac
22561 tgcccacaag tcaatcatgg ctgaatagat gaggcagcaa tgagaacagcagcagcatta
22621 cagcagtgac ctgttttttt gatgttccag gccttgtgct aaataaatgtcttgcacaga
22681 atcactctgg gctccccgat ccctcactcc tggtctgcct ccttcctcacgggccactcc
22741 acctcgctct cctttgctga ggccgcctcc tctgcttcac ttttaaatatctgatgcccc
22801 acatcccagt cctgggcccc ttctgtcttc tccctgcaca cttagctgcttggctttcgg
22861 tactgtctgg gaaaaaccat gactccggag tccacatctc tggccttgatttctcccctg
22921 aacctgccaa tttatacaac ccagccctct actgcgttaa tcacacctcaggccccacac
22981 tgcactcact gtttcactca tccccccccg cccttttttt tttttttttttttttttttg
23041 agacagagtt tcactcttgt tgcccaggct ggagtacaat ggcgcagtctcggctcactg
23101 caacctccac ctcccaggtt gaagccattc tcctgcctca ggctcccaagtagctgggat
23161 tacaggcatg caccaccacg cccggctaat tttgtatttt tagtagagacggggtttctc
23221 catgttggtc aggctggtct cgaactcccg acctcaggtg atccgctgatccgcctgcct
23281 cggcttccca aagtgctggg attacaggcg tgagtgaccg tgcccggcccactgctacaa
23341 tactattaac taagctacag acgtgatggg attcaccagt ttttctactaatatcctttt
23401 tctgttccag gatccattcc aggatcccac attgccttta gtccctctcctcatctcctc
23461 cgtctcctcc aatctgtgac aggtttccca tctcttccag tttcccctgaaggctggggg
23521 cacagcgatc tgctcacctt tgactttaaa aaaagtctcc ctggatgaacaatgacattg
23581 gccccagagt gcccaggctt gggggctact gcaaccatcc aggagagaaatagtggtggc
23641 ttggagtagg aagtgggtgt agatgagaga aacaggtgaa tatggaatgtatttatttta
23701 tttttcgtag agatgggggc tcactatgtt gcccaggctg gtctccaactcctgggctca
23761 agcaatcctc ctgcctcagc ctcccgaaat gttggaatta caggtgtgagccactaccag
23821 gcatgaaacg tattttagaa tgccatggga catcagccac cagcaattttttttgttttt
23881 tgttttctga gacagagtct cgctctgtca cccaggctgg agtgcagtggccagatctca
23941 gctcactgca acctccacct cccgggttca agcaattctc cagcctctgcctcccgagta
24001 gctgggatta caggcatgca ctactgcatc cggctaattt tttttttttttttttgtatt
24061 tttagtagag atggggtttc accgtgttag cagggctggt atcgatctcctgaccttgtg
24121 atccgcccgc ctcggcctcc caaagtgctg ggattacagg catcagccactgctcccggc
24181 tgcatccagc taatttttgt atttttagta gagactggtt tcaccatgttggccaggctg
24241 gtctcgaact cctgacctca gatgatccac ccgccttggc ctcccaaagtgttagcatta
24301 caggcgtgag ccaccgtgcc tggcaacctt gcaaattttg aattccctgctaggtgctgg
24361 gaactcagac tttcaccaac accagcccag agaggctgga cgaggcagtggctgcaaagg
24421 gagaggacag gggatcttaa gaaggcgtga agggagggga tctgcatgaaggcaactgtg
24481 gctacttttt tgtttcgttt tttgttttaa gacaatgtct tgctctgttgcccatgctgg
24541 agggcaatgg cacattcttg gctcactgca acctccacct cctgggctcaggcactcctc
24601 cggcctcagc ctcctaggta gctgggacta caggcacgta ccaccaggccctgctaagtt
24661 ttaaaaaact tgtagtagag acagggtctc gccatgttgc ctaggctggtctggaactcc
24721 tgagctcgag tgatcctccc accttggcct ctcaaagtgc tgggattacaggtgtaagcc
24781 accacaccca tagttgtggc tcctttaaga tgaggccatg ataccctttactcttcacct
24841 aaagcagtag ccaagggaca tgtacatagg ggtgctcaac acctgcttggtgaccgaggg
24901 attgagcggg gtggagggtg acacaccaag gtcatggcaa ctctgtcatgaggctaggag
24961 ttgcaaagag ggtcactact gaggacagtt acattaatcc tttaggccagtgcttctgaa
25021 actataaggt gtacaaatca ccagacagtt ttgttaaatg cagatccagaagcagtgcat
25081 ctgggctggg acctgagatt ctgcatttct ggcaaactcc cagctaccagtttataaaag
25141 gttgtccatc cctgcacctt tcctatcctc atggcagccc taggagaagcctcagggtag
25201 gaacatttgg atacaaaaaa acaggggctt tctagagctg tcgcacaggaaacaggctca
25261 ttagaacctg tctctactaa aaacacaaaa atgagctggg catagtggtgcatgcctgta
25321 atcccaacta cttgggaggc tgaggcagga gaatcatttg aacccaggaggcttaggttg
25381 cggtgagccg agatcgcgtc attgcactct agcctgggtg acagaacgagactctgtctc
25441 aaaaaaaaaa aaaaaaaggt cgggcatggt ggctcacgcc tgtaatcccagcactttggg
25501 aggccgaggt gagcggatca cctgaggtca ggagttcgag accagcctggccaacatggt
25561 gaaaccccgt ctctactaaa aatacaaaaa ttagctgggc atggtggcgcatgcctgtaa
25621 tcccagctac tcgggaggct gaggcaggag aatggcttga acctgggaggcggaggttgc
25681 catgagccga gatcacgcca ctgcactcca gcctgggcga cagagcgagactctgactca
25741 aaaacaaaac aaaacaagaa atggggggaa ttccttggat tctgattgaaggaaatagaa
25801 ctgggaaggg aagactgtca ggtggctgct gttgggccca cctctccctccctggggtca
25861 cacaggccat tgtcaacact tctctccaca aatttgcttc ttctctgtcttgtccgtgga
25921 tccccagacc ctgtggcctt ccagttcttg aacccatctc ttgagtgagtcagggtctca
25981 atttcaaatt cttgacctca gcttgagaga ggcatccaag cccttgtctaatcagccttg
26041 gtcagagagg tggagtcact tggtacagac agtgagacct gtaggaggagggtgtggggt
26101 ttgccctaat cactggtcct aagggacaaa gaaaggtaga atatgagagctgcctggacc
26161 tctcccctta ccttgagccc ctctcttctc tctccagaca ccggcggtgggggccggagc
26221 gcaggacagc actgggcaag gctccgggga gaaagcgggt tgtccctggagcggcaccgg
26281 tcaacactga cccaggcttc ctccatgaca ccacacagtg gacctcgaagcaccacgtct
26341 caggcttctc ctgcccaaag ggacactgct caggctgcct ctacacgtgaaatccccaga
26401 gcctcctctc cccatcgaat cacccaaagg gacacctcca gggcctcatccacccaacag
26461 gaaatctcca gggcctcatc cacccaacag gaaacctcca gggcctcatccacccaagag
26521 gacaccccta gggcctcatc cacccaagag gacaccccca gggcctcatctacacagtgg
26581 aacaccccca gagcttcctc tccctcacga agcacccaac tggataaccccagaacctct
26641 tctacccagc aggacaaccc ccaaacttct tttcctactt gtactccccagcgggaaaac
26701 cccaggacac cctgtgtcca gcaggacgat cccagagcct cctctcccaacagaaccact
26761 caacgagaga attccagaac atcctgtgcc cagcgggaca atcccaaagcctccagaacc
26821 tcctctccca atagagccac acgagacaac cccagaacat cctgcgcccagcgggacaat
26881 cccagagcct cctctcccag tagagctaca cgagacaacc ccacaacatcctgtgcccag
26941 cgggacaatc ccagagcctc cagaacctcc tctcccaata gagccacacgagacaacccc
27001 agaacatcct gtgcccagcg ggacaatccc agagcctcct ctcccagtagagctacacga
27061 gacaacccca caacatcctg tgcccagcgg gacaatccca gagcctccagaacctcctct
27121 cccaatagag ccacacgaga caaccccaga acatcctgcg cccagcgggacaatcccaga
27181 gcctcctctc ccaatagagc tgcacgagac aaccccacaa catcctgtgcccagcgggac
27241 aatcccagag cctccagaac ctcctctccc aatagagcca cacgagacaaccccagaaca
27301 tcctgtgccc agcgggacaa tcccagagcc tcctctccca atagagctacacgagacaac
27361 cccacaacat cctgtgccca gcgggacaat cccagagcct ccagaacctcctctcccaat
27421 agagccacac gagataaccc cagaacatcc tgtgcccagc gggacaatcccagagcctcc
27481 tctcccaaca gaaccaccca acaagacagc cccagaacat cctgtgcccgacgggacgat
27541 cccagagcct cctctcctaa cagaaccatc caacaagaga accccagaacatcctgtgcc
27601 ctacgggaca atcccagagc ctcctctccc agcagaacca tccaacaagagaaccccaga
27661 acatcctgtg cccaacggga cgatcccaga gcctcctctc ctaacagaaccacccaacaa
27721 gagaacccca gaacatcctg tgcccgacgg gacaatccca gagcctcctctcgcaacaga
27781 accatccagc gagacaaccc cagaacatcc tgtgcccagc gggacaatcccagagcctcc
27841 tctcctaaca gaaccatcca acaagagaac ctcagaacat cctgtacccgacaggacaat
27901 cccaggacct cctctcccaa tagagccaca cgagacaacc ccagaacatcctgtgcccag
27961 cgggacaatc tcagagcctc ctctcccatc agagccaccc aacaggacaaccccagaact
28021 tgtattcaac agaacatccc cagatcatct tctacccaac aagacaaccctaaaacctct
28081 tgtaccaaac gagataacct cagacccact tgtacacagc gggaccgcacacagtccttt
28141 tcctttcaac gagacaaccc tggaacctcc tcatctcaat gctgcacccaaaaggagaat
28201 ctgagaccat catctcccca ccgctccact caatggaaca atcccaggaattcatctccc
28261 catcgtacta acaaagacat cccctgggcc tcgtttcccc tccggccaactcagagtgat
28321 ggtccccgaa cctcttcccc atctcgctcc aagcaaagcg aggttccctgggcatccatc
28381 gccctccggc caacccaagg tgacaggcct cagacatcct ctcccagcaggccagcccag
28441 catgacccac cccagtcctc ctttggcccc acccagtaca acttgccatcccgggccacc
28501 tcttcctccc ataacccagg ccaccagagc acctcccgaa cttcctcacctgtgtacccc
28561 gctgcctatg gggctcccct gacctctcct gagccctccc agcctccatgtgctgtgtgc
28621 attgggcacc gggatgcccc tcgagcctct tcgccccctc gctatttgcagcacgacccc
28681 ttccccttct tcccagagcc ccgcgcccct gagagtgaac cgccccaccacgagcctccc
28741 tatataccac ctgctgtgtg cattggacac cgagatgccc cccgggcgtcctcgcccccc
28801 cgccacaccc aatttgaccc cttccccttc ctcccagaca catcagatgccgagcatcag
28861 tgtcagtccc cccaacacga gccccttcag ctccctgcac ctgtgtgtattgggtaccga
28921 gatgcacccc gggcctcctc cccaccacgc caggccccag agccttccctcttattccag
28981 gacctcccca gggccagcac agagagcctt gtcccttcca tggactctctgcacgagtgc
29041 ccccacatcc ccacccctgt gtgcattggg caccgggatg caccctccttctcatcccca
29101 ccacgccagg ctcctgagcc atccctcttc ttccaggatc cccctggaactagtatggag
29161 agcctggccc cctccactga ctctctgcat ggctccccag tgctgatcccccaagtgtgc
29221 atcgggcacc gggatgcacc ccgagcctcc tccccacccc gccacccacccagtgaccta
29281 gcgttcctgg caccctcacc ttcaccgggc agctctgggg gctcccggggctcagcgcct
29341 cccggggaga ccaggcacaa cttggagcgg gaggagtaca ctgtgctggccgacctgccc
29401 ccacccagga ggctggccca gagacagcca gggccccagg cgcagtgcagcagcgggggc
29461 cgcacccaca gccctggccg tgcagaggtg gagcgcctct tcgggcaagagcgcaggtga
29521 gcccgggggt ggggtcagcc aggtgggctg gggaggaggc tcggcagcaggacaggtgaa
29581 gggttagggt gccaaaagaa agtgttcaaa tccccctggc ttgccatttaccggctgtgt
29641 gaccttgggc aaatcgctcc atttctctgt ttctgcatat tgggagttttctgttttgtg
29701 tgtgtgtgtg gttaagtgat gtcatgcaca gcccagtggt taacagcaaagactgcagtc
29761 aggagggctg agtccaaatc ctgggtcaaa gccacatgtc aactcgtatgacctgatata
29821 gtgagttaac ctacctgagc ctcagtttcc tcatctgtaa gggaggggaacatgagcaca
29881 ttcattcaaa taagggtgaa ctgtcttttt attttttatt ttttgtttttttttttgagg
29941 tggagttttg ctcttgttgc ccaggccgga gcgcaatggt gcaatctcggctcactgcaa
30001 cctccacctc ctgggttcaa gcgattctcc tgcctcagcc tcccgagtagctgggattac
30061 aggcacgtgc caccacaccc ggctaatttt tttgtatttt tactagagacggggtttcgc
30121 catattggcc aggctggtct cgaactcctg acctcaagtg atccacccgcctcggcctcg
30181 caaagtgcta ggattacagg agtgagccac cgtgcccggc caaaatgagagtgaactctc
30241 aaaccctttg atccagactc atgggttttt tttttttttc ttccgtgcatgagggagaag
30301 aagaaagtac ccatgatttt ttcctgcctt ggcaaagaaa actcatgggtccctatgcat
30361 ttcagaaaac agttatgtca atttaaaatg tatggccagg gccgggcacggtggctcatg
30421 cctgtaatcc cagcacttgg ggaggccgag gcgggcggat cacaaggtcaggagatcgac
30481 agcagcctgg ctaacacggt gaaaccccat ctctactaaa aatacaaaaaattagctggg
30541 catggtggcg ggcgcctgta gtcccagcaa ctcgggaggc tgaggcaggagaattgcttg
30601 aacctgggag gcggagcttg cagtgagccg agatcgtacc actgcactccaacctgggtg
30661 acagagtgag actccatcta aaaataaaaa taaaataaaa atgtatggccagagctacct
30721 attttaagaa agaaagctca cagaattatg gatttttagc agtcaaacatcctgggacac
30781 ctgaagtcca ggtgtctttt gagtctcctt ggtcagcagc actggccccctggaagggga
30841 gcatttcctc ctgatcaggc tgaggtttct ctccccagaa gttccagccctcgagttttc
30901 aagaatcaga gctagaattc cattagttag ggtcaagaga acaacagcaacaaaaagcag
30961 tctggaagtc tcaaaacttt ccatgtatat aattcaacga atttttagtttatttaccaa
31021 gttgtccaac cattgccaca atctaacttt agaacatttt catcaccctaaagggtatgg
31081 aatattttgt atctaaaatt cctctttgct gctccttggg aaagttttctcctggatttg
31141 aatctgcatg agaaacctta tcagtcttgg ctgggtgcag tggctccctcctgtaatccc
31201 agcactggag cttgcagtga gccaagatca tgccactaca ctccagcctgggtgacagag
31261 tgagactccg tctcaaaaaa aaaaaaaaaa aaaaaaatta gccgggcatagtggcacacg
31321 cctgtagtcc cagctactca ggaggctgag gcagcagtat tgcctgaatttgggaggtgg
31381 agtttgcagt gagctgagat tgcgtcattg cactccagcc tgggcaacaagagtgaaact
31441 ccatctcaaa aaaagaaaaa aaagaaactt tatctcttgt tcttcaaatttccttttcca
31501 gtaagcttga tcatttaata tccagatgac aaccgtgtgg tctccagcattagtataatt
31561 ctttctttgg ccttaaaaac aaaaacccag agcagtttta ggtttacagcaaaattgagc
31621 agaaagtgca gtgttccatg cacagcctct cccactacca atatcctgtactagataggt
31681 atgcttgttt ccagctcctg gcctcaaggg atcctccttt cttggcctctcaaagtgctg
31741 gtgagccact gtactgggca gtagggtgat acatttgtta caatccatgaacctacacta
31801 tgaaatcacc caaagtttag ggttcactct tggtgatgta cagcctataggcttgaatga
31861 atgtatgaca agtatccacc attgtaacat catggagtag tttcaccctgaaagtcttca
31921 gtgtctttaa cttttttttt tgtttggaga tggagtctcg ctctgtcacccaggctggag
31981 tgcagtagtg caatcttggc tcactgcaac ctctgccttc tgggttcaagcagttctcct
32041 gcctcagcct cccgaggagc tgggactaca ggagcatgcc gccacatccggctaattttt
32101 ttgtattttt agtagcgaca gggtttcacc ctgttgccca ggctagtcttgaactcctga
32161 gctcaggcaa tctacccacc tcggcctccc aaagtgctgg gattataggcgtgagccacc
32221 gtgcctggtc tgaccttttt tttttttgaa acagggtctt gctttgtcacccagcagtag
32281 tgcagtggcg tgatcatggc tcactgcggc ctcaaactgc caggctcaagcgattctctc
32341 acctcagcct cctcagtagc tgggactaca ggcgtgtacc actatacccagctaattttt
32401 ctactttttg tagagatgga gtctcacttt gttgcccagg ttggtctcaaactcctggcc
32461 tcaagcaatg ctcccacctt ggcctcccaa agtgtctttg acctttttatgattactatt
32521 tcttgtctaa tgtcaatttt cctaactttg tcttaactaa taactcagcagggacattaa
32581 ggtctttaag ccaaagttaa ttaattttct ttcctttttt ccaggataatttcagagaga
32641 taaggtgttt atattaataa tagaaatgag aaatatgttt acacttttattaaccatttg
32701 tttttacacg atcactccta tacatttaat tctactctct ttgaaatagcttatttacct
32761 tttagggaag ttttcataat tttactgaat aattaaaatt tttcctcttatctggcacct
32821 tttccaagta gaaaaccatt catcctctga atatggaaaa ttttaaaactgtgcagtgtg
32881 tgtgtaaggg acagactgga gcttatgagc gggtggctgt aggagtgtgcttttattttc
32941 tcctatttcc tcatcgatat gtatttattg agcatctact ctgtccaagcattgtcccga
33001 gtctggaaaa tttttcttaa agggttgtca catcaaagca ttgggagttttggcttgatc
33061 ttaatttttt tttccttaga tgcctttggc atctcttaga gtcacgtagcatcctgtggt
33121 catttgaatt caaaacctag ccttcactgg atttgctaga cttgatggctttgctccttt
33181 aattctctct ggaggtcgaa gaacccatct aagcttccga aggaaacgtttcctttgtca
33241 tgcttggtgc ggccacatca accctcggga acaggtggcc ccgaggagacgctgttgctt
33301 cagcatcgga caagccaggt ctctgttggg gtttcagaat cttcttgagtccctcactct
33361 tttctctcag ttctacatgg gggaaaaaag gaaggcgagt tctcaggaggaatgctcatc
33421 aagcaagctg gagttcgtat ggaaaatgca tccatccgga agagaacacacaagtgcctt
33481 gcttccctgc accgggtgtt tccactattg tcctcctggt cctccccattagggaggaac
33541 agcccactgg gtcacgtctg ggctcttgct tcatcgaagc tcctataccccagttcgggg
33601 gaaaattcac tctaaggcct tcagctctca cagagtaagg aaacgcactcacctccaatt
33661 agattacaaa ttggctgggt gcagtggctc atgcttgtaa tgccaagactttgggaggtc
33721 aaggcaggtg gattacctga ggtcaggagt tcaaaatgag accagcctggccaacatggt
33781 gaaaccccgt ctctactaaa aatataaaaa ttagctgggc atggtggtggacacctgtaa
33841 tcccagctgc tcagcaggct gaggcaggaa aatcacttaa aaccagaaggcggaggttgc
33901 agtgagctga gattgcacca ctgcactcca gcctgggtga cagagcgagactccatctca
33961 aaaaaaaaaa aaaaaaaaaa gttacaaaca gcctgcccag ggagccctcaagctcagaaa
34021 cacttcctcc agggaacttt ggttcctctc cgaaccagct gccaataactgctaacaact
34081 aacattattg tgctttatgg ctctgattct aatgacattg gcaaaagacatgaaacaaca
34141 aaaaactcca accccatact ttttttttga gacaggatct tgctctttcacccaggctgg
34201 aatgcagtgg catgatcatg gctcactgca gcctcaacct cccaggctgaagcgatcctc
34261 ccacctcagc ttcccaagta gctgggacta cagccacgta ccaccatgctcggctcatta
34321 aaaaaatttt tttttcctag aacaaggtct cattctgttg ccagggctgtctcaaactcc
34381 tcgactcaag tgatcctctg acctcagcct ccccaagtgc tggaattacaggtgtaaaga
34441 cactgtacct ggcctcccaa ccccatatat atatatatat attttttgagacagggtctc
34501 actatgtcac ccaggctgga gtgcagtggc gcgatctcag ctcactgcaacctccacctc
34561 ctggggtcaa gcgatcctcc tgcctcagcc tcctgagtag ctgggattacaggcacgtgc
34621 caccacgcct ggctaagttt tgtattttta gtagagattg ggtttcactatgttgaccag
34681 gctggtctcg aactcctgac ctcaagtgat ccacccacct cagcctcccaaagtgctgtg
34741 attagaggca tgagccacca cacctgggct aatttttgta tttttagagactaggtttca
34801 ctatgttgtc taggctggtc ttgaactcct gagctcaagc catccgcctgcctcagcctc
34861 ccaaagttct gggattacag gcgtgaccca ttgcgccctg cccaatcccatacttttgaa
34921 ggtgtcgttc cagcatggct cctcaggcac aggcccacca cagacagcagggcctatgga
34981 ggcctgagca gagtttcctc atacttccct ttttgctgcc tcactctgggtccaccacag
35041 ggtggccttt ttcaggcttc tcttcctggt tcagttcatc gaccaaagacatggctccat
35101 ttgctaactg agacccaacc aaaataaaca ttcatggagt ggttgggccttttgttgtga
35161 ccccttaggt agaggaaggg agagatatgc ccaggttctg tttggtgtttctacctgtca
35221 atagagatac cacgttaatc attaacagcc atgcctccca gttagtaagcaagacaacta
35281 actggaacta gactttttac acaagttaga gatgatcttc atcggatgcgtcaacaatgc
35341 ctgaagccca gtgtcttaga aacaacactt gcccagggtc aggcgtggtggctcatgcct
35401 gtaatcccag ctacttggga gattaaggca gagaatcact tgaacccgggagatggaagt
35461 tgcagtgagc cgagatcgcg ccactgcact ccagcctggg tgacagagcgagactccatc
35521 tcaaaaaaaa aaaaaaaaaa aagacacttg cttggacagt ttatgttggcctctctgaag
35581 ttgtcaggga gaatgtttct ttcttctgat cttgctcaga gctcttttgccaacagctag
35641 gatggcctgg agttttcaag gctaagcgct gggattctgt tggttaacagtgatgggagg
35701 gaaaaaggaa aagaaatcca aaatttacaa tatggacagg aaaaggcagaaagaatggaa
35761 cacgggggca cacagcagtc tggctctgtc gtcccacctc gtgggctgcgatcatgatac
35821 aagtgcttgg cccctggaac ataagaagca ctcaataaat gctttgtcataatgattatg
35881 tgtgcccagt gcctggtaca cagtaggtgc tcaataaatc ttaattcccgcaaagaccag
35941 tctaaccttt gtctgggggt ggctcttggg ctgctggtgg ggtggtggttagtcatagga
36001 agtactggat gagacaggag agggccatgg ccagggccag atccccctccccacccaacc
36061 gcctctactc cccacttttc tcgtcatgtt cgcaagagcc tcatgaggcagaatagagca
36121 gtgttaacca tccccatttt tcagaagggg aaactaaggc cctgagagtcatcctcactt
36181 agggcccttc aacgagcttg cagtgggtcc ctggctgtcc cacatctcctcctgttggag
36241 gtgggagcag aggggctggg gtgctgggag tgggacagtc cctcagaggagtggctgcat
36301 ttgctcatag gaagtccgag gcagcggggg ccttccaggc ccaggacgagggacggtcac
36361 agcagcccag ccaaggccag agccaacttc tccgaagaca gtccagccctgcccccagca
36421 ggcaggtgag cactgccagc tgtctggggc cccgcacccc aaggggcggccactgcctct
36481 tccctcccgc tagaagccag gcagggggct tggacaggaa ggtcctctatgaaagggtcg
36541 gagtccaatc atggggatcc agctctcccc tctccccaac ggccagcagctcttggcaaa
36601 atgcacaaga ccccacatta atcctttgaa gatagcccct ctcccacgctatccccttcc
36661 tttactaagc actgctgtct tttttttttt tttttttttt tgagatggagtcttgcactg
36721 tctcccaggc tggagtgcag tgggacaata ttggctcact gcaacctctgcctcccaggt
36781 tcaagtgatt cttctacctc agcctcccaa atagctggga ttacaggcgtgtgccaccac
36841 acccaactaa ttttcgtact tttagtagag acagggtttc accatgttggccaggctggt
36901 cactcctgac gtcaagtgat ccgcccacct tggcctccca aggtgctgggattacaggcg
36961 tgaaccacgg cacctggcca atactgctgt cttgagcaga tttcagggaaagccttgaag
37021 caagaatctg gctctaaggg ccctctcttt cagggtaatt tgtatctttaaccaaaccca
37081 gagggctagg cccgcctcag tggaatgggg tattggtggt ggaggttctggcacctgata
37141 gcccaagttg gaatcagtat ctttgagagg ggtgagaagc caagaacgggggcaggtctt
37201 tgcagatctt tttctggaac tgaggaaagc gggtgaaagg gaggagctgaccccggaggg
37261 gtggggcaga gaccctgtgt actttttggc ctgctttgat tcaggctgctgtgtggacac
37321 agccttgact ctctgggggc ctaagaaagg cagagctggc agccaggtccccagagagag
37381 agcctcacct accccctcac ctcatcccca ggtgaccatg ctccctgccaaacaggcaga
37441 actgacccgg cggagccaag cagagccccc tcatccttgg agtcctgagaagagacctga
37501 gggagatcgg cagctccagg ggtccccgct gccccccagg acatcagccaggacccctga
37561 gagggagctg cggacacaga gacctctgga gagtggccaa gcaggcccaagacagcctct
37621 gggggtgtgg cagagtcagg aggaaccgcc agggtcccag ggccctcatagacacctaga
37681 aaggagctgg agcagccagg agggaggcct gggccctggg ggctggtggggatgtggaga
37741 gcccagcctg ggggcagcca aagccccgga gggagcatgg gggggcacttccagggagta
37801 caaggagagc tgggggcagc cagaggcctg ggaggagaag cccactcatgagctccccag
37861 agaactagga aagagaagcc cactcacgag cccccctgag aactggggaggccccgcaga
37921 gtcctcacaa tcctggcact ctgggacacc cactgctgtg ggctggggggcagagggagc
37981 gtgtccatac ccgcgtggct ctgagaggcg acccgagctt gactggagggatctgcttgg
38041 ccttctccgg gcaccaggag agggggtctg ggcccgtgtc cccagcctggactgggaggg
38101 cctcttggag ctcctgcagg ccaggctgcc ccgcaaggac ccagctggacacagggatga
38161 cctggccagg gctttagggc cagagctggg tcccccaggc acaaacgatgtccctgagca
38221 ggagtcacac agccagccag aaggctgggc cgaggccacc ccagtcaatggacacagccc
38281 cgcactgcag tcccagagcc cggtccagct gcccagccct gcctgcacctccacccagtg
38341 gccaaagatc aaagtgacaa gaggaccagc gaccgcaact ctggcaggcctggagcagac
38401 gggccccctg gggagcagga gcactgcgaa gggccccagc ttgccagagctgcaggtaag
38461 gaggtttcca ccctcccaag ggtagccaga aagtcagccc cactcagccaagtctccttg
38521 gaaaagcctc cccttggagt agcctaagct cctgcatccc cctccaggctcagacctcag
38581 cctccctgct gaccacaacc catcccgatc accaaactgg cccaacaatgatgatgagca
38641 acacagtttt aagcgtttat gggccaagcc ctgatctgaa tgtttgacgtgtgcttttcc
38701 catttagtct ccttagcaac caggtgagaa atacactatt tacagataaggaaactgatg
38761 cgcagggtga agccacttgc tggtggggca tgggcaaaac ccaggtctgctcagtgcaga
38821 ccacactgag gcctcaagca agatgctctg gccagggcct attcccctcctggctccacc
38881 atacctggtt tatgttgtgt ctggtggcac acacctgacc ccacctgggactgtagccag
38941 tgtgggcatg ccccttcccc tggtggtact caggtacctg agtccaggacagcctcgctt
39001 accctctctg gcccctacag ctcctctcag acacagagaa gagggtgcatcaatgctcac
39061 tgggttcagc tagctgccaa gacaggctgc ttaaatgagg gtcgtgtgcaaagtgggccc
39121 agcgccgggc acacagtagg tgctcgccct tcccctgctt cactggtgctttggtgctgc
39181 cttgaagccc agaacattct tcatctgaag atggtgggca gggagggtcttggaggccag
39241 aatcctgcac cctggcaata gctcattggg aggacggcat gtggttttgaacaccagcct
39301 ctctctctct ctgtaagatg gaccaaccac ttctctgacg ggcagcgctggggtgccgtg
39361 ggggttcctg cttgtttctc caaagcctcc tcatctccta gatgcaaagtccaacgccac
39421 ctgccccagg atgagcaggg cttccaggca tcagggtgca ccccgtgctgggcccagggc
39481 cttgccatat gtgcctcaag tggataggag gcagctgcca cttgacagatggggaaactg
39541 aggctcagac tccttaggca tttgctgggg gtcacacatg cataggtcgtgagaaatgag
39601 atcaaagcat ccactccaaa gtttgtgctt ttatttttat ttatttatttacttattgag
39661 acggagtttc gctcttgttg cccagactgg agtgcaattg cacaatctcagctcactgca
39721 acctccgccc cccaggttca agctattctc ctgcctcagc ctcccgagtagctgggatta
39781 caggcatgtg ccaccatgcc cggctaattt tgtgttttta gtagagatggggtttctcca
39841 tgttggtcag gctggtcttg gactcctgac ttcaggtgat gcatccaccttggcctccca
39901 aagtgccggg attacaggtg cgagccacca tgcccggcct aagtctgtgcttttagccac
39961 cacgtcacaa agctcctgag cccatgggag gactggagaa ccctctcccctgtatttccc
40021 tgtggctttg atgagttgac cctccaatca actcaatgcg tggacatcagagaagcaggg
40081 ataagtcagc tcgtcctgcc ctcagattgc tgtcaggctt gttaggaaggcacacagaca
40141 gctcaaggag gacacggtgc tgtgtcccgg ggcatgctgg gtgccacaggccggccaggt
40201 caagaaggaa gttagaaaga ttcttcagtt tcatggtgaa gctcagggttctcaggaggc
40261 taggagatgg tggctgggaa gggatgggag caccatgtac tgaaaggaatttcacagatg
40321 acaaaacgag taaccaccag gtcctgctgg ggctccagct gctcctctctatgaaaatcc
40381 ttggcttggc acagctgggt gcagtggctc acatctgtaa tcccagcactttgggaggct
40441 gaggcaggca aatcacgagc tcaggagatc gacaccagcc tggctaacacggtggaaccc
40501 cgtctctact aaaaatacaa aaaattagcc gggcgtggtg gcgggtgcctgtagtcccag
40561 ctacttggga ggctaagaca ggagaatggt gtgaacccgg gaggtggaagttgcagtgag
40621 ccgagatcac gccactgcac tccagcctgg gtgacagagc gagactccatctcaaaaaaa
40681 aaaaaaaaaa aaatccttgg catggcactc aaggccggct tcccttccttccactccgga
40741 tttgcctcat tggtgctgag ctggctgcag ggcctgtgag cacatatccctgcctttgca
40801 catgctcttc cctgttcagc caccaaacgc ctgttcattg tcgaagtcttaggtcaggct
40861 ccctgtcctg agaagccttc cctgaacagt cactcctagt aatggtccccttctgggctt
40921 ggcagttttg cttccatttg tccatgcaac atccatctaa tagggttgtcatttccccat
40981 aagctccaca caggcaggat ctctacctgc tttatctctg taactctagctctggcccag
41041 ggcctgacat aaaggagggg acagctcagt ggatgcatgc aagatggaggacacaggggt
41101 cagtgggtga acaatgaatg aatggagggt gaatgtgtga atggatgatggatcaatgat
41161 gcatgttgaa tgaataatag acatcttttg gatggatgac agatgggtgatgatggatgg
41221 atagctgggt gatgaatata tggtggtggt ggatatatga tggatgttgcttaggtgatg
41281 gatggatgaa ctttgggtgg aatatgaatg gatagatgtg gcatgggtggatgaatgtca
41341 gatgatagat gttggagata tgggtagatg gatgatggat ggagagagggatatgtaggt
41401 attgggtaaa tggatatgtg atggatcaat ggagggtaga tacatgaatgggtgatagac
41461 aatggatgat gggtacatga gagggtgagt catgtgatag acactggatggttggatgga
41521 tacatggatc tactgatgct ggacgttaga tgggtgttgc atggacagatgatagaatgg
41581 atggatgagg tggacagatg catgcatcct ggagaataag ttgggctaagctgtgttctt
41641 tttttaatct ccagttccaa ccagaggagc ctgaggagtc agaaccaagcagaggccaag
41701 accccctgac tgaccagaag caggcagact cggtagctgg gtcatgggtgtgggtacata
41761 cggtggggaa gggaggggga agcaggttgg agatgggctt cattcctcagaagagcccta
41821 gaatcaacca gaccaaagtt ggcattgcca tggggtcatc tatgtgcatggtggggcctt
41881 aagaagaggg gctctgcagg agccaccttc tggcttgggg acctgggtaggtgggcgatc
41941 ctggggtcag aaccctaggc catgcttctc atttgctggg actgaaaaggtcaatgtctt
42001 tccctgcgca aatgatggtt tggccccagt ggtctctgtg ggaagagatccttccggttt
42061 gaaagggcca ggccaggctg aaagagcagg gcttccacga gcaggagccagagagctgag
42121 gatgtaccca gtcagccagg cctggagggt ctccagggtc ctggaggcgggagagatatg
42181 tgcgggggtg ggacccacgg atgctgctct gaggcctggc tgcagctggtgagcacaact
42241 ctgcccgccc ctccccgtga cctaccaaac agactgttct cgtcaccctcagcctccaga
42301 gaggtgagat cagagttgag ggccgtgggg cagtgggagg tgggggaggaggagacagac
42361 tgtttggggc tgtgttttcc ggtcctgctc ttcctcccgt tgcctcctgaagccaggggt
42421 ggcagggagc gtccattggg cagcatagcg ccccccaagt agggccctgccgtgagtcaa
42481 agctggggga attctgccca aaccctcact gtgcagatga ggaaatggaggcaggggagt
42541 cgtcccaggt tatacagtca gtggctagct ggactgggac tagaacccagggcccaggaa
42601 ccacccagcg ctctctctgc acctccacct ggcacccatg ctgcccccgtccctgccccg
42661 atttcttgcg tggcttcgaa cggcagtgct gtaacttcga gcagtccagtcttcccatct
42721 gtggaatggg cggggacagg ggacactggt cgctaaaggc gctgccagccctcccaggga
42781 ctctgacaac tttgctcttc ctctttctgg gttatttctt catatcctggagccagagta
42841 gtgaacgagg cggaaacagc aatgccgggg tgcccctcta gtctccatgaaacgggcccg
42901 gcccatcaac gtggaaaata tctcaaccta cccccacccc taggcagccttgactggtca
42961 gaactgataa ccacctcatt catgcattct ttcacacaca cttagtgagcaccttctgta
43021 tacccaggtg tgggtcacag gtgagtcgga gcgccatcaa agagttcagtctagtgagat
43081 ggttgcatgc ctgtggtcag gactgtgatg gggaatgtgg tagcagggtcgggggcaccc
43141 ctacccccaa agccctcctg gacctgtgct ttgatgcttc aagttccacttccaaagagt
43201 ctgcagattc cagagcgagg accctgggct ctctcctacc ttcccagtaacccatgtgtg
43261 gctttggaca agtgcctctg cttcacaggg gccttggttt ccccaacgaggatgactcca
43321 aagagggagc atttgggggc tctgctagga atgtgtgtag aagtccacaactcattccct
43381 ttgcttaagc tggggtcaca aacctaacgc cctgaaggcc aggcaggtaacaatggtgag
43441 aaggtggggg ggcaccgagg gcacttgtgt gactcctcgg ttccagatagctgttgccat
43501 ggggaagacg ggcccagagt ttccacatct ttcgatattt caagaaacactggagatatg
43561 tatttatatg tgaaatctct aacctaatgt gaaatactct gaaaacactatgtgggcaga
43621 aacatacctg tggtctgcac cccctccagc tggcgcccgt ggtttgactttagggtgatg
43681 acgtgcacac cttcaaaggt gctgagccct gggagccttg tcagtccaacacgatgtagt
43741 gtgaacaagt taaccagctc gtctcggcag ttctgggagg agagaaagatgggaaccctg
43801 gggctccatg gtggggggca ccacagaatg ggcaggggag gctgtagccaggggtgcccc
43861 catcctgcca aagggacctg gggccaacac tggaccctgt ttgacaggcagacaagaggc
43921 cagcagaggg caaggctggg agcccgctca agggccgact ggtgacctcatggcggatgc
43981 ccggggaccg gcccacgctg ttcaatccgt tcctgctgtc tctgggggtcctcaggtggc
44041 gaagggtagg ctggctccag tggggactgg aggggtgagg gtggatagagacggggatgg
44101 gagggaggag ggggctgtta agcaaaggag agagagtggg ggctgaggaggaggcaccta
44161 gggccgtcgc atgacaggag aggtgggagc agagctctta agctcatcctggtctcagca
44221 agcgagtggg tttcccactt ccggggcagg cttgggggct gctttcagcttttggagtga
44281 ggggtgatgg aataatctac acagctgaaa gcttccaatc agcagcctctcgccagccct
44341 gggccaacgg ggagccaggt atgggggaag ggaaggcgag cttataagtggctctgggat
44401 tgcaaagtgt gtctcagacc tgggcctgag ccagtttcac aaacatctggcgttacgtaa
44461 cccatcccct gcccagagag gcctggaaac actcaagcct ctggctgggttttccacaag
44521 ggcaggcagc tgagacccgc tccctcccac ccgcttcaca gcaggacagaaggggcctgg
44581 ccatctccag cagccacagg ctggctcatg gggtctcttc tctctttgagaggctgactc
44641 tcttactcac cgctgttggc tctgagtcca gcactaggct gggcacctcagagacagtgt
44701 gcccatttta cagatgaagg gactgaggcc cagggaggtg agctgacttgcctgaggtcg
44761 cacagcttgg ggtataaagg agctgatttt cctcattctc agatgagagaagggttgtag
44821 ccaaacttac tgagcctcgg ttgccacatc tgtctattag gaaaaagtctgtggagactc
44881 agggctgcag agagggctca gggagatcag gatgcatgga ggttgcggggctgttgtcga
44941 aacactaact ttcccatcca cttcagaatt tccttttttt aaaaaattaagacggagtct
45001 cgctctatcg cccaggctgg agtgcagtgg caccatctct actcactgcaacctctgcct
45061 cccgggtcca agtgattctc ctgcctcagc ctccagagta gctggaattataggcgtgcg
45121 ccactgcacc cggctaattt tttgtatttt tagtacagac agggtttcaccatgttggcc
45181 aggctggtct tgaactcccg acctcaggta atccgcccac cttgacctccaaagtgctag
45241 gattattggt gtgagccacc acgccaggcg tttttttttt tttttttttaaattaagata
45301 gagtctcgtt ctacccccag actggagtgc agtggcacca tctcggctcactgcaacctc
45361 tgcctcccag gttcaagcga ttctgccatc tcagcctccc gagtatgtggtactacaggc
45421 gtgtgccacc acacctggct aatttttata tttttagtag agatggggtttcaccacgtt
45481 ggccaggctg gtttccaact cctgacttca agtgatccgc ccgccctggcctcccaaagt
45541 gctgggatta caggcgtgag tcacccagct gagcccagaa tttcctttcgctgctctttg
45601 tggttaaggc accgagggtg agcaggcaag catggttatc tgagtagtgtggtaccttta
45661 agccatgggc aggaattacc ttgtctaact aaaggtcacc aacacacagcacgtctggca
45721 ggagggggca ggtaagtcct tggtagagcg aaggaggagc gaagcagggaaagcactctg
45781 gggtaatgat gctggctaac cagcacttat tgtatgccta ctacatgcccagctctgtgt
45841 tcactgcatg gcgccaccta attgcatttg atccacactc ccaggtgcagttagacgcct
45901 actgtccatt ttacagatga tgaagtgaag ctcagagagg gagggtcacttgctccaggt
45961 cacacaggga gcaaggggca gaactgagat tcagaccctg ctctggctgacctcagagcc
46021 cagtgcttcc aacacgcccc ctacaccact gccttcacat cctgatctctctgagccctc
46081 ctgcagctct gggagtcccc acagattttc cccattagaa agatgcggcaaccgaggctt
46141 ggtgaggttg gctacagtgg ttctctcatg tgggagtgag ggaaatgaagagctagggat
46201 ggaactgcca gcagggcctc ccagttacac agagcagatt taaacttctcttgggctgaa
46261 gcagtgaaat tagcccaagg ccaagagcca gaaagcctgg agtcgagttctggcttggca
46321 cctaacttgt gtgcccttct ctgagcctta ccttattatt ctcagtagagtaacggtttg
46381 agactggata acctcgaagt ttggtagctc tggtctttgc cagtttaataactcacccct
46441 gggtccctga ggctgtgctg tctctgacct gccaggatga gttgtggtttcttcattggt
46501 gcattcattc attcgagccg tgcttacgga ggatgtgctg tgggcttaggccctaggctg
46561 gtttccaaga tgtagacaaa aaacattcca gccctggcca ctggagcccagttaggtaag
46621 gacactgaca tgtaactgat gagaacagtg tggtcaccac tttagtggggaaaggtacag
46681 atgtagggag cactgggcca gcagttccta agtctgctgg ggacactttggcttcctttg
46741 gtctgagact tcaaggaaga aattttccag gccaacaagc attgggagggggaaggggag
46801 aaagagagag agaatgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtgtgtgtgtgct
46861 gggtgtgtgt gagtgtgtgc tgggtgtgtg tgtgtgtgtg tgctggggtacagaagacag
46921 gaagagaagt gttccaggca cagcagagaa ccatcagggg gtagaaggacctgtcttatc
46981 ctgggaattc ctagtagtcc agtgctgtgt atcttttttt ttttttttttttctgagatg
47041 gagtctcgct ctgttgccta ggctggagtg gaatgcagtg gtgtgatcttcactcaccgc
47101 aacctacgcc tcccaggttc cagcgattct cctgcctcag cctcccaagtagctgggatc
47161 acagccatgt gccaccacgc ccggctaatt ttttgtattt ttaccagagacggggtttca
47221 ccatgttggc cagcctagtc tcgaactcct gacctcaggt gatccacccgcctcggcctc
47281 ctaaagtgct gagattacag gcataaacca ccgcgcccag cctccagtgctgtgcatctc
47341 tttatttact tattgtattt tgcaaaattg accaaagtat gtgtctctccagcctgtcaa
47401 atgagaatct ggaaggccag gatgacaggc aggagccagg ttgtgatggttcctgactgc
47461 ctagaagagg aatgtagcac tgatctgtca gcattggtga tgtgtggaagaactttgagc
47521 agggaagtgg tctggtcact gtgttgcggg tactaggagg agtcgcaggggccagaaaag
47581 cctggaggag gctggtgctg ttaggtgccc agggcactgg accaggaccctggtggtagg
47641 tgaggtctcc tgcgtgttca ttcactctcc caaggactga ctgcctgagtgaggtgcaag
47701 ggtagggtga gaaaactcag cccggggtgc cagaaggcca gtttctagagttagatggac
47761 ttaaccttgg cctcattcct catggtggag agactcctgg cagcaaatgctgggaaagaa
47821 cttcagctcc ctgggcctcc atttctttat ctgcaaaatg ggaacagtaattataaaagc
47881 aataattttt ttttttgaga gggagtctcg ctccgtctcc caaggtggagtgcagtggca
47941 caatctctgc tcactgtaac ctctgcctcc cgggttcaag cgattctcctgcctcagcct
48001 tttacatagc tggattacag gcgcctgaca ccacgcccgg ctaatttttgtatttttagt
48061 agagacgggg tttcaccatg ttggccagtc tgctcttgaa ctcctgatctcaatgatcca
48121 cccacctcag cctcccaaag tgttgggatt acagacctga accaccgcgcccggcaaggg
48181 caataatttt tgaaccccaa atcaagatga cagaataatt gaaatgccaattattccaag
48241 cttccctgcc tccttgccta aggatagcta atgagggata aagaggttgtcctaggtgcc
48301 ttacttgaat taacacttaa tccttccagc aacctcatga ggtaacagcattaccccatt
48361 ttacagagag tgaaattgag caccgagagg tgccttgctt aaggtaacactaggctggaa
48421 tccccgtgcc acacgaactt cctagtgcat ttagcaacca attccaccacggtccctact
48481 cacctgcagg aaaagagcat ctaacaaacg gcccagcgtt ctgggaacctgagcaacggg
48541 tgcacgccca cacctgaaaa accccaaacc aaaaaagacc catttgtgaggagtgggcat
48601 ttgggagaga ccctgccatc caagaactca ctttgtgtcc agcttactcgctaggaattc
48661 cgcctcttcc tgtgtgacct cgggcaaatc ggctcacccc tctgagcctccgttttctca
48721 ttagcaaaat aagacctccc tcccaagtct gtggtgagga cgaaaatcgactcttggcga
48781 gtgggacccg ctgagtcgtt agtactgggt gctttgcccc ggtccccgccaaatcacggc
48841 gccgagccct agcggaccca tcgctccggg gccgggtcgg gaagcgcagcctgggcgagt
48901 cgtgcccacg cccggccgcc cgcatcctcc gcccccgcgc cattgccggagtcacctgca
48961 ccctgggccc ttccttcctc ccagcgcgcc cgcggcccgg gcccgcccgccctccggccg
49021 ccaccgccct cccttccctg cggccccatc cgcccacccc gccgtcccgccgtcccgccg
49081 ccccgccgcc ctagcgcgcc cgtcccgttg cggcaggtcc cgcccccggcccgtctcgcg
49141 cttccattgg cccgccgcgg cccccgccgc tgtttgtctc ggcttccccgccacccattg
49201 gcccgctcgg gtcctcccag gaagtttgaa aaaaaaaaaa aaaaagttttatgggcggat
49261 ggaaggggcc ggggcagcgt cggggaaagg aagggccgga ggcgcggcggcgggcggccg
49321 agaggggcgg cggcggcggc ggcggcgggg ttcccgcgcc gcggagcccggcccgagagc
49381 cgcgtccacg ttcctgcctc ctgctcccgc cgccctgggg cgccgccatgacggtgagtg
49441 ccccagtcag ccgcccgcgc ccgaggccgg gagaagggcg acgacccgaggcagagccca
49501 gcctctcccc tccggggcag ccccctcctc atttcccgaa ggcgagaggagggctgggcc
49561 ggaagacggg gccacctccg aagcgctttc ggccagaccg gcctcacccttcccgcaggc
49621 tcctcctcgc cttccctcgc ccactcgccc ccgggagccc aggcgaccctgaggggacgg
49681 aacgacccgt ctcgggcgcc ccctcctcac acttgcggca ccagtcacgggtggattcgg
49741 ggcgaccctt tcccacctcc cctccagccc cctagacgaa gacccgattccccaaggcgg
49801 ccaggggccc cagggaggag cggaggtggg cctgggctgg ggaggggcgctcgtgggtgc
49861 ggatgggtcg cgctgacccg ggcctgggca agccagccct ccgtgtggccgctggcccga
49921 ggtcgggtgg gcgagaagtg gccggaccgc cccacccaca gcccgggaggcagtcccggg
49981 acgtctgaag cagcgggata ccacgtcttc ctgggcttgc actttgcagcggtcctgggg
50041 ccttgggaca agcctgcgag tctgagtagg gggcatgatg gcaggggtttgcctttctca
50101 tgggggtgag ctgtacccaa gccccatcaa ttacctgtgc catagttagcatattgagcc
50161 tcacagctgg gttcgctgga ctccccactt cacagccaga taaactgaggcttggggagg
50221 ggcgctggtg agttgcccga ggtcacccca agtataagag aaggagtagctcctttccct
50281 gtccttctgg cccactgacc gtgatgttcg ggaagggagg ggtggggctgcttttggttt
50341 ctggctagtg cttcagggag gctctgacag cccagtggcc ctcctgggggaggatgagca
50401 gggtgtgtgt gtgcacaggc ggcagtaggc ctctttcagg ggagtggagaccctgcggag
50461 gagtgggtgg gctgctgggg gcgggctggg ctgctggggg gcgtggcacgcctagcccct
50521 gccctgtgag tgtgatggcc tggacttcct cggcgtcctc ctggacatcctgccacctcc
50581 ctgctggccc ttcctgtcgt cagcagcctc cccttttctg tcaggagcagaagggatgtg
50641 gggggaggag ctgagtcagt gtcctggggc caggaggaga gaagttgccttgcccaccgg
50701 gtgcctgccc ggccctcagc cgggtgcttt cacgttacca gatttgatccttgaaggttg
50761 gtagtaacat cttaatcaaa cagatgagga aaccaaggtg tggcgaggtgaagtgtcatg
50821 ccccaggtaa ctcagtgagt cccaggctaa gccagaattt gtatccaggtccgttccagc
50881 tttctttcac agttgcctgt cctgggggca gcacgtgctg agcaagggtaaggctgccgg
50941 aagcagcgtg tggggtgctt ggaagatgga cagcacatcc ctgctggtggcagcagcctt
51001 cctgagggag gtgtcctcct gtgattatag ggccttgtca ggtggagatggactagcgag
51061 gagacagcag tgtggacaga aacgggtggt catgtttgag aagtagcaagagcgtaggga
51121 aggggtctgg ggaggagggc ctcactgcta gggcttggac aggggcaatagagagccatg
51181 aaagctttta gagcagagag gaggctatga tcaccattaa tagtgttcattgagttcatc
51241 ctggctgcca tgcagacctc agcctgctct cagctggtgc tcctcctgtacccacctcac
51301 accctcctcc cctggccccc gtgccctgaa tcagggatcc atacagagcaagtggcacag
51361 gtgtgtgagt gtgtgaggct ccggggcttc agggagttgg gattctcttccacccctttt
51421 gcctttgcct gggtgcagct ttgctcccgg atcagccttc cccctcgcctgctgggcatc
51481 aaattatatt tggtcccttg tttactgtct ctttcctaca gtccaccagggcaggggcca
51541 cagctcttgg tcacagctaa tttcctggcc tagaacagtg cctgataactttaaaaaaaa
51601 attttttttt ctgcaaacac tccctgagcc cctatctgtg ctgggtcctggcaggtaaac
51661 agtgtatgtc cctgactgtg agttgcatct aatctagcct gtgaaggataagtaaagggc
51721 ctcaagatag tcacggatgc aacagaggcc tctgagaggg gccatgggagggcaggacgg
51781 gggcggctgg tggtgcggtg agtggcatga actgtgaagg gacctcagaggtggccatta
51841 agctgggtct taaggcctga gtagccgctt gcctagtcat cggaggaggaggaagcatag
51901 tgtttcaggc caaggacatg gcacatatga agggcccgga gtcctggtgtgttgtgatcg
51961 gcaaggaata tgcagtggta taaacagggg cccctcagca aggggaggccaggctggaag
52021 agtgtgatga ggcttccctg ccatcctgag gcagctggac tttgttttaaagccacctgg
52081 agaccgggtg tagtggctta tgtgtgcctg taatcccagc attttgggaggctgaggtgg
52141 atggatcact tgaggtcagg agttcgagac cagcctggcc agcatggtgaaatcccatct
52201 ctactaaaaa taaaaaaatt tgctggacat ggtggtgggt gcttgtaatctcaggtattt
52261 gggaggctga ggcaggagaa acgcttcaac ccgggaggtg gaggttgcagtaagccgaga
52321 tggcgccatt gcactccagc ctgggcagca gagactctgt ctcaaaaataaagcaagcca
52381 cctggagccg tccctggaac tgttaagcaa gcctgggata ccaagcctttttgagtgagt
52441 cccgccagcc cgagggtgtg tagaggggtt gtgtgcctgg ccaggtaggaggcggggctg
52501 tgagaacctg ccagtactcc cgaaaggcgg aaggagaaac tgagcttctagcaggtgaag
52561 aagaggtagc tgggcctgaa gagccctgta tgaaggggca tcgtgggagatttagatgat
52621 cggacctttt gaccctgggg acaggtttcc ctgccagttt aaaaactcacattggttggc
52681 cgggcacatt ggctcacacc tataatccca gcatttttgg aggccgaggtgagcggatca
52741 cttgagctca ggagtttgaa accaacctgg gaaacatagg gagaccccatctctacaaaa
52801 aaaaaaaaaa aaaaaaaatt agctgagcat ggtggagtgc ttatgtcgtcccggctactt
52861 ggaagctgag gtggaaggat cgcttgagcc caggaggttg agtcagcagtaagctgtgat
52921 cacaccacca cactccagtc tgggcagcag agcagggccc tgtctcaacaaaacaaaact
52981 caaattggtg accttctatc cccaaggtca ctgtgtcatg gcgtgcctgacatggtatgt
53041 gatgtgtctg tactgggctc tggaggatca ctaggtttct ccttgtacagacacgttcag
53101 tcctgtcgga agctgcggga ggggaggacc gccccgtcat ttgccacatcaggcagccag
53161 gactcagaga ggggatgtga cttaggaagg tcacagtgac tccacttcccaggcagccct
53221 agaggttcca gcctgacagc ttgtcattcc tgccccaatc tcccagccctggcccaggga
53281 ctttcgcctg ggactgccca gtggtgccag ctctgtgggc ccaggaagcctggctcctcc
53341 gggctaggtg ggggtagggg agatggccca aaaagcacag aaatttagaccagggggtag
53401 atatttcctc agcaagtttt tcctgagcct tgctgtggtc aagccccctgcaaggccctg
53461 gggccacagg aggtcccaga ctgaggggaa gtggagccag gtgtggtcaccaatcttcat
53521 tcttagcttg ggatcgccct gggcagcctc cgtctcaggt ggaagacggggtgggcagaa
53581 tacagagcag cgggacaaac gcagccccag gggttctcgg ccgtgagcagagcctgtgtc
53641 tctcccttag acaggtatac agggaggggc tgggatgcca acctactgggtcccccgact
53701 gtggctgtgg aaggttctgg atcttcagct gtcccaagcc ccggttggtccacttcctat
53761 acctgagaag gggctccgtg ggtggagagt gggtcgggag aggtggccaggcagggtggc
53821 tgtggtttcc agctgccact gtcaccgccc actccactga gccatgccacccgttctctg
53881 caggcaacca gacaccttgg cctggtgagg cctcgatgta ggggctgataggtaggctca
53941 gagccatggc aaccggtggc cacctcctcc ctgccggcgc caggagcggagactgcagag
54001 ggaccgggac ttagatgaga gaggtctccc cagcaggaag ggagggtctggtggttggca
54061 cccactagat gagcatggtc agaaaaatat caggatgagc aacttctttatctaggcctg
54121 ggtgggggtg cctggcacag gtctccatgg gacatgctgc agctggtagcccccagaccc
54181 cggggctgtg cccccctggg cggcacccag aaggtagggc ttgccaggactgacccttcc
54241 caaagagatc taggcgggga ccagagggtt tctgacccca gcctgtgactggctccacct
54301 cccatagtct cctggagccg aggaaaggac aggactggcg ggcccatgggagggtccgtg
54361 gggcacttgg tcctcgtcag agggaggaac tggacagttc gcgcagtgctgctggtctgg
54421 actgccctct gagctctcag ggggtctcta tgcaggcaga gtcctcccagcccctctctc
54481 ccattcttgg gcgaggggtc ggctggagag aggcccctgg gacatctgggtgtgtgtgcc
54541 agccacccag cccaacttct tggctctctg agtgccacta tcaggaaaggggccagggct
54601 gcctcagtgg ctgggaggcc tgcttggact tgggggttac ctagggccttagccctcttg
54661 gctggcttcc caggagctcg gtcccacagg acttggggac agggtgggtgcagcacgctc
54721 ccctcaccag cccccattgg cttcctgctg gacccaactc acctccctcctcatctcccc
54781 acagcccgat ctgctcaact tcaagaaggg atggatgtcg atcttggacgagcctggaga
54841 ggtaagagga ctgaggccgg aggggaggaa gctggcttgt gctgctgctgggcccctggg
54901 cagcccagga gtgggggtgg ggctggggct ggtgtgagaa ccctgggggtggggctggga
54961 ggggtggagg ctgcccatta ggcttctgcc tcctggagca gtctgcagtgtgtaaaaggg
55021 atcacagcaa ggggccgtct agcccctcac acccagtgcc ccatcccttgatctcatcaa
55081 gagtctcttg gccctgccac ctcagtagga gcctgggtgg gagtcaagggtcttgggtgg
55141 aagggctcgt agaagctgtc tggcccgaga cacagattcc taaagcctggtctgaggggg
55201 gtggggctca gggcgcaggt gctggggttt cacccacctg gatccccactggttgagtca
55261 aagcctcctc tagtcctcag tggccacgtc tgtgacatgg gcataatggataatggtgat
55321 tctttctaga gtggataaca aggtcagaga gatcaagcac gtacaggtgccacaaagctc
55381 ctggcactta ctgtgggctc agctaaagac ccttcccttc ctctggcatatgtgtccttg
55441 gaaccagcag ggacagtggc tgtttcctca gctctgttct ttcggctgccaggctggctc
55501 cctgcccaca ctgcctgggc aggagcgtct ccccacccct gccctgcatgcgcctgctgc
55561 tctggtctgc gtgcagcctg catgccggag agggctttga gccagaggggatttcattgt
55621 gtttccggcc cacatgtttt attccctcca gcccacagcc ttccctacccgctgcctgcc
55681 cgctgtccct ggtggctgct ctctaggctc acacaaagcc cggcaccccgccagtgaccc
55741 cttcctggcc tccccaccca gggtccccgg agggcagagg gattacaggccccacccaga
55801 gctggccatt agtcatcctc tatcacaggg ttctggaatg tccgaactggaagggccctg
55861 ggaattcagc cagcccaacc ccttggtgca cagacaggag acgggcccatgagggtgttg
55921 gtctcttcca ggcctaggag cacctggggc agacccaggc tcagaactcagcgcacctga
55981 ggcccatgga gctccaccca gcttccatct cagacagtca taggctaggcctggaagagc
56041 taaagaaacc tcttggcata gaacccctgt cctactttac agagaggcaattgaggtctg
56101 cagcagcaac tccgtttact tagtgagagg aaaatgcttc taagaggcctggcctcccag
56161 aacaaaccca gcaacctggt tggtgtccat ccctatgcca agggccatgacagccatcca
56221 cacaagagag gatgggcgcc gctcgcctca ccagaaggtc taggcacttctttttttgtt
56281 ttttattttt gttttttttt ttctgaggca gagtttcact cttgttgcccaggctggagt
56341 gcagtggcgc aacctcggct cactgtgtct tccgcctccc gggttcaagcgattctcctg
56401 cctcagcctc ccgagtagcc gggattacag gcatgcgcca ccatgcccatctaatttttt
56461 tttgtatttt tagtagagac agggtttctc catgttggtc aggctggtctcgaactcctg
56521 acctcagatg atccaccctt ctcagcctcc caaagtgctg ggattataggcgcgagctac
56581 cgcgcccagc tatagggact tcttagtagc cctactttat ggttcagaagactgaagctc
56641 agaaaagtgg agacacttgc ctaaaggcac acagagagaa agggaactcttggatacaaa
56701 actccttttc tcagggaggc aatgtggaaa gaagcagaag gtatcgtcgttgcatgcccc
56761 ttgagaactt accatcttct tgaggagaga aaactaagta cttgaaacaaccaacagcac
56821 agacagggct tggtgatgtg agggaaccct gggagggctg gggaccgggtgatatgcact
56881 gaccctggca gtgggcgggc cgcgactggc attccagtgg agtgaccagaagcccagagg
56941 tgggctgggc ttggcatact atcaggctgt tctggcgccc ccacccctttcctacatgtc
57001 ctgccaatct aaccccagct ggagcagaga caggcactgc aggaaggcacccaatcacaa
57061 atcctaaact tacagcttag ggcgctctca cctgctgcgg atgtgggtagccagcctaca
57121 gttcaagaag cagaccgtgc atctgggcgc ggtggctcac gcctgtaatcccagcacttt
57181 gggaggccaa ggcaggtgaa tcacctgagg ccaggagttt gagaccagcctggctgacat
57241 gatgaaaccc tatctctact aaaaatacaa gaaattagct gagcatgatggcgggcgcct
57301 gtaatcccag ctactcggga ggctaagaca ggagaatcac ttgaactcaggaggaggggg
57361 aggttgcagt gagtggagat tgcaccattg cactccagcc tgggcaacaagagcaaaact
57421 cctccatctc aaaaaaaaaa aaaaaaaaag gcagcagatt gtggctggcactcactccta
57481 ctccagggct ccatccagtc ctacttccca ggggaccatt gtccctgaccatggtgatga
57541 tctgggggaa tatggaaaaa gacgtaacgt cctggccccg ctgagtccctgacttgctta
57601 cacaggtcat cacccctccc tgtctgcact gggtccgggg tgcctgaggagccttggcaa
57661 tcttaaaagg agctccaaga aggaaaggga gggtgtggtt acggaggggaaaccaatcca
57721 tttcacagat gctacccctg aggctcagag aggaaatgga ggggccaggtctcaaattgg
57781 cattttccgc ctccccaccc ctcctgtgtg cagcatagtg agtttggcagccacacagga
57841 cacctgtaca atcacacaca ctggctcttt cattccatcc tccttgcagcctccctcccc
57901 ctcgctcacc accacctcta cttcgcagtg gaagaaacat tggtttgtgctgacagattc
57961 aagtctcaaa tattacagag actccactgc tgaggaggtg aggccatgggtgtactgatg
58021 aacccccgga agggcctggg gtggcctggc tgggttcact ggggtgggtcacaccagggc
58081 ccacacggac catagtgggc cctcttgctc caggcagatg agctggatggtgagatcgac
58141 ctgcgttcct gcacggatgt cactgagtac gcggtgcagc gcaactatggcttccagatc
58201 cacgtgaggc tgtgtgcagc ttgggggctg gtggtgggca gcatggctggaggtccctgg
58261 gggaggtttt ggtgttgaac atggctcacc atggagactg gatcccttcactcatttacc
58321 cagaggccct atcttcagag ccagagctgt gatgccaaca cttagcatatctgggggaga
58381 cgctggagcc agcagggctc ttcccaggcc aatggaaggg aggttttgtaccccctgccc
58441 accccagact caagacctta gatgcatcct gggaaggaag ggccaccctccctggggtcc
58501 atagtgggga gggagtcatg cggctggcca tgtggcaacc tacccatgcggtggccttgc
58561 agaccaagga tgctgtctat accttgtcgg ccatgacctc aggcatccggcggaactgga
58621 tcgaggctct gagaaagacc gtacgtccaa cttcagcccc agatgtcaccaagtacgtac
58681 taagctggac tggggccttg agggaggcac ttacccttgc gtccccgagtgggtttctag
58741 gtactcacct gagggctgca cctttctggg ccctcgtttc tctgtcaacaacatgggaag
58801 agagtagtga gcattctcgg tatcatccag aagtacactg agggtttgaggtttgatctg
58861 tcttctcaaa tgtgatgggg cctcttctct ttggaggaga tgcctgtgagtcaaaagccc
58921 ctgccaggtg gctgttctgt ctctgtgtct gtgccgtggg ggccgtgtctaagcctgtgt
58981 taggaagggg tggttaggta gttcagcctt ggcgcccaca cctcccgggatggggagctc
59041 actccttctg gaggctgcca cgggcactgg ggcaggaggg ctgagttaccgagtggcaga
59101 gccccccaca gtttataccc agatgcccat ggcgggctgg gacttggagctgctgggcag
59161 cgggaacaga gtgtggtatt aaagggggct gggctgggtg tagtggctcacacctgtaat
59221 cccagcgatt tgggaggctg agatgggagg atcacttgag ctcaggagttcaagaccagc
59281 ctgggcaata tagtgagacc tcgtccctac aaaaaattta aaaatcagctggccgtggta
59341 gggtgcgcct gtcagctgag gtgggaggat cacctgagcc cggaggccgagtcccccaga
59401 ctggccacac cgcggctatt cagccttagg ccagaggctt tcctgtctaggtttcagagt
59461 ccccatctgt cacgttagca tgtcatgtct gtacatgtgc caggatgtgcccagagcact
59521 ttgtgaactc tgaagcactg tgcagttgga ctgttattta gcatctaggcccagctgctt
59581 taagaaagaa accccgggca cagtaacttc atcgagatag atgttcatgtctcccttcag
59641 aacagccccg aggtatgcag tcctggcctg gtggggctcg ctctgccgtttcaggggagc
59701 cacctgccac acccactcgg cagcctatag tcacatggct acaagtagctgtgggaatac
59761 tgcgagtgta gtttttggca gggtgaccac gtacccagct atgactgtggataaagagaa
59821 ttgccatagt tgttcagagt ctctgcaact tgtgttctgt gcaccccgaggtcccgcctt
59881 caccccatca gcagtgactg ggcatccccc ttgccactgt gagcctcgggaacctgggac
59941 attggtctcc tacatcacct cattgatcac catttgcaaa aagccccctgcctgctttcc
60001 acgttcgccc accctgtcct cacatccatc ctgtgagagg cgtcgctgtcccacattaca
60061 gatgaggtca ctgaagctca aagagggcaa agagaccagt gtggtggttcacgcctgtaa
60121 tcccagagct ttgggaggct gaggtgggag gagcacgtga gcccaggagttcgagaccaa
60181 cctgggcaat atattgagac cccatctcta tcaaaaattt aaaaaattagctgggcgtgg
60241 tggtgcatgt ctgtagtccc agctactcca gaggccgagg caggaggatcacttgagcta
60301 aggagtttaa ggctgcagtg aactatgatc acaccactct acttcagcctgggcagcaga
60361 gtgagaccct gtcccttgaa aaacaaaaac aagaacgggg gcgagggaagccgggcatcc
60421 tggtgggtcc ctgggctgtc aagaggtgga gctgggatgt tcctggggtctgttaaccag
60481 gaagctcagg tcgggctgct tccttccctg gggtctgtct ccagcccctggcacagggcc
60541 tggcacacag gtgtcgctcc aaaagtgctc attgtgggac tgcaggggtgaggacccacc
60601 tgacgtggct ctgctggtgc cctaggctct cggactctaa caaggagaacgcgctgcaca
60661 gctacagcac ccagaagggc cccctgaagg caggggagca gcgggcgggctctgaggtca
60721 tcagccgggg tggccctcgg aaggcggacg ggcagcgtca ggccttggactacgtggagc
60781 tctcgccgct gacccaggct tccccgcagc gggcccgcac cccagcccgcactcctgacc
60841 gcctggccaa gcaggaggag ctggagcggg acctggccca gcgctccgaggagcggcgca
60901 agtggtttga ggccacagac agcaggaccc cagaggtgcc tgctggtgaggggccgcgcc
60961 ggggcctggg tgcccccctg actgaggacc agcaaaaccg gcttagtgaggagatcgaga
61021 agaagtggca ggagctggag aagctgcccc tgcgggagaa taagcgggtgcccctcactg
61081 ccctgctcaa ccaaagccgc ggagagcgcc gagggccccc aagtgacggccacgaggcac
61141 tggagaagga ggtaggcacc acggctggct ctctaggagg ccccttgccccagcgcccct
61201 ccagtccctg cattcatgcc ctggcatttg tcttgcactc ctacagtgatggggagctca
61261 cccctgatct gctgtgagtg tgcaccccac actcctgcga actagaatcttcttccttag
61321 accttagtag tttggtttgg ttttgttttg ttttttccta gttctgcccttagcagccat
61381 agagaagaga agtgggaaga gaagggagag acctgccagg ctcacacctgtaatcctaac
61441 attttgggag gccaaggtgg gagggtccct tgaagccaag agtttgagaccagtctgtgc
61501 gacatggcaa aaccccatgt ctacaaaaaa atacaaaatt tagctgggcgtgctggtgca
61561 tacctggagc cccagctact tgagaggctg aggtgggagg atggctggagcccgggaggc
61621 agaggatgca gtgagccaag atcaagccac tgcactccag cagtctggcaatagagcccg
61681 actttgtctc agattaaaaa aaaaaaagaa gaagaagaag ggcgagaccgtttattgttc
61741 atcttctgcc cgtggcctcc ctgcctgcac tgactcgtgg aatcctcacagcggcctcta
61801 cccctagggt ggacttcagc agttttactg acgggaaaac tgaggctcaaagatgtttcc
61861 tctgtcacct ccatgatgtg taaacatctg tgaccacagt ttccttttcctatccctgtc
61921 tagccttctc tgggccaagg ctctcccagg tcattgacct ggccatccaggaaacagccc
61981 agcgtgtccc ctggctacat ctcactccag ggctgcttgc ccttctcaaaccctgaggca
62041 ttcctaagcc ttccagggac gctgggcttg tatccgtgtg gagctggaagcctgcgggct
62101 cctcactgcc ttccaccagc cctgccccag cttccaggtc ccactgaccacccttctccc
62161 tcgtaggttc aggctcttcg ggcccagctg gaggcgtggc gtctccaaggggaggctcct
62221 cagagtgcac tgagatccca ggaggatggc cacatccccc cgggctacatctcacaggta
62281 aggccggggg gctgtttttc agggggaggg ggcagatttc tgcttgccgtgttatcagga
62341 aacagctgag attttgggag cccttcctgt gtgtgctgga acctgtgtggggcatttgac
62401 atgcgtcatc tcatttactc tccccacagc tggtgggcgt gatcactgtgcccgttttac
62461 agacaaggcc actgagctct gagaggttat gtgacttgcc caaggtcaccccgcctgcag
62521 gtctcaaagg tgggatttga gcgagggtcc ggctgactgc agagcctgtgtgtgagtccc
62581 cgtgtgacac tctgcacttg gacccttgcc ccggggaagt ggggggctagtggccccgag
62641 agtcactccc tgaacacagg gaaatcctgc cgaggcccac tgggccaaggccccacacaa
62701 ggaggtctgc aggacagggg agcctccagt agccctcaga gaatgcaccgtccgcctagg
62761 acagcggttc tcaacggggt ccattttgtc ccccttgggg acatttggctgtgtctggga
62821 atacttctgg ttgtcacaac taggacaaac taactctcta gaaaaaacgtgtgtgtgtac
62881 acatatataa gtttattata aattttacca ataaaaacaa tgcttagtacacaatttaca
62941 aataaaaata tataatttta ttgtgaattc cgtacagcaa atggatttttctcagaatgc
63001 tttcagtgat tttttccata ctcttgtatc cacaactgat taacaaagggggttgttcta
63061 acgtgtgctg gttgacattt ttgtttatgg taatgagtaa gatgagaagacatttgtcga
63121 aactttactg gtccatgttg tcagctactt ctttgctaga tcggatagtagttttctatt
63181 gagaatattt gagaatattc tattaagaat atttttgcaa ttttttgttctatttacaat
63241 gtaatggtta tagatgtgag atacttctaa gtttaatctg cattattagcattttcttat
63301 cacttgctta agtctagaca atcaacaaaa caataaatca agccctgatgtgtaatgttt
63361 accaattctg cagtgtaaat actcccgctg tggccaatgc tgcattaccagcacaaagtc
63421 cctggacaga gagttgggaa gagatgtcac actattcact aggatttccaccatgcggat
63481 acagtagatg tgattggccc caagagcacg cataatacaa cacagtgaaatatttaggaa
63541 gtaataaatt tgagtatcta ttgccttgtc tttaacatag ttaatttaaagtatataaat
63601 ttaattgtta atggctgtgc ttaacaacta catcacagaa ttactaaaaatttgacaatc
63661 agctgtctgt agttatcaca ccattatcta aagtagaaaa gaaggggccaggcgcagtgg
63721 ctcacgcctg taatcccagc actttgggga ggccgaagtg ggcagatcacgaggtcagga
63781 gaacgagact aacctggcca acatggtgaa actccgtctc taataaaatacaaaaaatag
63841 ccgggcgtgg tggtgcgcac tgtagtccca gctacttggg aggctgaggcaggggaccca
63901 ctggaaccca ggaggcgcag gttgcagtga gccgagattg cgccacggcactccagcctg
63961 gcgacagagt aagactccat ctcaaaaaaa aaaaaaaaga aagaaaagaaaagaaggctg
64021 agatctaggc cctaggcagg aggagccttc taaaaatttc caaggggaggtcacgtcatg
64081 agggggctct caggaaggca ttggctgggg catgagaagg aaggctggttggtgcgtatt
64141 gtggatgcct ccagtgctga gctaatagtt agaagctctg gcctggtacggtggctaatg
64201 cctgtatctc agcactttgg gaggtgaggt gggtggatca cttgaggtcaaatgttcgag
64261 gccagtgtgg ccagagtggt gaaaccctgt ctctactaaa aaaaaaaaatacaaaactta
64321 gcagggcatg gtggtgggcg cctataatcc cagctactcc agtggctgaggcaggagaat
64381 cgcttgaacc cgggaggcag aggttgcagt gagctgagat cctgccactgcagcctgggt
64441 gacagtgaga ctctatctaa aaacagcaac aaaaaacaaa acaaacaaaaaaagagaagc
64501 tcattccaca gacttttgga ggtttggggt cagacagtga catcaggaaagtgatgttgg
64561 agtggagggg gcttgggaga gggccaggtg taaggcatta ggaaatggctgaaggagggt
64621 gaatgtcaag ggtctggagg gaggagaatt tgggactgga tgaccagatctacggaaggc
64681 agaggggcct ttgggggccc tgaggctggg gctgctgctc cagggaagcccggagaccgt
64741 cctggggcca agtagtggat ggagtttcca ctgatagagg agcaggcaggggaattgggg
64801 tgggacgcag agggtgaggc tgggggctta ccttgtcctg gggaggggcaggggaggagc
64861 cagtgttgtg ccctgtagcc tcccaccctg aggcagagaa gggagctgggggcccaacac
64921 cccagctgag gcaggtggga gggcctccga ggcccccagc cagggggcttctgcctgcgt
64981 gctctgctct aagaagctgc aggggctgct ttctgggtgg gtggggctgggacccattcg
65041 tacccaccta taatcagagt ggcttcatct tcctccattt tattttattttaattttttt
65101 agagatgagg tcttttactg tcacccaggc tacagtgcag tggcacagaggctcactgca
65161 gcctcgaact ctagggctca agcagtcttc ccacctcagc ctcctgagtaggaaccacag
65221 gctacaccac catgcctggc taattaaaaa aatttttttg tagagacaaggtctcactat
65281 gttccctggg ctggtcttga actcctgggc tcaagtgctt ctctcatgttggcctcccaa
65341 agtgctgggg gtacaagtgt gaccactgca ctggcccacc tttgtccgttttactcatag
65401 agccagcttt agatttcctt tagataaagg ctctgccact acaatgacgtttaaaaggca
65461 ctgctttggc ttctcagctt actggtggca aaactgaggc ccacagaagggtgtgacctt
65521 tgagctatag gcagacctgt gtctggagtt caggcggtct ggtccccaggtgccccattg
65581 ggtgcaccaa agtctgtcag tgtttggtcc cgttagggtg ggatgggcacggggagcagg
65641 tgggagggga gaagggaata actggggagc agagctgaag accaggcaggtggaggagtg
65701 accccagatg cggaaggcag cagagaagaa gagctgagtc atctgtatcgccctcaggca
65761 cgggaggagg cggatggaaa ttcggtggac ctggaggagt gacagctgggagggattccc
65821 cagctggtat ctcgggctga gtgggtgccc ttccttcagg ggttgggggcttgctgctgc
65881 acgacagctg tcgggtggtc tggggcttca cccactggac atctggtaaagagaaccttt
65941 ccccactatt gcagtgggga cagaggcatt tctttatcta ctttgatgtccatgtcaaag
66001 gtggcagcca ggatcaggac accttgggcc actcaggaag gtaggtgagagaggccctag
66061 gagcccctgt tcgtcagctg agtcccacct cctgatgtca gcccctgcacccctgagctg
66121 ctgggtctgc ctgcctggtc tggccctctt cagaagagca gtgcccacccccacattgct
66181 gggctcccca ctggtggatg ctggcgtacc gtctccctct gtgcacagggttcccgtgcc
66241 cagggagcct cgggggctgg tcctgtgagg cctgctttac ggatgccaagactgaagctc
66301 agagggggcg aggggtttgt tcaggttcac tccaaggcgc agccagggtgaagaccgcct
66361 ctgaggtcca aagtcatgtt ctgttgtcct aagccaggag acacatagagggcaggaaca
66421 gaagccaggg gacagacacc cctgtcgcca catgaagctc ttggccctcgctcctccatc
66481 aaatcgtccc caggtgtggc tgctggagag gcggggaggt ggcctttgcgtgggggagac
66541 agtccctcat ctggtcctct gtgccttagt ttcttccctg gctcttcttccccttccctt
66601 tttaatgacc ttaaacattt ttttaattat ataaaagaaa tgtttacattttcaaaaata
66661 atttaaacaa attgaaaggc tggaaatcaa caccctcaca ctccttctgctgccagctgc
66721 caccccaggg tcctgtcggt ggctgctgcc gcctgcctat cagtttctggtggcagctgt
66781 aacctgtaac cacagctacc taaataatgc acatgtatta cctcacgcttctgtaggcga
66841 gaagtctaac gcgagtcttg ccgcgctgca gccaaggcgt gggcaggactgtgttcctct
66901 gcaggcaccc gttgtatccc ttgcctgctc cagcttctgg tggccgtccgcgtcccttgg
66961 ctctcggccc cttccttcat cttcaaagcc tgcagagggg aagtcgagtccttctcctgc
67021 cacgtcactc tgaccatccc ttcctggtca cacctccctt gaactcttcgcttctgcccc
67081 cttcgtccac ttttaaggac ccttgtgatt acactgggct tgagggataatctgggataa
67141 tctcccgatt ttaaggtcag ctgattagca accttgattc cctctgcagcctgaattcct
67201 ctttgccatg taacatgatg tagtcacaga tcctgggagt aagatgtggacaactttgag
67261 gggctatcat tctgccccct acaatatcct ccctaccttt tctgtgttttctgtgttttc
67321 cattcactgg gacggacagg tctgcacgtt tgttcccgtg agtgagatcataccacgtgt
67381 atgtcagaag ccaactttca ccacctcatt ttgggatctt tttccacagcatccacacaa
67441 aaactctgtc tagcagctgc ctgtgtccca ttgtcaagct cgatcccatcatttattcaa
67501 gagttcccct gatagggatt tagattgttt ccagttttca tctgttaccaacctggctgt
67561 agggaatacc cttgttccaa aagtctctgt acacatacga ctttctgtgggatcatttct
67621 gggagtgaac ctactaggtc aaccagtggg gtcgcaaaat gtgatgatgccaccggacca
67681 cccccaacac acaccgttgt ggcggacact cccagcagtg ggtattattagtctgagata
67741 cttgcccatc ttgtctacta agcattattt tgtattacat catcagtttcagctcattta
67801 ctgagcacct gccacatgtc aggccctggc ctagaccctg gggactgcgccagtcagatg
67861 ttctcagtct tcagggaatt tatggtttgg cagaggtaga accttttgaggcaggggaga
67921 ggctgcccag agacagagct aggagagaca tttaaactgg gctgcaggtcagtaaattac
67981 ccagggaggt aaagttgcca aaaaaacatt ccaggccggg cacagtggctcatgcctgta
68041 atcccagcat tttgggaggc caaggccggc agatcacaag gtcagaagttcaagaccatc
68101 ctggctaaca cagtgaaacc ccatctctac taaaaataca aaaattagctgggcgtggtg
68161 gtgggcacct gtagtcccag ctactcacga ggctgaggca gaagaatcacttgaacccag
68221 aggtggaggt tgcagtgagc tgagattgct ccactgcact ccagcctgggtgacagaaca
68281 aaactctgtc tcaaaaacaa aaacaaaaac aaaaaaacca caaaattccaggcagtggga
68341 atagctaaag ctcagaggtg tgaacgtgct gcaaccgtaa ctgtgagattgcttggcaga
68401 gaaaggccag ggatgagaac gtaaaggtca gccatgggaa cggggacttgactctgtagg
68461 acgaggaatc cctggagggc ttgaggcagg agcgacaagg tgaggtttgtgaatgaggag
68521 ccgtggggtg ggggtgggag caggagcagg tgcagactgg aggtgctgggacccaggagg
68581 aggtggtgta cctgcccctg agccttctcc tctggaggct ggggaagggccgctgtccag
68641 aggaacgggg cagcctgtga caccctggcg tccggcccac aggaggcatgtgagcgcagc
68701 ctggcagaga tggagtcctc gcaccagcag gtgatggagg agctgcagcggcaccacgag
68761 cgggagctgc agcgcctgca gcaggagaag gagtggctcc tggctgaggagacggcagcc
68821 acggcctcag gtatggaccc tggggggggc acagtgggct gggctctgagcctctgtgct
68881 gaggttcctc ctagccaaac tggggaggat tttatcaaat aagatgtaggggtctcagtg
68941 ccacatttgg ggtaaagggt cagcaggtgt tagaagctcc aagaactggcctgtagccct
69001 acttaaaaag ggaaactgag gcagtaaaag ataccctccc cacccccaacaccaccacta
69061 ccataggtgg tgactcttcc tgctcagggg cctgcagcca ccatagagtctgcctaaagg
69121 cacatgctac ccacgtgcgt gggggagagg ctgatcagct gcatcccctgtcctcatagg
69181 agtgcctcct ccctgggcac atgggccaga ccctggggag agcaggggaaggtgtgagca
69241 ttgtccatgc cagctgtgtg ccaggcactg ggccccacat gtttcccacaggagcaccct
69301 tcatcctgga caattccctc ccctcctgcc accgcacacc tgctgtgtgcctggcacatt
69361 cctaggcatc actaggggtt tgcagaacaa tagaaatgct ggccaatgtcacatgatctg
69421 aagctcacaa cctgccagtg ctgtgccaag tgctcatgca ctcgaacccagccttggggc
69481 cagtgtgctc tgcatttcag gaagatcgcc tttgcagccg cgtgtgttagagaccccttc
69541 cccctcagca gagtctggac ttcgccctgt aatctggcac taaggtttctgctgtgaaat
69601 ggataaaaat cacacttaag tggaataata aagaccataa atagcctcatgtccgttcag
69661 ggtggggatt gccaccaaaa gatttaccag aggcccggtg cagtggctcatgcctgtaat
69721 cccagcactt tgggaggctg aggcgggcag atcacctgag gtcaggagttcgagactagc
69781 ctggccaaca tggtgaaacc ccatctctac taaaaataca aaaattagctgggcgtgatg
69841 gtgggcagct gcaatcccag ctactcagga ggctaaggca ggagaatctcttgaacccag
69901 gagacagagg ctgcagtgag ctgagattgc accactgcac tccagcctggatgacagagt
69961 aagactccat caaaaaaaaa aaaggccagg cactgtggct catgcctgtaatcccagcac
70021 tttgggaggc cgaggcaggt gcatcacgag gtcaggagtt caagaccagcctggccaaga
70081 tggtgaaacc ctgtctctac tatgaataca aaaattagcc atgcgcggtggcaggcgcgt
70141 gtaatcccag ctactcagga ggctgaggca ggagaatcgc ttgaaagtgggcggcaaagg
70201 ttgtagtgaa ccaagattgt gccactgcac tccagcctgg gtgacagagtgagactccgt
70261 ctcctgggtg acagagtgag actccgtctc ctgggtgaca gagtgagactctgtctcaaa
70321 aaaaaaaaga aagaaaaaaa ggagagaaac tttcaatgtt cagaagtttcggattttaga
70381 attgtgggta aaaccatggg tggccctgag tgggaaaaaa aaagcctcggtctcagtcct
70441 taggagctca caatctgaga ataaagccag caggagctaa tgttggggcatttactctga
70501 gccatgcttt gttctaaatt cttcacacac cttccaataa ccccatggaggaaaggtact
70561 gttgttatcg atccctgttt tccagataag ggatctgagg cacaaggggttaagtcacct
70621 gtgcaaagtc acatcggttt atgctgactg tggagcctga gctcttgaccacgaggctgg
70681 tcaaagcaga taggccttgt ttgagagccc tcagagtctg cagggggggtgtactaggtg
70741 gggtcctacc tggaaatcac tagaacagga ggtaccaatg gtcagaccctgagctgtctc
70801 cccagtaggg tccatccaac aggattatct tcccttaata gatgggctgagagaggttga
70861 gagcttaccc caagccactc agtttatgac acaacctggg ctactctagactcctggttc
70921 ggtgctcttt gcatagcact ccttggtcca agtccatagt acttgcatagtactatgtgg
70981 agtccacata gtactccacc agtacatgtg gcgtctcaga gctggtggcacttggtgctg
71041 ctgacccccc tccagtctct cttgtgcctc tctgccctgc ttccagccattgaagccatg
71101 aagaaggcct accaggaaga gctgagccga gagctgagca aaacacggagtctccagcag
71161 ggcccggatg gcctccggaa gcagcaccag taagatgatg ccggggcccaactgcccacc
71221 ctgatggtta tgggttgagg aactttgctg aggccccttg gcagcggacacatcagtttg
71281 cccctagctg agattcctgc tccagtctca tggatgcaag aaacagaagcagaaggtcct
71341 caggcagacc ccatgccagt cctcacagac agtccttcag gcagcttcttgtcttggctg
71401 gtcccagcct ccacccacct cttcacccct ttagtctccc ctggagctgggctgcagtgt
71461 cactgttgac cactaggcct ctccctgccc cagagcacag ttttggaatgttgaggtttc
71521 aggggcttta actttaaaga tgggcccctc cagccgggca cattggctcatgcctgtaat
71581 cccagcactt tgggaggctg ggatcaggag ttcgagacta gcctggccaacatggtgaaa
71641 ccccatctct actaaaaata caagctagct gaatgtggtg gcgggagcctgcaattctag
71701 ctacttggga ggctgaggca ggagaatcgc ttgaacccag gaggcagaggttgcagtgag
71761 ccaagattgt gccattgtat tccagcctgg gcaacaagag tgagagcaagactccatcta
71821 aaaaaaaaaa aaaagatggg ctcctccaag ccaccctcac ttagggtaaacacctgtagc
71881 ccagagaagc tgtcactggt tcacagcccc acagcaggct aaaggcaaacctagagaggg
71941 aaccccagag tcctgggatg ctttaagtct acctgactgg actccaggcttggcaggagc
72001 aagacaacct atgctctcct ctgctcctcc tctggggcag gtcagatgtggaggcactga
72061 agcgagagct gcaggtgcta tcggagcagt actcgcagaa gtgcctggagattggggcac
72121 tcatgcggca ggctgaggag cgcgagcaca cgctgcgccg ctgccagcaggagggccagg
72181 agctgctgcg ccacaaccag gtgggcctgg ccccaggttg gggggacacgggtgggtccc
72241 ggcacccctc ccctgaccac cgtgcctctc ccaggagctg catggccgcctgtcagagga
72301 gatagaccag ctgcgcggct tcattgcctc gcagggcatg ggcaatggctgcgggcgcag
72361 caacgagcgg agttcctgcg agctagaggt gagtgtcctc actagcaccaggcagcccag
72421 tggttctcgg ggcccggggc tatggggcac ccccgccata ggctgggtatcacctgtggc
72481 aggaaagcca agtctcccag tggctgggcc agcctgacta ggctagaacacctactgtgc
72541 atccagtagc cagcattctg ccctcccacc tgcattgtgt cacctacctgccgtgtacca
72601 tagcaaatca ctccactttt ctgagtccca gtagctcatc tgtaaaatggcaccagcacc
72661 ttccttactg ggaaatattg gggtaagaaa atatgtgtgt atgtgtgtgatgccagtatc
72721 actgtagtat tttctttctt tttctttctt tctttttttg agacagagtctctctctgtc
72781 acccaggctg gagtgtagtg acacgatctc agttcactgc aacctctgcctccctggttc
72841 aagcgattct cctgcctcag cctcccaagt agctaggatt acaggcctgcaccaccacac
72901 ccagctaatt ttttatattt ttggtagaga caagtttcac tatgttggccaggctggtct
72961 cgaactccgg acctcaagtg atctgcctac cttggcctca caaagtgctgggattacagc
73021 atgagccacc acacccggcc ttagtattta tttctttact ttttttttttttttgagaca
73081 gagttttgct gttgttgccc aggctacagt gcagtggcgc gatctcggctcaccacaacc
73141 tccgcctccc aggttaaaac gattctcctg gccgggcgcg gtggctcacgcctgtaatcc
73201 cagcactttg ggaggccgag gcgggcagat cacgaggtag gagatcaagaccatcctggc
73261 taacacagtg aaaccccgtc tctactaaaa atacaaaaaa attacccgggcgtggtggcg
73321 ggcgcggtgg cgggtgcctg tagtcccagc cactccggag gctgaggcaggagaatggca
73381 tgaacctggg aggcggagcg tgcagtgagc cgagatcgtg ccactgcactccagcctggg
73441 tgacagagcg agactccgtc tcaaaaaaaa aaaaaatatt aaaaaaaaaaagcgattatc
73501 ctgcctcagc ctcccaagta gctaggatta caggcatgtg ccacctcgcctggataattt
73561 tgtattttta gtagagacag ggtttttcca tgttggtcag gctcttctcgaactcccaac
73621 ctcaggtgat ccgcccactt cggcctctca aagtgttggg attacaggcgtgagccaccg
73681 tgcccagccg atattttatt tctctttttt tttttgagac ggagtcactctgtcacccag
73741 gctggagtgc agtggcacca tctcggctca ctgcaagctc cgcctctcgggttcatgcca
73801 ttctcctgcc tcagcctccc gagtagctgg gactacaggc acccgccaccacacctggct
73861 aattttttgt atttttagta gagacggggt ttcaccatgt tagccgggatggtcccaatc
73921 tcctgacctc gtgatccgcc cgcctctgcc tcccaaagtg ctgggattacaggcgtgagc
73981 caccgctcct ggccccaata ttttatttct tcaacaaaca cttaggtgaggctcactctg
74041 tacctagaaa ttctggaagc cctttttgtc tgttaactca tctaatcttcctgacagctc
74101 catacattag ctactatgac tgtccccatt tacagatgag gaaactgaggcacaggaagg
74161 tcaagtacct taccaaagct tttatagctg gactgggatt tgaaccaggcagtctggctc
74221 cagtctgagc ttttaagcct ccccagtcct ggctgaactt gtttcctccttggtcaagtc
74281 agcagcacct agccctcggg gttggggagg ggttaatgag gtgccttgtggagtggttca
74341 gcctgctcag gtttatgtag ggcttctttt catccatctc actcccgaggtgagagcctg
74401 gtgctgcatg agggctgcag cagacttgac cgtgagatat ccactcacacgggctggaca
74461 ggggtgagag taagggaagg caaagcaggg gaatcggaga gggcttcctggaggagtccg
74521 cctccaggat gtagagggtt tttgtgcaga taggggctgc attctaggggcctgaggcag
74581 agagaacccg ggctgcaggg cactatgggc cagggtagct ctggcttctggccctgggtc
74641 agtccagcac ctatatcccc aggtgctgct tcgcgtaaaa gaaaacgaactccagtacct
74701 aaagaaggag gtgcagtgcc tccgggacga gctccagatg atgcagaaggtaggtccttc
74761 cgctgggctg ggggccgtcg gggactctgg agccatctgg atgccatcctgtgagcacct
74821 gctctgtgcc aagccctcca ctcgcttcat ccttcctcag gctctcctgtgcttctccca
74881 tgtaggtgtc atcatcccca ttcactgaca gggaaactga gactaagaaaggggaagtga
74941 cttccccaag gctgtacttg gcttctgttt atttagcatt atttaatttattgattatta
75001 ttgagcacct actatatcct gggcactgtg ctaggtgctg ggaagacagatgtgaacaaa
75061 ataaccccaa atctctgctg tggggagctt gcactccagt gagaataaccacgttgctag
75121 gagttgggtg ggtcagggtt cagcccaggt ctgagtctgc agcccgcctggcccaccctt
75181 ggctgctatg tcactgcctg gtgcgctctg tcagtttggg gcaggaagtggacatgttgg
75241 tggctctgta agtgcacgtg agccagaccg tgtttaccgc acttgaagaacaggtggcgt
75301 gaactcacag gaagggcccg agcacccagc caggctgacc tggttctcatcccagccact
75361 cactgccctg cggtcttggt caaaatcttc tcccccgaaa caggatgaggatgacaatga
75421 cgcctgtgtc cctgggtggt accagggagg tgggaggggt aagcccagaacccacggcca
75481 tcttggggag ccacctggag ggatgaagcg aggtatctgc ggggaggtctggctgctggt
75541 gctgcccatg tgcccggttg gcagggctgg agggagagac ttcatgccctcatacctgcc
75601 tcctgccccc caggacaagc gcttcacctc gggaaagtac caggacgtctatgtggagct
75661 gagccacatc aagacacggt ctgagcggga gatcgagcag ctgaaggagcacctgcgtct
75721 tgccatggcc gccctccagg agaaggagtc gatgcgcaac agcctggctgagtagaggtg
75781 gatgccgagg cgtgtgccct gcagggtggg caggggctga ggctctcccacacccgggac
75841 tccctggacc accccagcca ggccacttcc ttcttctggc ctccaattcccgttctgtaa
75901 aaaggacaat gaaaccagca acacggggtt gttgcagaga tcccatcagacccgggccac
75961 aggctgcttc atcagcttaa gcctgttcct ccagagctgg gcggcacagtgcagagccac
76021 agcctactca gtgcaccccc cttcttgggg ctggaggcaa atgcagcgtgcacatccctg
76081 acccccacag tgaatctcca ctgagcttca cacacacaca tcgcacgctgaggccgggct
76141 tctatcccag ttagtcttaa cactccttct tgacttagca gggctcaaagtggttggttg
76201 gttggttggt tggttggttg gttggttggt tggttggttt tggttgctttgagaaaggtc
76261 ttactctgac acccaggctg gagtgcagtg gtgcaatcac ggctcactgcagcctcaacc
76321 tcctaggctc aagggatcct cccacctcag ccttctgagt agctgggaccacaggccctc
76381 accaccatgc ccagataatt tttgcacttt ttgtataggt ggggtttcgccgtgatttcc
76441 caggctggtc tcgaactcct gggctcaagc aatacacctg cctcagcctcccaaaattct
76501 gagattacag gtgtgagccg ctgcacctgg ccaaagtgtt cttatttttgctttttcaac
76561 gccacatcta cctggagcat cctctttctg ataagtcctc atggacttcctatggcatgc
76621 aggagaggcc accctatggc tgagctgctt gggaaggagc caggaagagcggatctggct
76681 gtaccttagg ggctgagagg tggtggaagg acccactcag cacccttgcttggccttggg
76741 gtggcctcgc agcccctcag cccaggcctc agccctgccg caccttgtctttcaggtccc
76801 gcccagctgc agaccctcca ggctggagga ccagccgccc tccttccctcctggatggaa
76861 gtaaaaagcc aagctttctc cccaccctct gtgggccaca cgtgcacttgcacccaccac
76921 acacacacac acacacacac acacacacac agacacacag acacatacgcacacacgtgc
76981 acacatgtac acacggatac acacacacac acacacactg catatctgagcgcgcccctc
77041 gcactgggtc tcaccttgca ccttcttcag gattttatat gtgaagagatttttatatag
77101 atttttttcc tttttttcca aaacacttta tactttaaaa aaaaaaaaaaaaagcaattc
77161 ctggtggctg tgtgcctcca accctggtcc ccctctgtct ccagccaccctctgcttggg
77221 cttctgagct ggtggccctg gcccagaggt ctggcggagg cccaggcagcagccatggcg
77281 gggtgtctct acaggggaga ggcgggagcc tgccaccctc ttcctgccctacctcctact
77341 aacacttcct gccccatttg gacccgtacc atggggctca ggacagagggagctagcagc
77401 tggcctccat ggccccacag cctccttcga ggctgtgctg ggtgcagaaccgccagagcc
77461 acccaaaagg tgtttctctt ctgctccctg aacctcttaa cttaataaaacgttccagca
77521 gctctggtgt cctagatggc tggcagaaca ggaatggaga ttggggtttcttgaagtggc
77581 ttccccactc acaccctacc cacaccccac ccttcctaaa gcagcggcctctaggcttct
77641 gagggtgggg ctgaaaatcc aaggtctccc ttagtacaga ctgtgacgcccccagtgtgg
77701 cttgcaggct agtggcagcg gaagcatgtg ggaaatagca agtccagtcccaccccaacc
77761 tactgaacca gcgtctgcat tttaacaggg tgccccagtg attcacgtgaccttcaaagt
77821 ctgaggagcc ctggagtagg gcccagggcc caggcctgag agagaggcctggggctaaga
77881 ctagccctga ccatgacctt gggcaagtca cacccctcac tgagcctcagtttgcttctc
77941 catcaaatgg gtgtttttct ttcagtccca gtcctctcct gaggcttttcccagaggtca
78001 tgcccagccc tgggcagggg tgagggcagg gttgtggctg ccaggcacaggtccagcggg
78061 ctgggagtcc tcaccatggc tggctgtgct gattatggtt gcatggggctgggaagaggt
78121 cccatttctg agccacagaa acaggccaca tccagtaggg gtcctggaaggctgtgagaa
78181 cccagaggag accctgaccc agcctgcagg tagaagactg cctttggaggcagctttgaa
78241 agatgactct tccagatgga agaatcagga agggccttcc cacgtggaggcaccagcagg
78301 agcaaacgtc cctggtgtgt tcaggcaaag agccacagga gagtgacctcgtggagtggg
78361 aagagattgt ttcccattcc cttgccaggg attggttgag gaatggacaaggcttgcagt
78421 tcacgcaagc cagtgaaatg cgaggggaag tcttgggagt ggggtggaggaggtcatctg
78481 ggaagggtgt ccttggtctt aaaaagaggc acaagaggcc gggcgcggtggctcttgcct
78541 attatcctag cactttggga ggccaaggca gggggatcac ttgaggtcaggagttcgaga
78601 ccagcctggc caacatggtg aaaccccgtc tctactaaaa atacaaaaaattagccagac
78661 gtggtgccaa gcacctgtaa tcccagctac tcaggaggct gaggcaggagaatcacttga
78721 acccaggagg cagaagttgc agtgagccaa gatcgcgcca ctgcactccagcctgtgtga
78781 caagggcgaa actccatctc aaaaaaaaag ggggagggtg gcgcaaggagaggacacctc
78841 tctcctggcc ctgtcgccat cttccctcat caatagctaa aaatggcaaagaagaaagag
78901 ccaggacccc gtgccatcaa atcctccggc cttgtgctgc cctgtctcggcactgcttgc
78961 cttaggagat caggagtgtt cctagccact gggagatggg atgcctgccactggcagctc
79021 tgccgtccat cctcaccatc ccaccgtccc cccaagacag ctctccatcccatcctctgc
79081 ctcccttcta gcctcaacct aactcagggc tcccccgtct cacacctgggttgcaggaac
79141 atcctcttca ccaacccccc tcccatccct cctcagggct gcctagggcagctacaaaaa
79201 ccaggccagc ctctgaaagg tgctccacat ctcattaaaa accgtgaaatcgcactgccc
79261 cactatcaga atagctcaga ggagaaggtc tgccagtacc aagtgctggtggggatacgg
79321 agaagagcag ctcccaggcg ctgctggtgc aaatgtgctt tgttgcacccacggcaggaa
79381 actgaccagc ttctcatcaa gttaaatacg catctaccct atggcctagcatttccactc
79441 ttgcttacac atccaggaga aatgagtcct tacatgcaca aaaggatgagtaccgtaata
79501 ctcacatcag caaataaaca atacagctgt gtgtcagtag tagaatgaataaattgtggt
79561 cgattcata
硬纤毛蛋白
STRC基因编码硬纤毛蛋白，一种通常在内耳中表达并与内耳中特化的毛细胞的静纤毛相关联的蛋白(参见，例如，Verpy等人，Nature456:255-258,2008；和Zhang等人，J.Med.Genet.44:233-240,2007)。长度为约10-50μm的静纤毛对于听力和平衡是重要的。静纤毛在听力中起着机械感应作用。通过响应于声音而弯曲，它们形成了机械接收声音刺激的结构。
人STRC基因位于染色体15q15上。其包含29个外显子，涵盖约19千碱基(kb)(Verpy等人，Nature Genetics 29(3):345-349,2001；NCBI登录号NG011636.1)。所述基因以端粒至着丝粒的取向在染色体15q15上串联复制，其中串联拷贝在染色体上的间隔小于100kb。第二拷贝的编码序列间杂有外显子20中的终止密码子，这意味着其是编码非功能性截短蛋白的“假基因”。(此后，提及“STRC基因”意指在外显子20中没有终止密码子的基因，而提及“假基因”或“STRC假基因”则表示在外显子20中具有终止密码子的基因)。在一些实例中，全长STRC蛋白是全长野生型STRC蛋白。从人STRC基因表达的全长野生型STRC蛋白的长度为1775个残基，并包含信号肽和几个疏水区段。当信号肽在野生型蛋白的加工过程中被切割掉时，所得的成熟野生型硬纤毛蛋白的长度为1719个残基。在一些实施方案中，全长STRC蛋白可包含位于成熟野生型硬纤毛蛋白的氨基酸序列的N-末端的异源信号肽。
STRC基因中的各种突变已与听力损失(例如，非症状性感音神经性听力损失)相关联。例如，在具有常染色体隐性非综合征性感音神经性耳聋-16(DFNB16)的近亲巴基斯坦家族中的外显子13中鉴定出纯合的1bp插入(Verpy等人(2001)。在具有DFNB16的家族中发现的另一个实例包括外显子5中的4bp缺失和涵盖外显子17-29的较大缺失。这两个缺失分别遗传自父亲和母亲。预测4bp缺失会导致5个框外氨基酸的翻译和外显子5中的提前终止密码子。
在具有非症状性感音神经性听力损失的受试者中检测到的硬纤毛蛋白基因中的其它示例性突变以及编码硬纤毛蛋白的核酸的测序方法描述于例如Verpy等人，Nature456:255-259,2008；Verpy等人，Res.Systems Neurosci.519:194-210,2011；Hofrichter等人，Clinical Genetics 87:49-55,2015和Mandelker等人，J.Mol.Diagnostics 16:639-647,2014中。检测基因中的突变的方法是本领域公知的。此类技术的非限制性实例包括：实时聚合酶链式反应(RT-PCR)、PCR、测序、Southern印迹和Northern印迹。
示例性人野生型硬纤毛蛋白为或包括SEQ ID NO:34的序列。编码野生型硬纤毛蛋白的核酸的非限制性实例为或包括SEQ ID NO:35和SEQ ID NO:36。如在本领域中可理解的，可对SEQ ID NO:35中的至少一些或全部密码子进行密码子优化以允许在非人哺乳动物中或人中的最佳表达。
在本文所述的任何组合物的一些实施方案中，STRC蛋白包含与SEQ ID NO:34具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
人全长野生型硬纤毛蛋白(SEQ ID NO:34)(信号序列以粗体显示)
Figure BDA0003112389540002161
Figure BDA0003112389540002171
人野生型硬纤毛蛋白cDNA(SEQ ID NO:35)
atggctctcagcctctggcccctgctgctgctgctgctgctgctgctgctgctgtcctttgcagtgactctggcccctactgggcctcattccctggaccctggtctctccttcctgaagtcattgctctccactctggaccaggctccccagggctccctgagccgctcacggttctttacattcctggccaacatttcttcttcctttgagcctgggagaatgggggaaggaccagtaggagagcccccacctctccagccgcctgctctgcggctccatgattttctagtgacactgagaggtagccccgactgggagccaatgctagggctgctaggggatatgctggcactgctgggacaggagcagactccccgagatttcctggtgcaccaggcaggggtgctgggtggacttgtggaggtgctgctgggagccttagttcctgggggcccccctaccccaactcggcccccatgcacccgtgatgggccgtctgactgtgtcctggctgctgactggttgccttctctgctgctgttgttagagggcacacgctggcaagctctggtgcaggtgcagcccagtgtggaccccaccaatgccacaggcctcgatgggagggaggcagctcctcactttttgcagggtctgttgggtttgcttaccccaacaggggagctaggctccaaggaggctctttggggcggtctgctacgcacagtgggggcccccctctatgctgcctttcaggaggggctgctccgtgtcactcactccctgcaggatgaggtcttctccattttggggcagccagagcctgataccaatgggcagtgccagggagttttcttccttactctttccctcctaggtaaccttcaacagctgctcttatggggcgtccggcacaacctttcctgggatgtccaggcgctgggctttctgtctggatcaccacccccaccccctgccctccttcactgcctgagcacgggcgtgcctctgcccagagcttctcagccgtcagcccacatcagcccacgccaacggcgagccatcactgtggaggccctctgtgagaaccacttaggcccagcaccaccctacagcatttccaacttctccatccacttgctctgccagcacaccaagcctgccactccacagccccatcccagcaccactgccatctgccagacagctgtgtggtatgcagtgtcctgggcaccaggtgcccaaggctggctacaggcctgccacgaccagtttcctgatgagtttttggatgcgatctgcagtaacctctccttttcagccctgtctggctccaaccgccgcctggtgaagcggctctgtgctggcctgctcccaccccctaccagctgccctgaaggcctgccccctgttcccctcaccccagacatcttttggggctgcttcttggagaatgagactctgtgggctgagcgactgtgtggggaggcaagtctacaggctgtgccccccagcaaccaggcttgggtccagcatgtgtgccagggccccaccccagatgtcactgcctccccaccatgccacattggaccctgtggggaacgctgcccggatgggggcagcttcctggtgatggtctgtgccaatgacaccatgtatgaggtcctggtgcccttctggccttggctagcaggccaatgcaggataagtcgtgggggcaatgacacttgcttcctagaagggctgctgggcccccttctgccctctctgccaccactgggaccatccccactctgtctgacccctggccccttcctccttggcatgctatcccagttgccacgctgtcagtcctctgtcccagctcttgctcaccccacacgcctacactatctcctccgcctgctgaccttcctcttgggtccaggggctgggggcgctgaggcccaggggatgctgggtcgggccctactgctctccagtctcccagacaactgctccttctgggatgcctttcgcccagagggccggcgcagtgtgctacggacgattggggaatacctggaacaagatgaggagcagccaaccccatcaggctttgaacccactgtcaaccccagctctggtataagcaagatggagctgctggcctgctttagtcctgtgctgtgggatctgctccagagggaaaagagtgtttgggccctgcagattctagtgcaggcgtacctgcatatgcccccagaaaacctccagcagctggtgctttcagcagagagggaggctgcacagggcttcctgacactcatgctgcaggggaagctgcaggggaagctgcaggtaccaccatccgaggagcaggccctgggtcgcctgacagccctgctgctccagcggtacccacgcctcacctcccagctcttcattgacctgtcaccactcatccctttcttggctgtctctgacctgatgcgcttcccaccatccctgttagccaacgacagtgtacagcagggctacagagggtcagaggaaaacagtttggaggaagacaaagggttaagacccatgactcctcgcagcctggctgccatccgggattacagcccaggaatgaggcctgaacagaaggaggctctggcaaagcgactgctggcccctgaactgtttggggaagtgcctgcctggccccaggagctgctgtgggcagtgctgcccctgctcccccacctccctctggagaactttttgcagctcagccctcaccagatccaggccctggaggatagctggccagcagcaggtctggggccagggcatgcccgccatgtgctgcgcagcctggtaaaccagagtgtccaggatggtgaggagcaggtacgcaggcttgggcccctcgcctgtttcctgagccctgaggagctgcagagcctagtgcccctgagtgatccaacggggccagtagaacgggggctgctggaatgtgcagccaatgggaccctcagcccagaaggacgggtggcatatgaacttctgggtgtgttgcgctcatctggaggagcggtgctgagcccccgggagctgcgggtctgggcccctctcttctctcagctgggcctccgcttccttcaggagctgtcagagccccagcttagagccatgcttcctgtcctgcagggaactagtgttacacctgctcaggctgtcctgctgcttggacggctccttcctaggcacgatctatccctggaggaactctgctccttgcaccttctgctaccaggcctcagcccccagacactccaggccatccctaggcgagtcctggtcggggcttgttcctgcctggcccctgaactgtcacgcctctcagcctgccagaccgcagcactgctgcagacctttcgggttaaagatggtgttaaaaatatgggtacaacaggtgctggtccagctgtgtgtatccctggtcagcagcctattcccaccacctggccagactgcctgcttcccctgctcccattaaagctgctacaactggattccttggctcttctggcaaatcgaagacgctactgggagctgccctggtctgagcagcaggcacagtttctctggaagaagatgcaagtacccaccaaccttaccctcaggaatctgcaggctctgggcaccctggcaggaggcatgtcctgtgagtttctgcagcagatcaactccatggtagacttccttgaagtggtgcacatgatctatcagctgcccactagagttcgagggagcctgagggcctgtatctgggcagagctacagcggaggatggcaatgccagaaccagaatggacaactgtagggccagaactgaacgggctggatagcaagctactcctggacttaccgatccagttgatggacagactatccaatgaatccattatgttggtggtggagctggtgcaaagagctccagagcagctgctggcactgacccccctccaccaggcagccctggcagagagggcactacaaaacctggctccaaaggagactccagtctcaggggaagtgctggagaccttaggccctttggttggattcctggggacagagagcacacgacagatccccctacagatcctgctgtcccatctcagtcagctgcaaggcttctgcctaggagagacatttgccacagagctgggatggctgctattgcaggagtctgttcttgggaaaccagagttgtggagccaggatgaagtagagcaagctggacgcctagtattcactctgtctactgaggcaatttccttgatccccagggaggccttgggtccagagaccctggagcggcttctagaaaagcagcagagctgggagcagagcagagttggacagctgtgtagggagccacagcttgctgccaagaaagcagccctggtagcaggggtggtgcgaccagctgctgaggatcttccagaacctgtgccaaattgtgcagatgtacgagggacattcccagcagcctggtctgcaacccagattgcagagatggagctctcagactttgaggactgcctgacattatttgcaggagacccaggacttgggcctgaggaactgcgggcagccatgggcaaagcaaaacagttgtggggtcccccccggggatttcgtcctgagcagatcctgcagcttggtaggctcttaataggtctaggagatcgggaactacaggagctgatcctagtggactggggagtgctgagcaccctggggcagatagatggctggagcaccactcagctccgcattgtggtctccagtttcctacggcagagtggtcggcatgtgagccacctggacttcgttcatctgacagcgctgggttatactctctgtggactgcggccagaggagctccagcacatcagcagttgggagttcagccaagcagctctcttcctcggcaccctgcatctccagtgctctgaggaacaactggaggttctggcccacctacttgtactgcctggtgggtttggcccaatcagtaactgggggcctgagatcttcactgaaattggcaccatagcagctgggatcccagacctggctctttcagcactgctgcggggacagatccagggcgttactcctcttgccatttctgtcatccctcctcctaaatttgctgtggtgtttagtcccatccaactatctagtctcaccagtgctcaggctgtggctgtcactcctgagcaaatggcctttctgagtcctgagcagcgacgagcagttgcatgggcccaacatgagggaaaggagagcccagaacagcaaggtcgaagtacagcctggggcctccaggactggtcacgaccttcctggtccctggtattgactatcagcttccttggccacctgctatga
人野生型硬纤毛蛋白cDNA-经密码子优化的(SEQ ID NO:36)
atggctctgtctctgtggcctctgctgctgctcctgttgctgcttctgctgctcagcttcgccgtgacactggctccaacaggaccccactctctggatcctggcctgagctttctgaagtccctgctgagcaccctggatcaggctcctcagggcagcctgagcagatccagattcttcaccttcctggccaacatcagcagcagcttcgagcctggcagaatgggagaaggacctgtgggagaacctcctccactgcaacctccagctctgcggctgcacgattttctggtcacactgagaggcagccccgactgggaacctatgctgggactgctgggagatatgctggccctgctcggacaagagcagacccctagagatttcctggtgcatcaggctggcgtgctcggaggactggttgaagttctgcttggagcactggtgcctggcggacctcctacacctacaagacctccatgcaccagagatggccccagcgattgtgtgctggctgctgattggctgcctagcctgctcctgcttctggaaggcacaagatggcaggccctggtgcaggttcagccttctgtggatcctaccaatgccaccggcctggatggaagagaagccgctccacactttctgcagggactgcttggactgctcacacctactggcgagctgggctctaaagaagccctttggggaggcctgctgagaacagttggagcccctctgtacgccgcctttcaagagggactcctgagagtgacacacagcctgcaggacgaggtgttcagcatcctgggacagccagagcctgacaccaatggacagtgtcagggcgtgttctttctgaccctgagcctgctgggcaacctgcagcaactgcttctgtggggcgtcagacacaacctgagctgggatgtgcaggcactgggctttctgtctggaagccctccacctccaccagcactgctgcattgtctgtctactggcgtgccactgcctagagcctctcagcctagcgctcacatcagccccagacagagaagggccatcaccgtggaagctctgtgcgagaatcacctgggacctgctcctccatacagcatcagcaacttctccatccatctgctgtgtcagcacaccaagcctgccacacctcagcctcatcctagcaccacagccatctgtcagaccgccgtttggtacgccgtttcttgggctcctggtgctcaaggatggctgcaggcctgtcacgatcagttccccgacgagttcctggacgccatctgcagcaatctgagcttctctgccctgtccggcagcaatcggagactggtcaaaagactgtgcgccggactgctgcctcctccaacatcttgtcctgagggactgcctcctgtgcctctgactcccgatatcttttggggctgcttcctggaaaacgagacactgtgggccgagagactgtgtggcgaagcctctctgcaagccgtgcctccatctaatcaggcctgggtgcagcacgtttgtcagggccctacacctgacgtgacagcctctcctccttgtcacatcggaccttgcggcgagagatgtcctgatggcggcagctttctcgtgatggtctgcgccaacgacactatgtacgaggtgctggtgcccttctggccttggctggctggccagtgtagaatctccagaggcggcaacgatacctgtttcctggaaggactcctgggaccactgcttccatctctgcctccgcttggaccctctcctctgtgtcttacccctggacctttcctgctggggatgctgtctcagctgcctagatgccagtctagcgtgccagctctggcccatccaaccagactgcactatctgttgcggctgctgaccttcctccttggacctggcgctggcggagctgaagctcaaggcatgcttggcagagccctgctgctgtcatccctgcctgacaactgcagcttctgggacgccttcagacctgaaggacgcagaagcgtgctgaggaccatcggcgagtacctggaacaggatgaggaacagcctacaccaagcggcttcgaacccaccgtgaatcctagcagcggcatctccaagatggaactgctggcctgcttcagccccgtgctgtgggatctgctgcagagggaaaaaagcgtgtgggccctgcagatcctggtccaggcctatctgcacatgcctccagagaacctgcaacagctggtgctgtctgccgagagagaagctgcccagggattcctgactctgatgctgcagggaaagctgcagggcaaactccaggtgccacctagcgaagaacaggcccttggcagactgacagcactcctgctccagagataccccagactgacctctcagctgtttatcgatctgagccctctgatcccattcctggccgtgtccgacctgatgagattccctcctagtctgctggccaacgactccgtgcagcagggatacagaggcagcgaggaaaacagcctggaagaggacaaaggcctgcggcctatgacacctagatctctggccgccatccgggattacagccctggaatgaggcccgagcagaaagaggccctggctaagagactgctggctcccgagctgtttggcgaagttccagcctggcctcaagaactgctgtgggctgttctgcccctgctgccacatctgcctctggaaaacttcctgcagctgagcccacaccagattcaggccctcgaggattcttggcctgccgctggactcggacctggacatgctagacacgtgctgagaagcctggtcaaccagagcgttcaggacggcgaggaacaagtgcggagacttggacccctggcctgttttctgagccccgaggaactgcagagtctggtgcctctgtctgaccctacaggccctgttgaaaggggcctgctggaatgtgccgccaatggaacactgagccctgagggcagagtggcctatgaacttctgggagtgctgagatctagcggcggagccgttctgtcccctagggaacttagagtgtgggcacccctgtttagccagctgggcctgagattcctgcaagagctgtctgagccacagctgagggctatgctgcctgtgctccagggcacatctgtgacaccagctcaagccgtcctgctgttgggcagactgctccctagacacgatctgtccctggaagaactgtgcagcctgcacttgctgctgcctggactgtctcctcagacactgcaggccattcctcggagagtgcttgtgggagcctgtagctgtctggcccctgagctgtctagactgagcgcctgtcaaacagccgctctcctgcagaccttcagagtgaaggatggcgtgaagaacatgggcaccacaggcgctggacctgccgtgtgtattcctggacagcagcccattcctaccacctggccagattgtctgctcccactgctgcccctgaaactgctgcagctggattctctggctctgctggctaaccggcggagatattgggaactgccttggagcgaacagcaggcacagttcctgtggaagaagatgcaggtccccaccaatctgacactgcggaatctgcaggctctcggcacacttgctggcggaatgagctgcgagttcctccagcagatcaacagcatggtggactttctggaagtggtgcacatgatctaccagctgccaaccagagtgcggggaagcctgagagcttgtatttgggctgaactgcagcggcggatggccatgcctgaacctgaatggacaacagtgggccccgagctgaacggcctggactctaaacttctgctggatctccccatccagctgatggacagactgagcaacgagagcatcatgctggtggtggaactggtgcagagagccccagaacagctgctggcactgacacctctgcatcaagctgctctggccgaacgggcccttcagaatctggctcccaaagaaacccctgtgtccggggaagtgctggaaacactgggacctcttgtgggcttcctgggcaccgagtctaccagacagattcctctccagatcctgctgtcccacctgagccagctccagggattttgtctgggcgagacattcgccaccgaactcggatggttgctgctccaagagagcgtgctgggaaagcccgaactgtggtcacaggacgaagtggaacaggccggcagactggtgtttaccctgtctaccgaggccatcagtctgatccccagagaagcactgggccctgaaacactcgagaggctgctggaaaagcagcagtcttgggaacagagcagagtgggccagctgtgtagagaacctcagctggccgctaaaaaggccgcactggttgctggcgttgtcagacctgctgccgaggatctgccagagccagtgcctaattgtgccgatgtgcggggcacatttcctgccgcttggagcgctacacagatcgccgaaatggaactgagcgacttcgaggactgtctgactctgtttgccggcgatcctggactgggaccagaagaactgagagccgccatgggcaaagccaagcaactttggggacctccaagaggcttcagacccgaacagattctgcagctcggccgcctgcttatcggactgggcgatagagagctgcaagaactgatcctggtggactggggcgtgctgtctactctgggacaaatcgacggctggtccaccacacagctgcggattgtggtgtccagcttcctgaggcagtctggcagacatgtgtctcacctggacttcgtgcacctgactgccctgggctacacactgtgtggactgcggcctgaggaacttcagcacatcagctcttgggagttcagccaggcagccctgtttctgggaaccctgcatctgcagtgctccgaagaacaactggaagtgctcgcccatctgctcgtgctgccaggcggatttggccccatctctaattggggacccgagatcttcaccgagatcggcaccattgccgctggcatccctgatctggccctgtctgcactgctgagaggacagatccagggcgtgacaccactggccattagcgtgatccctccaccaaagttcgccgtggtgtttagccccattcagctgtccagcctgacatctgcccaagccgtggctgtgacccctgaacagatggcatttctgtctcccgagcagcggagagctgttgcttgggctcaacacgagggcaaagagagtcctgagcaacagggaagaagcaccgcttggggactgcaggattggtccagaccttcttggtcactggtgctgaccatcagctttctgggccacctcctgtga
人野生型硬纤毛蛋白(Stereocilin)基因DNA序列的非限制性实例是SEQ ID NO:37。SEQ ID NO:37中的外显子是：核苷酸位置1-142(外显子1)、核苷酸位置445-1230(外显子2)、核苷酸位置1319-1343(外显子3)、核苷酸位置2111-3368(外显子4)、核苷酸位置4325-4387(外显子5)、核苷酸位置4489-4605(外显子6)、核苷酸位置4748-4914(外显子7)、核苷酸位置5570-5756(外显子8)、核苷酸位置5895-6010(外显子9)、核苷酸位置6292-6424(外显子10)、核苷酸位置6777-6959(外显子11)、核苷酸位置7264-7302(外显子12)、核苷酸位置7486-7653(外显子13)、核苷酸位置7817-7882(外显子14)、核苷酸位置8364-8489(外显子15)、核苷酸位置9467-9525(外显子16)、核苷酸位置10598-10721(外显子17)、核苷酸位置10826-10938(外显子18)、核苷酸位置13402-13537(外显子19)、核苷酸位置13955-14151(外显子20)、核苷酸位置14350-14440(外显子21)、核苷酸位置14649-14805(外显子22)、核苷酸位置15390-15559(外显子23)、核苷酸位置17250-17405(外显子24)、核苷酸位置17787-17929(外显子25)、核苷酸位置18119-18267(外显子26)、核苷酸位置18509-18605(外显子27)、核苷酸位置18694-18841(外显子28)和核苷酸位置19041-19238(外显子29)。内含子位于SEQ ID NO:37中的这些外显子中的每一个外显子之间，即，处于核苷酸位置143-444(内含子1)、核苷酸位置1231至1318(内含子2)、核苷酸位置1344-2110(内含子3)、核苷酸位置3369-4324(内含子4)、核苷酸位置4388-4488(内含子5)、核苷酸位置4606-4747(内含子6)、核苷酸位置4915-5569(内含子7)、核苷酸位置5757-5894(内含子8)、核苷酸位置6011-6291(内含子9)、核苷酸位置6425-6776(内含子10)、核苷酸位置6960-7263(内含子11)、核苷酸位置7303-7485(内含子12)、核苷酸位置7654-7816(内含子13)、核苷酸位置7883-8363(内含子14)、核苷酸位置8490-9466(内含子15)、核苷酸位置9526-10597(内含子16)、核苷酸位置10722-10825(内含子17)、核苷酸位置10939-13401(内含子18)、核苷酸位置13538-13954(内含子19)、核苷酸位置14152-14349(内含子20)、核苷酸位置14441-14648(内含子21)、核苷酸位置14806-15389(内含子22)、核苷酸位置15560-17249(内含子23)、核苷酸位置17406-17786(内含子24)、核苷酸位置17930-18118(内含子25)、核苷酸位置18268-18508(内含子26)、核苷酸位置18606-18693(内含子27)和核苷酸位置18842-19040(内含子28)。
人野生型硬纤毛蛋白基因(SEQ ID NO:37)(NCBI登录号NG_011636.1)
1 gccctgccct cacctggcta tcccacacag gtgagaataa ccagaactca cctccggtac
61 cagtgttcac ttggaaacat ggctctcagc ctctggcccc tgctgctgct gctgctgctg
121 ctgctgctgc tgtcctttgc aggtaagaag aacagtgagc agaactgggg atgaggagga
181 gggtggctgg aaaaagactt taagaatatg gaggtgaacc tgttagatag aaggacaaag
241 gagagaggca gagacttgtg caaaagggaa aaatgagggt taagaaaagc aggccaagac
301 ttactgtagg ccagtgaaag gggttcagct caccatcccc tcacctcatc tttagatcca
361 ggtagggaac tgtgctcagg ggcagggttg agtttgggct ctgtgttcct ctccttcagt
421 gacctctggt ttctctcctt acagtgactc tggcccctac tgggcctcat tccctggacc
481 ctggtctctc cttcctgaag tcattgctct ccactctgga ccaggctccc cagggctccc
541 tgagccgctc acggttcttt acattcctgg ccaacatttc ttcttccttt gagcctggga
601 gaatggggga aggaccagta ggagagcccc cacctctcca gccgcctgct ctgcggctcc
661 atgattttct agtgacactg agaggtagcc ccgactggga gccaatgcta gggctgctag
721 gggatatgct ggcactgctg ggacaggagc agactccccg agatttcctg gtgcaccagg
781 caggggtgct gggtggactt gtggaggtgc tgctgggagc cttagttcct gggggccccc
841 ctaccccaac tcggccccca tgcacccgtg atgggccgtc tgactgtgtc ctggctgctg
901 actggttgcc ttctctgctg ctgttgttag agggcacacg ctggcaagct ctggtgcagg
961 tgcagcccag tgtggacccc accaatgcca caggcctcga tgggagggag gcagctcctc
1021 actttttgca gggtctgttg ggtttgctta ccccaacagg ggagctaggctccaaggagg
1081 ctctttgggg cggtctgcta cgcacagtgg gggcccccct ctatgctgcctttcaggagg
1141 ggctgctccg tgtcactcac tccctgcagg atgaggtctt ctccattttggggcagccag
1201 agcctgatac caatgggcag tgccagggag gtgagtgtgg ccagggctgggactgggatg
1261 tggcagggca aggaaagtga aattggggta gttttcttcc ttactctttccctcctaggt
1321 aaccttcaac agctgctctt atggtaagta acaggagacc agttctgagggattgggcct
1381 ggaaaatctg gaggtgaaga gctgaagacc tcagcctcta gagaggaaaactgatgggag
1441 gagtgtagtt tagtggtttt ggggtgtgac tgtctgggtt ggtgtcccagctccacctct
1501 tcctagccat atgaccttga gcaggttaca tagtctttct atacctcagtttccccattt
1561 ataaaatgag aatgataata ttagttacca cagagttgtt gcacccggttaaatgagttg
1621 atactgtgta tgcaaacgac ttaaaaccgt gctggcacat agcgcttaataatgttagct
1681 agtaaagatg ggatttggaa aataaggaca cagctggatt cctctacccccttactactt
1741 cagtacaaca atgccagaca gtagttagac atattgagtt gctgagcagatttcctaaca
1801 tgaggcccgc tgagggttgt gtttaagcta tctaaaagca tacgaagaaaggagacagaa
1861 gggggccagg tggacagaaa gaattccaac tggggcttct cctaggtgattttggacctt
1921 ggcagggcag ctttctcttt tttgccccgt tgcagcattt caaccagtaacgcctaaact
1981 ctcagggacc tcgcttgtag aaaagcctat gcttgccatg ccccttgagggctctgagtc
2041 agggtcagaa tcttcagctg gaggaaatgt gaactgacca gatcctgcctgctcctccct
2101 ctgcacccag gggcgtccgg cacaaccttt cctgggatgt ccaggcgctgggctttctgt
2161 ctggatcacc acccccaccc cctgccctcc ttcactgcct gagcacgggcgtgcctctgc
2221 ccagagcttc tcagccgtca gcccacatca gcccacgcca acggcgagccatcactgtgg
2281 aggccctctg tgagaaccac ttaggcccag caccacccta cagcatttccaacttctcca
2341 tccacttgct ctgccagcac accaagcctg ccactccaca gccccatcccagcaccactg
2401 ccatctgcca gacagctgtg tggtatgcag tgtcctgggc accaggtgcccaaggctggc
2461 tacaggcctg ccacgaccag tttcctgatg agtttttgga tgcgatctgcagtaacctct
2521 ccttttcagc cctgtctggc tccaaccgcc gcctggtgaa gcggctctgtgctggcctgc
2581 tcccaccccc taccagctgc cctgaaggcc tgccccctgt tcccctcaccccagacatct
2641 tttggggctg cttcttggag aatgagactc tgtgggctga gcgactgtgtggggaggcaa
2701 gtctacaggc tgtgcccccc agcaaccagg cttgggtcca gcatgtgtgccagggcccca
2761 ccccagatgt cactgcctcc ccaccatgcc acattggacc ctgtggggaacgctgcccgg
2821 atgggggcag cttcctggtg atggtctgtg ccaatgacac catgtatgaggtcctggtgc
2881 ccttctggcc ttggctagca ggccaatgca ggataagtcg tgggggcaatgacacttgct
2941 tcctagaagg gctgctgggc ccccttctgc cctctctgcc accactgggaccatccccac
3001 tctgtctgac ccctggcccc ttcctccttg gcatgctatc ccagttgccacgctgtcagt
3061 cctctgtccc agctcttgct caccccacac gcctacacta tctcctccgcctgctgacct
3121 tcctcttggg tccaggggct gggggcgctg aggcccaggg gatgctgggtcgggccctac
3181 tgctctccag tctcccagac aactgctcct tctgggatgc ctttcgcccagagggccggc
3241 gcagtgtgct acggacgatt ggggaatacc tggaacaaga tgaggagcagccaaccccat
3301 caggctttga acccactgtc aaccccagct ctggtataag caagatggagctgctggcct
3361 gctttagtgt gagtgctctg ccagagggaa agctcctaga acagtgagaaggccctccag
3421 gggaattcct cgaatactca gaggcagtag tgtggggtag tagttgaagcacacagctct
3481 agagtcagac aggcttggat tcatatcttg gttctgtgac cagccttgaatgagttattt
3541 aacttctctg agcaatattt ttctcgtctc atttataaac tagggatgataatggtatat
3601 gagataatac atgctgtggg cttagcacag tgcatgatac acaaacatgcaataaatatt
3661 accttgttat tcttttgggc tctttgactc tctcactttc tgcaccagaaagaaaaagga
3721 tcaagttaga ggactctaaa tttttcccct agagagtgag aattggaggctggcagaata
3781 caggaagata aggtaggaat gagaaagatt cagggacact accaatcagaagactttggt
3841 tctaggttca actgtgccac aaattagtgt gatcttaggc aagcaatttcatttagtttt
3901 tctgggcttc agtttttagt ctgtagaatg gaggggtgag aatatgttaaacaccataat
3961 taattcactg agtgcctatt atatgcaagg cactttgcta ggttctgtaggatatataaa
4021 gatttcttac tccatgttgg ggccaccttt ttcaaaccct gggcccagtaaaatggaatt
4081 agatagtctc atagtatttg gttcaggtct acaagtatta attgagccaactatggacct
4141 ggcatgggag agggtacaag agaaattaga gatatgatcc cggacctaaaagagcttaat
4201 atctgaagaa tcacacttga gatgatggac aagcatccca gcaagtggagctggaatgcc
4261 tgggggagct gcaggagaga cagagaagac agctctgttg gcatattgtctttcttccca
4321 ccagcctgtg ctgtgggatc tgctccagag ggaaaagagt gtttgggccctgcagattct
4381 agtgcaggta acaggtggag ggcacatggg tgggctgggt gacagccatggctggaggtc
4441 cctgccccgt gaggtgaggc catacccacc atgacctcct attcgcaggcgtacctgcat
4501 atgcccccag aaaacctcca gcagctggtg ctttcagcag agagggaggctgcacagggc
4561 ttcctgacac tcatgctgca ggggaagctg caggggaagc tgcaggtgagcactgagaaa
4621 ggggagcaag ggcacctgga gcctagtgtt cagagggctt gctttagtgggaggaggaac
4681 tccagagagg aaatggcagg gatactgagc atctccagag gcagaatccattcctgtgcc
4741 cctacaggta ccaccatccg aggagcaggc cctgggtcgc ctgacagccctgctgctcca
4801 gcggtaccca cgcctcacct cccagctctt cattgacctg tcaccactcatccctttctt
4861 ggctgtctct gacctgatgc gcttcccacc atccctgtta gccaacgacagtgtgtaagg
4921 ttcttgcact actcctcctg ctcctgtcac ggtcaggcca accgcatccacctggagcag
4981 ccccttccgg agctcctctc tgtttttttc tttcatgcca gataggcaatgtgccaacat
5041 cgtagcaagg tttgagagag gcacatctca cgcctgagtg tgaaaacccaatcattatgc
5101 taatgaacta caaaaggatc agagagctcc tctctattaa aaccagggagaggatgggcg
5161 tggtggctca tgcctgtaat cccagcacgt tgggagcccg aggcaggtggatcactaggt
5221 ccgcctagtg agttcgagac cagcctggcc aatatggtga aaccccgtctctattaaact
5281 acaaaaatta gccaggcatg gtggtgggcg cttgtagtcc cagttactctggaggctgag
5341 gcaggaggat agcttgaacc tgggaggcag aggttgcagt gaaccaagatcgtgccactg
5401 cactccagcc tgggtgacag agcgagactc cgtcttaaaa aaaacaaaaaacaaaacaaa
5461 acaaaaaaac agggagagtc tccttcctat ctagacagca gggctacagagggtcagagg
5521 aaaacagttt ggaggaagac aaagggttaa gacccatgac tcctcgcagcctggctgcca
5581 tccgggatta cagcccagga atgaggcctg aacagaagga ggctctggcaaagcgactgc
5641 tggcccctga actgtttggg gaagtgcctg cctggcccca ggagctgctgtgggcagtgc
5701 tgcccctgct cccccacctc cctctggaga actttttgca gctcagccctcaccaggtat
5761 gagaatcatc ttctttactt gactggccca tcttctgcta gtggggacaaagagtcaatg
5821 gcatgtctct cagtggcccc tccctgcaag aaccctatag tgaccccagtgcgagctaac
5881 cttccccatc tcagatccag gccctggagg atagctggcc agcagcaggtctggggccag
5941 ggcatgcccg ccatgtgctg cgcagcctgg taaaccagag tgtccaggatggtgaggagc
6001 aggtacgcag gtgagttgtt gtgggatcag taaccaaggc aagagtggaagaggtagaga
6061 gaggaaggca cagctgtcac gctgggtcgg tgttctagga agaaaggggcaagagagtag
6121 gcagtggcct caggcagcat agagttccag gagagaggtc tatagatggtgcccctgtgt
6181 agtggtgtag tgtcagagtg cccagtgtat gtacccatac catctgctgccaggcctgcc
6241 ttagtgctag tcttggggac cacacaaagg tcagcttcat gccctcctcaggcttgggcc
6301 cctcgcctgt ttcctgagcc ctgaggagct gcagagccta gtgcccctgagtgatccaac
6361 ggggccagta gaacgggggc tgctggaatg tgcagccaat gggaccctcagcccagaagg
6421 acgggtgagc ccctcagcac aagcctacaa gactttaggc ttcccctgggtctgtgtgga
6481 tggctttccc attgtgtcaa cttgagcaca gtggtgccag cccccatcccacttttgcaa
6541 cctccattcc ttactccatg gccattctta cctgttacca cctcttcctggcccttctct
6601 atctggtctg tagcacccca aacataccct ttgccatttt gaacctaatctactccagtc
6661 caatccctag ttccaaaccc tagcccaggc cctgggaaat tcagatgtgggattagagag
6721 gaagttcaag gttcatctgt cttttctctc cagtcctaaa ccttctttggttacaggtgg
6781 catatgaact tctgggtgtg ttgcgctcat ctggaggagc ggtgctgagcccccgggagc
6841 tgcgggtctg ggcccctctc ttctctcagc tgggcctccg cttccttcaggagctgtcag
6901 agccccagct tagagccatg cttcctgtcc tgcagggaac tagtgttacacctgctcagg
6961 tttgcctgtc tcactccctg gcatgtaccc tccatccccg cttgagccccagtcaagaga
7021 atcccattca gggataaaag cagcccctcc tttccctggg tgaacagtagaggtaaactc
7081 tgtctgcagg aggacgcctt cattcccttt cctcagatca agaagggacctgagtcactg
7141 aggatggtta ctagggatgg ttaagaggca gcgggaagtt ttggagggtttgccttagga
7201 acccacttag gacctggctg ctgggtcctg agagctgttg ttttcggtcccatcccaaca
7261 caggctgtcc tgctgcttgg acggctcctt cctaggcacg atgtgagtagcagcaacttc
7321 tcagcctccc gccagaggtc tctatcctct tttaacctgg ctcctgcatctgcccctcct
7381 ctctctccgc tcccctcata cttactgcct tgctgcattg tgattgttgtcttccccaac
7441 acccttccct tcttcttcag gcctcttgtc tctcttgctc tttagctatccctggaggaa
7501 ctctgctcct tgcaccttct gctaccaggc ctcagccccc agacactccaggccatccct
7561 aggcgagtcc tggtcggggc ttgttcctgc ctggcccctg aactgtcacgcctctcagcc
7621 tgccagaccg cagcactgct gcagaccttt cgggtatgag agtggcaaggaggatgagat
7681 aatcagggat accggctctt tctggttggg aggaaggcat cttccctgaggccagggaag
7741 gcctttcata cctccccact tacacacaca cacacacaca cacacacacacacacacaca
7801 accaattctc atgcaggtta aagatggtgt taaaaatatg ggtacaacaggtgctggtcc
7861 agctgtgtgt atccctggtc aggtaagtgt gagatctccc aactgagctcctctccccat
7921 tctggggcag tttcatatgg ctggtgctac ctcccacact accctgcagtggccctgaga
7981 gttctggtta gctctgtgcc cattagcagc cctccccagt gccagatgcaggacagcatg
8041 atccactcac attgtcctag actaatgtca aagctggaag ggcctgagaaatcttccagg
8101 ccacccaccc tgctttcaga tgaaaagacc aaggctggga gaagctaagggactttgttt
8161 gcctggtgcc taactagcag caacacttga ccacagcagc ctgcagtgtgaggctcttag
8221 gcgtttattg ctacagtggc aaatgccatt ccacttctgt cctagctttggtccctttcc
8281 acccccatgg ttccttttct ctgagtgcta agtacagact ctctcacctatcactacact
8341 gctataccca tcaccgccag cagcctattc ccaccacctg gccagactgcctgcttcccc
8401 tgctcccatt aaagctgcta caactggatt ccttggctct tctggcaaatcgaagacgct
8461 actgggagct gccctggtct gagcagcagg taattctccc cacttaatttcagaacttcc
8521 tccctcaatg tagtctacct tctttaccta tcccttagcc ctatttggccagcttatccc
8581 tactatcctt tatttgattg tttgagatac agtctcactc tgttgcccaggctgcagtgc
8641 agtggcatga tcagagttcg ctgtaacctc aaactcctga gctcaggcaatctttctgcc
8701 tcagcctcct gaatagctag gacgacaggt ggttaccacc atgcctggctaatttttaaa
8761 tttttttttt gttttttgag atgaagtctt gctctgtcac ccaggcttgagtacagtggc
8821 acaagcttgg ctcactgcaa cctctgtctc ccgggttcaa gcgattctcctgcctcagcc
8881 tcccgagtag ctgggactac aggcactccc cacaatgcct ggctaattttttttttgttt
8941 tagtagagac agggtttcac catattggcc aggctggtct cgaactgctgaccttgtgat
9001 ctgcctgcct ctgcctctca aagtgctggg attacaggtg tgagccaccatgcccggcca
9061 atttttaaat tttttgtaga gacagacaat acaaaaatgt ggacactatgtggagacact
9121 atgttgaggt actatgctgt ccagattggt cttgaactcc tggcctcaagcaatcctcct
9181 gccttggcct cccaaagtgc tgggattaca gacctgagcc actgcacccagccccctagt
9241 atctcttata atgtgacttg cttttctttt tctttctcct tcccttttctttcatttctt
9301 tctcactctc gagagaagag tgggcatctg ggagagtggg aggctggtgggtcccacaga
9361 gtgaggaggc aggactgggt ccaaggcagt cctgcctctc cactctagggggtatccttg
9421 gacagtgtct cttctgggaa ggggctcgtc tttctttctc ttgtaggcacagtttctctg
9481 gaagaagatg caagtaccca ccaaccttac cctcaggaat ctgcagtgagtaacttgtgt
9541 tgagcagtgc gctgaattcg accaacattt ttttgagtgc ttactatgtgccaggcacca
9601 tgtgatatgg aatgggggat atagggatga atgatgcata gtccctgcctcgtggacgtt
9661 ctcctagcac ctccctttgc cctcctttcc ttccacagtg ccatgcctatcctgactaga
9721 gccaaaggac tcagaaaacc tggattcagg ttccagtcct gtcacctacttgtcctcttg
9781 ggcaagtcat ttaacgtccc tgtgtcagtt ttcccttctt taaatgagaattacaatggc
9841 accagcctca taggtagtta ctgtgaagat taaatgaggt aggtcatgtaagatatttaa
9901 cacagtgttt ggtccattgt aaagtcccag tagtcatttg ctactgttagtttacttcag
9961 gatgacttca gaggcactgg ccaagcaaga ataaatagga ataagaaggtatcactttac
10021 ttacacccac attagaagaa caatgggctt cagaatcttt ttttttttttttttttcgag
10081 acagtcttgc tctgttgccc aggctggagt gcagtggcgc gatttcggctcactgcaacc
10141 tctgcctccc aggttcaagc gattctcctg tctcagcctc tggagtagctgggattacag
10201 gaatgtgcca ccatacccag ctaatttttg tatttttagt agagatggggtttcaccatt
10261 ttggccaggc tggtctcaaa ctcctgacct caggtgatcc acccgcctcagcctcccaag
10321 ggcttcagaa tctaagacat ggctctagtt tcagtttacc acatttctagcagaatgatg
10381 ttgggaatgt cacctgactt ccataaatcc ttattttctc ctctgataaacagcagtgat
10441 gttatgggga gctgatgaga tatctatgta aaaacatttc tcaaaccataaattacggtg
10501 gatgaacatc tgtacttgtg ttgagagtac tgatatcaag gagcaaacaggctgttgtat
10561 gtgttgaatg agcctctccc cactcacaca cccacagggc tctgggcaccctggcaggag
10621 gcatgtcctg tgagtttctg cagcagatca actccatggt agacttccttgaagtggtgc
10681 acatgatcta tcagctgccc actagagttc gagggagcct ggtgagagggggtgcctgga
10741 ctttagtggg agcagggagg ctgggaccct aggtatagaa cccagctcctatgttctgct
10801 ctggcctcac actgcttccc tacagagggc ctgtatctgg gcagagctacagcggaggat
10861 ggcaatgcca gaaccagaat ggacaactgt agggccagaa ctgaacgggctggatagcaa
10921 gctactcctg gacttaccgt aagtactgca gctagagata ttggcccctcagaaagctca
10981 atctggggtg aagatctgcc cttagggaat gccctggagg aggtagtttttctgtctggt
11041 agttccctga cataatttat agcccaaagc agaggatttt attcaaagttgctctatgta
11101 ttgactggtt cccagaatat gctccagcac agggcagctg agggtggcaacactgtattg
11161 aagcctgcca agtaatctta caataaccta gtccacatta attgagattgagacagagca
11221 tctgaagtga gggaggcaat gctccaaatc tgccccagag gattgtagtttgctcagggc
11281 actgtgttct tagtgcattc agaggagtag atcgagagaa aaatatatgaaaaatgtgat
11341 aaataccttc aaatacctga ggggctatca agtagaaatt agattgtcatatttatgagt
11401 ggccccattg ggcaagacta agagtagtta acggagatca gatttttacatagtataaga
11461 aaaactaagg tagtgagttc ctggtccttg gagctgttcg agcctaagccagatggcccc
11521 atggcaggaa tgttgtagag cacgttcata tacaggttgt gggaagaaaaggctatagga
11581 acccaaggct cctccctacc catggagaaa tttattagta tgttactcatatgctgcttt
11641 tctcatttta cccctaccac caccccgttg ccatccgcac tgtaagtcaggataggaaaa
11701 tgctggtgtt acagtcttcc tggggaatat ggagctgaag tggagtaaaagcagttgact
11761 tcattcctac ttttttcttt tttttctttt tttttttttt tgagacagagttttgctgtg
11821 tcaccaaggc tggagtgcag tgacgtgatc tcggctcact gcaacctccatcttccaggt
11881 tcaagcaatt ctcctgcctc agtctcccga gtagctggga ctgtaggtgtgcaccaccat
11941 gccaggctaa tttttgtatt tgttgtaggg acgagctttc accatgttggccaggctggt
12001 cttgaactcc tggcttcaag tgatctgccc acctcggctt cccaacattcttatattttt
12061 ataggccttt ccacagattt cagctcttgt atgacttagc ccagttccagaactggtaat
12121 cctaggtagg gtacaggtta tcacctctga tttcgggtaa aagggatttatttatttatt
12181 tgtttattta tttatatttt tgagacagag tctcgctctg tcacccaggctggagtgcaa
12241 tggtgccatc tcggctcact gcaacctctc cctctggggt tcaagcaattctcctgcctc
12301 agcctgctga gtagctggga ttacaggcgc gtgccaccac acccggctaatttttgcatt
12361 tttagtagag acggggtttc accatgttgc tcagggtggt ctcgaatttctgaccctgtg
12421 atctgcctgc ctcggcctcc caaagtgctg ggattacagg catgagccactgcgtccggc
12481 ctgtttttac ttttttttaa tgccattcag atctgtttaa atatgtgggttctgtgagat
12541 aatttagaat cccaaggtta cagatgaggt gaaagatcct agaccatgcatcaaaaaact
12601 tgagtttctc atttgtgaaa gaaggataag agaaacacct attttgtctgggtgcagtgg
12661 ctcatgccta taatcccagc atttggggag gccaaggtgg gtggatcacggaggtcaggt
12721 gttcaagacc agactggcca acatggcaaa acaccatctc tactaaaaatacaaaagtta
12781 gctgggcgtg gtggcacgtg cgtgtaattc cagctattcg ggaggctgaggcacgagaat
12841 tgcttgaacc tgggaggtgc gggttgcagt gaactgagat cgcagcaccactgtgctcca
12901 gcctgagtga tggagtgagg ccaggtcttg ttgtaggatc aaatgagataacacctgaaa
12961 gaactttgta aattgtatag cacgtacaaa caagaaggga cctcttcacaagcagaggaa
13021 gggtggtcct gtggaaaaaa acgggaattg ggagtgagag acctcaacatttgatctctg
13081 tgaacctcag ttttttaatc tataaaatgg ggaaatgtta atggtacttaatatttggag
13141 cttttgagtc cattagatca ggtaggattg ttcgttattt tttttttttaggaagactag
13201 aaatatgttg ctcccttttt ctcccccact caagcttgat ggtgggaattggccctggag
13261 ctgtttacta tcagttcctg tccagcttca ctaaatttgg tctggggtcacatcttagct
13321 gcggactgtg gggttttgtg gtcccttctc gacttggccc agctccacctgaatcctgtt
13381 gttgtcaaat tgctgtaata ggatccagtt gatggacaga ctatccaatgaatccattat
13441 gttggtggtg gagctggtgc aaagagctcc agagcagctg ctggcactgacccccctcca
13501 ccaggcagcc ctggcagaga gggcactaca aaacctggta agagtccaccctaccagact
13561 cagatttgct gccctgggca attcttgctc ctcagacaat gctctctgactgtcccccaa
13621 ccctctactt cttgctttct tgctgccaaa cagattcctg tctacaaggcctggcccctg
13681 ttttgcctct gggttctgtt ccttgataat atgcttcacg ttacttgtccatacctcttg
13741 gagtccgaga aatctcttgg agtccacctc tcagtctttc tgcctgctcctatctgggct
13801 cattgcttaa ggaagtgaac aaaggtagtg agcatcatag ggtgctgagctgggagcagg
13861 agggagggaa ggttaggggg cttggtgtct tgatcaaggt gtctggtattctgagtcaga
13921 agtgcattgt ccaagttctg atgctcttct ccaggctcca aaggagactccagtctcagg
13981 ggaagtgctg gagaccttag gccctttggt tggattcctg gggacagagagcacacgaca
14041 gatcccccta cagatcctgc tgtcccatct cagtcagctg caaggcttctgcctaggaga
14101 gacatttgcc acagagctgg gatggctgct attgcaggag tctgttcttgggtatggacc
14161 ttcgagaact tcagattcta actcattcta tacccagtcc ctcagccaccatcatcagtg
14221 gcagcctgtt ccatattctt aaggtcccct ggagccctgt gtccgaaatcctagcatgtc
14281 ctcttttccc cttccttttc ctcacagttc cctcagctcc ccagcccccgattttcttcc
14341 tgtccccagg aaaccagagt tgtggagcca ggatgaagta gagcaagctggacgcctagt
14401 attcactctg tctactgagg caatttcctt gatccccagg gtgagatgaaggaagaaggg
14461 aagggagtaa atgcatagag gggactggtg agctggttat ggggacccgtggccaaagag
14521 ggcaaaggat atgaagccta gatctggggg gagactgcaa aacagagacaggactttgga
14581 cttagagcta tagcagcagg tcctgatctg tccagatctc cccactctccttctaccttc
14641 tcatgcagga ggccttgggt ccagagaccc tggagcggct tctagaaaagcagcagagct
14701 gggagcagag cagagttgga cagctgtgta gggagccaca gcttgctgccaagaaagcag
14761 ccctggtagc aggggtggtg cgaccagctg ctgaggatct tccaggtgaaactacccaaa
14821 tacttatatg tccagcagga tgtacaggga gtatcaaacg gtctgggttctacatgtgct
14881 cttccctggg actgggtttt ctaatttata aagcaaagag tttagagggatgatcttcaa
14941 gcctcttgta gttctagaat tctgtagttc tgggagtttg taaactattaagttttcttt
15001 tagcccagaa cttccatttt cctgctctct cgtgtctgct ctagactcagctctagctcg
15061 gctaagtgtg gagctctctg ctggggagat ccctagaagc tttgaaggagacattgtgag
15121 gctggagaac tgggttcaaa ttcagtgcta ccattaaatc tctgaataacatcctcagtc
15181 ttccatctat aaaagtcttg gcatctccaa tcacttcttg ttctattatctcctaagccc
15241 tatacatatt actctgtaat actcctttga tccctatttc tcacagtgctctatcctcca
15301 aaggttggaa gactcactct atctacagat atctctctgg gcatattttattactgcgct
15361 gacctcctgg ccctgccttc ccccttcaga acctgtgcca aattgtgcagatgtacgagg
15421 gacattccca gcagcctggt ctgcaaccca gattgcagag atggagctctcagactttga
15481 ggactgcctg acattatttg caggagaccc aggacttggg cctgaggaactgcgggcagc
15541 catgggcaaa gcaaaacagg ttagggatgg agagccaact ggggttggccatgaggaagc
15601 tatttgggtg tgatgtagga cacaaagaga atggagagtt ggatgagaggtgggggaagc
15661 aagagataga agagttagaa gatttgggtc acaagtagga ggtgaagggagataaatatt
15721 gaggaaagag agctagtata atgaatagag ggacgaaagc agtggttaccaaattttaat
15781 gcatatcacg atcatcaagg gaacagattt ttttctttat ttttttttctttcttaaaaa
15841 aataatggca tgcttcggct gggtgcagcg gctcacgcct ataatctcagaactttggga
15901 ggccaaggcg ggcagatcac gaggtcagga gatcaagacc atcctgtctaacacggcgaa
15961 acacggtctc tactaaaaat acaaaaaagt tagccgggca tggtggtgcacacttgttgt
16021 cccagctact tgggaggctg aggcaggaga atggcgtgaa cctgggagggggagcttgca
16081 gtgagccgaa gtcaagccaa tgcactccat cctgggtgac agagcaagactccatctcaa
16141 aaaaaaaaaa aaaaaaaaaa ggcatgcttc atgaatttgc gtgttatccttgcacaggcg
16201 ccatgcaaat ctctgtatca ttccaatttt ttggggtatg tgctgctgaactgagcatgg
16261 gaacagtgcc agtgccagat taccatgctt cactgactta ataaaaacctttggggaggc
16321 tgggcgcagt gactcatgcc tgtaatcaca gcactttggg aggcggaggcaggtggattg
16381 cttgagccca ggagttagag accagactgg gcaacatggt gaaaccctgtctctactaaa
16441 aatagaaaaa acattagctg ggtgtggcgg cacatgcctg taatcccagctactcaggag
16501 gctggggtag gagaatccca tgagtgcagg aggtggaggg tgcaatgtgccaagatcgca
16561 ccactgccct ccagcctggg tgtcagagca agaccctgtc tcataaattaaaaaataagc
16621 ctctggggga aagagtctag acatctgcat ctcctttttt tttttttttttttttttttg
16681 agacagagtc tcactctgtc acccagcatc caggctggag tgcagtggtgtgatcttggc
16741 tcactgtaac ctctacatcc tgggttcaaa cgatcctcct gcctcagcctctcaagtagc
16801 tgggactaca ggtgcaccac acctggctaa tttttgtatc tttggtagagatggggtttc
16861 actatgttgc ccaggatggt ctcgaacttc tgggctcaag caatcctcccacctcagcct
16921 cccaaagtgc tgggattaca gctgttagcc actgtgctgg gccctaggcatctgttttaa
16981 taagcgtctc tgtgtctgat gcacataaaa gtgtggaact catggactagagttagtttg
17041 ctcttctttt ccactgattg taatgtcttt caaaacacct tagaggaactgtaaggcaac
17101 ggtctcattt tatagtggag gaaactaaag aaaaggcaaa tgatttacctagagttatac
17161 agctaagggc agaggcaaga cttaaaaccc agcagtatga ctcccaatccactgcttttc
17221 cactcacatt gttcctgtct ttctcctagt tgtggggtcc cccccggggatttcgtcctg
17281 agcagatcct gcagcttggt aggctcttaa taggtctagg agatcgggaactacaggagc
17341 tgatcctagt ggactgggga gtgctgagca ccctggggca gatagatggctggagcacca
17401 ctcaggtaac acttttcctc ctccctacgg cttcccaaac acccatcccacagacccagc
17461 cctatagatc atctaaagcc caaggaattt ttttcctgtg accctacctggtccttcttt
17521 ctatcttttg ttgatacccc atactagtga ccttcaggac tctgatttattcactctgag
17581 gccctggaca cataatactg tctcctacct cttttcctgg aggcttcctctttttctttc
17641 cttttctttt ctgagtcctc agccttcccc atgactcctt aggtcttaatagtaacagaa
17701 tataacccag taacacctat cacttccctg tccattaatt ctccataactttcctccttc
17761 ccctcttctc ccacccccca ccccagctcc gcattgtggt ctccagtttcctacggcaga
17821 gtggtcggca tgtgagccac ctggacttcg ttcatctgac agcgctgggttatactctct
17881 gtggactgcg gccagaggag ctccagcaca tcagcagttg ggagttcaggtcatttgtga
17941 aggggctgag ggtggtggtg ctgaggtaaa ggtggactta ctggggaaagaaggatcatg
18001 aaggtctggt cccatggagg aagggaactc atttgaagcc atctcttcctttgtctcatg
18061 accacagccc ctttcactga agccgaattc ttcttccttc cttcctactgttctacagcc
18121 aagcagctct cttcctcggc accctgcatc tccagtgctc tgaggaacaactggaggttc
18181 tggcccacct acttgtactg cctggtgggt ttggcccaat cagtaactgggggcctgaga
18241 tcttcactga aattggcacc atagcaggtg gggagctggg ccactgctggtgcaagttgg
18301 tttggtttct ataccatggg tggactggat ggaagactgc cctgcaattcttaaggtggg
18361 ggcctgaggg tgtttaaata aggggctaga gacatattgg ggaaggtctatgatagggca
18421 ctttgggagt agttagagaa ggtctatagg tttgaagaga gggaaggtcagtctaagaca
18481 atgtttggat gccacttgct tcaacagctg ggatcccaga cctggctctttcagcactgc
18541 tgcggggaca gatccagggc gttactcctc ttgccatttc tgtcatccctcctcctaaat
18601 ttgctgtaag tattaatgga ctggggtgac cacaggagag ccagggcccaatggggacta
18661 catgcatgca ctgattccta cccctgccct caggtggtgt ttagtcccatccaactatct
18721 agtctcacca gtgctcaggc tgtggctgtc actcctgagc aaatggcctttctgagtcct
18781 gagcagcgac gagcagttgc atgggcccaa catgagggaa aggagagcccagaacagcaa
18841 ggtgagttcc cagctgcaca gcttgatcct ccatctcctg acccagaatcaaacccctaa
18901 tttggtgctg tctggctctt agagtgcacc cagggagatc cctggagtgaaggagtctac
18961 aggcagagcg ctaatttcca agtatcaatg ctcctggaga gctgagttgtgatattactc
19021 ccattccctg tctattatag gtcgaagtac agcctggggc ctccaggactggtcacgacc
19081 ttcctggtcc ctggtattga ctatcagctt ccttggccac ctgctatgagcctgtctcta
19141 cagtagaagg agattgtggg gagagaaatc ttaagtcata atgaataaagtgcaaacaga
19201 agtgcatcct gattattttc agaagctgat gaggaata
人STRC假基因的核苷酸序列示于SEQ ID NO:38。
人硬纤毛蛋白假基因1(STRCP1)(SEQ ID NO:38)
1 gccctgccct cacctggcta tcccacacag gtgagaataa ccagaactca cctccggtac
61 cagtgttcac ttggaaacat ggctctcagc ctctggcccc tgctgctgct gctgctgctg
121 ctgctgctgc tgtcctttgc aggtaagaag aacagtgagc agaactgggg atgaggagga
181 gggtggctgg aaaaagactt taagaatatg gaggtgaacc tgttagatag aaggacaaag
241 gagagaggca gagacttgtg caaaagggaa aaatgagggt taagaaaagc aggccaagac
301 ttactgtagg ccagtgaaag gggttcagct caccatcccc tcacctcatc tttagatcca
361 ggtagggaac tgtgctcagg ggcagggttg agtttgggct ctgtgttcct ctccttcagt
421 gacctctggt ttctctcctt acagtgactc tggcccctac tgggcctcat tccctggacc
481 ctggtctctc cttcctgaag tcattgctct ccactctgga ccaggctccc cagggctccc
541 tgagccgctc acggttcttt acattcctgg ccaacatttc ttcttccttt gagcctggga
601 gaatggggga aggaccagta ggagagcccc cacctctcca gccgcctgct ctgcggctcc
661 atgattttct agtgacactg agaggtagcc ccgactggga gccaatgcta gggctgctag
721 gggatatgct ggcactgctg ggacaggagc agactccccg agatttcctg gtgcaccagg
781 caggggtgct gggtggactt gtggaggtgc tgctgggagc cttagttcct gggggccccc
841 ctaccccaac tcagccccca tgcacccgtg atgggccgtc tgactgtgtc ctggctgctg
901 actggttgcc ttctctgctg ctgttgttag agggcacacg ctggcaagct ctggtgcagg
961 tgcagcccag tgtggacccc accaatgcca caggcctcga tgggagggag gcagctcctc
1021 actttttgca gggtctgttg ggtttgctta ccccaacagg ggagctaggctccaaggagg
1081 ctctttgggg cggtctgcta cgcacagtgg gggcccccct ctatgctgcctttcaggagg
1141 ggctgctccg tgtcactcac tccctgcagg atgaggtctt ctccattttggggcagccag
1201 agcctgatac caatgggcag tgccagggag gtgagtgtgg ccagggctgggactgggatg
1261 tggcagggca aggaaagtga aattggggta gttttcttcc ttactctttccctcctaggt
1321 aaccttcaac agctgctctt atggtaagta acaggagacc agttctgagggattgggcct
1381 ggaaaatctg gaggtgaaga gctgaagacc tcagcctcta gagaggaaaactgatgggag
1441 gagtgtagtt tagtggtttt ggggtgtgac tgtctgggtt ggtgtcccagctccacctct
1501 tcctagccat atgaccttga gcaggttaca tagtctttct atacctcagtttccccattt
1561 ataaaatgag aatgataata ttagttacca cagagttgtt gcacccggttaaatgagttg
1621 atactgtgta tgcaaacgac ttaaaaccgt gctggcacat agcgcttaataatgttagct
1681 agtaaagatg ggatttggaa aataaggaca cagctggatt cctctacccccttactactt
1741 cagtacaaca atgccagaca gtagttagac atattgagtt gctgagcagatttcctaaca
1801 tgaggcccgc tgagggttgt gtttaagcta tctaaaagca tatgaagaaaggagacagaa
1861 gggggccagg tggacagaaa gaattccaac tggggcttct cctaggtgattttggacctt
1921 ggcagggcag ctttctcttt tttgccccgt tgcagcattt caaccagtaacgcctaaact
1981 ctcagggacc tcgcttgtag aaaagcctat gcttgccatg ccccttgagggctctgagtc
2041 agggtcagaa tcttcagctg gaggaaatgt gaactgacca gatcctgcctgctcctccct
2101 ctgcacccag gggcgtccgg cacaaccttt cctgggatgt ccaggcgctgggctttctgt
2161 ctggatcacc acccccaccc cctgccctcc ttcactgcct gagcacgggcgtgcctctgc
2221 ccagagcttc tcagccgtca gcccacatca gcccacgcca acggcgagccatcactgtgg
2281 aggccctctg tgagaaccac ttaggcccag caccacccta cagcatttccaacttctcca
2341 tccacttgct ctgccagcac accaagcctg ccactccaca gccccatcccagcaccactg
2401 ccatctgcca gacagctgtg tggtatgcag tgtcctgggc accaggtgcccaaggctggc
2461 tacaggcctg ccacgaccag tttcctgatg agtttttgga tgcgatctgcagtaacctct
2521 ccttttcagc cctgtctggc tccaaccgcc gcctggtgaa gcggctctgtgctggcctgc
2581 tcccaccccc taccagctgc cctgaaggcc tgccccctgt tcccctcaccccagacatct
2641 tttggggctg cttcttggag aatgagactc tgtgggctga gcgactgtgtggggaggcaa
2701 gtctacaggc tgtgcccccc agcaaccagg cttgggtcca gcatgtgtgccagggcccca
2761 ccccagatgt cactgcctcc ccaccatgcc acattggacc ctgtggggaacgctgcccgg
2821 atgggggcag cttcctggtg atggtctgtg ccaatgacac catgtatgaggtcctggtgc
2881 ccttctggcc ttggctagca ggccaatgca ggataagtcg tgggggcaatgacacttgct
2941 tcctagaagg gctgctgggc ccccttctgc cctctctgcc accactgggaccatccccac
3001 tctgtctgac ccctggcccc ttcctccttg gcatgctatc ccagttgccacgctgtcagt
3061 cctctgtccc agctcttgct caccccacac gcctacacta tctcctccgcctgctgacct
3121 tcctcttggg tccaggggct gggggcgctg aggcccaggg gatgctgggtcgggccctac
3181 tgctctccag tctcccagac aactgctcct tctgggatgc ctttcgcccagagggccggc
3241 gcagtgtgct acggacgatt ggggaatacc tggaacaaga tgaggagcagccaaccccat
3301 caggctttga acccactgtc aaccccagct ctggtataag caagatggagctgctggcct
3361 gctttagtgt gagtgctctg ccagagggaa agctcctaga acagtgagaaggccctccag
3421 gggaattcct cgaatactca gaggcagtag tgtggggtag tagttgaagcacacagctct
3481 agagtcagac aggcttggat tcatatcttg gttctgtgac cagccttgaatgagttattt
3541 aacttctctg agcaatattt ttctcgtctc atttataaac tagggatgataatggtatat
3601 gagataatac atgctgtggg cttagcacag tgcatgatac acaaacatgcaataaatatt
3661 accttgttat tcttttgggc tctttgactc tctcactttc tgcaccagaaagaaaaagga
3721 tcaagttaga ggactctaaa tttttcccct agagagtgag aattggaggctggcagaata
3781 caggaagata aggtaggaat gagaaagatt cagggacact accaatcagaagactttggt
3841 tctaggttca actgtgccac aaattagtgt gatcttaggc aagcaatttcatttagtttt
3901 tctgggcttc agtttttagt ctgtagaatg gaggggtgag aatatgttaaacaccataat
3961 taattcactg agtgcctatt atatgcaagg cactttgcta ggttctgtaggatatataaa
4021 gatttcttac tccatgttgg ggccaccttt ttcaaaccct gggcccagtaaaatggaatt
4081 agatagtctc atagtatttg gttcaggtct acaagtatta attgagccaactatggacct
4141 ggcatgggag agggtacaag agaaattaga gatatgatcc cggacctaaaagagcttaat
4201 atctgaagaa tcacacttga gatgatggac aagcatccca gcaagtggagttggaatgcc
4261 tgggggagct gcaggagaga cagagaagac agctctgttg gcatattgtctttcttccca
4321 ccagcctgtg ctgtgggatc tgctccagag ggaaaagagt gtttgggccctgcagattct
4381 agtgcaggta acaggtggag ggcacatggg tgggctgggt gacagccatggctggaggtc
4441 cctgccccgt gaggtgaggc catacccacc atgacctcct attcgcaggcgtacctgcat
4501 atgcccccag aaaacctcca gcagctggtg ctttcagcag agagggaggctgcacagggc
4561 ttcctgacac tcatgctgca ggggaagctg caggggaagc tgcaggtgagcactgagaaa
4621 ggggagcaag ggcacctgga gcctagtgtt cagagggctt gctttagtgggaggaggaac
4681 tccagagagg aaatggcagg gatactgagc atctccagag gcagaatccattcctgtgcc
4741 cctacaggta ccaccatccg aggagcaggc cctgggtcgc ctgacagccctgctgctcca
4801 gcggtaccca cgcctcacct cccagctctt cattgacctg tcaccactcatccctttctt
4861 ggctgtctct gacctgatgc gcttcccacc atccctgtta gccaacgacagtgtgtaagg
4921 ttcttgcact actcctcctg ctcctgtcac ggtcaggcca accgcatccacctggagcag
4981 ccccttccgg agctcctctc tgtttttttc tttcatgcca gataggcaatgtgccaacat
5041 cgtagcaagg tttgagagag gcacatctca cgcctgagtg tgaaaacccaatcattatgc
5101 taatgaacta caaaaggatc agagagctcc tctctattaa aaccagggagaggatgggcg
5161 tggtggctca tgcctgtaat cccagcacgt tgggagcccg aggcaggtggatcactaggt
5221 ccgcctagtg agttcgagac cagcctggcc aatatggtga aaccctgtctctattaaact
5281 acaaaaatta gccaggcatg gtggtgggcg cttgtagtcc cagttactctggaggctgag
5341 gcaggaggat agcttgaacc tgggaggcag aggttgcagt gagccaagatcgtgccactg
5401 cactccagcc tgggtgacag agcgagactc cgtcttaaaa aaaacaaaaaacaaaacaaa
5461 acaaaaaaac agggagagtc tccttcctat ctagacagca gggctacagagggtcagagg
5521 aaaacagttt ggaggaagac aaagggttaa gacccatgac tcctcgcagcctggctgcca
5581 tccgggatta cagcccagga atgaggcctg aacagaagga ggctctggcaaagcgactgc
5641 tggcccctga actgtttggg gaagtgcctg cctggcccca ggagctgctgtgggcagtgc
5701 tgcccctgct cccccacctc cctctggaga actttttgca gctcagccctcaccaggtat
5761 gagaatcatc ttctttactt gactggccca tcttctgcta gtggggacaaagagtcaatg
5821 gcatgtctct cagtggcccc tccctgcaag aaccctatag tgaccccagtgcgagctaac
5881 cttccccatc tcagatccag gccctggagg atagctggcc agcagcaggtctggggccag
5941 ggcatgcccg ccatgtgctg cgcagcctgg taaaccagag tgtccaggatggtgaggagc
6001 aggtacgcag gtgagttgtt gtgggatcag taaccaaggc aagagtggaagaggtagaga
6061 gaggaaggca cagctgtcac gctgggtcgg tgttctagga agaaaggggcaagagagtag
6121 gcagtggcct caggcagcat agagttccag gagagaggtc tatagatggtgcccctgtgt
6181 agtggtgtag tgtcagagtg cccagtgtat gtacccatac catctgctgccaggcctgcc
6241 ttagtgctag tcttggggac cacacaaagg tcagcttcat gccctcctcaggcttgggcc
6301 cctcgcctgt ttcctgagcc ctgaggagct gcagagccta gtgcccctgagtgatccaac
6361 ggggccagta gaacgggggc tgctggaatg tgcagccaat gggaccctcagcccagaagg
6421 acgggtgagc ccctcagcac aagcctacaa gactttaggc ttcccctgggtctgtgtgga
6481 tggctttccc attgtgtcaa cttgagcaca gtggtgccag cccccatcccacttttgcaa
6541 cctccattcc ttactccatg gccattctta cctgttacca cctcttcctggcccttctct
6601 atctggtctg tagcacccca aacataccct ttgccatttt gaacctaatctactccagtc
6661 caatccctag ttccaaaccc tagcccaggc cctgggaaat tcagatgtgggattagagag
6721 gaagttcaag gttcatctgt cttttctctc cagtcctaaa ccttctttggttacaggtgg
6781 catatgaact tctgggtgtg ttgcgctcat ctggaggagc ggtgctgagcccccgggagc
6841 tgcgggtctg ggcccctctc ttctctcagc tgggcctccg cttccttcaggagctgtcag
6901 agccccagct tagagccatg cttcctgtcc tgcagggaac tagtgttacacctgctcagg
6961 tttgcctgtc tcactccctg gcatgtaccc tccatccccg cttgagccccagtcaagaga
7021 atcccattca gggataaaag cagcccctcc tttccctggg tgaacagtagaggtaaactc
7081 tgtctgcagg aggacgcctt cattcccttt cctcagatca agaagggacctgagtcactg
7141 aggatggtta ctggggatgg ttaagaggca gcgggaagtt ttggagggtttgccttagga
7201 acccacttag gacctggctg ctgggtcctg agagctgttg ttttcggtcccatcccaaca
7261 caggctgtcc tgctgcttgg acggctcctt cctaggcacg atgtgagtagcagcaacttc
7321 tcagcctccc gccagaggtc tctatcctct tttaacctgg ctcctgcatctgcccctcct
7381 ctctctccgc tcccctcata cttactgcct tgctgcattg tgattgttgtcttccccaac
7441 acccttccct tcttcttcag gcctcttgtc tctcttgctc tttagctatccctggaggaa
7501 ctctgctcct tgcaccttct gctaccaggc ctcagccccc agacactccaggccatccct
7561 aggcgagtcc tggtcggggc ttgttcctgc ctggcccctg aactgtcacgcctctcagcc
7621 tgccagaccg cagcactgct gcagaccttt cgggtatgag agtggcaaggaggatgagat
7681 aatcagggat accggctctt tctggttggg aggaaggcat cttccctgaggccagggaag
7741 gcctttcata cctccccact tacacacaca cacacacaca cacacacacaaccaattctc
7801 atgcaggtta aagatggtgt taaaaatatg ggtacaacag gtgctggtccagctgtgtgc
7861 atccctggtc aggtaagtgt gagatctccc aactgagctc ctctccccattctggggcag
7921 tttcatatgg ctggtgctac ctcccacact accctgcagt ggccctgagagttctggtta
7981 gctctgtgcc cattagcagc cctccccagt gccagatgca ggacagcatgatccactcac
8041 attgtcctag actaatgtca aagctggaag ggcctgagaa atcttccaggccacccaccc
8101 tgctttcaga tgaaaagacc aaggctggga gaagctaagg gactttgtttgcctggtgcc
8161 taactagcag caacacttga ccacagcagc ctgcagtgtg aggctcttaggcgtttattg
8221 ctacagtggc aaatgccatt ccacttctgt cctagctttg gtccctttccacccccatgg
8281 ttccttttct ctgagtgcta agtacagact ctctcaccta tcactacactgctataccca
8341 tcaccgccag cagcctattc ccaccacctg gccagactgc ctgcttcccctgctcccatt
8401 aaagctgcta caactggatt ccttggctct tctggcaaat cgaagacgctactgggagct
8461 gccctggtct gagcagcagg taattctccc cacttaattt cagaacttcctccctcaatg
8521 tagtctacct tctttaccta tcccttagcc ctatttggcc agcttatccctactatcctt
8581 tatttgattg tttgagatac agtctcactc tgttgcccag gctgcagtgcagtggcatga
8641 tcagagttcg ctgtaacctc aaactcatga gctcaggcaa tctttctgcctcagcctcct
8701 gaatagctag gatgacaggt ggttaccacc atgcctggct aatttttaaatttttttttt
8761 gttttttgag atgaagtctt gctctgtcac ccaggcttga gtacagtggcacaagcttgg
8821 ctcactgcaa cctctgtctc ccgggttcaa gcgattctcc tgcctcagcctcccgagtag
8881 ctgggactac aggcactccc cacaatgccc ggctaatttt ttttttgttttagtagagac
8941 agggtttcac catattggcc aggctggtct cgaactgctg accttgtgatctgcctgcct
9001 ctgcctctca aagtgctggg attacaggtg tgagccacca tgcccggccaatttttaaat
9061 tttttgtaga gacagacaat acaaaaatgt ggacactatg tggagacactatgttgaggt
9121 actatgctgt ccagattggt cttgaactcc tggcctcaag caatcctcctgccttggcct
9181 cccaaagtgc tgggattaca gacctgagcc actgcaccca gccccctagtatcccttata
9241 atgtgacttg cttttctttt tctttctcct tcccttttct ttcatttctttctcactctc
9301 gagagaagag tgggcatctg ggagagtggg aggctggtgg gtcccacagagtgaggaggc
9361 aggactgggt ccaaggcagt cctgcctctc cactctaggg ggtatccttggacagtgtct
9421 cttctgggaa ggggctcgtc tttctttctc ttgtaggcac agtttctctggaagaagatg
9481 caagtaccca ccaacctgac cctcaggaat ctacagtgag taacttgtgttgagcagtgc
9541 gctgaattcg accaacattt ttttgagtgc ttactatgtg ccaggcaccatatgatatgg
9601 aatgggggat atagggatga atgatgcata gtccctgcct cgtggacgttctcctagcac
9661 ctccctttgc cctcctttcc ttccacagtg ccatgcctat cctgactagagccaaaggac
9721 tcagaaaacc tggattcagg ttccagtcct gtcacctact tgtcctcttgggcaagtcat
9781 ttaacgtccc tgtgtcagtt ttcccttctt taaatgagaa ttacaatggcaccagcctca
9841 taggtagtta ctgtgaagat taaatgaggt aggtcatgta agatatttaacacagtgttt
9901 ggtccattgt aaagttccag tagtcatttg ctactgttag tttacttcaggatgacttca
9961 gaggcactgg ccaagcaaga ataaatagga ataagaaggt atcactttacttatacccac
10021 attagaagaa caatgggctt cagaatcttt tttttttttt ttttcgagacagtcttgctc
10081 tgttgcccag gctggagtgc agtggcgcga tttcggctca ctgcaacctctgcctcccag
10141 gttcaagcga ttctcctgtc tcagcctctg gagtagctgg gattacaggaatgtgccacc
10201 atacccagct aatttttgta tttttagtag agatggggtt tcaccattttggccaggctg
10261 gtctcaaact cctgacctca ggtgatccac ccgcctcagc ctcccaagggcttcagaatc
10321 taagacatgt ctctagtttc agtttaccac atttctagca gaatgatgttgggaatgtca
10381 cctgacttcc ataaatcctt attttctcct ctgataaaca gcagtgatgttatggggagc
10441 tgatgagata tctatgtaaa aacatttctc aaaccataaa ttacggtggatgaacatctg
10501 tacttgtgtt gagagtactg atatcaagga gcaaacaggc tgttgtatgtgttgaatgag
10561 cctctcccca ctcacacacc cacagggctc tgggcaccct ggcaggaggcatgtcctgtg
10621 agtttctgca gcagatcaac tccatggtag acttccttga agtggtgcacatgatctatc
10681 agctgcccac tagagttcga gggagcctgg tgagagggga tgcctggactttagtgggag
10741 cagggaggct gggaccctag gtatagaacc cagctcctat gttctgctctggcctcactc
10801 tgcttcccta cagagggcct gtatctgggc agagctacag cggaggatggcaatgccaga
10861 accagaatgg acaactgtag ggccagaact gaacgggctg gatagcaagctactcctgga
10921 cttaccgtaa gtactgcagc tagagatatt ggcccctcag aaagctcaatctggggtgaa
10981 gatctgccct tagggaatgc cctggaggag gtagtttttc tgtctggtagttccctgaca
11041 taatttatag cccaaagcag aggattttat tcaaagttgc tctatgtattgactggttcc
11101 cagaatatgc tccagcacag ggcagctgag ggtggcaaca ctgtattgaagcctgccaag
11161 taatcttaca ataacctagt ccacattaat tgagattgag acagagcatctgaagtgagg
11221 gaggcaatgc tccaaatctg ccccagagga ttgtagtttg ctcagggcactgtgttctta
11281 gtgcattcag aggagtggat cgagagaaaa atatatgaaa aatgtgataaataccttcaa
11341 atacctgagg ggctatcaag tagaaattag attgtcatat ttatgagtggccccattggg
11401 caagactaag agtagttaac ggagatcaga tttttacata gtataagaaaaactaaggta
11461 gtgagttcct ggtccttgga gctgttcgag cctaagccag atggccccatggcaggaatg
11521 ttgtagagca cgttcatata caggttgtgg gaagaaaagg ctataggaacccaaggctcc
11581 tccctaccca tggagaaatt tattagtatg ttactcatat gctgcttttctcattttacc
11641 cctaccacca ccccgttgcc atccgcactg taagtcagga taggaaaatgctggtgttac
11701 agtcttcctg gggaatatgg agctgaagtg gagtaaaagc agttgacttcattcttactt
11761 ttttcttttt cttttttttt ttttttttga gacagagttt tgctgtgtcaccaaggctgg
11821 agtgcagtga cgtgatctcg gctcactgca acctccatct tccaggttcaagcaattctc
11881 ctgcctcagt ctcccgagta gctgggactg taggtgtgca ccaccatgccaggctaattt
11941 ttgtatttgt tgtagggacg agctttcacc atgttggcca ggctggtcttgaactcctgg
12001 cttcaagtga tctgcccacc tcggcttccc aacattctta tatttttataggcctttcca
12061 cagatttcag ctcttgtatg acttagccca gttccagaac tggtaatcctaggtagggta
12121 caggttatca cctctgattt cgggtaaaag ggatttattt atttatttgtttatttattt
12181 atatttttga gacagagtct cgctctgtca cccaggctgg agtgcaatggtgccatctcg
12241 gctcactgca acctctccct ctggggttca agcacttctg cctcagcctcctgagtagct
12301 gggattacag gcgcgtgcca ccacacccgg ctaatttttg catttttagtagagacgggg
12361 tttcaccatg ttgctcaggg tggtctcgaa tttctgaccc tgtgatctgcctgcctcggc
12421 ctcccaaagt gctgggatta caggcatgag ccactgcgtc cggcctgtttttactttttt
12481 ttaatgccat tcagatctgt ttaaatatgt gggttctgtg agataatttagaatcccaag
12541 gttacagatg aggtgaaaga tcctagacca tgcatcaaaa aacttgagtttctcatttgt
12601 gaaagaagga taagagaaac acctattttg tctgggtgca gtggctcatgcctataatcc
12661 cagcatttgg ggaggccaag gtgggtggat cacggaggtc aggtgttcaagaccagactg
12721 gccaacatgg caaaacacca tctctactaa aaatacaaaa gttagctgggcgtggtggca
12781 cgtgcgtgta attccagcta ttcgggaggc tgaggcacga gaattgcttgaacctgggag
12841 gtgcgggttg cagtgaactg agatcgcagc accactgtgc tccagcctgagtgatggagt
12901 gaggccaggt cttgttgtag gatcaaatga gataacacct gaaagaactttgtaaattgt
12961 atagcacgta caaacaagaa gggacctctt cacaagcaga ggaagggtggtcctgtggaa
13021 aaaaacggga attgggagtg agagacctca acatttgatc tctgtgaacctcagtttttt
13081 aatctataaa atggggaaat gttaatggta cttaatattt ggagcttttgagtccattag
13141 atcaggtagg attgttcgtt attttttttt tttaggaaga ctagaaatatgttgctccct
13201 ttttctcccc cactcaagct tgatggtggg aattggccct ggagctgtttactgtcagtt
13261 cctgtccagc ttcactaaat ttggtctggg gtcacatctt agctggggactgtggggttc
13321 tgtggtccct tctcgacttg gcccagctcc acttgaatga tattgttgtcaaattgctat
13381 aatagaatcc agttgatgga cagactatcc aatgaatcca ttatgttggtggtggagctg
13441 gtgcaaagag ctccagagca gctgctggca ctgacccccc tccaccaggcagccctggca
13501 gagagggcac tacaaaacct ggtaagagtc caccctacca gactcagatttgctgccctg
13561 ggcaattctt gctcctcaga caatgctctc tgactgtcct ccaaccctctacttcttgct
13621 ttcttgctgc caaacaggtt cctgtctaca aggcctggcc cgttttgcctctgggttctg
13681 ttccttgata atatgcttca cgttacttgt ccatacctct tggagtccgagaaatctctt
13741 ggagtccacc tctcagtctt tctgcctgct cctatctggt ctcattgcttaagaaagtga
13801 acaaaggtag tgagcatcat agggtgctga gttgggagca ggagggagggaaggtcaggg
13861 ggcttggtgt cttgatcaag gtgtctggta ttctgagtca gaagtgcattgtccaagttc
13921 tgatgctctt ctccaggctc caaaggagac tccagtctca ggggaagtgctggagacctt
13981 aggccctttg gttggattcc tggggacaga gagcacacga cagatccccctacagatcct
14041 gctgtcccat ctcagtcagc tgtaaggctt ctgcctagga gagacatttgccacagagct
14101 gggatggctg ctattgcagg agtctgttct tgggtatgga tcttcgagaacttcagattc
14161 taactcattc tatacccagt ccctcagcca ccatcatcag tggcagcctgttccatattc
14221 ctaagggccc ttggagccct gtgtccgaaa tcctagcatg tcctcttttccccttccttt
14281 tcctcacagt tccctcagct ccccagcccc cgattttctt cctgtccccaggaaaccaga
14341 gttgtggagc caggatgaag tagagcaagc tggacgccta gtattcactctgtctactga
14401 ggcaatttcc ttgatcccca gggtgagatg aaggaagaag ggaagggagtaaatgcatag
14461 aggggactgg tgagctggtt atggggaccc gtggccaacg agggcaaaggatatgaagcc
14521 tagatctggg gggatactgc gaaacagaga caggactttg gacttatagctatagcagca
14581 ggtcctgatc tgtccagatc tccccactct ccttctacct tctcatgcaggaggccttgg
14641 gtccagagac cctggagcgg cttctagaaa agcagcagag ctgggagcagagcagagttg
14701 gacagctgtg tagggggcca cagcttgctg ccaagaaagc agccctggtagcaggggtgg
14761 tgcgaccagc tgctgaggat cttccaggtg aaactaccca aatacttatatgtccagcag
14821 gatgtacagg gagtatcaaa cggtctgggt tctacatgtg cttttctctgggactgggtt
14881 ttctaattta taaagcaaag agtttagagg gatgatcttc aagtctcgtctagttctaaa
14941 attctatagc tctgggagtg tgtaaactat taagttttcc tttagcccagaacttccatt
15001 ttcctgctgt cttgtctctt taaacagctg actcagctct agctcggctaagtgtggagc
15061 tctctgctgg ggagatccct cgaaggagac attgtgaggc tagagaactggtttcaaatt
15121 cagctctgcc atgaaatccc tgaccaacat cctcagtctt ccatctataaaatgagggac
15181 ttggcatctc caatcacttc ttgttcaatt cacttctaag ccctatacatcttaacctgt
15241 aatactccct cgatccctac ttcccacagt gctccatcct ccaaaggttggaagagtcat
15301 tccatctaca gatacctcct ggccctgcct tcccccttca gaacctgtgccaaattgtgc
15361 agatgtacga gggacattcc cagcagcctg ctctgcaacc cagattgctgagatggagct
15421 ctcagacttt aaggactgcc tgacactatt tgcaggagac ccaggacttgggcctgagga
15481 accacgggca gccatgggca aagcaaaatg ggtcagggac ggagagccaactgaggttgg
15541 ccatgaggaa gctgtgtggg tgtgatgtag gacacgaaga gaatagagagttggatgaga
15601 ggtgggggaa gcagaagata aaagagttag aagatttggg tcacaagtagaaggtgagga
15661 gagataaata ttgaggaaag agagctacta taatgaatag agggactaaagcagtgatta
15721 ccaaatttta atgcatatca caatcatcaa gggaacagat ttttttcttttttctttttt
15781 tttctttctt aaaaaataat ggcatacttc atgaatttgt gtgttatccttgcgcaggcg
15841 ccatgctaat ctctgtatca ttccaatttt tttttgtata tgtgctgctgaaccgagcac
15901 gggaacagtg ccaatgctgg attaccatgc tagactgact taataaaaacctttgcggag
15961 gctggacgga gtggctcgtg cctgtaatca cagcactttg ggaggctgaggcaggtggat
16021 tgcttgagcc caggagtttg agaccagact gggcaacatg gtgaagccctgtctctacta
16081 aaaatagaaa aaaaattagc tgggtgtggc ggcacatgcc tgtaatcccagctactcagg
16141 aggctggggt aggagaatcc cctgagcgca ggaggtggag ggtgcaatgagccaagatca
16201 caccactgca ctccagcctg ggtgtcagag caagaccctg tctcataaattaaaaaataa
16261 gcctctggga gaaagtctag acatctgcat ctgctttttt ttttttttttttttttgaga
16321 cacagtctca ctctgtcacc cagcatccag gctggagtgc ggtggtgtgatcttggctca
16381 ctgtaacctc tacatcctgg gctcaaacga tcctcctgcc tcagcctctcgagaagctgg
16441 gactacaggt gcacaccact acacctggct aatttttgta tttttggtagagatgaggtt
16501 tcgctgtgtt gcccaggatg gtcttgaact cctgggctca agcattcctcccacctcagc
16561 ctcccaaagt gctgggatta cagctgtgag ccactgtgct gggccccaggcatctgcatt
16621 ttaataagcg tctctgtgtc tgatgcacat aaaagtgtgg aactcatggactagagttag
16681 tttgctcttc ttttccactg attgtaatgt ctttcaaaac accttagaggaactgtaagg
16741 caacggtctc attttatagt ggaggaaacc aaagaaaagg caagtgacttgcctagagtt
16801 atacagctaa ggtcagaggc aagacttaaa acccagcatt ctgactcccaatctactggt
16861 tttccactca cattgttcct ctctttctcc tagttgtggg gtcccccccggggatttggt
16921 cctgagcaga tcctgcagct cggtagactc ttaataggtc tgggagatcaggaactacag
16981 gagctgatcc tagtggactg gggagtgctg agcaccctgg ggcagatagatggctggagc
17041 tccactcagg taacactttt actcctccct accgcttccc aaacacccatcccacagacc
17101 cagccctata gatcatctaa agcccaagga attttttcct gtgaccctacctggtcattc
17161 tttctgtctt ttgttaatat cccatactag tgaccttcag gactcttgatttattcactc
17221 tgaggccctg gacacataat actgtctcct acctcttttc ctggaggcttcctctttttc
17281 tttccttttc ttttctgagt cctcagcctt ccccatgact ccttaggtcttaatagtaac
17341 agaatataac ccagtaacac ctatcacttc cctgtccatt aattctccataactttcctc
17401 cttcccctct tctcccaccc cccaccccag ctccgcattg tggtctccagtttcctacgg
17461 cagagtggtc ggcatgtgag ccacctggac ttcgttcatc tgacagcgctgggttatact
17521 ctctgtggac tgcggccaga ggagctccag cacatcagca gttgggagtttaggtcattt
17581 gtgaaggggc tgagggtggt cgtgttcagg taaaggtgga cttgctggggaaaggaggat
17641 catgaagtta tagtcccatg gaggaaggga actcatttga agccatctcttcctttgtct
17701 catgaccaca gtccctttca ctgaagccga attcttcttc cttccttcccactgttctac
17761 agccaagcag ctctcttcct gggcaccctg catctgcagt gctctgaggaacaactggag
17821 tttctggccc acctctttgt actgcctggt gggtttggcc caatcagtaactgggggcct
17881 gagatcttca ctgaaattgg caccatagca ggtggggagc tgggccactgctggtgcaag
17941 ttggtttggt ttctatacca tgggtggact ggatggaaga ctgccctgcaattcttcagg
18001 tgtgggcctg agagggtgtt taaataaggg gctagagaca tattggggaaggtctatgat
18061 agggcacttt gggagtagtt agagaaggtc tataggtttg aagagagggaaggtcagtct
18121 aagacaatgt ttggatgcca cttgcttcaa cagctgggat cccagacctggctctttcag
18181 cactgctgcg gggacagatc cagggcgtta ctcctcttgc catttctgtcatccctcctc
18241 ctaaatttgc tgtaagtatt aatggactgg ggtgaccaca ggagagccagggcccaatgg
18301 ggactacatg catgcactga ttcctacccc tgccctcagg tggtgtttagtcccatccaa
18361 ctatctagtc tcgccagtgc tcaggctgtg gctgtcactc ctgagcaaatggcctttctg
18421 agtcctgagc agcgacgagc agttgcatgg gcccaacatg agggaaaggagagcccagaa
18481 cagcaaggtg agttcccagc tgcacagctt gatcctccat ctcctgacccagaatcaaac
18541 ccctaatttg gtgctgtctg gctcttagag tgcacccagg gagatccctggagtgaagga
18601 gtctacaggc agagcgctaa tttccaagta tcaatgctcc tggagagctgagttgtgata
18661 ttactcccat tccctgtcta ttataggtcg aagtacagcc tggggcctccaggactggtc
18721 acgaccttcc tggtccctgg tattgactat cagcttcctt ggccacctgctatgagcctg
18781 tctctacagt agaaggagat tgtggggaga gaaatcttaa gtcataatgaataaagtgca
18841 aacagaagtg catcctgatt attttcagaa gctgatgagg aata
Clarin 1(CLRN1)
CLRN1基因编码“clarin 1”(CLRN1)(一种在内耳的毛细胞(例如，内耳毛细胞、外耳毛细胞)和视网膜中表达的蛋白质)。
人CLRN1基因位于染色体3q25.1上。其包含7个外显子，涵盖约47千碱基(kb)(Vastinsalo等人(2011)Eur J Hum Genet 19(1):30-35；NCBI登录号NG_009168.1)。
CLRN1基因中的各种突变与III型Usher综合征(例如，IIIA型Usher综合征(MIM#606397))(参见，例如，Fields等人(2002)Am J Hum Genet 71:607-617和Joensuu等人(2001)Am J Hum Genet 69:673-684)和色素性视网膜炎(参见，例如，Khan等人(2011)Ophthalmology 118:1444-1448)相关联。主要在CLRN1的外显子3中发现了导致III型Usher综合征的突变。可通过产生CLRN1缺陷型小鼠来对III型Usher综合征耳聋进行建模(参见，例如，Geng等人(2017)Sci Rep 7(1):13480)。与III型Usher综合征相关联的示例性突变CLRN1包括：T528G、M120K、M44K、N48K和C40G。
与色素性视网膜炎相关联的示例性突变CLRN1包括L154W和P31L(参见，例如，Khan等人(2011)Ophthalmology 118:1444-1448).。
在患有听力损失的受试者中检测到的CLRN1基因中的其它示例性突变以及编码CLRN1的核酸的测序方法描述于例如Fields等人(2002)Am J Hum Genet 71:607-617、Joensuu等人(2001)Am J Hum Genet 69:673-684、Adato等人(2002)Europ J Hum Genet10:339-350、Aller等人(2004),Clin Genet 66:525-529中。检测基因中的突变的方法是本领域公知的。此类技术的非限制性实例包括：实时聚合酶链式反应(RT-PCR)、PCR、测序、Southern印迹和Northern印迹。
示例性人野生型CLRN1蛋白为或包括SEQ ID NO:39、SEQ ID NO:41、SEQ ID NO:43和SEQ ID NO:45的序列。编码野生型CLRN1蛋白的核苷酸序列的非限制性实例为或包括SEQID NO:40、SEQ ID NO:42、SEQ ID NO:44和SEQ ID NO:46。
在本文所述的任何组合物的一些实施方案中，所述CLRN1蛋白包含与SEQ ID NO:39具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，所述CLRN1蛋白包含与SEQ ID NO:41具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，所述CLRN1蛋白包含与SEQ ID NO:43具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，所述CLRN1蛋白包含与SEQ ID NO:45具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
人全长野生型CLRN1蛋白异型体D(SEQ ID NO:39)
MPSQQKKIIFCMAGVFSFACALGVVTALGTPLWIKATVLCKTGALLVNASGQELDKFMGEMQYGLFHGEGVRQCGLGARPFRFSFFPDLLKAIPVSIHVNVILFSAILIVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSFISVALWLPATRHQAQGSCGCLVMILFASEVKIHHLSEKIANYKEGTYVYKTQSEKYTTSFWVIFFCFFVHFLNGLLIRLAGFQFPFAKSKDAETTNVAADLMY
人野生型CLRN1异型体D cDNA(SEQ ID NO:40)
atgccaagccaacagaagaaaatcattttttgcatggccggagtgttcagttttgcatgtgccctcggagttgtgacagccttggggacaccgttgtggatcaaagccactgtcctctgcaaaacgggagctctgctcgtcaatgcctcagggcaggagctggacaagtttatgggtgaaatgcagtacgggcttttccacggagagggtgtgaggcagtgtgggttgggagcaaggccctttcggttctcattttttccagatttgctcaaagcaatcccagtgagcatccacgtcaatgtcattctcttctctgccatccttattgtgttaaccatggtggggacagccttcttcatgtacaatgcttttggaaaaccttttgaaactctgcatggtcccctagggctgtaccttttgagcttcatttcagttgccctttggctgccagctaccaggcaccaggctcaaggctcctgtggctgtcttgtcatgatattgtttgcctctgaagtgaaaatccatcacctctcagaaaaaattgcaaattataaagaagggacttatgtctacaaaacgcaaagtgaaaaatataccacctcattctgggtcattttcttttgcttttttgttcattttctgaatgggctcctaatacgacttgctggatttcagttcccttttgcaaaatctaaagacgcagaaacaactaatgtagctgcagatctaatgtactga
人全长野生型CLRN1蛋白异型体A(SEQ ID NO:41)
MPSQQKKIIFCMAGVFSFACALGVVTALGTPLWIKATVLCKTGALLVNASGQELDKFMGEMQYGLFHGEGVRQCGLGARPFRFSFFPDLLKAIPVSIHVNVILFSAILIVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSFISGSCGCLVMILFASEVKIHHLSEKIANYKEGTYVYKTQSEKYTTSFWVIFFCFFVHFLNGLLIRLAGFQFPFAKSKDAETTNVAADLMY
人野生型CLRN1异型体A cDNA(SEQ ID NO:42)
atgccaagccaacagaagaaaatcattttttgcatggccggagtgttcagttttgcatgtgccctcggagttgtgacagccttggggacaccgttgtggatcaaagccactgtcctctgcaaaacgggagctctgctcgtcaatgcctcagggcaggagctggacaagtttatgggtgaaatgcagtacgggcttttccacggagagggtgtgaggcagtgtgggttgggagcaaggccctttcggttctcattttttccagatttgctcaaagcaatcccagtgagcatccacgtcaatgtcattctcttctctgccatccttattgtgttaaccatggtggggacagccttcttcatgtacaatgcttttggaaaaccttttgaaactctgcatggtcccctagggctgtaccttttgagcttcatttcaggctcctgtggctgtcttgtcatgatattgtttgcctctgaagtgaaaatccatcacctctcagaaaaaattgcaaattataaagaagggacttatgtctacaaaacgcaaagtgaaaaatataccacctcattctgggtcattttcttttgcttttttgttcattttctgaatgggctcctaatacgacttgctggatttcagttcccttttgcaaaatctaaagacgcagaaacaactaatgtagctgcagatctaatgtactga
人全长野生型CLRN1蛋白异型体C(SEQ ID NO:43)
MQALQQQPVFPDLLKAIPVSIHVNVILFSAILIVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSFISGSCGCLVMILFASEVKIHHLSEKIANYKEGTYVY KTQSEKYTTSFWLTKGHS
人野生型CLRN1异型体C cDNA(SEQ ID NO:44)
atgcaggccctgcagcagcaaccagtttttccagatttgctcaaagcaatcccagtgagcatccacgtcaatgtcattctcttctctgccatccttattgtgttaaccatggtggggacagccttcttcatgtacaatgcttttggaaaaccttttgaaactctgcatggtcccctagggctgtaccttttgagcttcatttcaggctcctgtggctgtcttgtcatgatattgtttgcctctgaagtgaaaatccatcacctctcagaaaaaattgcaaattataaagaagggacttatgtctacaaaacgcaaagtgaaaaatataccacctcattctggctgactaaaggccacagctga
人全长野生型CLRN1蛋白异型体E(SEQ ID NO:45)
MPSQQKKIIFCMAGVFSFACALGVVTALGTPLWIKATVLCKTGALLVNASGQELDKFMGEMQYGLFHGEGVRQCGLGARPFRFSCYFLDPFMGLPTGVPHLLSLPCSTSCRREHTSERVQEPAGCFSAVRSKLHAGPAAATSFSRFAQSNPSEHPRQCHSLLCHPYCVNHGGDSLLHVQCFWKTF
人野生型CLRN1异型体E cDNA(SEQ ID NO:46)
atgccaagccaacagaagaaaatcattttttgcatggccggagtgttcagttttgcatgtgccctcggagttgtgacagccttggggacaccgttgtggatcaaagccactgtcctctgcaaaacgggagctctgctcgtcaatgcctcagggcaggagctggacaagtttatgggtgaaatgcagtacgggcttttccacggagagggtgtgaggcagtgtgggttgggagcaaggccctttcggttctcatgctattttcttgaccccttcatgggactcccaacaggggtaccccatttactcagcctgccctgctcaacctcttgcaggagggagcacacgagtgaacgagtgcaggaaccagctggctgctttagtgctgtgaggagtaaactccatgcaggccctgcagcagcaaccagtttttccagatttgctcaaagcaatcccagtgagcatccacgtcaatgtcattctcttctctgccatccttattgtgttaaccatggtggggacagccttcttcatgtacaatgcttttggaaaaccttttga
人野生型CLRN1基因组序列(SEQ ID NO:47)(NCBI登录号NG_009168.1)
1 aggagatact tgaaggcagt ttgaaagact tgttttacag attcttagtc caaagatttc
61 caattaggga gaagaagcag cagaaaagga gaaaagccaa gtatgagtga tgatgaggcc
121 ttcatctact gacatttaac ctggcgagaa ccgtcgatgg tgaagttgcc ttttcagctg
181 ggagctgtcc gttcagcttc cgtaataaat gcagtcaaag aggcagtccc ttcccattgc
241 tcacaaaggt cttgtttttg aacctcgccc tcacagaagc cgtttctcat catgccaagc
301 caacagaaga aaatcatttt ttgcatggcc ggagtgttca gttttgcatg tgccctcgga
361 gttgtgacag ccttggggac accgttgtgg atcaaagcca ctgtcctctg caaaacggga
421 gctctgctcg tcaatgcctc agggcaggag ctggacaagt ttatgggtga aatgcagtac
481 gggcttttcc acggagaggg tgtgaggcag tgtgggttgg gagcaaggcc ctttcggttc
541 tcatgtaagt agcaattgca tttgagttat ttaatgcttt aggcagactc ttcccagtgt
601 tgcgaggaat tatatttgag aattttgccg tgtttactgc aggacttttt aaatcggtgt
661 gaaccatatg aaaaacctat gactctgagc aatttcttct tcctagtttt tattatttta
721 tacttgcttt ttattataat atagagttaa ttcattgtta cataattaag gtttttggaa
781 atattggcaa ttaagatgct taagtattaa tatttatgta aaaaattatg gagtcttttt
841 aaaaaagtaa acttggggaa ataggaaagc tgtaaagaat gatctttatg ctttttgttc
第901章
961 attttgtttc ctgctcccca ctccctccca ttattcctgc taagaccttt cctgctgcta
1021 aatattcagt tttcattttt aactaatttg gaatcatttg gctatagaaatttaaaatga
1081 tctgctgtgc taactgggaa agaaatggat gcctatttag tatagaacattttaaactga
1141 ttgacctgca aatcatgtag agaatatgag agagattttc ttgttgtgatttttgtgaaa
1201 tggaagtgta atccacagta tttataacct gtttatctta agaagagaatttttaaaaat
1261 taccatgtga ataggcaact cattaaatga aaattaatag gaagtcatttgttatatctc
1321 ttacaacaca cattcagaag ttattattat ttcagaaggg ctggtttggaacaaccttat
1381 gaagacacag tcagtaaatt actgcataaa tcactcttca ggaaaggaggttaccaactg
1441 aagcatttaa aatgaattat tattttgccc aggttttttt tttctttctagtataggtag
1501 aaggctaaat taattgaatt tattattaac atatgcagtg cctaattaaatttcagtgct
1561 ggtctattta tatttctgca acattcctta tatcttctta gcagtcattggacaccaacc
1621 ttcagctcac ataggttact aagtgatatg aattttcata gggctccagaaaatttccaa
1681 gaattggttg ttagcttttt aattgatgaa gtggatacca gttcttttcactgaatggct
1741 tttattcatt aaggtaatgg ggctgttaga gttgcttagt tttcctggggaaggggaagg
1801 aagaaaacaa agcagaatgt catgtgatat gcaactgtat taaaaaaccgaaaaggaaaa
1861 aagttgagag agatgattta accgtgagtc accggcagcc aaagcgtgagtaaagcttct
1921 cacagatgaa tttagacaaa agcggagaag gtactggtga attttctggagcctttacat
1981 tttctacagt gaaatggaga taaactttac tcatgccata ggacatgtttcaaaacaata
2041 ataagatgtt ttctgaacac ttactacata ctaagcactt tatatgctttgtctcattta
2101 atccttacac agccacattc ttctggggtt tagcgaatga tttttgtggttgtgtcctat
2161 gcttgtcctg tctaaggatg aagttgttct aattgggtgc ccctccttttgctttctgtg
2221 aggacttgca gaactggtgg ggtttaaaca gtaccctcac ttatctcacagaatttcatt
2281 agctcccaga tacccctgac attctccccc tagcctagtg aagaaaatcttccatttact
2341 tgttcattct gcagtgacag ctccatcaat atacaataga ctatacatattaagtgtact
2401 gtatatacta tacatgttaa aaatctcatt cattttggtg aggcccagctaagaatactt
2461 acagtagagc tttttttttt ttcctaagca taaaagtatc tttttcaatgcagcatgaga
2521 cagagttggg aaaaccaaaa taaatagatc caatggactc cccaaagaggataatattca
2581 tttaaataaa cacccctctc agtgttaaaa ctttctaatc aacatgcctttgggacacat
2641 tgcaccctca aagtttacac tcccattgca acgcagcttt gtggttcacgttttttccat
2701 tcagaatgtc attaccctgt caatgatgtt tcatcaacgt ttgcttggatgagaatcctc
2761 tgatattctt cctgatagaa atgtataagc cctgttcata taaatgaataaaagatctaa
2821 ccttactttc tcagtagtgg cttccttgga gcaaaaagca gggacctccagagagctcag
2881 gtggatgact cttttctgtt tcttccagag ctcaacttac aattagtgcacaattcattt
2941 cccagaatgt cttctttctt attgtgcctt tagaaagtta ttaagcaaacatttgaattc
3001 acagaatctt accagtgtaa gaggaatgga aaaggtaact tatcaaggtaacaatcactt
3061 cgtggccagt tttttcggct cactgcaact acccctcctg ggttcaagcgattctcctgc
3121 ctcagcctcc caagtagctg ggactacagg cgtgcaccac catgcccagctaattttttt
3181 tttgtatttt tagtaaagac agggtttcac catgtgggcc aggctggtctcatggcaagt
3241 tttctttgtg ttgtcatgtt attatcaatt aataggaatt tatatttcagttctgttagg
3301 tggataaaca ctattttgca tacctaaatg tttcatttat atcagcactggccaataaaa
3361 atatactata agcaggccgg gtgcagtggc tcacgcctgt aatcccaacttttgggaggc
3421 caacactttg ggaggacaca gggtcaggag atcgagacca tcctggctaacctggtgaaa
3481 tcccgtctct actaaaaata caaaaaatta gccgggcgtg gcgggggcgcctgtagtccc
3541 agctacttgg gaggctgagg caggagaatg gcacgaaccc gggaggtggagcttgcagtg
3601 agccgagatc tcgccactgc actccagcct tggtgacaga gcaagactctgtctcaaaaa
3661 aaaaaaaaaa aaaaaaaaaa aaaaaatata tatatatata tatatattacaagccacaag
3721 ccacatatgt acttttaaat gtcctagtag ccatattaga aaacaaaagtaaaaaggaat
3781 agatgaaatt aattttaatg atttttttaa acccaagata tccaaaatattatcatttta
3841 acatataatt aaaaatttat tgagatgttt tacattgttt ttttttttcttgacgctgtc
3901 ttggaaatct agagtgtatt ttacatttac attacatcta attcagtctagccacatttc
3961 acatgctcat ttttttgtgt gtggttttat ggagcagaga gtttaataggcaagaaagaa
4021 aagagaaggc agaagaaaat ggctcccctg tacagagacg cgggggtggggcgctccaaa
4081 gccaaaagag gaggtcccta agtatggtag acaccagcca ggaatatatgcagtgtctgg
4141 aggaggggat gtctgatttg catagggtca catgctcatt tttatggctactgtattggt
4201 cagtacagat ttagatgggg atttgctctg aacaagttgg tgattgatggtgttcatatt
4261 ttaattgaat ttttcctggg ttctgctgta cacttgtatg tgtgttagtttcatgtgcaa
4321 tgcttgtgtc acttttaaaa cccagatata tggcataaca tgagaatgaaaaatggacca
4381 gaaaaatagt ttggcaatgt agtcatgttt gttcctatta aatgttccctattgaccact
4441 ctatctcttt taattataac aagaatctgc cctgccagca tgcccagttacgctgggaaa
4501 acttctgcct catttactct ggctgattct catccactta tgggtcagtggttcattttc
4561 tagaggtcac cagcattcat acctagcata caatttcatt cattataatgaaggaatgtt
4621 ttcccttcaa agagacacaa ctagtgggct taatttttct tgatatgtcacctgtaaaat
4681 tttaatgatg atgtttaaac tctaaatgta gccatcaaga caaaaactgcaaattttgag
4741 cctcagtgtg tgtgggtggg tttctgtttc ggtaatttga aacattgcagaatatcatca
4801 aaatatgata cccaagaatc atatggtatc aatcattcct agatatactgatctattcat
4861 tgccaagata gttcaatgag ctggcaaaaa catatggaat tattttcttaaaatgtgaaa
4921 aataaaattt aaccaatcat gtatcacagc ttgcaacttt agtcatactttgaaaagcat
4981 tttaatttgg acctcatgat tgaaaattta taaaaagctg aacagaaattagttcacttc
5041 atattttaga aaagcagagt ttctttacta aatgaggcat ttgacccaaattggagagaa
5101 aatgttgaaa ctacttctgt gagcaagcag gtggcttctc aaacacatgttgggatgaaa
5161 tggttgggcc tcagggtctc agtgcctgtc actgagagtt ggcactctctatctccatgg
5221 tctcctccaa gtgtgactct tgtctcttgc tgacctgacc tgccccaagtgactcactgg
5281 tcatgaccct gcacaccttg cgtctctcct atcaccctgc cgatggcagagctacaaagg
5341 tctttgatgt agctctgtct gatatcctgt gtttccccct atggtctgtgtggaagcagg
5401 tatgggggtg tgtaaagggg aagcctatga agttcatctg caaagactacctggttaggg
5461 gaggagagga agaagctata tgcaccattt caccagcaag catgggctcttctgcctttt
5521 agcttagggg tcctgttgtc tagtctcact cacctattaa aacagtccagcaaatagagg
5581 ttttgtttac ctcccattaa aaaaaaagca attaatggaa tagaagataataatgtatga
5641 gaagcactat tgtgaaagaa aaaccttcaa cttctctcag ccaaataattgcttcctcct
5701 ctgtccttcc cagaccttga tgtttgctct attatttcaa aacaactatattataaatat
5761 ttgagaatgt gtatttccct gcaaggagat cttaatcccc aagaaggcaggagctgtgta
5821 ttattcatcc cagtgctcct tcaaaccagg gcctcagaca gtgcatggcccaaagaggta
5881 cttaataaac gtttggtaaa ctgacactat tgaaattaag caacctggatttgaggtggg
5941 tctctgccac tcacaagaga ttacgctttg agaaaattcc atcacttcattgattttcag
6001 ttcttgcatc tgtatatggg agacgatact aggtgatttc tgacatctctcaccgtttaa
6061 atgctctgtg atctatacaa cgaggggctc gctgttctag acaagttccttccagcttta
6121 cagttgcata acccttctaa tcttagtcac atgatgactc cactgacagatttttggcca
6181 ccatcattag acatgctgag ttacgtgtgc ctttgctctg atcctcaaaactcatgattt
6241 ttaaagtttt ctgaaatatc taccatttat caggatccag atggatttcatgaccaaagt
6301 ggatgtttct tttctctccc attacaatct tttacttttt gtgtgggaaattgcatgtta
6361 aagaaaggga aattgaagaa tgggatgctt tggaattctg gcaagatggattagtgggtt
6421 ccagaaagta ggggcagcca caaataccga aataaatgag atcgtattattgagaaagca
6481 caaatggaag aaggtcaaaa gcaagaagaa gctgacatcc tgcttcctccaatttttgct
6541 ttctctgttt ttccaagaaa ctcctcttcc aagccttgct gaaaaactccactttcctaa
6601 atctaacttc ttaaactgat aatggcaaga agttaggaat gaccaatatgtttaacactc
6661 caagagtatt tgttttgttt tgttttgaga ctgggtctca ctctgtcgtccagcctggag
6721 tgcagtggtg tgatcacagc tcactgcagc cttgacctct cctgcccaaggaatcctccc
6781 acctcagcct cctgagtaga agggaccaca ggcatgtgcc actacacctggctaactttt
6841 aaaaaatttt tttgtagaga tggggttgcc caggcaggtc tcaaactgctgggctcaagc
6901 aatcctcctg cattggcctc ccaaagtgct ggaattatgg gcataagccactacgcctga
6961 cctctccaag ggcattcttt acccagaaga ggaacttggc agaacttatcctccaattgg
7021 tgaggaatat ggagaaaatg actttaagca aaggaacttc tggttctgcctacctaatcc
7081 agaaaaagaa gttttatttc tcccttcccc tagtaactat cttcccatattcacataaaa
7141 aagtacagaa tcaacattgt tcaagaatta taattttact tgtaagcacatgtgcacacg
7201 cacacccata taccttcctt ccctttaaat catcccacac cctaatagtagtaaaatcat
7261 tgacccgagc atacctggga gaggaagagg agtctgacag gggcaggttctaagtggcac
7321 tcctggaact taaccctggt gtatatgaac tttacctatt gaaggatgactcctcaactg
7381 ttctcacaat ttgctgctct gctttctttt ctaatttctg aaggtgactcatcttcccca
7441 aggactttca gacttctcag aagaaaaaaa tattgggtgg gtctctgccactggcaaaag
7501 attagacttt gagaatcata aaagtatatc agtatatact cattaatattgaattactat
7561 aattaatatt atgatattga tataatgata gaatgatatt gataaaagcaatattcaata
7621 atgaatatta tttcagctgc ccacttattg ggtgcctcat aggtgccaggcattttgtat
7681 gtattatcta caacccttac atgggacata ttatgatgct gtttctcttgaagaaatatg
7741 gaaactggaa acagagaggt caccacaatt ttccaaagtc acatagctaataggtagcag
7801 acttgggatt caaattcata tgcatatggt aaatcatgct cttcctctgctacattttgc
7861 ccccttagaa tatgaaaaag ggatacaaag agatgaagaa aatatgtaagattatccttc
7921 aatttcacta tcttttttaa agtttttttt attatacttt aaattctgaaatacatgtgc
7981 agaacatgca ggtttgttac ataggtatac acgtgccatg atggtttgttgcacccatca
8041 acctgtcatc tacattaggt atttttccta atgctatccc tcccctagtcccccacccac
8101 cgacaagccc cggtgtgtga tattcccctc cctgtgtcca tgtgttctcattgttcaact
8161 cccacttatg agtgagaaca tgcggtgttt ggttttctgt tcctgcgtcagtttgctgag
8221 aatgatggtt tccagcttca ttcatgttcc tgcaaaaggc atgaactcattttatggctg
8281 cataccattc tatggtatac atgtgccaca ttttcttaat ctagtctatcattgatgggc
8341 atttggctta gttccaagtc cttgctattg tgaacagtgc tgcaataaacatatgtgggc
8401 atatgtcttt atagtagaat gatttataat cctttgggta tagacccagtaatgggattg
8461 ctgggtcaaa tggcatttct ggttctaggt ccttcaggaa ttgccacactgtcttccaca
8521 atagctgaac tagtttacac tcccaccaac agtgtaaaag cgttcctatttctccacatc
8581 ctctccaaca tctgttgctt cctgactttt taatgattgc cattctaattggagtgagat
8641 ggtatctcag tgtggttttg attagcattt ctttaatgac aagtgatgatgagctttttt
8701 tcatgtttgt tggccgtata aatgtcttct tttgagaagt gtccgttcatatcctttgcc
8761 cactttttaa cggggttttt tcttgtaaat ttgtttaact tccttgtagattctggatat
8821 tagtcctttg tcagatgggt agattgcaaa aattttcttc cattctgcaggttgcccgtt
8881 cactctgata atagtttctt ttgctgcgca gaagtttttt tagtttaattagatcccatt
8941 tgtcaatttt ggcttttgtt gccattgctt ttggtgttta gtcatgaagtctttgcccac
9001 gcctatgtcc tgaatggtaa tgcctaggtt ttcttctagg atttttatggttttaggtct
9061 tatgtttaaa tctttaatcc atcttgagtt aatttttgta taaggtataaggaaggggtc
9121 cagtttagtt ttctgcatat ggctagccag ttttcccaac accatttattaaatagggaa
9181 tcctttcccc gttgcttgtt tttgtcaggt ttgtcaaaga gcagatggttgtagatgtgt
9241 ggcattattt ctgaggcctc tgttctgttt cattggtctc tgtatctgttttgatacaag
9301 taccatgctg ttttggttac tgtagacttg tagtataatt tgaagtcaggtagcgtaata
9361 cctccagttt tgttcttttt gcttaggatt gtcttgacta ttcaggctcttttttggttc
9421 catatgaaat ttaaagtagt tttttctaat tctgtgaaga aagtcaatggtagcttgatg
9481 ggaaaagcat tgaatctata agttactttg ggcagtatgg ccattttcatgatattaatt
9541 cttcctatcc gtgagcatgg aatgtttttc catttgtttg tgtcctttcttatttccttg
9601 agcagtagtt tgtagttctc cttgaagagg tccatcacat cccttgtaagttgtattcct
9661 aggtattttg ttctctttgt agcaattgtg aatggaagtt cactcataagtttgctctct
9721 gtttgtctgt tattggtgta taggaatgct tgtgattttt gcacattgattttgtatcct
9781 gagactttgc cgaagttgct tatcagctta aggagatttt gggctgagacgacagggttt
9841 tctaaatata caatcatctc atctgcaaac agagacaatt tgacttcctctcttcctatt
9901 tgaatacgct ttatttcttt ctcttgcctg tttgccctgg ccagaacttccaatactgtg
9961 ttgaatagga gtgttcacca cctattttaa gaatagtatt gaagcctcacaaaagctggt
10021 tctcatgtaa ccatctgaga atatttggcc ttatgacttg aattcattcattgccttttt
10081 atttcacatt ttagtgatcc tgatgtctaa atcttaatct ttgatccttgcaaggtaaaa
10141 tagccaagtc aagcctgttt aataatattg gttgaggaag tcacatgcttatgatcaatc
10201 tttgggttat gtaattatat taccttaatg ttggcagttt aggtgtaaggcagagatatc
10261 tgatcacatg tgtggttagc taatttaaga tcactgccaa ctaaaatcttcatggtatga
10321 tcttcaaagt tagctacttt gaccacagca atgatttcac cacagcaattaacaaaatgg
10381 cagactcttt cctgaggtgg catgaacagt tttaaaacaa agtcaaggaccaaaagaaaa
10441 gcaggcacat ggcatttgat tcatttcaaa aactagtatt gtattaagagccaaggggat
10501 agaattgtag catcaattaa aatcttgttt gaaaaaaaat aaaaacaaacgtccattttt
10561 atctctcaaa tatattaggg ttttcataaa gttataggtg tatttttaaaaaaacaaaac
10621 tcatatacat tagactgaaa aatttgcctg tcatctcatc atgcagctaaatgcaattgt
10681 ctatggcgag atacactctt attagaggta tgatagcact aactaatagcaaactttgta
10741 cctggtagtc taatttatgc agggttcata tttcgctccc tctcagcatgctgtaactgt
10801 ggcaaagcca ttctcaggag ttattacccc aacataatca tacccctgtggattaggagc
10861 agttaaatgg gtcctgttat cagagacaca tatgtgccac agccgctgtcatccctaagc
10921 caccgtgggt gattaagact cactgatggg actacctctg aataggcttgagtgaggtgg
10981 atacacttca gctgagagaa attcaggtaa ggggctgaga aaatcagattttgaatggtt
11041 ttatcatacc atcaggtctc cttttaagtg ctggggtcat ggatttcattcaacctgacc
11101 acatagcctt tggaagcttg gctcaatacc tgagtgtgag attatgggtgatattaaagg
11161 agatgaatgc attgagctga tgtcagagaa tgtcttttac tggattttcataatgactgg
11221 ctgcagatgg gctgagggga aagtcagatc aagagcattt ctgtaagaagaaagaaatct
11281 tccctcttat tctctttcaa gaaaatgaat agctgagcac caagaggccaaatacttttt
11341 taaaaaacac atccttttat gtagagaagg acaggttgag acgaaaaacaggacctctga
11401 aactgtcttt atagctttaa tctaggaaga aattgcggca ccattgctgacatcattatc
11461 agaggctgcc ttagttctga gagcttcaca gatggccttt tctgcattttacatctggcc
11521 agatgaaggc aaaaaggttg atgaaaccaa aactattaga tcagtggtccataactctgg
11581 ctgcacttta gaatcatctg gggagtcctt aaaactactg atcctgaggctccatcccag
11641 accaattgaa tcaggatctc tgggggtggg acctgagcat tggaatgctttaaaagttcc
11701 tcagggactc taatgtgcag ccaaggctga gaatgactga ggtggatggtggccaagaca
11761 ggtgaggcca agagttagaa gcccttactg ttagggaagg cagaagccacaaggaggagg
11821 ggagggggaa ggagcagtat ttagcatttc ttccacacag ttggggggttttctgatcaa
11881 aattaggctg ggatctttcg cttccatttt catgaaggtc ttatgctttgtccacagcca
11941 cctggcctca gggcaatgag caatctgatt gatgaatttt cagtaagaaactgagcacac
12001 ttggctctca gccccagtgg cttcccctgt ttccaaatct gcccaccagttacaggagcc
12061 tgctcaccaa ctggttgggt taaagaagtc ggctctgtcc ttggcagggaggccttcagc
12121 tgtctggccc tgtctgtgac tgcgtgggtg aagctgccta atttggggaacttgatggaa
12181 gatctaagct atgttctcta acagttttat cagaaataaa gttaacttttgacctccatc
12241 tgcctgtctc ctgtggaagg gctctgctcc ttccaaagag actctcaggggttctcctta
12301 gaggtgtgtt atcagtccaa agatcatttt agaccagcca ttacagaggatgtccaagaa
12361 attgcacaag ggaaatagaa gtaagaatga gagcaatata tcagatagtaaggaaagtat
12421 gtgactggtt tcaaataagt aattaaccat aaatccaaag ttcctgcattagttatagca
12481 atagtcatcc acctggtcag gaaaaaaaaa gtaaaagact gagctgcaagatagaaagtt
12541 tgcctgaatt ccacgtactt caaggactac tatggaggat tccttggtcccaatgcagag
12601 acatgtactc tgaccaccca tgggccaaat ccctcttacc caccctcagtgattcctcct
12661 gggacctcac tacattgagt tcttacattc cccactcttt tcgggggaaatataaccctt
12721 ctgctcttct catgatgtta aaaatattta gacaattact taaaatttacaacaatcttc
12781 cacataaatg atctcactta tgtttcttgt gagctctgtg atttatttctattatcatct
12841 atgctgatag ttaaggaaac tgagatatcg agaccaacat gcatagtaaatggcaaaacc
12901 agatgaattt taaactttcc taactccaaa agccacatcc tgcccaacccgccatgctgc
12961 cgctcagtta atgcctggct gtttgtctcc ccattggccc ctctacccattgtgctttga
13021 tggcacactg tattccaact gcctgagact cctggttaat gccattacgtacagacttag
13081 gttgaattta ctaggatttt taagatttgt aggataagag atatgactgttagactggaa
13141 tcagcaatag ataaaaggtt aacaaagttt cagaataaaa tataatagaaaaccccagca
13201 gatagaagta aaatgaatgg taagacaact gaaatgaaag ccatacatttagaaatatca
13261 aataaaacac agattaatgg cagacaataa aggaacatac ttagcagttagtaaaaacac
13321 tttttacctt attcttatta ccctccagta accttttttt tttttttttttgagacaaag
13381 tctcgctgtg tcgtccaggc tggagggtag tgatgtgatc tcggctcactgcaacttctg
13441 cctcttgggc tgaagagatt ctcctgcccc agcctcctga gtagctgggactataggggc
13501 ccatcactgc acctggctaa tttttgtatt tttagtagag acggggtttcaccatgttgg
13561 ccaggctggt cttgaactcc tggcctcagg tgatccaccc gcctcagcctcccaaagtgc
13621 tgagattaca agcgtgagcc accaagcccg gctgtaacct attgaaaataacattacttg
13681 acatgtgaga caaattattt gtaagttaaa gagtttatgt gccttcaatgctcccaccct
13741 tccctcccct aaaaagatta ttgagtgccc atgatgtgcc taagccttctggtagactct
13801 gagaatgtga agagagttag aggatacttg ttcaacaacc cagaatctagcagaagtgtt
13861 ttgaaatgac cagccacttg ggagagctat gctagcatat cattcaggatgggctgggtc
13921 atgttttaat aacaagtaag tttgaacttt ataggtttga aacaaaaaagatgtgtttct
13981 tgctcacagt tcatattttt tggagattgg ctggagcttc attccaggatactgccacca
14041 tctggaatgt tgacagttac cgtaacagag aaagagttgt ggaggctgtcacactggcaa
14101 ttaaattcgc tgacctggaa ctgacacatg ccacctccac ttatattttattggccaagg
14161 cttgttacac agccacatct aacttcagag aggtcaagat gagcaaatcctaccacgagc
14221 tatagatgga tgagtagcac tcattattat cacaattatt ttatttgttataaaaactcc
14281 aagaaggaga ggtactctat gtgaggaata ggcataggaa aatcagagggaagttcttaa
14341 agatgagcta gatttcacta gatggcattg aagaaacatt ccaagtaaatgaacagcata
14401 agcaaatgca tgaagaactt attgtggtcc tagtacagac gatgcgtgagagtgtggagg
14461 agggaaaagg taagactgga gaggaaggca ggaaccagaa caggacagactgtgttcact
14521 gtcaggcagt taagtctatc ttgtaggcaa catgaagcct tttaaggaaggcaagcagct
14581 atgtgacagg acagaagatg gattggaaga aaatcaaaag agaagtggggaccagtcata
14641 aggctcctcc aatatttggg gatccaaacc aaagcactgg cagagaaatagaaaggaagg
14701 gaaatatttc caaaatattc aaaacagaaa ccaagagaac ttgatgacagaagatgaacc
14761 caggtttcta ctgaatggac agttgttaca ttctctgaga taaggaatacagaaggaaaa
14821 agttgagagg gaatatgaaa ttatttttaa tcatgtttaa tttgatcacttgtggaacat
14881 caaccagaga tgtccatcag ttacaccaat ttgtaggttt tgagagaggcctgaggtaga
14941 ggcagagaag tgggaatcag cagattagcg gcagtagttg gaaccataactgaagatgag
15001 atttcccagg gaggggagtt gaacaggaag gtagacaaag gctgagtgcagtggctcata
15061 cctgtaatcc cagcactttg ggaggctgca gtgggtagat cacaaacaagatcaggagtt
15121 caagaccagc ctggccaaca tggtgaaacc ccgtctctac taaaaaaacacaaaaattag
15181 ccgggcgtgg tggcacacac ttgtaatccc agcctcagga ggctgaggcaggagaattgc
15241 ttgaacccgg gaggcagagg ttgcagtgag ccaagatcgt gccattgcactccagcctgg
15301 gcgacagagc gagactccgt ccccaccgac cccctaaaaa agaaagtagacaaagatgtg
15361 tcctagaaaa cactaatatg aatgggtaga gaggggagac ttgtcaaggagatcgagggg
15421 agagtcagtg aggtgaaacc ttagaggata gaccttcacc aaggaagtaacagtcaacag
15481 gcctaaatgc cacagagatg tcaaatgaga gacactggaa atggttctttgaatattaca
15541 gccagaacat cacaggagac catttccaaa gcagtcttga tgaagtggtggggaagggag
15601 gtccctgaag gagctaagga gggactggga gatcatgacc cagagataagtgttgcaggt
15661 ataaaaggga aagactgaga tcaggaaata gccacaggat ccctaaggccaggcttcggg
15721 tggggtggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tataaaatgggaagaccttg
15781 agtataattc tgtactaaga agatagagca gtagagagga aaaggctgaagacagatggg
15841 agggtaaata gtgaattaga aaggtctgtg caaagatgag aaaggatgagtctgaaagca
15901 cagggagaag ggccagcctt ggacaggaga aaacatttct ttcactaagaataaagggaa
15961 ggttgggtat acaccacaaa gaaggtgtag atgggtggca atggagttctgtcaagttga
16021 gggcattcca tgatagcctc acctttctct gtgaaatgag agagtttagtttacaagata
16081 tttctgagca cttcataagc caggttcata gactgaaaga agtggaggtggagtgtgata
16141 ggtccttaag aataggggaa gtttggaata tctgacaagg gacagagaggaaaaaactag
16201 aaaaggcttt gcagaatgtg ggcccacaga tcagaggcta aggggtccccatttgtgcag
16261 gagagtaagg gcagggaggc aaggctcaca gcccaaaata tagagcccctcaccaaatga
16321 ctgcaggagg gcagctttcc tatgagagca tccctatcac tgttttcactccgagtcatt
16381 aacttacgac ttactcagct ctgtttcgta atagcagact cgagtaatgagggtatgaca
16441 gcctctctct gcatgccaag gtatgcagcg tggatttcct ttttcgctttctctctcctg
16501 tggcttaggt gccttctgtt ctgctaccag gatagagaac ccagtgactagtttcttcta
16561 gctctctttt tctgactagg tatcttgtca gaaatttctg cttaccagacttcatggaga
16621 gggaatcaag ctttgaatca gggttgaaaa agtagagctt aatatatatattacaaaatg
16681 ccactcacgt tcttgaggtt accttgtatc tataccacaa ctagcattcttttagaaagc
16741 accattaccg aagtaatccc tttcctggga attcacccaa aaaggttattcccacttatc
16801 ccccatctcc aaaataaaaa agaaaaatgt gtgtgcttag agatgttcctggaagcatga
16861 gctgtaatac tgaaccaata gaagacgaac taacagattg cagggcatccgtttggcaaa
16921 aaacttatgc agttatctaa atgatagtta tgaagacaat atgtataacacattatattc
16981 tgagtgaaaa gaacagaagg tgatttcaaa actgcattgg gataatagtaatataggaaa
17041 tagtgagatg aacaaagatt tcaaaggaac aaaaataaag aaaaattttgctttttatat
17101 tggtaggcgt atgggtgaaa ttccaatttt aattttaatt tcatagttataaaattgttc
17161 ataaaaaaag gtcccccata gacagttggg ctttgggaca aactaacagaaacagagtag
17221 gaagaaaatt catcttcctt caatcccctt tctctgctta aaacaaaacaaaaaagagct
17281 ttgtcatgtt caggtgtgca acgaattctt tttccaaatc tggaactttacatctgctat
17341 taaacaggag tcagtttcca tgtaacatgt tgacaatccc ccaagtgtgttggaataatt
17401 ttttttaatg aggagatttg aaattccatt tcaattgcca acctgcctctttcaacttct
17461 aaaaacaaag taaaacaaaa caaaaacaca ctgggtccta tcaccccctcttgctactac
17521 tattttatct ccattgccct gaattctttc caaacttctt tccacccagctttgatttgt
17581 tttcagtcgg gtttattgag gcataattta cgtacagtaa aattcatccttcttagattt
17641 agaggtctat gcattttgac taatgcatat tggcttataa tgactaccacaacaaagata
17701 tagaacacac ccatcactcc cgggttctcc ctgtcccttt tttggtccatctcctctcct
17761 acccccaacc ccttggcaac cactgatctg ttttctgtcc ttatcattttgctttttcca
17821 ggatgttgta tataaggaat catgcagcat gcagcctctc gagtctgacttcttccagtt
17881 agcacagtta tttaagatct atccgagtta ttgtgagtag cagcatcttttttattgctg
17941 actagtattt catcacatgg atgggccaca acttgtttat ctgttcacctgtcaatggat
18001 actaagttgt ttccagtttt tggcaaatat gaataaagta aacatttgcatacagatttt
18061 tgtgtggaca catgttttca attctcttag gtaaatactg agcaatgggattgctgggtt
18121 atatgttaag tctatgttca gttttctaag ttctgaaaca attggatatctatatgcaaa
18181 aatacaaaat taaccttgac tcaaacttgt accatacaca aaaaataacctgaaagagat
18241 cacaggtgta aatgtaaacc tagaactaaa aacttcaagg agagaaacatagcagaaaat
18301 atttgtgacc ttgcattagg caaagacttc ttagatttga catttgaaacatgatacata
18361 aaaaatcttg ataaattgga gttcataaaa ataagaacta ctcttcaaaagacactgata
18421 agagaatgaa aatacaagcc acagacagag aaaatatttg tgaatttcttatctgataaa
18481 gggtttgtat ccagcatgca taaagacttt tcaaaactca ataataaacaatccaataag
18541 aaatgcacaa aagatacaaa cacatcatcg aaaatgacct atgaaaggcaaataagccca
18601 caaaaaaatt ctcaacatca ttagacactt gggaaatgca aattaaaacaacactgagat
18661 aaactacata tctattaaat ggctaccact ttaaaaacct gtcaagtgccagccagaatg
18721 tggaacaagt aggactctct tacattgcta gtgggaaggt gaatggtacagccactttgg
18781 aaaacactcc gcagcttctt atagttacac ataggacctg ggggtagaggatggattgac
18841 tgtaaagggg caaaacttcc tggtaggggt ggggaaagtt tttagaagggtgaaattgtt
18901 ctatatcttg attattgtgg tggttacaca actgtctgca tttgtcaaaactcacagaac
18961 tgtacactaa aaaggtatat ttttatgctc tgctaatttt actttaatcttaaaaatagg
19021 aaggaaaaaa taaaatcaat gccactgtgc gactttgggc aagttacttcacttctctgt
19081 gccttggtct tttgaaatct atacattaag gataaaataa taccttcctcatactgttag
19141 aattaaatgt gctaatttat gttttatata tataaagtac ttggccgggtgtggtgactc
19201 acacctgtaa tcccagcact gtgggaggcc gaggtgggca gatcacttgaggacaggagt
19261 tcaagactag cctggtcaac atggtgaaac cctgtctcta ctaaaaatacaaaaattagc
19321 tgggcttggt ggtgcgtgct tgtaatccca gctacttgag tggctgaggtgggaggatca
19381 cttgaactcc agaggtggag gctgcagtgg gctccaccca ctgcctgggtgacagagcta
19441 gactccatct cgaagaaaaa ataagtactt gaaacatagc aaatgttttataattattgg
19501 cttttttttc ttattgttat tacttgcatt attgctgttt gaagaagtttggtgataatg
19561 gagagaaaag ggcaattagg ggtctgggat ggtttaagta tgaggagaccgagacacatt
19621 gactcagagt gaagaaatca aagataagag aatgaaagaa agggagggtaattctgaacg
19681 cacagacaaa gttatgttac taacgtggca tcggctgtgt gttgtaataaataactccct
19741 ttcacttgtc aatagctaat caaatacttt ctggagacca gaagtgacttgctggatcaa
19801 tgacaactcc tccacagatc aaaatgttca aatccttttt ctgtgttgtaatcctaaatc
19861 taaaagaaca gagagaccaa gcaaatctac ctcccaacat cattaaagtgacaactctca
19921 gtatttattt gaatggtctg ctctcagctt caaccaagga aaagtcaaattagtgttggt
19981 cagaaaacag aagggtgtta cgagagttct ggctggtcat tacagacttggggatttttg
20041 attaaaagaa gaagaagaag aagaaacctg ataaagtgta aatatagcaagcagggatta
20101 gtgtcctgct gggtcatgtt ctcacaacag tgagaatttc agagatttcataagaattaa
20161 actgctccac atgacaattt attttacctt ctggcttttc caggaggcaaatcagtgcaa
20221 cttctttctg cctttgtttc aatttggtaa caaccctcaa ttttaggacaggctaaacct
20281 agccacccta tcagagatga tgaagtagcc atctttttaa caggtggggagatgaatgga
20341 atcagggttt gtttgtttgt ttgtttaata actgctagta aaaaccaagtcaatagctga
20401 ctgagtgtaa gggaggctcc agaaggcagg ttattgtagt atagatgtgactcgacttat
20461 gatgatgtta cttcccgata aacccgtcat aagttgaaat atcgttaaattgaaaatgct
20521 tttaatacac cgaatctacc gaacatcata gcttagctca gcctacgttaaatgtgctca
20581 ggacgcacat tgcctacagc tgagccaaat cacctggcaa cacaggacactgtagagtat
20641 cggttgctgg cccttgtgat gctgtgactg actgggagct gcgcttagtgcctctaccca
20701 gcattgagag tttcttatcg cttattacta gcctgggaaa agaccaaaattcaaaactca
20761 aagtgcggtt tctaccgaat gcttataact ttcagaccat catgatgttgaaaaatcgaa
20821 ccatcgtagg ttgggatcca tcctataaga cgagctacac tgccggaagtgtaagactgc
20881 tatgctgccg gaagatgggg catagtggac aactgcaagt cctgacaacaggaggtcagc
20941 atctgcgacc tttaacatcc acattgacac taccacagtc ttccaaacagagctgatgat
21001 atagtttgga tgtcgtccct gcccaaatct catgtcgaat cgtaatccccagtgttggag
21061 gtggggcctg gtgggaggtg attgggtcat gggggcagag ttcttatgaatggtttagca
21121 cggtcccccc ttggtactgt atagtgagtg agttctcatg cgatctggttgtttaaaagt
21181 gtgtggcacc tcccctctct ctctttctcc tactctggcc atgtgaagtgttggctcccg
21241 ctttgccttc caccatgatt gttaaattcc cagaggtctc cctagaagctaatgctgcca
21301 cgtacagcct ggagaactgt gagccaatta aacctcatct ctttttaaattacccagtct
21361 caggccgggc gcggtgactg acacctgtaa tctcagcact ttgggaggctcaggcaggaa
21421 gatgatttga ggtcaggagt tcgagaccag cctggccaac atggtgaaaccccatctcta
21481 ctgaaaatat aaaaattagc caggcatggt ggcgggtgcc tgtaatcccagctacttggg
21541 aggctgaggc aggagaatcg cttgaacctg ggagtcagag gttgcagagagccaaaatgg
21601 agccactgta ctccagcctg ggcaatggag tgagaccctg tctcaaaaaatatatatata
21661 ttacccagac tcaggtattt ctttacctga gactatgaga gaatggactaatatagctga
21721 agaattttat tttattttta aaaaactttt acgtttgggg gtacctgtaaaagtctgtta
21781 cataggtaaa ctcctgtcat gaggatttgt tgtacagatt ctttcctgctcctccccctc
21841 ctcccaccct ccatcctcaa gaagatccca gtgtctgttg tttccttctttgtgttcgta
21901 agttctcatc atgtagctcc cacgtataag tgagaacatg cagtatttggttttctgtcc
21961 ctgtgttagt ttgctaagga tgatagcctc caactccatc tatcttcctgcaaaagacat
22021 gatctcattc atttttattg ctgcatagta ttccatggtg tatatgtaccacattttctt
22081 tatccagtct gtcattgatg ggcatttagg ttgattctgt gtcttcagaattgtgaatag
22141 tgctgcaacg aacattcgtg tgcttgtgtc tttatagtag aatgatttctattcttctgg
22201 tagtaatggg attgctgggt caaatggtcg ttctgctttt agctctttgcagaatcacca
22261 tactgctttc cacagtggtt gaactaattt acactcccac taacagtgtataagtgttcc
22321 cttttctctg caaccttgcc agcctctgtt atcttttgac tttttaataaaaaccattct
22381 aattagtgtg atggtatttc attgttgttt tgatttgcat ttctctaatgatcagtgatg
22441 ttgagctttt tttcatgttc gttggctgca ggtacatctt cttttgaaaagtgtctgctc
22501 atgtcctttg cccacttttt aatggggttg tttttctctt gtaaatttaagttcctcata
22561 gatgctgggt attagacctt tgtcagatgt atagcttgca aatattttctcccattctgt
22621 aggttgtctg cttactcttt tgattgtttc ttttaccatg cagaagctcctaagtttaat
22681 tagatcccat ttgtcaattt ttgcttttgt tgcaattgct tttggtgtctttgtcatgaa
22741 atctttgcca ggtcctatgt ccagaatgat attgcctagg ttgtcttctagggtttttat
22801 agttttgggt tttacattta aatctttaat ccatcttgag ttgatttttgtgtttggtgt
22861 aaggaagggg tccagtttca atattctgca tatggctagc cagttatcccagcattattt
22921 attgagtaag gagtatctcc tccgttgctt gtttttccca ggtttgttgaagatcagatg
22981 gttgtaggtg tgtggcctta ttttggggct ctctatcctg ttcatttggtctatgtgcct
23041 gtttttgtac cagtaccatt ctgttttggt tactgtagcc ctatagcatatttcaaagtt
23101 gggtaacatg atgcctccag ctttattctt tttgcttaga attaccttggccatttgggc
23161 tctttttggt accatatgaa gtttaaaata gttttttttc tagttatgtgaagaatgtcg
23221 ttggtaattt gataggaata acatgtaatg atattgattc ttcctatccatgagcatggg
23281 atgtttttcc atttgtttgt gtcttctctg atttcttcaa gcagtgttttgtaactcata
23341 ttgtagagat tattcacctc cttgcttagc tgtattccta ggtattgtattctttctgta
23401 gtaattgtga atgggattgc ttttctgatt tggccctcag cttggtattgttggtgtata
23461 ggaatgctag tgattttttg tatcctgaga ctttgctgaa gttatttatcagctgaagga
23521 gcttttgggc tgagactagg gggtttttta gatatagaat catgttctctgcaaacagat
23581 ttagtttgac ttcctctctt cctacttgga tgccctttat ttctttctcttgcctgattt
23641 ccctggccag gacttccagt accatgttga ataggcgtgg tgagagagggcattcttgtc
23701 ttgtgccagt tttcagggag aatgcttcca ccttttgccc attcagtacgatgtttgtgg
23761 tggtttgtca tatatggcta ttattatttt gaggtgtgtt cctttaatacctagtttatt
23821 gacagttttt aacatgaagc agtgtttaat tttattaaaa gtcttttctgcctctgttga
23881 gatagtcatg tggcttttgt ctttagttct gtttatgtga tgaatcacatttgttgattt
23941 ccttatgttg gaccaacctt gcatcccagg gatgaagcct acttgattgtggtggtttag
24001 ctttttgata tactactgga ttcagtttgc aagtattttg ttgaggatttttgcattgat
24061 gttcatcacg gatatcggcc tgaagtttct ttttttgttg tgtctctgtcaggttttggt
24121 atcagaatga tgctggcctc ctagaatgag ttggggagga gttcctcctcctcaattttt
24181 ttggaatagg ttctgtagga atggtaccag ctcttcttta tacatctggtagagtttggc
24241 tgtgaagcca tcaggtcctg ggatttttta gttggtaggg tatttattactgattcccta
24301 aatagaccga taatgatttt agaagtggag tcggtttttt cctggtccagtcttgggaag
24361 gtgtatgtat ccaggaattt atttagctct tctaggtttt ctagtttgtgtgcatatggg
24421 tgttcatagt agtttctgat ggttgttttt atttccgtgg gatcagtggtaacattctct
24481 tcatcatttc tttttttttt tttttttttt ttttttgaga cggagtctcgctctgtcgcc
24541 caggctggag tgcagtggcg cgatctcggc tcactgcaag ctccgcctcccgggttcacg
24601 ccattctcct gcctcagcct cccgagtagc tgggactaca ggcgcccgctaccacgtccg
24661 gctaattttt tgtattttta gtagagacgg ggtttcaccg tgttagccaggatggtctcg
24721 atctcctgac ctcgtgatcc gcccgcctcg gcctcccaaa gtgctgggattacaggcgtg
24781 agccaccgcg cccggcccat ttctaattgt gtttatttga atcctctctcttctcttctt
24841 tattaggcta gctagtggcc tatctatctt attaattttt tcaaaaaaccagctcctgga
24901 tttcttgatc ttttgaatgg tttttcatgt atcaatcctt cagttcagctctgattttgg
24961 ttatttcttg tcttgtgcta gctttggggt tgacttgttc ttgcttctctaattctttca
25021 gttctgatgt tagtttgtta gtttgagatc taactttttg atgtggacatttagtgctat
25081 aaatttaact cttaacactg ccttagctgt gtcccagaga gtctggtatgttgtatcttt
25141 gttctcatta gtttgaaaaa acttcttgat ttctgtctta atttaattatttatccaaag
25201 tcattcagga acatgttgtt taatttccat gtaattgcat ggttttgagcgattttctta
25261 gtcttgactt ctatttttat tgtaccgtgg tctgagggtg tttgatatgactttggttct
25321 tttgcatttg ctgaggattg ttttatgtcc aattatgtgg ttgattttagagtatgtgcc
25381 atgtggtgat gagaagaatg tatattctgt tggttttggg tacagagttctgtagaggtc
25441 tattagatcc atttggtcca atgttgagtt cagatcctga atatctttgctaatttcctg
25501 cctccatgat ctaatactgt cagtaaagca ctgaagtctc ctactactattgtgtgggag
25561 tctatgtctc tttataggtc tctaagaact tgctttatga atctgggtgcttctgtgttg
25621 gatgcatata tatttaggat agttagatct tcttgttgaa ttgaaccctttaccattatg
25681 taacgccctt ctttgtcttt ttttttcttt gttggtttga agtcttctttgtctgaaatt
25741 aggattgcaa cccctgcttt tttctgtttt ctgtttgctt ggtagattttcctccatccc
25801 tttattttgg acctatgggt gtccttacat attttatctt tatctatccatccagccatc
25861 cagccatcca ttcatccgta tcatttttaa ccaataagga cttttaaaagcgcaaccaca
25921 acaccattaa cataaccaat aaaatctata acaatgataa aatatcatctaatactcagt
25981 ccatgtccaa ttttccctcg ctatctcaaa atcgtcttct tagaaatggtctgttcaaat
26041 gagatcacat ggacagagga aggcgaacct cacactgtgg ggactgttgtggggtggggg
26101 gaggggggag ggatagcatt gggagatata cctaatgcta gatgacaagttagtgggtgc
26161 agcgcaccag catggcacat gtatatgtat gtaactaacc tgcacaatgtgcacatgtac
26221 cctaaaactt aaagtataat aataaaaaat aaaaataaaa aaataaaaagtgaaaaaaga
26281 aaaaaaaaaa aaaaagaaat ggtctgttca aatcacaaac cagattcagaaacaatagcc
26341 atacattaca ttttattaat atgtctctta aatttctttt aatctattacagtctttgga
26401 atttttatgt cttcgtttat ccttccaatt attaaaaaaa aagtatttttgtattcattg
26461 aatagacaat gcttgcagaa aagtaaaaaa aaaaaaattt agtacaaaaaggtacatagt
26521 gagctgttcc ttagtctccc ttcccagaag caatgttacc acttttgtacaaatagtctc
26581 tgcctagaca cacatgccag tccctaaggt ggctgtaaca aggtggttaagagtgagaac
26641 atgaattcaa attcctatta tgccactcac taagtataaa tcttggtcatggtacatgcc
26701 tctgtgcctc agtttttaat aatggtacct acctcatagg gctgttgagagaattaaatc
26761 agataagtgc ttaaataact attaatattt attattattc acattcccttttggcttttt
26821 tcccaaatag cagagtggtg cacatatgtc ttcatttatt tggcttgttttttcacctca
26881 catcacattt tgatgaataa ttccatacat gttgttatag atttgcttcattctttgtaa
26941 tcattgacta atattccatt gtatgaatat gctactgcta aacatgtacgttatttccaa
27001 cctcttatta tcaagaaatg ctgcaatgaa tatccttgta atactttagtggattcatgt
27061 gcaaaaatat tcataggata aaatcctgaa agttaaattg ctgagctaaagggtatgtgc
27121 attttaatgc tttatagatt gcccagctgc ctcaaaggag gttataacaatttacactcc
27181 caagaaaaat gcacaagggt ccccatttcc ccatacccta gctaacacaggatattgcta
27241 aatgctttca tctttgtaaa catgatgtat tgaaaatggt atctcaaagttttaatgtgc
27301 atttttctga ttgtgagaag ataaaggaaa tgtagtacaa ctaaacatcagcagtcaaat
27361 gacctggcca tgactcctga gtgaggacac tggtaaacac catcaggatccaaacacctc
27421 tgtatttacg aagaggatgc tccctattgg atagcactaa gcttatttcatgtatgtaca
27481 tatgtagtta gttaattaca tccagcggtg gcaaagggct tgttctgacccaatgaaact
27541 ttctctcctg gcccccttcc agcatgtggt caggagtaga gtgttgtggccatgaggcat
27601 gcatttgtac agatgactac ttactcctcc ttgaaacatt tttttccatttgcttccctg
27661 ctgtctcact catgggtctg ctcctaattc acaaatcact cttttcccagtcttcttggt
27721 tgggttttct cctcttctgt gcttgtagac atgggggagc cccagggcttctctcttgaa
27781 ctacagcttc tccctgggtt catctccttg ggatgtctgt tccaatgggtttaaatacta
27841 gggctaggac tagggagagg tcattgaggc acttagcaca taaagtttaaggaaacattc
27901 tttatcaggc ccatgcaagt gcaggactgg ccctggaggg tgactaccaccttacctttt
27961 ccaccctagg caccttgttt gccttaccct agccccagtc ctctttaacaccccagtctt
28021 ctccctggac ctccagaaac ataaatccta tttgacattt ctacttggaggttttaaggt
28081 aactcaaacg taaaatatct aagacagaac tcttgcatca cttcccatcctggggcccaa
28141 gcctgtctct tctactagtc tatctcagtt aacagcatca ccatttattcagttgctcag
28201 gacaaaaaat ttgaagtaat ccttgactct tctttttttt tttttgagacggattctcac
28261 tctgttgccc aggctggagt gcagtggtgg gaccttggct cactgcaacctctgcctcct
28321 gggttcaagc aattctcctg cctcagtctt ctgacctcgt gatccactcgcctcggcctc
28381 ccaaagtgct gggattacag gcgtgagcca ccgcacccgg cctggattcttttttttttt
28441 tttaaacaag tcctatcttc catctccaaa atgtatccca aatctgacaacctctcccac
28501 cgtaggccag cccccatctc tcccctctga aaatagcctc ccttagatctctggacattt
28561 gttcttcccc acccccttgt gatcactatt cagcattcag aatgatcttttaatattatg
28621 aaggagactg tgttcctctc ctacttaaaa ttctctagtg gcttcctaataaatttagaa
28681 taaaaagcca actcctcgcc atggtcacca ggccaggatc cagtgggtacaacaatctgt
28741 tcccagcaca ataatcccac ttctgcctcc ccaccattca ccaggctccactgcactggc
28801 tcattcctgc ctcagttgtg cttcttttcc ctggaaagtt ctttctgtagatctttaaag
28861 ggtgatttcc ttctcaacat tcaggtgtca gctcgtttca ctttcctgaccatgcccatc
28921 cactcagaga tcactcaaaa tcccattacc ctattttatt tctccatcatatgtatcact
28981 atctgaaact atcttgttgt tgatgcaggc tattttcttg accccttcatgggactccca
29041 acaggggtac cccatttact cagcctgccc tgctcaacct cttgcaggagggagcacacg
29101 agtgaacgag tgcaggaacc agctggctgc tttagtgctg tgaggagtaaactccatgca
29161 ggccctgcag cagcaaccag gtaggggtgc ctgcaacccc agggccccagagggtgtgtt
29221 acaatgctct cgtagctctg ccatctgtgg acagcagtgt gttgtcagctcagtgggccc
29281 tttgcttcat catgtagggt ggctgccctc tgcctgtgag ggcaaagggccagggtgaca
29341 gtctttttgg gtacccacaa tttgtgcatc ctgaattctt gtttggtgcccaagaagaat
29401 ggggtcacac agatgaactg aaggatggtg aatgcagaga attagcaatgaaagtggctc
29461 tcagcagaga gagaagctga aaagggaatg ggaagggcag gtcactctcccctgaagtca
29521 agtcacatct ctccaatgtc cagccaccat ctctgaagtc aagtttcctctctctgatgt
29581 ccagccactt ctcctctcta ctggctgagt ctggggtatt tataggcagaggataggtgg
29641 tggggcaggc catacataat tttggaaaag gcaacattct attggtaaaaagacattatt
29701 cataaagaac caattgggaa agagcgggca cacagggatg gaagttctcactttgggctg
29761 caggtttcag gcttttcagc tcaaaagtga ggtttttcca gggacctgccccgtctgcct
29821 aaaatttcta cacttctgtc attgataccg ctggataaca gctctcctataaagttcagg
29881 ggcttaaaac aaaaatttac taattcaccc ggacagttct tgatagggtctctcctaact
29941 gttgcagtta catagcaact gggttggagt catcttttct gggcttgacatccaggacag
30001 cttcttccct tgtgtgtctg gtgcctcagt gctcctccag gcagcctttctctccagaag
30061 agtagcctgg acttcttggc aactcaagct tccaaaagaa aaaaaagcagagactgctgg
30121 ttctcttatc aaacaggcct ggaactggca caatgtactt ctgctgccatattcaggagg
30181 tcaaagcaat cgaaggccaa tccaagttca aaggcattgg agaaaaatgagaagtgtcac
30241 ttaaatgaga agtgacacat gcgtaaaagg gggaaaagca ttgattgtggccatttttgg
30301 agataagcta tcacgtttat ttgtttgttt gctttctaat ggtctgtcttctcccattag
30361 gttataagct ctgtgagaca acaggaatct tgtccatctt gttttatggctctacttcca
30421 acacctagaa taatgcctgg cacatagtag gtgctcagtg aataacttaagcacttgata
30481 catgtttggg gaactaaaat gaacagaatt aaacttcccc agattggtcctgccagattt
30541 gctgatgcca agcatgctga tgcctcacca gatgaaagaa gccctaaaatgtagggtttc
30601 gctttctctg caaacaagaa aaacttgccc tgaacacaaa atctagaaatagatttggcg
30661 tgttttctac attgaaatat ttcccgtagt accagaaatt attttcccacagctttgtgc
30721 tacattaaaa tattgaagtt gactgaaaat atctccattc tttaatcttggtgtagacta
30781 gaaacaattt ttttgtaaca aagtaaatat gaaaacttcc taatatttgaactccccaga
30841 tatccccaga tatctccaaa cttaaaatat cattgcaagt taagataaatttttttaaat
30901 gactaccgag aaaggtcatt aaaggcttgg ttattaaaat gtacagatttgggttataaa
30961 gccagaactt atttgtttaa atcattacat atgaccaagc acagaaaataaattacctca
31021 aatctcctct ttgctaattt ttactggtaa actctataaa atgatcctatctttaaacct
31081 ttttgtaaac cccttataag ttagtaagtg agaatgtatt catcagaaggattttagtga
31141 tgtttgaaat taaaaaagag agatttgatt tttaaaatta tacttgcagactactgctaa
31201 tgaaacttct tctaacccta gttttgtctt atcttcagtt tttccagatttgctcaaagc
31261 aatcccagtg agcatccacg tcaatgtcat tctcttctct gccatccttattgtgttaac
31321 catggtgggg acagccttct tcatgtacaa tgcttttgga aaaccttttgaaactctgca
31381 tggtccccta gggctgtacc ttttgagctt catttcaggt aagtacaaaattctacctct
31441 gaagacaaat gtgcttttca atatgtcaaa aagaccgtct acctaaatataaagttataa
31501 tcttaacata tatacatgga tgcacactgt agtattatac ataataacaaaaagtgtgga
31561 aataccacac ttgctcaaca gtagggaatt caataaatac tttatggacatctatatgaa
31621 taactgtgat gctgacatta aattatattt ttgaagatgt aatcaagaggataaacgctt
31681 gtctcaaaaa gttacatggg aaaagcagta tgtaaactta tataaacattgtgaacctaa
31741 tttgattata tatataaaat atagggaata tacatataaa atacatatatgtatatatgg
31801 gggctatata tatatatata tgaaagagat agatagatag atagatagatagatagatag
31861 acagacagac agacaataca gactccaatc tgttggtcgt ggttgtctctgacccatgac
31921 actatggggg acttttattt ttgctcatac ttttcaatat ttcttagtgttcaataatgt
31981 gctattattt atacataata ataaaaataa ataaatggca tcaaaaaagagtaaagggcc
32041 agtgttccgc ccacatatga gcagccatat tcaagcctgt agacactttgtgtagcctaa
32101 tgctaggtgt atctgggcaa ggataaactc taaagccaga aattagttcatcaataaaca
32161 tgtgctactc aatagctagg gctgatggaa aagaatataa aacccagtctgtgccaaatg
32221 gtgcttacta tctgcaagtg ggagaaggag aaagacgaga aaatgaaaaatgtgtgtata
32281 atttatatgt agctgttctg taggagatct ctgacttcac cccattctaactttgcaaaa
32341 agatccaaca ctttgtcaga ttcctgggag gcaagtaatt ttattgatggtttcatggag
32401 ggatacagaa cgataacaac tcacacaaag caaacaatgt aatgaaaatctctattcgac
32461 tgtttctttt tctcctgaag ttgccctttg gctgccagct accaggcaccaggctcaagg
32521 tactttcttg ctcttgacac tactcccttc tctcatacaa ttcaaccccaaccacaaacg
32581 tgtatagatc tctctctcta taaaacaaag gcctgtagtt aacaggaggtcacttgcagt
32641 gtagcctctg ttcattgtta cttgtgcaca ctgcttaggg tctcaccccatccacattct
32701 gctaatcaca ttattcaccc atccaatgta gatctctcca gtggagattctgctaatatt
32761 ttctttagat ttgtcacaag tatataatac agttttaaat tgtacagatgattatcctat
32821 aacagaagag tctaagcctt ttacatcttt gtatctctaa cgaaagcattcagcatgaag
32881 ctctgtacac agcagacaat tcaatatgaa tttgctgact tgaaacagcaagcctagaaa
32941 ggagatgtta acttggtcac ttagacagaa caggtttcag caatcagaattcagatgaca
33001 tggaactggt agaacaggcg ctttgaagca ataggacatg agccagtgaggagagggatg
33061 gaatatcata aacaaaggcc aagggctttg caatcagagc tgaagagccaagagcacagg
33121 ctcagggtgt gggcagactg aatgagaaag tgattcaatc acatgtgaaagtccagatga
33181 gaagagagag ttgggattac ttctgctcac caaacatcca aaaccaaacaggtggatccg
33241 ggtggtgtgc tgttttactg atgaccatta cacagaattt taacagaaggaatgtaaagc
33301 agtggttctc aaactggagt tcccagatga gcagcgtctg catcatctggaaacctgata
33361 aagcagcaaa ttctcaggcc ctaccccaga cccactgaat cagaaacttgggggtctggg
33421 ggaagatggc catctgtatt ttaacaatct cccttcagga gattctgaggctggctcaag
33481 tttgaactac aggtagttgg ttcaacaggt gttggtggac tgacaaacaaaaagagactc
33541 cgaggtaact ccaagatggt aatgtcagaa agcagctacc acccctagggcttgggggaa
33601 ccaacaaaag agtttggcat tgccagaacc tagaatcttg aggagaggccccagagcatt
33661 gtgtctcaga ccttgaggac ttggcactgg gacaccatga ggggtttctgggtgtgggaa
33721 agggctggaa actccccagt tgctgccacc agggagaact acaagtgaagtggaaggtgt
33781 gggcctttct cccttttctt ttctcgtctt ctctctcccc ctggtgctcatgtttgacag
33841 aaaacagctg aaaaggcaga actagtttgg ggagtcttga cctggcatcataaagcagag
33901 aaaagcaaag ctggagtgaa ggtgagacac aacagctcat tagcagcaacagccgtctag
33961 cgctccagct tctgaatgaa attctgaaga acagcgcact tggaagacaaattatttgac
34021 agttctgaca gacgaccaaa ctaacagcat ttgaaaagca agatgactcagagaatacag
34081 aatttaatcc aaatcccaga tcctatctct gcctttggcc aggcctaatgcaaggagaac
34141 ctgagcacac aaatatatgc aggaatgatc aggacctgtg cctgcattctattctgtctc
34201 acccaccttc aaatttgttg taaaaacatg ggctcaataa aggtttgtgaatcagggaag
34261 gaagagaagg ggagaaagga agggaaggag ccagctccag atctgtgtcttgcagaggat
34321 aaaggccagt gtttttagat cacccagtgt ttttctaagc ccccaatacttattttgaaa
34381 tatcaaaatg ttcaataact aaaaaaaaaa ccgttacaac aataaaacatgtttgagggt
34441 cagatggact ggcagtttgt gacctctggg gataaacagg tcactttggaatcacagact
34501 tcctcattcc ccttaaatct catatggtac ccagaagccc ttggaactttggaaggtgtt
34561 tattcacagt tgtaatgtcc atgcagaccc tggctctaag acccaattgtgtaagggtag
34621 gtttgtagcc cttatcccaa acattctaag tgtgagccaa tgcgtcacacactcagaggc
34681 cagagactgt attggggtcc tttatttcac gtacgagtca cattccattaagagacccca
34741 gaagtcagct ctcttccact gactggttct cttcccttgt ttctcttgccaatgtgtgct
34801 gcccaggtgg cagtgctcac tgtcagcaga gaagaaaaat gctttcctccttggacctct
34861 tttctctttt tctcctccct actcacattc aggttcccta agcttccccgctccttgtgc
34921 tgaagtcatt ctatggtcat ttcttcaact gtctacttcc ctgctggatgggcacccaag
34981 acttggcatc ctggggcatg tagaaagggg aaagggaagg gaagggaaaagaagtcctcc
35041 caattgtcta tctggacctt tccacactgc ccagagtact gctatgggcatctccttatg
35101 tctcccgatg tggtgcatgc cagaccctgc aggtagaaaa ggaaagaaagcaacccattg
35161 gaccaggcca gcaaaggctt cagtcacaca gctggctcat acttatggcttcatattctg
35221 ttgcctcttg aaccagacat ttcttccact ctcataacct ccagtttagctcgtattcct
35281 cagcattctc catgtaatat tgttgcatga aacccatgca agtcagccaatttgctcttt
35341 ctcatcttgt catttataaa ttgatgctga gaagtctttt tcccaaggtttttagtaata
35401 ccttcatcat cccccatagt tcattttggg cagtgattcg cttctttgactgtacattag
35461 aatcatctga agaactttct aaaactactg atctcaggtc tcacacaacactaattaaat
35521 tatagtctct ggtggggtag ggcttgggca ctgctatttt accttaagctctctggagtc
35581 attctaattt gtagccagtg ctaagggttg caatataagt gaatatatttcacgtatttg
35641 tcaaacattg actgagtgcc cattatgtgc cagccattat aataggcactggtgatccca
35701 cagtgaatca ggcacacaat gctgtcttca cggagcttgt tgtctagtgggagagtcaaa
35761 caaaagtgta tatcaataat taagtgatta cagattgcaa taattacaataagggtgata
35821 aacaggttgc tataatatac aatagtattg cctttcacca gacatttcttaaagaggtaa
35881 atcatctatc agacaccttt taaaaatctc atctaatttc aaaagtgtacataaataatt
35941 aagtgattac agtttgcaat aattacaatg agggtgataa acaagttgctatgaaagaga
36001 aagatagcag agatctggct ttgagatggt ggtcagggaa gactgctccaatagctgagt
36061 tctaaagcta agaaggaact gagaaccttc acagaacgtcccaagtagaagagaaagcac
36121 actgaagact ctagggaaag aggtctgctt gttgtaggaaccgaaagaaggccaatgtgg
36181 ctaggtgctg ggtagtgagg ggaaatggca caaggaaaaaatgaggttagagagatcagt
36241 tgataccagt taatgttgga ccctaaacat taaccatggt aagtcttttagaattgattc
36301 taattgcaat gaaaaccttt tgaaagattt taaaaagata tctgatagctgatttacctc
36361 tctaagaaat gtctggtgaa agacaatacc atcacattgg agatggaaaaagatgaatgg
36421 attctaaaaa cattctgaaa gtacattcaa aatgtttttc aggtagcttatgcaactaat
36481 aaatagtggt ggcattctgg gtaagacaag ggaggagcaggcttgcagtttagggcaaga
36541 aaggggtggg gagaagagct cagcactaaa atcatgtgtt ccatttggggcacatcgagt
36601 ctgagttgct atgagaccac caagtggaga tgccaagtaa atagtcagttacatgaatct
36661 ggagttcagt gaagaggtct agaagaaaga tgtatatttg ggcattattcggatatagat
36721 attatgtaaa gcaataaaat tggatgagat cacctaggga gagaatgcacatagataaaa
36781 actgacctag gaccacttca tgtctaaaac accaaaagca atgtcaacaaaagccaaaat
36841 tgacaaatgg gatctaatta aactaaagag cttctgcaca gcaaaagaatcagagtgaac
36901 aggcaaccca caaaatggaa gaaaattttc acaacctact catctgacaaagggctaata
36961 tccagaatct acagtgaact caaacaaatt tacaagaaaa aaacaaacaaccccatcaaa
37021 aagtgggtga aggacatgaa cagacacttc tcaaaagaag acatttatgcagccaaaaaa
37081 cacatgaaaa aatgctcacc atcactggcc atcagagaaa tgcaaatcaaaaccacaatg
37141 agataccatc tcacaccagt tcaaatggca atcattaaaa agtcaggaaacaacaggtgc
37201 tggagaggat ctggagaaat aggaacactt ttacactgtt ggtgggactataaactagtt
37261 caaccattgg ggaagtcatt gtggcgattc ctcagggatc tagaactagaaataccattt
37321 gacccagcca tcccattact gggtatatac ccaaaggact ataaatcatgctgctataaa
37381 gacacatgca catgtatgtt tattgcggca ctattcacaa tagcaaagacttggaaccaa
37441 cctaaatgtc caacaatgat agactggatt aagaaaatgt ggcacatatacaccatggaa
37501 tactatgcag ccataaaaaa tgatgagttc atgtcctttg tagggacatggatgaagctg
37561 gaaaccatca tcctcagcaa actatcgcaa ggacaaaaaa ccaaacaccgcatgttctca
37621 cccataggtg ggaattgaac gatgagaaca catggacacg ggaaggggaacatcacacac
37681 tggggactgt tgtggggtgg gaagaggggg gagggatagc attaggagatatacctaatg
37741 ctaaatgacg agttattggg tgcagcacac cagcatggca catgtatacatatgtaccta
37801 acctgcacat tgagcacacg taccctaaaa cttaaagtat aataataataaaataaaata
37861 aaataaaaaa acaaaaattg atgtaggacc aattcctgaa gaacactgacagttaatttt
37921 ttggtttagg aggaggagaa gccagcaaac gacactgagt agcaatatccaaagaaaaag
37981 aggaaaaagg aaaactggga gattatgagt gtcccagagg gaatgtttcaagattaccat
38041 cagcagtgag ctttgtgtaa aggtggcctc ctgtaataga ggtgcgggcaggagaaggca
38101 gaatagggaa aagggggtga aaaagcttcc ctcaagattt ataatacagtggaagagaga
38161 gacagagaga gagaaagaga aagagagaga gagaacttaa ggaggtagaggaagagagag
38221 aaccaaaaaa gagggagctg agtatagaag caattagatt catagtttttagttgcggca
38281 gtgatatttg agtgggggcc ttttatatat tccattctag gtgtttcccagttgatggga
38341 gagggtctta cctagatctg catgtaaaag ggagtaggcc agctggcagacttgacatgg
38401 atcagtggta gaacatccta gcagttctgt gaatactctc tgagaatgacatgaaaggta
38461 ttggttcagg ccttttggag gtgataaaaa ccaccaaaat gtggacttattgcaaattgt
38521 atttgttacc atttgcaatg attataatta ttctcttata tataggctttcttacatata
38581 gcttctctta cacatagcgt catgagttat gccttctctt acatatagtgtctgctatga
38641 gttatgccaa gcagggcaaa caaaattgct gcctttcttt aaaaagaggacgctcctagt
38701 atgggcctaa ttaattatga taattacagc tatggcatgg aacataagcacattcatata
38761 cacaaagaca ataaaataaa gaacagttca aaaacagaac agttacattatatatcagtt
38821 tcagtatgaa taataccctg gactctgaaa tatgtctggg gcacattattctgtaattgg
38881 tggtgaaaaa aaatctgcat cttatctcta cgccaatcct tatgaaggagctgtttttca
38941 ggagttcgag aaagagacac agggatgtcc agtcatcaaa gccgcagagcctgaggaaga
39001 ataaaggatt tgtggcagga aaacccagta atgaatgtat tctgctagtttctcagcata
39061 gaacttagaa aagaggccac agaaggaaaa gagaagtaat gttagacagctgatgttggc
39121 aatgggcaaa gaatttcatt ctcatatgca gggcagtggc taaaggggcagtgttgtgag
39181 gaatcacatt ccaggtcatt catgtccagg gtgtggtagg aggactgtgtttcatttatt
39241 ttgtacatgg cccagctatg accttgtgca aggaaatgct taatcattttctatcacagt
39301 tgcaaagaga ttcttatcct actcagaatg tacgtcttct cttctgtttcatttacagtc
39361 acaacccaag tccttgcttt gacctccaaa gcaccacttg atgtatccacttcagaaaca
39421 cacacagaca gctcacctct ttctatccct taccttcctc ccctcttcactcaaaccacc
39481 tacttccttt gcattcactc ttccttcagc ctgaaataat cttcctccaaatatctacct
39541 tctcactccc tcacttctct caagatacac ttaaatgtta tattccctatgaggcctccc
39601 ctggccatcc ctccccagcc ttcctatccc ccctctctgc tttattttattctccttaat
39661 atatatcaca ctctgataaa ccattgaatg tacttatcaa gttattgcctctctctccct
39721 ttccattgtc tccatcactg agagctctgt gaagaaaagg atttgtacctgtttcattta
39781 gtgctgtacc cccagttccc acaacagcgc aacaggcact caataaatagttgttgaata
39841 agtgaataaa acagaagtag ctgcatattt tctggtaaca aatgatattcttctgaaaat
39901 gtcatatttt cagacatatt tccgaaaata aattcaaatt agataaacattgtattttta
39961 gaccatttct tctttgcatt aatcatcctt ctcaataata taacatttgtaaaacttagg
40021 ttagatatgg gctcttcaac tttccattac agaagataaa gtgaaaaggctagacccaat
40081 ggtgttattc cttcatctac atctatcctt tggaaacaca tgaccaaattgcttgccatc
40141 acaatctcaa aatctaccct ttggtattaa ctcacttcac ttgtccctctgtcccttttt
40201 agatggtagc catcggtctc tggagcagtg tagagtcaga acaacttctatttggggaag
40261 aaatcattgc tggtgacctt actttcaatt actaactttc tagtgacatttacataattt
40321 tagagaaaat taacacctac acttgtaaag ttgtggcttt cccacacctatttatcatct
40381 ctcaatattc cttgaaaagg aaattatcaa tttatcattc tatattggcaatgaaatgcc
40441 cctaatatct gtcacctata agacaattga agatgatgtg ttgaaagctttctgaaaatg
40501 ctgatcatta ctttaaatgg aattgaaatt ccagtttatt atttccaaaaatatgatctt
40561 actgatcata ggataacatt tcataacatt tcagagattt cttccccttcgaggagccaa
40621 acccatagga cctctggact cccacagatc ctggcaggga gttcccactcataaaagcac
40681 aggtgccctc agagtcattc agggatgaag aagcaaccct cattggccatgtcctacgtt
40741 ccccatatag taaggactgg aggagaccag tgctcaattc tgcagtctcagacagctgtc
40801 agaggagagt catgaatgtg cagtgtctag cacattacaa acgtttgttaattgactgat
40861 cattcatggt gtgacagccc tataactcag ctatcctatt cagtcagaaattaactcagt
40921 aatcaaagtc attaaaagga agaaaaaaaa aacctacagt accagacagatggtggggaa
40981 atcagacaga tgaaaggaaa aatggctgta ggtcattgag taagacactgggcagcaaaa
41041 cctgggcctt gtgcctggtt atactccaca ttatagctcc agcaaggtttggcaggattt
41101 ccacagtcct ggcttattct aacctttctt gggagcagga gcagtgttggtcagatagac
41161 agacacataa ggaatctgtc caactggcac cgtgtgaatt tgggctcttggtgtacatgg
41221 ataactggga aaaagaggag agagacatgt aggactgatc ctaccgtttgtgaagtcttg
41281 ggcaagagta tgaatgaaaa cccacttctc ttcccctgcc tggctccactgcacacagta
41341 aagagcctca agcataggtg tgtggacatt gcaccatgta tccaagctctgaccatgcct
41401 cttgaaacag ctattcctca gccaccctct gaccatggga ggaatgacccaggagaaatg
41461 accacatagg tcttgaaaat gggctcaggg ctatttacga agtcaattccggggtcccag
41521 gagtatggac taaaatgtga gtcaggcatg ccagatgggt atgttctattgacttcaagg
41581 attcctcatg ctgtgggaag gaacctctcc agaagagaga cagagcagaaccctctaaat
41641 gtggggcaca aagcaggagc ccctcttgct ggattcaaag ggtcatactggaagagtgta
41701 ggttgagtct tattctcaca tcactcatat cacttacaca cttcttttatagccttagca
41761 gccatgccac aaagagaaac tcttcatgca tatcttttgg tccataagtcataaatagtt
41821 atccttgatc ccatgtcttt tttagagcca tggacagaga gaagcaaaaatataccaagt
41881 tcacactgag ttgtctccct tcatatctct tagcagtcac tgaaaggttatgagactcag
41941 gctgggtttc tatcctctgt ccctgaaacg acaacgttga cctcgtgatcaaccctagaa
42001 tccagagcaa gatctcagac tgtcctctct actaccagac agcacactttgttttggggg
42061 ctgtgtgctt gaaatattag ctatggcaaa aggctttgag tcttatgacaccccaagtaa
42121 cttttacttt aggaatttga aatacagcct tgctgtaatg ctgtctccttaacaaagcag
42181 tacctttgaa atatttaaca acttgaaaag gaaaccgagc ttgaattttcctttcaggtg
42241 ctcaggaaat aatgtttcac ttctgtctga aattcaccat ctcctcagacaaagaaggct
42301 cttatggtaa aaggaatggc attttctcca caattttcga ataaaagataaagagaaaac
42361 agcactgcag cctttttgtt aggatctaac aataaagaaa taatacggttttgccagggg
42421 agagctctgg ttttaagctc agaatacaaa aataggctga caaaattttacaaaggaata
42481 ttctcagcta ccactctgag gatggtagaa agtgaaattt caagaaaattatattatttg
42541 attatttgat gatgattaag ctgattggcc agtcctatgt gaaattctaaagtagaagaa
42601 atgtgatgtt gtcttttctg ctcacctctc ccctcattcc tacccccaaatctctgcctc
42661 taccccaaac ccagcctgac ctttgggaaa ggaatggggg ctgtcacttgcaccgtagct
42721 cctcctgcct gcagtactct ccccccacag tccagcctcc ctctgctcagctaacttttc
42781 ctatagctcc ttctggctac ttctaaggaa ccttccataa tgctgcccaccctctcagta
42841 acagcccctc tactatccct tgattacatg cactgtaatt ggttagtaattgattttatg
42901 tcctctgcca aattatactc catgagagca aaaatcatga gtattatctttaatgtttaa
42961 atctccacaa ctatccccca tataagtcta gagaataaat gaatgagtgaattaatgaat
43021 agaaactcaa gccattatgt tgccactcct aggatatttg gattaactttaactgaagag
43081 taaaaagcat ttacctgtcc taaaggagac ataaaattag tgggagagtatttggagaaa
43141 aaaaagacac tgtaatacat tcttttgtgt tgcctaccct gatgtagtcaggtgtccctg
43201 atatggggtg ggctgaggat ttgaaataaa atacctaatt tgacattgtaagtggaggaa
43261 tcaggatttg aaaccaaatt ggtttgacct aaatcaagct attatgataaggacttgcaa
43321 gaaaaaagga atccataaaa accatatgaa tagctaccaa ttagtaagcatttatatgtg
43381 tcaattacaa agccaaatgc aaatcatgct ttatttatat tagccaccttttatagatga
43441 agaaattgag acctgaatat taaaattgcc tacttttaca tagtaagtaaaggaatcagg
43501 gtttgaaccc aaattggttt cacctaaggt agaaaaccat cccagcaagtctcctattaa
43561 ctggaaccct attgtggtgg cctgagatat aacagtagct gtggaagcgctgtagagtcc
43621 tggccatcct atgtgctcct gatctggtcc ctcctgccac ctgcttctgctccctgtgcc
43681 atccacccat ctggaagtct cccagtgtcc atcttcgggg gagacactcaccagagtttc
43741 cagcttccag ccagtatgga gtgcccctgt cccacagcaa tctcaccgaaatcacagcta
43801 catctgttaa aattaggcta ccaatgagtg atagatgagg gggaaaaataataatagtgt
43861 actaaacaaa acaaatgttt atttttctca cacataaaaa tctagaggttgaagtccagg
43921 gctggtccag aggctccaag gatctgggat ttagactccc tctttcttgtttttccacag
43981 catatggctt ccatttctgg ggccacattg gtccaaaatg tatgctggggctccagccat
44041 tgcatccata tttcagccac aggaaggagg aagtggggaa gaaaggacaggcccctaata
44101 cctgtatagt tcaagaagac tatcccgccc atacttccca accacccttagttgaacaat
44161 gctgtcttaa ttcaagacac tcacatgtct agccaaaaat ctgaattctgttacaaacaa
44221 ggagaataga gatgtgcgcc acctcaatac ctcatccata gctaccttttcctttgtgca
44281 gctgtggcca agtgaaagct gaaggagctg tggtaaccct tctgaagggaggctggggcc
44341 tttcacaaga ggctgcatga ttgacattta tcctgcatgg cctgtgaagtacagagaaat
44401 attttctctt gaagccacat catagcagtg gctgctttgt agcctgattccaccattatg
44461 cctttaaagt gcctagcaat tcagccttca catcatgcaa agaggaatatctcccagtct
44521 ttgtaagatc agcttaattc taaccacctc cttacctccc actgcactcctacacgcaca
44581 cacaaatctt cttcactcag agcagaacca taacccaagc cctaccacctagagactgaa
44641 gaatcaggct catgattaca aatatgcaat aattttttgt gtggataatgtcaatgggga
44701 tgatggtaag agaattcctt ggtttacaca ttgaccctct tccctgtcccttacaatcag
44761 gaaatatttg tcccaacacc ttgtttcttc tgttgcaggc tcctgtggctgtcttgtcat
44821 gatattgttt gcctctgaag tgaaaatcca tcacctctca gaaaaaattgcaaattataa
44881 agaagggact tatgtctaca aaacgcaaag tgaaaaatat accacctcattctgggtcat
44941 tttcttttgc ttttttgttc attttctgaa tgggctccta atacgacttgctggatttca
45001 gttccctttt gcaaaatcta aagacgcaga aacaactaat gtagctgcagatctaatgta
45061 ctgaaaggca aacctttcta taattttaca agggagtaga cttgctttggtcacttttag
45121 atgtggttaa ttttgcatat ccttttagtc tgcatatatt aaagcatcaggacccttcgt
45181 gacaatgttt acaaattacg tactaaggat acaggctgga aagtaagggaagcagaagga
45241 aggctttgaa aagttgtttt atctggtggg aaattgcttg acccaggtagtcaaaggcag
45301 ttgactagaa tcgacaaatt gttactccat atatatatat gtgtgtgtgtgtgtgtgtgt
45361 gtgtgtgtaa gatgtcttcc tatcaaaaag atatcaaagg cacatggaatatattttaat
45421 aaaaacaaat aatatctcta atatatccac acatttgttg ccagatttcagaaaactgag
45481 ctgcaatcgc tttcctaaaa cagtagtgta ttaaatgaac atctataaaatgtatcaaca
45541 cacattttaa aaaatttgtt taaagtatac tcttaggcca ggcgtggtgactcacacctg
45601 taattccagc acttcaggag gccaaggtgg gaagatcatt tgagttcaggagttcgagtt
45661 acagcctggg caataaagtg agaccctgtc actaacaaaa ttaaaaaataaaataaatat
45721 aaaatatagg ctttaaaaaa gcatagtctt attaaccatg tctgttggtcaaaatctgca
45781 aactctaaaa gaagaaaaga agaaaaaacc aagcttaggg tatttttcctcccgtgcctg
45841 agtcccaatt acattcacga cagtactttc aatgaacata attgttaggaccactgagga
45901 atcatgaaaa atgatctctg cttagtacat ttgatgcaaa atgacttattaggggctgtt
45961 tttctagcta tagtgtctcg agtactaata tgcaattatg aaaattatattaaatctggg
46021 attatgacgg tatcactgta tcatcttggt cttgttctgg ctgtcaccaagcatgaccca
46081 ggtcaacttt ttttttcccc tgaattaccc atcaaattga tctgcagctgactaaaggcc
46141 acagctgagc ctggaactga cccttccttc atcctcaacc tgctgtcctccagaaagcac
46201 caaggaaaaa gcagagaatg acagcaaaca gatcactagg cctctgaccacaggtgctga
46261 gtactcagca gccctcatat aataggtttg aaagtactcc ttaaaataaaacactgtttc
46321 cctttggaac tatttacaag gatgaaacaa ccgtatacct gagaaataacttgctctggt
46381 gtcaattcgc tattcgccag cagacatcag aacacaccga gtttccagatgctggttttt
46441 ccccttaaat caggaaatac acctggacaa tttctagaag actacaattcagtctagcca
46501 caaaggggat tttttttttt tggtaacagg ctagagcccg gttctgtaagtctttagctg
46561 aaatggtcca gtacaaaagc actggaaatg agtgggctag gaggacaaggaccgtctcct
46621 gcgtgaggag ttggttggag gtccccaagg ccaggtaccc cctgcactcttattggattc
46681 ctctctgtct tcttggagtt ttgaaaaact ccttcgaaca ccaggcttttttctttagaa
46741 aacaagtctc caatcgttct ctgttccgta gaaagagaaa gaaaacctggagcagctgct
46801 gaaaaatcta atgaggaact aagaggcaaa cccacca
人野生型CLRN1基因组DNA序列的非限制性实例是SEQ ID NO:47。SEQ ID NO:47中的外显子是：核苷酸位置1-544(外显子1)、核苷酸位置28764-29180(外显子2)、核苷酸位置31239-31418(外显子3)、核苷酸位置32481-32519(外显子4)、核苷酸位置44799-46433(外显子5)、核苷酸位置44799-44935(外显子6)和核苷酸位置46128-46837(外显子7)。内含子位于SEQ ID NO:47中的这些外显子的每一对之间，即在核苷酸位置545-28763(内含子1)、核苷酸位置29181-31238(内含子2)、核苷酸位置31419-32480(内含子3)、核苷酸位置32520-44798(内含子4)和核苷酸位置44936-46127(内含子7)处。
跨膜通道样1(TMC1)
TMC1基因编码“跨膜通道样1”(TMC1)。TMC1是钙依赖性氯离子通道，并且可与毛细胞的硬纤毛蛋白中的跨膜O-甲基转移酶同系物相互作用。TMC1中的突变可导致非综合征性感觉神经性听力损失。例如，TMC1中的D572N突变已与耳聋相关联(Kurima等人，Nat Genet30:277-284,2002和Wei等人，J Transl Med 12:311,2014)。
人TMC1基因位于染色体9q21上。其包含24个外显子，涵盖约314千碱基(kb)(NCBI登录号NG008213.1)。从人TMC1基因表达的全长野生型TMC1蛋白的长度为760个氨基酸。
示例性人野生型TMC1蛋白为或包括SEQ ID NO:48的序列。编码野生型TMC1蛋白的核酸的非限制性实例为或包括SEQ ID NO:49。
在本文所述的任何组合物的一些实施方案中，所述TMC1蛋白包含与SEQ ID NO:48具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
人TMC1蛋白(SEQ ID NO:48)(NCBI登录号NP_619636.2)
MSPKKVQIKVEEKEDETEESSSEEEEEVEDKLPRRESLRPKRKRTRDVINEDDPEPEPEDEETRKAREKERRRRLKRGAEEEEIDEEELERLKAELDEKRQIIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKRWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWMNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNKFNSITMNFKEAITEEKAAQVEENVHLIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNASFSENSTGPPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDLKKKMKMQALENKMRNKKMAAARAAAAAGRQ
人TMC1 cDNA(SEQ ID NO:49)
atgtcacccaaaaaagtacaaatcaaagtggaggaaaaagaagacgagactgaggaaagctcaagtgaagaggaagaggaggtggaagataagctacctcgaagagagagcttgagaccaaagaggaaacggaccagagatgttatcaatgaggatgacccagaacctgaaccagaggatgaagaaacaaggaaggcaagagaaaaagagaggaggaggaggctaaagagaggagcagaagaagaagaaattgatgaagaggaattggaaagattgaaggcagagttagatgagaaaagacaaataattgctactgtcaaatgcaaaccatggaagatggagaagaaaattgaagttctcaaggaggcaaaaaaatttgtgagtgaaaatgaaggggctcttgggaaaggaaaaggaaaacggtggtttgcatttaagatgatgatggccaagaaatgggcaaaattcctccgtgattttgagaacttcaaagctgcgtgtgtcccatgggaaaataaaatcaaggctattgaaagtcagtttggctcctcagtggcctcatacttcctcttcttgagatggatgtatggagtcaatatggttctctttatcctgacatttagcctcatcatgttgccagagtacctctggggtttgccatatggcagtttacctaggaaaaccgttcccagagccgaagaggcatcggcagcaaactttggtgtgttgtacgacttcaatggtttggcacaatattccgttctcttttatggctattatgacaataaacgaacaattggatggatgaatttcaggttgccgctctcctattttctagtggggattatgtgcattggatacagctttctggttgtcctcaaagcaatgaccaaaaacattggtgatgatggaggtggagatgacaacactttcaatttcagctggaaggtctttaccagctgggactacctgatcggcaatcctgaaacagcagacaacaaatttaattctatcacaatgaactttaaggaagctatcacagaagaaaaagcagcccaagtagaagaaaacgtccacttgatcagattcctgaggtttctggctaacttcttcgtgtttctaacacttggagggagtggatacctcatcttttgggctgtgaagcgatcccaggaatttgcacagcaagatcctgacacccttgggtggtgggaaaaaaatgaaatgaacatggttatgtccctcctagggatgttctgtccaacattgtttgacttatttgctgaattagaagactaccatcctctcatcgctttgaaatggctactgggacgcatttttgctcttcttttaggcaatttatacgtatttattcttgcattaatggatgagattaacaacaagattgaagaggagaagctagtaaaggccaatattaccctttgggaagccaatatgatcaaggcctacaatgcatcattctctgaaaatagcactggaccacccttttttgttcaccctgcagatgtacctcgaggaccttgctgggaaacaatggtgggacaggagtttgtgaggctgacagtctctgatgttctgaccacctacgtcacaatcctcattggggactttctaagggcatgttttgtgaggttttgcaattattgctggtgctgggacttggagtatggatatccttcatacaccgaattcgacatcagtggcaacgtcctcgctctgatcttcaaccaaggcatgatctggatgggctccttctttgctcccagcctcccaggcatcaatatccttcgactccatacatccatgtacttccagtgctgggccgttatgtgctgcaatgttcctgaggccagggtcttcaaagcttccagatcaaataacttctacctgggcatgctactgctcatcctcttcctgtccacaatgcctgtcttgtacatgatcgtgtccctcccaccatcttttgattgtggtccattcagtggcaaaaatagaatgtttgaagtcattggagagaccctggagcacgatttcccaagctggatggcgaagatcttgagacagctttcaaaccctgggctggtcattgctgtcattttggtgatggttttggccatctattatctcaatgctactgccaagggccagaaggcagcgaatctggatctcaaaaagaagatgaaaatgcaagctttggagaacaaaatgcgaaacaagaaaatggcagctgcacgagcagctgcagctgctggtcgccagtaa
人野生型TMC1基因组DNA序列的非限制性实例是SEQ ID NO:50。SEQ ID NO:50中的外显子是：核苷酸位置1-113(外显子1)、核苷酸位置56102-56223(外显子2)、核苷酸位置94568-94677(外显子3)、核苷酸位置106121-106263(外显子4)、核苷酸位置126797-126864(外显子5)、核苷酸位置166909-166956(外显子6)、核苷酸位置172743-172914(外显子7)、核苷酸位置178718-178843(外显子8)、核苷酸位置218319-218409(外显子9)、核苷酸位置220644-220725(外显子10)、核苷酸位置230050-230156(外显子11)、核苷酸位置232986-233084(外显子12)、核苷酸位置250613-250755(外显子13)、核苷酸位置266539-266683(外显子14)、核苷酸位置267323-267517(外显子15)、核苷酸位置270086-270265(外显子16)、核苷酸位置270391-270552(外显子17)、核苷酸位置283582-283710(外显子18)、核苷酸位置294343-294410(外显子19)、核苷酸位置299042-299281(外显子20)、核苷酸位置305069-305194(外显子21)、核苷酸位置308651-308729(外显子22)、核苷酸位置308831-30882(外显子23)和核苷酸位置314151-314551(外显子24)。SEQ ID NO:50中的内含子是：核苷酸位置114-56101(内含子1)、核苷酸位置56224-94567(内含子2)、核苷酸位置94678-106120(内含子3)、核苷酸位置106264-126796(内含子4)、核苷酸位置126865-166908(内含子5)、核苷酸位置166957-172742(内含子6)、核苷酸位置172915-178717(内含子7)、核苷酸位置178844-218318(内含子8)、核苷酸位置218410-220643(内含子9)、核苷酸位置220726-230049(内含子10)、核苷酸位置230157-232985(内含子11)、核苷酸位置233085-250612(内含子12)、核苷酸位置250756-266538(内含子13)、核苷酸位置266684-267322(内含子14)、核苷酸位置267518-270085(内含子15)、核苷酸位置270266-270390(内含子16)、核苷酸位置270553-283581(内含子17)、核苷酸位置283711-294342(内含子18)、核苷酸位置294411-299041(内含子19)、核苷酸位置299282-305068(内含子20)、核苷酸位置305195-308650(内含子21)、核苷酸位置308730-308830(内含子22)和核苷酸位置30883-314150(内含子23)。
人TMC1基因序列(SEQ ID NO:50)(NCBI参考序列：NG_008213.1)
1 cagaaactat gagggcagaa cccagcaatc tgtgctttct ttcacaagcc ctccaggagt
61 tgctgaaatt taggaatcat tgccccaaaa agtggccctc ataatgatgc caggtaagga
121 aagacaacat tattacctat gtgtggtgtg ttaacattct ttatgaaaca tgtgtgaaga
181 cctaaatcga agactttctc catgagatat tccctaatca cattagtgaa ataaaactat
241 atttcctcta cttttctact gctacagaaa tctcccccag ttaggatagt cccagtttcc
301 tatttatctt tgtttttctt gcagtgcaca gcatgtcacc cagtaattga taagtttttt
361 tttttttgag acggagtctt gctctgtctc ccaggctgga gtgcagtggc gcgatctcgg
421 ctccccaagt agctgggact acaggcgccc gccatcacgc ccggctaatt ttttgtattt
481 ttagtagaga cggggtttcg ccgtgttagc caggatggtc tcgatttcct gacctcgtga
541 tccgcccgcc tcagcctccc aaagtgctgg gattacaggc gtgagccacc gcacctggcc
601 taattgatat gtttaaatgt taaaattaaa tgcaatgatt tcctaaaata aacaaatgtg
661 ggacaattta ttgcactctg ttcaaattcc cattttgaag tggaattcaa acaaacatga
721 cagtaaaggg ggacagtgag cacagggaca agagaaaagg agaaagggaa gaaatacaga
781 gaactagata ggaggaagtg tcaaagactg atgggtgtaa gccaccttta cctctggata
841 ttggttttcc tttgaattgt ggtatgtggt catattgctt attagttata acatacagct
901 gtcagaagag tttttcaatt aaaatttcaa atgtaatatt aaaactgttt ggattccttc
961 ctactgggca ctggacactg tctgtggagc tgctggaaca gcgctgaata gggtcatatt
1021 ttaaaggaac tcagcctagt gcagtttctc aaccttagca ctattggcctttggggcctg
1081 ataatccttt tttgtgaggg gctgtcctgt gcactgtagg atgtttagcagcatccttgg
1141 cttctactca gtagatgaca gtatcaaccc ccttccccag aagtgacaattaaaaatgtc
1201 tccagacttt tccaaatgtc ccctgaggag caaaattgtc tccagttgaaaaccactggg
1261 ttagtgggag aaacagataa gacagaagtt ctccatacac catgataatgccatgatgcc
1321 atagggctgg caggagtgaa gggaagagca tctcacaaag actcggggggatgcagggag
1381 gaggaaaaat taggaaatga agtgggctga gttgcagtta gcctgtggggaaaatgaagg
1441 agaagggata aggaagaaga ggaggaagga gggaggaaga gtgaggagtaatagggaatt
1501 atagttgacc ttgaacaact tggggtttag ggatgccgac ccttgcgtagtcaaaaatct
1561 gagcttaact tttgactacc ctcacacttt cctaacagcc tactgttgaccagatgcttt
1621 accaataaca taaacagttt attaacacat attttgtatg ttttatgtattatacactgt
1681 attcttacaa taaggtaagc tagagaaaag aaaatgctat taagaaaattgtaaggaaga
1741 aaaaatatat ttactgttca ttaaggggaa gtagatcatc ataaagctcttcatccttgt
1801 catcttcaag ttgaataggc tgaaggagga gggggagaga gaagagactggccttgctgt
1861 cttaggggtg gcagggatgg tagaggtgca ggaggtggaa ggggaggcaggaaaggcagg
1921 cacactcggg gtagctttcg ttgaaagaaa tcttcatatg agtggacccatgcagttcaa
1981 acctgacttg ttcagagtca actgtacttg ttccaggcta agaacagagaataaaaaaaa
2041 aatgtataga ggcctgaaac agcatattat attaaaagaa ctcaaagccggtaaatgctt
2101 tgctactgaa gcataaagtg agaaaggggc atcatgggct ctgaaattgcagccacaagt
2161 ctacagaaca catttttcat agcccaaggt cagtcttcta ttaccctttgcagtgaggtt
2221 atcatcatcc attttcactc gtcagtgctg gggagcccat taaatacttgccactatact
2281 tggtcccaac agttaataga ctgtagcatc ttttatttct tcacctagcctgaaatcagt
2341 tgagcttttg cagaatctta gatatgtcgt ttttttcttc aggtttagaatggggcactt
2401 aaaaagatgc atagtacttg aaaatagaga aagaaaatag catgtagaaatttgtgcctt
2461 tattctgccc aaacgtctca aaaaggaaaa aaataatttt aagggtaaatattgtcatca
2521 atttatctga gctcttttga cttcctttga gcctgaaaaa caggatcagtgtctttttag
2581 tatttaccat agtgcctgat atgtagaagg tgtttgacca atgtttattagataaatgtt
2641 cacttttatt actagtaata ttaaccacat tttaatagag actaataatacatgataaac
2701 ttctcaagga tgcgatctca tttgatcact ataacaaccc aatgaggtaagcgaggaata
2761 gttgttaact ctaatacatg ttatatctta tccttgaccc agtattaccccagtcatgcc
2821 ttcctttccc tgcaatgaaa gaaaaccgat aaacacaaaa tgttgtatcccatataagca
2881 ttcattctta tggtagataa gtaaatggaa aagataggta tgcattctcaatttttttaa
2941 gtcctagaat tataaaacag taaagaagtg agaagagaga gaaatcttaagggaccaacc
3001 tcttgatttt acaggtgaga aaactgaggc cacatagcca tttagtgcagagccaggatt
3061 ataaaccaga tgtttggaat cctatgtggt ggtggacacg aggatatactaattagcgtc
3121 gttaccggaa aattccacat atctctaagg agcagatcac cacacacctgcacagcccaa
3181 gcctggattg tggaggtttt tcttgtagag tttgtctttg atagaaagatacggtccaga
3241 aggccggctt caaggacata agaaagggca tattcaaaac aaatacatgtatgcctattc
3301 ttttaaaccg gtacttaaca atagtatcca ggtgtccaaa tataatagcttatctgtttt
3361 attttttcca gaaaaggaaa caaggtctta gagaggttac attttgcataggattttgtt
3421 agccaagtca gcatctgttt gcatcttaaa aatgagtcat acctattccttgtaagtagg
3481 acaggagggc agctggaatt tcccagctca ctccttgtca ctgcttcctgcctctgctgc
3541 tctttgtcct ccacagcacg cttcattggc taaaaagtga accagatactacattacctc
3601 agggcagttg taagtactga gtcagatgcc ttaggcttgt gtgatgggaagtttagggcg
3661 agaccaatgt cttgctttaa caacagtgtg aataagttaa tttcttttgagattttatta
3721 ctcaatattc cacccagaaa gaaacacaga tgacactcag ccaatcaaaggccatctggg
3781 actgacaaac gcagagcttg ttgtagatga caaggctcag tggatggatcatcactgaaa
3841 gaaagggaaa cagtttgaac tgttgtatct ctctccttgc tcacatgaaaaacaaaaaaa
3901 tccttggcca gttgcggtgg ctcacgcctg taatcccagc actttgggaggcccaggcgg
3961 gcagatcact tgaggtcaga agttctggac cagcctggcc aacatggcaaaaccccgtct
4021 ctactaaaaa tacaaaaatt agccgggcgt ggtggcacac acctgtattcccagctactt
4081 gggaggctga ggcatgagaa ttgcttgaac ctgggaggtg gaggttgcagtgagccaagg
4141 tcgtgccact gcactccagc ctggatgaca gagtgagact ccgtctcaaaaaaaaaaaaa
4201 aattccttaa ccacagacta agtaagcatt attgcacaga gtgtcattcgctaatcttgc
4261 ttgtgcctga actttgaaag caccagcccc ttgctttggg ggctgggggcgtggggtgta
4321 agtgtgtgtg tcctctagaa gaagacaaca ctgagaacag aaggagaggatcttggagat
4381 ttgttaattt cctattgcag ttagccttgt ctggggctct cactttagcacttaaaataa
4441 catactcctt tgcacagatg ttattttttt ctcttcatgt gtacaacttgaattatccaa
4501 tggccttgct ttgaggatat tcatcctatc ttattgatcc tgtcactgtgtaggacaatg
4561 gagaacacag taaaaaaccc tcaatggata ctacttacac taaattaactctatgaattc
4621 aaaatttgaa gatgctactt aatcatgtaa gcctggttct ccaaaacttcatctgccatg
4681 ggaaaaatca aagcttgtaa aatgattaaa cttgtaaagg aattaaactctaggattcac
4741 tcattttata attggtattt tcaccctaag agctttcttt ttcctctctggtgtttaaaa
4801 acaaagtaaa accagacaaa acaagattaa ctaaattaaa acccctgtgactttaaaaaa
4861 tgtagccaag aataatgtgc aagtgtctag ttaggccaat agatatccttaacatacgtg
4921 agctgggaac acaaatgagc atgaagggca aggaagagca ccaccccctgcttcttttcc
4981 tgctcctgtt cttgcagagg gtcaggcttg gagaccacat atggtcagctcaacactcaa
5041 gtccaccaag cagcccatga ggaactcttc cttccagagt tgtgcacaccatgcagtgtg
5101 gtccacctgc agaagcacac aacaggcgct gcctgggcca gaggtccattcaggccatgg
5161 aattggtctc aatgccattt aggcatgaat ccagggtcct gggtaccagacgcatggtct
5221 aggtaggggg tgtcatgtac taggtgagca tggggttccg ctgggcatgttcccttgtct
5281 tgtaggatgt tagctctgag gggcgtggct ggaagaaggc tagccttgagccctctaaaa
5341 ggcagggctc agggcaaagc tcccagttgc tcaggcctgt gggtaatactgcttaaaaat
5401 ccccttgaga acttctttaa aatgcaaata tctcgattct tttgtagttcaaaagcatga
5461 tgattgggtg ttcacaggca tgtgtaagac gtgacaccct ctgaacctccttatgacccg
5521 gtacattacc tgtctgacct gaaaaaaaaa tgcaaatttc tggattctacccgcctcccc
5581 gcactccgac attacgatgt agcagctctg tggtaggatc caggaatctgcctgtgtaat
5641 cacaggttga tattctggtg tttcctggtt ttgctctgct gatttgggggatgtttacca
5701 gcaggagagc agcctctttc ctctgccctc ctcccttgct gccctccccagaccccagtg
5761 actcacgctc ctcctgctcc tcctgttgct ggcctctctg ttgtggttgccagcgctact
5821 ttgcagacgc tgcctgctcc ctgcacgcca acacagattc tgtttccctgcgaccgctgc
5881 tgctgttgtt tgttccgtcc ctggtttatt gtaggagagc tgattgttctgttgccactg
5941 ctaccaagct gcaaacacca ggctcacggt gcaaggggaa ggggcttctcctctgggtgt
6001 tctgcctcta tcgcctaggc tctcaggctt tgttgccaat ggcactgcgagaccctaaac
6061 tatggccttg tgattcccac atctccattt agttctttct tttgttctctaagatctgag
6121 aaggagccca tgtctttcag tgttcctgtt ttcttgcgat acttcccccctccccgactc
6181 cagaatttag ggcaaccttc tgctgtggtc tgaatgttta tttctctccaccccgccaaa
6241 cttatatgtt gaaatcttaa cccctaaggt ggtggtatta gaaactgaagcctctgggag
6301 gtaattaagt tataaggaca aagccctcat gaatgggatt actgttcttataaaaaaaag
6361 gccccagaga gctagctagc tccttccacc atgtgaggac acaacgtgaaggtgctgtct
6421 atgaggaagg gtccctcacc agacaccaat catctggcac attgatcttgaacttcctat
6481 cctccagaac tgtaaacaaa taaatttctc ttgcttataa accataagttcatgattttt
6541 tttttttttt tgagacggag tttcgctctt gttgcccagg ctggagtgcaatggtgtgat
6601 ctcggctcac aacaaactcc gcctcccggg ttcaagcgat tctcctgcctcagcttccca
6661 agtagctggg attataggca tgcgccacca tgcctggcga attttgtatttttggtagag
6721 acagggtttc tccatgttgg tcaggctggt ctcgaactcc tgacctcaggtgatccaccc
6781 gcctcggcct cccaaagtgc tagggttaca gatgtgagcc actgcacctggccaagttca
6841 tgatttttgt aattagcatc caaaatggac taaaaccccc atcctcctgaaggttctgaa
6901 tctgaggacc caagacttgg ctctcagcct taatgtcctg ctcccactattttcaggggg
6961 cccaatataa atttcctgag tttttgaggt ggttgggctt gcagactgacctttagtatg
7021 ccctttgtta catttacaaa atagattgct tacagggtta gacaaatacagttgaccctc
7081 tgtatccctg ccttccatat ccatgggtca aaattatttg gaaaaaaaaatgtgtctgta
7141 ttgaacatgt atagattttt tttttgtata tttcctaaac tatatcgtataataactact
7201 tacagagcat tcatattgta ttaggcatta taagtagtgt agttatgatttaaagtatgt
7261 gagagaatgt gcacaggtta tacagaaata ctacaccatt tttttttttttaatcaggga
7321 ctgaagcatc ttttcagcta tgactttggt atccggtggc gggtggggcggtgggtgggt
7381 cctggaacca ttcctccatg aataccaagg gataactcta attgctaaatcgtttcctat
7441 ttttgtgaac tggtaaagga ctgcatgaga aaggccaaaa attaaagaataatatgctta
7501 ttcaagcccg gtgtggtggc gggcacttgt agtcctagct acttggaaggccgagatggg
7561 cccaggagtt tgaggctata gagggctatg gttgcacctg tgaatagtcactgcacacta
7621 gctcgggcaa catagctaga ccctgtctct aaaaaagaaa aattctgctgtaataaacct
7681 gcacgcataa aatgatgtct atgtgtctat atagtgtgta tatacatatgtgtttaggaa
7741 atgtgtatat atgtgtgtgt gtttgtgtgt gtggatactg tattagttaagacaaaaaaa
7801 tctggcttca tatgttataa aataatgtct ggagctatcc actcaagtgtgctttcttgt
7861 ttctctgttt tttttttttt cctatttcat tcagtggttt tcactgcctttgggaaaaag
7921 tgacacagca aaacacttag aagaatcaaa tgtttatcct ttgagaatgtggtctgtaca
7981 taagagaaaa catttagaat caaattatga gactaaacca gtttccctcacctgcagcta
8041 gataaaaatt tctaagagga aggagagaat caggaaagat tgaagacttgactccctgat
8101 aagggttctg cccgagttct gagaatggag aataaaagac accctccccctctctaatag
8161 attttgtcag tgaaggtcag agaggcccac gaaatcaggt ctggggagcaaggtaaaacc
8221 cagaatttct acatgatcat gttaaagagg gaataaagga atatcattatagtgtatctg
8281 ggcaggtggg catgagacag cctgattgag ttcctgaaat cccaggtcggtgtgggagca
8341 gcagaatatt ttaggtggct gagagctcca tagtttcttt ctttctttctttctttgaga
8401 tggagtctca ctctgttgcc caggctggag tgtagtgacg cgatctctactcactgcaac
8461 ctgtctccct ggttcaagta attatgtctc agcttcctga gtagctgggattacagatgt
8521 gtgccaccac acctggctaa ttttttttta tttttagtag agatgggattttatcatgtt
8581 gcccaggctg gtctcaaact cctgacctca agtgatccac ctgcctcagcctcacaaagt
8641 gctgggatta caggtgtgag ccaccagcag tcccagctac tcaggaggctgaggcagaag
8701 aatcgcttga acccgggagg tggaggttgc agtggaccga gattgtgccactgcactcca
8761 gcctggtgac agagcaagac tccatcttaa aaaaaaaaaa accttctcaaggtattttct
8821 gtgcttcttg ttttctcttt tgtatttttc atctttatat ctttgtgtttcattctggat
8881 aacttttagt gacctgtctc ctagttcact aattctcttt ttagctatgtctagtattat
8941 aatttgttta ttgaattatt aagtttaggt atcaaatttt cagctttaggatatctaatt
9001 tgccacttgt tttctgccat gatttttttt ttttttttga ggtggagtcttactctgtca
9061 cccaggctgg agtgcactgg tgtgatcttg actcactgca agatctgcatcccgagttca
9121 catcattctc ctgcctcagc ctctcaagta gctgggacta caggcgcctgccaccacgcc
9181 cagctaatta ttattattat tattattatt tgtattttta gtagagacagggtttcacca
9241 tgttagccag gatggtctcc atctcctgac cccatgatcc acccaccttggccttccaaa
9301 gtgctgggat tactggcatg agccactgca cctggcttct gccataatttttaaccttga
9361 gttttaccta cttaaacata gcaaacacag ttgtttatat atttatctaataattccagt
9421 atcaggagcc tctggagtct acttttgtct actttcattg ttttttgttttttaaattta
9481 cattaacagt gtctagtctg tatttatgcc tggttacttt tgattgtgtgctagacattg
9541 tttttggcaa ataatttttt aaacacaata tgtacaaatc atatgaagcctagactggtg
9601 ttttgttcac caaaaaagat tttaaattac ttcagttacg ttcctagggacactattaac
9661 tcaggatgat gttaattgaa gtttcagatt tgatattttc caggtcaactggaccaactg
9721 tccctgctat atgatttatt tcctaaagca atatcaagtt cagctctgcacctctcttat
9781 atactatgga gctctcagtc acataaaata ttctgctgct ctcacactgccctgtagttc
9841 ataagaggaa cagtttactg ttaatccgta ttactcttac atctagggtgtagctctttg
9901 agctaccagt ccaaagtgaa gaataattta ctgaattcct actttgtctggctctaggca
9961 ctgatttttt ttaccctctt ggccacctat cttcaattgg aaaatgccctcaattcaaaa
10021 atgctccaag tgccaagctt tcctatctga attcccattt tttcctgtatctggctggca
10081 attcattaga atcctgctag ccctctgatg cttctaagat tttcatcttttatttttatt
10141 tatttattcg agatggagtc ttgctctgct gcccaggctg gagtgcagtggtgtgatctt
10201 ggctcactgc aacctccatc tcctagggtt aagtgattct cctgcctcagcctcccaagc
10261 agctgggact acaggcatcc accagcatgc ccggctaatt ttgtatttttagtagagatg
10321 gagtttcacc atgttggcca ggctgatctt gaactcctaa cctcaggttatctgcctgcc
10381 ttggccttcc aaagtgttgg gtttataggc attagccacc atacccagcctgaagttttg
10441 attaaaaatg ctttactggg ctgggcatgg cagctcacgc ctgtaatcccagcactttgg
10501 gaggttgagg cgggcagatc acttgaggtc aggagttcga gaccagcctgaccaacatgg
10561 tgaaacccca tctctactaa aaatacaaaa attagccagg tatggtggtgcatgcctgca
10621 atcccagcta ctcaggaggc tgaggcagga gaatcgcttg aatctgggaggcagaggttg
10681 cagtgagccg agatcgtgcc actgtactcc agcctggaca acaagagcgagactccgtct
10741 caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaactttaccggaatt
10801 aaagcccagt catcttgaag ccatgatcat gacgctgtgg aagaaccggtgaggtaggat
10861 gagacatatt ctcagatgct atgctgattt ggggctgtga tgattttggaccatagacta
10921 tgatgaggct tcaaaaagag tgcaatagtg tattttaatt tctttggttagattcaaatt
10981 aatcttcaga aagacaaaat gcagatgtag tcttgttaga gcttgctgatgagactaaat
11041 tttccaagtg tttgaggaat gcctaacagg ggaaaggcaa agcaaactatttttaatgac
11101 cttatggctc tgaattgcta aaagggagtc agtccaccag gctcaggctacttggagtag
11161 aggatcctgt ttcagtgaca aactggctca tcccttaatc tgccataaaatgatggctta
11221 gcatacatgt aggagctggg gctaagggag aaggaggtgc tgtgttttgcagaagaagct
11281 acattctgta gtaaggcctg actcttccct ggccttggag gggaaatacttgtgagacag
11341 tggccaggat cagctgaagt gccctctctt cttgctttgc ctatgggacactgagcccct
11401 ttttgtggaa tatattcatc cagagaaccc tcacacctta taatgcataaagtgataaag
11461 gcttggagat ctggagaaac ccaaggtgcg atccctggct ctagaagaaactctgggcag
11521 ccagcatgat ttacttttct ctgctccaaa gactggagga taaattaaaggaaaagaggg
11581 tatgacccag caatccactg gtgcgagttg ttgctttaag caaagactactgcttctctt
11641 cctgattttc ccctgaccat actctcccag aggtgtctcc cagcaaccaccagagttgtg
11701 gttaagtaca cctagccaat ccaataaatc taaaggagat gcagtccacacaaccttgca
11761 tgacttgtca tgtgagttac tgttctggag agacaaactc aggctggaaacttatttgag
11821 atagcttatg aaaacaaaga taatttatga taaggataca ggcactctcatacaatctaa
11881 ggtagaaaaa cagctaagca tcagaacaaa ctggaccaaa gacttaaacacttctgctcc
11941 tttgtgtaat tggtttcatg cgtttctctc tctcccttcc tctctctcttttctctctgt
12001 ggactaggtt tttctacttt tcatatacaa attttaaaaa tacaatttctggccaggtgc
12061 agtgactcac gcttgtaatc ccagcacttt gggaggccga gggaggtggatcacttgagg
12121 ccaggacttt aagaccagcc tggccatcat ggtgaaactc catctctattgcaaatacaa
12181 aaattagccg ggtgtgatgg tgcacgcctg taatctcagc tacttgggaggctgaggcag
12241 gagaatcgct taaacctggg aggcagaggt tgcagtgagc tgagattgtgtcactgcact
12301 ccagcctggg taacagagtg agaatctgtc tcgaaataaa tgaataaataagtaaaataa
12361 acaataaaaa taaataaaga caattttaaa aatttcccaa cattaagtgtcagcaatttg
12421 gagagggaca gctgtctctt gttctctctc ttctccaatt ctcaattcctaggtctgatg
12481 ctttccctgg ctcaactgac tatggttgtg gggtagggcc atgaaacagaaatatcacat
12541 taggatccaa cctttaatta tgtagatgga cagcagttta cagaaaaagtggtggggagg
12601 tggagggagg tgctgaacag acattctaaa agggctccac caaagaaagctatttgttat
12661 atttatgaac attctggaaa attctttcaa ttgtgttcat gaataaattatgattggtta
12721 aaagctaaca cacatgtaga ttatataact tctaaaattt gtatttggtatctgaatcta
12781 tatattattt tggcatgtat agaaaaatcc cagatatttc aaaggctatcattagaaaaa
12841 cgttaatgaa aaggttaatg gaattctata tatttagttc ctgtgagaatgtccagttta
12901 actttcttaa tcaactgatg aagaaacaga actgaaatca caagattataaagatatttt
12961 aacgatgcat ttaggttttc attctaaatg ctgaaaaaag gtatccctgcaaatactggt
13021 taagaaatta agaagtccaa aacccaataa tgtagttggc agcctgttataaagatttag
13081 agtattcaaa gataaaggca aataaaaaga ctacttttta taccagagtagaaacagttt
13141 attttcatga tcactactct tacttcaaat atatctatta tctaagttgatgcttgcaaa
13201 aagtcctgat tcttacacaa aggcagtcga ttcatggatc tcttagagagagagaaaaaa
13261 aaaaagctag ttgggtgtgt tacagttata tgaatcatgt aggatgctgcttaacgctat
13321 atttatcatg gatgaaggca tgttttcagg ggaaactatg agtctacctaaagttaccca
13381 gttcacctct gttccaaggg actcatcttt tcagcatttt gtttagcatgttacaaagta
13441 ccccgatgtc ttctaaacta ttaggattgc aggaggaaac tctcccagagctgctagaag
13501 tcatccttga aagtttggat ttctcccgaa aacttgtatt tctatcattgttttaactat
13561 cttcttgaat cctcttgatc ctgacctaca tgtcctcttc ccttgattgcatttaaattt
13621 agctgcatat aaccttgctc ttttccttct aatccaacct ataaaccatatcaggggagg
13681 atatgtgatt tgtcaatttt gttgcctcac ttcctcctca agaactttcagtggctccat
13741 tttacctctg agattaaatt gcagccactc atcctgagtt ttggtgttccacaatctgac
13801 atatctagtc agctttgtgt tctagtgtgt ttgtgttgct ataaaggaagactgagacta
13861 gatagtttaa taagaaaaga ggttgatttg gctcacaatt ctgcttgctggaagattggg
13921 catttggtaa aagccttagg ctgcttctat tcatggcaga agagtaagcggagccttcat
13981 gtgtggaaat catagggcaa gggaggcagc aagggaggtg tggagaggtgccaggctctt
14041 tttaacaacc acttctcatg ggaactaata cagtgagaac tcactgactctttctacagg
14101 gagggcatta atttattcgt gaatgattct cccccatgac caaaatacctctcattaggc
14161 cccacctcca acattgggat aaaatttcaa catgaggttt gaaggggggacaaacatcca
14221 aactatagca ttctgctttg gccccctaaa acttatgtcc ttctcacattcaaatacaat
14281 catttcttcc taatagtccc taaaagtctt aacttgttcc agcataaactcaaaagtcca
14341 aagtccaaag tatcacctgc gactcaaggc aacttcttta cagctgtgagcttgcaaaaa
14401 taaaaaatga attatattct tccatgatac aatggttgta caggcattgagtaaacattc
14461 ccatttccct aagggagaaa ctggccaaaa gaaagtggta acaggtcccatccaagtctg
14521 aaacccagtg cggcagacat tctttttttt gaggcagagt ctcgctccgtcacccaggct
14581 ggagtgcagt ggtgcgatct cggctcactg caagctctgc ctcctgggatcacgccattc
14641 tcctgcctca gcctcctgag tagctgggac tacaggcagc tgccaccatgcctggctaat
14701 tttttgtatt tttagtagag acggggtttc actgtgttag ccaggatggtcttgatctcc
14761 tgacctcgtg atccgcctgc ctcagcctcc caaagtgctg ggattacagacgtgagccac
14821 cgcgcctggc cagacattaa ttcttaaaac tccaaaataa tttcctttgattccatatac
14881 cacatcctgg gcatagtagt gtgaggggtg ggtcctaagg ccttaggcagccccactctt
14941 tggctttgct gggtgcagcc cacgtgactg ctctcacaga ttgaagcccaatgcctgtgc
15001 ctttttcagg ctgcagttgt atgttgctgg tggctctata attctggggtctggagggtg
15061 gtagccctgc tcccacacct ccaatagata atgcccaagt agaggctgtgtgtggttgat
15121 ctgaccctat ggcagacttc tgcctgcctt cccaggtgtt ccaataaatcctctgaaatc
15181 taggtggaag ctgccaagcc tccaacattc ttgcattatg ggcacctgcagatttcacac
15241 catgaagcca ccaaggctta ccacttacac ccacctaagc agtggctcaaacagtacctg
15301 gggccattgg agccatggat ggagccagag tggccaggat gcagacagcagcatcctgag
15361 gcagcacagg gcagtggtac cccaggcttg tcctgcaaaa ttattttgtcctcctaggcc
15421 tctaggcttg tgatgggagg agcagcctca aaggtttctg aaatgcctttggggcctttt
15481 ttttccaaag tcttggctat tagaacctag ctcccactta gtcatgctaatatctctcta
15541 gcaagtgttt ggctgcatcc ttgaattcct ctcctgaaaa cactctttcttcatctacca
15601 cagggccagg ctgtaaatct tccaaatttt tatgctttac ttggtttttagttacaattt
15661 acaactttag gtcactcatt tgctgccata tctagtttac aatcatatttacaattaaaa
15721 gcagtgtaaa ccaaaaagta tctgagacag gtctcaatca atgtaagggtttattttgcg
15781 atggttaagg accatggccc atgacacagc ctcaggaagt cctgagaacatgtgcccaag
15841 gtagttttgt gtagcttggt tttatacatt ttagggagac agaagttacagacaaaaaca
15901 taaatcaata catgcaaggt atacattggt ttggcccaga aaggcaagacatctacaagt
15961 gggggcttcc aggtcatagg tatattcaaa aatttcctga ttggcaatggttgaatgagt
16021 taagctctgc ctgaacagtt gaagtcagct tgagttaaga taaagaggttggctgggcac
16081 tgtggctcat gcctgtaatc ctagcacttt taggaggctg aggtggtcagattgccacct
16141 gggcaatctg tttgagatca gcctgggcaa catgatgaga ccctgtctttccaaaaaata
16201 aaaaaattag atgggcatgg tggagcacac ctgtagtcct tgctactcgagagactgggg
16261 caggaggatt acttgagccc aggaggcaga ggttgcagtg agctgagattgcaccattgc
16321 attccagcct gggtgacaga gccagaccct gtctgaaaaa aaaaaaaaaaaaagtgaaag
16381 tcaaggttct tgtcatgtgg atgaagcctc caggtagcag gcttcagagtgaatagatga
16441 tgaatgtctc ttattagaac ttaaaaggtg tcagactctc tggaaaaaacttggtaaggg
16501 agagattctc tacagaacac taacttcctc cacaagagac aacattgcagggccttttca
16561 aaatgtcaaa taaatatatt ttgggataaa atacttgtat tgtattgtattgtattgtat
16621 tgtattgtat tgtattgtat tgtatcgtat ttttgagaca gagccttgctctgtcatcca
16681 ggctggagtg cagtggcacg atctcggctc actgtaacct ccgtctccccagctcaagcg
16741 attctcctgc atcagcctcc tatgtagctg ggattacagg tgtccaccaccatgcctggc
16801 taattttttt gtatttttag tagagatggg gtttcaccat gttggccaggctggtcttga
16861 actcttgacc tcaagtgatc tgcctgcctt ggcctcccaa agtgctgggattactgggat
16921 tacaggcatg agccaccaca cctggacaat aaaatacttt tatttcctttaggtcttgct
16981 atgtcatgtg atgctatatc agagtcgggt tcaaatttgg tatcttattgctacaaagag
17041 tctgtcttgt cagtcatatg atctctgttt taatgttaat gctggtcatttgtgtctaaa
17101 ctccaaaggg ggagggtgta ataaggcatg ttgggtaccc tctcatcttgctatggcatg
17161 agctagtttt tcaggtttct ttgggatctc cttgaccaag gggtccattcagttgattgg
17221 gggagtttga attttaattt tgatttccag cagccacgcc acttcttgaatgctgtgttg
17281 cttagaaatt tcttctgctg ctgggcatgg tgactcatgc ctgtgagaggcaggcacttt
17341 ggaaggctga ggtgggcaga tcaattgggc tcaggagttt gagaccagcctgggcaacat
17401 ggcaaaaccc catctctaca aaaaatacaa aaaaaaaaca acaacaaaaaaacaaatcag
17461 ccaggtgtgg tggcatgtgc ttgtagtccc agttactcgg gaggctgaggtgggagaatg
17521 acctcagcct aggagatgga ggtttcaatg atcctagatc gtgccactgcattccagcct
17581 gagtgacaga gcaagatcct gtctcaaaaa caaaacaaaa caaaacaaaatttccgccag
17641 atatcctagg tcatcactct taactgcagc cttccacaaa tccatagggcatggacacaa
17701 cacagccaag tttttttttc taaagcataa catggaaccc tttgctctagttcccagtaa
17761 gtttctcatt tccttctgag acctgctcag ccttgccttt actatctatatttctatcag
17821 cattttggtc aaaaccactt aactaatctc taagaagttc caaactttccctcatctgcc
17881 tgtcttcttc tgagccctcc aggttcttcc aacctctgtc caatgccctgttccaaagtt
17941 gcttccacat tttcagttgt ctttacagca acatttcact acttggtaccagtattctga
18001 ctttgtccat tttgcattgc tttaaacgaa taccggagga tgggtcatttacaaagaaag
18061 gggtttattt ggctcacagt tctgcaagcc tgtacaagaa gcatggtgccaggatttgct
18121 tttggtgaag gcaaggaagc ttccattcat ggcagaaagt gaaggggagcctccatgtgc
18181 agagatcaca tggcgagaga ggaagagcgt gagaggaggg gaaggtaccatggtcttttt
18241 aacagaggta caggcttttg agggaactaa cagattgaga actcgctcactcccacccct
18301 gccagggagg tcattaatct attcatgagg gatccaccca cataacacacacatctcact
18361 aggccccacc tccaacattg ggatcaaatt tcaacatgaa gtttgggagggcgaacatcc
18421 aaagtacagc accttgtttc ttgttgtttt ctaatatttg ttctttatcccaggaaatgg
18481 ggggtaggaa ggtgagttct tggtgtactc taagcagtca tgctcagcctgtactatcaa
18541 attttattcc atttattctt ctgttgaggc ttgcatgact tccctaaggtacaatggcag
18601 agatagccac atgggtagta aaatcagggg cagacagacc agctttctgccaggaattta
18661 cctcagggaa attcctcatc tttgactttc ctcgttctga cttttttttcttttaattcc
18721 acctcctctc caaacctggc actattcctt tccgatcttt atccttgtccttactgtttt
18781 gaagttggct cttatgcctg tttgtctttg caatctgtct ctgcgtcgcgtgttggtagt
18841 catttatttt tgtccctagt catgattccc agaaccttgc tgtggtcattttgatgcccc
18901 accctttgac tattacaaac caggagagct catgcaagtg gccacatgctgtagtggtta
18961 agagcacagg ccccgtagct gaacttgaaa ctcagcatga caacatgctggctgtgtgac
19021 taaggcaaat taaatgacca ctctgtgtcc ttattttctt atacataaaatggagctaca
19081 atagtacctc ctcataggga tgttgtgaag cttcagtgag ttaatacagatataatgatt
19141 agttatctgc ctccattaaa tccaatcatc aatactaccc agctttattaaaacttctga
19201 cttttgtttt ggatgtggcc aggtcctgaa ctgaattgtt ttttccaggtcaaatttaaa
19261 tctaccctcc tttccttttt ctcaatgcca aattgttctt cagtttccatctctagcccc
19321 ataatctttg atttctcttg cccacatgga tggttacctt ttctgaaatgtcatagctct
19381 tacagtgcta gccacctatt ttgatgccaa atctttacac caaccagtgttatcacttaa
19441 tcaattctta catctatgtc ttaacttctc caaccaaact taagacttgttggtgccaag
19501 aatcaaatct catacttttg agttattcaa accatacaga acagtagatactgaataagt
19561 atttgtctga atgaattgtt tgaataactt aaagagccta gaagcggctgggtgcgatgg
19621 ctcatgccta taatccgagc actttgggag gctgaggcgg gccgatcacctgaggtcagg
19681 agttcgagac cagcctgaca aatatgatga aaccccgtct gtactaaaaatacaaaaatt
19741 agccgggcat ggtggcatgc acctgtaatc ccagctactc aggaggctgagacaggagaa
19801 tctcttgaac ccaggaggtg gaggttgcag tgagccaaga tcacaccattgcactccagc
19861 ctgggcaata aaagcaaaac tccatctcaa aaaaaaaaaa agagcctagaagctttccag
19921 ggtggtcttg ggggtattgg ctttagaaga ggaagcttga tagatgaaaatttccagatc
19981 aacggcattt tatgtacttc tcagaaacaa ggtatgacta gactgaaagatctgaagtca
20041 ggaagaaact tcttggtatc agtctgtgcc cttaggaaga agtgaggtcataagctctat
20101 tagcacacat agctgaaaaa ctgaaagagg atgtaagaga aaggattgttaaaaaacaaa
20161 aacaaaaaaa cacaaaaaac caaaaataaa aaatctgggt gaggtatttgcaatactaga
20221 gccaaagaat ttgacctaag aggccgggcg tggtggttca catctgtaatcccagtactt
20281 tgggaggccg aggtgggtgg atcacttgag gccagaagtt tgaaactaacctggccaact
20341 tgttgaaacc ccatgtctac taaatacaca caaaaaaggg cccggcgcggtggctcgtgc
20401 ctgtaattcc agtactttgg gaggctgagg tgggaggatc acctgaggtcaggagatgga
20461 gaccatcctg gctaacatgg tgaaaccccg tctctgctaa aaatacacaaattagccggg
20521 tgtggtggca tgtgcctgaa gtcccagcta cttggagggt gaggcaggagaatcacttca
20581 acctaggagg tggaggttgc agtgagctga ggtagcgcca ctgcactccagcctgggcga
20641 cagagcaaga ctctgtctca aaataaacaa ttaactgggt gtggtggcacacacctgtaa
20701 tctcagctgc tcctgagcct gaggtgggag aatcacttga acccgggaggcagaggttgc
20761 agtgagctga cattgtgcca ctgcgctcca gcctaggggg gagaaaaagaaaaaaaagaa
20821 ttctgatcca ggcactgact cattgagcaa gtcatcttta ctgttcaggcctcagctttc
20881 ttcctttgtt tttttttgag acagagtctc attctattgc ccaggctggagtgcaatggc
20941 atgatttcag ctcactgcaa cctctgccgc ccgggttcaa gcaattcttctgcctcagcc
21001 tcccgagtag gtgggattac aggtgcctgc caccgcgccc agctaatttttgtactttta
21061 gtagagatgg gggtttcact atcttggcca ggctggtctc gaactcctgacctcatgatc
21121 cacccacctt ggcctcccaa agtgctggga ttacagatat gagccaccgcacccagctag
21181 gcctcagttt tctaatgtgt aaaatgaaaa tatgcactag accttcacttgtttttttct
21241 atgtgataat tttttttaaa aaaagaaggt gtcatgttac attttatctttatgtttaca
21301 tttcatcttg taaggttgcc tttgagcctt gacacagtga tttttctcattcaactagtt
21361 tctctcccat ctcaactagt gacctcacca tccactaatt gtttaagccagaaattggga
21421 acttttcctt ggttcctctt ccttgtttac ttcttccatc taccccatgagcaaatccta
21481 tctgttcttc cttaaattta gttcccagat ctatctcctg catctcaggtctatgtactt
21541 cttcccatct cccctgctac tagtctgtcc agagctacaa ccacttcccttatagattat
21601 tggaataacc ttcttattgg tcttcatatt ttcactctga ctcccctctgatcaattttc
21661 tgcaatgcag ccagaattat cttttaaaaa tgtaagtttg agccaggcacagtggctcac
21721 gcctgtaatc ccagcacttt gggaggccaa ggtgggagga tcacctgaggtcaggagttt
21781 gagatcagcc tggccaacat ggtgaaactc tgtctctact aaaaatacaaaaattagctg
21841 ggcatggtgg tgggtgcctg taatcccagc tacttgggag gctgaggcagaactgcttga
21901 acctgggagg ccatatatat ataaagtttg atcacaccac tgtcctgcttaatctttttt
21961 tattttttaa cttttaaatt ttttaagaga agggtctctc tgtgttgcccagactggtct
22021 ctaattcgtg ggctcaagag atcctctcat cttagcctcc caagtagctgggaatacagg
22081 catgtgccac cacacccagt gactttcctt cctaaaatgc ttcaatagtttctttttctt
22141 tttctttctt tctttttttt tttttttttg agatggagtc tcgttctttcacccaggctg
22201 gagtgcagtg gcgtgatctt ggctcactgc aacctctgcc tcccgggttaaagtgattct
22261 tctgcctcag tcttccaagt agctgggact acagcatgtg ccaccacacctcaataattt
22321 tttgtatttt tagtagaaat gggtttcacc atgttggtca ggctggtctcgaacagctga
22381 gcttgtgatc cacccgcctc ggcctcccaa agtgctggga ttacaggtgtgagccactgc
22441 acccagccac ttcaatagtt tctttttgtg cttaacataa agtttaaattcatgtccaga
22501 gcctataagg tgtcatatga ccaggcccct caaggtatat ccacttcactcaagccatgt
22561 ttgtctcatc ttaattcttc aaacacccca cattctttcc taactcaaggtctttgagct
22621 tgctgcttct tccaggtgga ctgatcttag cccttccctt tgttgttgattttttaactt
22681 tttttttttt ttttttgtga gaaagtcttg ctcttgtttt ccaggctggagtgcagtggt
22741 gcaatctcgg ctcactgcaa cctccacctc ctgggttcaa gtgagtctcctgactcagcg
22801 tcctgagtaa ctgggattac aggcacctgc caccacaccc ggctaatttttgtattttta
22861 gtagaaatgg ggttttgccg tgttggccag gctgatcttg aactcctgacctcaggtgat
22921 cctcccacct cggcctccca aagtgctggg attacaggca tgagccagcgctcccagcct
22981 ttttaccttt ttttttttta atttcaatag gtttttgggg aacaggtagtttttggttac
23041 gtgaaaagtt ctttagttgt gatttctgag attttagcac acccatcacctgagcagcgt
23101 acactctacc caatgtgtag ctttttatcc ttcacccccc caagtctttccctgagttcc
23161 caaagttcat tgtatcattc ttatgccttt gcattctcgt agcttagctcccacttacga
23221 gtgagaacat acaatatttg gttttccatt cctgagtctc caattccacccaggttgctg
23281 tgaatgccat taatatgttc ctttttatgg ctgagtagta tttcatgatatatatataca
23341 cacacacaca cacacacaca catatataca cacacacatt tatatgtgtatatatacaca
23401 tatatatata tgtcacattt ctttatccac tcattgattg atgggcatttgtagccctgc
23461 cctttgaatg gctgacttct tcttatgctt cagaattaat actttgtaattacattaata
23521 tgtttttttt aaaaaaaaac cttttacata tatattggtc tgtcacaataatgtataaca
23581 atattatagt ttctgtttta atgacttaac tttggcaaac tggtcaatgatttcattaaa
23641 actgatcttt ttaaaaataa tcagcttcaa tagacagttt aaccagatttgtcaactttt
23701 tgtttttggc acagtctcac tctgttgccc aggatggagt gcagtggtgccatcttggct
23761 cactgcaacc tctgcctcct gggttcaagt gattctcatg cctcagcctcccgagtagct
23821 gggattagag gcacctgcca ccatgcccag ctaagttttg aatttttagtagagataggg
23881 tttcaccatg ttcgccaggc tggtctcgaa tgcctgacct caagtgatctggctccctcg
23941 aactcccaga gtgctgggat tacaggcgtg agccaccaca cccggtctccataaaaaaat
24001 cttaaacaaa aggatatggt tggtgaaata caaatcctat tgcgcagtaattttcacaaa
24061 ttttaaaatt gacaatacct tcgcttcttt cagatcaatt atagtggctttcaaatgtca
24121 tcgctcaaaa aagttcaaat gtcatcgctc aaaaaaaaaa caaaccttcactagaaaatt
24181 aatcataaat tgatggtaca gactgggtgc agtggctcac aactgtaatcccaccacttt
24241 gggaggccga ggtggatgga tcacctgagg tcaggagttc aagaccagcatggccaacat
24301 ggtgacaccc cagctctact aaaaaaaaaa aaaaatgaaa aaattagcccggcgtggtgg
24361 tgcatgtctg taatcccagc tacttgagag gctgagacag gagaatcgcttgaatgcaga
24421 aggcggaggt tgcagtgagt cgagatcata acactgtaat ccagcctgggcaacagaggg
24481 agactcctca aaaaatataa aaataaataa attgatgtta catttggaaaaactgctgaa
24541 attttcttct tctgcaaaaa gttagaaaaa accactgaat gattgaaaacattgacatta
24601 tttaattctt tgctttagag caagtactca gttcttgatt gaagtgattgagggattcaa
24661 acattgtcct tttgttttct tccggtaacg tcagaccagc atattttgttattgctgctg
24721 gctgttttct tcaaaatttg ctttgaaaaa gatgtaaatg gccatttccttatacttgtg
24781 attaaatatt tgttggcctt tccaccagtt ctctgcactg atcttcaagaaaaaatttta
24841 aaacctgcac acaaaatttt aaagactgaa cacagaattt taaagcatgcacatttttca
24901 aagctgtttc tatctctttg gaagtttgtg tctgattaag ttcatctaagacttcactcc
24961 aggaaaaaag ttaacccaga aaagataaat agcctcagca gagagaaaaatctactgatt
25021 ttcttgtgtc tacattttgt tttagatagc ataatacttc aaaagttggtactcatttct
25081 taaactttac tgtgtgcata gcttcaaaat gaatactttg ttgtgtgtgggaaagccttt
25141 tcattgttat acttacaatc ttcagcatgg tccatccgtg aatcttttttaaaattgata
25201 aaaaggccag gcgcgatggc tcatgcccgt aatcccagca ccttgggaggccaaggcaag
25261 tggatcacct gaggtcagga gtttgagacc agcctggcca acatggtgaaacctcgtctc
25321 tactgaaaat acaaaaatca gctgggtgcg ttggcgtgcg cctgtaatcccagctactca
25381 ggaggatgag gcaggagagt ggtttaaacc tgggaggcgg aggttgcagtgagccgagat
25441 tgtgtcactg cactccagcc tgggcaacag agcgagactc cttctcaaaaaaaaaaaaaa
25501 aaatggttaa aaagatgaaa taaaaatttt ccaagttccc ctcaacccccctaaaaaaaa
25561 atcatacatg aagaaacatt tccaaaacag tggagtttgg agattgatttgcacaagcac
25621 aaatgaggat ttaggataaa tttctttgac ttttacctga acactacagtcagtcttggc
25681 catagtttca gcattgccat gtccttggtc atgatagagg ttcatgtccagcatatcaca
25741 attcagtcat atggtgacta ttatgtgagt tcaggagtgt ttatcctagaaatagaaaga
25801 cacccaggaa tgactccttt ctttcaaatt tgctgttctc aaaatgaacatacttaagga
25861 ctttacattt gatcagggta taaaccactg ggaagactaa gtgctcagaaaaagaaccaa
25921 agacttggag ataggaacag agcctgaaat gaacagaaac tattctataccccccatgaa
25981 cctagaaaca aatgtgtata gctaagcgta ttagtccact cgggatgctttaacagaata
26041 tcaataaact ggaatgcttc acagtaaaca tttatttctc acagttctggaggctgggaa
26101 gtccaagatc tggtatctgc tgaggttcct cttactggtt tgcagatggccgtcttcttg
26161 ttctatcctc acatggcaga gagcagagaa cagaccatct cttgtgtctgttcttagaag
26221 aacattaatc ctatttatga gcactctacc ttcgcaacca aaaggcttcatctccaaata
26281 ccatcacttg gagatttagc cttcaacaca ggaattttgg gggtacacaaacattcaatc
26341 catagcactg agtctgtatg tgttgggaac tgattgataa attggaattcttcaaattaa
26401 cttacatgta gaatacagta tttattaaag gataagtaaa aagaaatgtgttaatttata
26461 gtgtatttat tattattaaa agtctatagg gctgggcaca gtggctcatgcctgtaatcc
26521 cagcactttg ggaggccaag gtggggtgga tcacgaggcc aggagtttcaagatcagcct
26581 ggccaagatg gtaaaattcc atctctacta aaaatacaaa aattaattgggcatggtcag
26641 gcgcacgcct gtaatcccag ctacttggga ggctgaggca ggagaactgcttcaatgaac
26701 ccgggaggtt cattcaagat cacgccactg cacttcagcc tgggtgacagagtgagactc
26761 tgtcttaaaa aaaaaaaaaa aaaagtctac agtaactgca attgtttagaatttaagcca
26821 acaagatatg ttttcttttc cgggagttgt attttttatc actgattgtctacaattgac
26881 agtgcatgtc aaaaagcaga cttgtcgtgc tgcagtggct cacgcctgtaatcccagaac
26941 tttgagaggg cgaggcagga ggattgcttg agcccaggag ttggagaccaacctgggcaa
27001 catagtgaga tcccatctct aaaaaaataa aaataaaacc actcatttttgtcaatttta
27061 ttactgcttt taatttttct aaagacgatg tgctgctcca gctctgggtacacacatgcc
27121 cacgagagca agctcatgag agaagaaact acatcccctc tatccacctatatttctaac
27181 gccttgcaca gtagctggca catagtggac atgaaataaa tatttgtggaataaataagt
27241 gaagaagaat tttagaatac tttataagaa acaataaatc ttcagagatcaacatttcaa
27301 attagtaact ttatttacaa acctctcttc tgggttttat tatttactacaagtgcttgc
27361 aagacctgtt attgtacact catgtattcc tatcaaaggt aatcatcagacattatattt
27421 cattaaataa tttaatggtg ctttctgttc tttattcatt aatttttttgtgtgtgtgtg
27481 agaatggagt ttcactatgt tgcccaggct ggccttgaac tccagggttcaagtggatcc
27541 tcctgccttg gcctcccaaa gtgctgggat tacaggcatg aaccaccatgtccaacaatg
27601 ttttctgctc tttagtaagt ctagccatat taaattttat gtgttttttttttctttttt
27661 gagactgagt ctcactctgt cacccaggct ggagtgcatt ggcgcgatctccactcagtg
27721 caacctccgc ctcccagttt caagcaattc tcttacttca gcctcctgagtagctaggat
27781 tacaggcacg taccaccaca tctggctatt tttttttttt ttttttttgagacgaagtct
27841 cactctgttg cccgagctgg attgcagtgg catgatcttg gctcactgcaacctccacct
27901 cctgggttca agtgattctc ctgcctcagc ctcctgagta gctgggactacaggcatgtg
27961 ccaccatgcc cggctgattt ttgtatattt tttaacagag atggggtttcattatgttgg
28021 ccaggttggt ctcgaactcc tgacctcgtg atccacccac cttggcctcccgaagtgctg
28081 ggattacaga tgtgagccac cgagcccggc ctaatttttg tgtttttggtggagatgggg
28141 ttttaccatg ttggccaggc tggtctcgag ctccggacct caggccatccacctacctcg
28201 gcttcccaaa gtgctaggat tacaggcgtg agccactgtg cccagctcatattacatttt
28261 aaatggaggt agaatatcaa cctgaattca ctaagagaat gcaggacaaattgccctgat
28321 atcctgacac aaaggtgaag caggactttt ttgtaatttg aggatttaaaagcatggttg
28381 ctccaggcca ggcgtggtgg ctcctgcctg taatcccagc actttgggaagccgaggcag
28441 gcggatcatt tgaggtcagg agttggagac cagcctggcc aaaatggtgaaaccctgtct
28501 ctactaaaaa tacaaaaatt agctgggcgt ggtcaggcgc ctgtaatcccagctacttgg
28561 gaggctgagg caggagaatt gcttcaagga acccaggaag cagaggttgcagagcccata
28621 tcgtgccact gcactctagc ctaggtgaca gagcgagacc agcctggccaacatggtaaa
28681 accccgtttc tactaaaaat acaaaaaatt agcagggcaa gctggcgggcgcctgtaatc
28741 ccagctacac gggaggctga ggcaggagaa tggcgtgaac ccaggaggcggagcttgcag
28801 tgagctgaga tggcgccact gcactccagc ctgggcgaca gagggagactccatctcaaa
28861 aaaaaaaaaa aaaaaaaaag tatggttgtt ccagtcctgg gaaattgaaatagggggtaa
28921 aaaggctggt gggtgtggta ggcagaataa ttacttcttc cctctcccaagatgttcagg
28981 tcctattccc catcctattc cctggaacct atagctagat tgccttatggggcaaaagga
29041 atttttcaag tgtgactaaa tttagaatca tgagttagag agattatcctggattatctg
29101 tgtgggttta atgtaatcac aggggtccct agaaagaaaa gagggaagcagaaaagccaa
29161 aggagatgga atgatgggag ttgagatcag tcagatttac agatgcaatattgtttccta
29221 taaattctgt ggtgaaagaa atgctatatt gttgctggct ttgaagatggaggaaggggc
29281 tgagagtgaa ggaatgcaag tgaccttaaa ttggaaaaga caagaaaataattggccctg
29341 tagaggttat aaaagaaggg tggtccttct gacacactga ttttagtccgatgagattga
29401 ttttgaactt ctgacttcca aaaactgtaa gacaatacat tagtgttattgtaaaccact
29461 acatttttgg taatttgtta cagcaatagg aaacttatat agtgggccctgggatccatc
29521 tgccctagcc gtttatctaa aacaaaagat cttataggga aagcaaacaaacaaacaaaa
29581 aatacagaaa caaagcaaaa caaagcaccc ctatgctctg agcttgggcctggtaagggc
29641 actatgagcc catgatttag catgttgctg ggaaatctcc ttccccctgttgagttgcca
29701 gaatcgtgga agcagatggt gtgggggatt caggctcctc cactgcttttctcagccaga
29761 cctttgagga gagcttggct gaagtcttcc aagctttatc cccttgtagccattgttttg
29821 agccatctca aacattaagt agctcttgag ggttgaattg agtccttcctaaagacagac
29881 taaagtccta gtctccagga cctgtaaatg ttcccttatt tgtaattaggatgtttacag
29941 atgtaatcaa attaaaatga ggtcataccg gactagggtg ggctctgatccaatatggcc
30001 ggcatcctca taagaagagg agaagagaca tagacacata gggaaaagaccgtgtgatga
30061 tggcagagat tagagtgatg tgtttacaag ccaaggaatg tcaaatattgccggcaatat
30121 cagaaactaa gaaaaaggca tggcacagat tgtctctgag agcctctcagagagtatggc
30181 cctgctgaca ccttagtttc agaggtctag catccagaac tctgagagaacagatttgtg
30241 ttgttttaag acacccacca tgtggtaatt tattacagta gcccttaaactaacacagtg
30301 accttgtgtc ttctgccaga gggatttgat cacactggtg aggaagggtcctggtccata
30361 ataacccaaa tttctgccag ggaagaggag attgaaaggt cccagtgatcttggcctatt
30421 tacttgggag ctcttccaca gaacaaatga actcctgaag atgagctgctacaaggattc
30481 tgtgctttgg acagaattgc acttgtctct tccccctgct gtcactccctgactaggaaa
30541 ggtccaagct gtgaaggaat cccccccaga agagacttgt aagcattaaagacctgtgga
30601 aaactaagag ggagggtgga tagaggagtc tggagaccga ctaaccttctgagctgctta
30661 ttgcctgaag tgggggtgga gtgggctgca aacactgttg tatttgggggacacatcaca
30721 gatgcttatt tgcaccttgg actttgtcag gacactctgg ttacagcacaactttgtgaa
30781 catggatcac aagatacttg gaaaagcagt gtttgcatta atcagattaggattagctaa
30841 aattttaatt aaagaaccag agagtacttc agaggcaagg agatgatagttacctgggat
30901 tacttgctat ttgtgaaacc aaccagctga ccacttgtgt tgtttgtcccaaggtataat
30961 aataactaga tgtttgcata ttgtgattgt ttctgttcgg atttaatggctgatctattt
31021 atcatattaa aagagggatc aagttcaaag atttcaatgc tctttatcttctttctatat
31081 atgatattta tttttaaatg tccatattaa atatacatat atacacacgattctcagaat
31141 tacgaagaat gtgctgtgta gcattcaatt atatatataa ttttttttttgagatggagt
31201 ttccctcttg ttgcccaggc tggagtgcaa cggcatgatc tcgggtcacagcaacctctg
31261 cctcccaggt tcaagtgatt ctcctacctc agcctcctga gtagctgggattacaggcat
31321 gtgccaccat gctgggctaa ttttgtattt ttagtagaga cggggtttctccatgttggt
31381 caggctggtc tcgaactccc aacctcaggt gatccaccgg cctctgcttcacaaagtgct
31441 gggattatag gcgtgagtca ccaagcctgg ctccaattct gtatatttttaaatgtaagt
31501 ataaagatca aagatacaaa gtatattcac atatcagttt ccatgttgttattattatta
31561 ttatttgcca ttttaaccat ctccagatga agaaaactga atgtaaagttaaatatctcc
31621 ttaactttta ctctatttaa aaagagactg aattatttgt gaggtaacccagttgtagct
31681 gttctactct tctctactgc tagattttgg aagaaccaaa aaggaataaagcaaagcatg
31741 acacagaaga gaaagcagaa ttatactgta gtagtatgct catattttatcagagtttgc
31801 ctgtactttt gctgattttt ttttctccta gcttggacat tttaaaggcttattttaaat
31861 ttatctcttc tgtattaaca ggtgagaagt ggacaaatca atgtataaaaactactatgg
31921 ctatcatcat ttagaatttt gtcttaaaag taattggatt tctggggtcctagacacata
31981 atgattagag atcatgccac cagttctata tggagccatc tcaattcatcctttctcaat
32041 ttatcctttc caggcatttt tcttgaaact gcctaagtac tggcgtctccctacgactat
32101 tatatctgaa aacacattca gttttcaaac cagctgaatt ttatgcctgactattccttt
32161 taacttatac caatgaaaat cctttaataa attcactcac aattgctccactttctcaaa
32221 cagagcacaa agcatctaac aatatttctt catgattgat agcatacacactcttgactt
32281 catattcttc aaaatcttgg tatttttata agcattagtg ccttttttttccccagtcag
32341 aagcactgac ggatttattc tattgggtgt tgtcttctgt ttggtctttagcttttctta
32401 gctgtgatcg tttattgctg aataattaag ggcaattctt tcccactgaaatacttttca
32461 agttaaacat tttttcctta aatttttgcc ccaggctact tctagatccagcgttgttcc
32521 agcttactga gcattccaga gggctaaggt ccaagttagc caaggttttaaaatgttgac
32581 catgtggacc tgaattcttt ccagttacat atttgcatac ttttaacaggagtggttatt
32641 tctcgtcaaa agacagaacg ctggaaatac cagggcaaaa ctatgtgtttttttcttggt
32701 gatatcttga tcttagcatt ttactctctc ttcctggttt ctagcttgacctttgtattt
32761 tagaggagag taatagagta acagtgcact gagaagcaat gggacatgacagaatagttt
32821 cagcagtgaa agtcagggaa gctggtttca accattcatt cacaagcttaaaggactttg
32881 gtatctgact ttgtggatgc cactttctca tctgtaaaat aagggggttggatcgtgtga
32941 tttataaggg gctttcttac tttctaacat tccatattct ataaagacagttaaagtctc
33001 cagagagtaa agaatgtaga aaattcctga aatttactca gctcctttattcctaaatat
33061 ttttgaattc tgaaattatt attattatta ttttttgaga tggagtctcactctgctgcc
33121 caggccaaag tgcgatggca caatctcagc tcactgcaat ctctgctgcccaggttcaag
33181 tgattctcct gcctcagtct tctgagtagc tgggattaca ggcatgtgccaccatgcctg
33241 gctaactttt gtattttcag tagagaaggg gtttcaccat gttggacagggtagtatcaa
33301 atttctgacc tcaagtgatc cacccgcctc ggcctcccaa agtgctggagttacagccaa
33361 agcacctgac ctgaattctg agttttgatt ctgttttttt ttttttttttttgagacaga
33421 gttttgctct tgtcacccag gctggagtgc aattgcacgt tctccgctcacagcaacctc
33481 catctcccgg gttcaagtga ttctcctgcc tcagcctccc aagtagatgggactaccacc
33541 gtgcctagct aataattttg tgtattttag tagagatggg atttcactgtgttagccagg
33601 atggtcttga tctcttgacc tcgtgaccct ccctccttgg cctcccaaagtgctgggatt
33661 acaggcgtga gatactgcgc ccggcccata ctcacagatt tctttgtgatattatctcat
33721 ttgttttcac cacacccaga tgatgtggat ggtaggagaa atcccatgcgaataagtgga
33781 atatgttagt aactgcttcc ttgggtcctt ttgcctctgg acttaactctttttttttga
33841 gacggagtct tgctctgtca cccatgctgg agtgcagtgg cgcaatcttggctcactgca
33901 acctctgcct cccagattca agcaattctc ctgcctcagc ctcccgagtagctgggatta
33961 caggcatgtg ctgccacgcc tggctaattt ttttgtattt ttagtagagatggggtttca
34021 ccatattccc caggctggtc tcaaactcct gaccttgtga tccacccaccttgaccaccc
34081 aaagtgctgg gattagaggc atgagccact gcacctggcc tggacttaactcttaaatga
34141 tgttacccag gaaaaccaat ctatgactaa ggcaaaaaaa aaaaaaaaaaaaaaaaaaaa
34201 aaaagttgca cagagaagag tggaaatatc agtaaatcag aagctaggcaggcctaatcc
34261 ctaatccact tggtgacctt ctgcaaaaca cctttctgtt agccttttcacccgtgaatt
34321 tttttttttt tttgagacgg agtttcgctt tggttagcca gactggagtacaatggtgcg
34381 atctcagctc actgcaacct tcgccttctg ggttcaaggg attctcctgcctcagcctcc
34441 tgagtagctg ggattacagg aacctgccat cacacccaga taatttttgtatttttagta
34501 gagatggggt ttcaccgtgt tggccaggct ggtcttgaac tcctgacctcaggtgatcca
34561 ccttcctcgg ctgcccaaag tgctgggatt acaggcgtga gtcactgtgcctggcttact
34621 tgtgaaatta aagcttcaac ttttactcct taggaacgtc tcacaaatttccacacataa
34681 atctaaagta gacactcctg cttgccaaaa gcatactctc taaaacattggttctcagac
34741 ggacatagtg gctcatgcct gtaatcccag cactttggga ggccgagacgggtggatcac
34801 ttgagatcag gagtttgaaa ccagcatggc caacatcgtg aaaccccatttctactgaaa
34861 atacaaaaaa aattagccag gtatggtggt gcgtgcctgt aatcccagctactcgggagg
34921 ccgaagcagg agaatcactt gaacctggga ggcggaggtt gcagtgagccagatcccgcc
34981 actgcactct agcctgggag atagagcgag actctgtctt ggaaacaaacaaacaaacaa
35041 acaaacaaaa aaattggttc ttgagcaggg caatttcacc tccaaggggacatttgacaa
35101 tggctgggga catttttggt tgtcacatct ggggttgggg agtgaagtgctattggcatc
35161 taatacgtag aggccaggga tgctgctgaa catcctgcag tgcacaggacagcccctgac
35221 agcattaaac agtccaaaat gtcaattgtt ttttgaggtt gagaaacgctggtctaaaag
35281 aaatgacagg acaggtggct tggctcatgc ctatcatccc agcactttgggaggctgagg
35341 cgagtggatc acctgaggcc agtagcttga gaccagcctg gccaacatggtgaaacctct
35401 tctctactaa aaatacaaac aatagccggg cgtggtggcc cacacctgtaatcccagcta
35461 ttcagaaggc caaggcagga gaatcgcttg aacccggggg gcaaagattgcagtgagcta
35521 agatcatgcc actgcactcc agcctgggtg acagagtgag actctcaaaaaaacaaacaa
35581 acaaaaaaac agaaatgact caaatgttta cagtgattac ttctggatgggattatgata
35641 attgtttctc tactgttcta aaaaactttc tgttctttcc aaatgtttaatattgagcac
35701 ttattttaca atcattaaac aaagaaatga caacaactgt taaaaaaaaattcttaagaa
35761 ctgaaaggca aacaccacca ccactaaagc catgtccccc agatctaggttgtgagtcac
35821 atgataccga cttcagaggc agcatgtctc aaggcctctc caatgtgtgtcagggacagc
35881 agtgggagta gggccctctg agtcagcctc tttgacctgg gatgctgcaggagatcttag
35941 caaacattca agattttcac tgagtcattt gcctgtggca ttgatctgctcactcaagtc
36001 ttccggtgtt ttggtgtgag ggaggctaaa gaggaaaaac agctgtttagtttctcattg
36061 atttgtattg tcattgagca atacctggag cccaagtgga tgtcttttattctgtggcct
36121 ccacagctgg gtcagtgtgg aaggcttcag accatgagaa attgttcctgggagtcaatt
36181 attttaataa gtgagatatc agagtatatt cacagaaaga ggcttccctggcactgtaag
36241 ggcagccagg aataaaataa aaatgcttct tcagtgaaga taattgtccaaattgaagac
36301 ataggaaata tttctaattt gcctgtgtat ttggtgaaca tttctctctctctctctctt
36361 tctctctttc tctctctctc tctctttctg tctccataaa tgaagacatgggaaaatcta
36421 ttaaaaatta aattaaaatg caacactttt acataaacaa aattcccaatcactctcctt
36481 actttacctc agcccaacca aatgtgagtt aaatctcttc cctttcccatgggacactag
36541 catcttggtg gcccagctca gtagctaagc atagagtaat gagtttgttaaataatttca
36601 attacattgt ttttgagatt ccagggtcac agggaaattc tgacctgaattatctggatg
36661 aactctcaca attgtgcact gccttgttca aatttgggaa gtgctgagaagcactcatcc
36721 aaggggtaga tctggacttc agctcatgca gcataataga atttcaggctcagtgatttc
36781 taatctgtta ccacttgcca ttttctactt gaagagggca gacaccttcactgatctctg
36841 tttctatttc atcttttgaa aaatcgggat gataatggtt atctggtttacatgctttta
36901 catgcttgtc aggagttatt ttaaagcact ttacaaatat aaaaatgtacaataaaattg
36961 cagagtcgga tgcagcaacc cctgtatcct ttgaggaatc tatcacaattcatacccctc
37021 ccaagccaac ttttctggta ctactctgga aaattgtgct tatacagttaaaatttttat
37081 tttcaaaaag ttgtgtaatt ccctttttca accatttttt tttgttataagaaatgcaat
37141 taaaaacata cttttctttc caaatagaag agcctattct gccttataagaattgtttga
37201 aagattgaag gacaaatgaa gtcatacaac ttctctgata ccatattgaactcaaatgaa
37261 cacattttga ggtaagaaat gagcctggaa gatttttctt ttttttttttttgagatgga
37321 gtcttgcttc gtcgcccagg ctggagtgca atggcgcaat cttggctcactgcaacctcc
37381 gcctcctggg ttcaagtgat tctcctgcct cagcctcctg agtagctgggattacaggag
37441 tgctccacca ggcctcacta attttttgta tttttagtac agatgggttttcaccatgtt
37501 ggccaggttg gtctcagact cctgacctca tgatccaccc gccttggcttcccaaagtgc
37561 tgggattaca ggcgtgagcc actgtgcctg gcaagagata gaatttttcacaaaaataac
37621 tcataccaga aactttgtag gcccccaccg atgcccataa tctttaggaaacaaactcta
37681 gtgtcaccta tttcctgata ccttctgtaa cgaccaggtc atattctgagttcctacagc
37741 actcagtgtt tctcatcgga gctgtagcaa tggagtaata aatggcactgctcaggaaga
37801 gagaattcag aaagaaaaga gcagggccta gaaaaggaac aaacttatcggatgtgtaga
37861 gaaagaatct gcaaagcaag taataaaatc cagaaaaacg tggtatcatggtggtcacaa
37921 aaaaaagagt ggttaaattt tcgaaaatgg agacaaacca ctcaccatgatcgtgccatc
37981 tgaatagaaa cacagaaatg atgacaaaaa aatggctaaa gaaagaaggtcaacaaccat
38041 gtccaatgct ttggatatta agaagtgttc agatggattt agcaagtagaaagtcactga
38101 cacttggtgc acaaccagac ctcaatgtat ttaggaggaa actgttattttggaacaatt
38161 gaaagctttc atttggctga gaaatatcaa ctcattctta aataggtatgttagaaggag
38221 cctctgggcc tgatatctcc ttgattacaa ggaaaatgaa taatagttgcgtctgataac
38281 catgacatat cacccctatg tttgcttgta gctttcagca gctcagaacattgttgaaaa
38341 cactcattat cccaatatcc ccaacaggga agtgttaaaa cctgccttgtgcaactgtca
38401 atctctgatg attagataaa aacaattatg tcatgagttg tagctattgttatttacttc
38461 ccaagagcca gattacacag gtatctgatt gctgaagcaa tgtctggatgtaccacgaaa
38521 ttccacatgc atgtacagta taaacacctc tggctatcac cttatctaattttgatcaga
38581 tacaggttaa tcccctcctg tatctttata tgtcctgaat ttgcctcatccacctgaact
38641 ttgccataat ttactctcaa tttgtatgtg tctgtgatgg agttgttgtcattttccttt
38701 tctttttctt ttttttgagg ccaagtctct ttctgtcacc cagactggagtgcaatgacg
38761 cgatctcagc tcactgcaac ctctgcctcc cgggttcaag taattcccctgcctcagcct
38821 cctaaatagc tgggactaca ggtgcatgcc accatgcctg gctaactttttgtattttta
38881 gtagagacgg ggttttaccg tgttagccag gatggtctct tgatccgcccgcctccgcct
38941 cccaaagtgc tgggattaca ggcatgagcc accgcgcccg gcctcattttctctatctgt
39001 ctgcttaatc aggttttgca agtttcacat ttcctcaact aaacttcattttaccaccca
39061 agcaaacttc attataatta ttttattttt ctgatgacat cagatttctgtaggggtacc
39121 tattagctag agatacttag attttatttt cccagcatgt gactatttcccattctatac
39181 aacacaatgg caagagcagg agtatgtttt tggacaatta aagagagaaaaggccgggcg
39241 cggtggccca tgcctgtaat cccagcactt tgggaggctg aggtgggcagatcatgaggt
39301 caggagatca ggagattgag accatcctgg ctaacacggt gaaaccccatctctactaaa
39361 aatgcaaaaa attagccggg cgtggtggtg ggcacctgta gtcccagctactctggaggg
39421 tgaggcagaa tggcgtgaac ccgggaggca cagcttgcag tgagccgagatcgtgccact
39481 gcactccagc ctgggcggca gagcgagact ccgtctcaaa aaaaaaaaaaaaaaaaaaaa
39541 gagagagaga aaataactca gcttcattta gatttctatt attcttctctgatccatata
39601 gtggatgttc acagaagtgt aggaaccaaa actatgcaag ttaaactgttaattttagaa
39661 gtttatagca gtgatgtgga aggctgacca aagttggcgc tttggtctcactataagcca
39721 tagtaataaa tacattaaca atgtccacaa acaacagtag acaccatttagtaagggctt
39781 gctccaagcc aggcactgtt ttcagcttaa gtctcacagc cttgtgaagtagattctgtc
39841 ccatcttaga gcaagttggt ctgaggatcc tcaagggtaa ggtctcttgccaaaggtcag
39901 cagaggtagt gagttcagaa ctgggattta aatccaggct gttctatttctattccacaa
39961 ttctgcctca actgcttctc tacattttag gcacacgttt gaatactgaaaatttgggtc
40021 acagagttgg agatgtttct tcttctaggc cccaaaccgg agcggggtgcagtggctcaa
40081 gcctgtaatc cgcactactt gggaagctga ggcgggagga tcgcttgagctcaggagttt
40141 gaagatacag tcagctatga tcctgccact gcactctagc ctgggcaacagaacaagatc
40201 ctatctctaa aaaaaaaaaa aaattaaaat tttaacacaa gggcccaaacaagtcaacag
40261 taattacaac atgatcttta ctactgtcta ataacatctc acagtgctttaaacatacgt
40321 agttaccatt ctgtccactt ggttgcctgt aatattaact cagtaagtaggaatacttcc
40381 tgccctgact aatatactca taaatatatg ctctaagtca agggtcttgcaggttctgat
40441 ttaaaaaaca caattttttt gagggtcact ggctttacat tatctcattcttttcaagtt
40501 cctttgtacg taaaacatcc tatgctcagt tatatgatct gttcaacctcctgcttgaca
40561 gatatgaaaa cagtgctctc atgtaattta tgtaatttac atttttacatatttagcagt
40621 acacctttgt gctatgttat attgtttgag aactaatctg tttttctgatggctggaagt
40681 ctaagtgaaa agattataca tgaaaataat tcatgtttat tatcactaggagaaagtaag
40741 acaatttagt ttgattcaca agcatttgaa tccctattgt gtcagacattgtattggaaa
40801 ctggggatac aaggaagata taacctcatc tctcagagtt ccctagttatcccatacata
40861 tatacaatta ttatttgtca attaaatttt ttttaaaaat ttagaaaggagtttccaagt
40921 aagaaaaatc atagcgaaat ggtataattg gtataataac agttaattagctatagtatg
40981 aaaatacaga ggaagatcta actaagttgg ggattattaa agaaaatttaaattagctgg
41041 gtgtggcggc agacgcctgt aaccccagct acttgggagg ctgaggcaggagaattgctt
41101 gaactcaggt ggtggaggtt gcagtgagat gagatcactg ggtaacagaacaagactccg
41161 tctcaaataa aataaaataa aaaataaaga aaattggaca gagatgtggcatttgaactg
41221 tctttcagat taagaagaaa gttactagtt agccaattca aatataagatttacaaacat
41281 agagtacagc atgagcaaag gtgtggaggt acaaaaagaa taatgtttttgaggggagaa
41341 tagcaagtac tctgggggtg gccaaagttt gagttgtgtg gttttggtggtggatggaga
41401 tgcaggaaga ttaggaagta gattgagatc agattgagaa aggtcttccagaccagatga
41461 aaaattttgc catatttagg caatagggag ccccagaaat tgttcaaccatcatcagctt
41521 tacatttcac tatggtaatt tggcttcata agaagcatgg gttggagattgataagagca
41581 gactccaagg ggccaattca ttaaactcaa ctgccaataa tgcaagagacaatgaaagcc
41641 agaatgaaca cagtgaccat ggatgccaga ggcatttcta ggatttttgtagaggactta
41701 agagaccatt tgggagggga ggaaggcaga agataagggg aaagaaggagttgatatctt
41761 tgatgactga tggcactttt gctaagatga agaataaatg gtagcaagaataaattgact
41821 gggcgcagtg gctcatgcct gtaatccaac cattttggga ggctgagatgggtggatcac
41881 ctgaggccag gagctcgaga ccagcctggc caacatggtg aaaccccatctctactaaaa
41941 ataaaaaaaa ttagctgggc atggtggcgg gtgcctgtaa tcccagctattcgggaggct
42001 gaggcaggag aatcgcttga acctcgaagg tggaggctgc agtgaacgagatcaagttat
42061 tgcattccag cctggacaac aggagcaaaa ctctggctca aaaaaaaaaaaaaaaaaaaa
42121 aaagtataaa ttgggggagg ggaggagata taggattcct attggaatgtattgagtttg
42181 agattccagc ctggacatat ggcactcttg aattgtttcc taggcgatcatatcactgtc
42241 ttgatgatat ctttaatcac acatatcact tgtggggaaa gaagaaacttcaagagtttt
42301 acacaccaat cctttacttt gccatctaga caaattatat ttttaccaatgccatttttt
42361 gttgttattt tgtgggttct gcttaaaact tcccctatat ttttctaattatggtaacct
42421 agggaaaaca tcaaattatg ttgataaaat tggctacaat ctggctctaatgataatagc
42481 ttagaatcat gaagcagcaa tattttatcc tgagagcaaa caaactttatcctgaacaca
42541 tgtgttcttt tgccttattc atctaatatt acttgaaact tttatttttccactttgaat
42601 agtagattct gccaagtgtt ttaaaagctt ttctcttttt aggggaggaggggaacagct
42661 tttctccctt ttgtctgata actgaggagt gaagatttaa ttggtgagaaaaatatacac
42721 actataaacc tcagaatgtt cccactgctt ttaatgtttg atgtgcctgacagattaccc
42781 tttcaaaaca gataatagga taggtggtgc tggaaaaaaa cttttccatccaagacaaaa
42841 ccacatggac attgaaaaga actggcattt gcctagacat ttagtgggggacatgtcctt
42901 agggcacaga ttccatagtg aaaggctctt ctcccccttc cacacactccagctctctct
42961 agaaggtata atggaaagaa ctctgagcaa gaatcaggaa gttggcctttgttcctgact
43021 gtgccacttt gtggaactgg gcagaactta cctcattctg tgctttagcagcttcatttg
43081 caaaaattaa tgattacctc aaatgatttc tgattttagc caaaattaaatacagtagtt
43141 ttaaaacaac tgctacatat taactactta cgtatgtaat tttgcactcaaaataaatta
43201 tattatggaa aagaaactca acctatgtta accatccctg tactgatgaggaaactaaga
43261 cttaggaaaa agaagtgatt tactcagtat tgggcagtta gtgagcatttttgagccaag
43321 gtcttacttt aaccagagac ctttgcataa tattgtactg ttactaaacactttctatta
43381 tttgactaga ggaacacaac atattgatgc atttgaaaca ataaaataataaatattttt
43441 ccttaccctc ggcagaaaca ggatgatgag aaacattgac taaaaatttaatcaagcctt
43501 aaggacaaat agtatcacag ttttgaatag gagattgggt accttggaagtaattatgaa
43561 gaggtgtttt aactcagcag taggctcttt cttattcctg ctaggaatgaagaagcacaa
43621 attgaaagtg aagaaggagg aaataaaaca ctgactctat gtgtaagaaaggtgacttgc
43681 aaattatgag gcagttagga aaatgtttat tttttcttat tttataggctgtatatattt
43741 gagaattaat aattgtcctt tggagggtgt gtgtgtatgt gtatgttggagctttgtgtg
43801 tgttttagtc cattttccta ctgctatgtg aagaaatgcc cgagacggtaatttataaag
43861 aaaaagaggt ttaacggact caccgttcca catggctgtg gaggcctcacaatcatggtg
43921 gaaggtgaag gaggagcaaa ggcacatctt acatggtggc aggcaagagcgtgtgtgcag
43981 gggaattgcc ctttataaaa ccatcggatc tcacgagact tattcactatcacaaggaca
44041 gcatgggaaa aacttatccc catgattcaa ttacctccca ccagctcccctcaagacaca
44101 tggggattat gggagctaca attcaagatg agatttgggt ggggacacagccaaactgta
44161 tcagtatgcc tgtgtgtatg catgtgcacg tatataaatt ttttcactagtgactgatgg
44221 accatctata aaataaacaa aagagaagag acagggtctc actttgcctcctaggctgga
44281 atacaatggc atgaccatag ctcattgcag cctctaattc ctgggctcaagtgatcctcc
44341 cttctgagta gctgggatta caggcacgtg ccattatgcc caactaatgttttgtttgtt
44401 tgttgtggag atgggagatg ggagtactgc tatgttactc aggctggtcttgaactcact
44461 cctggcctta agtgatcctc tggctttagc atcctaaacc actacaatcttaaaaaggac
44521 cagtttcctg gattacctct ctccctccat catccactat ctgccgtcaactctatagag
44581 tcaagggcta tccctgcctt ttcaatagaa gccctcaaga agtcactccatagggactat
44641 cttgggcttt gggaagtgta cagggttggg gtgggtggga aggtgaggaggaaaggccac
44701 tgtttcaggt ggggttggag ggagatggaa aatggaccac agaggttcagagaacaggcc
44761 ctttgtggaa agggggagac caaataatgc tgcgttgtga aaggtgaaacaggctgcaaa
44821 cagaaggagc ccacaggaag ccctgctctg agcagctgaa cattctggggtcctcagact
44881 ccgataaaaa agcacattta gcctacagct ttatgccctt cctcctacccttgtggactc
44941 tgccacagac atgccctcca gattgattct atccacttgt ctctagtctactgctactat
45001 tttagtctaa ggccttctcc ccgctttcct gggttatggt cacagactcctatctgagtt
45061 cccagcacca ggtgcccagt tgttttcatc tcttaacaca ttccacatattatagcaaga
45121 gagatctttc tcaaatgcaa atcagacctt gttgcatccc aatctcaacccctttagttg
45181 ctcttctctt tgccctcatg gtcaagttca agctctctag tgtgggggcagatgttcctt
45241 tataattttt ctgcttatgt ctcctgcctc aggcctcaca attctccacctcacagatga
45301 tgtctcagcc atgatgagtt cctctcaaat cctttaggtt tcagagatgtcatttcccct
45361 gggaacattt tcctgactcc tcgttccaag catatgtctg tctttatgttcccatagcac
45421 ctgatcattg gatcatggta gggtttatca cggtctcgta tttgtctgcttacttgtctg
45481 tattcttcac ttctcaaata tgtcttcttt gttcatcact gtaactcctttccccagaat
45541 gttctcagat atttacaccc atcttccccc tctgtgaagg gaataaatggatatataaca
45601 ctgtattagt ccattctcat gccactatga agaaatatcc aagactgggtaatttataaa
45661 gaaaagaggt ttaaatgatt acagttctgc atggttgggg agaactcaggaaacttacaa
45721 ttatggcaga ggcacctctt cacggggtgg cgggagagag aataagtgcaagtaggagaa
45781 atgccagatg cttctaaaac tatcagatct catgagactc actcactatcacaagaacag
45841 cacgggggaa accgcccccc atgatccgat tgcctctacc tggttccaccctagacatgg
45901 tgattatggg aattaaaatc caaggtgaaa ttttggtggg gatacagagccaaaccatat
45961 taagcaccat cctcaaaata gccttccagc tgaagacagc taaggcactcatgtagtctt
46021 attttgtctc agacaaataa ttttaccttt gaatcattgt tcattaatctagattttaac
46081 ctgaggccct aaaaattgtt tatcatcttc tgggagatct tactcctagatggtgtttta
46141 ttccacaggt taaatttaaa cttgggccaa atctccatcc ttgtggcctgtgagtactga
46201 atttgggact gaaagcctgg gactaactgg aagtgtggaa aaggaggagggtgtggcgct
46261 gccctcaatg attttttttt ttttttagga tttctggtgg aaaaggagagacactcagga
46321 atccccagat aaacatggtt tagcttttgt agtcagatcc tttccccaaatttactgctt
46381 ctttctccac cacttctcaa ccccccaaac tgaacttgcc tcttcaacacactcccttgt
46441 gccctataga cagtcacaag cttgacctat agagagcatg tatttcttgaggcaacgaag
46501 gtaggaaacc ctattctaaa atgtttctta cacttttggc tctgtctaaattctccattt
46561 ttcaattaaa atggaaacga gattagaatt ctattctagt tatgaatataatcagaacac
46621 aataaagcag aaagattgct tcaggctctt ctgttaacgt tacatttattcaacaactct
46681 ttatggggac ttgctatgag tgaggcacca ggctaggcac cgcagctacaaaggtgaaga
46741 gaacataggc tcttcttcaa agaaacttac actgtaagct ttatagttatgaaatcatga
46801 ttgcttacct taaatgttct tgacctacat tcttagatat tttgagtcttgagaaatttg
46861 tttatttttt tcattattat acaatgtcaa ttagctcagt ggaatccaagatgttcggct
46921 agccttctga tccaagatag tggaccaaac atttgtattt actcattgtgcccctccata
46981 cttctctgaa ataaaagtgt agatcttcaa aattaaacat atctataaagcaaagggaac
47041 agaaggggac attatcagca gattagacat tccaaaaatt ttttagaaaataaaagctaa
47101 attgaatagt aagacacgga attattagat gtgtttggaa aaccaacagcatgaacaaga
47161 taatccaaga aaaacaagtt gtcccttggt gaaaatggaa ggaatttgagaaatatagaa
47221 gtgaactaaa caataaatac agtcatccct tggtatctgt tggggactgattccaggacc
47281 tccctcagat accaaaattt ggatgcccaa gtctctgata taaaatggtacagtatttgc
47341 atacagccta tgcacatcct actgtatact ttaaatcatc tttagattacttataatacc
47401 taatacaatg taaatgcttt gtaaatactt gttatattgt attgtttagggaataatgag
47461 aggaaaaaaa gtctgttcat gttcagtaca gatgcaactt tttttttttccagaatcttt
47521 ttaacctatg gttggttgga atccacaaat gtagaacccg gctacagagagctgactgta
47581 attaaaacca acagcttcta tttggtatac tgaaagagaa ttgggaaatcattaaatcca
47641 taaaataaga acaggatgga gtgaaaaaag ctggactctg tgacgaaatggacatatgta
47701 tggataagaa tcaggaaagt tttcataaag gaagtgccaa actgagctagttggccaaat
47761 gaactattct ccaggtggat ggggcagggc atttaggcag aggaagcaacaaagcacaga
47821 gtgaagccca ggaaactaca ggtagctgca gggagatgac ggggctacagtgtgcatgga
47881 gagaggccaa catggtgagg taggcaggag gagctcctga agggctccaacctgggaagc
47941 caggctaaag agatggcatt ctatcttgtc agtaataaga agcattgacattttgtagag
48001 atgatgaatt gaggaaggga tttatgtggt catttgtggt tctggctgatccccctgagt
48061 gctgtctgct agaaggattc caagggttaa gtcctgaggc gtgaagaagaaccgatctgt
48121 aagatagctt aactaaggtg gtagcattgg gataagggtg tggggtgtgtgtgtgagggg
48181 gatacaaagt tattaaggtg gtagaattga tggcaacatt catcttgacagagaatacag
48241 gatgaggagc agatttcaga ggaatataat gagccctttt ttagatctttgtgaatgttc
48301 agaaatggca gctggtgttg cataattgca aaattagggc ttagttagttattggcttct
48361 gagaacgtaa ctgcagtttt tttctttccc tctgccccac tctttgaaagggggtggggc
48421 tcaaagagta gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtggtaaatacttatata
48481 caaatttctt tagatttttc tttatctcct tcactccttt tcaacattttggctggttgt
48541 tctgatatta ccaaggtaat ccacaattat ggcaaatatt caaacaaaacaaattataga
48601 aagtccagaa aaaaaaactc tgaaatacct tttccagaga ccaccatcatgaacagtttg
48661 gtctacagaa ttacaaatct tttgaagtat atagtatatt cttttatgtggccattcatt
48721 atattttatg ggatcttagt attattgctt ttaaattcat ttcttatattttaaatttga
48781 aatacttcaa aatatgcaga aaagtagaga aaataacatt aacaccatatacttaccatg
48841 tagatttaag agaaatctac actttgccaa atttcctttt tttttttttttttttttttt
48901 ttttttgaga cagagtcttg ctctgtcacc caggctggag tgcagtggtgcgatctcggc
48961 ttactgcaac ctctgcctct tgggttcaag caattctcct gcctcagcctcctgagtagc
49021 tgggattaca ggtactcacc accatgcttg gctaattttt gtatttttagtagagatggg
49081 gttttgccat gttggccagg ctggtctcga actcctgacc tcaaatgatccacctgcctc
49141 ggcctcccaa agtgctggga ttacaggcat gagccaccgc acccgaccaaatctccattt
49201 ttgtaaataa tttttcagat atagaaaact acccaattat ggctgggcatggtggctcat
49261 ggctataatc ccagcacatt gggaggccaa ggcaggcgga tcatttgaggtcaggagttc
49321 gagaccagcc tggccaacat ggtgaaatcc cgcctctaca aaaaatataaaaattagccg
49381 ggcatggtgg caggtgcctg tagtcccagc tacttgggag gctgagggaggaaaatcact
49441 tgaacctggg aggcggaggt tgcagtgagc tgagatagca ccattgcactccagactggg
49501 tgacagaaca agactctgtc tcaaaaaaaa gaaaagaaaa gtaagaaaactacctgatta
49561 ctattacttc tctctttctc tctctctctc tgtgttctag aggtttgcagtatcctgaag
49621 ctggtgtgaa tcaacctcac gctttttttt tttttctttt tttttgaggtggagtctcgc
49681 tctgtcgccc aggctggagt gcaatggtgc aatcttggct cactgcacctccacctcctg
49741 ggttcaagtg attctcctgc ctcagcctcc cgagtggctg tgattacaggcatacaccgc
49801 catgcccagc taattttttg tatttttagt aaagatgggg tttcaccatgttggccaggc
49861 tggtctacaa atgtatctat ccataagcaa taccgtatat agtaatatttttattattct
49921 attatttcta ttgaatgttt atattcatag tatcacactg tacacatccttttgcaattt
49981 gctttcttta gaagcaacaa tatatttttg agatttatca tgttgctttgtgtagattgc
50041 ttactttttt tttttgatgg agtttccctc ttgttgctta ggctggagtgcaatggcgta
50101 atctcggctc accgcaacct ctgcctcctg gattcaagag atcctcctgcctcagcctct
50161 tgagtagctg ggattacagg catgtactac cacactcggc taattttgtatttttagtag
50221 agatgggctt tctccatgtt ggtcaagctg gtctcgaact cccaacctcaggtgatctgc
50281 ccgcctgggc ctcccaaagt gctgggatta caggtgtgag ccactgtgcttggccaatta
50341 tttacttttt aatttatttt atgatacaca atttgtctct ttatctcactttattttttg
50401 attttttttt ttttaaacca ggatctcact tggtcaccca ggctggagtgcagtggcgtg
50461 atctcggctc actgcatccc ctgcctccca ggtgcaagca attctcctgccttggcctcc
50521 tgagtagcta ggactatagg gtgtaccacc acatctggtt aatttttgtattttagtaga
50581 gatggtattt tgtcatattg gccaggctgg tcttgaactg ctggcttcgagcaatttgcc
50641 cgccttggcc tccaaactct ctttattttt tagatattgt taacggtactatgggcagta
50701 tccttgaaca tctctctttg tataaatgtg aaagacattc atagacatgggactaaagga
50761 ggtgcccata gtcaaccatg ctaggcattg acaaatggct tcctaaaggggtaatacctg
50821 tgtacattgc cactagcaat ttgtacactt tcttgattcc tttcactcttgtcaaaactt
50881 actctttttt aaatttaaaa ttattggcca ggccatggtg gttcatgactgtaatctccc
50941 agcactttgg gaggctgagg caggtggatc acctgaaatc aggagtttgagaccagcctg
51001 gccaaacatg gtgaaaccct gtctctacta aaagtagaaa aattaactgggcatggtggt
51061 gggtgcttgt aataccagat actcgggagg ctgaggcagg agaatcgtttgaacctggga
51121 ggtggaggct gtggtaagcc aagatcacac cattgcactc caacacaggggacagagtga
51181 gactctgtct caaaaataaa ataaaataaa ataattgtca atattgttggttatgaaatg
51241 ctatctcatt attgtttaaa gaggcatttc ccttgataac tagtgaggttgaattttgtt
51301 ttccagatgt gcatgagcca ttggtttttt tctgttatgc attttctattcatatacttt
51361 gaccacatga tatgtgcctg gtcataaccc atcaaactct tctttctctcagatacttca
51421 ctttatggaa atctttttca cgtttatccc tcaaacccag aattttgagtgtcatacctg
51481 ttctaacata aatttgagga aaatgaaggc taattcagaa taaagaactatataagcaga
51541 tggacagtgt gttctcctct aaataggggt gctaggataa gaggcggtaggataaatgca
51601 cagcctcaaa atccaccacc cactaaagac ctcacagtac atgatgacattagcatgctg
51661 tgccagcatt tctacctacc acgatgacct ggaatgaagg acaaaaggggcaattgttaa
51721 gtcctgtgcg taaactttgg aagagaacat accttgcttt aaaccattaagggggcaggc
51781 aatagattcc tgtacagggt ggcttagcca aaagtggctg gtcttgttctcatttatatg
51841 gtttataatg attctaaatc attctcggag aaaaacagac tcatttcatctccctttaat
51901 taggatttct gttactgcaa tattttagtg gcatttatgt caaatgttttcttttgagaa
51961 cttctccctt ttactgtctt ttttctttta ttttaaactt ttattttaggttagggggta
52021 catgtgaaaa ttggttacat aggtaaactc atgtcaagag ggtttgttgtacggatgatt
52081 catcacccag ggattaagct cagtactcaa tagttatctt ttctgctcctctccctcctc
52141 ctactttcca ccctcaagta gaccccagag tctgttgttt tcttctttgtgttcataagt
52201 tctcataatt tagctcccac ttatatgtga gaacacgcag tatatgattttctgttcctg
52261 cgttagtttg ctgatgataa tagcctccag ctccatccat gttcctgcaaaagccatgat
52321 cttgttcctt ttaatttact ttttgctatt ctgattagag agtggccatgctccatgctc
52381 catatggata ttctttggaa acaaagcatt tttgaaatgg taggattggggctagtaaaa
52441 gagaacagaa agaattgtga acagggtctc ctccagtaca gatggttaaagaacacaaat
52501 agggaagtgt gatgagtgac ctccatttaa ttgggcgccc aagctcttggctgctccagc
52561 atgggttgcc atcctgactg atcccttggc tcagaaacag atatggtgctatcaggaaag
52621 caaggccaat atctgaatat tgcagcagag actgctccca tttcagaaagcaacccagat
52681 taaagttgat gattcagttt caataaatgc ttcctttttt ataaaaggcatttaacatca
52741 ctctttcccc tggtaatatg gaattagctt ttgggatcaa ctggaaaatgtcagagggcg
52801 attgtaaaag gccacctgct aaccacagga agctgggctg atacagaatgccaggttaac
52861 ttaaggtcga taatggttac ttccttgtca ctttttacat gcatccttgctctgcagtgg
52921 gggtcataag aagtaagatg catgcaaggt gaatttctag aagtcagcttctctgagaag
52981 tattctctga ccatacattc ctactagtcc ccacatacgc tgctgatctccccatcttca
53041 cccccattgt tgaaattgct ccctcattgt aactgttcac tcatctgtctccaccataaa
53101 gcttaggctc ctagaaagtc aggaccagag ctagtacagt gccccatgttcttatggaat
53161 gattttagtg ccttgagttt ggtgtggtga ccagagctgg tggccaactgtcgtgaggcc
53221 ccagtccttc tttttgtcat gctttccctc ccagcccctc cttgaccactctttcacctc
53281 catctttcta cttatataga gacaaataat aagatgcttg tacaaagggtgtacttgtat
53341 tatcccattt gtgttgatat tccacaacag caaattaggt ttttttgtttgtttgttttt
53401 tgatggagtc ttgctctgtt gcccaggctg gagtgcaatg cgtgatctcggctcactgca
53461 acctctgcct cccgggttca agtgattctc ctgcctcagc ctcccgagtagctaggacta
53521 caggcaccca ccaccaagcc cggctaattt ttgtattttt agtactgacggggtttcacc
53581 atattggcca ggctggtctt gaactcctga cctcaggtga tctgcccgcctcggcctccc
53641 aaagtgctgg gattacacgt gtgagccact gtgcctggcc tgataaggtttaaagattaa
53701 ataccatgtc gttaaatttg caaatctctc gaataggaaa atcaggaacaatgacaacat
53761 tcggagcttc ccagaaggta acaactatgg ggagttttgt gggcatctgagagaagcaca
53821 cacacagatg gtttgccttt cattggtcca ttcttgccca gaaggcgacactaactgaaa
53881 caaagaagcc tcatatgaga aggacatggg gtcacagcag cttttggggtggccctgggt
53941 ccttgatctg gtctttctct ggctcatttt gtattgctca ctttgttacttcacaatcca
54001 gggcttgtga catttttctt ctctggagtg gaaatgacag agctgcagaacacaagtttc
54061 tgattggttc ctatgagtca ggaaagaggg ccagttgaaa ctgggctcacacacacacac
54121 acacacaaac taggctcaca tgtgttttcc catcagctaa acaagttttcagaagtacag
54181 aaataactcg ttggggaagg ggacccagga caatgacaat gtttttgatggtaatgtctg
54241 cagaagtaag gcaggtttcc tctgtgcctg aaaagatggc accatttgaggagatggcat
54301 actcgtggtg gaatcttcat taagatgtca aactaagctg taggaaatcaactctagaaa
54361 acagctctaa tgtgagaaaa catatatcca gttttataga gcaagagctgtgatcatggt
54421 gacatttaac aactgtatta gttggccaag agggtaaaaa tatacttgacctcttagagc
54481 accataaata ctctcagctt gtgggccaac tgtgtcatgg tcttttttctagcccctcct
54541 ctttctccct tccttcttgt ctctctcctc ctctctcttc cctcccctttctcctttctg
54601 accctctttt ctcttctcta tcttctcgaa ccttcccttc ctcctctcctttaggtgctc
54661 agcacctctt tgattcaata aacatttacg gagctccttc ttgtgccaacgactgtacac
54721 agagctggga tgtcaagatg aatcagttac atttcctgcc caatgccaagggatggcttg
54781 atgggttttg accagcccct ccctggactc ccaatttctt ttttttttttttcttttttt
54841 tttttagacg gagtcttgct ctgttgccag gctggagtgc agtggcacgatctcggctca
54901 ctgcagtctc tgtctccctc ccaacttcaa gcgattctcc tgctcagcctctcgagtatc
54961 tgggattgca ggcatgcgcc accacaccca gctaattttt ttgtatttttagtagagaca
55021 gggtttcacc atgttggcca gggtggtctg gatctcctga cctcgtgatccacccgcctt
55081 ggcttcccaa agtgctggga atacagtcat gagccaccgc gcccggtgccctggactccc
55141 aatttctacc tcctggaacg tgctttactc accagccttg gtgttattctgcaatatggc
55201 caactgggat ttttttcaat cttacagaaa ttattctcgg aaatgtttgctatttttttt
55261 taatgaagct acagcataca atttaaggat aaataatgta cttactctgcagctattgtt
55321 tcaagtcaaa tccgctgatt actcctccaa aattcttttc ttaataaaatctctgaccct
55381 ttcctcttcc tgttagaact tctggagcta ccattgttcc tcctcttgggctgctcataa
55441 cctaggggag tcacagtgaa attacttgct ttaaaattct ttaatcactctgcgagttgt
55501 taggaaaagc tgacacatct gatttggaaa ctcccactcc agtggactgttgtgcctcag
55561 cacacaggga cgggtggagc aaaggaacaa gaagccaaaa actctcagggcacttactat
55621 gattgtgtaa aagagagact catcaattaa cacaggtact ggcaagtgcacttcataatg
55681 cctccatttc tagacagatc aaaaacagtg tgccctgtca ataaatgctgagtttctgta
55741 gcagcctgat tgagatcagc taacctttag gccaaaagcg ggattcttccttgctgaagc
55801 ttttggcaaa gcatattgag cttcatgcca gggattagat taactcttgcaaaactggtt
55861 caccaggaac aatgactcag tgtttttttt ttagtatccg gcatattgtgtggagcagct
55921 ataaatatat ttacaagctg gagtttcaag ggaggggagt aatagcttgctgaaaaacat
55981 gccaactgag ttatgggtct tcacgcagcc agcatgctgt gttttgggctctgcctcttg
56041 taatttttag aaattaatta gtttattctt tatttatatt tatttatttatttattttca
56101 gatgggatct tactctgttg cccaggctgg agtgcagtgg tgcgatctcggctctctgca
56161 acctccgcct cccaggttca agtgattctc ctgcctcggc ctcctgagtagctgggattt
56221 caggtatgcc tcaccatgcc tggctgattt ttgtattttt agtagaggcagggtttcacc
56281 atgttggtca ggctggactt gaactcctga cctcaagtga tccacctaagggtactggga
56341 ttacaggcat gaaccactgc acccggcctg ttggttgtaa ttttattttcctcctcaagg
56401 actttgagca cattatcttc tctttaataa cttgtttcca ccctcctttgtgcacgcgcg
56461 cacgcgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtattttctgatctccc
56521 tacgggggca gagagtctca agcaggtatg tccatgttat taacatactgtctgcttatt
56581 aactaactgc accaatgatg aaagccaact gacaaacaag tgatgctcttatccctcctt
56641 cgcaagcaat gaatctgaaa gccaagagaa gttttccttt caacaggaagtgttttggag
56701 tccgaacaac tctgcattta gacagtgcag cttttagtta cagatcttggcaatggggca
56761 ggcagaggga gcggcaacta cagactttgc cgtaggactg ttttctatggagtgtgtgtg
56821 ctctgacgag ctagtgacag gagggaggtt acaaaagcat ttactgaaataaggatttct
56881 aatagaggag ctttttaaaa gtattaaata tgctaatgtg cctagggcatagtcaacaaa
56941 gagttataat acatgtcatt tttcatattt atcaaggaaa ccatgtcacccgcagccttt
57001 ctcaatttct ggcattctga gaaacacact gtagtggtgc ctgagggtctggggaaagaa
57061 gaatagaatg aatggggcat ctcagaatcg taaactcccc cagttgtagttcctttcgat
57121 gttggtcgtt ggatgaattt ccagtttcta ctattgtggt tggattggggagagtagctc
57181 aaattgggaa ttgctttttg aggatctagg gcttctggaa ttctcccagtttctttttac
57241 ctctttatgc tatcttgtct actttgaaaa atcagtagca tccatttgattgcagagctg
57301 aatctttcta tacagtgagg agttgtaatc acattactta taacctgcttatttaacttt
57361 ttaaaggtgc aagtcattgt aacctaagta tttactcaca ctgatccttaatatactccc
57421 ctttcttatc tgcaagcttc tttctctggt ttctcctaac tctgttactgctcatgagtt
57481 taaaactttg tcttctcagt tcctggcttc acctgtttgg tctctgctctccaggactct
57541 gccttggaaa tctgactcac acttctatat gtccctgggg ctcaacttcgggcctggcgc
57601 cagaatcacc caggctccaa gcaagccttg tagactccac tcagtcctttgactcaagga
57661 aatctccact tctaaatggc tctccggttg attctgatgc cagtccagggttgagaacca
57721 ccgctttagc ttctagacac acagccccct cccctttttc ctggagcccctcttgggtca
57781 tgattctatt ttccctattt ctgtactcag aagggataaa aatggaagtgtatgtgaagt
57841 tgctactacg tcccaggtgc tttaaatatg ttattttatt caatcttcacaacagtctta
57901 tgcagtctct atttttattt taagaatgag gaaaacaata cttgggtgcagtggcttatg
57961 tttgtaatcc cagcactttg ggaggccaag gtgggtagat cacttgagcccaggagttca
58021 agaccagcct gggcaacatg gcataaccct gtctctacca acaatacgaaaattagccag
58081 tctcataacc tggtctataa ataaataaat agataaaaat ttaaaaataaaataatttaa
58141 aaagaaaaga atgaggaaaa caagattcag agagccttgg tcatcttcccaaaggtgcac
58201 aattaagaaa tggctaagca ggggttctga ctcagatctg tcagcatctacagctttgct
58261 atttaaaaga gcgtggtccg tggactagca gaatcagtgt cacctgggatcttggtagaa
58321 acacaaatac ttgagtgcca tctcagacgt actgaatcag tttcttcaggggtagggtcc
58381 aggaatatgc attttatgaa ggcctctaaa tgtttctcaa agtttaagaagcatggggaa
58441 ctatatcttt tcctactata tagtcttatc tctttccttg tttctttactccaaagtatt
58501 gccttatttc tttcccagaa acctcactat cagctcactg tgcagccttactcatatctt
58561 cctcaaccag cagttttatt acacacaccc ttctcatttc ctcacattgctcatggtatc
58621 tgactgagta cagggatcca acctggcttt gggttttgca ctgtcttgcctcagtctctt
58681 aatttcttcc tatgtacatt ttaagatatt gaagacacta acttccaaacctcttctcta
58741 aatctgacag tgaagcagtg tgtgtgtgtg tgtgtgtgtg tgcatgccagtgcatacacc
58801 acacatacaa gcacatacac agagttaagt ttggtcacat ttacttcattaattgatata
58861 taccacaact gagaaaaact tactggcatt ctgctccaag cttgaattcccagacgaaaa
58921 acaaacaagc aaacaaacaa ctcctcctta cacaaaaata tctagtggccttggaaaatt
58981 ccatttaaca ttaaattgtg tctcttcaaa gtgaagcagg gtgggcagatttttgaacat
59041 gaatctactg ataacacaac acctcttcaa aactagaatc tcattcagggttaaatgatg
59101 tccaagtcaa acctgagatg ctagcatgat gccccatcct cagtcagaggtttcagggtg
59161 gcaaacaact tttgctcact ctcctctgcc tctctctata tttgcagaaagtccagcttt
59221 cactgcaaaa gttcgataac tctgtaaaac agtttgatcc taacttcaaaagaattttta
59281 tgctatttgg aatacataaa aaatgaattt attccaatac tttagccccataaataatgc
59341 ataatgattg gtgaaagatt agcattttgg agttcaagta cttaaagctttcttggatgg
59401 ataatgcatc acccttaact agcataaggg gaaatagaag gttgacaaggaaaacttaat
59461 ttagggttct ttatttattt ttctctagtt atgtttacct tcccaggttgttttattaat
59521 gccacttttc acaaggatat ttcatgaata aatatcaggt tgtatctctggccatctgtg
59581 atgatcacgt ttttattttt aatgagttgc tcatggatta tatcctaactggaattgcag
59641 tcagtatatt gagatgcatt gactccattt ctgtctttca ttcttctttctcaatgtatt
59701 ctcactggat tagcactctt agccctgagg actcttgggc cagttttattactaaaagaa
59761 gaattacagt tttgctacac agtgaccttg caagaagtat cagcacagctcaatttcaaa
59821 ttctcctcaa atatcaaata tgttcttggt atattttgct tagcagtttattgccttctc
59881 atctccactg tttttcctga gtaacagctc agaaatctat aaataaaacttaataatggg
59941 gagtgactca aaagtctggt tatttttatt agtaaactat tttaggggtgaacacttcac
60001 attttacatt ctcatgctcc acagtgctga aaatagtctg aattttttttgtgtgttagg
60061 ttgatgagaa tatttttgag atgactagca gaaaacagaa tcattaaaacagtgctatca
60121 gttttcatgt tgaataactt tacaggaaat gatagcatct ttttttctttttttgagacg
60181 gagtttcgct cttgttgctc aggatgaagt gcaatggcgc gatctcggctcaccgcaacc
60241 tccgcctcct gggttcaagc gattcttctg cttcagcctc ccgagtagctgggattacag
60301 gcatgcgcca ccatgcctgg ctaattttgt acttttagtg gagatggggtttctccatct
60361 tggtcaggct ggtctctaat tcccgacctc aggtgatcca cccgcctcagtctcccaaag
60421 tgctgggatt acaggcgtga gccactgtgc tcagccgata gcatcttaacaataaacatg
60481 caaagatttg taaatgttgg caaacagcaa gaaaaacata tttagaaaattgtgctatgc
60541 tttaatgtcc tgtctgtacg ataatttact tagctcccta ccttccccccagcccaccag
60601 aatgtttaaa ctgaaattta aagcacagtt gatcttggct tggataggcagcctgcatat
60661 taactgagga tttagttagt atccaggagc agatctactt ctcaaagtgagattcacata
60721 gcccccttgg aagctttcaa atagattgac tagcctttta aaattcctcttctccccttt
60781 cttattgccc ccgccttgtc tagctgtatg ctaacttgct gcatagaatcctgaatttct
60841 ggatttctac atttctagct caatgaatgg ggtaaatcaa aacttaataacactcttgat
60901 tttgaaaagc ttcagtgctt catgtaagac tttttgagaa aagatcattttcatttattt
60961 ctgttttatt tctagcttaa tgattaaatg taagctgttc aatacctttttcaatatccc
61021 acttgttaaa cccacactaa acctcagaaa tattgagtca gtgatctaaatttccattca
61081 aaatttccac aaagcagaag cataaatgtt ttcattgtca ttacaaataaacagacaggg
61141 ctgggcgcag tggttcatgc ctgtaatccc agcagtttgg gaagctgaggtaggcggatc
61201 acttgaggtc aggagtttga gaccagcctg gccaacatgg tgaaacactgtctctactaa
61261 aaatacaaaa aaattagctg gattggtggt gtgtgcctgt gatcccagctactcaggagg
61321 ctgaggtagg agaatcactt gaacctggga ggcggaggtt gcaatgagctgagattgtgc61381 cactgcactc cagcctgggt gacagagtga gacttcatct caaaaaacaa
aaacaaaaac
61441 aaaaacaacc ccttcccctc cacgaaagaa aaccccaaat aaacagacaaatgaaagcaa
61501 tgaaaacagg aaaataattt tgacacctac ttctgggatg ttatgttatgctttgcattg
61561 gttctattta ttagacatgt tcccatcttt attatttaag agcagataaaataacctcac
61621 tacattaatc tcttttgctc tgcctctttc catatgattc ttcactagcagttcccaaaa
61681 caaaaaaatt gtgcaccaaa atcccaactg agactcaatt gtttgctgactcaacaactc
61741 taatgagaaa tcttatacaa gagcttttgt ttcaaaagga agtgccaggaaaattttgct
61801 tccctcaagc aatggcatgt tttctttttc tggacagtga gaaccatgtaattaaacata
61861 ttttcctttg tgctttggct gtcaggaaac tcagagccaa acttgtagcccaagttttat
61921 ggctatgtaa gacattatgg cccatatatc tggactcttc ctttctccttggtattgatc
61981 ttcagtcttg gctttagttt acaaaatatg ccattataaa aaataacagtatctgtaggc
62041 tgtctgaaat tattatggaa aaagtagtgt acaaataaat gaataagtcaattgtttgaa
62101 aaacaatgca tttgtatcag aaataacttt gtgagtggtc ttcaggttcctagtctattt
62161 cattttgata tatatttctt gtgggtttac cacgtgccag acaaagatgttcctggcagg
62221 ggggttaata atgttaacag tactcagtct ttctagtgcc ttacaggctatagaaggaga
62281 aagaaataca aaacaaacta aaataggtat tcaattgcaa caaaagcaacttgatgtagg
62341 ggtacagggg aaggaataat tcattctaca ggcctttaaa agataaagaggtatttcaaa
62401 ggcaaacaat ggagagaaga tcattctaag ctaaggaggt tgcatgaagaaagcataatg
62461 tcactacttt tttttttttt tttgagacag ggtctggctc tgttacccaggctgtagtgc
62521 agtgatgaga tcacaggtca ctgcaacctc caccttcagg gctcaaaccatccttccaca
62581 tcaacctccc aagtagctgg gactacagct gcatgccacc atacccagataatttctttt
62641 attttttgtg gaaacagggt tttgccatgt tgctcaggct ggtcttgaactcctgagctc
62701 aagtgatctg cccaccttgg cctcccaagg tgttgagatt acaggcatgagccaccgcac
62761 ccagcataat gtcatcaaat tgaagtgaga aatgggaatg tcactaccaaccataagtaa
62821 taaacaatag attatcatta actttgctcc tagagaaaga caagtttatttagaggtgag
62881 gcgagtagaa tttttttaag ggaacttctg ggtaatttaa caccatgatccttctcgaat
62941 gccttacaac gtaaaaatgt agttctcctt tttcttttct tttctttttttttttttttt
63001 ttgagacagg gtctcgcttc gttgcccagg ctggagtgca gtgacacaatcttggctcac
63061 tgcatcctcc gccgcctggg ttcaagtgat tctcctacgt cagcctcctgagtagctggg
63121 attacaggcg tgcactacca cgcctggcta atttttgaat ttttagtagagatgaggttt
63181 tgccatgttg gccaggctgg tcttaaactc ctgacctcaa gtgatctgcacacctcgacc
63241 tcccaaagtg ctgggattac aggtgtaagc caccatgcct ggccatttttcttgataaag
63301 gggtgtcatt ggggcttctc ttactcctgt cactcatcat gggtgccatgtctttttttt
63361 ttttttttga gatggagtct tgctctgtcg cccaggctgg agtgcagtggcgcgatcttg
63421 gctcactgca agctccacct cctgggttca cgccattctc cggccgcagcctcctgagta
63481 gctgggacca caggtgcctg ccaccacgcc ctgctaattt tttgtacttttagtagagac
63541 ggggtttcag cgtgttagcc aggatggtct caatctcctg acctcgtgatctgcccgcct
63601 cagcctccca aagtgctggg attacaggcg ggagccactgcgcctggcctgggtgccatg
63661 tcttaattga caaccacaat gaagagagga aggaaagagg aaagaataagacaatacaag
63721 aagaaaaggg aaggaaaagc caatgacaga cattaactgg attttcccacaaagagaggt
63781 catgaggatc aagagcatac agaagtttgc aaaataaaga gtttctctggcttggagttg
63841 accaaaataa gagaaaggtg aagcgagtat aatgtacgga gacttctcctgggagaagtt
63901 gtcagtggag aagttattgg gtcatatagt gatggtgtgc agataggacctggtggtgag
63961 ttgacgagga gccattgcca ttcagccatc aagaatcatg atgtgtgttgtgtaggaatg
64021 gagaggtgag tgtggagtgg atggggcgta gatggagaag caggaggattcgtcatgcac
64081 cctgaggctt gccagtattg atgtcagact tcctccgacc gtgttgccaccctggactgt
64141 ttgactttgg tagctatttt aaaacagcaa gaagagctgc ttgagaagaacctgggggag
64201 atttcacaac cagcagctgc atcgaatctc cctggatgtg tgcttttggaaacaatttac
64261 acaagggctg atttcaacat gcactaatat atacagttta gctggcattttatatggaaa
64321 ctttaataaa atggttctaa ttagtgctta atttacatag attagagagttctacaggcc
64381 cacacagtag ggcttgggga ttttatgtca tttgatggag atgccagtttgattcagata
64441 aagaaccaat tttagggaat actgctgaag tttgcccgac acaaatgaaggagttgtagc
64501 ttgcatttct tttacccact cttgttcagt ggcttgaact agctttctgtctcttccaca
64561 agatttagga caagatggat ttctgtgtca gcatgtagta ggagagctttgattttctag
64621 ttctgtcctg tgtggatctg tatgtagctc agattccccc acaatctaggtcagagaagc
64681 tgctagcctt ggtgcaaagt tttcaaaaag gcttctattc agagagatgaataaggaaaa
64741 actcacaccc tacgtgcgaa ggttgcttaa tgagaggtgt gagatggagctcagttgcca
64801 cttatctctg tagttgggta ccgttgtgca gtctgtgcac tgcccagccatttgcagtga
64861 ccccaaagag gatcatctgg tcatcttgcg gggagagact gtgagttcctgccatgtcac
64921 ttggtataac atgagaaaac tcaaaactct aggcagatct ttgcacctgccctacttttc
64981 tacctgctct cacaatcttc ttgagggtga ccagagtcca agtaactaagtgtaattcaa
65041 tgtggtgaat gatatgattg ctacacagga gtatctatta aggctttcaaaatgtaaaga
65101 ggaagtgact cattcttcct ggtggtggtg gttgcatcaa ttggtgtagtctattgcctc
65161 tctcccatca acaagggaca tttggcaaag tctggagtgt gtcaactgtggggtggtggt
65221 actaccggca tctagtggat agaggtcagg gatgctgctg aacattttacaatgcccagg
65281 acagccctcc cacaataaat tatctggccc aaaatatcag tagtgctgccattgagaaat
65341 ctggttatgt aacagataac tttttttttt tttttgacat ggagtttcactcttgttgcc
65401 caggctggag tgcaatggct tgatctcgac tcactgcaac ctctgcctcctgggttcaag
65461 tgattctcct gcctcagcct cctgagtagc tgggattaca ggcatgcgccaccacgccca
65521 gctaattttg tatttttaat agagacgagg ttttaccatg ttggccgggctggtcttgaa
65581 ctcctgacct cagatgatcc acccacctcg gtctcccaaa gtgctgggattacaggcatg
65641 agccactgtg cccagccaac agataacttt ttaaattctc agctgtttaacccaacaaat
65701 aattattttc ttcctcaagc tgtatgtcca gcatgggttg gcaacatagccctgtttttc
65761 ctagtccctt caagaagtct attgatggaa gatgcatttt tatgtgggcttctaccacca
65821 ctatgagagg gggaaggaaa tttgttggat tgtaccctga attttaaaaagcttctgccc
65881 agaattgaca tatattcttt ccaattgcat tttattggcc acaatccatcatatgaccat
65941 gcctgaattc agagggagta ggtggagaat acatttttaa tttttaattttttttttttt
66001 tttgagacag agcctcactg tcttgcccag gctggagtgc agtggcgccatctcggctca
66061 ctgcaacctt tgcttcccag gtttaagtga ttctcctgcc tcagcctcacaaatagccgg
66121 aattacaggc atgcaccccc atgcctggct aaggtttttc atatttttagtagaaatggg
66181 gtgtcaccat gttggccagg ctggtctcaa actcctggcc tcaagtgacccatcctcctc
66241 agccttccaa agtgctggga ttacaggtgt gagccattgt gcccagagagagtgcatttt
66301 tgtcttgtac ccagaaagag gagagagtga gaataatcat gaactaccctaatgactatc
66361 atgctgatgg taatggtggt tgtaggatgg tgtgagaatt taaagacggcttcactcctg
66421 tcactttgct tacttactgc tgtataacaa actgccccaa acttcagggatgaagctaac
66481 aaaaaaatca tttaatttgc tcatgaagtt gcaatttgga tagggctgtgtagaacagct
66541 cctctctata ccatggggca tcagttagga cagctcaaaa cctgggagtaactcaaaggc
66601 tgggggctat aatcatctga atgcttgctc actcctgtgc tctcatgtcaggcagtggat
66661 gctggctgta gacagagacc tcagctgtgg ctgtcagctt gaccacctactcccagcctc
66721 tacatgtggc tgtttggctc ccttacagta tggtggctgg gttccaaggcagaaagtaaa
66781 tgctgccagt ttcttaaagt ctgtctgcaa attggcacag cattctttctaccatattct
66841 attcatcaag gagttgtaga ggccaatttt aaggggaaga aaaatagaccctatgtttca
66901 atagcaggaa ggtcaaagaa tgtggaggcc ccagaaaact gcttcccaggtaagtgacag
66961 gatagaaaaa caagattttt tttttttttt ttgagacagg gttttgctcttgttgcccag
67021 gctggagtgc aatggcgtga tctcggctca ccacgacctc tgcctcctgggttcaagtga
67081 ttctcctgcc tcagcctccc gagtagctgg gattacaggc atgcgccacccagttaattt
67141 tgtactttta gtagagacag ggtttctcca tgttggtcag gctggtcttgaactcccaac
67201 ctcaggtgat ccgcctgcct tggcttccca aagtgctggg attacaggtgtgagccacca
67261 tgccaggcca gaaaaacaag acttctttag gtggagtttg gggaatgagctttctggaca
67321 agtaaacggc atgcatcaag gcacagaaac atcagagctg catttgaataaattctccta
67381 gctggtctta cctcctagct acttacttct actgttgaca tcaaccttataaacttgcta
67441 gaggctcagt gtggggaaac aaacaaacaa agcctcatga aacgttttgatccaattaga
67501 aaatgtctat taaatacatt gtgtttcaca aatgtgaact attaatacaatctgggtttg
67561 ttccgattta attgtctaaa attatacata attcatcttg ccaacaaatgaaattattga
67621 aaaattaaaa atatcaccac caattttttc tattaaatgt atatttttgtaatgatagct
67681 taagtttcat ctcagtttga gatttagtac actgtggcat tcactctggttggggttcat
67741 ttggctctga gcttcaaggt tcaatttaga cttcaaagca tgtcggacttgacctgaggc
67801 acgtttttaa caatcaggtg cagtttgtaa ggttatgggt tgaggaatagcataaatggg
67861 ccatcctttt tctgattttg agaagagaat gactactaat acccaggtgtgttcttgtct
67921 ttcttgagtc aattctaaca gcattggctg tgggttataa aaccataaaattttacagcc
67981 aaaaacaact ttaaaggtcg tttagatgga acttcttcat tttgcagatgaggaaactga
68041 gaatcagaga caaagtgacc tcagggcatt acaacttact attactatattgaaagagga
68101 agggaagctg gtgcaagttg agggacccac tgatgaactg cagggtatccaatgttgccc
68161 ctgtgtttgg gctgagggag aagcagcttc ttagcttctg ctatgctgacttatcttgtg
68221 atctctgtcc cagcccttgg ctgcctctcc tccttgtccc caggcctgcaccattccatc
68281 tgcctcctga ttattcactg acagctgcct tttccctcac cctttgttctcagtttttaa
68341 aaatccaatg gggagaagct tggattcaaa tgatagcatt ttcagctcatgaaaaattct
68401 ataacaagtg tatttgaccg tttgatctct ggcttctccc acacacttgccctttatact
68461 ctgacagcca taagcttcat ttccttgaag cagattgcaa tttcaatggaaaggaaataa
68521 ttgtgtagct ttcaagctga gttcagttct aaaaaggact gagcaaagctcaatcctggg
68581 ctattgtaga atcttagtca ctgaatcagg cagtgaaaga gctctctccaagcttcatgg
68641 ttatgatctt gaaaaacacc agagctaggt tcaaattcca gccataccatttcctaactg
68701 tgtgattttg gcaaatcaca caaatactta aaattctttc gactcggtttcctcttctgt
68761 aaaatgggaa cactaattaa tgctcacctc aaaaggttgt tcattcattcaacacatatt
68821 cgttgggtgc ctcctgtgtg tcaaactgtt tcagtccagt gaggaagatggacatgaatc
68881 caagagtcac caaaaaaatg taaagtggca cctgtgatga gtcacaaaggggaggtatat
68941 gagaaagtgt gtgacagtat ctaacaggtg agggcattat ataatttattgttgcaaaca
69001 ggacattttt gagcatgtaa gagggtgtgt taattgtcct ggaacaacaggcataaatca
69061 ggactttctg ggcaaactca ggccctaccc cactcttacc tacccttagtataagaggga
69121 aggttgggaa aggctttcct ggggaaggga agaagaaact gagatccgcggaataagtga
69181 ggattcctag gcaaaaagag gaagacagag tggtttaggc caagagagcaaacagtggtg
69241 caagactcta aggcaggaca aagcatggag cctgcagaga acagacagaaggtcagtgtg
69301 atgaagatgg gaggggtgcg tggctttaaa cacaggcccc ttgcttgttggtttgccctg
69361 taggtgttaa gaaatgaggc tatatcaagg tgaattttaa gtagaggtggcacctctact
69421 taagaccaga cttgcagctt taaacatcag tctggctgca aggcagaatggattagcatt
69481 gagtagtagt tctggccttg gctttccaga ggaaacttct aaacaatatcaaagccttgg
69541 tgtcacccac agagatcctg atttaattag tttaggttgg ctcccagtaggttataaagt
69601 gtgtcaggat tgagattcac tgtagaagga agtgtgaata tggagaagaataattacaag
69661 gctattgcag tagcccgggt aagaagtgat ggaataggtt catggcagtgggtttctgaa
69721 gcagtggttc tcaaactgta gtggatttga gtatcacctg gaagtcttatttatttatta
69781 gagatggtct cacactgttg cgtaggctag agtgcagtgg tataatcatagctcactgca
69841 accttgatca gccttcatct cctaggctca agcaatcctg ccacttcagcttcctgagta
69901 gctgggacta caggcatgga ccaccatggc tatttgtttg tttgtttttaatagagacag
69961 ggtctcactc tgttgcccag gctggtctca aattcctggg ctaaagcaagcctctctcct
70021 tggcctccca aagtgctggg attatagcca ctgcaccttg gcacggaaaccttgttaaaa
70081 tgcagatatc tgggtatcat tgatttagta ggtcgtggat ggggcctgagaatttgcatt
70141 tctgacaaat tacctggagg cgctagttgc tagtttagag atcacacttagcatctagtg
70201 ggtagtggtc agggatgctg gtgaatatca tacaatacac agaacagcccttttgctgat
70261 cactgatcga gcaaaaaaac catctgatgt ggtagataac atcaacaggatttgatcagc
70321 agggtaaagg acaactccag gactcttaca gttttctgaa tttcacaactaaatgacgag
70381 tttcactatt cattgacatt caggagacag ccctacagac ctgagaagatggtgaagtca
70441 aagctacaca tatatttgag ggttaccttt gaaacagcta agaggatacatcaagcagga
70501 acatatatgt ggaacctgga agggaagatc attacagata taaacttggggatcattaaa
70561 gccaggaact tatcaatggc atcagtcagt tctcttttct tttactcttatcattggtgt
70621 caaagctctg gcctcttttt gttggttcca ctcaggtgcc gtgatcctccagcctcagca
70681 ccttgctgtg agctctcctt gggaggctgc ctctccctcc tccttcagaatttaccccct
70741 acttctcctt tgggtcccac ctctcaggct tggtcatgtg tggcattagcaagcaggtgt
70801 gcgtgtttcc ttctgaagca caaatcaaag ccatggttat gtatctgtgggattatttgc
70861 taaatggcca cctctcctgc tagattctaa gttgcctgca gtgactggagaacatcccta
70921 ggtatcagat gctcaatgtc ttacacttat ggaaccgtca aagacagctgttaaatgtcc
70981 aatgggtcag ttagggagat ggtggttgtt aaaactgtga tgagttctcaggaagaggga
71041 gaagcagtta cctttgtgaa gcagttgttg gtatttactt agtaatgagattaaatttcc
71101 taggacagtg ggtgtgtgaa ccagcaatag cgccatctgc tggaagtaagtgatacaaca
71161 actattatct tgactaggct cagggctgtt aaaacagtat tgctctgggagaaaagaatc
71221 atttttttta aggttaaaaa tgtgagtaaa attctttaga gtgaagatagaatttctttt
71281 gaaatggttg gaaaaattgg ataattattg aaaatagtgt tcagttttcaaagaggagag
71341 aaaccttcaa gtcactgtaa ttaagagaag ttttattgaa agaacacatggaataaggaa
71401 gttagatatc tccacccaaa accagcattt cagaaaacag aaacaggcaaaaatctggcg
71461 gagtgtggtg gctcatgcct gcaatcccag ccctttggga ggccatggtggaaggatcgc
71521 ttgaagccag gagtttaaga atagcctggg caacatagta agatccccattttctttttt
71581 cttttctttt cttttctttt tttcttttct tttctgagac agagtgttgctccttttgcc
71641 caggctggag cgcaatggca tgatctcagc tcaccacaac ctcccgggttcaagaaattc
71701 tcctgccttg gcctcctgag tagctgggat tacaggcatg caccaccacacctggctaat
71761 ttcgtatttt tagtagagac gtggtttctc catgttggtc aggctggtcttgaacgcccg
71821 atctcaggtg atctgcccac ctcggcctcc caaagtgctg ggattacaggcatgagcccc
71881 cgtgcccagc cccaagaccc ccatttctat tttaaaaaaa aaaaagaagaagaagaagga
71941 aaagaaaaga aaaatggaaa caggcgaaaa cctaggcttc tcaaagactgaagggtattt
72001 tggaactgac tggatattgc tcatctctgg ctggttgtgt tgcagcctcgttggtggcaa
72061 gtgcagaccc tcagtcagtg acctcctttg ttgctcttcc atcaaagggcccccttctcc
72121 tgcccaggca tggtgttact aatatggcga tggtaggggc aggggctgcatctatgacgg
72181 ggagaggtat gagagtatac tcatcattct gctgttgtct ttgttagtttgtttctaatt
72241 tctattgttg gggagaaaga taaattcttc cctaacctct tgggatcttcacctgggtct
72301 aagaattaaa tcactgtaag acaggttaac aggagaaaaa tatatgagttttattgattt
72361 ttacatgtac gcggagaccc tcatgagaca gcagaagacc tgaagaaatggacaaagcag
72421 aaagctctaa taccttttag acagagaaac cataaattca tgaagagctgacaagacaaa
72481 ggggtttggg ccagtggcag taaattgtgg gaattcacta gggaggtgtaaagatagagg
72541 aagataaggg atagtttaga aagtttattt gtacagctcc attgcagcatcaactcccag
72601 tcaatggtga taagagttat tttcttattc tggtacaggg agggcaactttcttaaataa
72661 atctttttgg cttacgacag gtagaagagg gcagatcaca tagccctttccggcatctgc
72721 tgtttctcag gtgactttag ctcaaaataa tcaacatgcc acatcagcaaattttggggt
72781 gacatggcct gtttcgctat gataatggga aagaaatcag actttttaactttgaattag
72841 aaaacacaaa ctttgactat gtcccacaat ttatgtgact gatttcatattctatcacat
72901 ctattttata ttctctcata ttctcctcat gaattttccc ctagaatgttgggggaattt
72961 tgaaatgact tggggggcat gctacaattc gaaaaggaga gagacatactctccaattct
73021 ctccctgcct gcctcacaat gtgcagctct cctctgcttc ttcttcttcttttttttttt
73081 tttgagacag cgtctcactc tgtcacccag gcttgagtgc agtggcgcaatcttggctca
73141 ctgcaagctc cgcctcccag gttcaagtga ttcttctgcc tcagccttccgagtaggtgg
73201 tactagaggt gtgtgccacc acgcccagct aatttttgta tttttagtagagacggggtt
73261 tctttatgtt gaccaggcta gtctcgaact cctgacctca ggtgatctgcccacctcagc
73321 ctcccaaaat gctggaatta caggtgtgag ccaacatgcc tggcctcctctgcttctgat
73381 tcaactgctg ctaccgatag acttactgaa ggatttgaag ccaaatggtattaattttgg
73441 tcagttactt ccctgtatct ggtgtcctca ctagacagaa cttctgtgtatggctacttc
73501 atagaccccg accagcctac atattgtttg ctctaaggtc tagtgccctctcttatttca
73561 ctaagataca gccactgttg gtgggggagt cacataacat ggaacataatcactgtatca
73621 gttcaggtgc tcttgattca agtggattta attatgaggg aatttattccttacataatt
73681 actaagtcta gcattagagt ggcctgcaga tgagggttga tccagtggctcagtgatggc
73741 cagaacgctg tttacttttt ccattctgct atctatgggg ttggcttcatcctgaggttg
73801 ttttcctttc tgtcacaggt tttacatcaa tggggtaaac tagtttacattgtggtaaca
73861 agcaactctc aacttttttt tttttttttt tttttagact gaatcttgctctgttgccca
73921 ggctggagtg cagtggtaca gtcttggctc actgcaactt ccgcctcctgggctcaagtg
73981 attctcctgc ttgagcttcc tgagtagctg ggattacagg catgcaccaccacgctggct
74041 aattttcgta tttttagtag agatggggtt tctttttttt ttttttttctttttgagaca
74101 gaatcttgct ctgtcgccca ggctggagtg cagtggcgtg atctcggctcactgcaacct
74161 ctgcctcctg ggttcaagcg attcttccgc ctcagcctcc caagtagctgggactacagg
74221 cgcatgccac cacgcccggc taatttttgt atttttagta aagacagggtttcaccatat
74281 tgaccaggct ggtcttgaac tcctgacctc gtgatttgcc cgcctcagcctcccaaagtg
74341 ctgggattac aggcgtgagc caccgcgccc agccaactct caactctagtagcttaagac
74401 aacaaagatt tatttcttgc tcttactgtc tgcccatctg tatcaccttctctgcaggac
74461 ccagtttaat ggagcacaca cagaaaaagg tgctggtcac tagggccaagggaacaatgg
74521 ctctggaagg tttttcttga acaattcagt gttccagtct tggagcaatacatcttattt
74581 ctactgttaa atccatggcc agaactaatc atgttgtccc actcaccacaaagccatatg
74641 cagccccacc atgtgctcag gaaagaggaa tgggaagcat ttgatgaacagaaataatga
74701 cttcaacaat tgggactatc agttcacagt ttcaattgta aaaaaaaaaaaaaaaaaaaa
74761 agacagaaat agaaaaagaa caattgaaag tacttgcttt ctcatccacgaaaaaagttg
74821 gtcaaagcct cttagtgtaa gtctatagca gatgatgcct gataaggaattgtacatacc
74881 gttcttcgtg aaaaccaaga gtaccatgta tgtaacatag ttgctttgggcttcttatag
74941 cagttaagag tgtatcagca ggcctccatg gtatttgaat gttaaaagctttcattcccc
75001 ctggaagaaa acacatagct aactaaagaa agaaaaaaga agggaaaaagaacaaagaaa
75061 aagaaccact agagtctctg aaaagagctt atgagatacc tgactgtctgcgccttctaa
75121 gtatgtacca tgaaacctta gattcctacc tcattttgtg atggtgtagaaggcacattg
75181 gccaccagca acccttgtaa atatttgcgg atttgaattt cacaaattgaaacccagact
75241 gctgagggct ttgctgctaa cgtcaaagag ctggggcaac taccacaaaaccacatgtgg
75301 gagacttttt agatgaggag ataggaaatt cctaataaga aaagtttttttgtaaaatac
75361 tttctaatgc tggctcttta gagaagcaca ttttacatgt gcaatggtgcaaagtcctag
75421 cactaagatt tcttcactca cagaaagaaa gaatgatgca ggtgctgttcacatgcggcc
75481 ggaaccatgc ccttgccaag caggtcagcg gggcacaggg actgcgctcctcatgatagt
75541 gcagattggc tcggaagtac tcaattctgt ggagtcacag cgccctctgacagatttcag
75601 tttctggaaa aggaagggcc cccttcaggg tacctgctgt tcaccttccattagattaag
75661 gttgaagagc gagtggccat ttgtaggtac tggtatgaga tgttcctagctacccgcatg
75721 tcagccccgg gaaacggcaa catttcccac ccttcttacc ctgggtcctgagtaggaata
75781 aaagttagtg attcttaggg gcatattgag agctggcaat gatacctctcacaaatccat
75841 cccccagaga taaggggtcc cccatgcctt tgatgtattt gggagctgtgctgtatgtgt
75901 tctctttggc tccccagtgg agaataataa caataacaac cgcgtactaatacaacccag
75961 atgtcagcac agaccctctg ttctctgtct tccctgagat atctgtatcttctcagggat
76021 tactgtcggt tcaggcctgg ctcctgcttt cagcttgtgg gaaaactcactccatcttca
76081 ttccataacc tcacatctcc tatgccagtt cccttctctg tgctccatgctgaaccaaat
76141 gccacactca tcccctttgc tttgaattat atgaaaaaaa gaaaaaaccctcatggggac
76201 tttatgtgta acagtcttca ctgcacattt gataacacag atgggggtttatatcctagc
76261 agagcagata ttgtcaatgg aaaatggaaa caaaacaaaa cacaaaagacaatcttcagc
76321 catcactatg tagcttggct atcatctttt gctttctcct ttacttctggagtcccccca
76381 cataccctca gaaatggaga tagactctac atcaatctct gctctgggaaatctactcac
76441 atatccaaag gcaaactaac aagctcttgc tccgacaacc catcgacttggggtctcatc
76501 cctccctgcc taccagtctc tgtgactgaa aggggcccat acagagacttattttcccag
76561 gaacgtgaat gatatccttc tcctgttcct tgaccttggg aggcagatttgattatggtc
76621 agctttgatt caaagtaagt tttttttttt ttctccctta ggagaatgttgtgaggtgct
76681 gattgttctc tgcttcataa tcgtatcact tattactgat aatctttttctgcccccaga
76741 ggttgctgaa gaatgtagca tatacagtgg acacagagcc ctgataatacaattactaaa
76801 ttctccaagg ttgagggcct ggtcttaggt catgagatta ctgatccttgccttctgcct
76861 gctaggaagg cccaactaat ttcacagtct ttatcagtga accatagtaaagggggacca
76921 gaagagaaaa aggttatgtc ttttgggaaa atgccaaaat catattgtgaaaatccttcc
76981 tactgttctt ctcatgggag ggggaggact ttggacttgt ttctctccttttcctgtaca
77041 tttggggatg tcagaaccgt ctgtttcctc atctacacgt ggttagatgccgacaacaat
77101 ctcttctctt aaaattgctt actattagac cagcagagtg tttggtattaattgagcaag
77161 gaggaatttg taggaaaggc ttggcttaac taggagaggg aatgccagggagaaatctgt
77221 atttcccact attttttttt ctttttttga ggcacagttt cactctgtcgcccaggctgg
77281 agtacagtgg tgcaatctca gctcactgca acctccgcct cctgggttcaagcgattctc
77341 atgcctcagt ctcccgagta gctgggatta caggcgtgtg ccagcacacccagctaattt
77401 ttgtattatt agtatagatg gggttttatc atgttggcca ggccggtctcaaactcctgg
77461 cctcaggtga tctgcccacc ttggcttccc aaagtgctgg gattacaggcatgaaccacc
77521 acacctggcc atttcccact attttgttga taaagacatt tggatttccctgcattaggc
77581 agatgtggaa gaagatggaa gcgatgaaaa ccttcttgcc aaaatctcccaaaagacctg
77641 gccagtgggt gagcagatct cagttacaaa aagcctatag gttgaattttctaagaaaag
77701 gcctggggag gaggtaccag gagtccaaat tgaagttcga ttttcattatcacagatttt
77761 catatctctc tatctccctt tttttgtttt tggtgagaca gagttcaagaccagcctggt
77821 caacatggtg aaaccccgtc tttactaaaa atacaaaaaa ttagccagccgtagaggcgg
77881 gtgcctgtca tcccagctac tcgggaggct gaggcaggaa agtcacttgaacccaggaga
77941 tggaggttgc agtgagccga gatcatgcca ttgcactcca gcctgggcgacaagagccaa
78001 actccatttc aaaaaaaaaa agaaagaaaa agaaaaaaga aaaaaagaaaatgcactttt
78061 tgctgtcagt aaaagttaag caaaagtctt gctgagagac tgatatttaaataactatta
78121 taatgcaatg taaaattact gcaagagata tgaacacagt gctcaggaagcttagaggaa
78181 ggagaaacca agtccttagt gatggaaggt gggctgtcaa ggaaggctttgtggaggttg
78241 tgtaattgta ggatgagggc catgtagtag gtcgacgggg ccctcgtgtgccaggtggaa
78301 ggaagccatt taagtctttt aagctgagtg gtggcatgat tacaagtgcactttagaaaa
78361 atctctatgg cagcaatgtg gaggatgaag taacaaaaat atacactttggttcattttg
78421 ttctaaatgg caactttacc tttaactgtg tacagagctt actgactatactcaagcaac
78481 aaaatgcaca cttggaaatc ctgtgtcacg tgcctatact agctttgtcgctgattcagc
78541 atatacacat cctccagtgt gacaggattg tgtatggaaa caggtaagactggtgaatac
78601 taggctgtgt tcaagtgtag agtctcatga ttatcaccaa tactgtgggctctccctctt
78661 ttagatgagt ttttctacca tatctttggc tttacaaaat atattaacacagtttcataa
78721 tagatctctt ggaatatggt cgtttggtgt taagcattct atctggcaaaatgaaaaata
78781 agatggtaag agttatccta caaaaatcct aatgttctca agctactgctgaaattcttt
78841 ttctagtaat ttacaaaaaa gtccccattt tcttgtagaa ataagccaattaaaaaaaga
78901 aaaaaattaa aataaaaaat taaagttctt aatgataaat tatattaaaatttatttcct
78961 gttttaccct atatcctatg agcgtggttc tcaaacttcg ttcagtgcataccagaatca
79021 tcatgtgcgc ttgttaaaca gaggtctggg ttccaccccc agagcttctgattcacttca
79081 tggaatctga gaactggcat ttctgacaag ttcccagggg atgctgaggctgctggtcca
79141 gggaccacac actgagaaat attgttctga aataataaca gctaatttttgttaggcagt
79201 ttctgtgttc caaatacagg ttgaatatcc cttatccaaa atgcttggggcaagctgggt
79261 gcagaggctt attcctgtaa tgtcagcact ctgggaggct gaggcaggaggattgcttga
79321 gaccaggaga ttaggaccaa cctaggcaac atagcaagac actgtttctacacacacaca
79381 cacacacaca cacagacaca cacacacaca cacacacaca aattgccaggcatggtggca
79441 tatccctata gtcccagcta cttgggaggc tgagggagga ggatcacttgaaacaaggag
79501 tttgagacta tcctgggcca catagtgaga ccctgtctct acaaaaaatatttgaaaaat
79561 tggccaggtg cggtggctca tgcctatagt cccagcactt tgggaggctgaggcaggtgg
79621 atcatttgaa gtcaggagtt caagaccagc ctggccaaca tggtgaaaccccgtctctac
79681 taaaaacaca aaaattagct gggcagtagt ggtgggcgct tgtaatcccagctactcagg
79741 aggctgaggc cagagaatcg cttgaaccca agaggtggag gttgtagtgagctgagatcg
79801 tgctcctgca ctccagtctg ggtgacagag tgagaccctg tctcgaacaaaacaaaacaa
79861 aacaaaacca aaaaaaccaa aacaaaaaac atattagctt ggcatggtggtgcattcctg
79921 tagtttcata tacttgggag gctgaggcag aagaattgct cacgcctgggccttcaaggt
79981 tagaatgagc tgtgatctca ctactgcact ccaatgtggg tcacagagcaggactcaaat
80041 gaaaacaaaa ccaaaaccaa aattcttggg accagaagta tttcagatttcagattattt
80101 tggattttga aatattggca tgtatctaat gagacatctc agggatgggacccaagccta
80161 aacacaaaat tcatttattt ttcatataca ccttgtatac atagcctgaaggtaatttta
80221 tataatattt taaataattt tgtgcacctg tcacgtgagg tcaggtgtggaattttctac
80281 tgtggtgtca agtcaatgct caaaaaattg cagattttgg agaatttcagatttcagatg
80341 tttggattaa atgtgcttag cctggacctt acttgttgta gctcgtttaatcctcatggc
80401 aatgctagga cacaggtggt tttagtataa tattattaca aatgaagagcctgagacttg
80461 agaaagtaag acaacacact ccaggtcact cagccaatta gtggtgagcaagaattgaac
80521 ccagatttga tatgcgaatg acttgctgtg attctcctat tggtgatttttttttttttt
80581 tttttttttt ttgagacagg gtcttgctct gtcacccagg ctggagtgcagtggcatgat
80641 ctcagctcac tgcagcctct gcctcccagg ttcaagcgat tctcctgcctcagcctcctg
80701 agcaactggg actacaggca tgtgctacca tgcttggcta atttttgtatttttagtaga
80761 gatggggttt caccatgttg gccatgtgga tctcgagctc ctgacctcaagtgatccatc
80821 cgcctcggcc tcccaaaatg ttgggattat aggcgtgagc cactgcacccggccccttat
80881 tggtgtattt ttatttccca agtatgacac ctgttcagag actttggaaccctgagaaca
80941 ttttgttggt gtgttttgtg actaatattg cctttttctg agatgaatgctgttctttga
81001 aaaaacattt gtatttttag atagaaatgt acttcatccc cagtgaatatttctgacttt
81061 agagaaattg ccaaacctgc tgactcataa caaaaataaa gagcatctactattcagttt
81121 atggctttta gttttgggag gtggtaggag gaaggataga ttaccacccactatagatca
81181 ttttattttc attttatttt aatgccattt accagtattg tgtatatggaggtggtcttg
81241 agagctttgt ggagattatt ttttcaatag tacagatggc tctgataaatatttaaggca
81301 tcttgggaaa caagaatacc atcctgactc aggagaaatt ggtcacgtaaatcactttgt
81361 ttcaagtgct ttggcctctg agcatctcaa atggacacat acttcattggcttattaact
81421 cattgccgga gtcactgaag gcccaaacta caacttcatg cctgaccacacaccaaggct
81481 tttttattgc ttagttttct ggctctttgc ctattctgct ctccctacccataaccatgt
81541 gagtatcatg tccagcaaac taacttactc cttctctctc cccactacacacacacacac
81601 acacacacac acacacacac accacactcc acacgcacac atacacagagcatttttcat
81661 gggtatgttg tcagacagat ttctctgttc tgaaggctca tctccttagagaaccttacc
81721 gtgtcaatgt tgcatttagt ttagtttagt gttgttgttg ttgttgttgttgttgctgtt
81781 tttaaatctt gctctgttgc ccacagtggc gcgatttcag ctcactgcaacctctgcctt
81841 ttgggttcaa gcaattctcc tgccgcagcc tgctgagtag ctgggattacaggcccccgc
81901 caccatgtcc agctagtttt tgtattttta gtagagacgg ggtttcaccatgttggctgg
81961 tcaagtcttg acttcctgac ctcgtgatcc acctggcttg gcttcccaaagtgttgggat
82021 tacaggtgtg agccactgcg accggctgtt tttttttttt ttttttttttttttttcttt
82081 tttgagacgg aatttcgctc ttgttgccca ggctggagtg caatggtacaatcttggctc
82141 attgcaactt ctgcctcctg ggttcaagca attctcctgc ttcagcctcccaggtagctg
82201 agattgcagg tgcccaccac catgcctggc taatttttgt attttagtagagatgggatt
82261 tcaccatgtt ggtgttgtat ttagttttaa cactgttatc ttctcagattgtaatgagag
82321 aacaggctat catcacttgg tgataaaatt tcctgtaatt ataatctcattctcaaagat
82381 aaaacattga tacctaatgt gcttttaact ttaatgccaa tttatcacaatggaagacat
82441 ttcaaataaa tactgttttt ttgttcataa ggtcttaaaa atcttgaatataactgcaaa
82501 aaagcattac atgttaaaag aaatcacaaa attagttaag aaaggagccaaactgaaaga
82561 agattatatt tctatgccct tgaatcttta caaaatttag taaaaactattaatatagaa
82621 ttatttacaa gagacttctc tatttaccag cccaatatct tcacatttctacaatctaag
82681 gggaggtgat tgtggccaga aaagtttctg ggctctggta ttgcagttttcctgcactta
82741 ccaccatccg gcatgttata tattttactt atttttcttg cttattgctgtctctttcca
82801 caagttccat gagcagagac agtttatctg tgttttttac ggctattctcaatgtctgta
82861 acagtgtcta acgtactata gtcattaaag aaatgctggt tgggtgaattcagaaataaa
82921 ttagtaaata ggtgaagcat gttggtttaa tattcatcat cagaacttaaaaacagttta
82981 aagaacctca actgagtttt gtacaataag tagtgacaag gtgggacagaggtaatttct
83041 ttgtatctct gaggctttcc atttcatgag gaacatagaa taatatgtgtttccaaatgc
83101 agtgttcaat atctgaagag tatatatcat cagtatagaa aatagacaacacatgttaaa
83161 gggaatgtaa aaattctaga tgatttttaa ggtatgtatg gtttaatcaattgtttatat
83221 gctattctct tctcttaaaa tgaaataatg cgaatgaaaa aataaaccttacaggtagtt
83281 tctgggaaat tcagacaaca aaattgtcta acatacgcca aaaacaatatagcatttaat
83341 gatgacatgg attccgaaag acaaatcact gctcatcata ttacaaggaatccaaacaac
83401 tgaggggtta tcatttatct atagttgcat aacaaattac cctaaaatttagcagcttaa
83461 aacaacaatt tattatttca taaatttctg gggatgagga atccagaagcagattcactg
83521 ggtggttctg gctcaaagta tcttatttgt ttgctagggc tgctgtcacagaacacaaca
83581 gcacaggtgc cttaaataac agaaacatgc attctggagg ccagaagtccaagaccaagg
83641 tttcctctga ggtctccgtc cttggattgc agatgcttgt cctcttgctccctcttcaca
83701 tggttgtccc tctgtgcaca tgcacttctg tgtctctttt tgagtgaaaatttataagca
83761 ttccagtcag attaattttt tttttttttt tttgagatgg agtctcactctgacacccag
83821 gctggagtgc agtggtgcaa tcttggctca ctgcagcctc cacctccctggctcaagttc
83881 ttctcctgcc tcagcctccc aagtagctgg gattacaggc atacaccaccacgcctggct
83941 aatttttgta tttttagtag agacgtggtt ttgtcatgtt gcccaggctggtctcgaact
84001 cctggcctca agttatccac ctgccttgtc ctcccaaaat gttgggattacaggtgtaag
84061 ccattgcacc ctgccccagt cagataaaat tttaatctca ctttaacttaatcacttctt
84121 tgaaggccct gtctccaaat atagtcacat gaattagggc caagctgtatggcttcattt
84181 aaccttaatt acttctttag aggctctatc tgcaaatgcc tccacattctgaggtggtgg
84241 gggggttagg atgtcaacat atgaatttga gggggcacaa tttagcccatagacacctgt
84301 catgaggttg tagtcagctg tcagttgggg ctgcaatctc atctgatggattaactgggg
84361 aaagatgggc ttcccagctc actggtgtag ttgttggcag gcctcagtttcttctcgctg
84421 gagacttcag ttcttgccat cggcttctcc acaggttgtc cagattacctaatgacatag
84481 cagctggctt ccccaaaagc atggaatggg ggttggggat gggataagagagagagaatc
84541 caagacagaa tgcacagtct tcttataact taggtttaga aataatatatcagtacctct
84601 gccacattct gttggtcaca cacactaacc ctggtaaaac atgggagtgaaccatacagg
84661 gggaactggg gtcattggtg gtcatctttg aggctggcta tggtaattaggtaaaaataa
84721 aaattcagtc tgcagaaacg tatgtactta tgttacttaa aatattttaaccaattagtg
84781 aaaaatgact ttgaagtatt tttagctgct ataataattg agtaggaattattttttctt
84841 ggattgagtt atatttacta taaaaatact tacttttttt gtcaaacacatttataagtg
84901 ctgcaaatat tagtgaccaa tggtctattg ctctaaataa aaagcaccaggagttagtat
84961 agtagttgac tccagcctct ggtgctagac tgcctgggtt tgaatatttacttttgcact
85021 tacaacttgt aacaacttga acaatttatt caatctctct gttccctagttttctcatat
85081 gtcaaatggg agaaacaaat aacatctgct tcatatggct gttatgaaggctaagtaggt
85141 ttatatatat gtatgtatgt atgtatgtat gtgtgtgtgt gcatatatatatatatatat
85201 atagagagag agagagagag agagagaaag agaacttaga atagggcctggcacagagaa
85261 tatgataaaa gaatattatt tgtttcctct ttttatcatc cagaacatggtgtaatgccc
85321 aatacattgt agatactcaa taaatgtttt tgtatgatcc ctaaacattgtctgtaagga
85381 atttacaatg gagtttacag taaaaggtgg tacatggtag gtaccatggaagcattacaa
85441 acagatgacc atgtgaatct gaaagaagca cagattgatt tcttcgtcataaaacatggt
85501 tgtatttgag ctaaagctta gaactaatga agattattgc caggcgtggtggctcacgcc
85561 tgtaatccca gcactttggg aggccgaggt gggaggatca caaggtcagaagatcgagac
85621 catcctggct aacatggtga aaccccgtct ctactaaaaa tacaaaaaattagctgggtg
85681 tggtggcggg cgcctgtagt cccagctact caggaggctg aggcagaatggtgtgaaccc
85741 aggaggtgga gcttgcagtg agccgagatc gcgccactgc acttcagcctgggcgagaat
85801 gcaagagtct gcctcaaaaa aaaaaaaaaa aaaagagtat caatgtatcaaaatcattat
85861 tttaggctgg gcatggtggc tcacatgtgt aatcccagca ctttgggaggctgaggtgag
85921 agatcacttg agcccaggag ttcaaggcca gcctgggcaa aatggtgagaccctgtctct
85981 acaaagaaaa aaaaaagatt attattcccc aaataggaaa taacataagcaaacgtcccc
86041 tatttccccc acgatggagc tggagcatgg tgtatgagaa ggagagtcagagggagcaag
86101 aatgaagggg tcaggttggt accaggtaat gaaatcattt taacataagactacatgatt
86161 tggacttcat tgtgtggtca cttcggagca ttttagcaac aaaataatgtcttaggaaga
86221 ttaatctggt ccaattgtaa agtaaattga gattcaggct tcaggcttggcttgatccag
86281 gattcaaata aaatcaccaa gaatctgtat ttcagatctg ctttttttgtgtggctctgc
86341 ctgtggctcc ataagaagca cagaaaaaag agaaatggtc tgttaaacagaaaaagtgaa
86401 aaagcttcac tcccagaaaa tatcttcttg catctcatcg gcctgagttcactcatgttc
86461 gtattcttca acaaattatc atgtccagga tatgaaacgg ctgcttggatccaggcacac
86521 tgataacgct gataccacac ctagaaaaag aaatgaattt cattcaaattccattctact
86581 attttaaggt ttcatgtcta gatggctgga gattaagtgt tgcagtccaggcgtggtggc
86641 ccacgcctgt aatcccagca ctttgggagg ccgaggtgga cagctcacttgaggacagga
86701 gtttgagacc agcctggcca acatgatgaa accccatctc tactaaaaatacaaaaaata
86761 gccaggcttg gtggtgcgtg cctgtaattc cagctactcg ggaggctgaggcaggagaat
86821 cacttgaatc caggaagtgg aggttgcggt gagccaagat ggcactactgcagtccagtc
86881 tgggtgacag agacttcatc tcaaaaaaaa aaaaaaaaag taagttttgcaattaggaga
86941 catgcctata atgtttattt agtggtgata cgtatggttt agtcctttaattatagtgtg
87001 gtttaaatgc aaatttaaag taactcaaat acagctattt tttctcacatcatagggaga
87061 ctataaagtc cctcagtaat cattcttcaa atagatattt ttcttctttcatctactgcc
87121 ttcacgactg cagtcacttt ctccaacagt cttttctcca aataaaaacaaaaacaccac
87181 taccaccact accaaaaatc tcaagtacct gctatctctg atctttctcatctgctaata
87241 ttctcttcct cccttactcc cctcctcttt tcttcctttc ctccttccccatctctccat
87301 ctcacacctc cctctcttcc tacctccctt tctttcaacc ttttccccttctattcttcc
87361 ttccctcgct tcctccttcc cttccttcct tccttccttc cttccttccttccttccttc
87421 cttccttcct ttttgctatt aaaaattcct caaactggct gggtgtggtggctcatgcct
87481 gtaatcctag cactttggga tgccgaggtg ggtggatcac ttgaggtcaggagtttgata
87541 ccagcctggc caacatggtg aaaacccgtc tctactaaaa atacaaaaattagtagtgta
87601 tggtggcacc gcacctgtag tcccagctac tcagaagggt gaggtgggcgaatcacttga
87661 acccaggagg cagaggttgt agtgagccga gatcgttcca ctgcattccggcctgggtga
87721 cagagtgagt gagactgtct caaaataaca acaacaacaa aaacaaactggcaatgcagg
87781 acttccttga aagacagagg aaaggaaaag attaagagaa gttataccaaaactcttttt
87841 aataggtagg cagggaaaaa attgggaacc tttatacatc aataattttattctcataat
87901 acttggaaat catgactagc tgttgctctt cttcaacatc taactattatcatttccaca
87961 tctgattcaa gcacttcctt tttacatgtc tttttttttt ctttgcctgaaatattattt
88021 ccttccatca aattaacctt tctgcccacc tggcaaccct ctcttcttcaagccttactc
88081 atcaagaagc cttccctagc aacagggaag gctctgctac caatcccacctttatgctct
88141 ctggactacc actttgtctt gtacatttct attaaattgt aacttttcatttttgttaca
88201 catctattga ctctactgct cagtgaacta tttgagacca ggacaccattttgcatacct
88261 agcacaatac ctaccacata gtagacattt cataaatcct tattgattgaataaatcaat
88321 gatgaataac atttttataa atttcatttt gtatttgagt tgaagctccaagtattacac
88381 cctgttagag attttaaact tgatttttaa aatattggac tagagcttaaaagaagatta
88441 tattagtcag gggtctcaag agaaacagaa tcaataaagt atacatttattatataattc
88501 attataagaa attggctcac atgattgtgg aggctgacaa gtctcaatacctacagtcgg
88561 caagctagag acccaggaga acctatggtg tagtccaggc tcattccaaaggcctaagaa
88621 ccaagcgagc caatgatgta gttctagtgt gaaaacctgc aggctctagacacaggaaga
88681 agccaatgtt tcagttaaag tccaagggca ggaaacacca aggtcccagctcaaacatag
88741 tgagacagaa ggaattctct cttactcagc cttttgttct attcaggctttcaacagatt
88801 ggatgaggcc cacccacaat ctgctttacc cagtctactg atttagatgttaatctcatc
88861 cagaaacacc ctcacagaca cacctagaat aatgtttgac caaatgtctgggcaccctgt
88921 tacccagtca agtggatgca taaaattaaa caccataaag actaaagcctgtagatgaat
88981 atctggtaac acctcacaga ggagagacct aaagctgtga taacgtctctgaagccaaga
89041 gagaaaggct agaaaaagca agatctggga tatttcctta gaatccttgcctgaaggcca
89101 agaagatgag gaagttaatt ttctcatcca gagtggtggt atcgagctagaaaattgtga
89161 agatctttct agttctaaaa catctgttac ctccttacct tggggtttcaagactgggta
89221 aatggaaata ctaagataat tggatgatgt aagaagattt tggatgggaacaatatcttg
89281 ttatgcacca gttgtatgga aactacttat ttataagatt taaaattctacgtatattcc
89341 ttcaggaaat gttgtcggct ttctacaaga tgcagcttta attgtattattgggaaccat
89401 cattgattat taggttcttt ggagaaattt ctttccttca attagaagcacccatgaagg
89461 atatgaagaa gagttggtca aagaactata agaagatcat agaatgtactgcactataga
89521 agccaaagga agaggtaaat caagaggcaa gaaatgatgg aaaggtattttgctatagag
89581 aggtaaaggt tgataagact tgggaaaaag gccatcggat tttacgattaggatattaag
89641 gacaagtttc agccaagtca tgagaaactg agcatcagtt aggtccctgttgtttgatat
89701 tatgacaatg tggtggattt agtaattaga gtctttcaaa attgtctgttagtgctttgc
89761 agcttggggg catgagcaga gaaggtaggg ggcaggagga atggggagcatgtctgtggc
89821 tgagagttga aggcttgaat ggtaagagta ggcttgagga ttgtggcttgttagaaaaga
89881 cagcattaaa atatctgaac atgggacttt gtttttagaa aggatacaaatgaagttaaa
89941 agccagaaga aggtcttggg tgggattttc aagctgcatt ccttggagtcttgaatcgtg
90001 gattagagaa aagaccaccc tgtgttgatc tcagtagctt ctcctgttaaacatcacagc
90061 acatgtgctt tgaccagttt tgtatattaa ggctctatgt ggctatcttctgtcccgctc
90121 tgtcccccac ggccattctc tttccttcac catgctgctc tatgacccgggaggctgacc
90181 tatatggacc atatcagtgg gctgctttgc cctcctgctt ctgtttggattttgcccttg
90241 gggagcactt gcatgagctt gcagggaggg agaatgagag gcaaggtataatctgctgtg
90301 acctacaggg tcatcaggat cctttcccct tcaggcctag agttggtaataatgcccagc
90361 tttcttaggc ccttgaaatt tctctatacc ctgctatatc tgttcaattgcctacataac
90421 ttaaccagtg tatgcttact actcactgca gccttgatct ccctggcttaggtgatcctt
90481 ccacctcagc ctcttgagta gctgggacta caggtgtgca ccaccatgcctggttaattt
90541 tttgtatttt ttttgtagag acagggtctc accattttgc ccaggctggtcttgaactcc
90601 tgggctcaag caatcctccc accttggccc cccaaaatgc tgagattacagacaagagcc
90661 accactcccg gcccaaacat tttttttttt tgtaaaaagc caggcagtaaatatttttga
90721 tctgtgagtt atacaatctg tgttaccacc acttaactct gctatctcagtgagaaaaca
90781 gccatagatg ttaagtaagt gaatgaatgt agctgtgttt caataaaactttatttacaa
90841 aaacaggcag tgagctttgc ttttggccca taggctataa ttgaaagacccatgatctag
90901 gacaagaagt tttccatcta ctctatgaga gtggttctca atctgggataatttagctcc
90961 ctaagggaca tttgttaatt taagacattt ttggttgtca caactggaggagtagtgcta
91021 ctggcatcta gtggataaaa tccagggata ctgctaaaca tactgcaatgcacaagacag
91081 cccccacaac aaaaattacc ctgcccaaaa tatcaatagt gctgaggttgagaaatgctg
91141 gtcttgaaga tgttaaaaag attgtcagtt tgttcatcat atcgctgtggcttggcgaaa
91201 agaatcacag agttaatttt ataactatga aggattgtta ggagctgagtttttttctag
91261 ttcttatttt ttaattattt tatgatactt ttcataaaaa gtggtgtaagttgtgtttat
91321 tcagaaatgt gatttttttt tttttttttt gatggagttt cgctcttgtttccgaggctg
91381 gagtgcaatg gcgggatctt ggctcactgc aacctccgcc tcccgggttcaagcgattct
91441 cctgcctcag cctcctgagt agctgggact actggccacc atgcctggctaatttctgta
91501 tttttagtag agatggggtt tcaccatgtt ggccaggctg gtcttcaactcccgaactca
91561 gatgatccac ctgcctcggc cttccaaagt gctgggatta caggtgtgagtcactgctcc
91621 cagcccagaa attgatggtt tctttagcaa ttttgtcacc catcaagtcgttagtcatat
91681 taatcctcca taacttagtc tttttgcccc ctgattatct tttgggtgggcagtgaaagt
91741 attcatacct cttttagcaa aacctatctc ttcttggatt tcctttgcttgctgattaag
91801 aggaaggact atctgtgaaa gactcagatg tggctcaatg gaatgaatgtgagaatggta
91861 tgagtgtggg tggtgggtgc tgtgggggtc ggagatgagt ggctgaaccatccaaaaata
91921 agaatactga caagcgtgtt ttcttgtgtg tgtgtgcgtg ttgtgggaggagtgtaactg
91981 atgtggctag acaggattaa cgaaagtctc aggagttgag agagactggggacattttac
92041 caatggcgag aaggaggaag gatgacagct gggaaaatta gtgattggaaaaggtaggct
92101 gggcagtgtg gccatgagct agtccttttc attatattct tctggggctctatgtttaaa
92161 actagatact ttaacatttc agaatgagaa agagaggaaa ggatggtaactgatatgggc
92221 tattatactg tgaattttaa aggagcctat atattatcct aaaactattgaacctgagca
92281 gaactgcaac gttggtattc ttgaactgaa ctgatatttc ctttgactaatgtccttgtt
92341 caatgaccag agaccatgac actccccacc ttcaccccca cacattgtttgtttgtgtcc
92401 agtttgaaga acaatgacac atggaggtca gtgtttggat gatgtcataattttgatcag
92461 ctggaaagcc tggagtggcc ttgaagagat gcttaacttt tggaaatcacttctttattg
92521 caaccaaagc tattaagttt aaaggtccat aaagatgaga taaacagtcataaaggcctt
92581 ttgaaattca tacttagtgt gttaaatgga tttaattgct gttagttaaatgtggtgatg
92641 ttaaagcaat gtctatacac tggcaaaaat cagatcatca actgcttaatgagggacacg
92701 tcttgagaaa aacagtggaa gaaatgctgc ttatatgtaa tttgtgattaatttttgcaa
92761 ggttttcaag ggaataactt ggccttaaaa tattacagtg aaaaacagctttatacttgg
92821 gtccaatctt cttaaaatta gagttcattt ttgctattag acaccttttattacaggata
92881 actttttctt cccccttgga gacagagtct tgctctgttg cccaggccagaatgcagtgg
92941 cgtgatctcg gttcactgta accaccgcct cccaggttca agtgattcttgtgtctcagc
93001 ctcctgagta gctgggatta cagtgcctgc caccatacct ggctaattttttgtatttta
93061 gtagagacag ggtttcatca tgttgctcag gctggtctga aactcctgagctcaggcaat
93121 ccacccgcct tggcttccca atgtgctagg attacagatg tgagccactgagcccagcca
93181 gttataggat agcttctaaa cttacaatcc ttgaaatatc attttaggataattctgatc
93241 ctgcatacca gtgaaataag tataattgaa atattaaacc aaatttggcttcaacattaa
93301 accaaaatta aaccaaatta agccagtatg ttaaatacat agtttaatcttaattctagt
93361 taatattttt catttcctat gtgtcaggca atatactaaa caacttacatgtattactat
93421 tttaattctc ctggtaaact ggaggggtgt gcaattattg tcatctccattttatagatg
93481 aagaaaactg agtcataaag aggttatgta cttggctgaa agtcacacagtcagtgatac
93541 tgttggaatt tgcacccaga caatttaatt ttagagccta ttttcaaccactctctgaga
93601 ctgctttcct tttctgtact tttgatgata aatgtgaaaa gataattttgagggcattat
93661 ggtgtattgg atcttaaaaa cccaggtaat aagtcccatc tatagtacaaataagctgcg
93721 tgatcttagg gaaatcacat aactgcttct gtaaaatgag agattacattaagttatttc
93781 caaaatgtct tttcgacttc aatgtggtga ttccatagta atgtataggtttttaaaaaa
93841 ccatatcctt caatcaaatg gtcatccttt agcattaagt tgtttggaatagatactccc
93901 caaattcaca gaataatttt ccagcctctc tttttgcttt gacacctttcttattttttt
93961 tttttttctt cgagataggg tctcactcag tcgctcgggc tggagttcaatggcacgatc
94021 ttggctcact gcaacctctg cctcccgggt ttaagcaatt cttgtgccttagcctcctga
94081 gtagctgggc tacaggcgtc cgtcaccaca ctcagctaat tttttttaatagagatgggg
94141 tttcaccatg ttggtcaggc tggtctcgaa ctcttgacct caggtgattcctcggcccta
94201 gcctcccaaa atgctgggat tacaggcgtg agccaccgtg cccgctattgaccccatttg
94261 ttgatgctta gggatgaaag tggaaactcc actgctaaaa cagagaatattacttgagtc
94321 attcctctgt catatatggg atgtttgcca gcatggaaca ttcacagaaattataactgt
94381 aaaggcccta gcaatgattt aatgccgtct cttcacatta tagttggggaagctcaaact
94441 gtgacagggt cagggacagg taaaattcac aaagttggtt tacagcagaactgtgctaca
94501 gttatctgga ttcagatcca agtcccctcc aaatgaatca caaccacttctacctttata
94561 attccaggcc atgaaagatc actgttttag tctgcgtggt gcagtggaacagatagacct
94621 cggtttgaat ctcagctcta ctgtttacta gacatgaaat ggggaaatctaaaatgagta
94681 agtatacaca gaaacacaca ttacatacat atatgtaatg ttcaggatcattacactgaa
94741 ctttagggct tagtactaat gtacaatcaa ggttgtgtta gtactgagcagtatatcttt
94801 tattgttgaa gtccaataag aacagagcag atatcaacct aatttgtaagtgatgcattt
94861 tcctaaacta aatgcccaat aatggaatgg gctagaatat tgcaggacagggctgtgaat
94921 ggaggaaagc agttggaaaa tcaatccttt taaaggcaca aaaggatgaatgaaccacat
94981 tcccaagaac ctgctcccac ccactgctgt tcccaccccc gctgtagttggtagcatgtt
95041 cacaaggaag gagctggcta gctttcatgg gagccacatc atccatcaaatcacattagt
95101 gttgttgatt tgaatgttgt ttcctttgta ggtctgcttg ctttgactttgtaaaattgt
95161 ttagtcttgc cattattata taaggactat aatcataagg catttatatttcattttgta
95221 ttatgtattt aagcaaaatt aagttaaaaa ttagacagag atatataggatgatttttcc
95281 ttcaagagtt attcatttat ttccttttgg atatgaaaaa cgcttatgcagtcctgtatg
95341 tggtctctct ctctttttat ttttatttat ttattttttg agatggagtcttgctctgtt
95401 gcgcaggctg gagtgcaggg gtgctatctc ggctcactga aacctctgcctcctgggttt
95461 aaatgattct cctgcttcag cctcctgagt agcttggatt acaggtgccagccaccatgt
95521 ccggctaatt tttttgtatt tttagtagag acggggtttc accatgttggccaggctggt
95581 cttgatcctg acctcaagtg atccgcttgc ctcagcctcc caaaatgctgggattacagg
95641 catgagccat tgtgcctggc ctgtggtctc tttttaaatg tttgagattttctctgacca
95701 tcacatgatg gcagccgcaa gttgtaaata tattaaatga gataataccaaatggcataa
95761 gaccactgtg aattcagtga tgttccaaaa taacttgtat tttattcatcacacaggcat
95821 ttatataaat taaaaaataa tagcacctga aaacatgaaa ataattgtattcaaggttat
95881 ttactgcagc atgattttta agagaaaaga ctggaaacaa cccaaatgtccactaatcga
95941 gactgtgtga acccaagatg ttatagctgc atcacacagc tgagagaaggaataagatct
96001 atttctactc actgccagtg gtaatctcca ggaagcgctg ttaagtgaaagagcaaacta
96061 gagaaaatgt gaatagtggt taccatttac ccaagaagtc tatgtgtggtgtgtgtgtgt
96121 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt atgtgtgatt tctagagggacagaggaaaa
96181 aggtgaagac aaggatagga gcgagacttc tctgggtaca tctttttttttttttttttt
96241 ttttttgaga caaagtctca ttttgttacc caggctggag tgcagtcgcttgatctcagc
96301 ttactgcaac ctctgcctcc ggggttcaag tgactctctt gcctcagcctctcgagttgc
96361 tgggattaca ggtgcccacc accacgcccg gctaattttt gtatttttagtggagactgg
96421 gtttcaccat gttggccagg ctggtctcct gaccttaagt gatccacctaccatggcctc
96481 ccaaagtgct gggattatag gtgtgaacta ccatgcctgc ctgtctggatctctttttag
96541 tacatttgac tttgaagcca agttagtatt ttccataatt aagaaaaaaatagaataaaa
96601 aaggaacaat ttctaaaaag gaagtcaaaa gaaacacatt aaactaactgtaagttgagt
96661 tggtagcata accacacaga cagaaattat ttcaagtgac tttaacacatactgatgtga
96721 ctgtgcatcc ctatcgagat agaaataaag gtaaatataa ataaaggtaaaaataagcaa
96781 gatataaata aagttaaaat gaactgcaac aatcctgaat agttttcaataattatatca
96841 taaatagtaa ttttggtatt gttattttaa aacagttata tttataatacatatgttaat
96901 gtaatcatgt ttatgcttat cataacatat ggatgcacag ctattaggataatgtataaa
96961 catgattatg ttaatgccat tagggaccaa gatttcagag aaaaacaaagaaaaatataa
97021 aattaaagaa gccagtaaaa atgttatctt aaatttaaac tggaaacctcagtataaact
97081目录tttcttttaa aaaattattt tcaaattcag tctcctgaat agaactcgca
97141 acaattacca agccagtagc aacgacaata aacagcccta gtgcccagatggtgctctcc
97201 aaatgccatt ttccactaaa aggaatgagg gctccttgga gaattggatgttttcagata
97261 cagagcagaa cacatacaaa aagttcctgg aacatttgtc atactgaaaagcagatacac
97321 tatgaaagac tatagtaatt gtatcaaaag aactcaggag ccaccatgaagaggccccca
97381 gtgtccagaa atggaataat gtgaacatta agaataataa atcttaatttgtcaagatac
97441 aaatttaatc atatcgtaga tactcatagc agcattattt aaaataatgaaatattagac
97501 acaacttaaa tattcaaaac tagcagtgtg cccttatata tagaaatgtcatttaaacct
97561 tgtagaagag aagtttatga tttaggaaga tgtttacaat atgctgtaaaacacacacaa
97621 caagtcataa aatattatgc atgcagtata ttccagttta ttttaaatgatctaggtata
97681 aatatccata aaaagaaaac tgaatgaata aatggtgaaa tgtgaatagttgctatatct
97741 gtgtggcagg attacaggtg gttgtattct agtttctctt tatgttccaatcttctacag
97801 ttagcatgta taattttata tttttttaat acaaaatatg ttatttaactagtatttact
97861 aaacaaaaaa ttaaaaatta atatatttta taaaaacaaa agcatatgaatagaaaagta
97921 cattattttt taggttatag acaatgcttg tacctgtgtt tagggatttgatcctccagg
97981 taggaaacta cagatctaat ttaacttatt taattaatta attaattaattaatttattt
98041 atttatttac tttgagacag agtctcgctc tgtcaccagg ctggagtgcagtggtgtgat
98101 ctcggctcac tgcaacctcc acctcctggg ttcaagtgat tctcctgcctcagcctcctg
98161 agcagctggg actacaggca tgtgccacca tgcccagcta atgtttgtatttttagtaga
98221 gacggggttt caccacgttg gccaggatag tctcaatctc ttgaccttggaatccaccca
98281 cctcaccctc ccaaagtgct aggattacag gcgggagcca ctgtgcctggcctaatttaa
98341 aaaattttta agtcaccaaa aagcaaagtg acatgctcaa gtccattattgccaagcaaa
98401 gaaaaaaatg tcaaaagtac aaaatgtggt tatgttttaa aaattagattattattatta
98461 agataggatc tggctctgtt gcccagacgg gagtgcagtg gtgtactcatggctcactga
98521 agccttgact tcttgggctc aaatgatcct ttcacctcag cctcctgagtagccgggact
98581 ataaggcagg caccaccatg cctggctaat taaaaaaaga attttttttttgtagcaatg
98641 aggtctcact atgttgtcca ggctgatctt gaatgcctgg actcaagtgatcctcctacc
98701 tcagcctctc aaagtgctgg cattacagtc ctgaaccacc atacctagccagatttctat
98761 tactttgaca tggtcctgga tacttcatct atgtgtgcaa aatttcgtacttatctctta
98821 aatctggaga aaaatggcca aatttggtat agttgaattt atcatggggtgattaataag
98881 tgactaaaga ttgaccttca aggatctgaa gatctgacca gtgtagatttatagtaatta
98941 tagtaattac atggtacctc caggtatttt ctatacattg ccgtagttagctatgaaagg
99001 atgtaaagaa taaaggcaat tgactatttt aaagaaatta acctcagaaggagattcttc
99061 acctaaatgt ccctgcaaat attattgctt tatgctctga gttagctgaaaatgagttta
99121 ctatgcctgg tgtaaacact tgcaccaccc acctgtgtca aagaacttttcactaactgc
99181 atcatgactg attgacgtca gtctacttgg caaccaagtg agccacttagaagaaggctc
99241 cccttatgag gttaatttct ttaaaatggt gaattgccct tattccttatgtcttttcat
99301 aactgattac acaaatgtat agaaaatacc tcttgagata caatacaatctgtaactagt
99361 catcagagaa taacacgtta ttgtaacaca gatttagctt ggccataaagggcatattta
99421 catacacatt gaaaacaact ttaataaaat gaaaaacata tatccttggattcttagcaa
99481 tttaacagca atgctctcag gggatcaagc tactatttat tgactccccctgtgtgcctt
99541 acacgtaatt actgaccctc acaacatccc tgggagttag tgtcttacaggagacctttg
99601 acatttgtga gaggacatcg tgaatatttt ccaagtcctc aatccaaaagtgtggacata
99661 gctgttggtt ttcctgaatt gtatttcttt caagaatcaa atgttgcttgtgaatattct
99721 catgtaagat taaaaaaaat cttttcctga ctcttagaac tttagttttatctctgcttt
99781 gagagccact ttaataagca aactaaaatc actctacaga aaggctgtacagcaaatgag
99841 tagagaacaa aagctggcta aactgggcag tcagctaaga tcactcagtgtctgagaatt
99901 tgttctagaa aatcaccctc cgagaatcat gcagattgtg cttaggcttccttcatatat
99961 tcatactctc ctcgggtgaa cataaattgg cacatttata aggaaattttattattatat
100021 actcaaatat ttttaaacat ataaatagtt tgtcttgtta attctacctcttggaatcta
100081 tcctaaggaa aataatcata agatatctgc aaagaattat ttgaatgttgataataattt
100141 tatctataac aataaaaatt tgcaaggtgg cagatatcag tttatgtctctgagctccaa
100201 atccaccctt gtttatcttg ctttgtgtga atggagctgg accctgtggatctttctctt
100261 ttgcaaattt gggggatatt caactttgtc aattgagggc actggagagaccctgcaatg
100321 gaatagaggc tccaggtgca cctacaggcc atctttccct accagcagcgatttcagagt
100381 aacttcagcc tgtccatacc ctccagcaat ggtgggtcac ttctatagatgaactctggc
100441 ccacccgcag caccaagcaa aggaaggtca ctcctgtaca ccagcttccaaccactctca
100501 tccaccagtg atgatagatt gcttttatgg atcaatgcca gcctttgcactcagtcgttt
100561 ctttgttcct gcaggctgcc tgtggtagtt actatctctc tgaagaggtctgaatctcag
100621 ccttggggca aggagggctt gtcctcatcc ttagtgcctt tactgttcttcttcctcagc
100681 ctagaaataa tagctccttt taaaattctt gatgcctggg cctcttagagtcctccttta
100741 tatatctttt agtaggtaat ttttggaaca ttaaattttc cctgttcaaataattatcat
100801 agtttttgtc ttccacttgg accttgaatg atacaaaagt taaaggctcaacaataccag
100861 acttgttaaa taagtaggga gctatccaca cactggcata aaattgttttgattatctat
100921 tattcccttg gtgaggtgac ccagaccctt gtttgaaagc gttttattggctgggtgtgg
100981 tggttcatgc ctgtaatccc agcactttgg gaggctgagg tgggcagatcacctgaggtc
101041 aggagtttaa gaccagcctg gccaatgtgg tgaaacccca tctctactcaaaagtacaaa
101101 aattagctgg gtgtggtggc gggtgcctgt aatcccagct actcgggaggctgaggcagg
101161 agaatcactt gaacccgggt gtcggaggtt gcagggagcc gagattgtgccactgcactc
101221 cagcctgggt gacagagcga gactccatct caaaaaaaaa aacaaacaaaagaaaaacaa
101281 caacaacaac aaaagaaaaa acaaaaatga aagaaagggt tttatttgtcttctctctct
101341 ctccctgttt tttttttttt tctttttttt ttttttgtct catctttgctgtaattgctc
101401 atttgctagg gtcattggac acagagatac caagatgtct tcagaaatcatgaatattcc
101461 ccaagtcctc tatcaaaaag tgtggacaga gctgtcggtt ttcctggggtttagacatgt
101521 tctttcttgc ttctgttgtg tagtaaccct agctcctcaa ggaaatcgtggtctatgggc
101581 tctgccaaac agtaattcct ttctttgctt gctggctcac tggcttgaggaactcaaagt
101641 aatcctttgg taatttcagc ttccaggtca gtggggacat taatgtgtttcttggtagaa
101701 atgtcactct actccaagaa ataagatctt taatccagaa aacctgagttttcagggaca
101761 gaatgcacaa acttttatgg tcattcactg ggagttctaa tgagcaggttcgatcatatt
101821 tctattcttt agttcctcga cccatgcatt ttagctactg ggcggcgaaccatgtatcag
101881 ctgttagtgc tgtgtgtatt ccatatcatg aaggtaattt cccaggcccacaacgttttc
101941 ttcccaagct ggtgccgtaa ctgagccttt accaggctat tccatcattttaggtgtttc
102001 tagggtatag agtaaatgat aagaccagtg actcccatga taaatgtgcaccatggtgaa
102061 cttcctttgc tgtaaaatgt catcttggtc ctagtctata tcgtaaggggcaccatactg
102121 atagaccagg tactggtgag cccttggatg gtggtactgg tagaggaactgcaggaagaa
102181 aaggtaaatc catactcaga atatgtgttg attctggtaa ggacacgttgcttttccctc
102241 caagacagat ggttccgata gatggttgtg tagctaccct ccctgaggaacggtactatg
102301 tcaaggtctt ggcatcagat tccgtggctg acaggttgga aatttagcattgacagtagc
102361 tgaattatct tttgtaagtg ggagctcaaa tatgaccatg catagcaccatagtgattgc
102421 agcactagag acactattta tgggctttcc tgcacaagaa ctggggtggctaaagacggc
102481 ccggctaaaa ggcaggatgg atcatcctga gcacatggtt gttgagagtcttctttgcag
102541 tcgggcggta gtgtgagatc tgctttgtgt ttatttccgt agggttgtccacatacattt
102601 ttttccccac accttttctc tgagcttcaa atcttttttt cttgtcctgtcgaaatggcc
102661 aagccattca ctactgctta gaagccagtg catacttaag gatctggtcttttcttccat
102721 atgaaatgaa taactaagtg tgttgctcat agttttcccc actgggaggatttcccttta
102781 cctctcttct ttggggccac ctcaagtgag gatgaaatgc aacagcagactatctctggc
102841 tagaggcaat aaatcacact agcccaatta tgcaccaggc ctgagctgtttcctccacta
102901 ctgattgttt gtaggtagca gttgtgggag cttctgtgga acagattcaggtggtacagc
102961 tgctcaaact cataactcac ctgcaatgtg ttctgaaaat gtgtggcttaactgcatcta
103021 ccctaaaaga acaagttggt gagtgatgag atgagtggga agtagtgaggatgacctgga
103081 ttttccattg aggaagtggc caagtcctgc ggacaaattg tacctaggaaaaggtacaaa
103141 aacaggagaa tggatcatgc gttcagtatt ggaactgatg actattaagttgctgtgggc
103201 atctgaatat agatgttgtg atggttttaa aacatgtctg aaaattctttgacactgttt
103261 ccatcaagag gtgatgtctt tgtctcctcc ccttgaatct aaatgggcctttgtgacaga
103321 tctgatgaat agaatgcagg aatgtgatgt ccaaggctag tttagaaaagaccatgtttg
103381 tttctctgga gacacttgct ctgggagcta ttagtgtcct tccaccaaagccccccagga
103441 acacccctgc agctaaacaa attggattta ttgcttattg tagcaagacagaacattcac
103501 cagggggaac cataggttat ctcagtaaga gggttttaga aagaacctattataagattt
103561 gggctttggt tgggtgattt gggggaaggt ttaaggaatc aggggtggccaggcacggtg
103621 gctcacgcct gtaatcccag cactttggga ggccgaggca ggtggatcacgagatcagga
103681 gatctagacc atcctgacta acacggtgaa accccgtctc tactaaaaattcaaaaaatt
103741 agccgggcgt ggtggcgggt gcctatagtc ccagctactc aggaggctgaggcaggagaa
103801 tggcgtgaac ccaggaggcg gagcttgcag tgagctgaga tcgcgccactgtgctccagc
103861 ctgggtgaca gagcgagact ctgtctcaaa aaaaaaaaaa agaaaaaaaaaaaggaatca
103921 ggggtttggt ctagattgaa tgctctcaga aaatgggagt aattctagggttgtatattt
103981 tataggtggc atagtgacct tgttttgtct gtccttacac aaatgatgaagtaggctgat
104041 tttgtttcat tttatcttgg tcgcagagta actttgtctg aggttggtgttctataagat
104101 tgtatatgtc caacaagaga atgacatggc ttagctgtga atgtcagatcagttctggat
104161 atgagaggct gatattttct ttttgagctt tcagttgtca tgtaaggagtgtggctacca
104221 tgaggccact gcatagagtg attgtatacc tatatataag agagatggtttggagttcaa
104281 gcccccagct agtcaagtct tcccagccca ggagacagatgttcgaatgaaggagactta
104341 ggtaatttca gccccagtca ctgtctgacc acaactgcat gagagaccctgagggagaac
104401 tgctttgctg aacccagtca acctccagat ttgtaagtaa aataaatggttatcattgat
104461 tgaagtcact gttctagggt ggtttttcct acagtaatgt cattgatacaggtgtctggc
104521 aggcagttgg ctctagaggt ctggagctaa ggagaaagat ctggcttggagatgtggatc
104581 aggaagtcct tttacaagga gaaaagtgct tgaagtcatt tgagtggatgacatcacctg
104641 aaagataata tacattgaga aagaaaaaaa taaaaagcca acaatagcacctttagtaac
104701 aacactgaag agagcaggaa gaaataaaga aacatttgca aggagacagagaaggagtga
104761 ataaggtgat caaatggcat ccatccaaga gatgatgtcc aggaagccaagaatgagagt
104821 atttcagaaa gaagagtgtt gtccacagag ttaaatgcta tggagagagatggagtaaga
104881 caagattgat tagcaccaat gagctttcat tgttgacaaa tgcagtttgagggaaactgg
104941 gggctaggga gtgatggggc agagaccaga atgcagtggg gtaaggaggggtaagaagat
105001 gagaagaatg ccaaatctgt gctgtttgcc acatcatggg ccctctctccatactattta
105061 tgtgtgtata atttttttct acaatttaat aatgcattaa accatcacatcacatcacat
105121 cacaaaccca acaattccac aatagcatgg gtagatcata ccctggtgtatttttaatgt
105181 tatactttaa ccggtagttt tgagtcataa atgtactact atgttgttggtttttttttt
105241 ttttttgggt ctgtcattat agtaataact ttaaatctct tattgtttatttctcttgca
105301 attaaaatag ttcatcattt aaaatagtac ccagtgttca gtgtccattggtgccttgta
105361 attacttcag aaaaacagtc tcagtttaaa agttataaac tcttaatgcctctctgcagg
105421 aggaatagct tccttctgcc agagcggtct ggggagcatt attctagtcataccctgcta
105481 attcattggc ttgattgtca ggggtcctga tctagttcac cctcctgggaggctggtgtg
105541 ggaccctgct tatcccagtg ggggtcaagg cctccttgac aacagtgaatgggttgctag
105601 gaggctgcgg aaagaaattt ctctagttcc atccacaagt agatcccactgcagtggcct
105661 catttggctc ctctaatcct ctctttccca ccttctttca gggcaagtctcaccctattt
105721 tcttcattac ttgcttgtgg tttccttgcc ggagatgctt ggaggcaagcattatgacaa
105781 ggatgggcgc gggtgggagt aaggccttta aacgaagagc tacatttcaaagaacttcaa
105841 atgtgtattt caaatgtcac ttccaaatga ggttgtacac acagacagaaacgcaattaa
105901 cagatttgga agaggccacg tagcatgcat ttgaaactcc tgttgcattccttggctatt
105961 cttgtctgtg gcatcttttt aacaaatcct gtagttacct tgtaaataccatcatagaat
106021 atattgtatt taaaaaacat tctttactca gatatgaaag ttgaaaaggtactattattt
106081 ttaaaaatct gtattggatt tttttttttt catattttag gatgccagaagcctcaaaaa
106141 tggaaaaccc cctgtgcttc acatctgaaa atctctgctg ggggcagcaactttgagcct
106201 gtggggaagg aactgtccac gtggagtggt ctggtgaatg cttaaggagctgcagaaggg
106261 aaggtagtga ggagacagtt aaatattgag cacgttttgg tgcctagcattgtactggcc
106321 tttcacatgc tatgtttaat cacgcaggat tgtatggaat gggattgtacagaatgaggc
106381 ctgggtttgc taaatcctgg gggagattgt ctaagctgtc acttgaagggaaaactgtag
106441 catgtgggac ttaaaaacag cttgggatgg agtttgaggt agggcgagagggaaaaagat
106501 cttggcagat acattctgaa caaatacttg tgtcatcctc aactgtatagtttttatgac
106561 ttttcctgtg ttcatctggt tggcagatga atgcaaaatg ccttttagcttcatggaagg
106621 cacacatgaa tcatggctat gtgataaaca gaagaagcca cgtttcggagggtttctggt
106681 gtgtgtacgt gtgcacttgc atgtgtgtgg gcacaccctt gtgccaaatggaccaccagt
106741 ttaaatcgat tttcaacagg gcagatttca tatgcttctt tagtgtggcccaagtcaatc
106801 tatttttaga aggggaaagt agagcatgtt ctgaaagttc ttttcttctgccatcaggga
106861 ttgtagtact ttttatttat agtaatttca ggtctctaaa tacttcaagcaaaattaatg
106921 aggcaaacaa aaaaaattag gtaccagata attggatcat gtgttattttatagagagct
106981 ttatttatct tgcctttgga aagtataatt tgtatttttc aaaattatgattagatctaa
107041 ttctttttca agatttactt aaaataaata tttctgccta ggcacaagactgtgtatagc
107101 acaactggcc ttgtattatt gacttgatga tgcaaagaaa aatatataagaatcagtttt
107161 ttttaaatgt gttaatattt atcataatgg aaatagtctt actaattagcaataactaga
107221 aaaatgtcta ctatttattg agccactact atatgccata ttctttacctatgttcattt
107281 tctcttctat attcaaaata atcctataag gtgtgcttta tgatcaccatttgttccaat
107341 agggtctcaa ggacgttagg taattattcc tatgacattg agcctatgaatggcagagct
107401 gggagtttga acctaagtct gatgactctg aagcttatag tctttctataagcttcttca
107461 gtctgaagct gcccctcaaa gtcatggcaa taactgagaa tagcattcagttttacagct
107521 aggaaggtag ttgtagttgt gtttattatt caatactgtc catattcaaagaaccattca
107581 ttgagcttct attttactcc agtcacggtg ataaataatg cagaatctagagatcaaaga
107641 taaaatggcc ttgccctcaa ggaacccatg agctagttgg gaaaactaataggaatatta
107701 atgattataa tgcagaatgt taggtgcaat gagagaggta acaaggtactactggggcct
107761 gacaaaggcc accgtttctg tgtgtgtgtg tgtttatgtg tgtttgggaaaaggcaaaag
107821 acacttgaga taaagggaac aacatagaca aaatcaaagg cttgagagcatataacttat
107881 atgagacata gcaaattgtt tgctttaact agaaaatagt ggttatgtgtggcagactat
107941 gagaaatgag aatgtaagtc cttgagaatg ataactttag aaattctacatttgggatga
108001 tcataacctt ttaaaattgt ctcaatatga tagatatttt ccttctgttttggggtatct
108061 gtctttttat tttttatttt tttgaggtgg agtctcactc tgtcacctaggctggagtgc
108121 aatggcgtga tcttggctca ctgcaacctt cacctcctgg gttcaagcaattctcctgcc
108181 tcagcctcct gagtagctgg gattacaggc gcctgccacc atgcctggctattttttgta
108241 tttttaatag agatggggtt tctccatctt ggccaggctg gtctcgaactcctgacctca
108301 gatgatccac ctgcctcagc ctcccaaagt gctgagatta caggcatgagctaccacgcc
108361 tggcctgggg tgtccatctt ttaaagacac actgtaagaa tcataatattttcccaaaga
108421 agaaatgtaa ttagtacaca attacatgtt aaaactaggt gttattggtaattaaaattt
108481 aaaaaaatta acccaaccaa ataataaaac taatgaaaat atttaatattggtaagaaca
108541 agatgcgata agcatatttg tgttttgctg attggtctat aaagtggttcaaaacttttg
108601 taaactatat ataagctatt ttaaatgttt atgccctttg attcaatagcactaggtttg
108661 gtactttata ataggaaagt tattagaaat atttactgca gggtttcttcaatgatgagt
108721 tgtaagaatc agcctaagta gctatggtac atcactttga tgcaacttaatgtgtcatta
108781 aaaatcatgt ttatgaataa cattccagat gcatttaata caattctagctgaaaaaaag
108841 atactgaaac attttgtgtt tatatatgtc tgcatatgta tctatatatatccctctccc
108901 tgtcaatcta taaattaaaa actatacatt aaaaactgca aattaaaactatatactaaa
108961 gaaagaaact ggaaagaaat ccacagaatg ttaataatca tggtcattgtgttgagtggt
109021 aggactatgg gtaatttttt ctttctattt ttatacattt ttcacttttttttttttttt
109081 caatttgagg cagagtctca ctctgtcacc caggctggag tgcagtggaacgatcttggc
109141 ttactgcagc ctctgcctcc gggttcaatc aattattcta cctcagcctccagagtagct
109201 ggaattacag gtgcacacca tcacgcccgg ctaatttttg tatttttggtagagacaggg
109261 tttcactatg ttggtcaggc tagtctcaaa gtcctcccaa agtgctgggcctccaaaagt
109321 gctgggattt ggcctcccaa aatgctggga ttacaggtgt gagcaccacacccggcccat
109381 ttttcacatt tttaatgatg tttttaactt taaaagtaaa aatttgtaatttaaaatttg
109441 tttaactttt acaaataaaa attacaaatg caaattaaaa ttgctatatatttttgttac
109501 tggacaagaa aagatgcatt atagagtctc gttttatttt gttttctgataaatctattg
109561 ctggggagca tgtgcgtaat tcgttttaaa aattctcagt gttaactagatttcttttgg
109621 gatagctctg ctgaactgga atgagatctt cttccccaga gccacttgctagtttgattt
109681 tctagaaaga gagaaattat agaaagctac aatctacaaa ttgctatgtactacagtcta
109741 ctaaatagta taatacttta ttttgcaaac tatatctctc agagtacaaggctccacagc109801 tagtcttgca ccaaatatat gaggttcttg aatagtcatt ttctcaaagttctcatctct
109861 ttacaaagca agttgagggg ggaagcagag agagcactct ggtgcttccaaaagcatcag
109921 ccatccacac tctgcctatt gaaaacacca aatctgagca tgtgtgtcattgtccaggaa
109981 taaacaatca caaaaaggca tcaatgaggc ctataaaaac aagagcgcatgcaagaagat
110041 gggattgtta tgaaacagga gcacaaggct actaaaagag ggcaagcctaaaggaaaagt
110101 caccagggtg agatggaaat agatatagga agaatagtga acggtggcaaggaagtaaag
110161 gaatacaaaa gtaataaaat atccattgca ttagtccgtc cttgcattgctgtaaagaaa
110221 tacctgagac tggataattt ataaagaaaa gggtttattt ggtttatggttctgcaggct
110281 gtatgagaag catggtgcca gcatctgctc ctggtgaggc ctcaggaagcttctattcat
110341 ggaggaaggt gaagggggag ctagcatatc acatggtgag agatggagtgagagagagag
110401 agaaagagag agaggagatg ccagtctttt aaataaccag atcttatgtgaactcagagt
110461 aagaactcac ttatcatgag gacagcatca agacattcat gaggaatctgaccccatgac
110521 ccaaacacct cccactaggc ccacctccaa catgggcagt cacatttcaacataagactt
110581 ggagaggaca gaacatccaa accatatcac ccacattgag ggagcaaggagcagactcca
110641 tactgcagaa cacacatggg aaacaaactt gagaagtttc cccagggcatagggtaagag
110701 gacgaggggc tggaaaaaga aaggtaatgg atatagagga cagagaatggagttcgaaga
110761 tacatctaag aactttacat attcctaagg aacccacaaa gataaaacaaacagagcaag
110821 tatgaaagat gtaatagaag caaatgaccc tgcattgaaa atgatcaaagtatgcagatt
110881 ggaaaggctc acaaattcca ataaaaagaa ttgaaaacaa aaaaaaatgctgcaataaca
110941 ttctttaaac tatattaatt gtaaggtttt tacaaaaata agtactcaggcagtagtaaa
111001 aagtttgcga ataaagaaac caaaattaaa ctctaacttt tcttatgtaataccaaattc
111061 cagaacttgg aaacatatct gcatgcttta ccagggacca gattatgaggcagttattta
111121 agattagaaa agttctcttt cattggtaaa ggcaacagaa agatatattttagaggtaga
111181 agctctctaa catagacact attctgccaa aaaaaaaaaa taagataaatgtaacaaaat
111241 aaaatgagct tcaaggtgta ttttggtcac tgagagatga ttcaaaagaagactttgaac
111301 aatgagaatg ttaacattta aaagaatagg tggaattttt ccttactcagtttgttcaat
111361 aaaatcatgg gtccactgta acctgatata tcttgttgct taaagggaaagcttggccct
111421 accttttctg ctttcttctg tgttcatggt gtagaaaatg tatttttgttaaccaattat
111481 ttacttcaca cttgaggtag actttgttgc catgttggat ggctattttgttaggtcaaa
111541 cagttttctg ccacatgcct atgtgatttt aaataatgta gccctcaccctgagcttctg
111601 ctatagggac cacatgcttt gtggtaacca ggtgctgcca aaattggatgatagcaggct
111661 cctgacccat gcctgtcaag tcataggtgg ttaaggtcat gggagttggagtcagactgt
111721 ctggttccaa atccaaggtc taccagttga ttttgacctt aattttcttattctgtaaaa
111781 tgagtttatt gattgttccc actcagttcg tttgaggtga ggattaaatgagttaatacc
111841 tgtaactttt tgactggcac aagacacaat cctattacat gttctgaaaaaaaattctct
111901 acatgaacca aaggaatgaa ttctatttcc tccactgcta ctacaactcaacacttctaa
111961 tcaccaaatg tgtggaggtt tttctacatc agtttgtcag acacctactatgtgtcctat
112021 aattcagttc agttctgaca ccatctacat ggaaacaaca tccgatcccatggactaaaa
112081 gctcagtctc ataagactgt ctataatggc tcaagtgggt tcttcttgcctgctgcacag
112141 aaaaaccaat acatcaaggc agtggtgttg cagtagagaa agcatttgataatcacaagg
112201 ccagccaagt ggaagcatgg gagataattc ttaaatctgc ctccccaagagctcaggggc
112261 tagggttttt aaggataatt tggcagacag gggactaggg aacgagtgctgctgatgagt
112321 tgtggatgaa atcataggag tatccaaact gtcttcgcat gctgagtcagtttctgggtg
112381 gaagtttctg cgtgggagtc aatttcttgg catgagtcac aggtccgggtggagtcagtt
112441 agttgccaga atgcgaaagt ttaaaaatat ctcagagacc aatcttagattttgacaata
112501 gtgattttat ctataggagc aagaggggaa gttaaaaatc ttgtgacctctggctacatg
112561 attcttgagc agtaactatt atagaaaggt aagctaggga acaatgtctggttatcattt
112621 aattacacct acatcttagc agaatttaag ttcttctcat aagcccaaccttgtggactt
112681 tcattagtct tacaaaggca gtttcagtcc cccaccaagg agggcattagtttcaggtag
112741 ggactgttat catctttgtt ttaaagttaa aaaaggcagt tagcttgtgatgttagaaga
112801 aagatgtcag atttctctca ctgtcataat ttttgcaaag gtggtttcatggccccactt
112861 gaaatgagaa tgggaagtcc aggttttcac ctgtgcttta gactgggtggagataaatta
112921 aaggttcaca ggacctcctc ctcagatttg accatttgct agaatggttcacggaactca
112981 gaaaaacagt ttacttattt gattaccagt ttactttaaa aggaaattacaactcaggaa
113041 gagccagatg gaagagaggc atagggcaag gtatgtggga aggagcatgaagcttccgtg
113101 cattcttggg ctcatcaccc tctcagcacc tccatgtgtt cagcaacctggaagctcttc
113161 gaaaaatgtt cttaagccag gtgtggtggc tcacacctgt aatccccgcacattgggagg
113221 ctgaggtggg tggatcatct gaggtcagca gtttaagacc agcctggccaatgtggcgaa
113281 accccgtctt tactaaaaag agattagcca ggtgtggtgg cacatgcctgtaatcctagc
113341 tacttgggag actgaggcag gagaattgct tgaactcagg aggcagaggttgcagtaagc
113401 caagattgtg tcactgtact ctggcctagg tgacagagca ggactccgtctccaaaaaaa
113461 aaaaaagaaa gaaaagaaaa agaaaaatgt tccttcagat ttttatgagggcttcattgc
113521 atatacatgc ccctccctgg aggttggtct ggaggttggg ctgaaagttccaactctaac
113581 cacatggttg atttccatgg caacagccct gcttatcatt agggacttcccaaaagtcac
113641 ctcattaaca caaactctgg tgtgactgaa taacaaaaga tgctcctgttacctttattg
113701 ctcttagaaa attccaaggg ctttaggggc tttgtgccaa aaacaaacactatatatatc
113761 ttattataaa tcacactatc tcacattatt attatttaaa atgataagtcagtcaagctc
113821 tcttttcttg agaatttgat ttgggaaact tcgagaatga ggcaaggagcagtgggaata
113881 ggagtttaaa gtaagcatag aaagcataga aagaagctag ggaatagattaaggttgcaa
113941 ggagggataa caaatggaga ttaggaaata gtggagactg tgattaagcagagcctgtca
114001 ttaggcattt ctgatataaa cccagatgct gtcatatcac ctcactgaatgcttgccctg
114061 aaacacttgt tttagtgcag ataaattcat cacctaagga tggcttatcctttctatggc
114121 cattgaactt aagagctcca ctaaatagga taactccctt tatgctgggaaatctaccaa
114181 aattacctgt gtcagaaggg taagaaaaga gaatccagga tccagaatgggattgaagtg
114241 atctcccatt ctttttgtga tatttagact gccttctgcc tctccaatcgacagaataaa
114301 gaccaaactt ctacccgggt gggtagggct tatcctgagg atggagactttctaagtata
114361 gatggtcaag aaactggtgc acatttaagt tagacgcatc tctaaattgtctgggcttag
114421 actattctaa gaatgaataa ttatgaaaat tgaggcagct cagagactcattttctaaga
114481 tttcaatata tgattagcaa agtgctatag aaaaaaataa aatggcacagtttggcagtt
114541 ggcatcttgt atctttctgt cccaggtctt tcttgtgctt gtaattctttcattgataaa
114601 gaactcagct atctatccag gcgtgatggc tcatgcctgt tatctcagcactttgggagg
114661 ctgaggcggg aggatcactt gaggtcagga gttcgagacc agcctggccaccatggtgaa
114721 acccacatgg tgaaacatct gtactaaaaa tacaaaagtt agctgggtgtggtggtggga
114781 gcctgcagtc tgagctactc aggaggctga ggcaggagaa ttcctcgaacctgggacttg
114841 gaggttgcag agagccaaga ttgcgccact gcactccagc ctgggtgacagagcaagact
114901 ccatctcaaa aaaaaaaaaa aaaaggattc agcaatgtgt ggttcttttgaatctatggt
114961 atgtattagc acatcacagc agagcagagg ttctcaacaa ttgattttattccccagggg
115021 acatttggca atgtctggag acaattttgg aacttagagg ctgatgctattttggaactt
115081 agaggcttag atgctattgg tgttgtgggc agatgacaag agagattgcaaacgttctcc
115141 aattcagaag gcagcctcca caaaaagaat tattcagtcc aaagtgttaatagtgctgtt
115201 attgagaaac catgccctag agaagcagcc tagaactttg agtttttccttttttttttt
115261 tcaatcaact aatgagaata aatgtggagg agacgggcaa aaatgtcagcagccccgtat
115321 ggttttcaaa atcatttcag atatttgcta ttcaccagtg tcagccaatgtgtttatttt
115381 tgaaaggtca gaaatttcat agggccagat tactaaaatg gttattattatttttttgtt
115441 ttcaagagct tatgttagtt atctagtata gagaagtcta ccatagagatccctttgttc
115501 tgagtactgg actttttcac ttaccaaaac tctcctactc tatacgttcttcaccgtgat
115561 aatccaagaa gtctgaatcc tccccatggc tctcccctgt ttccatccccagtcggtggg
115621 tttcccacag gtctccagtg tgctttggaa gtaggaactc ctaacagattcacagtttga
115681 acatggtagt cctctgagct gttcagtatt ttaaatctct ctgcagttagttataatcat
115741 tcaactcttt tagtcattct tctaatgtca gtatagataa ctaaaagattgtaatattag
115801 aagacctatt tcccagagac cacaaagaca atctcatgga agtcccactgtagtaaatag
115861 agtctatttt ctacccagca tctggtagag taattcagac atgtgttttgacagtttgcc
115921 tgaaagtaac ttgacaaata attttactaa agaatcctag aaagtcaatggcaacatttt
115981 gttcattcta agttgttcaa gccacgtcct tagatgtggt tgattcaaatttcttcagaa
116041 ctggaaaagc acaagagaat tagtattcca gtaataagga atcatggattgtggcagtct
116101 ttttaaaaca taaactagtt tagcacataa gtggtggcct agtacattttaaagtggagt
116161 ccaagggaag tttcttgaat tgctgtagtt cttatggtgt tctgctgaagccgtgtagat
116221 cttatggtgt tctgctgaag ccgtgtagat attgatcatg ctgcctcccaccaccacccc
116281 cttcattcca gatctgctca aagacaactt agaaggtcct atcctggtctcctgtctgaa
116341 acatatactt tctctcctcc cgcccccagc ctgcccatac tattccaatccttctctacc
116401 tattattcct ttgttttgtt ttcaatataa aaatcttatc tatttctttatacgttaatc
116461 atctatcact ccccacacac tacaatgtgt gcattcattc cctgagtaactgaaacctag
116521 aggcccggga gtcatttttg aaacttcctt tccttggctt tctcctctaactgctcttcc
116581 aattcatcgg ctggatttga ctattctaat tccaaatctg tctggaactcgtgtacctct
116641 cgcagtgtcc actgctgttg ttctggtctg gggcacaatc gacactcatgctcaccgaac
116701 tgcagcagcc cccttcctgc tgcttatttt gaccacacct ctttttgaacctattctgta
116761 caaaggagct ggaaagagtc agtaaaaata cagagcatag tgttcattgccttgcttgga
116821 caggacctgc catatgtgtc ttctctatag tattggctga atgcataaacagcgagaaat
116881 aaatgtgtag agagtaaatt gatagaaagc tgccctcagt catctcccatggagagggct
116941 agtgatgact ggcgaaggtc acagagctac tatgtgttag attttggactaaaatccagt
117001 ttttctgaga acggtcaaga gtttatttat agaaaacatg ctgctttatctcttaattcc
117061 ttctcactcc ctgcaaatta gtggcatttt agtttactta aatgcacaattatttttaat
117121 tttgattgaa aaattaatac tcatttactt ctgaaaacta tttctttaccgaagagcata
117181 gagaaataag ggagtaattt atcaacctac cataggtgga atttttactttcatctttat
117241 actttcttct tcattattgt tttttttaaa aaacgtaagt atgcatttatttttataatc
117301 aggaaatatg tgaagttata taaatgtgta atgaatttca ttactgggaactaactgctg
117361 gtgatatttt acacttgatt ttagccaaaa ggccgagaag cgatgctggtgatattctaa
117421 tgtactataa cttattctaa tatttcatgg gatttatttg caattagtgtgatataaatt
117481 tccataatgt atggaaagat atattagaag atgctaacca tgggcttaagaaagtagatt
117541 tcataatttg aaacacggcc cacacaatta ataaatataa gacatttggcactctacttc
117601 taatctcttg atttttttta tagcaactgt ctttaagaac cccagcatattcatggattt
117661 tttagaaacc taattatttc ctagaaaaat cctttgaaaa aggaaaattatatttgacag
117721 ttttctaaag attttctgtg cagaagttgt atctggatat acatataaagccctgaagta
117781 atctatacat tttatcgctg gtcttcagat atgttggcag agtcgctcgtgaaatatatg
117841 cttgaaatta atgtaattac tctgacattt gttattttaa taagcattcttagctaatac
117901 atagaggaat acattaaagg aactctaaca ccaaaattat cctttcttaattaaataaga
117961 aggactgcaa ttatttaaaa agtgtatgtc aaatctaagt tgccttcaaatgtaatttaa
118021 ttttctgtta cttacatttt aaaatggcca tagctttttt cgttgttcatctttcttaat
118081 tctttaggca ctacttaccc cccaactcca gcaaccaaaa ttaatcctaatttgcatcac
118141 aataatttaa aatagatcaa agaaccaatt tcatagccta attcaaaagcatcatgcgac
118201 caatatgtag tattaataaa acatatttct ggttttgcca atccaattttttttttaatt
118261 aagtgcttaa cacagtgccc agcacagaaa aagcacttga tacatgtttggtaatgtctt
118321 tgtgactgtc atttttacta atgttgtata ttggtactac taaagtctaatgggatgctt
118381 gtattatggt gtgataatat agttaggatg accacttgtc atggctggcctgtgagaatc
118441 ctgtttaata tctattgttc cagttttctc caacttaaca ttttagcactcaaaagtatg
118501 tgatgtggag gataaatttt atggtcgcca atcctttatt gtaaagaatcgtgatgcaaa
118561 ggctccagtg tagtcatcac tcatctcttg atttaggcat ctaagctatccaggcatcat
118621 catgggggtg agcagcctga atgacagtaa gctttccaag tatggggacatgcacttaag
118681 ataggtatag ttattccagt gccaatctcc tcttacctgc tgtatgtcaagaatcaggca
118741 acatttagga aatgaaacca caagtctttg tctctttttt taccctttatctcaaaatgg
118801 tttttacttg ggatttgttt ttttgttttt tgttttttgt ttttttttttgagacggagt
118861 gccgctctgt cgcccaggct ggagtgcagt ggcgcgacct cggctcactgcaagctctgc
118921 ctcccaggtt cacaccattc tcctgcctca cctcccgggt agctgggactacaggcgccc
118981 gccactacgc ctggctaatt ttttgtattt ttagtagaga cagggtttcactgtgttagc
119041 caggatgatc tcaatctcct gacctcatga tccacccgcc tcggcctcccaaagtgctgg
119101 gattacaggt gtgagccacg gtgcctggcc tttagttgag atttgattatgaatgaaaat
119161 gtaaagaaat ttgctagatg tgtccatctt ttcatgtggc agacaatatggactagatat
119221 atggtggtca aaattatgtt tgtgggtata gcctaatagc ctaaaccaatgacacttatg
119281 tggcagtttt atttatttat tttttctttt taagacaggg cctcactctgttgcccagtc
119341 tggaatgcag tggtgcaatc tcagctcact gaaacctccg cctcctgggttcaaatgatc
119401 ctcctgccta aacctcctga gtagctgaga ttacaggcat gagccaccatgcccaactaa
119461 tttttgtatt tttagtagag atggtgcttt accatgttgg ctaggcttgttttaactcct
119521 gacctcaagt gatccacctg ccttggcctc ccaaaatgct gggatagcaggcgtgagcca
119581 ctacgcccag cctcaccctg gactttatga caatgccaaa tatatgcactgtgtcaaaaa
119641 cagtcctctt cactgtcctc cagtagaaaa agctcaataa tgggtctacaaactcctgga
119701 tttagtccag gctatgtaat ttgtggaact tagtgccaaa agtagggtcctttgttcaaa
119761 aattattaag aatttccaga tggcaacagt ggaacagtca atgaagcacaggatccttct
119821 gtccccaagg tcctgaacaa ctgcagaaac cttgtgcccg tgcattcatccctccttctt
119881 ggatccttta cctgttgatc tccttcgttt tctttccaga caacaattatggacaactta
119941 ttattaatat atgtgagcca ctgtgttcac tatcggaaat aaaaatatgcttataaggta
120001 gtcccaaatc tttttttttt tttttttttt tttttgagag acagtctcgctctattgccc
120061 aggctggagt gcagtggtgc gatctcggct cactgcactc tccacctcccgggttcaagt
120121 gattctcctc ccgcagcctc ctgagtagct aggattacag gcgtgagccaccactcccgg
120181 ctaatttttt gtatttttag tagagacagg gtttcatgat agtggccaggctggtttcga
120241 actcctgacc tcatgatccg cctgccttgg cctcccaagg tgctgggattacaggagtga
120301 gccactgtgc ctggccccag atcttagatt ttggtgatta aggacttcacgaagtagatg
120361 aaataacacc cagaatttgg ctggtttatt ttctccttaa gatgctcagctgtgattttc
120421 tgtatattag tctcaagctg caaattctct attccaggat cttatgatctgtgtcctaac
120481 tacatattat agggccccag tggtccctat gcctctggtt ctattgtcatcacacacttc
120541 ctgtttcatt cctatagaca gatttattca tgactaggga acagattatgctagtaaagg
120601 tgttggttaa catgagttta aggcaagaac ttaaacgtaa atatctctagggattggaca
120661 ggcaatatgc cttaaatagt aaagctatca ggtagggatt gactgcatgcctgcagagga
120721 aactgctgcc tatttagcca cagaagatta ttgccatgta aaaatgtgagtatggtttgt
120781 cacatatttt taaagaaaag tcagaaatcc aaaaatttgt atgaaatttttaaacatttt
120841 atattgtcaa ttcaattttt aaaaagactc aatataggca gagaaaaataactacagccc
120901 aaggttaagc caagaagtat tgtttttcta ctttttcttc gtagtcagatttgttcagat
120961 ataattcaga tgtaataaat aaacccttta agttctatga gttttaacaaacacctacat
121021 tagtgtgaca atcactgtag acaagatata gaataattct ctcgtctcccctccaaaatt
121081 ctctcaagcc tctttgtggt taattctcct agctcctgac aatcgctaataaatttcctg
121141 tctatagttt tgccttttca agagtgtcaa ataaatggaa cactactgtatgtagccttt
121201 tgagacaggc ttctttcact gagcacaaat aatttgactt attcacgttgttatatgtat
121261 ttagattgtt tctatctaat tttcaaaggt tttttccttc ctttcttctcctttcctccc
121321 tccttccttc ctttcttttt ttcttcttcc tccttttatt ctgccttttttctctccttc
121381 caactttccc gcttttttag atatcacatg tacagaagta gattaatcttgatgtttatt
121441 tcataacata ctctcatttg ggcccatgca tggcttgtat ttcaatagctctattgagat
121501 aaaactcata tacattcaca tggagaaaca gccctgtgga gggaaagaaattgatatgca
121561 gtaaactaca catactcatt tacaacttga aaagtttgcc atatgtatacacaatgaaac
121621 catcaacact ttcaaggtaa taacatatct cagtttcctt gtgtctttatgttattcttc
121681 cctccttcca tctgatctgc tttgtgtcac tgcattttct agaattttatgtaaattaaa
121741 tcatatagca tgtgctcttt tttttgtctg gcttctttca tgcagcacaattattttgcc
121801 attcatatca gtttttgtgt gtatcaatag ttcattctgt attattacaaattagcattc
121861 aattacatga atacattgca atttattcat ttgtgaatgg acattgcattatttccagtt
121921 ttggctgtga caaagattca tgtggaagtc tgtataggga catatgctttcatttctctt
121981 gggtaaatgt cttagagtag aatgcctaag tcatatggta gatgtatgtttaacttttaa
122041 agaaattgcc aaattgttgt ccaaagtgtg taccatttta cattcctggcagcagtgtat
122101 gagagttcta gttcttcacc atcccccttc caacacttgc tatagtcagtcttgcaattt
122161 tagccatttt aataaatgtg tagtgatatc tcactgttgt tttaatttgcatttccctag
122221 tgtctagtta tgttgtgtct ttacttttgt ttatttgcta tcattatcttccttggtcaa
122281 atatctgttt aataattgat acatttttta ttggactgtt tgttttcttattagtaactt
122341 tggagagtgc tatatatatt ctggatacaa atcctttaac aaatgtatgatttgcaaata
122401 ttttctccca gtctgtgatt gtcttttcat tctcctagca gtcttttgaagagcagatgc
122461 tcttaatttt ataaagttca ctttatgttt ttttttattt tgtggattggacatttggtg
122521 ttatatctaa aaaaaaatct gcctaaccca tagccttatg tgttttcttctagaagtttt
122581 atagttttag gttttacatt tgggtctatg gtccattttg agttaatttttgtatatggt
122641 ataagatgca gattgaagat ttttttttaa tatgtggaaa actgattgttccagcactat
122701 ttattgaaaa gactaatttc tccattaaat tgtctttgta cctttgttgtgaatcatttg
122761 cctatatatg tgtgagtcta tttctgaatt ctcttttctg tttcagtgattcatctatgt
122821 tgatgccaat gctacactgt cctgataact gtagttaata aagtcttaaagttaggtagt
122881 aaaagtctgc tattttcttc cttttcaagg ttgcattttc ctattccaagtaatttgcat
122941 taatcaaaaa gtacatggaa aatgtgtatt ataacaaaag gtatggaattttaaaatttt
123001 caaaattctt ttgcatcaaa gtaaatgtgt actaacttgt tataatatgtgtgaacagga
123061 gctagtttga ggcactaaaa aggataaatc atcaatttaa aaacagcccctatcagagca
123121 acatgaattc tgataaaatt gaagcaagaa caaatatcaa atttatcgtgaagcgtgggt
123181 gaaaaaaggg tgaaatcatt gatgctttat gaaaaattta tggggaaaatgtcacattat
123241 caaacagata actcatttta agaacagatg atatgatgtt gaagtcgaagcccacagcag
123301 cagaccatcc acattaattg ataggaaaaa aattcatctt gtttgtgtcttaattgaaga
123361 gcactgatga ttaacagcac aagtaatagc cacaaccata tacacctcaactggctcagc
123421 ttacacaatt ctgactgaaa aattaaaatt ggccaaagtt tccactctatgggtgccaaa
123481 accattgtgc ccagatcagc tgcaggcaag agtagagctt ttgacggaaattttaaacaa
123541 gtgggatcaa ggtccagaaa gatttcttaa aagaacatta ataggagatgaaacatggat
123601 tatcagtatg accctgaagc caaagcacaa tcaaaacaat ggctaccaagaggtggaagt
123661 ggcccagtca aaataagagc agaccagtca agagcaaaga tcatggcaacagttttttgg
123721 atgttcaagg cacttttctt gactttctgg agggtcaaag aacaataatatctctcatta
123781 tgggagtgtt ttgagaaagt caaagcgtta gcagaaaaac gtctggcaaagcctcaccac
123841 agagtccttc tccaccatga caatgttcct gttcattgtc acgaaacaagctctcacgaa
123901 ataaagctct aattttgcaa gaatttcaat gggaaatcat taggcagccaccttacagtc
123961 ttgatttggt ttcttctgac tttttgtttt ctaatcttaa aataatctttaaggggcacc
124021 catttttcct tagttaataa tgtaaaaaag actgcattga cataattcaattcccagggt
124081 cttcatttct taaggaatgg actatttggc cggtatcatt gcttacaaaagtgtcttaaa
124141 cttgatggag cttatattga gaaataaagt ttatattttt cattttaatcttttaattat
124201 atttttccac aaaatttttg aagtcctctc acatatataa atttttggaatcagcttatc
124261 aagtcatgta catttactgc tatatcacac tctgttttgt gaatattccaaaattatagt
124321 ctatgattta tattgttgtg actattgcat aatttacata tcaatgtactgatgatcata
124381 ttttgcaata tttttgttat tgttattcta ttatgaacag tgctactaatataaatagta
124441 tttgccacct catacacagg tgcaagttta ttgtaatagt cttagtattaaattttctga
124501 gtcatagttt agcaaaagct caacttttca caggatattg ctggattgttctccaaagta
124561 gctaagttat actcctatta gccgtatatg agagattcta atcatcttcattcttcaaca
124621 tttactattt tcagacttac taattttgcc agaaaaaata catgacaattcatacccgta
124681 cctgtagtgg tcttgatttc catttactca gaagacattg gacttttcttcttatgttta
124741 tgggctatat tttcccttct tttatgatat tactgttcat gtttttgctcatcttattgg
124801 gttatgggcc attttatttt atttttattt tttatttatt tatttttttttgagatggag
124861 tctcgccccg tcctgcagac tggagtgcag tggcactatc tcgactcactgcaacctcca
124921 atgggccatt ttatatccta acatatgaag tatctgttca aatcttttaccatttttttc
124981 ctgtaggtgt gcttgtcctt ttcttgttat aataaaacag ttctttatttttgatactaa
125041 tcttttagaa agtgttctgt tgggctgggc atggtggttc atgcctgtaatcccactctg
125101 ggaggctgag gtgggtggat tacctgaggt caggagttcg agaccaacctggccaacatg
125161 gtgaaactcc atctctactg aaaatacaaa aattagcccg gtgtggtggcgggtgcctgt
125221 aatcccagct actcgggagg ctgaggcagg aaaattgctt gaacccaggaggtggaggtt
125281 gcagtgagct gagagcatgc cactgcactc tagcctgggt gacagagtgagactccatct
125341 caaaaaaaaa aaaaaaaaag agagagaaaa gaaaatgctc tgtcagtggcaaatatctct
125401 tacttttttt ttagttttct ttgaaacctc ttttaatgaa tagaaatttttttattttaa
125461 tgtagtttaa ttcatctatt tttctttttt aattgtcttc agtttctttagtcttgtttt
125521 cataatcttc tggatatgag tcttgcaaaa catcttttgt taattttctcatggtttttg
125581 ttataatagt atttagagtt attttatata tttatggtta atataaatcaaattgcatgt
125641 tgttcttgct ctaaattaca gattcaataa tttgcaacaa aaccttatctctttgtaagt
125701 ccttaagtta attaagtact ctggatatct tcacatataa atacttgtatcagctgtctt
125761 ctctcttact actccaatta aaatccagta tctagaatag ggaaaaaccaggtgaacatc
125821 acccttacag agatttattt taagacataa tttagggtgt gctccatactgccttggcta
125881 tgtactagtc tatatattct agaagggtca tatatgtgca caaattgatttgtgtagcca
125941 aaagctgctc cagtataaat gtgccaccag gatccatttc aaaacattgcttcctcttgc
126001 caaggttagt gcagctatgc ttgctatcac tcaagtaacc agagaatgccagcgtccgta
126061 ctctcaaaaa gacagccttt tctgcaccat tacaattggt gtcttttgtccctttctttt
126121 cactgatgga aatctttttt atcattccaa tcaaagatca ctaccttcctaggagaagtt
126181 tcaatagaaa gaaaaaaatg ttatacttcc tcagaaaaat agcactttcttcatatagca
126241 agttttactt tcagaaaagt tgagaaaata aatactatgc ccccaggtttcccgttattg
126301 gagattgatt gctatgttga atgtgctata gctttgctgc ttaaacccaaacgccaagtg
126361 caggagtatc ttctttacta acgcatttaa tttaccaagc acacttagtggctggtattt
126421 cttacctttc taagggtgca ctcacttaca ctgccctcaa tatatgtaattaggataaaa
126481 ccatagaatg gaaggcatta aaaatgaggc aggaaagcac aggcagagtgggatgaagcc
126541 agctttgctc tgaataggac ttatatgatc agtttagttt tattccaaacatgaacccca
126601 aattcaaccc ctttgacctg agtactccgt cccttaaatg gcaaactaaacattcgtgaa
126661 aatttaatgg tgaggaaatg agtaccttct taagtttcag atggtgaaatggcaccaggg
126721 gagcactttc agtggcaggc agaagtgtgt ggatgtgcta gatcaaacctgaaatatttg
126781 ttccttcatc ctgcagtccc tctccaaact agccagccac tgagaccttctgacaggaca
126841 cccccaggat gtcacccaaa aaaggtattt acaaaatcaa gactgtctgtaggacactat
126901 gtctttctga gaggtataaa ggtatttgaa aactttggaa agtttgttttacaatttttg
126961 ttccctcttt tggggctttc cctttttcat ttttttctgt gggtagtttccctttgtttc
127021 ctgagaaatt gagaagggtt taatatctct ccaccttctt ctcttttatggatgaatgat
127081 ttcaccaact ggtaagtgct aaaactgacc tcgctttcac tcagaaagacaatggaggaa
127141 aggaaaatgc actgagattt cagcatagca actcaaatgc gggctttattccacagcagt
127201 gacctattgt cagattggtg tgtgagacag tttttgaaag gggatgtgttctgcttccgt
127261 ttatgagtta agcaaagttc taaattaagt tgagaagagg aagcaggtaaagtcagggat
127321 agcagagaaa ggagacatca aaccctattg ttgtaggata tttatgtgaaggaatgagca
127381 acgtgataaa acacattttt gcttgctgtg acttgccata gggtgcattttcagtactgt
127441 gtggataatg tgtggcatgt tcattcatca gtcattctgt gacatttatgtagcttacac
127501 ttggatctat tttcaacaac atttcagttc cctaaagaca aactggcagaattttcaaat
127561 aggaaaaacc tggacacaca catttgcttt tctgtataga ctgtctagtccagataatct
127621 tgctatcagt cattttgtta gcttactcat ttaatcttag aatggaaagtggaaacagag
127681 acctcattta gagataatct agtaaagcca tccagcttca ggctcatatcttgggaatct
127741 gagcagtacc ctatttaata tgctcatttt attaacttta aacacctggagaacatcatt
127801 attgagaagg tcattgcttt tgaaaaaaca aaaacaaaac aaccacttcttatgaggctc
127861 tacacatctt tccaaagaag ctattggaaa tggcccaaac tttcatattaactcttaaca
127921 gggtggcgtg gtttttcatt agtaagaaca ggattcaaat cttatggaagatggtagatt
127981 tcaacacctt agcatttttc tcaaccctgg gatcttcaag ttcctcaggctatttaggta
128041 gttatagtgc tggcaaactt tttaagtgcc cagtagtttt tacaaaaacttgtaataaat
128101 ctgctcaggc tatcttaatt gccaaccatc tcattaagca agtcaaattagaatggatta
128161 ttcctgctgt ttattagtgc tgcatattat ttatcattta ttaaccttattgtgctcaca
128221 tagcaggtat tttaaagttt aacagcttta ttttaattat gaatgtaatatatgctgttg
128281 cagaaaatat gtaaacttta gagaaaatgt actaaatgat gcactgatgaaaatacagaa
128341 tcccaccaca aaaatattat tatcaacatt tgggtattct cttccaaactttttatatga
128401 gagttatgtt tggtttatac ataataaaat gggtaaaaat caataaatagaaagcaaatg
128461 tttttaaggc agtacttggg cttcataaga atggaaaaaa atgatagacttgcctggtgt
128521 ggtttgcata atgtcacaga atcataacaa tagctccatt attgagtgtctattatgtgc
128581 caggttctgt acaatgttca gtgatgcgtc actgtgatga ctagaggtaaaggaaagata
128641 agtgatgcct tactatgatg acttccaaca agctatgaag ggacagaacaagcctttttt
128701 tttaactttt attttaggct tgggagtacg tatgaaagtt tgttacataggtaaacatgt
128761 gtcacagggg tttgttgtgc atattatttc acacccaggt acctatgtccagaacccaat
128821 agtttagttt tcttttctcc tcccctccct cattctatcc tcccccctcacatagacccc
128881 agggtctgtt gtttccttct ttgttttcat aagttcttat cattatcatacttataaatg
128941 agaacgtggt atttggttgt ctgtttctgc attagttggc taaggataatgtcttccagc
129001 tccatccacg ttcccacata agatataatc tcgttctttt tttatggctgcatggtattt
129061 catggtgtat tttatatata tagatatata gatatatata taaatatatatagatatata
129121 tataaatata tataggtata tatatgtcac atatatatat cacatatacaaggatatgtc
129181 ctctagctcc atccatgttc ccacataaga cataatctcg ttcttgttttatggctgcgt
129241 ggtatttcat ggtgtatttt atatatatat atctatataa aaatatatagatatatatat
129301 cacatatata tagcacatgt atctatatca catatatata tatatcacattttctttatc
129361 cagttgggac agaacaagtc aactggcaag tccattgctc agcttgttgaaatactctgc
129421 acagaatgca aggaaaaact gttttcatga ggtagcccat gaagcgatgaagcaaggcaa
129481 atttatctgc ctggataacc tcctgtatgc tgttttcact ccatggagagtcaacacaac
129541 agacttctga gttgtattat cgagctcctt caacagggca ttgctgtaagatcctagatc
129601 ccacactcca tggtgtgatg ttttagccaa gtctggaagt agcacaggccctaaaatctc
129661 atgattgcag gttgtcaact ctgctgtagg cttgccactt caagggcaagtggttggttg
129721 gggctgggat ttgggcagag ccatagaaag aaagggaaca ttcaagggaatttgatgatg
129781 tgcatgatgt ctctgtctga tacaaaaaga aaaaaaaact ctaaaaacatttgatacata
129841 gaaatactag tatttggtga gattgaatgt gggaagatga gggataagaaggtattaaga
129901 atgactccca agtttctgac ttggtcagtt gagtagaagg gaaatttttatttttatttt
129961 tatttttaaa atttcagtaa gtttttaggg aacaggtggt gtttggttacatgaataagt
130021 tctttagtgg tgatttctga gattttggtg cacctatcac ctaagcagggtacactatgc
130081 ccaatgtgta gtctcttatc cctcaccccc catcctttcc cttgactccccaaagtccat
130141 tgtaacattc ttatgccttt gtgtcctcat aatttagctc ccaattgtgagtgagaacat
130201 atgatgtttg gttttccact cccgagttgc ttcacttaca ataatagtctccaattcatg
130261 ccaacatcta ttattttttg attttttgat catgaccatt gttgtaggagggaggtggta
130321 tcccattatg gttttgattt gtatttccct gataattagt gatgctgaacatctttccat
130381 atacttgttg gccatttgta tatctgagta gaaggtaatt ctaataaataaaacaggaag
130441 gcagcagaaa gaggtttgtt tgggatatgg cttgattatt tgcaagatatttgctgtagc
130501 ttaggagaaa ggtggatgtt ggtgatactg attttgtcat tatctgtgagttaaagtttc
130561 taaaatcacg tggcttccta gggaaagcat atagaatgac aagggaagatggctagatgg
130621 ctagtaatgg caccctgaac aacttcagca tttagaggtg ggtggaggaggataagccca
130681 tggaagaaac agaaaggatg ggccagcgag atgagaggag aagctaagggagtagacagt
130741 taccagaggg aaggtgggat cagttaagaa ccttagtatg ttgcaaagaaataacctgca
130801 atgcggacca acccggggaa cgtctgtaaa aatgatgaca attcttaattgtaatttaaa
130861 atgtaattgt attgagagct ctctctgtct ttgtctcatc ataatttgaagcagattaac
130921 tacatattag ctagaaaaag ccctttgaaa ttttccttca atgtatcaatagattctatg
130981 actttttgta agtagaaact gcctattggt aaaatagcac ttaattgagataatgcttgt
131041 gaaagccatt tctaaacttt gaattgacat acaaaataaa ggtggcaatcatcaccatgt
131101 tgctatactg tctttggcca tataaaattt ttttcaacaa tacaaagataagccttgtac
131161 aaattcttca aaattctaaa tttgtggtac ttgaataatg ttttactatatataaagatg
131221 aatagatagc atttcctaca ataaataaat aatttatata tcaatgtgttgggattataa
131281 attctcatag aaattcactt tattaattca ttcattcatc tgatcacagttcattcagca
131341 aataatttgt tttgttcttt ttaagtgctc tgggaagaag gtattgtgacagagtccctt
131401 ctctcaaagc gtttatagat tcatgtgttt ggggaaagta cagaacaattattgaaataa
131461 aaccagagtc aggcacattg ctatgccagc tataaagagc ctatgaaaattaggaacatt
131521 gacacatttg ttcctaacct ggtttgtgct ttcaggattc ctctgaagtggcagcactcc
131581 ttgggtttga aatgttcgtc agtaatgact gatggacatc aacaggtgaatagacacaca
131641 aaaaacctat gaaacttaca taccataggt tactattcaa caataaaaagaaaaactgtt
131701 gatacatcta acaatgtaga tgaatctcaa aagcattatg ctattcctttggctgataaa
131761 atggtgacac tcctttattt ctctttcttt catcccactt ttaaaatcagccttagtata
131821 ctttaggcac aatatactat atacatttaa aatgacaatt tgacaagttttgacaaatgt
131881 atatacatta taaaaatcat gataaagatt tccgccgcct caaaatgtttcctcatgcct
131941 tcttggaata aatccacaca ttccttcctt ctctacaccc caccacccatatactctacc
132001 tctagaccca agcaattgct agtctgcttt ttgtcagcgt aaattagtttgcattttcta
132061 gaatttcata ttaatggaaa tgtacagtaa gtactctttt gtgcctgacttcttacattt
132121 agtatagtgc ttttaagatt tatccaaatt gttgggtgta tcaataatttgtttcttttt
132181 attgctgagt agtattctat tgtatacgtg gttcacagtt tatccattcaccagttaatg
132241 gacattccag ttgttttata tttggggctg ttatgaataa agctgatgtgaacatttgaa
132301 tagaagtctg ttgtgaatgt ttggattgga attgctgggt tgtacagtaagtgtttgatt
132361 aacttcataa gaaactgcca aatgattttc caaagtggct acatataattttgcattttc
132421 accagcagtg tatgagattt ccagttgatc ctcatcctca ttcaaaacctggaattaaga
132481 gtgaatcttt taaattttag ccttttgaga aaatgtgtag tggtacttcattgtagtttt
132541 agttcgcact tctctaatga ctaatgatgt ttaacatgct tttatatcttcttttgtctc
132601 catctattct ttgttcttca ttctcttttc ttcctttaga gtaagtattttttattttat
132661 tccattttca ctattggtat attatctata aattctttgt tgttgttccattttagtggg
132721 tttacaatat aaatctttaa cttatcacag tctgtcatca aataatggtataccccttac
132781 atatgtttta ggaaccttac agtggtaaaa atatcagttc cccatcctgtacttgttgct
132841 attgttttca tgcattttat tctgtatata ttataaactc tacaatctatcattattact
132901 ttttgtttaa atattaaatt ctttaaaaga gatttttaaa aataagaaaatagtctttca
132961 tattttctca tgtatttgcc atttttattg tttttttttt cttccatatttgagatccaa
133021 atttctatct ggtatacttt tccttctgcc tgaataacta cctttagtatttttttgtag
133081 tacagatctg ttggcaatga ttatctgaac ttctgtatgt ctgaaaaagcctttagctaa
133141 tttttgaaag ttttttgatg gacatatgat atggtttggc cctgtgtctccatctaaatc
133201 ttatcttgaa ttgtaatccc catgatcccc atgtgtcaag ggtgggaccaggtggaggta
133261 attggatcat gagggccgtt cgccccatgc tgttctccta ataatgagtgagtctcatga
133321 gatccgatgg ttttataagt gtctgacatt tcccctgctt gcacttctcctttctgccac
133381 cttgtgaagc aggtgcctgt ttccccttca ccttctgcca tgattgtaagtttcatgagg
133441 tctccccagc cttgctgaac tgttagtcaa ttaaacctct ttcctttataaattacccag
133501 tctcaggtat ttcttcatag cagcatgaga atggactaac acggtacatacaattacagg
133561 ttgctagtcc cttttttccc ttcagtgctt taaggatttc actcttccatagtttctgat
133621 gagtagtctg accattccta actttgtgcc attattttct catttttttctgactctccc
133681 ttctgggact ccaattacaa atatcccaga cttcctaact ttggcaggtcaagagatcga
133741 gaccatcctg gtcaacatgg tgaaacccag tctctactaa atatacaaaaaattagccag
133801 gcatggtggt gggcgcctgt agtcccagct acttgtaagg ctgaggcaggagaatggctt
133861 gaacccggga gggggagcct gcagtgagct gagatcgcgc cactgcactccagcccgggc
133921 gacagaccga gaatccgtat caaaaaaaaa aaatcattca aaagattactgatgcttgtt
133981 tcattttttt ttaatttttc aactggtaat taatttatta aaatagttgacttatacgtc
134041 tacaatggtg acttccatct caactcctgg ctcaatactg atggaagtaatctgcttaac
134101 aatctcagaa ggactgagca agtcaatgag tcgcttgtgg attctcatctggaaatgatc
134161 ccatggctta gaaccttcac cacatggagt tttttcttgt agtgattctcaaagtcttag
134221 taggcatttg aactggtctt ttcactttga gattcttttc ctttgctcctctgatcaagt
134281 cagcacacac cttcgccagg gattttacat tgcagcttgt tagagtgattcgaattcggt
134341 gaattgccat cttcggctcc gtgggtgttt ttccggtatc cttaaaagccatcactgctg
134401 cgcggcttcc tgacctactt gttccggcaa gagtgaacag tggtgagtcaggagcaggtg
134461 cgggcggatc agagctccac aacacctacg accacctctt cttcaaagaggtgtttcatg
134521 ttttaaaatc ttaatttcct tctgtttcat tttggataaa atctgtcttcaagtttggtg
134581 cctttttttt tgggccaata tctaatctaa agttcatcct atccagtatgtttctcattt
134641 caaatattgt attttctatc tgcagagttt gatttgtatt tgaaaacgttttttaatctt
134701 tctcattgtc ttaaacattt ggagtatact tataataatt gttttactgttgttatctgt
134761 tacttctatc atctatgaaa ttactatatc tgtttctatt gattgatttgattactattc
134821 tggttgggag gcaatatttt ccctacttct ttgcttactt ggtaatttttttatcaatga
134881 aaatttataa aagtgaactt catttacaat tggatataat gaattttacatttttgtgtc
134941 ctggattttt ctgtattcct ttaaatattg ttggatttct tttttttcccccctccggga
135001 tgcagataag tttcttggaa ttagctggat gcttttgaga tttgcttttaagatttgtta
135061 gggtgaattc agagcagggc tactttgatc taggaaatag ccctctgaagggtctcatgt
135121 tctgtgagat aggaggtctt tctcctctga ctggttggta gcctaagctattcctgattc
135181 ttgtaaggtc tggacactgt tctgcatact cttttctgat agttctttccctggccttag
135241 tagttaccac acatctatgc acatagcggt attcagccaa agtttgaaaggattcaaaga
135301 tctccagagc tctctctgta tcactgtttc tgttattcta tcccacaaattctaagtgtg
135361 tgaaactccc tgaaatcaga actatgtctc ctcaactcag tgagaccacaagccactgtt
135421 tgggtttccc ctgcccatgt tgcagcctag aaactctcct caggcaaaaagatcaggcaa
135481 catcggggtc atctcatttc cttccctttc agagatcact gtaattgcctattgaacaat
135541 gcctgaagaa agatgtttca tatattttgt ctggctttct agttgcttaaggtaagaagg
135601 taaatgcatt cctagttact gcattgtggc tgggagcaga attccaatactgtttttttt
135661 ataatatgct tttacttaat tatttgagga ttccctttag ttatcataattttacatgat
135721 gtaaacaggt aaatgagaat atcttcaaaa tatatttttc agttttggggtggttctctc
135781 agttctggtt tttgccaaat ataatagatt tttagtatct gagttccatatgacaaaatt
135841 tataaatctt gggtgtatcc atatggtatg ttataatcgg aaaagatagatgaaattccg
135901 cttttgtcta atgtctttat aggtcttgga gaaacttgaa gaagggttgtaaagtccata
135961 actttacaat gagacaaaat taaaagaatc caagccaaaa ttgtcctagacaatgaaaag
136021 tatcgctatg cagaagccaa atctcttaag ctcctccacc atatcagtcatgacacagtc
136081 tatagtttaa caattgtttc aatttggaaa ttaattttta gtactaatttaaatatttca
136141 tattagtata tgagaattct tccttctgtt caggctgtgg tatggggaaaagtcagttcc
136201 catcaatgca gattcatatc taccagcaca gtgattaaat tatcctcatatcctcttgtg
136261 tttgaacaag ctgtgtactt ttaattttaa tggatttaac tcaatattcaatatatgttg
136321 attactgaat acaacaaaaa gtgtaataga cactccttga gaagctcataatctatttgg
136381 gcagatggaa caaatactta gaaaaattga aaggtagttt aggaccacagtaaaaaaaaa
136441 ttgggggtgc aggatataaa gtatcaattg aattgtagaa gcaatatatactgtgtattt
136501 tttcacctgg gtgagagggt gagactccgt ctaaaaaaaa aaaaaaaactatggttgttc
136561 accataacta aacatttaat ctctttcagt ctatcttact catctacaaaatggagataa
136621 tacctgtttt gcagtgcagg ccctgacata cgggtagagt tccataaatcctagcttcta
136681 ttccttaact cttttaactc ttttcttcct tccttctttc tagctaatttttaactctct
136741 atcctagaca acttttgcta aacgtgtata acatgtagta cctacgcataggaatatgtt
136801 ttatagaaca gaattattga aaacagcttc ttacatttct gttattttttcaaaagcaag
136861 aattcatgta ttccttctga gccaagtaca tgcaataaaa agtaagagagattcagaaat
136921 tctgatgatt attctcccaa gaagagtgct tgctagagtg agggtcttgcagacacagaa
136981 ggagctgatg gggtgaactg ctggggtgtt acaaaaggcc ttcgggaaaatacgtaatct
137041 aagtcaataa atcatagagt gaagattccc tcagggaaaa agggagtggttctgaagaac
137101 ttacaaattt ttccaggcaa tagccacaga tgctagcaca agggcattatggccacatag
137161 tgtgagcaaa agtgcttaac tttttgccct tcttctaata tttactctattagcccagac
137221 aacatgagat ccagaagcct catgatgagt ggagaggaaa tataaatcagaagaaatggt
137281 caaaaagatg cctatattca cttccgcact taggtctcca agcctcagttcctggcatga
137341 gtaggtagag gagaggagct tggaatagga tgtgagatta cagttttaatatagactgga
137401 ctggatattt gaatacctga aaatgaatct gaattctcaa aatgaggtggttcctgcaac
137461 tgaaaataac aagaaagcta caggatcttc tgccatgtta tccaggggtggaaaagtgaa
137521 attcagtgga gccaggttaa agatggagtt tgggccggga gtggtggttcatgcctataa
137581 tcccagaact ttgagaggcc aaggtgggca gattacttga ggccaggatatcaagaccag
137641 cctggccaac atggtgaaac cccatctcta ctaaaaataa aaaattagccaggtgtggtg
137701 gcatgtgcct gtagtcccag ctactggggt gggtgaggca tgagaatcacttgaacctgg
137761 aagggggagc ctgtggtgag tcaagattgc accactgcac tcccgcctgggcaacagagc
137821 aagaccctgt gtgaccttgt gtccaaaaac agacaaacaa acaaataccatgtggagttt
137881 gtttactctt taaacaaata tccttcatgt gttgaactga actataattatagttagtag
137941 ggcacatagc aggttttaat aagatatcta gttcttcctc ttaaggtaactcgttagaac
138001 ttttatgaga aagaactaaa gaatttctaa tggggcagct aatccactcttttgtgcact
138061 ctgttctgct gatgatctga tgttagtcgg ggtttctgtt tgagattcctgagccttaac
138121 tgctgatgac agagttcaaa atcattgctt tctaactttg agaatgactgcctaatatga
138181 catcattttc tacccctgag tgctaatagt ctaccttatt cctcctgcctgtccttctcc
138241 ttgaggagga ggatcatcaa tgcactgtgt ggattgaagt ggcttcatacccttttgatg
138301 ttaatgttct cctttgctta aagtgtgaac tgaatatgga tccctcatttatgaagcacc
138361 atgacacttc ctgggtaatg aacaattaaa cagacttctc agcaatagtgactatttttc
138421 tgatttttca cttcatggac aatattgtat gcaagttaaa tttgcaactagcttgaggct
138481 tcacacatgg tgagtttgag aaattgaatt ctctacctca aatgtatttccttttccttg
138541 aactctacat tcaggtcagc tgtccagttc ttaaacaaca ggttttggagaggcaatgag
138601 taataaaata gcattttctc cttcaattct atctgcattt gaaaaaaataaccttttatt
138661 tttgattcaa agaagagagg agttttcttg tctttctaca tctgttccaactcctccaaa
138721 tgcacaaaaa ttttttcaga gcattccaga gtttctcaga ctgcacatagaagattttgc
138781 atatagatac atcttggcca taataacctt ctactgaatt agtagaaaatagatgtattc
138841 taggttttca tatctttatg gcaatatgaa tagacaaggc tcttcttgcaaaaatatctc
138901 ctgaactgtg cgggagatgc ttggaagacc cagtcaaaat tacgaagtatcccaagtttg
138961 tatcctcctg tggcttcccc gtattacaat aatgtcattc tgatccaggttccagtactc
139021 tcaagccctt gtccttccct tttcatttta gcttgcattc atccaagtatttggatggaa
139081 attatcaata ccttatacga gaacgtatgg gaggctgagg cgggcggatcacgaggtcag
139141 gagatcgaga ccatcctggc taacacagtt aaaccctgtc tctaccagaaaaatacaaaa
139201 aattagccat gcatggtggc acgcgcctgt agtcccagct acttgggaggctgaggcagg
139261 agaatcgctt gaacctggga ggcagaggtt gcagtgagcc aagatcacgccaccgcactc
139321 cagcctgggt gacagagcga gactcatctc aaaaacaaac aaacaaaaagaatgtaaatg
139381 attgggagtt aaaattatgc ttttcagttt tcagccatgg atcatgttttcttgccttgc
139441 ctgattccta gagtctcact ccatgatgtt tcctctttat tataaagattagatggcttt
139501 gcattgctgc catgtggcat ttatacttct caagcagctg tgtcatcttattctaccgtt
139561 taaacttagt tttactttaa gtccacatct aaactgtttg cctgcatgcccagcactttt
139621 tccaccctct acattttatt tgactggagc aatcacctta gcctctctaggtctttgctt
139681 atcatcactc tgctcattct tcaagcctca cttgattact gcctcctctgtgttgctttc
139741 ctggatttcc tcagtaagac atagtttctc cctttcatac ttctgtggtattaagtatgc
139801 accagttaca tgtgactcat ctccaagtgc tttggcatgg agatattatttatgttcctt
139861 atatgactac tgaccacttt tttctagact aaatattgaa acacttggccagataatttt
139921 gcttaatttt gagtttcctt ttatactttt taaaacaaat ttttgaaattaaattacatt
139981 ttgttaggtt gcaaatctga aaaagtccaa ggatgaggtg agtttgttgtggtcagttgg
140041 gtagttgcta aactcatagc tggtttgtgt ctgctgacca gcacattgttagcctagaga
140101 aagtctacat ggggaaccag attatgatgc aagcgttgct tggagagcccttgatcaaga
140161 gcaaaacagg ttggtagact cgagggatag ttcagctagg tctgatggaacattccagtt
140221 ttgccaacag aaggaaaaac attggaaggg cttatcttcc ccaggatctggatctgttcc
140281 actgggtaac atttaataag cactaacatg gtctcttctt tcacttgccatttcctgtgc
140341 ttctttttcc aactactaca tctcctttga cacattttct ttttctttttcttttttttt
140401 ttttgagata gagtcttgct ctgtcaccca ggctggagta cagtggtacgatcttagctc
140461 accgcaacct ccacctcccc ggtccaagcg attctcctgc ctcagcctcctgaattgctg
140521 ggatcacaga tgtgcgccac cacactcagc aatttttttt ttttttttgtatttttagta
140581 gaggcagggt ttcaccatgt tggccaggct ggtctcgaac tcctgacctcaggtaatcca
140641 ctggcctcgg cgtcctagag tgctggcatt acaggtgtga gccactgtgcctggcctctt
140701 tttaagtgta tcaataccat cattttggct gcttattctg ccctgggagccattctgtct
140761 ctttaggaag tttttgcgtg tatcagatct catcttttat attttgatgtttaatagcat
140821 ttaaaggatt ttgttttgtg ttttttaaat gatttgaaaa caagtgtgctcactaattaa
140881 taaacagcag attcaaactt ttgttgcttt ttcaagaaaa aaatgaaaaattctgtaaca
140941 atatatctta gccataaaac acttgtaatc agcactcctc cagaaatttcaggatgtaag
141001 ttatcttaat gattatacta gaaaatcttg gaaagcaggg atatggctaactttttataa
141061 catgtatccc tactgtcaca acaagagtta agacttaata aatacagtcatgtgttgctt
141121 aacaactggg atatattctt gtaaccaccc aaggggttca ttttgcctgctacctggata
141181 cagccaattt atcaagaacc aggaattgca gtagagaaag ggtttaattcatacagagcc
141241 agctgaatgg gacactagag ttctattact gaagtcagtc tccctgaaaattcagagggt
141301 agggtttttc aaggatagtt tgaagggcca gggaatggtg ctgctgattggttggagata
141361 caatcatagg gatgtggaaa atggtcctca tgcatttctc aagtccactccttttcttag
141421 ttcctgctta gcggaggtgt tagaatttgc ttcttggtgg ggccacaggactggttggtg
141481 ggtccaggtg gggccaccag ttgtcagaaa tgcaaaaacc tgaaaagacatctcaaaaga
141541 ccaatcttag gttctgtaat agtgatgtta tttgcaggag taattggggaagttgcaaat
141601 cttgtggcta atttgttagt cctacaaagg cagcctagtc cccaggaaagaagggggttt
141661 atttaaggaa agggctgtta tcatctttgt ttcaaagtta aactataaactaagttcctc
141721 ccaaagttag ttggacctgt ccccaggaat ggacaagggc agcttggaggttagaaacaa
141781 gatggaatct gttagtttag atctctttca ctgtcataat tttgtcactgttaacgtttg
141841 caaaggtggt ttcactgtag actttataaa caccatatac ttagactatactaagtttat
141901 taaaaatatt tttctttctt tagtaacaaa ttaaccttag cttactataagttttttact
141961 ttttgaagtt tttaattttt ttgaactttt gactcttgta ataacagcataaaacacact
142021 ttgtacaact gtacaaacat attttcttta tatacttatt ctataagtgctttctatttt
142081 cattttttcc ctttaaactt tttaatttaa atgaagacag aaacacaataccctaggtct
142141 acacaggttc tggatcatca atatcattat ccaccacctc cacatcttgtcccactggaa
142201 gatcttcatg gacaataaca cgaagctctc gtctcctgtg ttaacaatgccttcttctgg
142261 aatacctcct gaaagacctg cctgaggctg ttttatagtt aatttccttttttacaagta
142321 gaaggagtac actctaaaat aacgattaag agtattgtac agtaaataaatacagcagta
142381 acagagtcgg ttattatcat tatcaagtat tatgtactat acctaattgtgctacatttt
142441 tgtatgcctg gcagtgcagt aggtgtgttt caccaggatc accacaaacatatgagtaat
142501 gtgttgatct atgacattac cagagctacc atgttgatat aaacaggagacagggaaata
142561 ctgggtagaa gagggcagtt ccctggcaaa agccttactc ccaagcctggaaacctgcag
142621 tcctaaatgg gaataggcat tcctgtttgt gcatccaaat gttgccttttggcctgccat
142681 gcccctctgt cctgtatcca tataaacccc aaatcccagg cttgatgagcagatgagcag
142741 acaaacagaa gagcagagga gcagaagagt ggtgctgcag agaaagagagaagagaagga
142801 gcatctgaat gtcaagagga gtttggatgg ggatggtcag agaggagatcagctgcagga
142861 cagccaaact ccaggggaag atcatctctc actccatccc ctttccagctccccacccat
142921 cctgctgaga gccacctcca tcacccagta aaatcctcac attcaccatccttcaagttc
142981 atgtgtgact tgattcttcc tggacactgg acaagaacct gggtaccaagagggcactga
143041 gctggttaac acttaagcca tctgcggatg gcggagctaa aagagcactgtagcacaccc
143101 actggggctt tgagagtcac aggcacacac ccctagatgc caccgtgggatgggaaccca
143161 aaagtgctcg ccctggctcc tgcacctatc tgtctacatg ctccctctcctataacaggc
143221 ttgcacagca gtgactgcgc aacagatgag ccacacccct tccacatgtctgcaaggggt
143281 atcagggaac tctccccttt caatgtcagt aggtaatagg aattttttagctcctttata
143341 atcttatgat accacctttg tgtatgtggt ctgtcattga ctgaagtgtcgttatgtggt
143401 acgtgactgt atttattgag tggatggtca attgtatgag gtacttgaataatgagtggt
143461 gtgaaccttg gttttatgac atcttctgag agctgctttc aggtgggtataagaagagat
143521 atttctagtc taggtcccca ctccttttct tagttcctgc ttagtggaggtgttagaaaa
143581 aaaggttgga ctctggcact attttcctcc attggttata tggactcaaagccataactt
143641 aaggaagaat gtctattttt agatttggtg actgatttag ataggttgctacagaaagtg
143701 gtacaaagat atttcacaca tagaatatca aatccagggt gctttagcactgcattccaa
143761 tggcctggga tggatgggtg gaagccctgg caagctgaaa taaaccagggcaagctcctc
143821 tttggaattc acaagtctga caactggtga ctcaggctct agtcaggagacctgaatgtt
143881 acgtctggca tcacgatacc ttagtttaca gagattaatc taacaggccttcagttagtt
143941 tgctttattt taaaattctg cttagctttt tgttgcctac taaatttctcctgatgtata
144001 tttagatgta ggtgaaggct gtagatgtat gcactaccaa caccagcttctgggagggaa
144061 cattttccca ctcacaagca agtgaacttt gctttctcca tgaagaagaatgacctgcat
144121 gatggctttc agaagtggag aacatggctc acagttccct ccacagttcctccatggcct
144181 ttggttgcat cttctctgaa tggaggagct tgggttatgt gaaaagcagagctaccagac
144241 tacataaatg ttttagtgag aaggcagcaa attaaaatat cagaaattttgaaaggaaag
144301 gtttataata gttagattta aaacatactt tgaggccagg cagcgtggcttacgccagta
144361 atcccagcac tttgggaggc caaggcggga ggattgcttg agggcaggtgttcgagacta
144421 gcctgcacta cataacaaga ccttgtcctg tctctattaa aaaaaaaaaaaggaaggaaa
144481 gggaagaaaa agtgctttaa tattcagagg catgagagat gcaatgagtaatataggacc
144541 ttctctaagg acactggggg agcactctac agaggtggtt ctaatctagcctggcaaatc
144601 tctgttccct tcatgccttg tacttccttc ttctttgtga ctttgctaatgttattcctt
144661 cctcttggac aaatttccta tactaaccaa aaggccccaa gacacagggggaaatgtggt
144721 aaatctgaga ctggaaggaa attaccatct aatgtcactc ttgtacagtataactattgt
144781 taatattatt gctggggtca ctcatttatt catatcacaa acactgactgagtgcctatt
144841 atttgccaag catgggcaat aaagagttga agaccaacaa agcccctgccttcccagaag
144901 cttatttgct tgtggggaaa ataaacagtg gatcaattaa caaataagtagataacataa
144961 tgtcacggcc aggcgtggtg gcctcatgct ggtaatccca gcactttggaagactgaggt
145021 gggaggatca cttaggccca ggagtttgag accagcctgg gcagcatagggaaatcccat
145081 ctctaccaaa acaaaacaaa acaaaacaaa acaaaacaaa acaaacaataaacgaaacac
145141 atggtggcgt gtgcctgtag tcccagctac tcaggaggct gaggtgggaggatcacttga
145201 gcccaggaca cagaggttgc agtgagccaa catctcccca ctgcactccagcccgggtga
145261 cagggtgaga ccctgtctca aaacaaacaa acaaacaaaa caaccaaaaaccaaaaaaag
145321 taatgtcaga tggtgactgt tttgaggaaa ataaagcagg gtaggggaactagtgataac
145381 tggtagattt gggtttctcc atctctggct gcttttgcat cctcagtaaggtgagagtgg
145441 caaaggaaat tccaggttga ctttcgggtt cagtgaattt tctaccccgtgtctcttcac
145501 tgccctttcc ctccccagaa cctctaaaat ctgatcctta gattctgcaatgtaagtcag
145561 cttccttctt cctggttgcc agctcactac attcttattc ctggataaaccaaaaatctc
145621 ttccttgttt tcatattttc aaaaagatgt agaaatctct cacctgctcatgttccttcc
145681 tttttgtctt gttggtatat atacctttta caattctttc actaccaaatgtagttggat
145741 attgggatgt agtcacaaca aacacataaa tacaattcac catttttaaatggacttatt
145801 catttagtct gcttaaaatt gagataataa cacacgcacc agttgggtttctctgagaac
145861 tctgggcatt tttaatcctg gcaattttta aattgcttag cagtaaaacagtcagacaac
145921 agcacctatt gttataaatc cctgcctctt cttacctcaa tgaggctatcctttctctct
145981 atcaattctg tcagcagaat taagaagagc cattgatttc cagtttgttcagcgtttttc
146041 ttcttaggat gggagtgatg acttctaacc tctttacatc tagagactcaatttaagtct
146101 acttctttca ttcagccttc tctcttcatt ttcagctgcc tggaatgtcttctttctctc
146161 agttcctatc tttgacatta aaaatcacag tacttagtta tattctacctcacaccaatc
146221 attttacttg ttaatatctt ttttcctagt tagattgtga cattttggaataaaagaaaa
146281 atatcctttt ttactttata gctctccaga tttcattaga ttagtatagattcgagtgcc
146341 ttttatatat caggcaatgc ctagtgtata atatttttac ttatgggttttagcatttaa
146401 cttatttaat gatcacaaca ttcctatgat gttatttgtt ttcataatttgttgaaatga
146461 aagctgatgg tcagaaaggt taaaaagttg tctggtcata atttttgaggaggcagagct
146521 aggttttgaa cgcaggtctg tctgattctg agaataatcc tgtgctccttcagctgaacc
146581 acacagcccc tcttagtgct ttgtctccat agacactaag tgtattcttgttgattgagt
146641 gaattaacga gtgaattatc tggagctctt tctgcttctg ttttcttctctgtacaatga
146701 ggatcatcac atgaacctga tctaagaata gaatagtcca actgagttcccttaatttgg
146761 taaccaagag agagtagagt taattaacta gaaccctttg ccatcacttctctctaaact
146821 tttcatcatt ttcctctaaa agtccggtcc tgagctctat tacaagatagaacattttag
146881 cctctatcga agagagcact attaatattt tatggcattg gctccttttttcctaatact
146941 gtgggattaa aataatgttt actaaattct ggatgttcga ttcctgttttttcatgatat
147001 tttataatcc aggccttctt catagagaca cagggctatg ttttataactgccagggtca
147061 agcaaagaac agcttgtgtg agatacttaa agaaatagct aagcagtaacttcagacctt
147121 ctgtatattt tcctcaaaat tttctctcag tttttgtctc cctacaactcatttttagaa
147181 aacaaaaaca taacacaatt ttgccctttt aaaagataat acagctgggtgcagtggctc
147241 acgcttgtaa tcccagcact ttgggaggct gaggtggggc agatcacctgaggtcaggag
147301 ttcaagacca gcctggccaa tatggtgaaa ccctgtctct actaaaaatacaaaaattag
147361 ctgggtgagg tggcggcagg cgcctgtaat cccagatacc cgggaagctgaggcaggagg
147421 atcgcttgaa cctgggaggc ggaggtagca gtgagctgga attgcaccactgcactccag
147481 cctgggcgaa agagtaagac tctatctaaa gaaaaaaaaa tgtactataataatttacaa
147541 agtacagaaa atatctaaag gaaaagaaat aacatctcac aacctcatcatctagatatg
147601 actgcaaaaa ttttggcata tttcatttca gcttttaatt aatttatttttgcagaagac
147661 atttatttca gatattctaa ctttataatc tgtagaattt taatgatatttttgtatgac
147721 atctatcata aacatttctg catgtcattg aaatatttat aaatgttatttttatttaaa
147781 caatgcataa ttgatataac ccttctctta aaattggtga tttcacatacctggggatga
147841 gccgatgtga aacaaaagag aaagggtaag agatagctag tctcttgactcatttttttt
147901 tttccatatg acttgaaaaa aagaacttat cttagagacc tctagaatagttagcacaaa
147961 tagatttctc aatgtggtta agatgaaata cagatactga atttactcttttatgtgaaa
148021 taaataaaaa ctggataaga tatatatagc aacagttttc aagacattatacctcagaca
148081 acaaaggata atgacctctg agagagggaa aacaaattag gtgagcctgtgattgcccca
148141 gtttactgcc tggagagaga ttccaggcca gggtgcagag agaagggttgcgaatggaaa
148201 ctattgctct ttctgagtta aggagagaga cctgaaagtc tgcaggtacaaagatagctg
148261 caattcatga gaaagagttc cagagaaaag aaaactgaac agagagtgagctctggattt
148321 ctgtagtgtt cctgctgact cttctgctga atcatgatca gtgcatgtgtgtggctggag
148381 aaagaacctc tgaaaaggtt tagagggaca aatccttaga atcacataggcctgggaata
148441 gctcctcttt ccaccagaaa gagtataaaa accatgaaat tcatgggacattaggtagag
148501 tacttagaag ggttttgctt cagcagtgag aaaaaattag tcctagaccaaatgttgctc
148561 tgatcctaac aaaacttaaa aaatgagacc ctaaaggata aaactgtttccaggtaactt
148621 aaatatatac cagaacaaag ccgaagacta taggaatatg aaaatatctagcagtcagta
148681 aggtaaaatt cataatgtct aatatgcaac caaatattac catgaatataaagaagcatg
148741 aaaataaata cccataattc caagaaaaat caattataca taattgccccatcaatgaca
148801 cagatgatgt aattagtaaa caaagagcta attataactg ccaactctagccattacaca
148861 tgttcaagtg gctagaggaa agatcaaatc acgacacaga agaaataaaaagacaataaa
148921 atatgtacag atgaaaatta caatatctga gatgaagcat aagcgagatgggattcgcag
148981 cagattagat atagaagaag gattaatgaa catcaaaaca tgtatgacaacagtagtata
149041 aagtctgtaa gaaaagaaat ggaaacatac tggtataagg ttttacactatgtatgaaat
149101 ggtgtagtat cacttgaaga gagactgtga ctaaagacca ctgtaacctcttagggaaag
149161 aaaaatatct ttttctaccc atcctgggtt cacagctgag gccactataacaaaaaacag
149221 attaataaca cagaagcata cacatttact taatataagt gttatgtgacacagtagcca
149281 tcataaggaa agaagactca aagaaacaga tctgagtatt tttatagtaggtttgatgaa
149341 gaatggatag tcatggagaa atataatggg gcatataata caatggggttatgatctaat
149401 ggtagtaaac tgggggaaat ttagctgggt ttgcttgttc agatttttctccttgacctt
149461 ttgtcgtgag agacaaggat gtttcttttc tctgggtata gggagggcacctctcacatg
149521 agggacttat gatctgcttc agagaagtgc cagggaagaa cagagtgaccgtcctgcttc
149581 tgcagttttc tcaaattcat acagcttaaa atatttaaca tgctaaggtgttacattttg
149641 gggtagtata tcttgatacc catcacctga aaccaaccac tttataatagtaacacaaag
149701 agttgtacat aatataccat aaaggtggta aaatggaatc attggaaaagtcaattcatc
149761 caaaagaagg ctgaaagagg aaagcaaaaa caaagaagag atgggagaaataaaaattaa
149821 atggtaggga catgagcatc cattaatttt ggtatacagg aggggcttgaggggtgtcct
149881 ggaatcaatc cccctcagat accaaaggat gactgtatat tttttaaattaagagacttt
149941 cattctttaa atattcttga cttacagttt tttaaaaaga aaaaaaatcaaagcatagta
150001 tagttgttaa atcattttaa tagtatattc agtggctgaa atgacagggagtatcaatca
150061 ttatttattc aatataaagt tatccttact gaaaaaataa gatataactgggaaatatgc
150121 ttggatccct cacacatcca cttaatttct taaaggaaga aagatgaaacacatgtaaga
150181 acagaaacaa ataaaccatt tactgtaaca ttccaggaat tgtgggatccttttcttccc
150241 aagtttattt atttgcttat ctttatctcc tagtggtagt ttgtttcctttggtagaata
150301 tatggcagtc ccacattggt gacacctggt gctcccttca tccaactggatcactttgag
150361 attcagtttt acaccttttt agcattttct ttgtgttcat atatcagttatgatgagcca
150421 ctgataatat tttgttctaa aacgaaacat attacttagt actttttttattgtctcgct
150481 gacttttaaa atttgagtga tgtacagact ttgttttttt aatgaaatataaatattttc
150541 tcatggtttc taaattcctt ataaaattaa attaattcaa tctgcaaaaatattaaatgg
150601 taagagaata aactcatcac ttagatgttc atattaaatg taaatggcctaaatacccca
150661 attaaaagtt aaaaatggtc taattgaata aaatacccat atccaactatatcttgccta
150721 taagaaaata ttgccacttg cagtataaaa atacaaatag gtaaaagataaaaggatgga
150781 aaaagacata ctattttaaa ctaataaaat attaattaat taattagtcagatttcagga
150841 cctttttctg aataattgat agaataaaca gacaaaaata tcagtaaggatacagaaaac
150901 ctccaaaata ttatcaatca ccttgaatta attaatattt atggggccaggcttggggct
150961 catgcctgta attccagcac tttggcaggc cttgagctca ggaattcgagacaagcctgg
151021 gcaacacaca cacacacaca cacacacaca cacacacaca cacgtgtatatatatatgca
151081 cacacacaca tcagctaaaa gcagcagaat acacattttc ttcaagagaacacagaatat
151141 ttagcatgat atgctatatt ctaggccata aataaatctc aacagacttaaaataattca
151201 gctaatacaa agtatattct gtaactacag tggaattaag tttgaaattaatagcaaaag
151261 atatctggca aatccccaaa tatttggtaa ctaatatcat acttctaaatgacccagggt
151321 caaataagaa atcaaaatag aaatttgaaa gtgtttgaac taaattaaacacacatttca
151381 aaacttttga gatgcaacaa cagcagtatt tagaggaaaa tttataatagtatagaccta
151441 tattagaaaa gaagatctca agccagtgat ctcagtttct acctgaagaaactagaaaaa
151501 caaaacaaat aaatccaaaa taagcagaag aaagtaagta ttaaagaccagagctgaaat
151561 caataaagta gaaaacagaa aaacaaaaca aaacaaaatt taataacacccaaaacttgt
151621 tattatacag atcagtaaga ttgataaacc actggtcaag actgattaggaatttatcaa
151681 gaagaaacga tttccttttt ttcatactgt atatgtagca cccaaaaataaataacttta
151741 gtataacatt tattcatcta atacagaaga cagaaatgag aaaagtggcatcattacaaa
151801 ttctacagat agtaaaagaa caataagata atatgataaa aaactcaggccaataaattt
151861 gacaacttag ataaattgca caaattactt atatgacaca atctaccaaagttcattcag
151921 gaagaaattg ataatcttag tagctgtata tctattaaag aaattaagttgatagttaaa
151981 aattatccta caaaacgtat tccaagctct gactgtttcc ctagagaattgtacccaata
152041 tttaaggaga aagtaattct aattctgcgt aaacttttct aggaaattgaagaggaggaa
152101 atatttccca actctccctg aggccagtgc tactctatcc aaaaccagaaaaagacattc
152161 caagaaaaca aaactacaga ccactgtatg caagaagcaa tcggaaattaaaaattgtaa
152221 aatatcattt aaaatatcag aaaaagtaat tatgaagtac ttaggaacaaacctgacaaa
152281 agtggctcaa gatttgaaca ctgaaaacta taaaacattg ctgtaagaaattaaagaggg
152341 cagaaataaa tggaaacctc atttgtgaat tagataaatt taacactgtgaagatattaa
152401 ttttccttaa attggtctat aattcaacag aatctcaatc aatacctcaataggctttta
152461 aaaatgcttg caaaatttga caagctaatc ctaaaattta tatgaaaatgcaaaggacct
152521 acaagaggca aactatcttt gaaaaagaag agtaagtttg gaagacatatacttgccctc
152581 agagctcatt ataaagctac agtaatcaag acagtgtgag actgaaataaagatagacaa
152641 agaaagacaa tttctaggtc atgagagtta tgtttcctaa aggaaggcagcagatgctta
152701 ttaactttcc ccgtgccctc aggatgcctt aaacagtggt tgccaaccactagcagcttt
152761 agcaccactt ggaagctttt tagaaaagct aattactggg cccatcccagacctactgaa
152821 ccagaatctc tgtgggcaaa gcccaggaat ctgtgttttc acaagctctccaggtgataa
152881 tgatgtccat taaagtttga gatccattgc cttggccttt ccctgctagaaatcctccag
152941 gatttgggag acaggggaag aggtctggag agagtggcag aattcaacaccacagaatga
153001 agaggaaaat tgatggtctt tgtccatgga atccattaaa atatactctcattgctgcca
153061 ggctgagctg atgaataaaa aataagctaa tctcaaatca agccatcaggctattgatga
153121 taattgtgtt ttagggtgag caaacagctt taccaagctc acacagttgagacaatttgt
153181 tgtttggaac tatcttactg taagatcctt aagaagaatg cagaagtatgaaaataaatc
153241 caggactcag aaatctttca actaaatctt taaaattctc tctctcatgcacacacacac
153301 atatgcacac atacacatat agtaagattt catgacacat gagacaggatgtgaagctga
153361 acagttcgat gaatgcctga gtggtaagat caccttgaag aaccagaagtgagggtctat
153421 tctagctggg tatgagctac aaactcattt cttggggaac acatgaacacatcggggagg
153481 ctaagtagct tctgaggcta ctaatagaat ttcagtcatt tctcctgtcatctgaaaaat
153541 atatgatatt gaatttctaa aaatgggttt agtgtagtct agtcttactgtctaaaacta
153601 agatgtggct tattccaata accaaagtga ttccatccca tgtgagggaaaaaaaggata
153661 atggtgaatt aaaagcacct gcgtgtattt gttgctcctt tagaggagtctctcttcatc
153721 aacgttaact ttctttccta cttttgatct ggctgctaaa agtctaggtttagatctcaa
153781 accattgtcc ttctctgcat gatgtaatag ttacaattac agtctcaaccctctggcatt
153841 taatgaagat gaaattgatt tctttagact gaaaacaaaa aaatcacttacaatcaggat
153901 actgaatatg gtagcaagta caaggtccca gcttctagta gacttggcagactgtcaagc
153961 tcttactaag tgaccccacc ccatgccttt ttgtcttttc tgttgccacacaattacaat
154021 aatttgttct ctgaatgcca gagtactgac aaggaaagga attctgaagctggctgagag
154081 aagtcgtgta aatctcccaa tctaggctcc attgactctt gtctctttctttgtatggaa
154141 ctgattttat aatttctgtg gcaatgaaag actagtaccc aaaatgactgctggtccttt
154201 gtttattgat caatctgagc atggactaga attcatcctc caattggtaacaagaaaaaa
154261 ttggatgggg aagcatacca ttggctaagg cagcacagca agtttgaatttggctgcctc
154321 ttctttcaat attggttgac atcatcaaga gcagacattg gcgttggagttaagagtatc
154381 aagagagtta ataaatacca atttagggta atattttatg cctagtctttatcttttggt
154441 gaagtggttt ctaatatcat ctcagactaa atcttatggg atatttctacttgtagatgc
154501 taaggtatta agaaaaagct caaagtagtt gtgttttcct tatcttcctaaaagtttaga
154561 ttaaagatgc caaaaatttg tgtgttggta tgtgtcaaag catttgaatgcccttgtaga
154621 ctattaaaac ctttgttctg taccaggcac tgtattgagt atattgcatgtatttattat
154681 tatatttagt tctcacagca accgtacaca ataattacaa ttccttcctttcactaaggc
154741 atagggagtt taaataaatt agccacagta caggatggca taaaactgtagcagagccaa
154801 aactcaaaca tgtctctgtc tgactcaaaa acataggctc attctcctagagccaggcaa
154861 caacctgaaa gctcttgagt tgacttttct agttctgtgg atgaatgcaatcatctcagg
154921 acccagataa acagaagtcc ttctttctta ttcgtatttc tcagtactaggccagtcagg
154981 acaaactctg ttctccatgg ccgtgatctt gaagaaattg agatttcatccaaaggaaat
155041 caggtattga aacgtgtgtt tatgtgtatt gattaatctt ctgcctgtttctggaaacat
155101 ttgaagaaat ataacaaaaa gcaaatatcc tgaaactgcc taatgaacctgatctctctc
155161 tctgtctttc cctttctctc tcataggtct tttgcctgta tttctctggtggaatttact
155221 aaataattat atcaggtgtc ttcttattgt acttgactgc tttcatcaaggtaatcttga
155281 ggacagagac ttcctttgtt agccagggca ctctagggga acagaaattacacacacaca
155341 cacacacaca cacacacaca cacaggaact ggttcatgga ggctaaaaagtctcaaaatc
155401 tgcaggccaa aggcttgaga acccggagtc ctcattgtgt aagttccactcagagtctga
155461 agaggggaga agacagatgt cccagctcag agacctttag gcagagagagaaaattctgt
155521 cttgctcagc ctttggttct tttcaggcct ccagtggatt agatgaggctcacccacata
155581 ggggaaggag tctgatttcc tcagtctacc aatgcaaagg ttaatctcattcagcaacat
155641 cctcacagac acacccagaa taatctttca ccaaatatct aggcactttggcccagccaa
155701 atagacacat aaaattcact tccacacttt cttactaatc cgtgcattctctccaataca
155761 gggcacccgg cctggcaagg agtaagtgct ccatatatat ttactaaatgacaagagatg
155821 agattatcct tagactatga ctcagatata gacaatcaat tattaataccctatcatttt
155881 tccccactct gacaacccaa actgaaaaat gttgggattg ccttttttgacaatatgatt
155941 ttctctgaat gcagactcat gttttgacct tccctgtctg ttcctgtttagtattcatgc
156001 tggcttaact cattgattga tcaagtaacc attgagcatc tgccgtgttaacactctgaa
156061 caagatcctg taatatgaat ggtgtttagc ctgatgaata aagtgtggtgtctgtgcatt
156121 catttttata tatttattgt ttttaaccaa actttaccca tgtaaagaataacattgatg
156181 gcaggaactt gaatttggat ctacgtacat gttccatttc agactcaccatgaaatgagg
156241 tgcttgcatt tttcattgct gattttacaa tacactttca caccttttgggtaaaatttt
156301 gcaatcaatg taactgaggc agcatggtat gaaagcaacc ctggaggtggaaatagaaga
156361 ctagaattta aatcttggtt atgccactta ttggttgtat gatttttgtcaagtcatttg
156421 acccgtgtct attcagagtt tctttgctag aatgaaggag ttaactagaatttattgatc
156481 tcagtagtca gtctcctcag gcacagataa atcttggata tgtatcctgagatagctttc
156541 ccatttccac attgaagaca acattctatt ttagagcaaa aatgaattatattatttaag
156601 aatatgagtt tcagaattca gactcatgct tacgggtttg aattctagttctgccacttt
156661 cttactatgc agactttagc aagtcagtta atgtttgtga gcctcaggtttctcaccagt
156721 aaagcagtgt gagtaataac tatcatatta tattattaca agcataaaatgaaataagag
156781 tacttggcac aaagaaggat cttaattttt agctttttaa aaaagctgtatttgtttata
156841 tgcagtatgt atatatatat tctcaattct attattatag actatatttattatgttttt
156901 cataaagtca ttagtttcac tcaggaatta gttgaccctt gtgagatacatggtttgacc
156961 acttttcact ttgatgttct tcagaaaata agacaattag aaatctctgattgtaatctt
157021 catgtaaaat attttacagt catggctaaa atgatcccag gagtggaatcatacacataa
157081 attcttttct ttattctaat aatgttacct ttagtgtcta tgccaagcaagtatgttatg
157141 tgttgagata aaaattctta gtatgtttgt atgtgacatt cccaactcccatcccactga
157201 agtctatatt tacctagttt ctttcttttg ttttcctcta acattcatgctattttaatc
157261 aatgttcttt cattttgaag cccccaataa gtttgacccc aaagactttcagtttgcccc
157321 tgctattcat aagcatactt atgacaatgc atgtctccca ttcttttctcatatttacac
157381 cgatcttttt attgggacaa atgggtttgt tttttcatgc ttgtgtttaatatctcactg
157441 agttcagcat aagttattaa acataatttt ctgttttctc tttctccctcaagactttct
157501 ttttctctag acctttattt cctaactcca gagtatttgc ccaggtctataggcccctct
157561 ctcttttgct ttcttaccaa cccatccacc ttcttctgtt tcctattgcccaactggctt
157621 cacttaaaca agagcatttg ttatttgtac agagtgcaac atataattgtcctactctgt
157681 ttggttgcta taacaaaata tcatagacta ggcagcttat aaacaacagatatttatttc
157741 tcatagttct ggaggctgga aaatccaata tccaggcact actggcagatttggtgtctg
157801 gtgagagcct acactctggt tcatagacag ccatccattt gctgtgtctccatatggtag
157861 aaagaatgaa taaagtttct ggagtcttct ttacaatggc actaatccattcatgaaggt
157921 ttcatcccat gacctaacaa taccattgta ttgggggtta tcttgcaacatatgaatttt
157981 ggggaacata agctttcaat ctatagtaat gaagtaggaa attttccctgatcctttcat
158041 gggcaggaac tggagtatgc ctatttcaca gaggtcttat cagataaaaaaattctccat
158101 taaatggcaa aacaagtaac catttgggat tcctgggtgt acagtgcctactattccaaa
158161 atgagattat tgaggctaac atgacccttt gtatacaaag acgggggcagaaataatatt
158221 tctagcaaat ccacacatct caatcacatt taatttcaca aaatttacttctaataagca
158281 ttgttccaac taacaaacca tctggtgcta gtctaagata gagatggctgaagtgctcct
158341 gattccagta ttttaggtgt taaatctcca ttctaacatt gtcaatccttaactggagta
158401 ctcaaatatt aactaacttc ctctaggata taaattaata tgtataccacattctatgtg
158461 aattatttta attatattac atgccatata caaattatat ataggtttagtcttcctgaa
158521 tattgcaagt tgagtctgtg agagaaaaaa ttaggatgaa ttgagaataactagaattca
158581 gaattctttt tcattaagtg ttgactgtgt taactcatat tcccggttaggtagcaagtc
158641 ctatgaagtg tgattttctc ctaacagcta aaaagcagaa aaaaaatggatttattctag
158701 ttaatgactt gctttttcta tttttataga aaaaatgaag taaattatttcacttttctt
158761 gatgctatta ctattttgtc aggaagatag atcttctaaa ttttaggaaactatgaatct
158821 aagttctata ttgctctcat ttcctttttc tctttgtctc tcttctgttgtagcccctcc
158881 ctcaccgcta agccttcacc ctgactctac cctgccccca ctgccttttgttctttggaa
158941 gacactcatt aacatttgct aatgtatgct aatgagcaat aattagcatctctaatgtga
159001 acaaaagcag tgctacaaag gaagggtaaa gatgtgtaca gagttcagccagccttttat
159061 gcttctttat gccttaggaa caatcctctt ctttcagttc tttcacaattctttagtgtt
159121 ttttgtttgt ttcattttgt ttgcttatcc atgaaccctg aaaaccattcttcttcttga
159181 gttagaatat tgcaaaaatg ctacggagga cagaaagatt cctttttgtcctaaataacc
159241 caaggatata agcacagctg ctaagaggtt ataatgcaca tttgtattttcatctggttg
159301 ttattttggt atcctattac tagaaaaggt tttaaccaga aaacctcacacaagataatg
159361 tatttcattt taccacactt atttacagtg gttgcccttt atggtggtaattgcaatgtg
159421 aaagcataca ctctgaatat atattatgac agcatggtta aataagaaatgttccctccc
159481 tcaaacaatc taaatgcaaa gaaaatgcaa gactcaccac ttactttttcataaccacag
159541 agggctctaa atgtctttgt aaatagctat ttatttattg aatatgtatagttttttttt
159601 tgaaaaagcc agccctccaa accacataga gtaagagctg tttttgttctttctgtagac
159661 tgatggtgtc gtgaaatacc taattgcagt ttctcacaaa tactccagcatgtaatttgc
159721 catttgcaga accaggcttc acatttcata tttgctcttc cagctcaggggtggtagaat
159781 ttggaaacat accagcaacc cacttcactc agcctgtgtt taattataatttcacgtaca
159841 ataaaagcag aaggaaaacg tgcaaaaaaa ttggtgtgca tccctttcccctccttctta
159901 cgtatataaa aaagatttat ttccattgta aaaggataga atggggatctttattttgag
159961 tagattttct atttttgttc tttctgtttg cctcagagtt agtgtcctctctctgtgacc
160021 tcagagtaaa atgtgtttct ccataggctt catcctgttc tatttatcaactatattata
160081 tttatcaatt attttatatt gtgtttttaa taaagcagac atcagcagctatttattttc
160141 tacttctgag ggcctaaaga gtctcagaaa atgagtgtaa tctagaagggaaaacattga
160201 agagtgacag ctattataac agttgtgatt tttgcctgcc tccctcttttggattggtga
160261 gtcctaccaa aaaccaaaac tattattctc cttgtaattt tgaaaccacagagattgaaa
160321 ataactattt agtatctcca agatattata atgtttgaaa atatgaccagttttgggggc
160381 atttattaca aaagtttcca gtagggtgtt tttgaatgtc tgtgccctctggttttcaca
160441 aaactggtct taaggaagat aagatactgg tacacacaga agaaatatcagcctacgtct
160501 gtctcattaa atcttatccc cagatacttt gatgatattt aagtgtaatgatctcattct
160561 gtgtttctca ctcctgataa ttttttaaat gtcttatagc ttacaggtttattaaggtat
160621 ttgatttatt taagaactac ataattattc tcttcattca atggcttctgaaatattatg
160681 tttaattcta tcatttgaag gacttgggat tgttataaac aaatggcacgagcttctttt
160741 tgtcctgacc tagaagtagc aaagataaag ggagctgctt agttaacctgagtgagattt
160801 aataatcttg ggtatatttt attctagagt aagaagaatt gcaccctattacttttattc
160861 agttttgtat gcagtagctt ctgttgtcta cttcacaacc accaatagtgttatcataaa
160921 ttcagagtgt tgggctgtat tagcccattc ttgcactgct ataaagaactacctgagaca
160981 gggtaacctg taaagaaaat aggtttaatt ggctcatggt tctgcaggctgtacagaaag
161041 catggctgct ttctgctctc cagcctcctc atggaggcct caggaaacttacaatcatgg
161101 cagaaggcaa agttgaggaa ggaggtacct cctacatggc cggagcaggaggaagagaga
161161 gaaggggaag gtgctacaca cttttaaaca agatcttgtg agaactcactattccaggaa
161221 cagcaaaggg aaagtctgcg cccatgatcc agtcacctcc caccaggcacctcttccaac
161281 actggggatt acaattagac atgagatttt ggcacaaatt tgaaccatatcctgggccat
161341 tctctatatg gagatgatgc ctgaatatga tttggtgact cagtctagcatccaagtggc
161401 tcattgttgg gcaattcttc tttagtcttc tttagggcta attttactcattccttttga
161461 aaattggatt gatttacttt ttgtttggtt ttaagaaagc aaaatatctaaatgctgttc
161521 ttggcatagc ttatatacat atacatgcat acacatgtgt aattttcttcagatcaaaat
161581 atgcatcccc atcattcgta ttgctataat cagaaattag taatttgaggggcaactgaa
161641 tgaccttata cctagagttt tcagagtata atattacaca gtgtgtattcataagaatgc
161701 tgccttttaa agaggttttt ttttaaaaaa atcatagctt attttttatagtttcactgg
161761 tctgtcctcc cttttctctc tttttttccc ccttgagaag agagatttcacatttttgtt
161821 aaggggctca taatttcctt atgaaatatg acaaatttca ctttatcttaaaagcaaaat
161881 attaatagta cagacagctg aaggtggtct gagttaacct gagttacacattttatatat
161941 atatatatat atatatatat atatatatat atatgttaaa aatatttatttgtcatatgt
162001 agcaagacta aaatgcaaaa ttttgcttta tgcttattct tttccagtatcatttactgt
162061 aattctcacc ccatatttat ttttttactt ctctttctgt ttctctcctttctcctctca
162121 ttctttttct ttcttttctt ctccctaccc catcttttag ttccatacttttgaattgct
162181 atagtggact caaatctaag caagaggtat attagtaagt tgttcagtcttttaacaaag
162241 tatcagtcag agaagcacag cccagggata aaccaaaagc agaaataaaactgaggaatt
162301 aataatctaa ttcgtgttgt tttctttaca ttataggtgg ttcatttcatagcctacatc
162361 ttcaatttct caattctcat tagatctttc ttaacagcat ataagaccattctaaatagc
162421 aaaaatagct gtatcctttt actcactgcc catcagttca taaagccacttgaattcagc
162481 tttttgccca cacaactgca ctaaacatat gcctgccaag atcatcaatatctctacatt
162541 gtcaaatcca gtggtcaatt ttcagtccac attgtactta gcaacttatgatacgtctct
162601 gatgcacatc ttctgccatc cacaatctct gactttcctt ctacttaagagctgattgtt
162661 catttttgat ttcttcagtt tgttcttctc ctgttcctca ccattttgagtctccttttt
162721 ctgttttgtt taccctcatt ttctttgtta tctcatctgg tcttatggctttaaatacaa
162781 tgtttttgct gataattccc taattcatat ttccagtcca gacctttcttctgaactcca
162841 ggctcaaata ttcaactgcc tacttaatgt catgcttgga tgtctagacagcacctgaaa
162901 tccaacggat ctgattaaag tcctgatctt taacagctcc tacctaagctattctcccta
162961 cagtcttcca tcttcttttc ctgtaattcc attcttcagg tgctcaagcaaagaacctgt
163021 tgctatcctt gatttctcta tttctctcac atcctacagg gatgacatgggttcatttat
163081 gcctgtcatg ccactgatta acatccctat caagaaagtt tagtctgaggtaaaaacatc
163141 caatttgtat gagaagggcc aacattgaca ttcttcgtac acaaaaaagaatcctgagaa
163201 gaaacacaaa agagctaaat aatacattgc tgttgcagct taggtaggctggagaagaaa
163261 cccatacata atctcaaacc ttactgttat aaagtcattc tttttttttttttttttttt
163321 ttttgagacg gagtcttgct ctttcgccca ggccagagtg cagtggcgctatctcagctc
163381 actgcaagct ccgcctcccg ggttcatacc attctcctgt ttcagcctcccgagtagctg
163441 ggactacagg cgcccaccac cacacccgga taatttttta tatttttagtagagacgggg
163501 tttcactgtg ttagccagga tggtctcgat ctcctgacct catgatccacccgccttggc
163561 catttttttt tttttttttt taagagggag tcttattctg tggcccaggctggagagcag
163621 tggcacaatc tcggctcact gcaacctctg cctcccgggt tcaggtgattctcctgactc
163681 agcctcctga gtagctggga ttacaggcgc ctgccaccaa gcccagctaatttttgtgtt
163741 tgtagtagag gcggggtttc accttgctgt ccaggctggt cttaaactcctgacctcaag
163801 tgattcatcc acctcagcct cccaaagtgc tgggattaca ggcgtgagccactgcgcctg
163861 gcctataaag tcattctttt gcatcaaata gtaagactca ttaaaggcagtggtattttc
163921 ttttactgtc tacaaaccct tatccaagag cattttctct atattcctttgtgagcacac
163981 aataaatggt aattcaataa gtgaattttc agtttccaaa ataataacctggagctataa
164041 acattgcttc aagaagtaaa tgtgggtcag agaaaaaggc aataccattcaactcttctg
164101 gccacttggt cactgtgtta tcctgaagaa gcataaacta ctttcagcattatagattta
164161 aaaagaagcc ccagaacaac atccactttt ctgaacgact cctatgcctctgaaatgtga
164221 cattttgctg ttgtttcttt ttactgtttt taattactga gtctatctgcatgaaatgag
164281 gatctgggtt gcctaggagt tcatctgctc ctattgcata ttcctcttttaactacacat
164341 acttcaatgc agttttgctt gctgcctcca acattttgac agacttcccctcctcttcct
164401 tcactatcct cccatcactc tccaggagac aaggttattt ttaaagtgcatgatcaatgg
164461 gcattgggga gcagctgagg catgaagaga tcatacgatt gggaataaggtactagggac
164521 tgctgagaga aggaatggca acatgccatc tcagacattg tctgagaaaggaaagggttt
164581 gtagctccca ttcaagtatt ctgagctatc tcttcacaca ggtttttgtcttggagggag
164641 ttcttaacat agttctttag cattgcttta agttgaagga gatataggccagtgctgata
164701 gttacttttc aggccaaata atgttccatt aaaatcgagc ttgctctgaggatcttggta
164761 gtgtcttaaa tctcctggtc atagtgctgc tatttggttc ttgatgcttatgacaccttt
164821 gctgagggtt tgaatcaaga acaaaacaag tattatcaca atgactataaaacatgactg
164881 ttccacgatc agacaaagga atgctgttaa gcaaagaagg cacctaaggagaatgtggag
164941 atgaccatgc acagaccaga atcactattg gaaaaccaac tcaagaggagggactgggtc
165001 atttctgcag cagtcttcat tgcatcactg agaaattgca gctctgttttagttctctac
165061 ttgccaccac agggaatatc ttcccttatg gacttttagg ttttatttaatggttattta
165121 taaactattc cttctgtgcc ggagaagatg attcatgact ctagccctgctttttctctc
165181 ccgtggttat tagaggaaac tgagttgttg cttatctctt tagcttgggataccttattc
165241 tgctcttttt atttaatata taatctttcc taaagatttc cttatatttttgttcattta
165301 gtaggttttt ctgttttatt taattaactt tatattatca cattctagtgaaataatcat
165361 cacaaatcat cctaatacat cgtgcaaatg ttttaaaaat gtgctttggttgtgcatatc
165421 gcaaagtagg ctgtgggtca gcatttgcta tttgtcctca gctgtttcttctttatatat
165481 aactgataac accctgctcc aatgttaatc ttatatcatt aaaattctttcctagagaat
165541 ccttctttga ctgaagaagc ttagtggtga cattaattgc aaataaaagaccatgaccta
165601 ttgtagaatg tggaatatct ccttagaagt gtctgccttc attattgcaaactttcagta
165661 gtgacataaa gatctttgtc ctgtgtagtt tcagttgcag ccagcaacagaaggcatatg
165721 ttcactttga acaaaagaac atttattttc acattctgtg gctgatgttgagtgataaca
165781 tttttgcata tcctaaaatt ttttacccag atgctgttta aaggcaaaaagtgcttttac
165841 aataatattc tttgtgaatg gaatttacac tcttggcatg tgttgccttttcaatatgcc
165901 catcaagttc tgaataataa cctttgacag tgagtgaaca gaaacaaaaccagaggttgt
165961 ttcatctgtt cacagcaaca ctgtttgtca tctttgcttt tttggaaaaatgtcattcca
166021 ccttaaataa aaatatgata aaattcatgt tttataagca agttaatagacttcgattat
166081 taagaaatat tttaattttt ccaaggcaag aaacctgtga tgaatgaacattaagttgac
166141 aaaagaaaaa aatatgccaa taaatatatt ttttcatatt actgtagtgtcaaaaatttt
166201 ataaaacttt tatatgcctt tataaaaatg aagcaaagct aagaagaagatgctgtatgt
166261 gttatggggt gaggaataaa cagaaaaagt gtcctttgtc ttggaaagaactgtaaaatc
166321 acctatctcc atgttgccaa agggaatcac atattgggaa atttaggctatattaatata
166381 atacgtataa aaataattga aatagaaaag atctggcttt aagcatttttctaaagactt
166441 tttcatgctt ggtaaaagtg tttggaataa attattctct atttttaagtagttaatttg
166501 gttattaacc taattggtat gggcatgtgg atatagcttt attaacaattcaatttctca
166561 tgaaataaaa taacccgaca aaccccaagt ctacttattg caatacagaatttattttgg
166621 ttgaagttat tttgaattga gctgatagct tataactttg aattgggcttataactgtta
166681 tgttttgcaa atccctgaag attatgaaat agaaaaatct ttgcatggcattgtataaga
166741 tgctgtagct gtatatcttt aataaatcgt gctcattttg gcaagtttatggaaaaattg
166801 tattaactgc acaaaaacat tatgataaaa acaataaaag taaaaaccacttactaacaa
166861 ttgtacaggc atttaaataa ttgctgtact gttttctttc ctcaacagtacaaatcaaag
166921 tggaggaaaa agaagacgag actgaggaaa gctcaagtaa gtggtgatgggccacttggg
166981 atacatttcc tatggaatac cagtaaactc aaagaattta tcctcttgtggacttgagct
167041 accatatgta agcagaagtg tgtgtggata acttttcatg gtctcacaggaggaatcaag
167101 ttcagcaaac agaatcccca ctctagagtc tatccagttg gcactataagggccaagact
167161 gtgttccctt gattgcttgc tgaaaaatca acaagcaaaa gacatgttaataggagaaaa
167221 ggcatataat ttcatagaac ttgtattcat taaagcctta ggatgaagacccaaagatag
167281 agaaaattgt ccatttttat gcttaggttc aacaaagtgt ggatagcagtgtagaaatat
167341 gattggacga aaagggtata atctaatgtt tacatagagt ggggaaacacaacaaggcct
167401 gtctgcctag attcttcttg gcctctctaa gcatgcattt ctttcttctgggtatggggc
167461 agggaccctc tttggaatga gggtcttatg atctacactc aaacaaggtaggtcggatga
167521 tttcttgatg accagttttt acacagacag ggcagaggga atgttagagtagtattttta
167581 ggtttcatgc atttgagaag aatgtttatt ctgttgttat tgggtagaatgttctgtata
167641 tgtctgctag gtctgtttga tctataatgt tgttcatgac tgctgtttccttattgattt
167701 tctgtctaga tgttctatcc attatggaat gtaatgtagg gtattgaagtttcctactat
167761 aattatattg ctgtatattt tctctcttga gtttggttaa tgtttatatttaggtgctct
167821 gatgttggat gcatatatac ttataattgt gatatcttcc tggtaaattgacccttttat
167881 tactatttaa tgcccttatt tgttgcttat gacagtttta tactaaaagcatattttgtc
167941 cgatgtaagt atagccaccc ctgttctttt ttagctacca tttgcatggcctatcatttt
168001 ccgttccttc actttcaccc tatgtgtgtc cttaaatcta aagtgaatcttttatagtta
168061 gcatacagtt gtttcttttc tttggtttct tttttaattc attcagccactttatgtctt
168121 ttgattgaga agttcaatcc acttaaattt aaagttatta ttgatagagcaagactaact
168181 tttgccattt tgttcattgt tttctgtctt aaagctcttt tgtcccttttttatctcatg
168241 ttattctcct tcatatttta ttgattttta ttatagtgat atactttgattcctttctct
168301 tttcttttgt gtgtcttcta tagaaatttt attgtggtta ccatgggactcatgttcaac
168361 atcttataat tataaaagtc ctattttaag tagaaaacaa tttaacctcaattgcatact
168421 aaaactctac acttctactt tccttgacac ttaatattat tgacatcttgagttacatat
168481 ttttatatta tgcatccatt aacgtatttt tatagttact gttaatacttttttactttt
168541 ataatacaat taaaagttac caatatactg tcattaaagt attatagtatcctgtatttg
168601 tctacatatt tacctttacc agacagtttt atattttcat gtgattttgtgttgctcttt
168661 agtgtcctct cttttcaact tgaagaactt cctttagcat tacttgtaagaaaagtctag
168721 gggtgattaa cttaggtttt gtttgtctga gagtctttat ttctctgtcatttataaagg
168781 acaaacttgc tgagcatagc tttcttggtt ggcaggtttc ttctttccaacacttttaaa
168841 atatcatcct actttcttct ggcctgcata atttctgcta agaaatgatagtcttatgaa
168901 ggtttccttg tacatgacaa gttgcttttc tgtttctttc aaaattctgtctttgtcttt
168961 gacttctggc aatttaagta taatatgtat tggtgtggat ttatttgggttcacataatt
169021 tagggtctgt gggcttcctg aatctgaggg tccattttct ttcccagatttgggaagatt
169081 ttggttatta ttttctttga atagtctttc tggccttttc tttcttttattctccttcag
169141 aactcccata gtgtatatat tggtctgctt gttgatccct cataaaactttcttgacttt
169201 ttcttattct ttttatggtt ttgctcttct aactataatt tcaaacatcctatttttcaa
169261 tttggtaatt ctttcttttg cttgatcgag tctgctgtta gacctctgtagtgaatttct
169321 gttactctat tcttcagtta ttgtgttcag ttattgtctt gtactcttcaatatttatct
169381 ctggttattt ttatattttt atttctgttg aaactcatac tttgttcatgcatttttctt
169441 ctgaatttgt tgagcatctt tatgagttat ttttaatagt ctgttaagtaattcatatat
169501 ctccattata ttagggctgg tttctggagc tttatcttct gttgtttggggtatgttttc
169561 ctgtttcttt atttttcttg attttgtttg tttgttttgg tatccatatattagaaaaaa
169621 cagattcctt tcccagcctt caggagaagg attagccttg tacaggagaagagtttcacc
169681 aatgaggcag gccagagatt cttgggcctc tcaaacattt cctgtgtatgcatcgtctct
169741 ggacttgtgt gtgtaaattc tcaataagag ggatttttca gttgactttttctttttaag
169801 aattcataat ctcttgttcc ctccagtgtc cttctgtcat aacatgtgtcttctgaggaa
169861 gcagcatgtc ctgagttctt ttttttgttt ccagtagtcc ccaggcatcaacagtatgct
169921 gggtcctgtc catgccctga gactggtcat tcccttaggc agcctcctgagaagtctgaa
169981 cacagggtat atatttcagt cttttatttc ccatttcagg ggcaagtcaagggctggaat
170041 tcttgccaac tgtgtcatgc tgaactgggg gaaggggctc tggtgaatgagtacaaacta
170101 attcaaaact tcacctttgt tctccatggc cctgggccat ttagaatatgctgggtccta
170161 ttagtgctct aggagacaag tgggacagaa gccagtccag tcattttttagaaaagttgg
170221 agtgttagat gcactatcca actgtttttc tccccagaga ggtgcagatttggtgtttat
170281 catctggtta ttctgtgcta aattggggga gtggctattt gagtgaggcatactattcaa
170341 acggctatct ttgctctcat tggttcctaa ccagaggtct tttcctgtcagtgctcagat
170401 tctggcaaga cagaaaccag tcctttggga acctccagaa aaatcagaatgttgaacaca
170461 tggttcagtt gttttctccc ctccccaggg agagactggg agatgatggttttctcccag
170521 ttgtatggta ttgtgttagc agagagggat tatggtgtga gggtgtgtcagatttttcta
170581 ccagctacct agctgatttt gtgttcatct agggttcagg cacctttcaactagtttccg
170641 aatttctcac gaagggagct tatctccaca ttgtagttga acttttatgtccatggaggg
170701 aaggcgggtc cagggcttcc tattttgtca tcttgttgat gtcatcccagtagtttagtt
170761 ttaatacaaa aaatactaaa attcagagta ccaagtagct gcttgggtttgtgagttatt
170821 agtgggtaaa ttgtttcttg cctcctgtca agtttttgtc ctttctttaattagtgacta
170881 atgtggctaa taaaagcagg gtaaatattc agaatgccat gatggggttcaaataacata
170941 catttgccac aatattaaac aaacagaaac tcgttcttga tttggatgacagaatatata
171001 tacagttttc caagcccagt tagaaaagtt attatgggcc gggtgcgatacctcacacct
171061 gtaatcccag cactttggga ggccaaggca ggtgaatcac ttgaggccaggagttcacga
171121 ccagcctggc caacatggtg aaaccccatc tctactaaaa atacaaaaaattagctgggt
171181 atgatggcgc acacctgtat tctcaactac tcaggaggct gagacaagagaatcgtttga
171241 actctggagc tggaggttgc agtgagccga gactgtgcta ttgtactccagcttgggtga
171301 tagaacaaaa ttgtgtctca aaaaaaaaaa aaaagtgaag ttattctgttttttactctc
171361 tgctacctga catttagtaa tatatgtaat atttagatct tatacctgaaatatcaataa
171421 aaaagtttta acaagtggta attaaagata attttgaaaa aataaaatgatgactcacac
171481 gtatgtgaaa agaacatatt taactaataa aacaacttgt gagatgctataatcagttca
171541 aaggaacgtc caaagaatag atacatttat agataataaa tattgaaatgattgtacaaa
171601 tgaaggcaaa gttgtttttg aaagggggct tgtctctcct ttggaaagagttcatttgga
171661 tgtctacaga taaaaagtgt tttgtattgc tatatatggt tatgtataattttcaaagtt
171721 gtcatatagt tctcataaaa tcagaatcag ataacacaga aaggtatgctgcagataatt
171781 catagttttc cattgaaata taattttttc tctggggtag cctctatttaagagagtaat
171841 gataactgta atatttaatt ttttacagta gtttatgcta aatgttagaagttaggagca
171901 atagaaatga aactggaata gtaatgttat gttataaact ttgtgaaggaaattttatct
171961 taattatctt aatttatctt aattatctct ctattcttta cctggaagcatcctaaaaag
172021 ttatgaacac atgaggcatt cattgttgtt gatgatgaaa caaaataatgctgtcattat
172081 tctcaatttt acattaaatt tatgttacct atttctattc ataagaaataaatgatcaag
172141 caaatgtgta tactactttt ttttttaaag aaaagaacaa aaatattgaggaaaaaggag
172201 aaaaatattt agaatcaaga atgaagaaaa tttaaattga gaggaacctcaagggttgaa
172261 tgaatttctc caaaattatt ctagtttgta gcacctcttt aacgttcctcttctttgttc
172321 taagatagaa gtagtaataa atatgaagtg gttaatcact caacaattatgtaatggaat
172381 ggtaatctct aaacttggac ttatttgaat ggtcttagag gtcatggtatgatattaacc
172441 accaagctat ttagttactc aagtaaatga agaccagaac ttcttcaaaaacttattaaa
172501 atttgggaat ccacattcac ctatttgagt cggtgaacca caatggaaatggaaatctag
172561 atacatttat ttaaatgatg ggctatgaaa tatgtattcc atgatgcatcccatcacgat
172621 gtggagaatt gctagactgt gctgtcagat gtgtaataat agttattaaaaactaagaat
172681 aagcttggta gtgggaggaa gcactttctg acattactca ttgaatcaagtgctatgttt
172741 aggtgaagag gaagaggagg tggaagataa gctacctcga agagagagcttgagaccaaa
172801 gaggaaacgg accagagatg ttatcaatga ggatgaccca gaacctgaaccagaggatga
172861 agaaacaagg aaggcaagag aaaaagagag gaggaggagg ctaaagagaggagcgtaagt
172921 tagttctgat attctttcaa aagttccaat gctgaagaag atcactcctttcagatactc
172981 tttgacctta aaattggtaa ttaaagctac ttttagaaag agagccttaatctgatgatg
173041 ctattttatt ctacttaatt aaatgtattt taatggttaa aatagaattttaaaatgaat
173101 atatattaaa aatggaccat gagaaattct cttatgaagg atctgaattatcataggtcg
173161 ttgacatatt acagttaatt taaagatttt aaaatttccc cactaattgtatgcattgtt
173221 atctaggtta agtagaaact cctaaatagt gagcaaacat cactttatcttacagagcag
173281 gggttggaaa attatggcta aatccagccc aagaggtaag aatggtttttacagcttcaa
173341 agggtcatta ataaaaagca acaaatatgg gacagagttg tacatctcactcaaagctta
173401 aaatattaac tatttggccc tttatagaaa gaaagtgtgc tagcccttgttacagaggat
173461 ttgggttgtc attttctttt taatacaact caatatcttt tagttccaccaggaaaacat
173521 tttagtaaac gctgactttg tgtagaataa tgcattaaat gctgtttaggaaaaatccaa
173581 gaaaatactt ttcttctttt tgctttttgg aaatttgcag atagcaggcaggtaggaaaa
173641 atgtacgtgt aaaacacctc taattaaaga gaaaacctag accccttggaaagaatgcaa
173701 gagaacagcc aacctgttcc acaactcaca ggtaataggg ccatgcgagtcgccatcagg
173761 tggtggaatc tcctccaaac actcctagga ctttgaagca tgaggaactttctaagatgt
173821 cctcccaaga tgacacactt ctatactcaa tagctctaac tattgtgttattccttataa
173881 atgattgtca ttaaaaacaa ctgaatgaaa aatttgtcaa gtagagaagcttagcattaa
173941 caaaaaatgg tttcttttag aataagaata acaccatcta cttcatgtctaagttttcct
174001 cctcctcttc cccagctttt cctttctccc ttttgaatac caagacaaaacttgctttta
174061 aattttgact ctagtatttt ttatttatat ctgcttttaa agtttctttatgctttattc
174121 ctttcaaaaa taaaatgcaa cacattttat gtcccatgta ttactatgattgttagttcc
174181 attattatgt agtaatagtt cctatttagc aaagcttatg ctttccaacagtggtatttc
174241 attgagaaaa catctccaat tgatgtatgc atgatatagg ttgtgttccaaaatttgctt
174301 ttcctctcta tttatgccgc aaaaaaatcc ttttaaaaag atgagttggacaggaattcc
174361 tctgctctct tcgtctgctg atggccctca tggcaactgc tcaacttctaggaaatgggg
174421 ccatgtgaag caactggatc ctgtggctat gacagtgtct cttcctagctggcctcactt
174481 tcattttgat cttgagaatc aagatccctt acctcccact cttccacataacccaactct
174541 ctccataggt tttgcaaatt gtatttttgc tgcgacaatt tgtgcatctattataaatag
174601 tatcagaaat tagttgtgat tattgatagt tctgttctct attttagagtctattttcta
174661 ttgttcattt tgaagataaa catctttttt ttaaaagaaa atcttagataatatttttga
174721 gaaagattag tagccaaatc agggcacatt tatgtaggtt aattaattcagggtattttt
174781 tatttaacta ttcaagtaat gcctcaggga atttcccttg cattgacacaacatttgaaa
174841 ccaactaaaa ccaaggttgt aatgctaact atctttggag gcagttaaaaaaacactgcc
174901 ttgttagaca ttttggagta tttccagtaa tattacaggc ttttcctgacccagttttaa
174961 gtggataagt aatatattca tagcagtgag aaattcagca tattatgccttcttcttcct
175021 aacaactgtt gtttaaatat atcaaactta agatagaaaa ccattcttgcacagattagc
175081 ctgaaaattt agatgaggca tgcctatgcc ttttaatatg attagccctttctttgagtg
175141 attctagaaa agcaggtttc ctgtaatgct gattagaaaa gtattttaattaccttcata
175201 tttgagggta acttatgtgt caacaactgt accctgtaac acagcctgatcctcctggtg
175261 aaataaacaa ttaacaacag agacttaaaa gatataccaa tctggggtcatttagtacag
175321 gaataaacgt ctttccatac cataataatc tcagaggtag ttgttatattttagtgtact
175381 ttgagcactg ggtttatgat gataaccctg agcaatccag aaaagttttgtatacatatg
175441 ttcattcaat aagttattta cccagctcta cttttgtgca acctaatttgcttatatctt
175501 tgggatactt ggatatgaac atgtaattgc ccacaatctt gcaatcttcaaaagtccata
175561 atatagtaag ggataggcca cttagataca aattattatg acataagaaagtatatgtgt
175621 cccagagaaa tacaaacaaa gtagcttgga gtctcagagaagtgaaaactgttctcacag
175681 ggatagttag aaaagggatt cttaaagaca tttcatatga tttttaaaggacttgaaatt
175741 tggacaagct gaacttataa actatttaat tagtattaga attgtttctattaaagggtc
175801 tctgaaagtt ggcctgtagg tttagttacc tggcaaatcc acacatcaaatagataattc
175861 tttcattctt tggtgatgtt ggattagaga tgctgtttta catgtgattcttaatggaag
175921 ttcagtagtg taaagcttta aggtaattat atgtaaatat catgaattattttgaaatgg
175981 ttggcaagtt aaaggcttaa catatcaagc aattaaatta ttaatcataaagattttttc
176041 taattgactt tattactgat aatttcttgc catctgtttt attttatttttgctagtttc
176101 tgaaaatatt tcaataaaac tgctatctat gtaatttaaa gttattcctatgtttgcatg
176161 gaaacaattg tgatcatttt aattaaaaca catctttacc tcctaagacaaactaaccca
176221 catatcattc taattggcaa attaaaaaaa aaaattgtgg atatagatagagtaaaaaaa
176281 atcctgaaat attttatgcc atggctacac agcatcatag gcttttatatgataaacacc
176341 aaataatgaa aatagaaaca acccaatggc tatcagagat gtatcttagaagagtgtact
176401 tccctggttc tcttgaacca aaatgattat tctaagcaaa atgtttgaattgtccaaaaa
176461 acaaactgtc aataggaagt gttattttaa agggttaata tgaatttttgtttcagtaat
176521 catagcatga ttaaaaacta taaattggtg gcaaataaag gagattgaaagtcattttgt
176581 aaggtgaact ataaaactgt ggatatgtcc ttttcctcaa ctagaactttaaaaagcagc
176641 ttttgcctta tttctactgt atctagtcat aaattatttt tctgagtaatactgaattgg
176701 attacaattt ttgttattgg tcaatatcta gtgaggggag aaacttcaacagttaattga
176761 acagagagaa tttaataagt gaattgttag gaggtataaa tgttaattagactgcagaaa
176821 aggtaaaaag agaacactaa agtatcatag tgacggtaac tactggaagcagctaccatc
176881 ccaagggctg gaggaacaat ggaaagggtt gaaacgaaaa cactgtagcgtagaggaaag
176941 accctaggag ctaaaactca ggcctctgca gaggggctga tgctctgtggtgctggtttc
177001 tgtgggagag gtgatgaagc tggttctgct agtgttggta atattggtgataaggattca
177061 cttgcagtat ggcaaggacg ctcagctcca ggagtgaaga agagatgctaaggaggaagt
177121 gtcaccccac aaagcaaata tgaagcagag aggaagccac aggaaagacggagaccctct
177181 tcagtatccc ctattgtcag agtatatatt gacccagcta acaaagcagaaatatgactc
177241 acaaaatacc agccccagca ccacaatatt aaagtgtagg agggtgtgtttgaagttggg
177301 acaatagctt aaaaactgaa ataatctatt accaaaaagc tgatctctacaatgtggtat
177361 tgcatgcctc gatttaaaat tatgttgctc ttgtttagat tttgtttcctttgagttctg
177421 gaccgcatag tgttttcgta atactaggaa cacagaaaag aaaagctacatctcatgctc
177481 agtaggaact aaattccttt gaagatctct tcaaaggatt cacttccaccaaatatattt
177541 caaggtgaat tttaccaaat gaagttataa gtttaattaa cagataacattaagttacct
177601 ttgagaaata gatttttatt tttcccgatt tcaatttttc tttctttctttctcttgaga
177661 cagggctaac aaaattttta agggcaaaga catcttcacc cctaatttattatccttatt
177721 gagaaataaa atatttaaac gaaatgtaga attgagggaa ggtattcaagggaacaaaga
177781 agagagggaa atatcttgat atatctgtaa ttattctttc cacagattttctggttcaga
177841 gagtttgagg ctctagacat aaaagaattg cttagggcgg gtgcggtggctcacacctgt
177901 aatcccagca cattgggagg ccggggaggg tggatcacct gaggtcagaagttcaagacc
177961 agcctggcca acgtggtgaa actctgtctc taataaaaat acaaaaattagccgggcaag
178021 atggcagatg cctgtaatcc cagctactgg ggagcctgag gcaggagaattgcttgaacc
178081 tgagaggtgg aggttgcagt gagccgagat tgtcccactg cactccagcctgggcaacag
178141 aacgagactc tgtctcaaaa aaaaaaaaaa aaaaaaaaaa gcccggcttatgcctgtaat
178201 cccagcactt tgggaggccg aggtgggcag atcacctgag gtcaggagttcgagaccagc
178261 ctggccaaga tggtgaaacc cccatctcta ttaaaaatat aaaaattagctgggctaggt
178321 ggtgggcgcc tgtaatccca gctactcggg aggctgaggt agattgcttgaacctgggag
178381 gcagaggttg cagtgagcca agatcgcacc attgcactac agcctgggtgacaagagcaa
178441 aactccatct caaaaaaaaa aaaagaaaag aaaagaaaaa aacagaatggcttagattca
178501 gattcaggaa ggcaaacact actgcttaaa gttataatag ttccagtaatcctgcatcag
178561 tgttcagatt tgagttctca tgcttatggg tcctaatgtt gactgcatatggttacattt
178621 aaaaaaaatg agctaaatat ctgatacctg ccttccttaa gttccaaagtcaagcaaagc
178681 ttaactttat taaggtgttt cttttttact tttaaagaga agaagaagaaattgatgaag
178741 aggaattgga aagattgaag gcagagttag atgagaaaag acaaataattgctactgtca
178801 aatgcaaacc atggaagatg gagaagaaaa ttgaagttct caagtatggtgccacttttt
178861 ataagtagaa acactttccc tgatattgat tttctaaatc ctctgaatattccatatata
178921 tatatatata tatatatata tatacacaca cacacacaca tacacacacacacacacaca
178981 tacactgtat atatagtata tgtaatacta tatatatcat ttatatatgactcattatat
179041 ataatggtca cagtcataaa catgtatatc atatttctgc atatatacccaaatatatgt
179101 atatttacat atatctgttt cttatcacta gagagactgg gctaatgattataaattgga
179161 agcaactctg agaaattatt tagagtcttt taaattcttt ggtcatctttaatcatttgt
179221 tccttaaact ggagtttcct tagcttaata catttgttac catctctttgaaagagataa
179281 tatatttgaa ttttacaagt ttgtgtggat tgtgcactct tgtttctcttcagggccctg
179341 gtctcaaatg aacttttcat gtgacagctt acattaaagc acagagaagatgctaggcca
179401 acagaatagt aaataggatt ccaattaaag gttatgctaa tagctattccccgaacatgt
179461 cagtgaccca atttcagtct tatgttgatg ctaatgtgga cgcgaacgcagtcagagcac
179521 acagatttat aaactcttca tatgaaaagt caaatgatta tcctattctgggggatggga
179581 agattcaccc ctgaggatca cactatattt ccctgccctg gtggttgggagaggaggaaa
179641 gggcagggaa aagggaaact gtttgtgata acagccatgt ttgcatctcctagttttgcc
179701 aaagattgca ttcttccata aatcattttt ataaatagta gtaagttttaaaaactatcc
179761 cttcacaagc ctatttaact agtaatgctg taaaaatgat agtatagtattattgtctct
179821 gatgatgaaa acaagaactg aaatagctat caggataatt cacttctagtcttggttctg
179881 caagagcttg tgtgctattt aaaggtatcg cttaatctcc tgaagccttagttacctcat
179941 atccaaaata aagaaagata ttctatatct tctctgtgcg cttgaagcgtagccatcatt
180001 tatagtattt ttgttttgtt ttgtagagta aggttttcca agttctaaacaatggttttc
180061 ccagaaaact tttgcaacac cacaaaattg cagtctggga actccctttgcatgctcatg
180121 tacacatcca tcataaatga aggcaaaggc aagcagcatc ctacgttccacagagctaca
180181 aattttgtgt atgcatgctc atgtgtctgt acattaaaat aattttcatttagcgaagtg
180241 ataatgatgc taaattatag gttttaaaaa tattcttacc tggcaaaatagaagtttggc
180301 aaccctatgt gggcctctca aatatatttg aaatattaat gacccataaagtccccaaac
180361 ttgggaactt cagataacta tatatagaaa gtttaaaatt ggagcaatattgtgaacttc
180421 caaaatatat gattgaataa aaattccaag gactaccttt cctttccaactgcatggagg
180481 tgtagaaata cccccctggt ctttgcccgt atctctcgtg caggatcgtggaggagacag
180541 cagcttcaga tttgagttag gatctcagat cttccattta atagctgtgcacatttgatc
180601 gagttgtgta gtctctctac acaactcagg ttccttatga aattgtaccttattgacaga
180661 gtttttggaa ttataaaatg agataattta tgtaaaacat gttgccagaacttggcacat
180721 agctgggaaa cctaagttgt agttattact tcatctcaga acagacttgatgcccaattc
180781 ctgaagggtg acaagagaga tggagagaat ttgggacctg gcaagtctaggtgggagcag
180841 acctagtcac aatcagaccc cagaagcctt gtgggatggt gacacattggtaccagtttg
180901 gataaacaat aagattttga ggatgcaaca gaaggaagta aggcatttgacaatttagca
180961 aaatccagga ccagaccgtt ctcagatctt ctaaaacata gccatagttctgtggcagat
181021 ttcaaggtct caggccttgg tctggagtcc aagagttaag caaattttagcaatggggag
181081 agataggcat tagcattgga aagaaggaca atacgagccc ttagtacgaaagcagacact
181141 gacaataagg agaccgcacc tgactctaat ctagacatag gtttttttatttggcccaca
181201 tgtgttttgt ttctttttct tttatttttt ttaaccgtgg caatatatacaatacaaaat
181261 tcaccatttt aaccatgaaa tcgattttct ttatcataat ttttttcaatatttttaaaa
181321 atttaaatta cttttttttt ctcgagacag ggtcttaact ctgttgcccatgctggagtg
181381 cagtggtgct atcttagctc actgcagcct caatctcctg ggagcaagggatccttctgc
181441 ctcagtctac cacgtacctg ggactatatg tgcacactac catgtttggctaattttttc
181501 tttttgtgta gggatggggt cttactatgt cgcccaggct gatctcgaactcctggcctc
181561 aagccatctt cctacctcag cctcccaaag tgctgagatt ataggcatgagccactgcac
181621 ccagcctcaa tcttttaaaa gtgggagtaa aatattcaga tgttcagcttttcatgaaca
181681 agtggaagat ttggtcctac attcttccat cacagtaaca gctaggactaagcacctggc
181741 ctctattaat ggggcattcc tttttcaatt tgcaccattc tcaaacaatccatattactt
181801 gtttatgctg cttggctgga ccctgtagac attcagattt gctgcctcctaccagtgcag
181861 ctggggaaca agctaggcat gttaccaaga cggtgattca gatcttcaaagccaaagtca
181921 gctcacagaa tggaagcaca aatttagtcc cagaaaagaa acaactgtggcttctcacat
181981 gtcagcaagg ctcacagtct ggtgatgatt ttccatggcc agaagtggtttctgccttgt
182041 ggccgcacct atgggttcca gctggtgcca tggccggggc cagcctaattcttttggttt
182101 cagtctccgt gatgaagttg ttggtactta agtgcctgac ttatctctctttgaatgctc
182161 tattgagctt tttttgaatg ttctattgag cttctcccca ccagattccaactacattat
182221 tagaacaagt ggtcagtact tcacagaacg tgcaggtaaa tgtttctctaccccaatgcc
182281 accaatgctt gggagtgagg cagctttccc tctacccttt atttctttcagagacatcta
182341 actttgagag cgtgtttcta aggattatgt tattaatatt ccccaaattagcctgcatca
182401 tcgctcctgg ctaagtctgt gaaacccaag atactaagct cagtgtaactgaaagagatg
182461 ttttgatcac agctttgaat ctgtgcctgg gttcgaagcc ttcttgttctggacttggag
182521 aaagttttga aacttctaaa agatatttta gacagtgtca gggttttaagatatatttta
182581 gagtaagcct caggaatggc aacttatggt tctgagggtg ttatgggagactcagagata
182641 gttcccacat ttttaaagag catctaccat taggaacccg agcacactcagggcttagga
182701 tcaaaagatg gttaatataa gtggttgcta cataggcagg cagctctaggaattggttgt
182761 gaatccatat taatcctcaa acatggctca ggagctagag ttcagcattttcaagatagc
182821 agaattggct ctatacagct gaaaggaagc catctccttt tcatcatcactgtggaaatt
182881 gtgattttca ttctatgttt tattgtatat caatacaatt tcacacattcctgtagcctt
182941 aaacctactg aatgataatc tcttggtgga aaggcaggtg tgtctggcccagaccagaaa
183001 tgtatatttt tattttttga tctaaaaatt actgatatat agtcagaatgaaagctgctg
183061 ttttcaattc tgagagacag aaagctccac taaacagaat actcagctctacagatgatt
183121 tatacaatga ggaagagtgt gtgtagggag ttggaggggg gtaagggaaacagtgtcata
183181 ttttccaatt atttgaaagt caatttctat attttattaa tcacatcatttaaaaatatc
183241 cattaatgag aatactaagt ataatctgtt tttaagctgt tcatgggtttaattcagagg
183301 ctgtatgact agatctttcc tacctataag aggtcgcagc acttacctgatagcagccac
183361 cacaagtgaa ataaaatacc caggtagaaa gtaacaggtc tacttattacttgtcttgaa
183421 acctaagact tttaactgta tcagaacatt atatgtggta gattgaaagtgctcatgact
183481 aaacctaaat aagcaaccac cttattttgt tacagtagaa taggttttagactgaaaatt
183541 gagacttgga ctttgagcta agtgcttcct ataacttctc tttgaacctccatttattca
183601 tttataaaac agataaattg gattgtggac catggtcttc aaactgctatcctccaaagt
183661 caagcagttt ggtgaaatca aatcagggca aaggaggcag aggtcgcagggagagctact
183721 gggccacaat gccggcttca aaaacagacc tatggtttct ctcttctacacagtgtactt
183781 ccatataaag cattgattgg aagaaagaat gcttctgtgg ctattaaaataaaaaacagt
183841 tttaaaaacc cacttagctg gatatttaaa gaaacttatt ttggagaagggacagttcta
183901 acatttcatg agtctacaaa ttaggataca gaaacactcc aagtatacttttgcagggaa
183961 ttggcttttg gatagacacc attttaaaat gatttatttt gataacaaaaatgtttattt
184021 agctattata ctgactactt taatttctga gctttgtagt accctgacctattgtttctg
184081 ggagttgtcc attggctggc taggcctggt gatttattaa tgagacacccagtaaagcca
184141 ggaaagttat cctcagattt cattcacact taaacaggtg cttcaaactgtcagctggcc
184201 attaaggtaa cattcctcct tactcaatct cccttgatct tttcacacttcttttcattt
184261 gtttgtttgt tttttatttt gttttatttt ttagttggga gaatgaatacatttttagga
184321 aagtgaaaac agaccatggt tgatttcctc taatggagct gttgggaaaactttgggaaa
184381 actatttatt tggcttccat tctcaccctt tctctcctgt tttcttgtagcttaagattt
184441 tcacaggcaa gaatcatggt ttatacttta gtttttctct catctgtcattgtgaaggaa
184501 taaaagatgc tatacaagag gacatttaag cgtgtgaaca cacccaccaacataccctca
184561 aaccattctg gattattttc ttttttaaat tttatatttc cataagtttttggggaacag
184621 gtggtatttg gttaaatgag taagttcttg gggaacaggt ggtatttggttacatgagta
184681 agttcttctg tgatgattta ttagattttg gtgcacccat cacctgagcagtatacactg
184741 aacccaattt gtagtctttt atccctcatc ccaatcccac cctttccccagagtccccaa
184801 agaccactgt atcattctta tgcatttccg tcctcatagc ttagcttccacttacgaatg
184861 agaacatatg atatttggtt ttccattcct gaattacttc acttagaataatagtctcca
184921 gttgtatcca ggttgctgtg aatgccaata tttctttctt tttctttttctttctttctt
184981 tttttttttt ttgagatggg atcttgctct gtcacccagg ctgtagtgcagtggcgtgat
185041 ctcggctcac tgcaaccttt acctgccagg ttcaagcgat tttcctgcctcagcctcctg
185101 agtagctggg attacaggca tgtgccacaa cacccagcta atttttgtatttttagtaga
185161 gatggggttt tgccatgttg gccaggctgg tcttgaactc ctgacttcgggtgatctgcc
185221 caccttggcc tcccaaagtg ctgggattac aggcgtaagc caccatgccaggcccaaatg
185281 ccaatatttc actccttttt atggctgagt agtattccat catgtatatataccacaatt
185341 tctttatcca ttcattgact gatggacatt tggtctggat tcatatttctgcaattgtga
185401 attctgctgc tataaacatg catgtgtaag tatccttttt gtttaatgacttcttttcct
185461 ctgggtagat accctgtagt gggattgctg ggtcaaatgg tagttctacttttagttctt
185521 taaggaatct ccaccctgtt ttccatattg gttgtactag tttacattcccaccagcagt
185581 gtagaagtgt tcccttttca ccacatccat gccaacatct attattttttgatgttttga
185641 ttatggccat tcttgcaggt gtaaggtggt attacattgt ggttttgatttccattttcc
185701 tgatcattag tgatgttgag cattttttca taagtttttt ggtcgtttgtatatcttctt
185761 ttgaaaattg tctattcatg accttagccc actttttgat aggactgtttgtatttttct
185821 tgctaatttg tttgagttct ttgtagattc tggatattag tctttgtcagatgtagagat
185881 tgtgaagacc ttctccctct ctgtgggttg tctgtttact ctgctgactgttccctttgc
185941 tgtgcagaag ctctttagtt taattaagtc ccacttattt atctttgtttttgttgcatt
186001 tgctttgggg ttcttggtca tgaagtcttt gcctaagcca atgtctagaaggttttttct
186061 gatgttatct tccagaattt ttatagtttc aagtcttaga tttaagtccttgatccattt
186121 tgagttgatt tttgtataag gtgagagatg aagatccagt tttattctcctgcatgtggc
186181 tagccaatta tcccagcaac atttgttgaa tgaatagggt gtcttttccccacattatgt
186241 ttttgtttgc tttgtcaaag atcagttggc tgtaagtatt tggatttatttctgggttct
186301 ctattctatt ccattggtct atgtgcctat ttttatacca gtagcctgctgttttggtga
186361 ccatagcctt atagtatagt ttgaaggaag gtaattggat gcttccagatttgttctttt
186421 tgcttagtct tgatttggct atgtggcctc ttttttggct ccatatgaattttagaattt
186481 tttttctagt tctatgaaga atgatggtgg tattttgatg agaattgcattgaatttgta
186541 gattacttta ggtagtatgg tcattttcac aatagtgatt ctacccaaccacattagcat
186601 ggatgtattt ccatttgttt gtgtcatctg tgatttattt cagccatgttttgtagtttt
186661 ccttgtagaa gtatttcacc tccttggtta ggtataatcc caagtacttttttttttttc
186721 ctgtggctat tgtaaaaggg gttgaatagt tgatttgatt ctcagcttggtcactgttgg
186781 taaacagcag agctactgat ttgtgtacat taattttgta tcctgaaactttgctgaatt
186841 catttattag ttccaggagc tttttggagg agtcttcagg gttttctgggtatatgatca
186901 catcatcagc aaacagtgac agtttcacct ctttaccaat ctggatgccctttatttctt
186961 tctcgtgtct gattggtctg gctagtacta tgttgaatag tagtgagagtgggcatcctc
187021 gtcttgttcc agttctcaga gggaatgctt tcaactattc cctgttcagtattatgttgg
187081 ctgtatgttt gtcatagatg gcttttatta cattgaggta cgtcccttgtatgccgattt
187141 tgctgagggt tttaatcaaa atgggatgct ggtttttgtc aaatgctttttctgtgtcta
187201 tttttttttc gggggggtgg gtgtttaaga gcagaaagtt taataggcaaaagaaagaag
187261 agaaaaccac ccccatgcag agggaggggg atcctctctt gctgcatctattgagatgat
187321 catgtcattt ctgttttaat tctgtttatg tgttgtgtca catttatttacaagtgtatg
187381 tcaaactatc cctgcatcca tggtatgaaa ttcacttgat catagtggattatctttttg
187441 atatggtgtt ggatttggtt agctagtatt ttgttaagga tttttgcatctatgttcatc
187501 agggatattg gtctgtggtt ttcttttttt gttttgttct ttcctggttttggtattagg
187561 gtgatactgg tttcatagaa tgatttaggg agtactccct ctttctctttcttgtggaat
187621 agtgtcaata ggattgaatg tctgatagaa ttcagctgtg aatctgtctggtcctggact
187681 tttttttgtt ggtaattttt aaattactat ttcaatttca ttgcttgttattggtctgtt
187741 cagggtttct aattctgatt ctagctaaat cctcctgatt taagctaggaggattgtatc
187801 tttgcaggaa tttattcatc tcttctaggt tttctagttt atgtgcataaaggtgttcat
187861 agtagccttg agtgatcttt tgtatttctg tggtgttggc tgtaatatctcctatttcat
187921 gtctaataga gcttatttgg atcttctctc ttctttgctt cattaatcttgctaatcgtc
187981 tatcaatttt atttatcttt tcgaagaacc agctttttgt tcaatttatcttttgtattt
188041 ttgttgttgt ttcaatttca tttagttctg ctctgatctt tgttatttcttttcttctac
188101 tatttgggtt tggtttgttt ttctagttcc ttgaggtgtt accttaggttgtctatttgt
188161 gctctttcag actttttggt gtaggcattt aatgctatga acttttagcaccacctttga
188221 tgtatcccag cagttttgat aggttgtgtc actattattg ttcagttcaaagaatttttt
188281 catttccatc ttgatttcat tgttgaccca acaatcattc aggagcatgtactttaattt
188341 ccatgtattt gcatggattg gaggatttct tttgatttcc aattttattccactgtggtc
188401 taagagagta cttgatacaa tttcagtttt cttaaattta ttgaaacttgttttctggcc
188461 tgtcatatgg tttatcttgg agaaagttcc atgcactgat gaatggaatgtatactctgt
188521 ggttgttggg tagaatattc tgtaaatatc tgttgggtcc atttgttctaggtatagttt
188581 taatccattg tttctttgtt gactttctgt cttgatgacc tgtctagtgctgtcagtgga
188641 gtattgaagt cccccactat tattgtgttg ctgtctatct catttctgaggtctagtagt
188701 aattgtttta taaatttggg agctccagtg ttaggtgcat atttatttaggattatgttt
188761 tcctgttgaa caaagccttt tatcatgatt tagtgtccct ctttgtattttttaactgct
188821 gttgctttaa agtttgtttt gtctgatata agaatagcta ctcctggtcacttttggtgt
188881 ccatttgcat ggaatgtaat tttccaccct tttacctcaa ctttatgtgagtccttatgt
188941 gttagttgag tctcttgaag acagcagata cttagttggt gaatactttttttttaaatt
189001 atactttaca ttctggggta catgtgtgga atgtgcaggt ttgttacataggtatacaca
189061 tgccatggtg gtttgctgca cctgtcaacc cgtcatccac attgggtatttctcctaatg
189121 ctgtccctcc cttagctccg catccccaaa caggccacag tgtgtgtacatgtgttctca
189181 ttgttcaact cccacttatg agtgagaaca tgtggtgttt agttttctgttcttgtgtta
189241 gtttgctgag aatgatggtt ttcagcttca tccgtgtccc tgcaaaagacattaactcat
189301 ccttttttat ggctgcatag tattccatgg tgtatatgtg ccacattttctttatctagt
189361 ctatcattga tgggcatttg ggttggttcc aagtctttgc tattatgaatagtgctgcag
189421 taaacatacg tgtgcatgtg tctttacagt aaaatgattt ataatcctttgggtatatac
189481 ccagtaatgg gatggctggg tcaaatggta tttctagttt cagatccttgaggaattgcc
189541 acactgtctt ccacaatggt tgaactgctt tagactccca ccaacagtgtaaaagcattc
189601 ctatttctcc acatcctctc cagcacctgt tgtttcctga ctttttaatgatcaccattc
189661 taactggcgt gagatggtat ctcattgtgg ttttgatttg catttctctaataaccagtg
189721 atgatgagcc tttttttcat atgttggttg gctgaataaa tgtcttcttttgagaaatgt
189781 ctgttcatgt cctttgccca ctttttgatg gggttgtttg atatttcttgtaaatttgtt
189841 taagttcttt gtagattctg gatattagcc ctttgtcaga tggatagattgcaaatattt
189901 tctcccattc tgtagattgc ctgtccaatc tgataatagt ttcttttcctgtgcagaagc
189961 tcttcagtgt aattagatcc catttgtaaa ttttggcttt tgttgccattgcttttggtg
190021 ttttagtcat gaagtctttg cccatgccta tgtcctgaat ggtattgcctaggttttctt
190081 ctagggtttt tacggtttta ggttttaggt ttaagtcttt aatacatcttgagttaattt
190141 ttgtataagg tgtaaggaag gaatccagtt tcagctttct gcatatggctagccagtttt
190201 cccaacacca tttattgaat agggaatcct ttccccattg tttgtttttgtcaggtttgt
190261 caaagatcag atggttgtag atgtatggcg ttatttctga ggcctctgttctgttccatt
190321 ggcctatata tctgttttgg taccagtacc atgctgtttt tgctactgtagccttgtagt
190381 ataagtttga atcaggtagt gtgatgcctc cagctttgtt ctttatgcttaggattgtct
190441 tggctatgca ggatattttt tggttccata tgaaatgtaa agtagtttttttcaagtctg
190501 tgaagaaagt caatggtagt ttgatgggga tagcattgaa cctacaaattactttgggca
190561 gtatagccat tttcacgata ttgattcttc ctatccatga acatggaatgtttttccatg
190621 tttgtgtcct ctcttatttc cttgagcagt ggtttgtagt tctccttgaagaggtccttc
190681 acatcccttg taagttagat tcctaggtat tttattcact ttgtagcaattgtgaatggg
190741 agttcactca tgatttggct ctctgtttat ctgtttttga tgtataggaatacttgtgat
190801 ttttgtacat tgattttgta tcctgagact ttgttgaagt tgctaatcagcttaaggaga
190861 ttttgggctg agacaatggg gttttctaaa tatataatca tgtcatctgcaaacagagac
190921 aatgtgactt cctcttttcc taactgaata ccctttattc ctttctcttgcctgattgcc
190981 ctggccagaa cttccaatac tatgttgaat aggagtggtg agagaagacatccttgtctt
191041 atgctggttt tcaaagggaa tgcttatgct tccagttttt gcccattcagtatgatattg
191101 gctgtggatt tgtcataaat agctcttatt attttgagat acattccttcaatacctagt
191161 ttattgagag tttttagcat gaagggctgt tgaattttgt tgaaggccttttctgcatct
191221 attgagataa tcatgtggtt tttgtgattg gttctgttta tgtgatggattacatttatt
191281 gattcgcata tgttgaacca gccttgcatc cccaggatga agccagcttgatcatgttgg
191341 ataagctttt tgatatgcta ctggattcag tttgccagta ttttattgaagatctttgca
191401 ttgatgttca tcagggatat tggcctgaaa ttttcttttt ttgttgtgtctctgccaggt
191461 tttgctatta ggatgatgct ggcctcataa aataagttaa ggaggattccctctttttat
191521 attgtttgga atagtttcag aaggaatgat accagatcct tttagtacttctggtggaat
191581 tcatctgtga atttgtctgg tcctggactt tttggttggt aggctattaattgctgcctc
191641 aatttcagaa cttgttattg gtctagtcag ggattcaact tcttcctggttcagttttag
191701 gagggtgtat gtggctagaa acttatccat ttcttctaga ttttctagtttatttgcata
191761 gaggtattta tagtattctc tgatggtagt ttgtatttct gtgggatcggcggtgatata
191821 ccctttatca ttttttattg catctacttg atttttctct cttttcttctttattagtct
191881 ggctagttgt tgatctttca aaaaagccag ctcctggatt cattgatttttttttttttt
191941 gaagggcttt ttgtatctct gtctccttca gttctgctct gctcttagttacttcttgcc
192001 ttctgttagc ttttaaattt ttttgctctt gcttctctag ttcttttaattgtgatttta
192061 gggtgtcgat tttagatctt tctttctttc tcttgtgggc ttttagtgctataaatttcc
192121 ctcaacatac tgctttcaat gtgtcccaga gattctggta cattgtttctttgttctcat
192181 tggcttcaaa gaacatcttt atttgtgcct taatttcatt atttacccagtagtcattta
192241 ggaacaggtt gttcagtttc gatgtagttg tgaagttttg agtgagtttcttaatcctga
192301 gttctaattt gattgcactg tggtctgaga gactgttatg atttccattcttttgcattt
192361 gctgaggagt gttttacttc caattacgtg gtcaatttta gaataagtgcgatgtggtgc
192421 tgagaagagt gtatattctg tttatttcgg gtggagagtt ctttagatatccattaggtc
192481 tgcttggccc agagctaagt ttaagtcctg gatatccttg ttaattttctgtctcgttga
192541 tctgtctaat attgacagtg gggtgttaaa gtctcatgct attattgtgtgagggtctaa
192601 gcctctttgt aggtctctaa ggacttgctt tatgaatctg ggtgctcctgtattgggtgc
192661 atatatattt aggatagtta gctcttcttg ttgcattgat ccctttaccattatgtaatg
192721 ctcttctttg tctttttttg atgtttgttg gtttaaagtc tgttttgtcggagactagga
192781 ttggaacctc tgcttttttt tgctgtccat ttgcttggta aatattcctccatcccttta
192841 ttttgagcct atgtgtgtct ttgcacgtca gatgggtctc ctgaatacagcacaccaatg
192901 ggtcttgact cttaatccaa tttgccagtc tgtgtctttt aattggggcatttggcccat
192961 ttacatttaa ggttaatatt gttatgtgtg atttgatcct gccattatgatgctggatgg
193021 ttattttgct cattagttga tgcgatttct tcatagcgtt gatggtctttacaatttagt
193081 atgtttttgc agcggctggt actagttgtt cctttccatg tttagtgcttccttcatgag
193141 ctcttgtaag gcaggcctgg tggtgacaaa atctctcagc atttccttgtctgtaaagga
193201 ttttatttct ccttcactta tgaagcttag tttggctgga tatgaaattctgggttgaaa
193261 attattttct ttaagaatgt tgaatattgg cactgtcttc tggcttgtagggtttctgca
193321 gagagatcta ctgttagtct gatgggcttc cctttgtggg taacccaacctttctctctg
193381 gctgccctta atattttttc tttcatttca accttggtaa atctgatgattacatgtatt
193441 ggggttgctc ttcttgagca gtatctttgt ggtgttctct gtatttcctgaatttgaatg
193501 ttggcttgcc ttgctagctt ggggaagttc tcctggataa tatcctgaagaatgttttcc
193561 aacttggttc cattctcccc atcactttca ggtacaccaa tcaaacatagatttggtctt
193621 ttcacatgat cccatatttc ctggaggttt tgttcatttc ttttcactgttttttatcta
193681 atcttgtctt cttgctttat atcattgaat tgatctccaa tctctgatagcctttcttct
193741 gcttgatcga ttcggctatt catactcgtg tatgtttcat gaagttctcgtgctgtgttt
193801 ttcagctcca tcaggtcatt tatgtcctct aaactggtta tttcagttagcaatttgtct
193861 aacctttttt caaggttctt agcttctttt cattgggtta gaacatggtcctttagctcg
193921 gaggagtttg ttattaccca ccttctaaag cctacttctg tcaattcgtcaaactcattc
193981 tccatccagt tttgttcgct tgctggcaag gagttgtgat cctttggaggagaagaggca
194041 ttctggtttt tggaatgttc agccttttcg cactggtttc tccccatcttcgtggattta
194101 tctacctttg gtctttgaag ttggtgacct tcggctgggg tctctgagtggtcctttttg
194161 ttgatgttga tactattcct ttctgtttgt tagttttcct tctaaccatcaggcccctct
194221 gctgcaggtc tgctggagtt tgctggaggt ccactccaga ccctgttcacttgggtatca
194281 ccggcagagg ctgcagaaca gcaaagattg ctacctgttc cttcctctgaaagctttgtc
194341 ccagagggac atccaccaga taccagccag agctctcctg tatgaggtgtctgtcagccc
194401 ctactgggag gtgtttccca gtcagtatac ctgggggtga gggactcacttgaggagtca
194461 ctgtgtccct tatcagagct ggaacccagt gttgggaaat ctgctgctctcttcagagct
194521 gccacacagg gctgtttaag tctgctgagg ttgcacccac aaactccccttcccccaggt
194581 gctctgtccc aggaaggtgg gggttttacc tatgagtccc tgactggggctgctggcttt
194641 ttttcagaga tgccctggcc acagaggagg gaatctagag aggcagtttgggtgcagtgt
194701 ccttactgag ctgtggtgag cttcgtccag tttgaacttc ctggcaactttgtgtacact
194761 gtgagggtaa aaccccctac tcaagcctca gcaatggcag acgtccctccccccaccaag
194821 ctcgagcatg ccagatcgag ctcagattgc tgtgctggca gcgagaatttcaagccagtg
194881 gatcttagct tgctgggctc cgtgggagtg ggacccactg agccagaccacttggctccc
194941 tggcttcagc cccctttcca ggggcgtgaa tggttctgtc tcactgacattccaggcacc
195001 actggggtat gaaaaaacaa ctcctgcggc tagctctgtg tctgcccaaacggcagccca
195061 gttttgtgtt ggaaacccag caccagggcc ctggtggcgt gggaactggagggaatctcc
195121 tggtctgcag gttgtgaaga ccatgggaaa agtgcagtat ctgggccggtgtatgtggta
195181 cagtccatag tggcttccct tggctaggag agggagttcc ctgatcccttgcacttcctg
195241 ggtgaggcaa cgccccaccc tactttggct tgccctcctt gggctgcatccactgtccaa
195301 ccagtcccaa tgaaatgaac tgggtacctc agttggaaat gcagaaatcacccaccttct
195361 gcatcgatct tgctgagagc tgcagactgg agctgttctt gttttgccatcttgccagca
195421 aatcggtgaa ttgttatgta ttctgcaatt ctatatcttt taagtggagcatttaggcca
195481 tctgcattca atgttagtat tgagatgtga ggtactattc tattcatcatactatctgtt
195541 gcctgaatac cttggttttt tatttattta cttatttatt gtatttttgttttaatgggt
195601 cttgtgagac tcatgattta gagattctgt tttgatgtgt ttccatggttcgtttcaata
195661 tttagagctc ctttcagcag ttcttatagt gctggcttgg tagtggcaaattctcttggc
195721 ctttgtctga aaaagactgt atctttcctt catttatgaa gcttaggatacaaaactgtt
195781 ggctgataat tgttttgttt aaggaggata aaaataggac cccagtcccctctagcctgt
195841 agggtttctg ctgagaaatc tgctgttact ctgatagatt ttcctttataggctacctgg
195901 tgcttttgcc tcacagctct taagattttt ccctctgtct tgactttagataacctgata
195961 actataggtt taggcaatga tctttttgca atgaatttcc caggtgttcgttgaacttct
196021 tgtatttgga tgtctacatc tccagcaagg ctgaggaagt tttcctctattattccccca
196081 aatatgtttt ccaaacttag atttctcttc ttccttaggg actccacttattcttaggtt
196141 tggtcattta acataatccc aaacttcttg gaggctttat tcattttttaaaattctttt
196201 actttccagt acattttgca tttctctgtg ttctttactt cctgaagtagtgattgtttt
196261 atatttatgc tatctatttc actgaagatt tctcccctca tatcttgtatcatatttttt
196321 tatttcctta agttggactt cacctttttc tggtgcctcc ttgattagcttactactcga
196381 ccttctgaat ttttttttct ggcaattcag ggatttcata ttggtttggatccattgctg
196441 gtgagctatt gtgatttttt gatgatgtta aagaacatta ttttgtcatattaccagaac
196501 tgtgtttctg gctccttctt atttgggtag gctatttcag aggaaagatctgaagctcaa
196561 ggctgctgtt cagattcttt tgtcccatgg ggtgttccct tgatgtagtactctccccct
196621 tttcttagga atgtggcttc ctgagagcca aactgtagtg attgttatttgtcttttgga
196681 tctagccacc cagtggagct actggtctct gggctggcac tgggggatgtctgcacagag
196741 tcctgtgatg tgaaccatct ttaggtctct cagctgtgga taccagcatctggtccagtg
196801 gaggtggcag aggagtaaaa cagactctgt gaggtgcctt agttgtagttgtttaatgca
196861 ctagttttgt gctagttggc ctcctgccag gaggtggcgc tttcaagagtacgtcagctg
196921 tggtagtata ggggaggatc aggtggtggg tgggggccct agaactcccaagaaaatatg
196981 aactttgtct ttagctacca gggtgggtag ggaaggacca tcaggtgggagcagggttag
197041 gtacgaatga cctcagactc tccttgtgtg gggcttgctg tggctgctgtggggataggg
197101 gtgtggttct caggtcaatg gagttatgtt cccaggagga ttatggctgcctctgctgtg
197161 tcatgcaggt tgtcaggaaa gtggagaaag ctgatagcct cacccagctcccatgcaacc
197221 caaaaggctg gtctcattcc cactgtgccc cctccaacag cactgagattgttttcaggc
197281 agtgggcaag tagggctgag aacttgcccc aggttaccag cctcctggttgagaaagcaa
197341 gcggggcttt tgtgccacct ccctgcctgt caccggattc acatcctcccccaagttctg
197401 gccaggaaac ttcacatttg gttggaatcg ttacagagtt cagctggaggtttccttctc
197461 cctgtggtct tttcccagtt cctctggcag ccctcctcaa ggactcctgtgagacaagtc
197521 agaaattgct tctctgggga cccggagaac ccacatggct tttcctgtggcttcttctac
197581 ccttgtgttt cactcagctc tctaaattgt ctcagctcca ggtaaggtcaaatctttctc
197641 ttgtgatctg gacctttagg ttccccagtg agtgtgtata ttcggggcaggggatgatct
197701 ccctttccca cttttgcagt ttgggcactc acagtatttg ggctgtctcccaagtcctgc
197761 aggagcaacc tgtttccttc aaatggtctg tggattctct tgactttcccagtatatttc
197821 tgcagcagtt cttggaacaa aagttcacaa tgcaagtctc cacattctattctatccatc
197881 caagtggggg ctgcaattta gtcctgactc ctatctgcca ttttttcctagcagttcatt
197941 ctggattatt tttaaccaat aactcaacca aagcacaggc cttcagttcttgtactttac
198001 aggtatcttg agtatagcaa tttttcatct gcagaatgga gagtatataggcaattaatg
198061 catctagatt ttgtccatca aaaggtaaca ttgacatccc atttttctgctattttataa
198121 gttcatacca ggtgtcaagc attatgctgt gggcaagttt cttagtctctacatccttga
198181 gtctccttac tatgaatgga gataaaagta ctactgcata aagttattgagataattaaa
198241 taagctcata gatacaagca tgtaacatgg tacctagcat aataattttctttatccctc
198301 ttaaccctcc ttcaaggtag gttttactat tttgacttta catataaggaaactgaaact
198361 ctgagaggat aaataattgt cagacaatta ataagtgata gatccacaatttaagcttgt
198421 tgtgtggaaa cttaccttgg tatgatggag gtctctaagt acactaccaagcaagctctc
198481 ccagaagtca caaacctgaa gttcacatac caaattaaaa tgctcaaatcacatggctta
198541 gtaagcttat ttaaagcaca gtgagaagta aggggaaaga gatgggttatggtaagacat
198601 gggataaagt agcaatatcg tgagatcatg ggcaacagga ccacacttctgtatcctgtg
198661 ttctgcagtg ttcgtgtgcc ctgtctctct catcctgctg atagtgtggctaaggggact
198721 gaggtcccaa tgggggccac ataataaaga ttacttgggc caatgataggtacaagctcc
198781 attggaatga atgacacagg acaagtacgc ctgatcatag cagtagcttgtgattagcct
198841 gctgaaattg caggagttgt gtctgcattt cttggacaga gcagatgcaagaggaacaaa
198901 ctggatgaca ccaatggctg gtcaagttag cagtgacagg tatctcagtcccaaagtgtc
198961 aggataatga tttggtcttt tcatctcttt ctaactgtaa tgttcttgtttgttcatcat
199021 atatattttt aaaaatttat tttctgtctt tctttggcag atattacaggttactaattt
199081 acctgctatc tgtagtgaac acatcaaaca tgcctatgca tcatatgtacatgtttactt
199141 attagctata tttaacatat cctatgtgca ggaccagcta cataatttgcatgatgtaat
199201 gtaaaatgca aatggggggc cccttgttaa aaaatactta agaatttctattattaagaa
199261 ttttaagatg atgaaagaaa ccagaatatg ccagctctaa atatgcctcattgacgtaaa
199321 tatttttgag ctgaagggaa ttaagaagca catgcagaaa agctctctgcctcttctatt
199381 tgcctaaaag caggacagag aattacaaaa acaaaaggtc ttttatgttcctcctcccct
199441 ttcctgccta aagacaagat gtaaattctc ctttacaacc tttaccagctgagagcctgc
199501 ttcagaaaaa tctgggaaca gacttgactc tttcccacag ttctctggcctttggaagct
199561 tagggctgtt ttcctctttg tcctgtcact tctctacaat gtattgatcttgttgaatac
199621 tttgtattag ctgggattct aagccacact gccttgagtt acttttcacctgcgtgatgt
199681 tcatgtatta atagacttgt ttgtttttct cttgttaatc tgtcatttgttacaggagac
199741 tgtctcaatt aaaaacttac gagggttcag aaaaattata atttcttcccaacaatgaca
199801 atagcagagc ataaaactaa gcacagggcc catgtgagta tggggtcctgtaacagtgca
199861 ggtcacaggc ctatgaaatt gcccctgcct atgaatttca cctgactattccaagccaag
199921 agctacttat tatctatgct gaacatttct aatgatttcc atcttttccaatagcagaat
199981 tcagtggtct caaataattc agccaactca cattatagaa ctcaagtctatgtaactcca
200041 agtcactgtt catgcactat agtcatggag ttctttttaa atacctgtcatccccatgtt
200101 caaacccttc aatgtctccc tagtaattaa caaaatttag tcaattttgcctaaaaaata
200161 tcggtgagct ccacaacctg aattccaact tactttccaa agcaaactctcattaattac
200221 tgatgatgac catgaggttt tggagaggga caaaaccatc tccaaatgtttttgagtgtc
200281 tcctgtgtat cgtgtcctgt actagatgtt ttacacatca actcatttaatccttatgag
200341 aacattgaaa acaaagttat ccccatttta cagatgagaa aattgagattgatagaggta
200401 aggtcacctt acacagttat taactgtgag ggtggattaa aatccagatttctctgtctc
200461 taaaacctca ggctttttct actgtgccat actacttcta atttgaactgtattttccag
200521 tgaaatgaga ttaatcttcc ctatagacat gccaggtacc tgttatcactttattctggt
200581 atccgctcca ttttttggca tcctatgctt cttccatgcc tgactttatctcccgtttga
200641 gcctctttct ctgccaacgc ccatagaaat aaaattcaaa tgaattctcttgattattca
200701 tttggctctt ctgttaggca gcattgtgtt gcatttttaa aaattatatgtaaatctcca
200761 tttcagaaga gattttgagc tcctcagggc acgaaacgta tcacatagctctttattgtc
200821 tcaagtacta gcatagtgct ttgtatgcaa tatttaatta atattttctgtgtgggtgaa
200881 aatgttaatg tcttttttgt tggacattca tttccaaagc agaacaattaacatgactgg
200941 atgtttaaag ggtctggatg aataggtgag tgaaggacag aaatgtgctggtaaaaagcc
201001 ctgatctata gtgcttgcca atttccgtgg tgtaaatact tccactatagccaattttaa
201061 gctaccaaca gttagagcca actcacaaaa ttcttgaaaa tttcataatcagtggttttg
201121 tgtgagccag cataagtcag cttcggtatc tctttgaggg atttaataatgaactcaact
201181 aaggtaaaac tgatctggaa caactgaaag cagaggttaa agtaaaataactctgttatt
201241 taatctataa tcaactatga aatgcttgaa ttagagctgc ctgtgagaaggaaaaacaat
201301 gattccataa tgtgaaggct ccagacaaag gccaaaagtg catcaatgacttcttatccc
201361 agttttttaa actaaaaaaa ctgctagcta aatgattttt gttttatatgacttttgttt
201421 tatatgactt ttgtttatat gactttcctc ccaaatctgt tagcatgcatagagtttcag
201481 tttttctttc atcttctcct cttctgctca tttctctctt tttaaattttatcataaagt
201541 ggaacacttt ttattcaaga gaaatcaatt cttgattgag atcagaaatctcttgccatt
201601 cacattagag ttgatctacc acaattgcct gcttcatcat tttcattctattggaataag
201661 tatttacagc tataaactat cctgcatctt acatatttct attaaacaagaacaatgtcc
201721 gtgacagttt tctgtctcag gatttatctt attaatattt attgtattgttatgagtgct
201781 tagcaaatta ttgtggttaa ctttaccaat gcctttcaaa taatattttgaaattttccc
201841 tgaaaggata ttgagaaaag ccaaatgtaa aaattattgt tttttttccttgggatttgc
201901 atgttttgaa aacgttctca attgttaggg aagtcagctg taaaacacaggctaaatata
201961 cttttgtcta ccaagaattc cctttacttg tctgtttcgt gatttgtttaatctttctta
202021 gttatgcatg taccatttta ccatagttac ctggagatat tcttgtctctgccttagttt
202081 ggcaggcttt tcaagtggct cactgagcta ctgtttctat ttcttttagaaagttgtgga
202141 ggcatttatt actctcataa ctgcctcaaa atctcaagca catggcctagttaaatcatc
202201 ttgaggttct gcccatatgg ttgcagaagg atattagtca ttggaaaaaatgggtctaaa
202261 atgataatat tcaaagatgt tttccaatat tcttggcaat cttattcactaatttccacg
202321 gacatttaat tagcaagaat ttaaagaacc ttgttttagt ttcctgctgctgtaatagaa
202381 tatcacagac tggataatat ataaagaaag gaaatttatt gggcttatggttctggaggc
202441 tgggaagtcc aagaggcatg acactggcac ctggcaaggg tcatccaatggtggaaggca
202501 tcacatggtg agcaaggacg agagacaggg agaaatgggg ctgtatttatctttttatca
202561 ggagcctact ctgtgatact agcccactct catggtaacc acattaatacattcatgagg
202621 atagagccct catggccgaa ttatctctta aaggtcccat ctcttactactgttacaatg
202681 gcaattaagt ttccaataca taaactttag gagacatagt caaaccatagaaatcttaaa
202741 cttcaaataa acagggattt tttttagtag cacagtataa aatgataataataaatatca
202801 gatataaaaa atttctgaag ttctttttag atagataaat catggttactattatcttct
202861 tagttacatt tcattgcacc ctattttctg tggtattatc agtcaacatattatatatag
202921 taagacacat taaattttct gagcttgcca gggcatcctg tcccctaacagtttttgata
202981 atgatttatc aaatgtgtac tctttagaat tttagctgtc agtaacagttgattttcaca
203041 acttttatta gactatccat gatgtttttt ggaaaggtag ttaaaaggataaatacatta
203101 attatcataa aattatctag gaatgctttt aaatacattt gacataatacattaacacta
203161 aaaggaaagc aaatatgcac ctaataagca caaaataaga ttaatcagagaaatgtgtcc
203221 ttgctgtttt ggggaagagt tatccagatc tcaggtaagg tactttttgtggagataacc
203281 ttctgtttta tgaagcttgt aacaagataa caatcaaggc atttttgtggccatgtttat
203341 gtatatgagc aagcaatggc aagtgagata ctagtttggg ggcttaaataagataaaagt
203401 agttaaactt tattaaaatg cacatattaa aataaatttt gaaatacattgtattcaaat
203461 attgtattag ggttctctta gacaactcat aggatacccc cacacacacattttatgtgt
203521 gtatgtatat atatatatat atatatatat atatatatat atatatatgtatatacacac
203581 acacatgcgt acatatatat acaggagttt attaagtatt aacttacatgatcacaaggt
203641 tccacaacgg ctgtctgcaa gctgaggagc aaggagagcc agtcccaaaatcaaaactga
203701 agaacttgga gtccgatatt cgagggcatg aagcatccag cacaggagaaagatgttgtc
203761 ggggaggcta ggccagtctc tcattttcag atttttctgc ttggtttatagtcactggca
203821 gctgattaga ttgtgcccac cagattaagg gtgcatctgc cttccccagcccactgactc
203881 aaatgttaat ctctctctct ttttttttga gacggagtct ggctctgtcgcccaggctgg
203941 agtgcagtgg cacgatctcg gctaactgca agctctgcct cccgggttcaagccattctc
204001 ctgcctcagc ctcccgagta cctgggacta caggtggccg ccaccatgcccggctaattt
204061 tttgtatttt tagtagagac agggtttcac tgtgttagcc aggatggtctcgatctcctg
204121 acctcgtgat ccacccgcct cagcctccca aagtgctggg attacaggcgtgagccacca
204181 cgcccggcct caaatgttaa tctcttttgg cagtacccac acagacatgcctaggattaa
204241 ttctttgtac ccctcaatcc aatcaagttg acactcagta ttaaccatcacaaatatcat
204301 aacaaatcgt gtgaaaggag gaaaggggaa tagttttaca tttcaaatataaggggtcca
204361 agattccctt ttatagttat aaaaattaga aatttttaaa tggtatgaatcacttatttc
204421 aaatagttgt atttatgatg cttttgtaat atatatgcat aagtttacctatatatttat
204481 atatgtgtgc atgtacatat aatgtataaa tacacaaagg cactcatatctacataatga
204541 tacatgattc tttggatgaa ttaactttta cattttatgc atacactcttattgtgtttc
204601 ttgaccagtg cttggtcaca gggatcagga caagttagaa gggaggctatgggaggacac
204661 tgtaaaatat taacacaact taattctgca gaaaggccag ttcacataggaagatggtgt
204721 cctctgaggg tgcacttacc caagctgtgt tccccaattg cttaggacagtcttccatgt
204781 ctaagtttgt catgtggcaa acaatcaaat ttacctggta gtcctagtgatttgcagagc
204841 tcactgaaat gccatcgttt aaaagcatca ttttaaattt attgtccactgatagatcaa
204901 aagatagaat accctattcc aagagaaaaa ctaaagactt ctattagaaaaatttaggtt
204961 tagcacttct aaatatcact atacaacatt ttgaaaaatg ttttgaaaaaacagttataa
205021 tgcttagaaa catttagaag aatataagca cacaggtatt gtgttgaaacacattaccta
205081 cactttcaat gcaggatgct tcttctcact atggggcagc actttgtgaatttttctgtt
205141 tcacagtatt cagaattcat tagaacatgt ttgattagaa tgcacatgaggcaagcaaaa
205201 ttagcacagt ctgtctatca agccacgtag atggccttgc aaagagctgaatgctagtat
205261 atctaagaat atgagattat atgtatgatt catggtggaa atgtctcctttgttagataa
205321 attcctgcaa accaatgcct ggaatgccct ctctgcctac tcgaattctattagctcttt
205381 aacatccatt tgaattctta tctcatctac aatatcttca gcaactctgaagcctccatt
205441 gtcctctccc ttttcacttc aaggctgtct tgcattgtta tgtaactatttcatgggcct
205501 agatctcatt tttcttaata aagtttaagc tgtagaaagg aattcatatatttccttgat
205561 ttcttttaaa cacttaacac attaagaaca taaaacatac ccagtaattacttaaagaaa
205621 aaaaagacta agtaaaaggg acaatgaaag aataatagaa ataaaatgaatttgtttatc
205681 agccagaatt ttgggtgggt cctcctcata gctatgtata gcaatctataatttcagtgc
205741 tatttctacc tacttctaat aaaaatattc ccacagtaaa ggggcaaggggaaattccac
205801 cattttgcaa cattttggtg attagaattg ttgagatatg gttttagacagagtttcctt
205861 cttattcttg ggctggtgat tttaagattc atttgtgtgt tttaggtcacattctcccca
205921 aatctcattt ttgctcaaca caagaacagt aagagtaagc tgggatgccttagtgatatg
205981 gcctggaact ctgcagccta cataatacta tccctacctt caggtattagtgttgctaat
206041 aacatgctca actgattcat taaaacaaag gacaaaaaaa taaacaaacataaaatcatt
206101 ttcatagagc ttaaagagac tatccagaga gacatttata aagttaccattataaaatgc
206161 ttcacactaa aaaagaattc tttacaataa tttggttgta aattgtgtaaaattcttttt
206221 ccctccatca attttagatt tattggttgg agccttgtaa gtcagactgacaaaagacag
206281 attaacaaga gaaaaacaag cagaagttta ttaccatgta tatccctcttattcatggga
206341 gatgagtaac tgaaagagga ggttagaact tgagctcaca tagcatcttaacaaaagaac
206401 agtacatttt taaagaagtg acaagacaaa ggaaaaggac tttgagtttctaggatggca
206461 aatgatggga aagcaaatat atgggggaac taatggaaaa taaggactatttagtaaagc
206521 ttgtcatgca gattcctctg gtgccctctc ttgactgata agtctggaatagtcttcagt
206581 gattaacttc tgtccttcca ggtaagaggg gaatgaaaat aatacctttatatatttatc
206641 tcctgctttt aggcaaaggg ggagagcaga gagcttttct tgtatctgctgcttcttgat
206701 tgctttcatc ttgaaataat ctttatacca tatttttggc acattttggcataatatggc
206761 acataatcct gacatggcat attttggggt gccatattct gctaccctccaaattgtctc
206821 tacccttcta ttatcttagc agataatagt acaacctccc aaattttggtttccttctgt
206881 gaggaaaaca cagtttgtgc tgtgaccagt attgtagctc ctggggaaacctgtgtggtc
206941 tcctctctct tctccctgct actgtaatac taacaaaaag aatgtttaaaccataaattg
207001 aatcttaaag caatcaagta caaatcagag ttaggaaaag ttttaatcagcaggtagaaa
207061 aaggatctag tgtgctttta tttttaaatt tttcattaat ccactaaagcccagcttgtt
207121 atttttacct tgtttcatct aaaattaccc taagatgctg gcatgacctctagggtgtga
207181 ctaaaatgtg tttgagtctt tatttgacat ttaagccagc catgaaaattagcattggtt
207241 tagagctcca gggagcaaag aagtcatcct gagtctgaag aatttctgtggctgtaactt
207301 ggaatttcat acaaatttga cctgtccaag acttgcttta attattcactaacaccagca
207361 tctggcttta acacatcttc atgagtatca tcagaactag agaaaaaaaattcccttaag
207421 aaatttttgt acataggtca ctctcatgtt tgttgctaat aaaaattttagaggtcttag
207481 taatctaaaa aatatatatt ttacctgtaa agtggtacta tccaaaaggaactataccaa
207541 aatacgtcag acataaaagt taagaggtta tgaaaatgta catgcaattctctttttgct
207601 tgttcttagt ttatttactg cttgttttca gatagtcagg tagttactctttagagatgt
207661 aaaataaagt atggacatga aaagtagtta tttaccaaag gcaattatcaagtatcaaaa
207721 catgcagagt acttactgcc agttcaggga gacaacaaaa caattatatataatatagta
207781 gctttttagc ccaatcttcc aataattgct aggccaacat gctaaatttaagagttcttt
207841 acctcttaaa tttagtagtc tcagtaaata aaatttgttt agttctgcaggggcagaaag
207901 atgtgatact ttgtccctat cataaggtca aggacaacac ttctctaatgaaagagggtt
207961 cacaagagaa aaacataaca catttcttta accaaagttt tatatgacatggaagccttc
208021 agaatgaaga tttgaagacc caaggaaaaa ctgtccattt ttatgcttagattcaataaa
208081 gtgtgaacag ccatgtagaa gtgttattag acaaacaggg aattatctaatagtaatgaa
208141 ctgagtgggg aaacccagca atacctgtcc agattcttct tggcctcactgttgtaacat
208201 ctcttcaccc tcctggctta tttggtatag ttccttttag acagtactacttcatagata
208261 aaatatatat attttgatta caaagactac aatttttgtc agcaacaaacatgagagtgt
208321 ttcttcctcc cttgacctac tgttgaccaa gactaggtca tagaatttctttatggccac
208381 cttctagaca gaaaggtaga gaaggttaga gtaataattc ttgtttttatggccggcttt
208441 ggggaaaagg gggttttagt ttctacggcc tgccctgggg aaggggaattctgaattcta
208501 tggctggttt tggggaagaa caaggggtga gaggtaggag agcaggagaaggtcagagag
208561 accttggctc tgatgctgct actgaggcct tccagtgtcc tttagttcaaggtgctcggc
208621 atgccaaagc agcacattca ggatatcatt ttctgagccc aacagttccatattctgccc
208681 ccaacttgtt gcacattgga attgttcatg gacttacaaa aatattgatgccatatccca
208741 gccctagaga ttgtgactta atttagctgt ccccaacctt tctgataccagggaccagtg
208801 tcatggatga caatttttcc atatactggg gctgggtgag gagatggtttcaggatgatt
208861 caagtgcatt acatttattc tgcacattgt aatatataat gaaataattatacaactcac
208921 cataatgtgg aatcagtggg agccctgagc ttgttttcct gcaactatacgatcccatct
208981 gggggtgatg ggacacagtg acagatcatc aggaattaga ttctcataaggagttcacaa
209041 cctagatctc tcgcatgtgc agttcacaat agggtttgca cccctatgaaaatctaatgt
209101 gactgctgat ctgacagcag gaggagctca ggtggtaata tgagttagcaatgggtagtg
209161 gctgtaaata cagatgaagc ttcactcact cgcccaccac ttgcctgctgtgtggcctgg
209221 ttcctgacaa tcatctggtc ttctcactgg tattcatttg ttcaattagcatttgttgaa
209281 attcacatct atgccaggtg ctaaacccat atctgtgcca gtggccacgacctgacagtc
209341 atctggtctt ctcactgatg tccattcatt caattagcat atgttgaaattcacatctat
209401 gccaggtgct atattaagta ctgggaaatt agtacaaaaa atatagaccttggagattcc
209461 agtgcaatgg taaaaatgga ctagaaagca acacactggg ataactactgcagaaaggtc
209521 agaggttaag tcacactacc tagggggtgg aggagattgt tggaaagaaagaaaggatca
209581 ggaaaggttt tgtggagaag ctgtagtgtt ggcctaactc tagaactgaagataaagaaa
209641 aggaagaaaa taggtgtagg agaagagaaa gggtatctta gagaaatgaaacagcatatg
209701 taaaagcctg gatgcattag aaatcaactt gcagccagcc tctcatcttatgttttctct
209761 aacttatctt gtatatcatt gttgaaacat ttttctcaca gcactgtattacacccatca
209821 atttcctgct caaaaatact ctggatcctt actaataaca gaatgaattctgcactgcag
209881 acgtgacatt agggcatgcc agatcctcct ctaaagcatt taaactgtcctcttcattgt
209941 ctatctgaag accccaggta tgttttcatc tcttcatttt tgcttatatcattcccctgc
210001 accagaatgt ccctcctact cctttgacca tgtaactgaa tcctccctttgttcagggtt
210061 ccttgatacc actccatctc tcatctcaat cttttagcat ttatgtttacttttactatt
210121 cttgtttgtt ggtaattaga tggtgcccta aatatttatc tatatctttactttttaatg
210181 aaattgtaaa ttccttacag aaaagcatag gaccacattc ctttatctctctttctgcat
210241 atggtacaat gccttaaaat aaacaaaatt tatttttatt actgataacaaaactgaatg
210301 acaataatat aatgagtttg gaaaatggag aaaccaagca tttgcataattgcctagtct
210361 ttgatcattg atgcacacta cttttacata attataatga gagtatacaaattgttctgt
210421 attctgaaat tttacttgac attgtatcat caacatttgc tatgaaaaataataaatatc
210481 agctgggcaa ggtggctgac acctataatc ccagcacttt gagaggccaaggtgggcgga
210541 tcacttgagg tcaggagttc gaaaacagcc tggccaaaag ggtgaaaccctgtttctact
210601 aaaaatacac aaaaactagc tgggtgtagt ggcacaagcc tgtagtcttagctacttggg
210661 aggctgagac atgagaatct cttgaaccca ggaggcagag gttgatttgagccaagattg
210721 caccactgca ctccagcctg ggcagacaga gtgagtctct gtctcaaaaaaaaaaaaaaa
210781 aagataaata tctttggata ataactaaaa gcatcattta cctggtgtgccaggtactgc
210841 tttgcttaca ctgtttcaac ttttgtatgt atgtccttat tccaattccatgaggtaaca
210901 ctggtgttat cctggggaaa ctgggagcac tgagctcaaa aagagtagagctgtgctact
210961 tactaggtga ccttggatac ttattttact tagcgaatcc tcagtttccttatctctgag
211021 atggggataa taatggttcc cacctttcaa gattttgagg ggatgaagtgagatgatgga
211081 cacgaatagt gcctggcaga tggccaacac tcagtgtgct ttagctcttgctgccgtcac
211141 tgttgctggt cccattttac aagtcaggaa actggatcaa aggcatttaataactctccc
211201 caaatcacac acctggtgtg tgacagagcc aggattcaaa cccctgtcccaattatgaca
211261 tgagataggg atcacagaat ttaatacgat gttgtccaag tgtaacattttacaatttag
211321 tgctacagag aacatgtgca gagttttgag agaaaacaca gttggatatctacagattat
211381 cttctgcttg gagagaaaga gaaattgaga gagatagaga gagagagattcccaggggcc
211441 cgagctctct acagcagcac agcatggctg ggtcagggct caggatagaattcctgactg
211501 cctcctccca ggcggtgtca taactggggc ttctgaagcc caacacctgggccctctcct
211561 tgggtctcaa atggagggtt gaatcctctc atgctcactt actaacaagaacaattccca
211621 ctttcaatgg ggtaacagtc tgaggggaaa tgggctaggg ttttgcctggaagtacctag
211681 ttatttctta actttgtagt ttggagattc agcataaaaa ctgaagtcagccctgttagt
211741 agtattgctg cttatacagc cgtccaccct tatcagaggg gaataccttccaaggctccc
211801 cgtggattcc taaaaccaag gatactactg aacctgattg ctgtcaatcagaacatattc
211861 ctgtttatgt cttccaccac acatttaatg ccttttctat cttaactaaccacttatcac
211921 acactgtggc cataactttt gcagtttgaa gtacaacaga aaaactagcaagaatttctt
211981 ttcccttctt cacaatttca ggaagagaag acgtcttacc atagatcttagcaacctcag
212041 catacttttt tttttctgcc ctcattaggt tgagaacttt cccttattcacttaaaggag
212101 gcactttgtg gcttctcttt ggcatatcca aattgccagc atcactaaacttatgctttg
212161 ggggcattat taagtagaat aagggttact ggaacataag cattgtgatactgtgacagt
212221 caatctgaga acccagaggg ctactaacag gaggagagtg cagactgtgtggatttgctg
212281 aacaaaggga agattcactt cccaggctgg acagcacagg atggcatgagatttcatcat
212341 gctactcagg acagcacaca atttaaaact tatgaattgt ttatttctggaattttccat
212401 taaatatttt tggactgcag ttgactactt gtaacaaact gtggaaggcaaaactgcaga
212461 taagggggaa ctactgtaat agttactgct tatactgctc ttgctatttgccatggacta
212521 agctaaacac attacataca ttattttcta taatggatgt gacaatcctacagagtagct
212581 actattatct ccattttaca gatgaagcaa ctgggcatct taaccattccagctactgcc
212641 atcagcattt gccttaggaa aaaaatgtgt tttgaataat cacttccagtatttgggatg
212701 attttcaata attctaccag cctaactatg aagttatatt atctaggaggcctctagttc
212761 ttatttttaa tctttgtacc ttcgagtagc ttcttacctc tgtaactcactcccacagta
212821 atatttcatg agaagccaga ttctctggac tattggttaa attcttttagatggcagtgt
212881 ttgttatgaa aagacttttc attcttctgg tcccttcact ggaaacagctagaaagtaca
212941 agttttgatt acagttgcct aaacaccagt tttgaaatgt ctttcatttgcttgagcaat
213001 aaatttgttg ctcaatcata ctatcaaatt gaaaacaaga ggaaaggaaagtcaacctaa
213061 cctaacccaa aaggggaaca tgtttcctgg gatgagaatg tgtcaaaggcagcatagcat
213121 gacctaacac ttctgtgtaa tcgtggttgt atcatgtgtt atgggtaaattatctattct
213181 gtaagttagt ccagtgtgtg cttcttcaac taactgtgaa agcattcttgaaagaccatg
213241 aaaccttatt attctaatta ccaacacaac ggattgataa atgaatgatgaggccaggta
213301 ttattgtcat taaatagacc tcgctcaatt atttatcaat gagtctggggttacagctca
213361 gagagctgtg catattgtag cacggtttgc ttcagctctg agacctgaagaccagattac
213421 agtcttggca ggtggctttt gttgaatgca attcaagggg gtggtacacatttgtttcag
213481 tcagacattt ggatggtttg aggccaacag atattcaaag tttatccacaaaagcctatt
213541 tcattttaac catgtagaaa aatctcttta atttattcag ataaatacaaatgagtagga
213601 gaatggatta gctgtagaaa atcatacatg taaagatgtt ttcttgcatcttagtgttct
213661 aaagactgtt ctttattttc ttagattctg ctatctgtca tggacacttcactgttctgt
213721 attgatcaat gtttatcttc atatgagatt tgtttttgta tcttctttctaattgtacaa
213781 tgaaatatgt tttctggtta agaaatacgt tatcaaggag gatagaattgggtgatacta
213841 gtttttttcc atcctgaaat catgccagct cattgcaaag gtcagccctcaaaatagtat
213901 taaggcatgc cctctccttg agtctctgat accttgcagc ccaatgtcccttcttgaagg
213961 cctgtcacct gcaagagtac tttcttacat cctatgagca tcagatatgggggaatgaag
214021 aatctcttct tgctaaacaa atattcttgg tccaccttct gccccctggctttattttaa
214081 acccatcccc aacatatctg atgagttgag tctagtaatt ctgtcttcagtgggctatgg
214141 ggagcaggga ttagctaaaa tggctgttca gggacctctt tggtataaaacttggtgggg
214201 gtgctggcag ggatctctca gagaatgaag gaggggatag agcattagagaagaaaagaa
214261 attcatacct gagattatgt aatagataat agagtctgga ctttgtttaaaaaccagaat
214321 ctaagatata tatgttgagg ctagggcggg gtagtaattg aaagagaaatatgaaactat
214381 acctagcgtc aaggaaaact aacagtaatt gaagagacaa aaataaaacttgtttatatt
214441 gttcaaagga aaatgatatt tataacatct gacaaaaact ttattaatgccatgtagaca
214501 gggttttata ttattaactg agtttataat taattttgta ctgattttaatttgactgtt
214561 accttggctt ccttctctgt ttcttaagtt ttgctagttt aatgttcacgagctcacaaa
214621 attaaaaatc ttggtagaaa tatggagtag ctatttcttt acatcctttttagaacaaag
214681 ttgtgctttc gaattgacca cttatctaga aagtgatata aatctaataagcaaaactgg
214741 atgtctttta aattatctgt taaataacta gagcagtgga gatgtcctgaaagtgagcac
214801 tttattacat atgaaaaaca aattttaatt ttactactaa gaagaatttccatttctcta
214861 tttatatgtg ttcattattc tagagattaa tatgataact cctatgtatacttagttttg
214921 tgaatttcaa aattcttgat gccaaataac tgaagtatag taaattctgccgtaacatga
214981 tgtatgggtt cctaaaaatc ccgacactat gcaaaattgg gcaataaaaacacattttac
215041 taaaaaaatg gggataggca cacaatacct agaaatatca ctagtggcacattacaaaaa
215101 atatgggaat ttagtaacaa tgacagcaat attttacaca tgttaatggttaagaaattt
215161 acaataaata tggcagttta ctttgaaaaa gacctaacgt tccctgtggaagttggcctt
215221 caaaagggtg cagcttgtga gtttttgaga agtgttggga ggagagtcgttgttgtccca
215281 gttgtgagca ggtggggctt ttctacctgt gtggggaagt gtggtagctgatggatatgg
215341 tatgtggatt ttgtgtattc ctacgctgct tggtttagct gggtgcagttttctgcattt
215401 acctggcgtt tcttgtggat agaatcacat ataagcaaat cccagacttgtgttgtgatc
215461 aaattgttcc gtaatatatc aatcatgtta gaacaaggtc acggtttcaaaaccggcatt
215521 gccgtagaat tgactgtgta ataatccctt caacacgttc acatctatgatcccaccttg
215581 ttcttgccac catcttagca agcaggggtg cgattgcctg accatttgtttgttttctgg
215641 gaaatcttga cctattaaaa gccacacagt tactgaggaa acctgtgtcagaccttgcct
215701 aggtctgtgt gagtctgagt caggtttgct ttcctctgaa aaatcagacactcatgtatg
215761 tgggacaaag agcatcagaa acatgggcaa ggtcatagag acagatcccagagactggat
215821 tagaacccaa cttgcttgat tttctgctta gaggcttcag ttcaccattttagaaagtgc
215881 ctgctggctg ccaccctccc tcctgtctta tcacctctaa aagacattgttaatgcttag
215941 acaggatgtg ttttcttcat tgcatggatc taaaaaccca gccatgagaacttagttttt
216001 aatttttgcc attgctttat tggatatttt agaatgtgca aaaggttttagaaattgttt
216061 ttcaactaat tttaccagca cagaggtcat gtcaaatgtc agggtgtttgacaacaaggc
216121 caatctagtc tatcaattga gtttcagaga agattaatga taaagggtgcaatcccaaag
216181 tctgggaatg actttgcttt caagcattaa ttattgtgga aaataaaattattagatact
216241 cccttgtcta catctacccc aaactatgtc aatcagctct atttctagaaggtttacatt
216301 tattaaacac tccctgtggt caatgcaatg gtcaatgcta tggaagttacaacaagacaa
216361 gatattgtgt ccgctatcag gaaactgatt tgggagttct gtttgatgaccgaagagagt
216421 ctttaccact gtgcctatat ttttatgcca gaatatgggt gggtgcacatgtacaggtga
216481 gtaatgaggc cccactccct agtattagtt aagttagcag gtgtgtgctgtttttttggt
216541 cactgtgtat tgcaaaattc tgagtttggc actgatacta aggaacatcttacagaaaaa
216601 attccccact gacccttctt ttttttttct ttttgaaaca gaatctcactctgttgcccc
216661 aggctagaat gcagtggcac aatcacagct cactgcaacc tccgcctcccaggttcaagt
216721 gatcctcctg cctcagcttc cccagtagct gggactacag gtacacaccaccacgcctgg
216781 tcgatttttg tatttttagt agaggcaggg tttcaccatg ttggccagggtggtctcgaa
216841 ctcctgacct caagtgatcc acccaccttg gcttcccaaa gtgctgggattacaggtatg
216901 agccactgtg cctagccaga cccttcattt ttaaaagttg actttatatgttaataggag
216961 tttaattata gtcatatgtt gaagggtctt ttctgtaaaa ccacatattccaggagccat
217021 ccaactgagg acagcattgc acttgtggaa ccacaatcca ggcttgggttatctgtttct
217081 atcatgacag aggctactcc atcacttaaa ctatatgttc tgcagcccccgagagctgaa
217141 gacaagcctg gattgcctct atttgtaatt ttcttttttg taaatttttttttggtaaat
217201 tgtttttcaa acaaacaaca aaaatgactg tcccagtcag ttcaagctgatagaacaaat
217261 ggccatagac cgggtggctt aaacaacagc catttatttc tcacagtgctagaggctgaa
217321 agtctaaaat cgaagtgcca gcatggtcgg gctctggcaa gggccttctcccaggttgca
217381 gatggctggc tccttgtgtc ttcatgtagt ggaagcaggg ctagctagctctctggccac
217441 tacttacaag ggcactaatt ccattcatga gggttctacc cccatggccaattacctcct
217501 aaatacccca cctccaaata ccatcatgtt ggagattaga tttcaacatacagattttga
217561 tagggacaaa aacattcagt ctataacaat gatcaaataa ggttacaaaaattatagtgt
217621 atgtagcatg cttgcattat gttttgatga attaatgttt tttattatgcataccaaaga
217681 aactaatgca actgctgtaa atgtataaat atttgggagt aatgttaaagtttacattta
217741 aagccctttc taaatgtgag gccgaaagta ttccttttct ctctctttctcttctcaacc
217801 ccatttactt tacagaatga tttttctgtt ttaagtcata attgctttttttttacagga
217861 ttaagtacca ggtcattaag tgtgttctat gtcagtttga cctaacctctctgccctttt
217921 cttttttcta aaggaattct ttaaaaagaa gaagaggaag tattttaaaataaacatttg
217981 actgccagaa tgtgatgtaa acttcaggtt caattctaca cttgatagaaatgaaaagaa
218041 ctagtgttct ctattttgac atttagcatc aattcccttt cagtgattccagctgattag
218101 taagtgagac taaaatatct tactcttcct ggtcagcatt taaaaatttaaacatggatt
218161 gaaaatttct aggttatgaa atacagtcta ggttcacctg tgaaggatctagaagaaata
218221 agactgcaga cctggtaaat tcaaatgtcc actacttctg tattctagtcattgcaactc
218281 acctcctttt atcccttatg ttatttttat tttctcaggg aggcaaaaaaatttgtgagt
218341 gaaaatgaag gggctcttgg gaaaggaaaa ggaaaacggt ggtttgcatttaagatgatg
218401 atggccaagg taggtatttt tatagttgtc tggtttatgg catattgcctctaagaagaa
218461 cactggttct tttctaaagg ggtgaaaaaa atcttacatt ttgtatatataaaacacaaa
218521 tactcataca gtatatacac agtatatctg tggtattgaa atttacaggggagatttaaa
218581 aaattgttct tagaagagtt aaaatgaaaa ataagtcaag aaatacagatttatggcaaa
218641 agacttactt gtgtgacttt agcacttcca aatataaaag attgcatcctttttcatttt
218701 cattctctgg aagtgaaggg gttctggtca agttgttttt ctcaaagtatctgtatagtt
218761 tttttctacc aggaacatca actatacatt ggacagaaaa taagaaaacaataaatgata
218821 tactgataca aatatagatt ttggggaaag acagaaaagc aactaacatttatttaacac
218881 ttactatgtg ccaagcactg aattgaattc ttttataaag ttatatttaattcttacagt
218941 aaagtaggaa catagatatt attatctcct ctttacaaat gttataccaactgtaagcta
219001 aatgtattcc cataaagttt tgtgaataaa gttcatatat cctaactttcatatatatat
219061 atactcacat acaatagatt aattttgtct gtttctacag tttaaataaattgaatcata
219121 tagtatctat gcatttgttt ctggcttctt tgatgcaatg ttatgttcacaagatatatc
219181 cacgttgttg tgggagttat acttcatttt tattcatgtg ttgtagtctattgtataaag
219241 atgctgtgac aatgtattta cccattctat tgtagatgga catttgggctgtttctagtt
219301 atgagtaatc tttttttttt ttgttcattt ttaaaattaa ctcatacacaattacttgtc
219361 ttctggtttg ttgaaacaat aatgcagaca tttgctacaa caatgactgttaaaatggct
219421 ggccacaaaa tctccagcaa tacattaatc tgaagggcat tcttgatgaagttgactaat
219481 tttgccattt tcatccacct tatagtattt caggacagcc agcttaaccttccttttctt
219541 atgcttattc ttctttggag tggtgtaaga cttcttcctt ttcttagcaccaccatgaag
219601 tctcaacaca agatgaagag tagactcctt ttgaatgttg tacccagacaaagcacatcc
219661 atcttccagt ttcttgccaa caaagatcag tctttgctga tcagtagaaattcctgtctt
219721 atcctagatc ttggacttcg cattttctat tgtatccaag ggttcaaactccagagtgat
219781 ggtctttccc ataagggttt ttaaagaaaa tctgtgtttt ggtggtggttccactgcaga
219841 aggcagatgg gaaaaaaagc gtgggtgatc ttttgaactt cagacttgtctcatgctatt
219901 atttagacaa tagtgcctgt ccagctccca cttcatccca gcatttgcatacatgcaaaa
219961 ttctctgcca cattctcatt cttcctggtg gtcctcttga ctatggatgacccaacattg
220021 gagttaaata gaaagaaggc cttttgcaaa atgattttat gacttgttgtcttctctttc
220081 aattaagctg accaatctgc ctctaccaga atgcagtgtc tcatgtcatacaacttacca
220141 tcttgtattg aactcaccta tttgtacaca gactatcctg gtagatcagaaggctttcaa
220201 gacaggacct ggaaataaaa gacagaaaat aaaatttatt ttgtttattatttttattat
220261 ttattttatt taattattca tattgagtcc ttcatacaat gaaaactaattaaacacata
220321 ctctgttcca atcaccctat tatgtgctaa tcccctgctt tcttattgtgttatataata
220381 aatagctgtt tctgagaggc cagcatattt tccataaaac aggggatcgataaacatttt
220441 tttgttgaat taaattggtc tggggttagt ggagaacagg gaaacaagtgaaacctactg
220501 tttccccctt tgactagaaa gtagtatttg ctgccagaga gacatttccaagcttactgc
220561 attgtaatgt tttgaggtgg gggataaaca tcttgacaaa tcaagaggttggactttact
220621 tttgtatttg actttctttt cagaaatggg caaaattcct ccgtgattttgagaacttca
220681 aagctgcgtg tgtcccatgg gaaaataaaa tcaaggctat tgaaagtaagtccttatcag
220741 atctcaggtg gagaaggttg tcttagagaa gtatctcata agcttatcagatgcctttgt
220801 cagtttctgg acttttggga agactagaaa caaacaaaca aacaaacaaaaaccaaatca
220861 acaaaaactt tgtttatgcc tgctttcgtc actgtgaaga tttgctagcacttaccaagg
220921 acaatactgg ggaccccact ctcgtgttct accttagtcc aaaacattaccattctaacc
220981 tggttttctc tcctatacag ggaagtcact attgtgcaca atgacattgaatcatcttac
221041 ttggaaggca gagattttat tttggcaatg aacatgacat tgagaatatatactctcatg
221101 aatgttagac agtaatcaaa atgaacaatg ttttaacaag tgaagaagtcttagtctggg
221161 cgcagtggtt cacgcctgta atcccagcac tttgggaggt tgaggtgtgcagatcacttg
221221 aggtcaggag ttcgagacca gcctggccag cgtggtgaat ccccgtctctactaaaagta
221281 caaaaggccg ggcgcggtgg ctcacgcctg taatcccagcactttgggaggccgaggcgg
221341 gcggatcacg aggtcaggag atcgagacca tcccggctaa aacggtgaaaccccgtctct
221401 actaaaaata caaaaaatta gccgggcgta gtggcgggcg cctgtagtcccagctacttg
221461 ggaggctgag gcaggagaat ggcgtgaacc caggaggcgg agcttgcagtgagccgagat
221521 cccgccactg cactccagcc tgggcgacag agcgagactc cgtctcacaaaaaaaaaaaa
221581 ataaaaaaaa taaaaaataa aaataaaagt acaaaaaatt agccaggcctggtgcaaaag
221641 cctgtagtcc cagctactca ggaagctgaa gcaagagaat cacttgaacccgagaggcgg
221701 aggttgcagt gagccgagat cacactactg cactccaacc tgggtgacacagccagactc
221761 tgtttcaaaa aaaaaaaaaa agaaagaaag aaagaaaaaa aacgaagtcttaaaacctca
221821 ttttcaaatc tctgaagtag aataagcaat agtcatccag gagcttgctatctgaatatt
221881 cacattgtgc ctttattttg tagaatattc ataggaagga aggaaggaaggaaggaagga
221941 gaatatagcc aatcaaaaac ctatttagtt tagtgcttta ggcttagaataaggcaagta
222001 aacattttaa aatattgtaa ataaaaatag taaattgttt tttaaaataataatctaaaa
222061 aaagggataa catttgaaac aattttgagc acaatctttc catattctggtttctaacgg
222121 tttcaactag gatctgattt ccatccattc ctctctagat tggaggcaggttttcctgct
222181 ggttaagtgt ggcgttgtat aattaaaatg gaggctccat agggagataacacagctgat
222241 ggatagcttg ctgacatgat tgggcatgtt ttaggagtgg ctaaccctcggttccctgtc
222301 tctcaatatc agatgggaat tattaagtgg caatgaatta aaatacatcagctcattaat
222361 tgtatcccct tccacacatt cccagtgcca tttctctctt gctttaatttcctccttaac
222421 acttaccgct atctaaaatg ctatatcttt aatttaattt tttgatgtaatcttaattca
222481 ttttatgttc atttctccca atagatggga aatttagttt tgttcactcctgcattccac
222541 ttggcactta ataaatatgt attgaataaa attacagaca aactcgctaaatgtctacca
222601 atctaggaaa aaaagaaagg aatttagata catcaaaaaa gagaagacatcatggatttc
222661 ttaggtttca actgtacagc tcaaatgtgg taggttgaga ggcactgaaaaacaaaaggc
222721 catttggagc attacggtcc tgatacaata tatatagtaa gaactctgaatttggtcttt
222781 gctttgctgc agattagctg tttgacttct agccagtcat ttaactcctctggacctcag
222841 tctactaatt tataaaattg tagggctgag tcttgatcag ttgttagataaatcccaaga
222901 aatttgtaat taatgatagg taaatatata catttgaaaa ttatttttaaagcacactag
222961 agcaggttcc agcctatcct aatagtaata tcatgctcat ttgtgttccaataggctata
223021 gccagtgaaa caaaaacaga cagaattatt tttattgcca gaaattgcatgcagcaagag
223081 ttacacatat gaccaccatc catcatgagt gtcacagtag aaaagacagattgagagcta
223141 tccaataata accttcagtt atctcctctc ttcttctctt cttctagtaaatttggaaag
223201 ccacgctgga aaattgaggc aaatgtagat tatttttctt tccatatataatttatgatt
223261 tgattagttt gtcatgactt cttcactgtt aatggtgctt tgtctcaactgtgaagaact
223321 gagctttatt ttttatttta tcaatattca ccacaccacc atttattgagtaccaccatg
223381 agtcagatgc tctacaaaca ttgtttcatt taatcttcag tgttcctgcaatgtgcacat
223441 taaccttcct attttatagt tgtgattaaa taactgtccc agaattagtagcagagctga
223501 aatataaggc aaaatctgtc tgggttcaaa acgtatgctt ttccatgtgttaggctgctt
223561 tctcctttag ggaaggtttt acatactttt tctttttaaa tatgttttgcaccagttcat
223621 aaaaagtatt ctacgaggcc gatggcagga tgagtagtta tagattttcttgatcgttat
223681 caaggaatta tttttcattt tctcatgtat ttacttttta gtgagtgatttatttaatta
223741 tatgttttgt attctatagg atgcttaatg tactgatttt aatgataaccatgaggcttt
223801 gggctatagt attagttgaa aaaatatgaa acctatgtaa gaatatattattagagcact
223861 ggattggact atcttataaa aagtacccta ctaaatatag gtaaagcatgtatctgtgat
223921 cacctttgaa actgaactta atgcaaaatg ggaagaaata ggacatgcaatggattttct
223981 gagttgagga ctttttgacc cctaccacct ctgtagtttg gacaatctgttgaaatctct
224041 ggttctgttt ccacatttgg ggctactaca atatctacaa catcttgggtttaactagtc
224101 actatacaag atcatttcca gctcaacatt ctatgatgtg taagttacagtcagttttac
224161 atgtatatgt aggcatgtga aattcattaa tcatactttt gattgataaatcctcaaaaa
224221 tttgaatgca aaacagattt atactaagag gggactatat aattgccttctcaaattctt
224281 tttgaaataa agttggttaa gtgtgtaccc tacttataga atacatatttaattataaaa
224341 cggatataaa tgcttttctc ttaaataaat ggccatttaa tcttacaaaaggttcagaag
224401 tatcattgta ttccatttcg acatcagaat catctaatat atatcttatttaatcctcag
224461 aataagcctg acattattga ttaactgagc aaatagtgga tgcctaacatgtttctaggc
224521 actattgcta ctgccaaaga cagcagagac tctaccctca ttgatcttacatccaaatgt
224581 gttaatgtat gtatgcttgg atggggaaga cagaatataa tataagcaaataaataatga
224641 cggtaattgt ggattgtagt aagtggcatg gtcaaaagag gagctgttgccttccattcc
224701 caacagcctt tctaatccac ttttccccac tctctgctca gtatctagataataccaaat
224761 aagtattttt aaaatgtggc taaaggagtc caaaattaac agcctttactgagttttccc
224821 aaagctctgt ccaataattt gcagaatcaa gagcgggacc caaattagagtctaaaattc
224881 atactgtttc catcttgatt ccagtaagac ctagatctct ttattagtgtgaagcggatt
224941 ctcacctgat gactcccaac tctgtttcac ttaaaaaata gatttgataattcctgccac
225001 agaggatact gtgacgttat gcatcacttg ggaatactgt ggggttttactgtcacgtca
225061 gccttaaggg gatcatgcct aaaactcgat ggttgctcct gtggacacatcttattcatc
225121 tcattgaact gtgtattttt ctgaagcaac tgcatgtttg tacccccaggaaatataatc
225181 tatacccatt gtgatgccaa cattattatt aagaccataa attaaataattgaatgtatt
225241 tctagctggg gattacaaat ttttctcagg atcaaaatct actttttcctaatagtagat
225301 tgcatcatca aaattatagt ttcagaaacc tatttttttt cagacaggaaatagctttgg
225361 ataggcaagc caaagcacag ggcttaaacc ttatgtttcc ttgctgccctaaggattcta
225421 gaaaatacaa atcaaatttg tcacatttaa ttccctaccc ctaaatagttcgaaaaaatt
225481 gtgcttcaca ttctagccta acatgatggt atttatattg tagtcacacagcaggtcatt
225541 taattggtct tttcccattt agaaatactc atatttatct gcttgtcttattacccatct
225601 attcaagagg aaatgatgtg ttatgacaga ctacaaatta ctttgccttaataataaaca
225661 accagaaaga gagttgaaat tttaacttta atttgaaaga aacaagaatattcaggaaca
225721 agaatatgct taagcataaa gcctcagttt aatacgtatc agagactctgttttttggtt
225781 gttgttgttg tttgtttgtt tgtttgtttt ttgagacaga gtcttgctctgttgcccagg
225841 ctggagtgca gtggcgcaat ctcggctcac tgcaaacctc tgcctcctgggttcaagtga
225901 ttctcctgac tcagcctcct gagtaggtgg gattacaggc tcctgccactatgcccagct
225961 aatttttgta tttttagtag agacggggtt tcaacatgtt gaccaggcaggtcttgaact
226021 cctgacctcg tgatccacct ggctcagcct cccaaagtgc tgggattacaggagtgagcc
226081 accgtgcctg gctgagactc tgtttttata cattaataat ttactatggaagcagcattt
226141 atcagtctga ttaaagaaat aagaattggt cattatgggc atcaaatttgtgaatctgac
226201 tggctttagc tgattgatgg atattatcta tacctattgt ttcagaaacacatattcatt
226261 gcatgtttat tgtatatatc atagtcttaa gaaaattaat tgaactatgttttacttaaa
226321 gggccatata gcagtgtggt taagagagat ctagatttgg agtcaaacacctgtagctca
226381 agactgcctg gtttagaagc ctggcttcct tgtttactag ctatgtagcctatagatcta
226441 agtctctgta aaatgggaaa acaatagttc ccatttcgta gggatttgatgatcattaaa
226501 taagttaata catatagatc aaattggtgt ttgaaacagt gattcactaaatgttaccta
226561 ttattaatca acttttgatt cagtcaacaa ctgtgttaaa gtttttgtttcctgattcat
226621 agtgggacta ataatactta acctcattaa gttctagtgg cagcataatgagttgatgct
226681 gataaagttc ttggaacaca taactgacca tcaagatata ctagctattattattattat
226741 tactcatttt gcttccttac actgagagat taagtatgtt aaaattgctattcttttcat
226801 ttatgctctt ttagtcacac taatcaggca tttcttttta gtgaacatcagttttagtta
226861 acaacatccg gtaggataga accactagat aaaagggata aagagggaagatttcttctt
226921 ttttgttttt gtgttgagac aggaaaaact ggagttttat gacaacttgttgtttcattt
226981 tctctacttt aagatcttca tttgttttgt tactgtgttt tctcctctgctattgatagg
227041 tctagtgtgg aagaaacttt gtcttctgga tttcttagtc tcttccacctgtgtctgggt
227101 ctttcctata atcgttctag ttttaatgaa atctattggc ctgcaattcattttctttac
227161 acttaagatt ctgtaaagac tcaacctcca aataaaatag ttgtgaagccactctcaaat
227221 ctgagaactg gagtttggaa gttttggact ctaaagtata tttcattatgatgcttaagc
227281 atgttggagg aggggatact ttctgaaaca tcttaattca cttctgtcttttgcatttaa
227341 gtatatttgt accctacacg caagaaattc atttgtcagg gattgtgtgtaggtgctgag
227401 aggatgggcc gtggcaataa ttagaaaaac aaaagcataa aaagtgaggaaggaagaaag
227461 gaatggtggg ttagtatcct atatgcggga tttcatactg gaagatcttacatgcgattc
227521 cagggaaaaa cttacattga tacctagtga ccaaggcttt cctccagtaaatgagtaact
227581 gtaatgagta acaaactgta agtccactgc cttcaataaa acatgatgagtgaacctggc
227641 tgagcagccc tcaggtagtc gttaccagag aatgtagata acggccatgaaatggtatga
227701 agtcactggg agccaagtgg gtgatcagat gtcctaggag aagcagaccagtgcacctgg
227761 tgacagtgct gggctgggct gaggtagggt ggggtggggt tgtgtatcaaaaccacacac
227821 ccttagaaac cttatagaac tctgcacccc tcggcaatgt gaaatcaatccaaattctct
227881 tgtgagcata aagaaaaata ttgacttcaa aatcattgat tttttccaaaatatccattt
227941 aaagattgac ttcttaagtt tctaaaaaaa aacctgccac tgttttacaggaataagaaa
228001 gatggtaggt aaagaataga caaaggggcc aggtgcagtggctcactcctgtaatcccag
228061 cactttggga ggctgaggcg ggtggatcac gaggtcagga gttgaagactagcctggcca
228121 acatggtgaa accctgtttc cactaaaatt acaaaaatta gccaggtgtggtggtgggtg
228181 cctgtaatcc cagctactca ggaggctgag gcaggagaat tgcttgaaactgtaaagcag
228241 aggttacagt gagccaagat tgcgccactg cactccaacctgggtgacaagggcaaaact
228301 ccatctcaaa acaaaacaaa aaaagaatag acaaaggtcc agaaatagaggtgttactgt
228361 cctgtgaggc cggcctcatc taagtaagta gaggctggaa tttgctacccatgaaccttc
228421 cttttccatt gataatgctt ccccactgat aatgtttcaa agccagaaggctccagaaaa
228481 tcattggtca atagagatgt ttagctgaat gttagctgaa tgggacagaacacatgggct
228541 gatgcagcca gggactgaag gtgtttgttg ttttttcttg ggcaactgacaatgataatt
228601 tggaagattg ggaaagctag caacttggtg ctgaatctta aatgaccgtcaaagaaactt
228661 ttgcttttgt aaatctatga aatctgaacc taagacttaa cctcttcatttttcttcttc
228721 cactctctgc tttaagaggg tgcttttttt ttctctctct cccaatgagaattaaccaat
228781 cactttactt ttcacttctg ggggcagggg tgagttgact gaacattcttgcctattgcc
228841 tattcattcc ccaaagctga agtggttttt taaaagtcat gctcatcaccccttcctctg
228901 gccctaatgc ttaacacctg tcaatgactt ctccttacat tttaaataaaattctcactc
228961 tttaccatgg gttgagaggc cccacacact gtggtttggc ctctccatccttatctgtca
229021 ccactttccc tcattcatgt actccaactg cacaggcctg agttttattcctcagtagtc
229081 ccaagccctt gccccttagg atctttgttc tggctttttc ctctgcttgagctgctcttc
229141 cccagctcag catgttgctg tcttttcttc aaacttcaga tctctgcttagatgacatct
229201 ctgatgttct ttccttgaca aaactttcta aagctacccc tttcaatactttcccttccc
229261 tcctgtagga cctgctatta tctctatctc tatctcctgt catctacatctatagctaat
229321 gtctatgtct gtatctctat ctctgtatct ttctatgtat cttacatatttgttgtatcc
229381 atacctcact aaaatgtaag ttctattata gcagcacccg tatctatgacattgtgcttc
229441 acatctaaga taatttctgg cataagatgt gtggagtgaa tgaatgaatttcagctttta
229501 taccatccct gtaaaattcc agtaatgggg gaaacagcac agaactgcttgtaagataac
229561 tatccgtaaa ggatgtggta aactcttttt gagaagaaca ttgtttgcctgagaaaagga
229621 agagaaaata gcagtaatta taattatagt gatagctaat tactagctaggcactgtagt
229681 tacctttaca tatatttgct cagttatcag tattaactca agaaataaaatgcactctgc
229741 aggtggcaat catggctgct cagcaaaagg cagctttccc ttggatggactatgatgggg
229801 taggtcacat gcagtctgca taactgcatt ctacgtacct tctacattccacatgacagg
229861 gaatgcttcc atcatgatta acattttctc ttcctgaata gagagaaaagaatgctatag
229921 cctataaata taaaaaggac caatgcctca caattaatgg attcattttgaaggcaacca
229981 agacaaagct ctttttgttt gtttgtttgc tttgatctct cttcaaactttttattttct
230041 ttgtaatagg tcagtttggc tcctcagtgg cctcatactt cctcttcttgagatggatgt
230101 atggagtcaa tatggttctc tttatcctga catttagcct catcatgttgccagaggtga
230161 gatctgactt ccagtttaca aaacatgctg aaaaatgttt ctcctagaaaagtatttatc
230221 tcttctttaa agtagaataa ttaactggct attttcacgt cttagagtcataggatttgt
230281 aatgagatta accttcaaaa tggtgcccat gggccaaagc tcccaatccttgcactaaag
230341 ggggtgtaag cctcttgaaa ttatataact tatgtataat ttcacatgtatgtttaaatg
230401 tgtattttta tgtggaaagt ttcatggctt ctttcagttt cccaagggggtccctgttcc
230461 taaatgttaa aaactattgt tcaagaggaa gactttgaca ccttgtgagttgtatttctt
230521 tattttgcca agttagcttt gaaagaaatg cttccttaat gcaactcaaagcctccagat
230581 tttctatact gaagaaacac aaaatgaaca ttttccccct aagatacaaagtaagataat
230641 gcccacaaca cacacacaca cacacacaca cacaaatagt gggatgggatgagagtggga
230701 tgggatgatg aggtccaaag tcagaaacta aaacacatag agggtccaaatcaaagaaga
230761 caaagccctg agctaatgtg gggaaagggt cagctgaggc caaaaagctagactgaggtc
230821 agagccttca ctcatatgaa gttaaatgat tctgacacct ttgaatgcttaccttacaga
230881 agttggatta ggttttagtt aacctacaaa ggacctttta ggaccagtatttcaaagcaa
230941 atttggtcca tacagcattg acagtggcca aaatttggtg gttttgggtgactttttatc
231001 ccgatagctt caaatcagtg ccagtttcta tactaagact cctattaacataataataat
231061 aataatgctt tacattcata aagagatttg agcttttaat agtacaaagcactttcactt
231121 cttttactta ctgtgcgtca caacaaattt atgatgtaga ctgtagaagacattttcttc
231181 acccatttaa aacatgtaaa tggagtcaca taatgctgat gtgacttagctaacatcttg
231241 gaatatattt ttttattaag ctgatctagg actagaaccc atgattcaatccctttctct
231301 aagattttgc actttaatcc actagtttta taatccttga gataattccagagcttctaa
231361 agttgtctgg ctcgtagaag acagtgacca aagatcagag gtcctgtgtagtttatttcc
231421 caagtgcaca ctttcaggta atgaagctga atgtgtgtat tttatctatttcaaattaac
231481 cccagctttt tttttttttt ttttttttgc ttacctttct aaggaaatctgaaactcctc
231541 cattccatca ctggctacta tgacgttact tagtgtcaga tgcaggtataaatggagttt
231601 tatcagcagc atttattctt tcccccacac catgctgcct ccatgtggagaaaatgaaag
231661 gctgttgctg atttatttga ataatacgaa attacagaat gtctgctatgtagtggatgg
231721 agtgcctacg tgttaggttg gatgtattcc aagagctagg aagcattctgtctttggata
231781 cccttttata ggttgtatta ggtgctgagg ggcatcctgt tttctgggcaatgattacca
231841 actccagcaa aagaacaaga gaatggacac cctgcatgct gactttgcagaaccaccaga
231901 ggccagggca gtcatctcct ggcagcaacg ctgtattttt cagctgcctctacccgacgg
231961 gctcactcag tattcctcca aggcaaatgc ccttttgccc caaggtcctgtgtccctggg
232021 caagcctgag accttgatct cctttgtcct ctgtgccccc gaactttggggcgagacagt
232081 gtgtctggaa cccaccttct attctgttcg gaccaggaag ccagatgggccaaaggccta
232141 ctttgggagg ttgtgcagct tgtgcacagg gagtgagcag agattgatgtccagcccttg
232201 ttcagtcaag ctctgcaccc aggcttcaag ccatattcat cttctgttcccagctttagg
232261 agggaagttt ccatctcaca gaagaagcaa catctgcttg gtaagctatgggggctagaa
232321 aggtgctctt tccagttctc accaaggcac cttcctatga ccctattcttgccctctcac
232381 tggcccactc ttcccagtac tattctccct accgtttttc tcttccaatctggtagcatg
232441 aatttgaggc agcagtcctg aattagtgat gaagcagaca ccataatcagggtgcaagtg
232501 ttctcacgtt gcagacaccc acaaattaca tgattggatt tccttgagttctctctcttg
232561 acatgaagga cagaatctcc ctccaccctc actcctaagg ggtattctcttatgaaagtg
232621 tgggtaagat tgttttgttg agtcctatgt gactcaaaag gctacctctctcctttccag
232681 acttccaagt cagaacagtt tggtggtggt ggtggcaatg gggtcctcagaaagccctct
232741 ggggaatgtg gttgacctga ctgctggtgg tcccctgaac ttggaatgcagggtcctttg
232801 cactcccttt gttcttacct ctggatttag tagtcgattc ccagaaaatgggaccccaca
232861 tggagaccca aagagtcccc ataaaaatgt ttcagaaggg cttttaaacaaaaccatttg
232921 tgatcacatg tgtggctcag actttgtttc taattgttca ctgctttctttgcttcttca
232981 tacagtacct ctggggtttg ccatatggca gtttacctag gaaaaccgttcccagagccg
233041 aagaggcatc ggcagcaaac tttggtgtgt tgtacgactt caatgtaagtgtctccacac
233101 aagtgtattg gtgggaggat ggatttttat ttagtttatt ttattctgaaacccacggcc
233161 tcctctcctg ggtcaggctg aatgtcttaa gaaagacgtc cctgctccctttaagaaaga
233221 aaggaaagaa agaaagaaag agagagagag agagggaggg agggagggagggagagagag
233281 agagagagag agagagaaag aaagaaagaa agagaaagaa agaaagaaagaaagaaacat
233341 gtccctttat ataaatgtga ctatgattta ggacaatggt aatatgattatatgggaata
233401 tagactactg gataaaggtg agctcagagt tcaaagactt gaagcaaatattcttatcac
233461 tgactttgga aaagaataaa ggaagagttt gcaaatgtgc tttttggaaaatcttgttgg
233521 attcctaggg aattaaaact tttacacttc ctattaacct ctttacttcctaaacaagcc
233581 tcctatttag tattactcaa tagttagtac taaataaagc taaatattgaaaactaagaa
233641 atactaaatt ctaactttta aataatacta aaattagtat tattccattgtagtattcaa
233701 atgagcatta ctccttgagc tcccttaggt agagattatt actatggaaaggagttattt
233761 ctgtccattg aaaaaccatt ttggactata tgattcaagt cttcgacaacaatgtaattc
233821 cacatattct ttttttaagt agtgactaga ctagaaatgt ctggaagcatatgcgtggga
233881 aagtagccag gttgaaattg aggaattgat aattcaagta atttttggaggctagacaat
233941 gagaataaaa ttttatacag attgcagaat gaaggaggga aaagcagactgcctgtttat
234001 agtgttaata tgtatatctc acaaacattt tgatttctac ttttaacctccttaaattgt
234061 gagtttccca aagaagagat caggtctgct acatcttttc agcccgtaatctagtcctca
234121 tccactacag gctaaatgaa tctcattgac tgaaaatcct gagtgagggggatgattcat
234181 agagccttga agtaagaacc acaggaccag tttatgtgag gagtaccagaacatgcaaac
234241 cttaagaaaa gtttcccatc tccgaatgaa caaagcaagc tattgagttagcatgaggca
234301 caatgatagc aacaaatatg tggcatttgt aatcttcaat cacccctgtcagttggactt
234361 tccatttcaa ttcagcattt tttaaactga attataaact tgcataggttttacaaagat
234421 gaatgtgaca tgattcttga cttcagggta ctcgtgatat tagaaggaagacacgtaagc
234481 aaccagtata caagatgctg tgcacaaagt tagcaaaatt taaaaaaaggaaaaaagatc
234541 ctggggaact gagcaagtgg ttcttatttc ttcttaggcg ggtctgggttttacagaaga
234601 gatggcctct gagttggatt ttacctctct tttctatcac ttctagattttatttctctt
234661 ttctaccact tctaacttct tccacctctt cctcctcccc tccctttatccctcccttta
234721 tttatctctc tcactttcaa atttcaaata atgcattact atgtccctttaccactgttt
234781 taatttctca ttctcttcct ctgattagca aaatgacaaa cttccagtctgcttaataag
234841 aacaaggacg aagatcactg actttttctg ttttttaagg catagcagagaaaggaagga
234901 ctaaaaatat gaacaaaagg tcttttgatt tttatatata gatttctgaagtttaaatac
234961 ttctgaattt cccaatgcac tgaaatggaa aattttgggc aaaaatgtccatttgagatt
235021 tgaaagttag tgactcagtt gaggaagaca aacagaaaag ttgctgtaagagagttacta
235081 atgagtggac aagagggtct gagaggcaaa ttcaggggaa agtagagggaaagggtttgg
235141 atgatgagtg tgcttcccaa gattgtatca ctgcccttga cagctctctcacatccagtt
235201 tggtgaaata tgatttgtcg gtcagcaggg gatacagaaa ccagagtgttctatgatagt
235261 tatttcaagg cctgcctgaa aacaatacta aggcaatgag agaaattttaaaggtcaaga
235321 aaatataaga aagccattac actgatttta ttcacttaca ggcttgctgcatgctggtat
235381 cagtcattaa tttggtatgc atcattgctg gggttagtag tgattttaatagctgtattt
235441 ctccaatgtc tgcatcatgc agtgaactgt gattggtaag taaggtccctcacttcacaa
235501 cccacttcat ggtgggtatt tatatctgag actaagctcg agtgttcttatatgtgaaat
235561 ggagaaaata atagtatcta cctcaaaaag catcaagtga gataatgcatgaaatagcag
235621 atagctcaga gtatgtagca cacagtacag gctgagtatt ccttatccaaaatgcttgag
235681 accagaagtg tttcatattt caaatttttt cagattttgg catatttccgtatacataat
235741 gagatatctt gaagatgaca ttgaagtcta aacacaacat tcatttagtttcatatacac
235801 ctgtacatat agcctgaaag tgattttatc caatatttta agtagccttgttcatgaaac
235861 aaagatttga tggtgttttg actgtgacct gtcacgtgag gtgaggtgtggaatttttca
235921 cttgtggcat catatcggtg ctcgaaacat ttcatatctt ggagcatttaagagtttaga
235981 ttttttttta ttaggaatgc tcaatttcta aatattcctt attacaagaaccataacttg
236041 accaaaggca aacagctatt aggaaaccga attgggatgc agggctggtggtattacaca
236101 cggtaatgta tgtggatagt ggcaagctag taaaaggact tttattataacaaagaagta
236161 aatacataag taaataaaag tattctgacc ttaatgagga gttcttgaaagattcaagga
236221 aaggaagcaa taggattata tagtcattat caaattgttc attgaataacattattattt
236281 aaaagaaaat aatactgctt taaggaattt tatatgatat acaagttttcatgacttttg
236341 aagtttgaaa gatttgtctt ttgttttggc aatgattata ttctaaattcagcaggaaag
236401 ataggttgat tcatattaag ggacactttg cttttacatt tttgtaagaaaaaggaattc
236461 agcccatcct acaataagct aataattgag cacattctct atactagggtcaaaataatt
236521 tcacaagtac atcaataaga gagagggaag gacctttaat tattaaactgaagataacaa
236581 caagaaaaaa atgtacaaag cttaatttaa aatataggag atttggtttcacagtaaaaa
236641 tccaaaagaa taaagccaag tagtcactgg taataagaca ttatagattcaaatgagatg
236701 ctgtcttggt caggacgtgg tgtcctccac ggcagaaggg aagaggctgcctgagcacag
236761 attgtcttga gtatcgtgca tagatggtag agatcagacg ccacagacagccgtgggctg
236821 tccctttaag aactcccata gaatgggcag agatgtccta gaattggacaataaggaaag
236881 agtacaagga aggaaaaata aaatctagcc aagctcaagg acctgtatgtgttacctcag
236941 gttaaccaga cgtttctcag aagacagaat ctaaatttct acttacattgcttttgtttt
237001 tattatcatt tttgtgaata ataccaaaat taatgtagac taagtacttatatgggcagg
237061 cactgtgctt agtgctatga tatttctatt tatttatgaa tattatactcatatatttat
237121 agtgatttat actacttgtt tcagtatgca tcaagaaatg gaaggcacagatatcttgac
237181 agagataatt taatataaga aattaaacag gtattgggtg actaaaaaggcaaaagggga
237241 cattgaggta acatagaaat ggtaacaggt aacacagacc agtttttacccctactgttg
237301 ggagaacaaa agaggaagtg gggttattag aatctagggg cttggaggaagggcgctgca
237361 tggccccaag aggtgtgatg agattggttt tgagtgtgct cgaacagactggaaatggaa
237421 ccaaataccg ttaccagagt gaagaggcat tgctggagcc atgcattcaggagagagcaa
237481 atcccttctc ctgacttttt gtctaagtgc ctcctatagg aaaaatctgcaaggaatccg
237541 atctcaaagg aaaaaagtag ctccccaagt cccgtctcca gcatcacaaagcagcatata
237601 caaggatggg tctgaagctg aaacagctta ctaactggca cattattctatttatattat
237661 gacctattcc tcttcctagt ccagtaaggt agatatgact attcctaatttacagatgga
237721 gagactgagt tttagtagga tttggtattt tcctccaagt tccgtggatggcaagtggag
237781 aggctgggat gctcatctgg tctgcctgac atctctgtct gactctgaagcctaggacaa
237841 gctgcctcta cataggctac taggagccac tgagatggct acaggtttatactggaaatt
237901 cacaaaaata agagaatttt agaaatagag gtgctcttcg atatcttccatcctatatct
237961 taccttataa agttacagaa attttgagtt actgaagcat gttcagggtcttatagttgt
238021 taagaggctc ctaatctagt gttctcttca tgtcctgtat tccgcccgtaattttcctgt
238081 tgtaatttcc agcaacattc tcactgactg ctcctggaac atttactgactctgtttcat
238141 gatatatcta tttcacaagg ggaaatggag ttgaagcatt tgggccccattttaatcttt
238201 cataataatc ttgtaattcc caaatcagct tctcaaatag aatgagagctttcatgtttt
238261 tttttcctaa attctttttg tatcatttaa atattatgct ttattaaaatattcataatg
238321 gaaaatcata ctttgaaaat tgttattatt aattttgctt tggttggttagcaaagttct
238381 atctttagtt tttaaaatta atttattttt gaaatagaca ataaaaatcgtatatttgca
238441 tgagttcttt gcttgatcct ctgaacaatg acttcataga ggtgctcactctgtattgtc
238501 agatgatcta agtatacaac ccagtataca acccagtatt ccatctatcatggcaccatg
238561 gaggaaatca ttgacaaaat gtttttaaac tccttaaaaa ttcataatcctgacttttgc
238621 aaagcccagg ggtgccaaag caggcatccc tgggcttttg aaaaatgccattatttaagc
238681 tagagccgtt atctaggcta tcattatcta ggtagagttt ggggtgtgtgtgacctcaat
238741 atgaaaacat ttggatccac tctcttggat ccaaagagat ggcatctggaggctgtctct
238801 caaaggagat ctgagcagca cacccagcaa caggatcagc tgaccttggacagactatat
238861 agaggtaagt tattccacat agaggcaggt gaacagaagc agaatagatttaagatctgc
238921 acttacagaa taatgtaaga taaacacaag catgatctct tatggtacaggagcctattg
238981 gatgggaagg atcagaaaat ctttggggta aggtagggga ggttgtgaggaactaccaat
239041 ctgtagagct tcatctggga accttggaac ctcctctcca tacccatgaaagcgcagtgc
239101 tctgtgactt agatgtatat atcacaactc atccaaattc tcttcagttaatagtagaca
239161 aacaccatac acaacatgca tgatcagcta gtctcagggc ttttcaaagtcagaatttac
239221 catttatgaa acactgtatt tttaaaatat tcttattgag tgcataatgatacatcttac
239281 tgatggtgct ggaaatctgt tttattaaaa tagtaagaaa cagagagattattatgtatg
239341 caatgaatca aataagcaga aattgtatca tgtaaattaa tagaagcagaagaatgagtt
239401 taagtcagta ggaagaggat gtctttgttg gcaagatacc tggagagacaagggtgatat
239461 agaaatgata aagaagaaaa ggctacacag ttttaatatt cttgtgaggagaaagaagga
239521 ggaactaaag tggaatttgg aaggagcttc agctgatatc agacagtgagatcatatggg
239581 taaaggttta agttgtgagt aaagggaaat gcattctgct tttcaccttgagagcatctt
239641 gtacattgct gatggataaa tggtatgtct actttgcctc cccttttctgctgattatca
239701 tagatgtggg agatagaaga tatcctacaa tgggcaggag aggagacttaacacctatta
239761 tgtgttaagt aggtacatac attaaatttt atcctcataa caactgtttaagatggaata
239821 tatcatccca gattattcct tctgccctgc ctgcctcaca tcccatcttggaggtttgtc
239881 cttaaaggag acaggttaga cacatataga atgttaataa aaaggagataagttctttaa
239941 tcaacatcaa caactctttt cagtaataat gttccaaagt aaaggtgtcttctctcaaac
240001 atatctcagt tctcttaagt tccttcatct cttattgcac tggacacaggtagaggagat
240061 attttgtgat tcacacgtgg aataacacat cttttgtttt agaactatttcagtggttcg
240121 aatgcatctt tatttgaaaa ggtgaatcat tttaggtttc ctgaggtgtagacatcaaaa
240181 ttatgttaca tgcaggagat attgggggag ggaggcgtgt gaaggataaaggagagagtg
240241 aacaagagta gacaggaaga gcttttagat ggtaatgcag gccctatacctgtgaaagga
240301 gagagaaaag gaaggattta ggaagagtct cagattgtac tacagttttgaaagagtctt
240361 ggccaggcta acggtgagtc tctaaacaaa gtatgtccat tagataaattccatattggt
240421 tagcaataac ccagctccag tatttcccat catgctcagt cattatctaggtagtggttg
240481 gggtttgtgt gacctcaatg tgaaaacagt ttggtccact ctggtgggtccaaggaggtg
240541 gcatctggag gctctctctc aaaggagagc tgagcagcac gcccagctgctaccttgaaa
240601 atgtgactgg gctcctccac tttagatcat agctgttcat attgctgttgttgctgttat
240661 ttagtttcaa caggtttcaa atgcagccag aatgacctgt ttcccacatccatcgtctgg
240721 gcctacctcc gtgctgggtc agcagaggct gaacttctag atcatgaataattcttcggt
240781 ggcatgaccc caagcgagac tgctaagcct cttgtggaca aatttagagttataaatttt
240841 caaatccacc tagagatacg tctctttccc tagtagcaga gatcataactttggaggggg
240901 tgaggaccct ctcatctgtg gatgtagtga gattcctcca atggctttgctgagcagggt
240961 gggctgctgc tcaggcatgt aacgctggga ctggcagtat caaagggctctgtcccttat
241021 ttacttcact tcctcaatgt ccagtgtggg tctctttggt tcaacaggcttattaagttt
241081 gattaaaaga agatgcattt catgttctat tctaggtcct agatcacttcttttgctttg
241141 taagcttctt aatttgctac tcctgagtga ctttatgaca cagctctagcttgtgacgag
241201 agagattcct gggtctgctt ttagcttcct tggtatttta aacttggggaactgatttct
241261 taaggtctga agtcctagcg atgccttttt tttttttttt tttttttgctttagtaacac
241321 attttagttt tcatcacctc cctcaggcta cacttggcca aaccaaaagtgagcttttct
241381 tttgcaaata ttagggatgc atatgatcct aatgctatac ttacaatatgaaaacagcat
241441 tccttctttg gaagtgacca tagaaatgag tcttcttttc attaacatagtaaacatttg
241501 ttgggcattt gccaggtgcc aggcattaag caaagatgag aaaacccaaggtctctgtcc
241561 tcaggaacat aaagtccgag ggagtagtca aataatcaca aaaataaatccaactgtaat
241621 tgtgccaagt gctatgaagg aaagctatat agtgttaaga gaacttatagaagacaacct
241681 gatgtggttt aggagctaaa ggaaggagac agataaaaga aaatatttttctctgagaaa
241741 gtaatgttca aattgggctc taaggagtca ggacaacctc tgaatttgaaagaagggaga
241801 gatattctca gcagtaagaa catcaattac agagaacgtg tgatgataagaggtggcctt
241861 attcagggga ctgagtaaaa cgagagagct cagaatgtga agggacatcagaacacaagg
241921 cattggagag acagaaggga accaaagcac gtgggatcct ctaaaatctagactgcacta
241981 attatttttt ttttttctca gagcaattaa aagtaactta agtggggggtaggtgggtag
242041 taacatatca gacttggatt ttgaggtaat caacagactg tagacgggcaagatggctgt
242101 gaggagatca aggaagaatc tttcgatatg actaggttag agactaaggttggaagagct
242161 aaatttacct ggcaggaatt ttctatatct aaatattggc tgccaaactaatagattaaa
242221 ggatgagcca ttgagttagg ttagaacttc acaatgcatt aaattatagtcaataattta
242281 aacacatagc accaaatcat aaatctaata catctgtggt gacaagtagattatgtaaat
242341 ctacattcat ttttttccaa gtagctgcaa tatattcttt acattttaaattattttatt
242401 tgttcaaaaa ctccttttta aatacataat accaaggcat ctcccagtataggctgtgtc
242461 cagatgacca cacacgtctc gtttcatgta tgaattcaca aagcttcactctgaatattt
242521 taaagaacca gcagcaaatt tataactcca gaagtcaacc agccaacaaaaccctctaat
242581 atgcttttaa tctcctcctt gcgaaatgaa agaagacaac ttttttttctttgtggaaag
242641 aaattataca taaaagctca ttttatagca ctgagactgt ctcattttgttaagagtttt
242701 atgcaattag acagtaggaa aaattaaaga gtttttccag tttcagtgtctctcagacac
242761 ttctttggtg ttttgattca ttaaatccca acataagatt attattgccacgttactgtc
242821 ttggatgatt tactctattt tattaaaatg ggtagcagag agcagaagaataaaaaaagt
242881 tggtgtacat gacaatttaa aggagcttat tctaactgag gattgctaatgattaccaga
242941 agcaattttt ttttgttcat tcaatcactc cacaaatata aattgaagtcagatgttggg
243001 aatacaaaga caactaacat atattccctg cccacaggga cattatgatctaattggata
243061 tgcaaacaaa caattgccat gcaaaatgac aatctgaggc tgatgtacatatgtcttagg
243121 cacttgggaa cataatggaa taagggttca gtgtccgggt taactggcattcagatactg
243181 gactcttgag agagcccagt aaagagaacc tctatttccc atgtgagttctgaataattt
243241 gtttaaaaag aagaggcaga tgggcaaaaa atttttccac attcattattaatggaaatc
243301 gaattggagg aacaatccgg aattcttagc caaatggtct tgctgatttagaaccccaaa
243361 ttagccattt tacctctagg gcaacttatt tcctagaaga agaaagatatgtttgggctg
243421 ggccagccca gttaattctt tcccagttta ccaacagaaa tcactatgcctttcctggtg
243481 tgcagtgagt atagggacag agaaaagctg aggcatattg catcaagtgaagctccgtgc
243541 ctctgaagga aatgctgaga gaaaggaagg ggcattcatt acccctatcacaactggctg
243601 tggttgagag gtcaacaaag gctttacaag tatcttgaac cagctttaaagaaagagtag
243661 gaatagagca ggctctagaa tggggcaggc aattgggaag cgaattccaagcagagagat
243721 cggcatgcac aaaggcatgg aggcatgaga tagtgctatg ctctcaacacccaagagtga
243781 ttcagcaaag ttcatattta gggagaaagg agggcagcaa gaggtgagcctgtcatacta
243841 aaaaaaaaaa aaaaaattca aaaaagagcc tgatcaggga gagaatttcattatgctcaa
243901 gtcagacttt atcctatagg cagcggagcg cacctgagat aggaggaaggagcaggtttg
243961 gggaattttc ttgaatgtgc tatgttcatg cttcctatga gacatgcaagtggagtgaga
244021 tgtgtaatgg cattgggcat agggtctaga attcccactg ttagtgtcagtcgtgggcca
244081 tggcacaaaa ggcaaatgga agtactttct atagaagcca gaagagttaaaaatgcagtg
244141 tagcataatg acaaaaacta ggcatgagat tccaacaaac ctgggtttgaatcctgccac
244201 atacgaccta tgagatatta gacaatcatc ctgaaccttg tagttgccatgtataaaaca
244261 gcagtattaa tacctagcta ccaggcttgt ataaaaaata catgagattatgtgtgtaaa
244321 gtattagcac atctcggctg ggcgtggtgg ctcacacctg taatcccagcactttgggag
244381 gccgaggtgg gtggatcaca aggtcaggag atcgagacca tcctggctaacatggtgaaa
244441 ccccgtctct actaaaaata caaaaaatta gctgggcgtg gtggcgggtgcctgtagtcc
244501 cagctactcg ggaggctgag tcagaagaat ggcatgaacc caggaggcggagcttgcagt
244561 gagccgaaat tgcgccactg cactccagcc tgggtgacac ggtgagactctgtctcaaaa
244621 aaaaaaaaaa aaaagtatta gcatggctct ggcacatagt agattcttctttaaatgcct
244681 cttcaggata cttagctcat gaaaattccc atttgttgga gggacaaggaaacagaagga
244741 aggaacttgt agccagagca agaaagtgga agtggggcag cagccatgtcccctgtgtag
244801 gcaggaggca gggggacaag agtaccaatg caaggatgga gggatggatacccaaaggaa
244861 ctgcctcatt cacagctgct tgaggggcag agatcactgt ctacagtccttaacacaact
244921 tgattccctc tgctgaaaat tagatctgcc taggctcagc tcagcttcctctttgtactc
244981 cacactgtct ctgttaagaa ccatagagca cctgtttcat gtctatgaatctgggttgga
245041 gcaaaaggaa aataaaataa aaaaaactca gagatgagca aagtattaggcagaagccta
245101 atgggtctgg ctggagagga ggagtgtggc catgcgctgc tgtcagcatgcagctcacaa
245161 ggcccgggct ggctgctgtt cttgtgacgt tagttgaggt ttattctgggcataattagc
245221 cttttcactc cttgtttctt tcctgtgttg cgtcctactc catgaaatgttgagtgccag
245281 tccttgtctt tcatccacac ttgaaacctt cgttcatgct aaggtgtaaataaccagcaa
245341 caactcagag aaaagtagaa atacacccag acttgaatct tgcagtgtcacctcccctca
245401 cataccctca gcagatatgc ttaaaaaatt atatcttcct ttcctaccagttttacttta
245461 tacattcttt caaaataatg gtctggcagc tattacaaat taaaaagagttactaagaat
245521 gaagaaattc aatgatcatc ctggggatag agtgttatct ttcatggtgaacatttcttg
245581 gtaatcatga gaaacaccaa agggatgcag ttttaatata atttcaggcaacaaataatt
245641 atgaaggaga tgttttgcat gcagagcctt ttggggacct ctgaaatcctgtctcctaat
245701 ccatctatgt atattgggca aatagtaagt tctcaataag tgttagttagaaaagtaaat
245761 gcatgaattg agtcctggta accataataa aaacagtctt tcttgtggaaatgtgttggt
245821 gattatggac tggaccagct gcagcaatca aacagaaatt agagtcttaatagacaacac
245881 acgagcatgg caccccagag ttggacagaa attttctgtg ctcactgggaacttggctct
245941 gactctggtt tctctgtcac agattttggg gtgggagagt gctcccatggggaaagcagc
246001 acgtgctgat atcgaaattg aatagaacct tggctgggct aggagtcattgctattttag
246061 tcacttccag atgtctgctg ctgtagtttt aagggacagg gaaagatgagtggagtgtgg
246121 catgccactg ggtaaaagat gaggagcgtt ctccttctaa gcccttcaagttgtatttaa
246181 agccatccct caatatgcta caaagatgga ttggataaag cctttaaaaactgtgttctt
246241 ctattcacaa tagcaaagac ttggaaccaa cccaaatgcc catcaatgatagactggata
246301 aagaaaatgt ggcacatata caccatggca tactatgtag ccataaaaaaggatgggttc
246361 atgtcctttg cagggacatg gatgaagctg gaaaccatca ttctcagcaaactaacacag
246421 gaacagaaaa ccaaacacca catgttctca ctcataagtg ggagttgaacaatgagaacg
246481 catggacaca aggaagggaa catcacacac tggggcctgt tggggggttgggggctaggg
246541 gagggatagc attagaagga atacctaatg tagtgacagg ttgatgggtgcagcaaacca
246601 ccatggcata tgtataccta tgtaacaaac ctgcacattc tgcacatgtaccccagaact
246661 taaagtataa taaaaagtta attaattaaa aataaataaa caaaaactgtgctttttaac
246721 attcatttat agatttgact tcatatatat caaataggca aactgcagaaacctttgtga
246781 actaatcatg actctgcctg ccccaactag aaaaacaaaa caacacaaaacaaaacaaaa
246841 ccagaaccat tcttgggctt tggttatgat ctagtattta tgaagtgccagccattaaac
246901 atatgttgaa tggtacctat gccagatgag ctggctgccc ccagtagctattgtgctaac
246961 ctaacaagct caccagatgc ttgttctata tctgctttct ccttttatgatattttcggt
247021 gtgtctttta atcccaaaat tgtcattatg aattagataa aagatatcaggtggggggtg
247081 accccctctg aaatattctc aaaagggatg cctggggttc tttccaagaggccctgtcac
247141 caccagggac cagtctaggg tatagatcaa agtctgtgat gggttcatagagtttcttgt
247201 ttctttcctt tctttcactg agaaggtatg gcactagcat gatataactcttgctggata
247261 aagaaagcac aggagaagca gtatagtgca gtggttaagc atataggatttggattagac
247321 tcaggtcaag ttcagacact gtcactcatt agtcatgtga acttggacaaattacttaac
247381 ctctctaagg ctcagtttct tcatctgtaa aataggtata gtgatagcagctattgaatt
247441 tttgtgtgtg caggagaggg gaaaattatg gtaaataata attcctcccttgtccaacaa
247501 gattgtgagc tcaccggaaa tataacaaag ggtaagacca gtgaaggtcaacatgccgcc
247561 tttattattg ttaaagctga cataaaagaa tgtagtgtct ttatggacaagtgaacttca
247621 cagccagacc tctctgccag gacaggcctc tccttgcagg agcagagcacagcatgttcc
247681 ctctcaagag aaggaagaga tgtccgcatg tctccatcca tgctctactgtcaaatcagt
247741 cacttttccc cgaggctaga gtgaggcagt ggagggtggc tgggagtgttatgttaatgg
247801 gtcttcactt ggaagggaac gtcaagagtt ggagatacga ttaccctagtagcagcaact
247861 tcatagtgtt ctcctgagga ttctgtgaga taaaataagg tgtttggcaagtgctaaatg
247921 ttcacgaaat gtatacggtg atgttacttg tcacagcaac cattatcactgagtgtcaca
247981 tctgtggcaa ggaaataggg caatgaaaaa cagagacatt tggaagttgtggtgttgtcc
248041 catgagggtt aaataaagag ttcaggatat aatctttaaa ccaaacaagagattaagtgt
248101 ctatacttag catgttctgt tattgtcacc ctgggacaga ggaacaagcatgaaggttta
248161 agacatgata gaaggagatt ggatttaaca caagtgggaa gaagcagagatcttaactag
248221 ataaatgtga aacaagaaga tgtcatgcac ctgggagctg ggagatcctcccaagcatat
248281 tctcctggga tgaagatttc tgggtcttgg ggagttggtc aatccatgtcttatcttaga
248341 catgagatta gctcacccac tccctctgct tgaggtttct actagctgtttatccccaaa
248401 tgttctgttg gatggcatcc tagtcagggt tctccagaga aatataaccagtagaagata
248461 tgtatacaca catacacaca tatacatata tatatatata aaatttattatatcaatcta
248521 gtatttatat aataaattta ttttgattta tcattattat tacttaaatttattatataa
248581 atctttatat atatatatat gcatataaaa tttgttgggt ttttttttttttttttgaga
248641 cggggtctca ctttgtcacc taggctgcag tgcaatggtg tgatcttgggacactgcaac
248701 ctccacctcc tgggttctag caattctcct gcctcagcct cccaaagtgctagaattaca
248761 ggtgtgagtc accatgtctg gctgatatat ataatttata agttaatataaataatagat
248821 ttactacaga tataaaagga gattcatttt gaggaatagg ctcacacaaccatggaggct
248881 gagaaatctt ctaacctgac atctgcaagc tggagatcca gagaaaccagtgctgtaatt
248941 cagtctgaat ctgaaggcct gagaaccagg ggagccaatg gtgtgaatcccactctgagg
249001 gcaggaggag atgagatgtc ccagctcaag cagtgagtga ggcaggagaaaaaggagcaa
249061 atccctcctt cttccttttg ttcttcctct ttttgtcctc agtggattaaatgatgtcca
249121 gccatgctgg ggagggcaat ctactttact gagtccacct atttaactgctcatcttatc
249181 cagggacacc ctcccgggca tacccagaaa cagtgtttga tatggacaccccatggccca
249241 ctcaagttgg cacatacaat taaacatcac aagttggctt tattttttcttaaactgaaa
249301 aatgcagata caggcctgtg tggcccaggg aaacccagac ctttggtatttacctgtgat
249361 tcattccgtg cagtcccgag ttaagcacac aagttcctct gagattatttggagatttta
249421 ttttgttcta gttcttaaag agtacaatat ttaagaaaat ttgccccatattttgaaagc
249481 aatagttttt cagatctctg ttggcctctg atttgagtta ggcatgatgtttgtttaagg
249541 caattttcta aattacttct cttaattctt cctctaggaa ttagcatctacgacatttct
249601 actttctttt ccacacctcc actctccccc acttcacttc ccttcttcagctgtgagtgt
249661 caaagtccct gggttcgtat aaatgatgtc aaaggcaacc aattgggttttctaagattc
249721 agggttgact cacctgatct caagaggaag ccccatattg acaagtgattatcttctcat
249781 ttcacaaaac atagttattg tcagagagaa gtaagagggg agctggggagtggatagctg
249841 tagtgataca gtaacagtgc ttcaatgctg aaagtgaaaa acacagtgaatgtgaggaag
249901 agaaaaggtg catattataa aggaagcagc atcagaatat gccaatgttctgagaataaa
249961 gagggagtta ttcaggtggc tttgagagag ggtgatttca accctggcagataattttta
250021 ggaacgagaa tctaatgcac aagtaaacat gcttgttata tgggaatgctgtgatagtct
250081 tgatgaatgg gaagtgtgca gatgagttcc aatgtcatcc cacctgctctttgatatttg
250141 tgaagtgaga gctgagacat aacctctgtg gtttaagaag aactgatctaattatggtca
250201 ggtgattgga aatggaaatc tgccacagca ctttgaggaa gcatttttcagatccccatc
250261 ccctagtatt aagcaaactc ttaaaatcgt aaatctaatg ataccacgaaatgtgttttg
250321 atgtttaaat caaagggcat ttcacggtaa tggctccaca gctgagcaagcctgtatttg
250381 cttaaaaatt ttatctattt agaagtcact gattttcaaa taaactgaaaagctgccaat
250441 caacatggca gctgaaacat tcactttatg gagcaaaaca atagggctcatgtcagagct
250501 gtgacccaag tttgaaaatt aatgtcattt tgttatttct cttaagagttgatcttttcc
250561 tttgagttgc tcttcacgac aactgctaag tggctttgtt gttggatttcagggtttggc
250621 acaatattcc gttctctttt atggctatta tgacaataaa cgaacaattggatggatgaa
250681 tttcaggttg ccgctctcct attttctagt ggggattatg tgcattggatacagctttct
250741 ggttgtcctc aaagcgtaag tttcatttgt cttttgggaa gcaaataatgatttctggaa
250801 tcaaatggag ggattaattt ggggattgga tataattttg ttgctattttatgtctaaag
250861 gaaacagagt ctgtaagaga tgaaatgtag ttttaatacc aacactaatgttagactatt
250921 acatcttcaa aagaactgaa cataaacaca ggcctttgag tcatctcatggggtcagacc
250981 aatgcttgca tgcctatctt gtgtttaaac atatttttta aatgtgtatttttgtacttg
251041 aaggtgtgaa ttaatgttgc cagcaagaca ggaaaacagc tgctggtctctcttttgcgt
251101 gcagagaggt ttgtaacttg cagaatcagc tcaataggca gaatctattgttctctgctc
251161 attttttaaa aaaaccagaa taatcactca ttcaaaaaat tttagctgtgtaagacagca
251221 aaaatgaatg gtccccaatg aaaccatcac aatcaactgt ataatcatggtttgtcttgg
251281 gaaaagattt attggagtat ggggaagaat ttcactggag aactgatattactgcagttc
251341 atttttctcc ctgcctaaaa ttatttataa tactccactt aaagactgcagaagcctagc
251401 agagttattt gggtttatat attaaaaaaa tgacccttta gccaattttttttgaactag
251461 tttacgagaa gagttgaaac atctcaagta aggttgccat tcttttatttgactatgtgc
251521 aagttgaatg agcttttccc ctcattgtag gaggtccctc agcctgagggtctaagaggg
251581 gaaaagtgca aagtcaccct aagcaggagc tctctgaagc agtctgtgacacactttgtg
251641 tcctaaacct gcctcactta cttgttcctc cagagaaaac tgccatatttcatttttaag
251701 ctcttttagg acttaaaacc ttataggaaa tcctatatct aagatatttatcaacctgct
251761 aaagtgtaat cagagacctc aaatataaga gactgtccat cagataaactactatcacat
251821 tccaaaaatc gaagatattt tctagtcttt tgactatatt gctctggttgggctgaagtc
251881 agaggtatca tttacattac tgaggcctca tgagtatcat ttctgtgttgctcctttagt
251941 ttctgtggtc agtggagaag aatagtttct catgtctgat gactcagcttttattccggt
252001 aactgtgcag gctgtgtacc ccacagccat tctgcctagg ttcaaatcccagctctacca
252061 tgtatgtatt tatacaatca ttaacagatg gctcaactgc tttgttctcctgtttcccct
252121 tggtaataga ggtgtaatgg atgtgaggac taaatgaatt aatacaaacaaagcacttag
252181 aatatgcctg gatgagaaaa ttattcaaca aatgttaaca attttattaggctatatttt
252241 attaggctat attatatttt attagcctat aattcatagg cttatttaagaaaaaaagcc
252301 agcatggtag gagttgaggc cacattatag atccccaaaa caaggcagtcatgtatggtt
252361 atgcagttgt acatcagtag atttgtatat ttaataaatg attttctggcagatgaattt
252421 aaagtatcta gagcagcatt gtgccaggca agccacatat ataagtttaaaacttctagt
252481 agtcattaaa taaatagaca ggtacattta attttaataa taaatatatttgctttaact
252541 caatatatca aaagtattat cattttaacg aacaatcaat ataaaattattattgagata
252601 ttctctgcct ttcgaaaggt atcaagtctt tgaaatctgg tgtgtattttataccagtcg
252661 catttcaatt gttcagtagc cagatgttgc tggtggaaca ctctgttgggtagagtggct
252721 ctagaggaag tagtggcttt ttcaaagttg ctcgaagatg ccatttgggatagctgcagg
252781 gcatcaaatc cacattttcc ccctcaaagt cattcatgtt atatcatccaaaccagtgtg
252841 gccttgaacc ttccctctgg catggacctt tggctgctcc ttacctggttaacaagtagt
252901 tcaaactcat tgcccaaaca gcaagacaac tcaaaaacaa tacaccactctcactccacc
252961 accagcccat gggagaatat tcagtagaaa aagaattgat gagatataaatctttgtaca
253021 gaatcattaa tcatctcttc ctactcctat cccagtcaaa tattctcttggaataagttt
253081 gagcggattt atgacataca ttactcaaat ggaatagaag gtaacctaagttctaaaatc
253141 gactaggcta catcaagatt ttttcactgt actcattctg ttagcgtctgcatactcatc
253201 cacaaaatgg gagcaaatat ctatttttag ttacttaata gcaaaatcagaaaataaaaa
253261 gatagaaatc caagaaaata gtttgaaatt ttaagataag atgactaactttgttggccc
253321 aggattctcc tggttttaga actgaaagtc ttgcatttga gaacctttcagtccccaaca
253381 aacatggatg gttggtcacc ttggttttaa gtccttccct tttcttcttcctcccttcat
253441 tcatttcttt tatccttttt ttttttcctt ttctttccag gtcagtgtacattttcaacc
253501 acatcatatg cttagaaatc ttcatgataa atatagttac ataagtattaaaagcaaatt
253561 aaaacagtat aacataaagt tacacaacat ggaaaccatc agctcatttaaatattgtcc
253621 tcattagttt gaagttttat atcataaaat aaaggtggct tgacatcagaacccaactgt
253681 tcccgttaaa aacaattctc taagctaaaa atttggggtt ttactggtctattttacagc
253741 agctaaacta ctggaagcag ttgaatcatt ttgagaatgc atgtcttaataagaaactca
253801 tagctatttt atccttgtag gctttttcaa gactttttcc tgtttgtaggatgttttagt
253861 ccatttcgtg ttgctataaa ggaatacctg aggcttggta atttgtaaagaaaagaggtt
253921 tatttggctc acagtctaca gactgtacaa gaagcatgga gtcagcttctgcatcaagtg
253981 agtgattcag ctgtttccac tcctggtgga aggcaaaggg gaaccagcatgtgcagagat
254041 cacgatggtg agataggaag caaaagagag atggggaggt gctgggctcttttaaacagc
254101 cagctctcgt gggagctaat agaataagaa ctcacttact atcccctgcaaaagaaggca
254161 ttaatctgtt cataaagaat cttcccctat gacccaaaca cctttcattaggctctacct
254221 ccaacattga gatcaaatct ctacatgaca tttggggaga caaacagcgaaaactcagca
254281 cagggctccc tgggattaga tataattttt ctgtttatga tcctggctataataatactc
254341 atagaatgga ctaacaaata ttcttggata cttaaatcat gtgctatacgtaacccttaa
254401 atggtgtcaa aatttttgtc tacatagact ataatataga ttatatatatatgagatata
254461 tattataaac tacatatatc acaaaccaac ctcaacacat gcagataaatatttttaaat
254521 ttggcaaaat gacagtatgt tcatccatat ttctggagct gcaacaataattataaatta
254581 tacttgaaat aataataatt aacatctgtt gagcatctct catgaatcagtttaaattac
254641 attacttcta atccctaaac attgcaaagt agctattagt tttataattttacagataat
254701 gaaataaaac tcagagatcc taaatgaact gcacaaggtc atttgactataagacctctt
254761 tgaatttaga gttttctagt tcaaaagata tcttctaccc cttacaccttgccacctctc
254821 tgtactgtgc ttctccttac gtaggccaag gtgttcctcc caccaatcttatatactgtg
254881 ttgagtaccc attagttatt cctattggat ggatggagaa attaaggctcagcagagttt
254941 gaggatttca ctaagttcaa atgcccagta atttgcataa ctgaactttgaacaccttgc
255001 tttaatttca gcacttagct tttctaattt ctgatgtgga ttcatctatattgatgataa
255061 caatcatcaa tatagactga tgtctctgtc tcgtcctggg tagcctttttatttttaaaa
255121 attctgtatt aaaatagttt cttgtctgtt gttaaattcc cttagagttttatggccttg
255181 atgtgactca tgtgaccaaa cgttttgtta aaaaaaaaat taaacttatcaaaaccaagt
255241 ccttgttcta caagactctt gcatattcca agataaatca tggccagcttcacacacacc
255301 atttctaaat caacgagact ttattttctt ccttctactt agatgtcagtgcctttgtcc
255361 attttctttt cacttctttg gtacatgttt acccagacag ttatgacctacctgatactc
255421 tgcctaaata tcttccatgt ctcttgacat ccttaatttc ttaacattgaaattgtttct
255481 ttttcctccc cattttccca cccccaatta atttttttct ttgtcgaaggaatttctcct
255541 tatctattta gtagaaagca gtcagagtgc ctcatagacc ccagtctaatattttacttc
255601 tcagagatat tttcattgga gatcataatg tttgatgtat gtaatgatgaatttcagacc
255661 ctagagaaag ttatggaagg gtaagtggac ctggcctaca gggcatgatattctggcaaa
255721 tcccacaaaa catatggtta tctcatcttc ctcaaactat agttgaccttatttcaaaaa
255781 tgcttggagc agaaaagcaa cgaggtatga aagacatgaa gtcaccaccttccattttat
255841 attactactc tatgaattgc atctagattt taaaactcaa cataaaaaactgtcttcttg
255901 caagcatgga ctaataagga tagtagtagt tcacaaagaa tggcagctatttacaaagtg
255961 aggtgatatt gtcaaaacct atcataatga caaagacaga actaaacagtgatagaataa
256021 caagcatatg tggtatgcat ttattatatg tattgtgcca tgcaaaaaagcaatttatgc
256081 tgtatgtatt tacttggtga ggctctttcc agtgctaagt ttacttctagaatgacaatt
256141 catgtattca ttcatttgat tactatttgt ggaacaccta gaatgggtaatctaagagaa
256201 ctatccagta cctgggtatt tcatggtgag caaaataaag tccttgcctctgtggtgctc
256261 agttggggaa atattgtaaa caaagaaatg accagtggtt ttggccaatgtagtataatt
256321 ttatgttgtt gttatcctct gcagtcaaat atttgctaca gcttcttcatcctcaagaat
256381 tttaaatagt tgagaagagc caagatggct aacaagatgc agccaggaagagcttctccc
256441 aatgagaaac cagggtatta agaagattgg cacactccaa gtagatcttcagaagggagg
256501 cattgagagt ggatggagga aggatgtaga ctctgtgctg aagttagaggaagcttggaa
256561 tgctatgctc aggaatgagt tctaggactc attcctggct ccgagtgtctcctaaggaag
256621 ggagagttaa ataggcgtgg agtagcccac tctcaccatg gacctccataattctagctg
256681 caggagtctc aatgaccccc atggatattt gaactgatag ggggagctgcttgaagagtt
256741 gacagggaca ggactgcaga ctgtgtggag ttcagaggat ttggcaaaggaaggactgca
256801 gtagagcaca gccaaggaca cccatccctg aagactcacc atgcccctgtaggctttggc
256861 ctttgttgac tgtcagacca atacagagca gggctgtctt gcccatggaatgaggccatt
256921 ctgatctgag tgcctccctt gtctgccagc ctttcctgag gttcatgccaggctgtgccc
256981 acttgcagca caggcttgga tgtccaactg gggcacttcc taaaggccatcatcatagct
257041 tctttgttgg cagaccccac ccaactgttg gagagcttct gaagacaagcctccacccgc
257101 acacaaccac ctgcagcctc ccccctctgc tttgccaacacgcaggtatgcatggaccct
257161 gctgctctgc tgccaccaac acatgagcac agaccccact gccactgccccgacaaagca
257221 ctgttgccag caaccctcat ggagcattgt tgttaacaga ctggaaacacctcagctcct
257281 tcagcacagc aggtgtttaa ccttgagagg ccagagaaca aagctgtgtgcctggtccta
257341 taccactggg ttacagcaca cagtccagga gtgctgagct gagcccaggtcccctgaaat
257401 cagccagaaa tgaagccagt tgactagacc taacttatat cacagtcaaaacctcaaagg
257461 catcaaagaa ttgcaacttt aaagattaaa gaaacatcag ctcacacagatgagaaaaaa
257521 ccagcaaaag aactggggca actcaaaaag ccggagtgtg ttctcacttccaaatgacca
257581 tgctagctcc ccagcaatgg ttcttaatca gactgagatg gctgaaatgacagacataga
257641 attcagagtc tggatggcaa tgaagattgt tgagatttag taggaagttaaaacccaata
257701 cgatgaacct aagaatccag taaaacaata caagagctga aagacaaaatagtcatttta
257761 agaaccaagc tgatctgata gagctgaaaa ccccattaca ataatttcataatacaattg
257821 gaagtatcag gagcagaaca gcccaagctg aggaaagaat ctcagagctcaaaagtggtt
257881 cttcaaattg actcagtcag acaagaataa aaaagaaaga ataaaaaggaatgaacaaag
257941 cctccaagaa atacagaatt atgtaaaaag accaatccta tgactcactgacatccctga
258001 aagagagggg gagagagaaa gcaagttaga caacatattt gagggtactgcctatgaaaa
258061 tttccccatc ctcactagag aggtcaacat tcagattcag aaaattcagagaacccctgc
258121 aagatcctat aaaagatgac catccccaag acacatagcc cacagattctttaaggtcaa
258181 tgcaaaagaa aaaatattaa aggcagctgg agagaaggga aagacatctataaaaagaac
258241 ccatcacact aatggcagac ctttcagcag aagcagtaca accaagaagagattagggcc
258301 tatattcacc atcctaaaag aaaagaaatt tcaactaaga atttcatatcgagcctaact
258361 aagcttcata agcaaaggag aaataaaatc cttttcagac atgcaaatgctaaaggaatt
258421 cattactatc acacttgcct tacaagaggt ccttaaggaa gtgctaacatggaaataaaa
258481 aactgttacc aactaccaca aaaacacaca taagtacata gaccactgacactataaagc
258541 aactacacaa tcaagtccac ataacaacca actaacaaca ctatgacaggatcaaatctt
258601 cacatatgaa tattaacctt aaatgtaaac gggctaaatg ccacattcaaaaggcacaga
258661 atggcaagtt ggatcaagaa gcaagaacca actgtatgtt gtcttcaagggacccatctc
258721 acatgcagtg acacccacag gctcaaaata aagagattga taaaaatccatcaagccata
258781 aagagattga taaaaatcta tcaagccata aagaaattga taaaaatctatcaagcaaac
258841 agaaaacaaa aagagaagag cctgttattt ttattttaaa ccaaacagactttaacctaa
258901 caataatcaa aaagggacaa agaagaggat tacataaaga taaaagattcaattcagcaa
258961 gaagacttaa ctgtcctaaa tgtatatgta cccaacactg gaacacccaggttcataaaa
259021 taagttcttg acccacaaaa agacttagat aactacacaa taatagcaagagagttctgc
259081 accttactga cagtattaga cagattattg aggcagaaaa ctaacaaaggtatttgggac
259141 ctgaactcaa cacatgacca aatggaccta acagacatct acagaacactccacccaaca
259201 acaacagaat atacattctt cttatctgca aatgacacaa actataaaatcaaccacatg
259261 ctcactcata aagcaattct cagcaaatta agaaaaactg aagtcacaccaacaacattc
259321 ttggatcaca gtgcaataaa aatagaaatc aataccaaga ggatctctaaaaatcacatg
259381 attacatgga aattaaatag cctgctcctg aatgactttt gggtaaacaatgaaattaag
259441 gcaaaaatta agaaattatt tgaaactagt gagaacaaag acatgacataccagaatctt
259501 tgggacccag ttaaagcagt ttaaaaggga agttatagca ctaaacacccacatcaaaaa
259561 gttagaaaga tctcaaatta acaacttaac atcacatgta gagaaaccagagaaacaaga
259621 gcacaccaac cccaaagcta gcagaagata agaaataacc aaaatcagacctgaactgaa
259681 tgaaattgag acacaaaaag ccatacaaaa ggtacataaa tccaagagttgtctatttga
259741 aagtataaat aagattgata gaccactagc tagattaata aagaaaaaagaagattcaaa
259801 taaacacaat cagaaatgac aaaagggaca ttaccaacaa ctcaaaagaaacacaaaaaa
259861 ccctcagaga ttattacaaa cacctctatg cacacaaact agaacacttagaagaaatgg
259921 ataaattcct gaaaacatat aacctcccaa gattgaacca ggaagaaattgaaaccctga
259981 acagaccaat aacaaattct agaattgaat cagtaataaa aagcctatcaaccagaaaaa
260041 gtcctggacc agacaaattc acagccaaat tctaccagat gtataaagaagagttggtgc
260101 caatcctact gaaactattt caaaaacttg aggaggaggg atgcctctttaactcattcc
260161 atgagaccag catcattctg ataccaaatc ctggcagaga cacaatgagaaaataaaact
260221 tcaggccaat atccttgata aacatacatg caaaaatcct caacaaaataatagcaaacc
260281 aaatccacca gcactcccaa aagtaattta ccatgatcaa gtaggctttattcctgggat
260341 gcaaggttgg ttcaacatac acaaataaat aaatgtgatt tatcacataaacagaatgaa
260401 aaacagaaac tacgtgatca tctcaataga cgcagaaaag gctttggataaaattcaaca
260461 tcctttcatg ttaaaaactc tgaacaaact aggcattgaa ggaacatacctcaaaataat
260521 gagccatcta tgttaaactc acagccaaca tcatactgaa caggcaaaagctggaagcat
260581 tatccttgag aactggaaca agacaaggat acccaccctc actattcttattcaacatag
260641 tacgggaagt cctagccaga gcaattaggc aagagaaaga aataaaaggcacgcaaatag
260701 gaagagagga agtcaaacta tctctctttg tggacaatat aattctaaacctagaaaacc
260761 acatagtctc tgcccaaagg ttcctagatc tgataaataa cttctgcaaagtttcagaat
260821 aaaaaaccaa tgtacatttc tatacagcaa tattgtccaa gccaaaccaggaatgcaatt
260881 tcattcataa tagccacaaa aagaatataa tatctaggaa tatagctaaccagggaggtg
260941 aaagatctct acaatgagaa ttacagaaca tagcttaaag aaatcagaaatgacacaaac
261001 aaatggaaaa attccatgct catagatggg aagaattaat attgttaaaatggccatatt
261061 acccaaaaca ctttacagat tcaatgctat tcctatcaaa atacaaataacagtttttag
261121 agttagaaga aactatttaa cattcatatg gaacccaaac accctgaatatccaaagcta
261181 tcacaagcta aaaattaaaa aaaatttaaa aagctggagg catcagaatcacactacctg
261241 acttcagact atgctacaag gctacagtaa ctaaaatctc atgatactgatagaaaaaca
261301 ggcacataga ccgtattagt cagggctctc tagagagaca gaactaataggagatatata
261361 tatatatatg ggagcttatt agggagaaag gctcacatga tcacaaggtgaagtttcgtg
261421 ttaggccgtc tgcaagctga ggaaggaaga agccaagagt ggctcagtctgagtccaaaa
261481 gcctctaaaa cagggaaacc gacagtgtag ccttcaatct gtggctgaaggcctgagagc
261541 ccctggcaaa ccactggtgt aagtcccaga gtccagatgc tgaagaacctggagtctgat
261601 atccaagagc aggaggatga aaggaagcat ctagtacagc aaaaagatgaaagccagaag
261661 actcagcaag ccagcttacc ccactttctt ccacctcctt tgttttagccactgtggcag
261721 ctgattagat gatgcccacc cacattaagg gtgggtcttc ccctcccagtccactgactc
261781 aactgtcagt ctcctctggc aacaccttca cagacacacc aagaaacaatattttaccag
261841 ctatctaggc atccttcaat ccaatcaagt tgacacctaa tattaaccaccacatagacc
261901 aatggaataa gttagagaat ctagaaataa agctgcacat gtacaagaacctgatttttg
261961 acaaagttaa caaaaacaag caatggggaa aggactccct gggtcatacacagcattgga
262021 ataactggat agccctatcc agaagatcaa agctggactc tttcctttcaccagatacaa
262081 aaatcaactc aaggtgggtt aaagacttaa atgtaaaatc gaaaactataaatttttagt
262141 ttttaaaact aatctataaa aactcttgaa gaaatcctag gaaatactattctggatatc
262201 ggccctggca aatccttcat taagaagact ccaaaagcaa ttgcaataaaaaccaaaatt
262261 gataggtggg acctaattaa actaaagaac ttctgcacag caaaagaatttatcaacaga
262321 ctaaacagac aaccaacaga atgagaaaaa tatttgcaaa ctatgcatccaagaaaagtc
262381 taatatccag aatctataag gaacttaaac taaccagcaa aaacaaaacaaaacaaaacc
262441 ctaaaaaacc attaaaatgg gcaaaagaca tgaacagaca cttctcaaaagaaggcacac
262501 acggccatta agcatataaa gaattactca acattactaa tcattagagaaatgcaaagt
262561 aaagccacaa tgagatacta tctcacacca gtcaaaatga ctattgttaaaaacaaacaa
262621 acaaacaaac aaacaaaaaa cagatgctgg catgactgtg gagaaaagggaacacttaga
262681 tgctgttggt gggaatgtaa attagttcag ccactgtggc aagcaatttgaaaatttctc
262741 aaagaactca aaacagaact accatttagc caagcaatcc aattactgggtaaatatcaa
262801 aggagtagaa atcattgtac tataaagaca catgtactca tatgttcaccacagcactat
262861 tcaaaacagc aaaaacatgg catcaaccta gatgtccgtc aacagtgtactggatgaaga
262921 aaatgtagta tatatacacc atgcaatgct atgcagccat aaaaaagaattaaattatgt
262981 ctttgcagca acattgatga agctggaggc cattatccta agtgaattaatgcaggaaca
263041 gaaaaccaaa taacctcata ttctcacttg taaatggaag ctaaacattgagtacacatg
263101 gatgcaaaga agagaacaat agacaccagg gcctatgtga gggtggagagtgggagcaag
263161 gtgaggattg aaaaactacc tattggttac tacgctcatc atctgagtaatgaaataatt
263221 gatacaccaa acccccacaa catgcaattt acccatgtaa gcaacctgcacatgcattcc
263281 ctgaacctaa aataaaaatt agaaagaaaa aaataataat taaaaaaattatctggggga
263341 aaaataattt acattagtag caccctcttg tcttcagggg atatgttctaagacccccag
263401 tggatgccta aaactaagga tagcaaattc tattgctgtc agttggaacatgtttctttt
263461 catgtcttca gtccacatat ttaatgactt ttccacttta actaaattttaatcacacac
263521 tgtgaccatc acttttacag tttgaggtac aacagcaaaa ctatcattaatttctttttt
263581 cttcttcaca atttcatgga tagaagattt gttcttactg tagatcttagcaacctcagt
263641 gtatgatttt cttttccttc cttattaggt caaaaacttt tgccttttcacttaaaggaa
263701 gcactttaag tcttatctgt ggcatatctg aattgccagc atcactgctcttgcactttg
263761 agagtattac atgaaataag ggttacttga acccaagcat tgccttactgtaatagtaag
263821 tctgataact gagaggacta ttaacaacat gggtatacta ttgtatccacaggatgcatc
263881 cacactaaac aaagggagaa ttcacatcct gggcagggtg aagtgggaaggtgaggaatt
263941 tcatcacagt actcgaaaca tcataaaact taaaacatga attgtttatttctagaattt
264001 tccatttaat atttttggaa ccatgaattg atcacaagta actaaaaccatggaaaagag
264061 agaactagtc cacatgttgt ttagtatcgc tattacagta attttctttttcttgtgtgg
264121 tcttatcctg tgggcttcta gaaaattgtt tcctacctgc ctctcaatccccttcctctt
264181 ctcaactttc attttagcag aggctacatt atagtgaccc tgttggtttaggatttaaag
264241 aggcatttat ttgatttgtt aaaaacctcc acatgcaccc atgaaataaccaaatgacct
264301 cagggtataa atggagctgc aaacttgtcc aagtcaagaa attcagtataaaaaccttag
264361 gcaggccagg cgcggtggct cacgcctgta atcctagcac tttgggaggccgaggtgggt
264421 ggatcacgag gcagaatatc gagacaatcc tggctaacat ggtgaaacctcgtctctact
264481 aaaaatacaa aaaattagcc aggcatggtg gcgggcgcct gtagtcccagctactcagga
264541 ggctgaggca ggagaatggc gtgatcccgg gaggcggagc ttgcattgagccgagatcgc
264601 gccactgcac tctagcctgg gcgacagaga agactcctcc tcaaacaaaaacaaaacaaa
264661 aacaaaaaca aaacaaacaa aaagaaacac cttaggcaac aacatatatgctagaattgc
264721 ctttgctaac tcccctggca aagcaaatga tgtattgaga ttgcttctcagataaggtgg
264781 ttgaaaatga tagcaatctt aaaaaatgag cagttttcat aaatttgtatacattttgct
264841 ctatagacaa agagtagagc ttatagctat catggccata tctcaataaaaatgtgttgc
264901 aagcaggttt gccttgggca tctttcctta ttcctttcag tattccacttcttttcacac
264961 cctttcccac atgttagatg ttcccagtct gctcattcag ttcgggctcccttccctggg
265021 aggctgtctt cagctcaaaa ctttgccagt gataaaactc cattcaaaacttatctgcca
265081 agtggccatt tttacttgaa gccctgccct tggtcaatga cagtgcaaaaactggatagt
265141 ggcatattaa tcaaataagt cattttctcc ctaggttaaa ccatagggaatatctgcttt
265201 caaccctttt ggcctccaaa aaaaaaaaaa aaagcatttt gtatggcttttcatacctca
265261 tggtgtccta gcttgagcac tggagcaaag tcagaaaatc tgagcccttgacttatctct
265321 gtggttcact gctggataat gtccagaaaa ttatttcatg cctttgagcttcagcttcct
265381 tatctgtaaa aaggagagta actaccttga cttcttgctg agattttaaagagaacaaat
265441 gtgaaagcac acacaatcac catttgcaaa gggtaaagtg gtagatggatgaaaggaata
265501 atgatctgta atttttcctt acatgctagc ctatttaaaa tgtatgagcctccatgataa
265561 gtgtggctaa tagtggggga atgtagatga tctagagata ccggtcaacctacaatgtca
265621 gctttatgtc attgtgcccc tttcttcttt ggggtttata tgactataatattttaaaaa
265681 ccaaaacctt atgggaccat tttataattt gtgtcatatg aaattttaattttgctattt
265741 atagtgaaag ggaaaaaagg aagtggagta tataggatat agatctctaaccactaaaat
265801 aaacctgtga gtaaatgcat tttaagctct tcatgcaaat acatatatatatatatatac
265861 acacatatat atacacacac acacatataa ttactgatta aaaatatatataaaatcaca
265921 tatatataca tataaaacca cttggcattc aggttgtata aaaatgttgatttttattca
265981 agaattgtag agtagatgga aatttaatgt actcaatgta atctctatttgggatgagat
266041 tctaggggga attaaaattt acataggagt ttctttgcct ggtttagtccatccagaggc
266101 ttcagatggt ctgggaacca actaaagttg tgtggagcaa tgtaaaagtcagtatatatg
266161 tttcttttcc cctggggagg gattcaatag atttcatcgt attcttaaagaaattcttgt
266221 cctaccaaag gttaagaact aattatctca gttaaacaaa acacataaaaatatgttttt
266281 atatacatgt tgaattattc aaatcttcag tgcttagtag tttattaatcttgaaggcct
266341 agaaagtgaa taatttcaac aactgaacaa aaataaaatt taaaaagaaactattttctg
266401 gtcattagaa caaacttgtt ataaaatata tgtctttttg ctattgcttctccacttcaa
266461 cactcatgat catgttttgt tgctatttcc cctatctcat tttttctggctgctgggtta
266521 aacttcctgt ttttgcagaa tgaccaaaaa cattggtgat gatggaggtggagatgacaa
266581 cactttcaat ttcagctgga aggtctttac cagctgggac tacctgatcggcaatcctga
266641 aacagcagac aacaaattta attctatcac aatgaacttt aaggtagaggcaccaacttc
266701 aaaaacctgc tgtttgtatt tctaagagta aaattggagg cattccatctggtccagtag
266761 tgcagtatct tgacaattta catgaaagat taactcatgg tttctgcctaccaagatctt
266821 gccatggttc tgattataac tggaaaatct tccatgaccc acaacagcactattattcct
266881 taaacacttc tcttctctaa atctggtaat aaaataatgt tactggattgaaataggacc
266941 atgagtaatc agaataagat attttaaaaa ctagaacaat gttcactaattatttacagg
267001 aataagcata atattgaagt gaccctaaaa cattattttg tagttttttttttaattcac
267061 tggaatgaag atttttagag tgaagactat cctaatatca gagcaatcacagtttgtttg
267121 caagaattct tccttctgtc ttacttgcca tcgtttgttg gcaatattcacctggtttgt
267181 ggaatctcag atttagttta cattgtcatt cctcacattc tgatgattgtaaaaataact
267241 tttgaggttt tgatactttt aaaatgtagc taagatattc tattttgggtttttgtttgt
267301 ttgtttgttt tcatggatac aggaagctat cacagaagaa aaagcagcccaagtagaaga
267361 aaacgtccac ttgatcagat tcctgaggtt tctggctaac ttcttcgtgtttctaacact
267421 tggagggagt ggatacctca tcttttgggc tgtgaagcga tcccaggaatttgcacagca
267481 agatcctgac acccttgggt ggtgggaaaa aaatgaagtt cgtctctgcatgctttttat
267541 gtgcttagaa cctgacattt gtttcttttg tgggttatgt ttctttgatggaacatttaa
267601 aaaggccacc ctttacctat cccctatcct gcccttacag ttaaccaaccctgttgctca
267661 ttttccattc tattctagtc ttatttctaa atctggactg tctgtttttcattttgtgac
267721 atgatggaaa gttagagtca gaaaagatat taaaaaacac atagtctaatcattatgttt
267781 tacagatggg aatgataaat ctcaagagat tgcattatat gtttatggtcacagagttag
267841 gagaagagtc agggtgagaa cctaggaatc ttgacttcga gtccaaggctcttgctgctt
267901 tctctgcaaa tccttcatct gtcattaaaa gatcaaattg ttgcctgaactttttgaagc
267961 agccatgata aagccactga ttcctatgtt gatctcactg gaaacactcagattgcttct
268021 ccacctttgg gcatgtctgg gcttccctct gttttcatta gaagcctaactgcagcatct
268081 ccatctccat ttcctcctgt cctgtacctt actttctctc cctctaaatgctattcaaat
268141 gaagaaggcc agctcttttc caggaattaa acattatgac cgtaatttgcctttagagta
268201 tctgcccatt tagtgaatca gagaaaggag gttagacata gatcatttagaatcagaaaa
268261 tcattggtca tgagttgttg ctagagtctg ttcccgttca taaaatgcttatgtgtatga
268321 tgtgacgtca ttttgagctt gggcattttc aaagtatgtg cagatttaggctgtgggaag
268381 tgtagacttc ccacactgaa acttttgcag aacagtatag atcaaaagaattaaaatatg
268441 tctttataag catagaattt tctaaaaaat cttggacagc aaatgatataatctacttac
268501 agaaaaaggt tccaaataac attctgagta tttcagaagt ggtaccaatagagacgggac
268561 tagatatttt aaagacttta atatacagtc atgtcataaa aacttgtaaaatataagtaa
268621 tttagcagag ggcttttatt tatttaaaat gaaaaatgta ggaacacctcaaagcattta
268681 ctaagtttgc tttcaaaatg gtctcataat tgtaatagta catagaggtaacattatcat
268741 gcagctttgg tccattattt atattggtta tgtttttgta taaataaaccatattaaagg
268801 atgggtagtt gattatcaat aaaataacta ttctttgtaa gaacctctttaacatatatt
268861 ttagggaccc tctgagtcct aggggccaat gaaggtaata atggagattcatgagtaact
268921 ttacaaattt gataaaacca aatttaaatt tgccttgcat aagtttgcacaggataagcc
268981 aaattttctt tacattagtc taaaattata gcatgctgat tttgtattatgtcatgctga
269041 gatttggatc ctgttggtca tacttatata atgttttaat aaaaatgacaaaaatctaat
269101 agcaattgtt ttctaaatat agtctggtag ttattataat tattcacaccacgaagtcca
269161 caggagaaaa taggaaatgt ttagtggtga cagtttgagc cgggtatttgggaaaggaga
269221 tagtcaccag agttacctaa aatcggtatt tccctattag aaaattagtacatgttttgg
269281 attcttttta ttgacttcct ttagccaaat aatatcatca taaggttgccaaacatccag
269341 gaaataaaaa gcacatgttt cctacttttc atgtttctat tccttcttctttctctctcc
269401 cccctctccc cacccctgca ttattctctt gtctctgaaa ttatagcccattctttcact
269461 tttgaaactt ttctacgttg gcttccataa cattatgtca tgtgttctccatttgtttct
269521 ctgagttcct tctgtttcct ttaataaaac tcattgtatg tgtttatgttttcggcctta
269581 aaagtttaca tttgccaaaa ttcaatattt aggcctaggc ccatctcagggaattcatcc
269641 attctaactg attaaactag cccatatgct gatgattgtc agattagaattttcagtttg
269701 aacctcctcc tcaagcagat tattttccat ttcttttgga aatcttgttgtgaagtgcat
269761 caccatatca gaatcagtta ccacatagaa caatatgtgt tctctgtgtagagactgatg
269821 taaattgcca ccttcactat accaggaaac agactgttac tactggcacatacacacact
269881 cagtcacatg cctctcttga gaatgtgaat tgaatatttt ccctgtcattttattgagat
269941 caaattctaa acgtgcataa aatagtcatt tttagtctta aaaaagatcaaagaagccta
270001 gctcagaatc ttccaaaatt ctggcaaaaa gcaataataa ctttaaacaccattaaccta
270061 gtttctccct tgtgcctcct tgtagatgaa catggttatg tccctcctagggatgttctg
270121 tccaacattg tttgacttat ttgctgaatt agaagactac catcctctcatcgctttgaa
270181 atggctactg ggacgcattt ttgctcttct tttaggcaat ttatacgtatttattcttgc
270241 attaatggat gagattaaca acaaggtaag ccttgtttct ggattgtccttgccataaga
270301 gtgttgttca attcccagtc tcaagtttgc cagaaatgcc tttgaaatctctgttgtctt
270361 cattttagtt tctatctctt tgctttctag attgaagagg agaagctagtaaaggccaat
270421 attacccttt gggaagccaa tatgatcaag gcctacaatg catcattctctgaaaatagc
270481 actggaccac ccttttttgt tcaccctgca gatgtacctc gaggaccttgctgggaaaca
270541 atggtgggac aggtaatgcc accaacagaa gtgtatggca attagtagattaaaaaaaga
270601 gagtcaatat ctcttccata agattggctt ttaaaaaatt gcttattagtaaaaatagct
270661 aagatttgtt gaatgttgac tgtgtgctgg ctctgaattt catgtatattatctcacact
270721 gtttgcaaat ctatcccttg aggtaaatac tatttgtatg tcccctttacagttgcatat
270781 aaaggaagga tagttgaaaa tggtgcaaag agatgtttac tatctgtattataataaagc
270841 actcgattta gatacaggcc aaagcaaata tttaaatgga actctatttagtgttacttg
270901 tttgctgtaa aacaaaacaa aacaaaacaa acaaacaaac aaaaacagagtcttgggggt
270961 ggccaagaca gccaactaga ggcagctagt gtgcatggct ctcatggagagaaatagagg
271021 ggttgagtaa atatagcacc ttcaaccgaa acatccaggt acatgcattggatctaatca
271081 aggaaacaac ttgacccatg gagagcagag aaaagcaagg cagggtgacagcccacctgg
271141 tagtgacatg aagccaaggg atccttctat gcccagggaa gtggtgagtgaatgcacgac
271201 cttgggaacc catacttctc ccgtggatct ttggaaccct tgtgtcaggagatatcctca
271261 tgaacccact ccacctgggc cttcagtccg acacacagag ctatgtggagtctcagcaga
271321 gcagccactt aagcacatgc agagacccgg gagccttaga tacctgggcttttctttttg
271381 ggcttcctgt caaaagtagc tatacctctg gcaaagcagg aggttagacccccaaccaca
271441 ccccttagaa aaggggctga atccagtgac agtctgcagg ccccacttcacagcacctca
271501 cagaatgaaa cccactggct tggaactcca gccagttacc ggtagaaatgttgcacctcc
271561 ctgagacaga gctcctgggg gaaagtgtgg gccatcatct ttgctgtttggttgacttgg
271621 ccattccatc attcaggctt cagagagtcc aagccaacca gcggctgaagcagaccctga
271681 gcacagcata gctgttctat gaaaatgtgg ctagactact ttttcaaatgggtctcctat
271741 ccctttcctc ctcactgggt aggacctcct aactggggtc tccaaccacctcctacaggt
271801 gcgtttgggc cagcaacggg tctgtacatt tctgggatgg agcttccagaggtgggggca
271861 ggctgccatc tttgctgttt cacagccttc actgttgcta cctccagataataaaacatc
271921 tgaggtgacc agggacggat gtggggtccc aatatactgc agcagccctatgaaaaagtg
271981 accagacttt tacatgggtg cccatcccca tatcggctca ccagacacatcctccaggcc
272041 taggcctcca gctaccctct gctagaatta tcgatcaagt agcagctctgtaactccctg
272101 gacaggatcc ccaggggcaa ctgaaagttc ctctgccact acctctgcagtagaactgcc
272161 cttgctaccc ttggactaac aaaggaacaa agaccctaag cgcctcatccatacctccaa
272221 taagctgcag ttgactccag gagagaaggc cagtctgtct ctcacaggtcctacctaccc
272281 ccacccccct ccttgtcacc agacagggaa cccccagctc ggacccacaacatagaacat
272341 ccatcctggg ctaattgcaa ggagtaattg ctgacctgca tctcaatggggtggagcccc
272401 caggagataa gcaaaagacc cttggccata accatgccaa ggtatcttcctctgctgctg
272461 ccaagttgga gaagaaacat aacgctgaga ttgccccaga gctgaaggggcagcccagga
272521 gtgccaagcc gtaatctaca gccagctctc aagggggaaa gaaatctacactttcagagc
272581 attgagaggg aacatggctg caactgtgcg gcaacacagg ggagcctcacaaccaagcaa
272641 gagtctacca actgaccaat atgccgaagt gccacctact ggatcacattccccaaagca
272701 tcaacaccaa aaatatctca ctaacatacc cccctctgaa accaaagacaagtactcagc
272761 ttcaaataaa gaccctgtgc aaagccttgg cccaatgaaa acttccaggaaagatgccta
272821 ttgactgtat tcaatctaca ttgcagttaa aggaacacct acacactgagatgagaaaga
272881 accaatgcaa gaactctggt aactcaaatg accagagtat tgtatgtcctccaaacaacc
272941 acaccagttc tccaacaaga gttcttaacg aggctgagct agctgaaatgactgaaatag
273001 aattcagact gtggagagga atgaagatca ttgagattca gaagaatggcaaaacccaat
273061 ccaaggaaaa taagaatcac aataacacga cactggagct gaaggacaaagtagctgtta
273121 taaaaaagaa gctaataggt ctcataaggc tgaataacac aatacaggaatttcacaatg
273181 caatcacaag cattaacagt agaataaacc aagctgagga aagaatcttagaacttgaag
273241 actggctctc tgaaataaga cagtcagata aaaataaagg aaaaagaataaaacgggaag
273301 aacaaaacct ccaagaagta tgggattatg taaatgccaa agctatgaatcactggcatc
273361 cctgaaaggg atggggaaaa agcaaacaac ttggaaaaca tattttaggatattatccat
273421 gaaaacttcc ccaaccttac tagagaggca aatttgctgc cagtctttgctaacagtcaa
273481 atttaggaaa tacagagaat tcctgcaaga ttctacacag gaagatcatccccaaaacac
273541 acaattgtca ggttttctca ggtcaaaatg aaaaaatgtt aaagacagccagagagaaag
273601 ggcaggtcac ctacagagag aacaccatta ggctaacagc agatgtctcagctgaaaccc
273661 tacaagccag aagcagtcag ggtcctatat tcaacattct taaagaaaaaaaatcttcaa
273721 ccaagaattt catatcaggc caaactaagc ttcctaagca aaggagaaataagataattt
273781 ttgggcaagc aaatgttgag ggagtttgtt accaccagac ctgctttacaagacatcttg
273841 aaaggagcac taaatggagt aaggaaagac tatttgcagc taatacaaaagcatacttaa
273901 atacacagac cagtgacact gtaaagcaac catacaaaca agccagcataataatcagtg
273961 aacaacacaa tgacaggatt aaatccatac atattaatac taatcttgaatgtaaatggg
274021 ctaaatgctc catttaaaag gcacagagta gcaagctgta ttaaaaaaaaagcaagaccc
274081 aatggtatgc tgtcttcaag agacccatct catgcttaat aacacccacacgctaaaaat
274141 aaagggatgg aagaaaatct accaaccaag agaaaacaga aaaaaacatgggttattgaa
274201 attaaaattc ccaatttcaa aaaaaaaatg caaaaaacaa aacacacacatgcacacaca
274261 aatacacttc aaaccaacaa agataaaaaa aaggcaaaga agggcattacataatggtaa
274321 agggttcaat gcaacaagaa gacctaacta tcctaaatat atatgcactcaatacaagag
274381 tacccagatt cataaagcaa gttcttagag acctacaaag agacataggctaccaccacc
274441 caataatagc ccaggccctg atgaattcac agctgaattc taccagatgtacaaagaaga
274501 actggtaaca ttcctactga agctatttca cgaaattgag gaggaggaggaacttcttcc
274561 cagctcatcc tatgaggcca gtatcattct gctaccaaaa cctggcagagacacaacaaa
274621 aaaagaaatc ttcaggccaa tatcatgagg cccatcaatt caaaaatcttcaacaaaata
274681 cttgcaaacc gaattcagca gcacatcaaa tggctaatcc accacaatcaagtaggcgtc
274741 atccttggga tggaaggtta gttcaacata tgcaaaacaa taaatgtgattcatcatgta
274801 aaaagaaata aagagaaaaa ccacatgatt atctccatag atgcagaaaaagctttcaat
274861 aaaattcaac acccgttcat gttaaaaact ctcaataaac taggtattgaaggaacatac
274921 ctcaaaataa taagagcctt ctatgacaaa cccacagcca aaatcataatgaacggacaa
274981 aagctgaaag cattcccctt gaaaaccagc acgagacaag gatgccctctctcaccactc
275041 ctattcaaca tagtatttga agttctggcc agggcaatca ggcaagagaaagaaatgaag
275101 ggtatcaaaa taggaaaaga gggagtcaaa ttatctttgt ttgcagatgacatgatccta
275161 tatctagaaa accccattac cccggcccaa aagcttctta agcggataagcaacttcagc
275221 agtctcagga tatatcaatg tgcaaaattg ctcgcattct tatacaccaacaacaggcaa
275281 gcagagagcc aaatcatgaa tgaactcaca tctacaattg ctacaaagataataaaatac
275341 ttaagaatgc agctaacaag ggaagtgaag gacctcttca tggagaactacaaactactg
275401 ctcaaggaaa tcagagagga cacacacaaa tgggaaaaca ttcaatgctcatacatggga
275461 agaatcaatt ttgttaaaat ggccatactg cccaaagtaa tttatagattcaatgctatt
275521 cccattaaac cacaactgaa attcttcaca gaattagaaa aaaactattttaaaattcct
275581 atggaaccaa aaaagagctc gtatagccaa gacaatccaa agaaaaaagaataaagctgg
275641 aggaatcaca ctacctgact tcaaactata ctacagggcc acagtactcaaaacagcatg
275701 gtactggtgc aagaacagac acatagacca atggaacaga atagataacttagaaataaa
275761 accacacaac tacaaccatc tgatctttga caaacctgac aaaaacaagcaatggggaaa
275821 atatttccta tttaataaat gttactggga gaactggtag ccatatgcagaaaattgaaa
275881 ctggacctct tctttacacc atgtataaaa attaactcaa gatggattaaaggcttaaat
275941 gtaaaaccca aaactatgaa aactctagga gaaaatctag gcaatatcattcaggacata
276001 ggcacaagca aagatttcat gacaaaaatg ccagaagcga ttgcagtgaaagcaaaaatt
276061 aacaaatggg atctaactaa actaaagagc tccagcacag caaaagaaactatcatcaga
276121 gtgaacagac aacctacaga atgggagaac atttttgcaa tctatccatctgacaaaggt
276181 ctaatatgca gagtctacaa ggaaattaaa caaatttaca agaaaaaaactggatcccat
276241 taaaaagtgg gcaaaggaca tgaacagaca cttctcaaaa gaagacatacatgcggcaaa
276301 caagcatgtg aaataaaact tcatatcact gatcattaga gaaatgcaaatcaaaaccac
276361 aatgggatac cagctctcac cagtcagagt gattagtagt aaaaagtgaaaaaataatat
276421 gctggcaagg tcgcagagaa aaaggaacat ttatacactg ttagtgggaatgtaaaatag
276481 ttcaaccatt gtggaaagca gtatggcgat tcctcaaaga gctaaaagcagaactatcat
276541 tcaacccagt catcccatta ctgggtatat acccagaggt atataaatcataaagacaca
276601 ggcatgtgaa tgttcattgc agcactattc acaatagcaa atacacggaatcaacctaaa
276661 tgtccatcaa tgacagattg gatagggaaa atgtgatata ccatggaatattatgcagcc
276721 ataaaaaaga atgagatcat gtctgttgca gaaaaatgga tctattatccttagcaaact
276781 catgtaggaa caccaaatac tgcatgttct tacttatatg ggagctaaattatgataact
276841 catgaacgca aagaaggaaa caacagacac tggggtctac ttgagggtggagggtgagag
276901 gagggagaag agcagaaaag ataactattg ggtactgggt ttaatacctgggtgataaaa
276961 taatctgtac aacaaactcc catgacacaa atttacctat gtaacaaagcttcacatgta
277021 ctactaaacc taaaataaaa gttttttttt aatggataat ttggggagcacacactaaga
277081 aattttaata atgtcaattt ttgttaaata attttccctt aaaagaaaaaaaatactatt
277141 ttaagttatt tgttttcatg atgattttgt aaataacccc agcccaagactagccatacc
277201 ttaccagaga aaagaaataa tgtttcatat ggctttctat cccttaagggaaaccaagac
277261 aaataaaacc aaacaaaacc caagaaaaat ctacttcaga tctcgtatttttatacaaat
277321 ccaatttata ttttgaaaag cttttatgat ttcatttagt tagaattgatattcctaacg
277381 tgcagtccat aaattgattt tggggcttca gattatcatt gagaacagcttttgtcataa
277441 agcttctgta tgttagacaa cagttgagtt tagcactgaa tgtagtgtttgtgaaattat
277501 ttgaacaatt ttttactgca ttatttggta agataacata aaaattgaaggactagcatt
277561 agtcttataa aattcatata atttaaacaa atatgtaaaa atatatcttaggcttcaatc
277621 agatgctcat caaacttaag ccaatcaaga tttcaactgt gaaagaaaaaaataagataa
277681 atgtgtaaaa tgctagacat gtatcattaa tgattgagta caaaaattatggtataattg
277741 aaaattctat tttattttat ttgttaagct ttcgggaacc agataaatcccccctttgat
277801 gatatatgct attaatttga ttttcagaca tgcacatttc atacaacttacaggaacata
277861 ttacatatga aataataaaa tcaaagtcat ctgcacttaa tacaggagtgcttgtgattc
277921 aggatgtggt agacagaata atggccctct ataacagtac acattctaatctctggaacg
277981 ataaatatgt tacatggcaa aatggacttt gcagatgaaa ttaagttaaagatctcagct
278041 tgaaagaatt attgtggatt atgtgagcag gcttaatgaa atcataaggatctttataag
278101 caggagataa agggaaaaag tcagaaaatt gagatgtaac agcagaagcagaggttggaa
278161 tgatgtgctt taaagatgga ggaaggagat taagagccaa ggaatgcaggtggcctcaga
278221 aactgaaaaa gaaaggaaac atattctctt cccaagtctg cactttgaatttagacttct
278281 gacttccaga actgtaagaa gataaatttg cattgtttta aaccactacatttatggcaa
278341 tttgttacag caacaatagg aaatgagtac atcatggtac ttgggtctccctgttccatg
278401 gctttttgaa gtgaagtctg gttgtggtgc ttaacacgag tctgttttatcacaactaag
278461 ccgctcccta aatcttcagc atacgattca agaaaggaaa atataggaagtacagtttta
278521 gaaactgaag gaatttgaga cgttctcttc tgcacatcct agaacacaggttggcctgaa
278581 agctaagaaa cctgcacttt aacaagcaaa aacatctact gaatgggattaatagaatta
278641 gctgtaaaga gtaggatctg ggctggccac ttctggagtg aaggaatggattaattagat
278701 aggaatgcga atgcaatcta ggagaatatt catgtttcag atgcagatggttctgcgata
278761 gtcccacaca tactgactta aaagagaaga aataccattt agttaatcctccaccttgga
278821 agcccgtgga ttatgctgct tgtctttttt tttttttaaa cctgtctgtagtgattttcc
278881 ttgcttcatc atattttctt actgccattt tagttggatt tcccccttatctttcacctt
278941 cctttctcca aggaagcatt aagctctagt gggaaagtct gcagaagcgggccaagggaa
279001 aaggggttgt ggttctgact ggaatgttga ttaggcagat ggaatctctgggaacaaaaa
279061 gaacatatag gacataacaa atctgagtgc tggcaaggtc tggcctttaagagatcaata
279121 tctgtatcca tgcatctaaa atttctattc tttaattgct taaaaaatatgcctccaaaa
279181 atagtaaagg cagctgctct gtatgtaatg ttagatatgc accctcattcattgttctat
279241 gagagcatta cagatgtttc ctcttctcct ccatggatac cctctgctttgattttctcc
279301 aaggatgcta tgagactcaa agcacttatt gttttgaata taggataatgtgattgctcc
279361 tttacttctg cagattccca agcaatcatt tagtttcatc cccaatggatttgataggtg
279421 ggcagcagag ccattcctct ttgaagctat atcctgaggt cttcactttggggaagggga
279481 gaaagcaaca gctgaagata aaatggctaa tgtgccaagt atttcctcctcaaattttta
279541 cgtttcattc tgagatacgt tatattatta tttccgtttt atagatgagaagactgagac
279601 ttaggtaatt tgctcaagat ctctgagaaa gtcaatgaca ggagccccagttcagcctac
279661 atagtctgct tacagagttt gtgtctttgt tcacagtgct aaattgtcccccagttagca
279721 tcaacacaca ctccccaaac tcctgcctgc aatgtctata tttggtggccttttatgatg
279781 ttccttgcct attgttttcc cttcacctat taataaatta tttctttagctttattgatc
279841 aaagctgccc aggcatttta actaacatca cgtgtgcaaa gtttttaggtgtggagtgtg
279901 gggtttagca ggaggcctgt gtgggggctg tgctccccat cctgacaagcacacaaggaa
279961 ctaggatgat atccttgaga ttggctgggc taccattgtt tggattctctttcttttaaa
280021 atatattttt cctatggtat atgaataaac atttaaaatt tttaatacaatgtttgaatc
280081 ttcttcagat attttatgtg aaagttaggt cactgcttgg gaaggaatagaatttcaacc
280141 tttgggatga ggatgcttaa gaggatgtgg aggacttcca aaccactctgaaatgttttc
280201 ttacctgagg aagtcttcta gacctggcag tagaaaccta aaaatatccctcatagcctt
280261 cctctaattg atgctagtta ttagaatctg agctcaacat tgcctggaaagggtgggcat
280321 ggaggcatgt gtctgtagtc ccagctactc aggtggctga gacaggaggattgcttgagt
280381 ccaggagttc caggtcagcc tgggcaacat agcaagaccc ctgtctctacatacatacat
280441 acatacatac atatatacat acatacatac atacatacat acatacaaagaactgcctta
280501 ggaaaggaaa ggagacaaag agtaggaagg agaaaaatta tgtccaaaaataaccacagg
280561 aatactatca ttcattcatt ttttatttat gagtgtacag aaattgctgggcattgtgtg
280621 attatataat tggaagtaaa acacttctca gcaaatgcaa aataactgaaatcataacaa
280681 acagtatctc agacaacaga acaattagat tagaaatcaa aattaagaaactcactcaaa
280741 accacacaac tacatggaaa ttgaacaatt tgctcctgaa cgactcctgagtaaataatg
280801 gaatgaaggc agaaatcaag atgttccttg aaactaatga gaataaagagaccatgtacc
280861 agaatctctg ggacatactt gaaggaactc ttcaaggaga actacaaaccactgctcagt
280921 gaaatcagag aggacacaaa catatgtgaa aacattccat gctcatggataggaaaaatc
280981 aatattgtga aaacggccat actgcccaaa ataatttata gattcaatgctatttccatt
281041 aaaccaccat tgacattctt cacagaatta gaaaaaaaac atttttaaattcatatggaa
281101 ccaaaaaaga gtccttataa ctgagaaaat ccaaagcaaa tagaacaaaacaggaggtgt
281161 cacactacct gacttcaaac catactacaa ggctatagta atcaaaacagcatagtactg
281221 gtgcaaaaac aggcagacag accagtggaa cagaataggg aacacagaaataagatcaca
281281 gacctacagt catctgatct ttgacaaact tgacaaaaac aagcaatggggaaaggattc
281341 gctatttaat aaatgatgct aagaaaactg gctagcctat gcagaaaattgaaatgggac
281401 cccgtctata caccttatac aaaaattaac ttaggatgga ttaaatgcttatatataaaa
281461 gccaaaacta taaaaaccat agaagaaaat ctaggcaata ccatttaggacataggcatg
281521 ggcaaagatt tcaagacgaa aacatcaaaa gcaattgcaa caaaaacaaaaattgacaaa
281581 tgggaactaa ttaaactaaa gagcttctgt acagcaaaag aaactctcatcagagtgaac
281641 agacaaccta cagaatggga gaaaattttt gcaatctatc catttgacaaagatctaata
281701 tccagaatct acaaagaact taaacaaatt tacgagaaaa aaacatacaaccccattaaa
281761 aagtgggtga aggacatgaa cagacacttc tcaaagaaga gattcacgtggccaacaacc
281821 atatgaaaaa acactcaaca tcactgatga ttagagaaat gcaaatcaaaaccacaatga
281881 gataccatct cacaccagtc agaatggtga ttattaaaaa gtcaggaaacaacagatgct
281941 ggtgaggctg cagagagata ggaaggcttt tacacagtta gtgggaatgtaaattaattc
282001 aaacattgtg gaagacagtg tggcaattcc ttaaagacct agaaccagaaataccatttg
282061 acccagcaat cccattactg ggtacatacc caaaggaaaa taaatcattctgttacaaag
282121 atacatgccc acgtatattc attgcagcac tattcacaat agcagagacatggaatcaat
282181 ccaaatgcct atcaatgata gactggataa agaaaatgtg ctatatgtacaccatagaat
282241 actacgcagc aataaaaagg aatgagatca tgtcctttgc agagacatggatggagctga
282301 aagccattat cctcagcaca ctaacacagg aacagaaaac caaacaccatatgttctcac
282361 tcataagtga gagctgaaca gtgagaaaac atggacacag ggaggggaacaacacacact
282421 ggagcctggt cgggggtaag ggagaaatga gaacatcagg aaaaatagctaatgattgca
282481 ggacttaata attaggtgat ggattgatag gtgcagcaaa ccaccatggcatgtgtttac
282541 ctatgtaata aaactgcacg tgtaccccag aacttaaaat aaaaaaagaagacataaaaa
282601 atttaaaaaa atacacaatt caatggtttc taatatattc acatagttatgcatccagca
282661 tcacgatagc attttgtttt aggggcttac aatataccat tgtgcagacatttaatttgt
282721 tttatttaat tagtctccca agcatattca aatttttccg tttttaatctggaagaagca
282781 gtactttcat gattgtatgt atagatttgt gcacatgtgc aaatattgctgtcataggca
282841 tttctaaaag tggattttct tgatcaagct ccaaacactt taaaatgtgatggatcttaa
282901 caaatttctt cccaacgttg tgcccggttt aacttcccca tcagtttatgctcatgctag
282961 ttcaccacac tcaccaatat gaagaagcat ggattttaca tttgtcattcgtgaggcaac
283021 aactcattgt tttcatttgt atttttatta tgtggggttt cggtatttttcaattttaac
283081 ggaccgtttg tatatgttct tctgtgaatt tttaatttgt gacttttgctggtttctttc
283141 tttattggat tgccaatcta tattcatact gatttgtaaa atcttttaatgtgttagcaa
283201 tactcaccct ctatcatata cgttgcaagc actttttcca catttgtctttcaagtctgt
283261 aaatagtgct attcaccaca taaaatttta aactgctgtg tggccaatattttcctgttt
283321 ttggctctcg tatcatgttt atgaaatttc tcagtaagaa gaaaacttttgatttagtaa
283381 acgggaaata attatttttt aagtaataaa gtcagggtga aatattttttatttacttga
283441 tatgactagt tgttttcttc ttttgccatt aattgcagtc ttcaagccaatacttcttta
283501 gaaatatgac agatttaata ccaacactag gaccatttga agacagaactgtgtgtttta
283561 atagagataa tatctcaaca ggagtttgtg aggctgacag tctctgatgttctgaccacc
283621 tacgtcacaa tcctcattgg ggactttcta agggcatgtt ttgtgaggttttgcaattat
283681 tgctggtgct gggacttgga gtatggatat gtaagtatga tgttaattttgctttttttt
283741 ttttttaaat ttatttattt tttattgata attcttgggt gtttctcacagagggggatt
283801 tggcagggtc ataggacaat agtggaggga aggtcagcag ataaacaagtgaacaaaggt
283861 ctctggtttt cctaggcaga ggaccctgcg gccttccgca gtgtttgtgtccctgggtac
283921 ttgagattag ggagtggtga tgactcttaa ggagcatgct gccttcaagcatctgtttaa
283981 caaagcacat cttgcaccac ccttaatcca tttaaccctg agtggacacagcacatgttt
284041 cagagagcac agggttgggg gcaaggtcac agatcaacag gatcccacggcagaagaagt
284101 tttcttagta cagaacaaaa tgaaaagtct cccatgtcta cttctttctacacagacacg
284161 gcaaccatcc gatttctcaa tcttttcccc acctttcccg cctttctattccacaaagcc
284221 gccattgtca tccgggccca ttctcaatga gctgttgggc acacctcccagacggggtgg
284281 tggccgggca gaggggctcc tcacttccca gtaggggcgg ccgggcagaggcgcccctca
284341 cctcccgggc ggggcggctg gccgggcggg gggctgaccc cccacctcccctcccggacg
284401 gggcggctgg ccgggcaggg ggctgaccac cccacctccc tcccggatggggcggctggc
284461 cgggcagagg ggctcctcac ttcccagtag gggcagccgg gcagaggcgcccctcacctc
284521 ctggacgggg cggctggccg ggtggggggc tgaccccccc acctccctcccggacggggc
284581 ggctggccgg gcggggggct gacgccccca cctccctccc ggacggggtggctgccgggc
284641 ggagacgctc ctcagttccc agactgggtg gctgccgggc ggagaggctcctcatttctc
284701 agacggggcg gctgccgggc ggaggggctc ctcacttctc agacggggcagttgccgggc
284761 agagggtctc ctcacttctc agatggggcg gccgggcaga gatgctcctcacctcccaga
284821 cggggtcgca gccgggcaga ggtgctcctc acatcccaga tgatgggcggccgggcagag
284881 gcgctcctca cttcctagat gtgatggtgg ccgggaagag gtgctcctcacttcctaggt
284941 gggatggcgg ccgggcggag acgctcctca ctttccagac tgggcagccaggcagagggg
285001 ctcctcacat cccagacgat gggcggccag gcagagacgc tcctcacttcccagacgggg
285061 tggcagccga gcagaggctg caatctcggc actttgggag gccaaggcaggcggctggga
285121 ggtggaggtt gtagcgagcc gagatcacgc cactgcactc cagcctgggcaccattgagc
285181 actgagtgaa cgagactccg tctgcaatcc cggcacctcg ggaggctgaggctggcggat
285241 cacttgcggt ttggggctgg agactggcct ggccaacaca gcgaaaccccgtctccacca
285301 aaaccagtca ggcgtgtcgg cgcgagcctg caatcgcagg cactcggcatgctcagtcag
285361 gagaatcagg cagggaggtt gcagtgagcc gagatggcag cagtacagtccagcttcggc
285421 tcagcatgag agggagaccg tggaaagaga gggagaggga gaccatggggagagggagag
285481 ggagtaattt tgcgcttata aggtttttcc tttgtaattc gtcatttacacacactatat
285541 aagagaaagg catcatagag tttagtggat gggatcaccg ttttaggtgcaataaatgaa
285601 gaccaatgag tacatttata atgcagagaa gttcagactc gagtatcatggtttacaata
285661 ttctagtaaa attagcacaa gatagcaaaa gcaatggacc tcaacttgtcagctgaaatg
285721 ttgaactcag taaatcttgg ccctgtagcc caccttctcc ctataagtttactagcattt
285781 ctagaagcag ggaaagatgg ctaatatcaa ctgcatattc tatttatgcctttgaattct
285841 actaaactcc tggatactat catatgccag tcactgtgca gtagatggggtggataaaag
285901 gatttgataa atatggtact tgcttcacaa agttcacagt ctaataagagctcgaaagag
285961 acacacacaa gaggctgcag aaggttcaag gaaggcctag tttgctgtcatgcatctggc
286021 aagtggtgga gctgaattct ggcaggggcg gcttcttttc ctgaaacaatggctcaggtc
286081 tctcagaacc acactggtgc tgactccatc accagctttc cttctatggtcatcctcagg
286141 tcccccaaca aagtctgagg gcaacagcac actcatcacc ctgtgattagcacattgcct
286201 ggtttccact gtcctccttt gagtcaaact ggtctcagtc atcctggaaaatatgacctg
286261 gggggttggt agtactcatt tgcttaaaat cttccagtgg cttctcaagtacttagaatg
286321 atttccaaat ccctttctag gccttcagta ccctggatga tctgctccttttctttctct
286381 ctcaagtcat ttgctacctc ttttgctctt gctttgtaaa gttcacatgggcttcttttt
286441 atgctcaaac atgggctgct ttttatgctc aaacacaaga tggtccttgcatttgtaatt
286501 gctgtttctc ccgcaagggg tgctgttgcc ctagagctag gaatggctggtttcttcttg
286561 tcattaaaga ctcagctatt atgttacctc cttagtgctc ttctctgaccacctattcta
286621 atgtagccaa tcaggcactg tttatatcaa cacactgttc tgttttcttcataagatgtg
286681 catctatttg acattactct tgtaaaatgt actcatggtc tatctccctctgttagaaag
286741 aatactctat gaaaatagag gccctgacct ctcttatttg aactgtgtgagtcacgtagc
286801 aggcagcatg tgttggctgg ctgtttgaat gttgaacctt ctcatttttgcaccatcaag
286861 gcagcactgt ctattgccag aactctgcct ccttcgaagc atgtgcccatggagtctcag
286921 tgtttgtaat gtttttgagt tattgagcca gtaatgcttc tctcctcaccagtgagggaa
286981 tatcctttat agctgatctt ctatctcttt tatctcctgc cctctagtctctggatgagt
287041 ccaacagtta ggactgtttt caagatttca ggctagatct gtctggctgtctgactttga
287101 gatggtacct tttataaggt cgtctccatc accctcattg aaagtgcctcctcggactgg
287161 ccaaaagcag ttaggtaatg ctcttcggtg aacgacagtg aggtaatggctacagataca
287221 ggatgctctt gtgttgcttt cccattcttt gctatgaggt attcagctggcttggtttca
287281 tttctatttt ccttacctga ttcagctcct ctgaggcaga cataaaaattgccatttctt
287341 ccttagacca ttgcttggct tgtacttacc ttttatccct tggctgccttcttcttaagt
287401 ggcagaaaat ctgagtgcaa atatgaagtc aatattacat gacctggatgcataaaagct
287461 gtaattaaat gactgtaatt tattatttat tgactgctga cagtgttcctgggttagtag
287521 aaagtacagg aaaaaagaca agttcctgtt ttaggtcaca gagaaggaattttctcccac
287581 gttacctttg gaaggctcaa aaaagctctg tcagaatcaa aacaagttttaaaacattaa
287641 tgatggatga cgaatctttg atgtagatcc cattgtcatt gacttaccaaatggatagct
287701 tacacgggtg agggcctact aggtgcaagc cattatgaac aaactctgtgctaggtgata
287761 aaggaataca gggatgtaga agatgtagac ttacgtagag gttgcaaatttggcctgcag
287821 ggtagattca gctaatggat atttttgttt ggtatgccca gtggtggtgtttgtttttgt
287881 ttcatttttt atgagctaat attttaaaat gagagctctt acataaaaacacatggattt
287941 attgtttttc ttgaaaggct ggcaacatta aatctgtatt cccactagggagaaattggc
288001 tggagttgag aaaccactgc catctgcagt tgggatattc attctccagttcctcatact
288061 cttcaccact cttttctctt acaagctccc gatataaata gagaaatcaattgtatggcc
288121 cttgaagaga aagtgtgtgt gtgtttgtgt gtgtgtgtga gagagagagagacaggcgtg
288181 catcagtaga aatgcagaca cagaggagga gacatttgaa ctaagtcttgaagaatgatc
288241 aggatttcaa gagatgaaag aaagaattcc cggtggaggg acaagtgtaagacagagcac
288301 cagagataga tagtgtgggc aatccaggca tagattaaaa aaaaaaaaaaaaaaaactaa
288361 aatgaggctg ttttagagca gaaaaggcta ataagaatgt ttctctgctattctcctaga
288421 cctgctaatc aataatatgg tttcagaaag tacctgtcat gaagggaaggacaacctgag
288481 ataggcagag gacatacttg agaattctgt cagaaataaa agataaaatcatggtccttt
288541 ctactgtatg catgcatgtg catgtataca cacacacaaa gcacatgatttttttcttct
288601 gaattccaaa aataatgcca gtttattgta gaaaatttgg aaaatataacaaagctaata
288661 tgaaagtaaa aatcataggt aatctctgcc actaatgaga ttaattatttggattgttga
288721 atcaaatagt gttagataac aagtgctaca tatttatata tagtaacagatttttataaa
288781 tatacacata tatacttttg tatacgtata tatgtgtgta aacaggtagtagagtagact
288841 ggttacttgc ttttatttgt tttacctaac actgatcatt tcccaatgctattaactgtt
288901 gttttgtaac atacctttta aatggttgta taatattctg tatgcaaatgtagtataatt
288961 aatctaatta gtttttaatt tgctttaagt tgaactgtct aattattcttatgataataa
289021 gtgttgtgat gacatttaat tatatccatg tacataagta tcttcatagataaatcatag
289081 tggatgtaca aattattttc ttatgataaa tttctctgag ttgaattgctcagtcacagt
289141 agagggcttt aaaaaagtct attcactttt attacaacag cctctgtagagactctgcag
289201 atttcagcat tagattcaga gatctataga atgctaaagt taggtggattttgacacaac
289261 cagttgtaat gcatgtattt aacatatgaa aaattgcatc tgtgaattgaaatgaggttc
289321 ctaagtttat gtagccagag aataataagg acaatgaagt acacttctggacgaaaatgt
289381 tatgttaaat gtattgattt ctgtactggc tctatctgag taagctgggttaaaagggat
289441 tgtgaatatt tttcaagaca caaatttatg gtcataatgt tatcacaacaaacctatgaa
289501 gattaactaa ggtggaaaaa ttactggctt ggagcagatt accagaccaatgtaagttaa
289561 tgtaatgtaa gttaatgtct ccaaaggctt ctctgagcac agttctcagtgtttcagaag
289621 agttcatgag gagtagaata gtttgtccct aggaaggatt ttaactgctctaatttaata
289681 caaagtgtgc cctcttgtaa actttgggtt ttctttggca gttcaatgcagaatatcttt
289741 atcttcactt cagttttcat tgacaccatt cttactattt accagcaaagcaagtaaaga
289801 atattcaaga agaaatagaa ttagattcag ggcatgatgg ggtaagggaatgttcaataa
289861 actcagcatg gtgttcacag ttgtattttt aaggtgatca ttgctcactcgtaagtgaga
289921 gccgaacagc gatgggagac ttctttaaag tctgatgaag gatgctcaggattatccata
289981 aataagaggc atataattga ctgactacct tagtggattc ccaatcatattatattgtat
290041 tatgtcacat ctcaatgtac tgcttatttt gtatcagaaa ctctacaaaatactttacat
290101 gtattattcc atgtgatcgt accagcaatg ctgtgaggtg gtattattgttcctacttta
290161 cagtaaactg aggcttagag gatgttaaat aattgctcaa agacacattaatggttagtg
290221 gtagagttag gcctgaaact cgagtctcat caccttcaaa gccatcaaccaaatttccat
290281 catgttgaat ttacaccgta atgcttgact ctagaaattt taaaaattctgccaaaactt
290341 gaataattca tacactaaac ctatggcttt tggaactcaa agtgctcataggcttaggca
290401 ggctacctgt ggtagaatgg agttagcaaa tgaactggga tacagaattagaagatcaac
290461 tgttctctag ctgggaacgt ggagatatta tatatcagtt cgggaaggtagaatgataaa
290521 gaatcaggaa gaaatcatca gcatcccata aggggttgag aacatgggaacagggacaat
290581 gcagactgta ttttaagtgt tccttgaata tgtggacagg atctgtctgcagttaacagg
290641 atcctattct caactagggt tgaagtacaa agcctcaagt gctcaatcatcctagcagac
290701 gaggctagag tttgtcctag atcagtgctt ctggaatttg agcatacatcagaatcccct
290761 gaggacctgt gaaaacagca tttctgattc agtagatctg aggccaggcccgagaatgtg
290821 cttttctgac aagttcccag gtgatgctgc tgactctcgt ctgaggaccacactcaaaag
290881 ccactgctct ggagccacag cccagactag cttgcagctc taagcagagtgattccagct
290941 gtgagaaatg ggatttatgt gcagaaggtc aggcaactca ttccacaacagaattaattc
291001 tctctgagat cctgaattgc atttcatatt atccacaggt tggcaatctgcctcaaataa
291061 tgaaacttgc agagagagaa gagatcttcc caggcttttt ctttgtcaagtgagcaccat
291121 atgtcttccc tctgggtgga tgactgactt agcacatcac aagcaaaggtccaaaaatta
291181 aacaacatca tttccaatcc ctcaactatg atggacttta gcccaaatccacatgggctt
291241 ttctgatgct ggcccccaac agtcttacca ggaatgagca gtcattagtgagtttattac
291301 acttagctca ttcaaataat tttatgatct caaagttcaa gagaatctgtttttttttct
291361 ttttccctaa ccgtttttta cctttgagct ttttctattt tagagacaaacaaaatatat
291421 tgcaaattga tttatattta ttaaagtatt gctttaaaaa tttaaaatataatataacct
291481 aatgtttata aaagcctacc tctaaaacaa tgagcactga cttttatactacatatgtgt
291541 agtttttctg ccttctcttt tgttttagtt ttaaagtgag agcttctgtgtttattgcat
291601 aagttaaatt ccatttctaa ggtgtttaca gagaagcaat tctttcataactggttctaa
291661 ttttcaacca ataacgtatt tttagactag aaagggatct tagaaatgaactagttcaga
291721 ggttggcaaa cttttgctgt aaagggctag atagtaagta ttttagcttttgcaagccat
291781 ggtgtctcta ttataactgc taaatgctgt tgttttagta ccagtcatagataatatata
291841 aatgaatgaa tatagctgta ttccaataaa atttatttgt taaaacaggtggcagtccag
291901 atttggcaca tgggccatag tatgctgacc tttggtctag ttcatttttgatttatgtgt
291961 caggaaacta agcctaatga gataagtgac ctgcccagct tacctagctaagaaatggta
292021 gagtgaagtc taaaatgcag gtttgaatcc cagtcaaatg tctgttctacaaatccactt
292081 ggtccagtat ggccaccctg tatcctttct gtgcatcagg ccaatttatagatcaagggg
292141 gttgttcctc cagctgtccc tgctgcaaac acagcaggaa gctagggaccctagggtgtc
292201 ctttatgctt ttctagtcaa ctagttataa aatgtctcat ctctaatgaccctcaggagc
292261 tctatgtgct tgtgagagag tgaagaaaac aggcatttaa aacgttgagttttctccacg
292321 ttcagtagtt tggtgggcca cctcatgata ccattctaag gaggcgaaggcttaagattt
292381 gatttttaaa cagagacaga gaaaggctgt tccaaggcaa cagatgggtacgggccaacc
292441 gagtaagcat ttttcagatg tgttctgtga tcacacaggg ctccaggggaaaagtgctga
292501 agatcatcca gagcagggca ctcccccaga aggaaaaaga ctcagagttaatgttctcca
292561 gataagaagc agttcatttt tctccatgaa ggacacattt tttttccattgatgatttca
292621 gcacaaaaac tgtcaaccaa acctttttgc ctcttgtgaa cattgcccttctagaaagtc
292681 ggcaaactaa cgaaacactt tgtagctgtc cttcaacagt atctagagtgatactgcagt
292741 tatccaggtc atctttgttc tgtttaatac acaggactct ttattatttcattatgtatc
292801 atcctatcat tttaccttga gggttaacca ttcctgttat gccatacttgctcttctttc
292861 cctgaatctg ttacaaggga gattgtccct atgtttcagt tgaataggagagtaatactg
292921 ccttttagga aagtgatgaa gttgaggcct ggattcatga gactcttgaggccaagcatt
292981 tgaaaattga gaatggtttt gttggagttc caaatcagga accaattctatctttttaca
293041 aatatatttt tgagttcttg ggtttgggag gaacagaggc tctcttggatcatctttgtg
293101 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttggggagggagct
293161 gttatgggga tatgtgtggt ctgaagcaca cctggagata ataagatctgagcagtgcta
293221 ggaacctgcc aatgtcttgg tgtctttttc gtggtcttct tggccctctcatttcgtatt
293281 tactgcattc ttattccctt attaccagtt ggtcagtctc ctctgattctctatcccaaa
293341 ttaaataaga gccagtttta ttgcccttgc taattagcat ttactccattgttagaatct
293401 cctgttagga tgcctaatgc atcaccagga agcctttaga tgggccaccctatcacagtt
293461 aaccacttcc attctattgg ttttttgtgg ctcctctgta caaaaaacagcctagtgttg
293521 ctgccctgag catgaaggtt aatatccaag acatggagac tggacattgaattgagtaac
293581 ttcttaagct ttttttatat ttcttttgct gtatttactt tatgttaaagttaattcaca
293641 ttttcattga aaaaattttt aatatgcaaa acttgaaaaa gaaaaggaaaactatagttc
293701 atcacccgca tataaagtat gactatcttg ctgattattt tccagtctttgtgcatagtt
293761 tcatatagtt gattaatgtg tggctttata ttttttgttt aacattagagcacagttttc
293821 ctcatgtaca taaatattct ttcaaaatga ttgtaattca ttgcaatatatcatagtata
293881 aatatactgt atatacataa ctaatgttca acacttagat ggtttcatcattgcttgtta
293941 aagtttatca tcacatcaga taattttatt aagacagatt ctagaagttttcttacagaa
294001 tcaaaaagaa taagattttt aaagctttta atatgtactg tcaaattgtttttctgaaag
294061 gttgctacag tttttactgt caccagcagt gtataaggga gcctgtcttgctgtactttc
294121 atagcattgg atgacagcat ttaaaaatga gtctcactgt gtttaaaaaaaaaaaggtgc
294181 tttctttgtt ttatttatat ctggttactt atcctagtga ttattctgctattgttgctg
294241 aagggaagta attgaaaccc tagccatgcc tatgcagaac aatttgcctttcagttttga
294301 ccatgtgaga cgctaatcca atgaacattg tgtctcctct agccttcatacaccgaattc
294361 gacatcagtg gcaacgtcct cgctctgatc ttcaaccaag gcatgatctggtaggccagc
294421 tgttggacag cttatcactt acagaaaagc ctcccaggtt atttttgcatacagcattga
294481 atcctggtgt tagaggagaa tacaatcggt gtctaactcc atatttacttttgcaaagtg
294541 gatgcctgta tatagtttcc ttttctttca tatcttaaat gtcagtcatcaaaggtgtct
294601 ctctgttttg caaagcactt cttcatcaaa taatgggagt ctgtgttctggttagcagat
294661 ttatttgagg actatatttt tatattttgt gacgccagga tctaatattaaaacattaat
294721 aattacatta ccacatgata agtatgaaat aaattaacat aaggcctttccgagagaccg
294781 agtttatttt gttgtcacta ctaaatatat ttaaaatgta acttatagctacttttaaaa
294841 ataatacctt atcaaatcca atagtttatc gagatgaaac gcatgttttaggaaggtcga
294901 gttaaaatat gatcttcatt ttgtaacttg ttttataggg ccatggcacatcagaattat
294961 tttttttgat gtgtgaaggg ttgtcatatc ttttatcaaa ttagagcattctcactgtaa
295021 acttgacagg ttaagatgag tcgatacagt agaaatcgtt tttgagtttaaaaactgaat
295081 cacgacatcc gattcatctg gggaccatgt gtcttggaaa tctgtcacttcagatttcca
295141 gcctacaagc agttacaata aggctacttt atcctgggga catgtgcctaagacaatatt
295201 atgctgccaa ccataccatt gtcctattca caagtgccgg tatagactcagtttttgaac
295261 aagtttcata tattgtacca atagatctgt cctgaattat taaacctttgggtgctgaca
295321 gacaccggac ccctctgcaa atgctaaaac cgtcttgctt ctgtcacacaaagacaactc
295381 tccagggctc catcgtcctg ccatgggatg actgttaaat tcctgtgcctgactaggtga
295441 atcaatatgg aaaagatatt ataaaaatat tgtttcctcc tttgtcaggtaggtttaaaa
295501 atctaatttt tattcccttc ctttctaaat tttccaagta tgactcacatgtccagactc
295561 actaaggaag gaaatgcatc ctacattttc caagcaggga ggaaagtcaaggtggcccga
295621 ggaacgtcta ctgacacaga agtaaaggga gcagcttctg tgggttctgagctttcattt
295681 cctggagttc aatttgctgt tatggcagaa aatggctaac acggctatgggagtaatgag
295741 aaaccactgt tctatcagtg gcttttacac aaagtgtcat aaatccttcaggcctcatgg
295801 gtaccattca cgcagacata tgctgcacgt cgattgtgtt ctttcagagttaagacaaca
295861 gattggtcta gaaatttgtt tttattgtca gaaaagctgt tataatggctgtcctgcttg
295921 gtttcactac tgattttgca actatgttag tccactattg ttcatattgaaattcttaaa
295981 tatctaacat gtttttccag ttctctcgtg ggcagatcca ttatcaaaatctctgcactg
296041 tctttttctg tttattaatt cttcagacag tggtcaagct tgcttctggctaatttgaag
296101 agaatattga gttttttgag catacaaaga tattcacaca ctttccaaagttccagaagc
296161 aaactgacca ttattctatt attcaccttc acgtcaatgc ttggcacaaatattcttttc
296221 ctaaccctag gaggctgatg agggaggggg atgtcatgta gagggaggtgtggggcaggt
296281 gtaatgtaaa attagtaggc tgactctgca caaaggtcct cacacacaatcgttccatta
296341 ttttatgaag catgaggata taatgcctga gcttaaccat tttctacagaaacaattaaa
296401 aatgtacggg gatgttttat tcaattccat tggcttgtga ctggagatattgaattactc
296461 ctttaggaat cgctgagtag tggaggttat ttacgcagat gttgttaacatcaacattta
296521 tagataaaat ccattttgct atgatttggt tgaatgatta gtaacctttatttacgcact
296581 tattttttga aatacacatg atagtttctg tgctaatatt tttaaatgatgaaagcacag
296641 aatatcttta tcatagcagg atattgagaa atggcagaga acacacagtgagagagaaaa
296701 tgagttttgg acattgctcc aacactgctt cactgggtac tctcccgccaggtttatcac
296761 ctttttttct tcactttctc agttgatcag atgtgaataa tttacctgacatgtacatgt
296821 cgctgatgta ataaggagag ttaaataaaa gaagctttca ttttctttgatcttccagga
296881 agaaaagaat tttataaggc taaagtgtta caatgatttt tactgacagatgatgggatc
296941 atgcctgggt aagggactta gtgagccgag ctgattagta atgcatgagtaaagatagga
297001 tgagcattaa cattcggata ttattatgcc aggacttatt tttctagcttatggctcttg
297061 agttatttgt ttaaaatgtc tttgtgatac ttattttgaa attttgaaatttatttatag
297121 atgtatacac aaataataag catatacata caaacaatgt gcacgtatataggtacaaat
297181 atatgtggtt ttaggcaagt ctcgattttg aattacgtgc aaaattatattttagaattg
297241 atcaggttat gcagcaatga aacaacctca aaatcgtagc agctcataaaaggaacatgt
297301 tcaatgtggg gtggaagaag agctttgctc ttagaactta ccttcactttagagacccag
297361 actgatggaa taggatccat ctgaaacatt gctatcacac tagcagagaatgaagagaag
297421 gaaaaccaca caggactttt aaagtttcta cccagcagta aggacctaatttctattcat
297481 actttattgg ccaaaacaag tgatgtcacc acctgatttt taggaagactcaaagtgtat
297541 tacatcaaca tgtattggta ttggggagta taatctagtg ctttgcaattctaacccatt
297601 agctgggact atcacttgct tacttgctca cttttttggc gttccctctctcttgctgtc
297661 ctgtaacaaa agtatactgt attgttttaa aatctgtctt ctcattagaaaaaaatagtt
297721 taacttccta caaagtcttt gttcaattca ttatggtaaa atatcattcgtatctattgt
297781 ccgaaatctt gtcaacaaga cagcccaaat tgtgacaata ttccacttttcaaataaatg
297841 agttaacttt gggttggcaa aagttcaatt atagtggaaa ctaatttcttcatctaaatt
297901 aaaaatgtct ctataatgaa ccaaatttac gttggattgg ctaaacaactattcagggag
297961 tacaaaatgc taaacctagc tataaatgtt gagggcttca ttatagataggacagtttaa
298021 aagacagggc tccccttaca tttttaaaat aagtgcacat atatcttctttttgattttg
298081 aaataataaa ttgctattta tattgattta tggtgctaat gaattttctcatccaagaag
298141 agtgaaactt attttgttga aataatcaac taagccatca agtaaaagtgaccacaccta
298201 agttgttccc acctaaaagt agtattttaa aatgcttata aaaactcagatgcacaaagc
298261 agagaattcc caagacaagc taaagtaaga aagtaaacag ataaactaaatttaaataaa
298321 tgtgtggaat tttcatctca aaaacctata agctagttat aaattttcaataaaacccta
298381 ttttaggagg cacaaacaca tcattgcaat tggctttaaa acaccatatcacctacaaag
298441 agaaaatgat caacatcaga aagagaaaat ttattttaat ttttttctttcattaagcaa
298501 aaaacttttt tcatttgtac agtcgtggcc cactgcaacc ttgacctcctgtcattaagc
298561 aaaaactaat tattcatgac agaagtgatt aatgcaaatg tacagtttttttgagtagaa
298621 gaagtgactt taagggttaa ttatttttaa caagttatat ttataggtgtattagtcaat
298681 gatataagtg ttggggaaag tttattttag aattagaaga aagaagtaaaacaattgtaa
298741 atattgttta ctctgttgta gtttaaattc actaatgata gtaggtatagttagttacag
298801 catcctttct atgaaataat tatgatatgc aattcctaca ataatggggaaagtggcaaa
298861 atgtgtttag aagttggaaa tagataagtg cagtttcttt atgaaaagggtttgtctggt
298921 tgaaagtggc agtgtatttt ctgcctttgg aaaagaagca tgatgtcaaataaacaggtg
298981 cagtgtgact ttgttatgga gtaaagactc aaaactgagc agagttctgttttctttcta
299041 ggatgggctc cttctttgct cccagcctcc caggcatcaa tatccttcgactccatacat
299101 ccatgtactt ccagtgctgg gccgttatgt gctgcaatgt tcctgaggccagggtcttca
299161 aagcttccag atcaaataac ttctacctgg gcatgctact gctcatcctcttcctgtcca
299221 caatgcctgt cttgtacatg atcgtgtccc tcccaccatc ttttgattgtggtccattca
299281 ggtctcttgc ttttgaaatt tgactcaggc atcgtgttct ttcgggggtggaggtgggaa
299341 tggtcattca ttgtataagc tattttttcc ccccaaacaa tgacatttttggttggtgga
299401 aatgagatcc cggctgggcg cagtggctca tgcctgtaat cccagcactttgggaggctg
299461 aggcaggcag attacctgag gtcaggagtt cgagacaagc ctggccaacacggtgaaacc
299521 tcgtctctac taaaaataca aagaaaaaaa aattagtcgc gtgtggtggtgggtgcctgt
299581 aatccctgct acttgagagg ctgaggcagg agaatcactt gagctcaggaggcggaggtt
299641 gcagtgagct gagatggtgc cattgcactc cagcctggag gacaagagcaaaactctgtc
299701 tcaaaaaaaa aaaaaaagaa agaaatgaga tcctttgggt attcaggttcaataggtgac
299761 atggagattc ttaggcaagt tctgtctatt tcctcatttg ggaatcataaaagagaaaat
299821 actttatact tttccaggct ctgcctgggt aaaatatgta tggtgaatctgagctgtttc
299881 catgttagag gatagctaag agcaaggtct gatgacagtg gtctggatgtgagtttgcct
299941 gactctgggc cgtcacatcc agacgtggtc agctatcact acttctcttgtgcattacta
300001 ccttaaaaag agagagagag agacagacag agagagagag aataccccacactttaccta
300061 ggaaagagaa ttattactaa atactaatga gcataaggag ggccacccaatttgttatcc
300121 aaaatatcac atgctagtga aaaaaattaa ggctgttcca catatatattctctcctaat
300181 tatcattcaa gtcaggaatc gagagtcaca acggctcctt gatccaatttagagatacac
300241 atttctacag ttctctatga cagagctctc ttctctctat gacacatatcagaaacctaa
300301 gtccctggga tctggaggat gaagtttctt tccctaaagg gccttagaaatgaatctact
300361 acaagttctc ccaagaatct ctgcatgttg attcactggc cagcatgcacttgagctgtt
300421 tctccttttc agtgaaggaa atgagactgt aaaaagccat gtgaatgatatgcatgatgc
300481 tgtaatgccc acatataatt cctccattat gttgtcagac ccaagttatttaattaaagt
300541 caaaaggttc attgctgaca gactaagtat ataagagaca ttttcactcttaacagtagt
300601 ctgagttatt gctttgctgg aaaacaagaa aatgttaagc cagctgatcgagttaaacta
300661 gctggacctc tgtctactca gagaactgat gttgagaagc tctgttaattccgttgtgtg
300721 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tttccaagtgggctgaaata
300781 aataatgcag acagtgacat ctggagacta aatatgaaat tacagtcttgatgagacatt
300841 cgtctcaata aattccgaac caatctcaga gtacaaagtt caaggaatatgccattcaaa
300901 ggctttagtt aattgcaaat tattcacact acttattatc caggataagtttaggtgtgc
300961 attaagctat taattggaag ttgatccttc tcagtaaaac atagcaaaggaccctagctg
301021 cctgtaaggg aaaccacaca atgtaaacat ggatctccac agatgcattcagatttacaa
301081 tacgtcttag acatgaacaa tagttgcaca atttcagctt cttaagccctaactcttctg
301141 gctttcctaa ttggcaaact taggcaaaat tatggcatgt aaatcactattttgaaatca
301201 gggaaattta ttttttattt ttaaaattat ttatttgttt tttaatttccataggttatt
301261 ggggaacaag tagtgtttgg ttacttgagt cagttcttta gggtgatttgtgagaaatca
301321 gggaatttta aatattttca atggagtact gggaagggtt atctctatgctatttagatt
301381 ttttttttca tgtcagtttc ctcactttag agccaaagga tgtttgcattgtttatttgt
301441 ctggacttaa aagtttgaaa ggattgtcct gctctagaaa tgaggtgagaatgcttgtat
301501 gcttgtacta gtgggtgcct catagcttgt catctttatg aaccccaagttttaggtgat
301561 ttgcttaacc ttcctggtga aggttgtctg actctatcta gatcctgggcaagcaggaat
301621 ttaggaaata taaatttgaa ctaggttact ggaggtatca cagtgatggctagttgctct
301681 ccagtgtagg gaagttttca ggtaagatgg ctatagtata tttatccattcagtaaagca
301741 atttgatgag atattctagc ttgtctggtt ttataagacc tggctagagagggtaaattt
301801 tccaagaaat tattccaata ggctagtaag tggatttatc gtaaatagttgacaatttaa
301861 agatgtccag atgaaggcaa ttctaattgt tctatagcat ttcctgacacctgatgtttc
301921 ctcccatcta tgtcaataat tctgaacaat ttatagttct ctaggtttttatatacatcc
301981 ctgcttacat tatgacaatt ttatttttca tatattttca tcttactgcaaagataatat
302041 gtgtttatgc tagaaaacct aaacattgta gaaatatttt tacatgaaaagaaacatggc
302101 ccataatctt gaaaacctga aataacaact ttttagcatt ttatattctgttttgccttt
302161 catgcatgat ttttcataac tgagcttgta ctgacacagg atgtttctcagcctcttcac
302221 tggactcaca gaggggcacc ctgtctactc ggcctgctgt gcttaaccccttgtgggagg
302281 aagcacgtgg gcaagtgagt gcgggatctg gcgagacaca ctgggcactgacacaggagc
302341 aagctccatg tggggcccgt ggccagacca ggtgtgtcac cttgaggagaatgcaatggt
302401 gcccaagtgc ctatgaccct aaagccccag agggggtgtt acaatgcttcctgagttcca
302461 ccatcctcag cctgatggat ggcagtgtct tagcagctca gttggccccttgcctcatca
302521 tgtggggcag ctgccctcca ctggagaggg caaagggcca gtgtgacagtctttcctggg
302581 ttcccacaat cggtgggtcc caagctcttg tccagcatcc aagaagaatgaggtcacatg
302641 gattattgaa ggatggtgaa ggaggagaat tttattgagt aatgaaattggctctcagca
302701 gagagggcag ttggagaggg gccaggaagg gcaggtcatc ttccccaaagtcaggttgtc
302761 tcttctccaa agtcaggccg actcttcccc aaagtcaggc cgtctctcccctctaccaac
302821 tgagtctgtg gtctttatag gcacaggatg gaagtgtgtg ctgactggtttgtgagtatg
302881 caaaaaaggc taaagtgaag gtgtcactca aaggtagaca cgacagtatagaaacccaac
302941 taggaaaggg taggtatatg taaaataggt gaagggtggg gatgaatcagaggaaagtgc
303001 gccaaacagg aagacaagtt ctcaatccgg tctgaggatt taacttggaccttggctttc
303061 aggctttaaa ctgtctttgg cttggaggtg gcatttcacc aggtacctgcccctatctgc
303121 ctaggcattt ggctgcctcc tgttgctatc agtatactag gtgcaggttttttagtatta
303181 aaagttaaaa ttatattgtg agactgctat tatattggtc atttgcaatcatgctttatg
303241 catctatttt tcttaatagt ttagctgact tctagagatt ggggatagagaagtttcctc
303301 tctgtggatc taggacacag taaagtgctg gtcaataatt tgaatgaatgaatgaataat
303361 gactgcttat tgtgcactaa gcactagaag agacacaggg ttaagtccatgcattaagca
303421 ttgattctgg tcctgtggca cttatcaccc agctgggaag acaggcctcctcataaactg
303481 ttctaatcta gagtggcgct atgcctacag caggactatg gatagacacagacaactgga
303541 aaacaattct gagaatattg tatgatagca tactttggct aacctggcaggagaaggcat
303601 tgccagggac atgtagatgc gtccataatt tgtacgtaat taagatatctggactccttt
303661 ctttggtaaa agacctgacc tgaaaaaggt acacaggaat ccccagggacttagcaactt
303721 tgctttgggt cacactggat gctgagaagg cctttgtgtg tagggataatttcataaaat
303781 ttgaatgccc ccactctaac tacgttcatc agctatgacc tgaggtgctggagaagggag
303841 gatagatggt cttatctttt ttggtacttt taatttatct gcttatcctgtattccatct
303901 ggctggggct gcattggggg gtatgaacaa tttggaatgg tgaaaaataaaacatattgg
303961 aatagggagt tataatctta tattgcttgt aagcttcatt ccctcttatgtatcataagt
304021 cttgaaaatt agagtgtaga tctttaattt gtgaagcaaa acttgtacctctgtagtcca
304081 atgactactg acaaaatata tggagtcact atgtctgctg gaagatagtattggttagac
304141 caggagaaaa aaaccataat ctgggacttg cgtgtcattg ttatttagtagttgaaaatg
304201 cttaaagatt aaaatacaaa agcaaaacta aacattgtat taaatgttgcaccaacattt
304261 attctgatga tgcatacaat ttggtgaaac ccaacccaaa tctcttctgaaaattacatc
304321 ttttcgtagt acaatcagta tgcatataca gagaaaataa tgatgtaatgaatattttga
304381 atattatggt acaattctag ctattcctta gtaagtcaag acatcctgttctcagttttc
304441 tagtttatag gagctgatac ttgccttcat ggagcttagc agtggagctaagctggtatt
304501 cattagggcc tgtccaggag aagaaactga gagggaaaaa acccatgattcggtgtggtt
304561 accttaccta ttaacatatc tgatgaagga agtctggtgg aaaatgaggtggaagctatt
304621 gcgtggaaag agatattgga ttatatgtgg attttattcc actgggctattccttgctct
304681 catttccaag gctaattaaa aatacttagc tcaaagagag tgttctcctacaagagcagc
304741 tgactgagag gcagacttat gagctattta caaaatatat ttcaatcaaaatcttagaaa
304801 tacagttttt aaaaatcttc tcctaaatat gtggttaatt ttctaactgctttgactata
304861 tgtttatact gggatcatat ttctcgtatc ttacccatat attgactacatgaggtcaaa
304921 gtgtcagcaa gttgtagcta aacatcagat tcctaccctg aaagaggacctaagcagtaa
304981 ttgagaaaga tttccagttt tcttgcttta accatggttt ttccatatgttcttaataaa
305041 cttatctccc cctttttaat tcccccagtg gcaaaaatag aatgtttgaagtcattggag
305101 agaccctgga gcacgatttc ccaagctgga tggcgaagat cttgagacagctttcaaacc
305161 ctgggctggt cattgctgtc attttggtga tggtgtatgt gcttttcctcctcatagaaa
305221 gagcctctgt gatgttcttc ctggctgttt ttacatttca gctttttcagctctctcact
305281 ctccctaagg gttctgctgt aacctatcca aattcaacac tgattacatggtggtgagag
305341 gctaaaattc atgagccata ttctgatcct attggatgta attcacaggcatctgcatct
305401 gtctttgctt ccccaggatt ataagatttg ttcccaagta accacaataattatccataa
305461 acagctaaag caagggaaac ataaatgcta aatgctaaat ctaatcagtacattgagctt
305521 ccccccaaca acccggcctc cacctctcgt tccataaagc agatggcaatgaatatacag
305581 aaataatgat cctctaagtt aatattcccc ttgggggccc tatagactatattttagggg
305641 caagggcttc aagggtctta aaaatttcac tgtccttgtt gttagagggccgccaataac
305701 tgtgtgttca cgataataga atcagaggac cagaggatct tgggaagttcctgtagtctg
305761 tcccttcaaa gtcagaagtg atttccaaag gggaacttgt cagatgacttttgttttcac
305821 ataactttca ttggcttctg actcttggcc atcacagata aacttagattctaagtaaaa
305881 gtacagattt gctgtggaag agccaaaagc agcgtccatc tcttcctttcagtccctgag
305941 tgcctcctac atagaatgtc tggagctgcc acgactctca gtcagtgggtaaatattaaa
306001 cagccccagg gacactttaa gaacaaagtt gatgcaaagg atttggttcatttaaataaa
306061 ggtaaaacaa ggaaatctca gggagaaaac tcccagtggt ttgcagtaaatgagcaggga
306121 ttgtgaccca gttattgtcg tgatcacaag ccacataaag tagtgagggcaggtttatct
306181 tcttcaattt tataacctaa gaaattgatt tacacaaaga aagtgattttccctagacaa
306241 gagagagagt aaaatggtca tagaaggacc tgaagcagat cctttcacagtaaatccagt
306301 gctcacttct ttatactgcg aggctttctg tgagggagag ctaataacctgtagggataa
306361 ttaaacagta aatcagatta ccattatata ttacataacc ttgataatggggtgctatta
306421 agaatctgat agtaaatctc tggcacagat gcattagaaa atgacctactgaatgcagca
306481 tgtttcacca gatggccttt gaaacaattt tctttctcta catgtccatgatacagtggc
306541 ttctgagagc atgttaatca gtatcctgtg gcctttgaga gtcaaggccctttagtggta
306601 tgaatgaggt gttgtttaaa acacacacac acacacacac acaatgtaaatgtcagattt
306661 cgttaccata ttcttacttg attaggagac atgtttattt ttaagtgaaggagtggcatt
306721 gttcaaatgc cttaatccaa agatttagta atcagtccta agagggtttaaaaggaattc
306781 acactgcctt tgtttcaggt actatttaca cactgactca tttaattcccataacagctt
306841 tgagaagctg gcttcattaa tcatactatc aataacacat tgaaattctgccccaagtca
306901 agtgactaag tggaactgaa actcatgtct tctccttatt tcctacactcacttgcagca
306961 ccaaacaggg atcagaatca gtgggaattt cagatgggct gaaagccacttgtccgaggt
307021 ggtatagacc cagggtcagc acacttttcc taattcgagg gccagaggcaaattaggcca
307081 agaggcaaaa ttgaggctct taattaagta attactaata ataaccgtttaaaagacaga
307141 aaaaccattc ttaattcatg ggccatacaa aacagtctgg cagtcatcttcatcctgcag
307201 gacctagttt gctttgatct ggacagcctg gaggaaagct ggccccatgcaaatgtcaaa
307261 tagatgtact gaaaggttga ttgtggctct gaggttctga tttaaaacccagattttagc
307321 ttattactga gtatattttt tcaaattctg agatctcatc ttctatttttggggcccata
307381 caattggctt agctttttat tacctttaat tagagaattg tactagtatgttgaatttcc
307441 cccaatggat tatattaaat caacctggat ggctttcggg tatctaagcagagttcaggt
307501 tagttctctg caggcagttt cattcctttg gagactagaa aaagatttgtgaggaatact
307561 tatttaacgt gcattacaag gtagaaaatc atggtggata aatagagaattccagaactt
307621 gaaaggactt gtgaaatctt tgagttcatc ttccaaatcc aggaacttttctaagaaaat
307681 ccttataata cacaccacac acaaacacac acacacacaa acatttattgagcacctatt
307741 tcatgccaga tattgccctg catgcattta tgtatgtaat tttagtaaaactcccatcac
307801 tcatgtaaga gataaacaaa ctcagccaaa ccgtatcaat aattgtgttgctagcaccag
307861 atggttcata aaggatactg tctttcattt tggggagtag aggaaatgtgttcaatatcc
307921 agttatttgc agcaaagagt aatataagtt acctttttta ctgcatttcttctttgtttg
307981 tttgttcgtt ttgccttaag tgaagataag catatttatt tttacagaattgtctggcta
308041 gaatttgccc tttctagaat gtaaatgtca tttaaaatcc aataatattcctttatacaa
308101 cgttttcttt ttgagggaga aagaaatgca aacaatacat tctacggaaaaaattccatg
308161 ttcattatct atgcctatga ggattacatt cttagctgca aaggccaaaggacgaaattt
308221 aaggcagaaa gtcgttttcc tttttgttcg gcatgttccc taagctgcagtaggttttcc
308281 attctctggg atgccattgc catccattta aaatgctact ttcaattataatttaaactt
308341 atgtgaatac atttccagga aaaagctaat attaggcagt gtgaaatagcagacagaaca
308401 ggctgtggat caggagcctt gggccccaac tttccaactt caccccagcttcatccctat
308461 gtcatcctga atgtatctct ttacctctct ggacctcagc ttttatctataagacaagag
308521 atttagagta gaagatagct taatgttcat tcccatgctg atatttcataatttacttaa
308581 tgtaaattta agaagtatct tggggaactg aaatatacct tacactgtattttttttctt
308641 tttaatttag tttggccatc tattatctca atgctactgc caagggccagaaggcagcga
308701 atctggatct caaaaagaag atgaaaatgg tatgatacaa tttatttcatagaaatatta
308761 tctttattaa tgtcaagcag tagaaaacac tgagaaatct acttttttccccttattttt
308821 tattgtgtag caagctttgg agaacaaaat gcgaaacaag aaaatggcagctgcacgagc
308881 aggttggaga tacgtttatg tttgtaatgt ttgtaatttt tctttttctttttctttctt
308941 tttttttttt ttttgctttt tctccattgg atggtgagtg gcattattgctgtgagcgag
309001 tcattccaca atccttacct tccacctttt tagcccttct caggcatcacatccagggta
309061 tttggttgtt ttctagtggg aggaaaaaaa gagaaatgaa aatgtgggcatataaacttg
309121 gcagtagtga tttttaaaag tgaccttgaa aatgcgcaga aaatgaagaaatcccccata
309181 tagtcgtcta caaacagcag atacaaatgc agatgctctc ctgcccatgttgactatttt
309241 catacatgga aggatatggc aagaagatcc caagagggtc ctctgggctttccaccactg
309301 attgccagaa gccctttcta atccattaaa ctttcttttt ttaaaaacctctttattttt
309361 taaagtatta gagtaaagcc aacttctagt tgccaaaatt aataatatgctttgagttcc
309421 ccacggaaag gtgataccta agacctttag tgaaaatctt ttccaactttgtccttactc
309481 ctaactttaa aactctttac attagtagga ctgtttcccc actgtaagtaataaaacact
309541 caaattggtt taattgagaa agagtaattt attcgaccac acaaatgcagggaaatggta
309601 tgtatggctt caggccactt tcttttttct atatatatat atattttttaattatacttt
309661 aagttctagg gtacatgtgc acaacgtgca ggttagttac atatgtatacatgtgccatg
309721 ttggtgtgct gcacccatta actcatcatt tacattaggt atatgtcctaatgctagccc
309781 tccctgctcc ccccaccgca cgacaggccc cggtatgtga tgttccccttcctgtgtcca
309841 agtgttctca ttgttcaatt tccacctatg agtaagaaca tgcggtgtttggttttttgt
309901 ccttgcgata gtttgctgag aatgatggtt tccagcttca tctatgtccctacaaaggac
309961 atgaactcat cattttttat ggctgcatag tattccatgg tgtatatgtgccacattttc
310021 ttaatccagt ctatcattgt tggacatttg ggttggttcc aagtctttgctattgtgaat
310081 agtgccgcaa taaacatacg tgtgcatgtg tctttatagc agcatgatttataatccttt
310141 gggtatatac ccaaaggatt ttttttcttt tttgagacct ggtctggctctgtggcccag
310201 gctggagggc agtggtatga tctcggctca ctgcagctcc aacttcccaggctgaagtga
310261 tccttcctcc tcagcctcct gagtagtggg gacagcgcac accaccatgcctggataatt
310321 tttaattttt tttttgaagt gaggtcttgc taagttgccc aggctgctctcaaagtcttg
310381 ggctcaggtg atcttctctt tttggcctcc caaagtgttg ggattaaaagcatgaaccac
310441 tgtgcccagc attcagggca ctttttatcc taagtttaga acagagtcaggtctgagccc
310501 acctctctgt gaatctctga agctaaactc ctttcacatt ggctgacctttatggcagca
310561 ggaatggatg cagcaacttc caatgccatg tccttagact gtaaaacttctttcctagaa
310621 attcctcaac ctctcctcct ttcagattgg ccccatatgg gtcatgtatccatccttgtg
310681 ccagtcactg tgtctgagta tggtaagtta ctgaagtcag tcaggacccatccttgaagc
310741 tgggattggt ctgttttcct gacacatgtg aaatgcactg gggaggtcacacctacctaa
310801 gagaaggaga aaaggatgct gggtgtcccc aaacaacaaa tgttcaagacttggttttgt
310861 tgccttcttt atgcttagcc ttttttcttt tccctctctc tatctagcatgcataaatgt
310921 aaagttgaat gctgggtgct gaattagatg attacagtga tgtacagttatcagactagt
310981 ttttaatgaa atttttaatt ttttaaatca atactacatg tgtgcataatttagagttcc
311041 atttagaatt tcataattct ataaggctta tcatgaaaaa cagcatcttcttctgcctcc
311101 tacaccagtt ttgctctctt ctcctcccct gcactcaaat accctaagacaaacactttc
311161 aatttgttag ttgattttta gatatttatc tccaaattac ctaattttgttgtaatttct
311221 tgacttttta gttttaagta ttatctctta aaattattaa ctacaatggatataataatt
311281 ttaatagata atatttaaac gatttttata ctcttgcccc agtctttctatgcattctac
311341 ctatgtagtt atattattat tttggttagg ccagtataca ttattatggacacacagtct
311401 tcacagctaa gccaagtagt aaactatgat acttgtgcat actttaaaattttctcagga
311461 ttcataattc ataatttctc tttttaaaca ttttcttatt tttatatatgtttcagtgat
311521 gcatttaatt tccaaatctc tgctatttat tgagttatac tctcaatatattcagacata
311581 ttgggttatc tgtccatttc atttccttag agaaatcttt cccagaatcttctgcacttc
311641 tccaatttca actagtgtgt gtctgggata cagctgtcat cctttcatttttcttcactg
311701 tcattcaaca ggatctctgt cactttatcc tgttttggat actgtgttttccattttccc
311761 caacttcctc tcttttggtc tgctcacatt ttgccagtaa gaaagggtatgtgagaggca
311821 aattttctga gaccatgcct atctgaaatt gttcttctct tactctcccttttgactgat
311881 agtttggggg tcaaaaatac tcatctaatt atattagaaa taatatcccttcaaaatagt
311941 attttttcag aggtttccca tgccttttag attccacaat tgctcttgagtagtttaaag
312001 ccattgtgat tcttagtctt tcttgagcaa cttgtatttt tgattatctgtttggttttc
312061 caatctggaa agttctaggg tctccttatc tgcatgttca gaatttcatgatggtgtatc
312121 ttgcatggat ctatttttat tccttgtgta ctcatcaatg gacttttgctctttggttga
312181 agggaatttt cttgaattgt ttacaaattc tttccatcca ttttctgttttttttttttt
312241 catgtagaat ttctaattta tttttcatcc ttaaattccc tttgtctctttgctttacct
312301 atgaacattt ccttatcttt aaattttaac atttctcttg gccttttcacttttgctatc
312361 ataattttag tttctgcaag ctgttttgtt ctttaattct tcttttttaaacagcatgct
312421 gtttttgttt aatggctgca atggcttgtt ttgtctttat gagaatattaataactcttt
312481 ttgatgtttc tttgcctttg atagtctgtt ttctctaagc tgttttgttcttctttctcc
312541 cctgcttggt aattcccctg ctttgtgacc ctcagctcat atttcagggtaggatgcaaa
312601 ggtgggtttc gaagctttaa gcacatggat ggggcttgtg ggcagatcctcattggggga
312661 ctctgcctgg gctgccgctg aacccccatg tcagtatttt taggcttctcctcttaagct
312721 gatcagattc ctcagaaaaa ttacttccga actcctgccc agagagtaaagatttgcctg
312781 gcaaatctgt agcacctgag tgggaaaaac aacacgggtg gggctcagctttcaacctac
312841 aaatgctcac ttagccccct ctttttactg cggcactcct tgtggtcttctaacccagaa
312901 gcatctctgt tttactcttt ttagaaaaaa ttattccagt cttctgccagattaaaggta
312961 gtgggggttg gggagcaatt attcatttgt accaagtgaa gccgatctcagactctaact
313021 gctgctgttt cgttttttaa taacccccac ccctttgccc caccaagcttgactgcttct
313081 taacagctaa aacatcctct ttgtattggt tccttacttc cagaggtacctgttgctgca
313141 aattactgaa cgtttcagag attttatgtg taaattatgt tgcttactgtctttttcctc
313201 ccctggctta gcttttcagt ttgttagaat tgataagtca ttatcattaatctgtctgct
313261 ttccagcttc taaaattttg tcattgatgt ctcttcccct attctccccctccttgcagg
313321 tttatgcaac cttctccatc ttcctcccca accccctcaa aatttcttgactgtcatgtt
313381 tgtgaaaggg tgaaagttca attcaatgta tttacctccg cagtttaggcaaacctttgt
313441 atttcctaca ctaggagaac aatggtttta tgtccatctt cactctgttcatcccacagt
313501 gcttacctga ggtattattt tgaaatagag tctgggatgg agtctaccttagtgagaatt
313561 tattagaatt gtttagtctc tgcagaagat gaggtggttg aagcacatacatcacatata
313621 ctagcagtgc ttttgtataa tttaatatta tcaaattagt acttaagaatggaaaattct
313681 gacttataag atctaaattc taattaaggc ttattgttat ctttattgttttaaatgata
313741 atataatgct atagcatgct attcatctga tattttttcc ataatgtgtatggccaccca
313801 gtaaacacct actgaatatc tactgaaaaa tgaggaactc ttttgttggaaaaatataaa
313861 atattcatca cataagcaat aatgtataaa tgttacaaaa aagtagtacattcattctgc
313921 cttgtttaga atatgtgaag cctttgcaaa ctaagaaaca tggaaatattttgaacatta
313981 aaatggtaaa tattatggga aagtagagca catttggaca atacagatttctggccacct
314041 cattcagaac cattaagcac actgaaagct acgtttttat ttgcctcctgttcatcttct
314101 ctctctctct ccttgttttt tttttttttt tttttctgtt ttgtgaacagctgcagctgc
314161 tggtcgccag taataagtat cctgagagcc cagaaaaggt acactttgccttgctgttta
314221 aaagtaatgc aatatgtgaa cgcccagaga acaagcactg tggaactgctattttcctgt
314281 tctacccttg atggattttc aaggtcatgc tggccaatta aggcatcatcagtcctacct
314341 gagcaacaag aatctaaact ttattccaag tcagaaactg tttctgcagagccactctct
314401 cccctgctcc atttcgtgac tttttttttt tttttaacaa attgagtttagaagtgagtg
314461 taatccagca atacagttta ctggtttagt tggtgggtta attaaaaaaaatttgctcat
314521 atgaactttc attttatatg tttcttttgc c
Pejvakin(PJVK)
PJVK基因编码“pejvakin”(PJVK)。PJVK是gasdermin家族的成员，是听觉通路神经元正常功能所必需的。PJVK中的突变可导致非综合征性感音神经性听力损失。例如，PJVK中的v.930_931del AC移码突变已与耳聋相关联(Zhang等人，Acta Otolaryngol 135(3):211-216,2015)。
人PJVK基因位于染色体2q231上。其包含8个外显子，涵盖约17千碱基(kb)(NCBI登录号NG_012186.1)。从人PJVK基因表达的全长野生型PJVK蛋白的长度为352个氨基酸。
示例性人野生型PJVK蛋白为或包括SEQ ID NO:51、SEQ ID NO:53、SEQ ID NO:55、SEQ ID NO:57、SEQ ID NO:59或SEQ ID NO:61的序列。编码野生型PJVK蛋白的核酸的非限制性实例为或包括SEQ ID NO:52,SEQ ID NO:54、SEQ ID NO:56、SEQ ID NO:58、SEQ IDNO:60和SEQ ID NO:62。
人PJVK蛋白异型体1(SEQ ID NO:51)(NCBI登录号NP_001036167.1)
MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKDILLGDREISAGISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVTKHEVEVSTLLKEITTRKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDLCVTSVSKGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK
人PJVK异型体1cDNA(SEQ ID NO:52)
atgtttgctgctgctaccaagagctttgtcaagcaagttggagatggagggagattagttcctgttccaagcctcagtgaagctgacaaatatcaacctctaagtctggtggtaaaaaagaagcgatgctttctgtttcctagatataaatttacttcaacaccttttacactgaaagatattctcctaggagacagagaaatttcagctggtatttcatcttatcaattactgaattatgaagatgaatcagatgtttcactctatggaaggcgaggtaaccatattgtaaatgacgttgggattaacgttgctggatcagattccattgcagtgaaagcttcatttggtatagtaaccaaacatgaagtggaagtatcaacattactcaaagaaattactacacgaaaaattaactttgaccacagcttgatacgtcagtcaaggagcagcagaaaggcagtattgtgtgtggtcatggagagcatccgaaccacacgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgcggtttcactttatggatgaacagaatcccaagggaagggacaaagctattgttttcccagcacatacaaccatagctttcagtgtttttgaactcttcatatacctggatggtgcctttgacctttgtgtcacttcagtgtcaaaaggaggatttgaaagggaagaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttgaaagaaatagaagagtgatggatgtcatttctcgttcacagctttacttggatgatcttttttctgactactatgacaaacctctcagcatgactgatatttcactcaaagaagggacccatatccgagttaacttacttaatcacaacattcccaaagggccttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtgctttcagtgttctgttgatggtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcacaagaggatgaaataa
人PJVK蛋白异型体2(SEQ ID NO:53)(NCBI登录号NP_001340704.1)
MAFAWDAAPLSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKDILLGDREISAGISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVTKHEVEVSTLLKEITTRKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDLCVTSVSKGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK
人PJVK异型体2cDNA(SEQ ID NO:54)
atggcgtttgcctgggatgcagcacctttgagctttgtcaagcaagttggagatggagggagattagttcctgttccaagcctcagtgaagctgacaaatatcaacctctaagtctggtggtaaaaaagaagcgatgctttctgtttcctagatataaatttacttcaacaccttttacactgaaagatattctcctaggagacagagaaatttcagctggtatttcatcttatcaattactgaattatgaagatgaatcagatgtttcactctatggaaggcgaggtaaccatattgtaaatgacgttgggattaacgttgctggatcagattccattgcagtgaaagcttcatttggtatagtaaccaaacatgaagtggaagtatcaacattactcaaagaaattactacacgaaaaattaactttgaccacagcttgatacgtcagtcaaggagcagcagaaaggcagtattgtgtgtggtcatggagagcatccgaaccacacgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgcggtttcactttatggatgaacagaatcccaagggaagggacaaagctattgttttcccagcacatacaaccatagctttcagtgtttttgaactcttcatatacctggatggtgcctttgacctttgtgtcacttcagtgtcaaaaggaggatttgaaagggaagaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttgaaagaaatagaagagtgatggatgtcatttctcgttcacagctttacttggatgatcttttttctgactactatgacaaacctctcagcatgactgatatttcactcaaagaagggacccatatccgagttaacttacttaatcacaacattcccaaagggccttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtgctttcagtgttctgttgatggtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcacaagaggatgaaataa
人PJVK蛋白异型体3(SEQ ID NO:55)(NCBI登录号NP_001340705.1)
MYVYRLLSITVLMDILLEGLHSQYFTIYELRITPMAKHFSTQSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKDILLGDREISAGISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVTKHEVEVSTLLKEITTRKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDRRVMDVISRSQLYLDDLFSDYYDKPLSMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK
人PJVK异型体3cDNA(SEQ ID NO:56)
atgtatgtatatagattactatccatcactgttttaatggatatcttattggaagggctacatagtcagtatttcacaatatatgaactccgcataacacctatggcaaaacatttcagcactcagagctttgtcaagcaagttggagatggagggagattagttcctgttccaagcctcagtgaagctgacaaatatcaacctctaagtctggtggtaaaaaagaagcgatgctttctgtttcctagatataaatttacttcaacaccttttacactgaaagatattctcctaggagacagagaaatttcagctggtatttcatcttatcaattactgaattatgaagatgaatcagatgtttcactctatggaaggcgaggtaaccatattgtaaatgacgttgggattaacgttgctggatcagattccattgcagtgaaagcttcatttggtatagtaaccaaacatgaagtggaagtatcaacattactcaaagaaattactacacgaaaaattaactttgaccacagcttgatacgtcagtcaaggagcagcagaaaggcagtattgtgtgtggtcatggagagcatccgaaccacacgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgcggtttcactttatggatgaacagaatcccaagggaagggacaaagctattgttttcccagcacatacaaccatagctttcagtgtttttgaactcttcatatacctggatggtgcctttgatagaagagtgatggatgtcatttctcgttcacagctttacttggatgatcttttttctgactactatgacaaacctctcagcatgactgatatttcactcaaagaagggacccatatccgagttaacttacttaatcacaacattcccaaagggccttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtgctttcagtgttctgttgatggtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcacaagaggatgaaataa
人PJVK蛋白异型体4(SEQ ID NO:57)(NCBI登录号NP_001340706.1)
MESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDLCVTSVSKGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK
人PJVK异型体4cDNA(SEQ ID NO:58)
atggagagcatccgaaccacacgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgcggtttcactttatggatgaacagaatcccaagggaagggacaaagctattgttttcccagcacatacaaccatagctttcagtgtttttgaactcttcatatacctggatggtgcctttgacctttgtgtcacttcagtgtcaaaaggaggatttgaaagggaagaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttgaaagaaatagaagagtgatggatgtcatttctcgttcacagctttacttggatgatcttttttctgactactatgacaaacctctcagcatgactgatatttcactcaaagaagggacccatatccgagttaacttacttaatcacaacattcccaaagggccttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtgctttcagtgttctgttgatggtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcacaagaggatgaaataa
人PJVK蛋白异型体5(SEQ ID NO:59)(NCBI登录号NP_001340707.1)
MESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDLCVTSVSKGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK
人PJVK异型体5cDNA(SEQ ID NO:60)
atggagagcatccgaaccacacgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgcggtttcactttatggatgaacagaatcccaagggaagggacaaagctattgttttcccagcacatacaaccatagctttcagtgtttttgaactcttcatatacctggatggtgcctttgacctttgtgtcacttcagtgtcaaaaggaggatttgaaagggaagaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttgaaagaaatagaagagtgatggatgtcatttctcgttcacagctttacttggatgatcttttttctgactactatgacaaacctctcagcatgactgatatttcactcaaagaagggacccatatccgagttaacttacttaatcacaacattcccaaagggccttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtgctttcagtgttctgttgatggtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcacaagaggatgaaataa
人PJVK蛋白异型体6(SEQ ID NO:61)(NCBI登录号NP_001356841.1)
MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKDILLGDREISAGISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVTKHEVEVSTLLKEITTRKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDLCVTSVSKGGFEREETATFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK
人PJVK异型体6cDNA(SEQ ID NO:62)
atgtttgctgctgctaccaagagctttgtcaagcaagttggagatggagggagattagttcctgttccaagcctcagtgaagctgacaaatatcaacctctaagtctggtggtaaaaaagaagcgatgctttctgtttcctagatataaatttacttcaacaccttttacactgaaagatattctcctaggagacagagaaatttcagctggtatttcatcttatcaattactgaattatgaagatgaatcagatgtttcactctatggaaggcgaggtaaccatattgtaaatgacgttgggattaacgttgctggatcagattccattgcagtgaaagcttcatttggtatagtaaccaaacatgaagtggaagtatcaacattactcaaagaaattactacacgaaaaattaactttgaccacagcttgatacgtcagtcaaggagcagcagaaaggcagtattgtgtgtggtcatggagagcatccgaaccacacgacagtgctcactgtctgtgcatgctggaattcgaggggaagcaatgcggtttcactttatggatgaacagaatcccaagggaagggacaaagctattgttttcccagcacatacaaccatagctttcagtgtttttgaactcttcatatacctggatggtgcctttgacctttgtgtcacttcagtgtcaaaaggaggatttgaaagggaagaaacggcaacatttgcactgctgtacaggttgagaaatatcctatttgaaagaaatagaagagtgatggatgtcatttctcgttcacagctttacttggatgatcttttttctgactactatgacaaacctctcagcatgactgatatttcactcaaagaagggacccatatccgagttaacttacttaatcacaacattcccaaagggccttgcatactctgtggaatggggaacttcaaaagggagacagtttatgggtgctttcagtgttctgttgatggtcagaagtatgtgagacttcatgcagttccttgttttgatatttggcacaagaggatgaaataa
在本文所述的任何组合物的一些实施方案中，PJVK蛋白包含与SEQ ID NO:51具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，PJVK蛋白包含与SEQ ID NO:53具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，PJVK蛋白包含与SEQ ID NO:55具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，PJVK蛋白包含与SEQ ID NO:57具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，PJVK蛋白包含与SEQ ID NO:59具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，PJVK蛋白包含与SEQ ID NO:61具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
人野生型PJVK基因组DNA序列的非限制性实例是SEQ ID NO:63。SEQ ID NO:63中的外显子是：核苷酸位置5001-5334(外显子1)、核苷酸位置6953-7185(外显子2)和核苷酸位置7897-8092(外显子3)、核苷酸位置8281-9208(外显子4)、核苷酸位置9575-9716(外显子5)、核苷酸位置12075-12192(外显子6)、核苷酸位置13913-14011(外显子7)和核苷酸位置14547-15131(外显子8)。SEQ ID NO:63中的内含子是：核苷酸位置1-5000(内含子1)、核苷酸位置5335-6952(内含子2)、核苷酸位置7186-7896(内含子3)；核苷酸位置8093-8280(内含子4)、核苷酸位置9209-9574(内含子5)、核苷酸位置9717-12074(内含子6)、核苷酸位置12193-13912(内含子7)和核苷酸位置14012-14546(内含子8)。
人PJVK基因序列(SEQ ID NO:63)(NCBI参考序列：NG_012186.1)
1 tttcttgccg ggagagaggg attagaggga ttgtccggcg tgggtctagg gtcgttgagg
61 cctaaagtta agcctttgtg gggaggacgg attgggggct gggtcacttt aagaaaaaga
121 ttctaaaatt acgaaggcag aattccaggg agtctcccgg gcctggtcctgaagcttgag
181 accccggata tatacgctcc agggggctgc ggtgcgctct tcgggtccccgagccctgtg
241 tttaggaaca cgcggggacg tccaaacacc cgctcctctc ccgccgggcgggctcctttg
301 tcttctgggc tttcgtcgcg agatggaacg ctgggtcagt gcatcccagcaaaacacgtt
361 aggagtaaac gaaggccttt ccggggacct gggtagtcgg ttgtaatggcgtttgcctgg
421 gatgcagcac ctttggtggg ccattagatg acgtgtcgct tctccaggggcttgctaggc
481 actagcagaa atgctcccct gtgcttactc ggtgttatgg aagattgcttgcacaatgct
541 attcgtacga aaggatatta ttaaaagtga tttatgggcg ggcgcggtggctcacgcctg
601 taatcccagc actttaggag gccgaggctg gcggatcgcc tgaagtaagcagttcgagac
661 cagcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaattagccgggcgt
721 ggtggcatgc gcctgtaatc ccagctactc gggaggctaa agcaggagaatcgcttgaac
781 ccgggaggca aatgttgcag tgagccgaga tcgcgccact gcactccagcctgggcgaca
841 gagtcagact ccctctcaaa aaaaaaaaaa aaaaaaaaag cgatttgttgttttgttagc
901 atgtaagccc tggatgcttg aaacaagtga aagatgttca gaatctaatcaaattatatc
961 atctgatgct ttaattagag cctattctct cttcctctcc gtctatatatgtatgtatat
1021 agattactat ccatcactgt tttaatggat atcttattgg aagggctacatagtcagtat
1081 ttcacaatat atgaactccg cataacacct atggcaaaac atttcagcactcaggtaaaa
1141 ttcatttttt gccacaaaat tacttaaaaa caggccagaa ctttatatagctcttgttaa
1201 aggttaagta gctgggataa taatgaaaca aaaagatgca gcaggactccatttcaaaga
1261 gagagagtct gtgtgcccaa cttcagagta agaaaccact aggtaatagtttatatagtt
1321 acttatatgt aatgtggctt tattttttaa ataaagattt gcatataattgtttatatct
1381 gtgaatttat atttaatatt aaacacagtt ttgtaagcat ataagatggaaaatgaatga
1441 aatgctcaat caatgagctg tatgccatga ggattcaaaa cagcactttggtgttgccaa
1501 aattccggtg gtggacttgt gaaggaattc cctttggact aggtccactgtagattgtat
1561 ccgggactat cgttagtgcc taaattgcat tgcttcccac agcactatatgcttccctta
1621 aaattggccc attgccagtg gcaaatcact atctactgtg atccttatcatagacattgg
1681 tcatattttt acgttattag ttttctgtgt atattttagt gctatagcctgccattccaa
1741 gttaaacatg ctcttagcat atcattttac accgttgatc tataattcattacctgagca
1801 catgagcaga ggcagggaat tatacagtgg taaactactt ggtgaaaccatgctttgtat
1861 ttttaagatg tataattata tttaaaaaca agcaatgctt aattttgtgcctgattttcc
1921 tctttaaaaa tggatttatc tgggggttgc agttgatgac gttttgattttaatatgttt
1981 gctgctgcta ccaagagctt tgtcaagcaa gttggagatg gagggagattagttcctgtt
2041 ccaagcctca gtgaagctga caaatatcaa cctctaagtc tggtggtaaaaaagaagcga
2101 tgctttctgt ttcctagata taaatttact tcaacacctt ttacactgaaagatattctc
2161 ctaggagaca gagaaatttc agctggtaag tttaaatgtt tgggagtgccaactcattca
2221 tctgtattat tggcaaccta aacataggtc atatatgcta cttatgttagtaatacacat
2281 tttcaatgat taaagcaact tttattatga tgttagtgta ataacattattaagattaac
2341 aatgccaaaa gtttgtataa tatcaaatct cttattggtc aaataattttcaaatctatc
2401 aattatttta taaattgttt taaccaaatc aacttagaat atgacatatttcttcatcta
2461 taaaatggga tattatttgg gcttacctat gttacatggt caaatgagatgaaaataatt
2521 tgtatttatt ttttacaatt caattattac aattggtaaa ctgaaatgtattgaagggta
2581 ggttatataa taagctgata ttttgatgag ttactactta taaacgcttattttttcttt
2641 taattgcccg gtggatcttg atgcttaaga agttctgttg gctgaatagaaaatttgagt
2701 tccttttaag aattctggct atgtgtttct ttttgttgta agattaattgaattactact
2761 ttaagtcttg gtgagtcatg ttgcctttct ctaacatttg ggtatttgagtcttcaattg
2821 ttaatttaac atgttactat atataatcta cataagataa agatgtttaaaaaatactga
2881 gtttcttctt ataaaggtat ttcatcttat caattactga attatgaagatgaatcagat
2941 gtttcactct atggaaggcg aggtaaccat attgtaaatg acgttgggattaacgttgct
3001 ggatcagatt ccattgcagt gaaagcttca tttggtatag taaccaaacatgaagtggaa
3061 gtatcaacat tactcaaaga aattactaca cggtcagtat aataatcctaatatatttca
3121 gtgttttcat taaatacttt aggtatataa acttcattac aaagaatgcttaaaacattg
3181 aggttgtatt ttactagtgt aatttgctag atatgtttga aatacattggtagtatatcc
3241 aaactttgaa taaggataga tatcaaaaat cacttggctg aagtcagagacctcagggcc
3301 ccagatcaag gagctaactg atgaagaggc agagaggctg cagctagagattgaccagaa
3361 ataggatgca gagaatcatg aggcccagat caagaatggc agccttgactccccagggaa
3421 gcagaagact gaggaagatg aggaggagga agatgagaag gacaaaggaaaactgaagcc
3481 caacctaggc aacagggcag acctgcctga ttaccgctgg accaagaccctgtcggagct
3541 ggacctggcg gtccctttct gtgtggactt ccagctgaaa gggaaggacgtggtggtggc
3601 atccaacggc ggcacctcca ggtggggctc aaggggcagc cagcgatcatcgatggggag
3661 ctctacaacg aagtgaaggc ggaggagagc tcgtggctca ttgaggacggcaaggtggtg
3721 actgtgcatc tggagaagat caagaagatg gagtggtgga gccgcttggtgtccagtgac
3781 cctgagatca ataccaagaa gattaaccct gagaattcca agctgtcagacctggacagt
3841 gagactcaca tcatggtgga aaagacaatc tatgaccagt aacagaagtccatggggctg
3901 ccaacctcag acgaacagaa gaaacaggag attctgaaga agttcatggatcagcatccg
3961 gagatggatt tttccaaggc taaattcaac tagcccctgt ttttccctccctgaactctt
4021 ggggctgagc tgcaaccacc caactttctt tcccactctt ctctgggacttgtgggcctc
4081 agggcttggg gcaggcatgg gactggccca ggcacacagg tcccagggcatcaggagaaa
4141 ggctggggct tggggtcttg tcctccccag ttggcctact gttacacattaaaatgattt
4201 gcccagctaa aaaaaaaaaa aaaccacttg gcttaaacaa aacttttaattgttccacaa
4261 aattactttg gctctacaca catttgctta attattagat ttaaataatacagcaatctg
4321 tctgcaacaa atagagtccc cttcaacaga ctttcaacag acagagtgaaacattctgca
4381 taagcatgtt ttaagaaaat agagaggaga gacaaattat tacatttcttttgggtgtat
4441 tttctgacta ttaggattgc cttgatttac tattaggtga actatgaatgaataacacat
4501 gatagcaaaa aatgtatttg attatgtgta attagatgtt atagagtcttgtgaatgtat
4561 cttctttatt ttagaaaaat taactttgac cacagcttga tacgtcagtcaaggagcagc
4621 agaaaggcag tattgtgtgt ggtcatggag agcatccgaa ccacacgacagtgctcactg
4681 tctgtgcatg ctggaattcg aggggaagca atgcgggtaa accacacttgttgggttctc
4741 ttactaacta aagtgttgcc atgggaattt ttttaagtat tgaatttctagtcaggcttg
4801 tgtattttgt gaaatgttct gatgaaagag ctgcagttgt ataggattttgcacagcaat
4861 gtctgttcta gaatatgaaa aaaaaaaaca aatcttggga ttctaaacatgtgtaatata
4921 atgcaaaaac agtaatcctt gtgaaattac gtgcatactg gagtccctcaagttactatt
4981 taagtgttgt tttaagaata aaaattgagt gagttgaatt gattttatttttaagtgata
5041 cagtttttga ctgggcacag tggctcacgc ctgtaatcct agcattttgggaggccgagg
5101 tgggcggatc acttgcagtc aggagttgga gatcaagttg ggcaacacagagaaacccca
5161 tctctactga aaatacaaaa attagccagg tgtggtggta cacccctgtaatcccaagcc
5221 actcaggaag ctgaggcaca agaatcactt gaacctggga ggtggaggttgcagtgagcc
5281 gagattgtgc cattgcactc taacctgggt ggcagagtga gactccgtctcaaaaaaaca
5341 aaacaaaaca aaaaccccaa ccaaaaaaaa aatgtgtaac ataatgcaaaaacagtaatc
5401 cttgtgaaat tacatgcata ctggagtccc tcatattact atttaagtgctgttttaaga
5461 ataaaaattg agtgcttaag ttgaattgat ttaagtgata gagtttttacactttgaatt
5521 ttttaaagct gaatttatag attttttttt tgagacggag tctcgctctgtccccgaggc
5581 tggagtgcag tggcgcgatc ttggctcact gcaaactccg cctcccgggttcatgccatt
5641 cttctgcctc agcctcccga gtagctggga ctacaggcac ctgccaccacgcccggcagt
5701 gttatccagg atggtttcga tctcctgacc tcgtgatccg ctagcctcggcctcccaaaa
5761 tgctgggatt acaggtgtga gccaccgcgc ctggcctgaa tttatatttttatattcaaa
5821 tagtttttca aagttaatat tatcaatggc catacatgct ttattcaaggttagttaaat
5881 cctttaaaaa atattagcgg caaggtgcag tggatcatgc ctgtaatcccagtgcttagg
5941 aagactgaga taggaagaca gcttgggacc aggagttcaa gaccaacttgagcaaaataa
6001 tgagaccttg tctctacaaa aaataaaaga attagctggt tgtggtggcacatgcctata
6061 gtcccagcta ctcggaaggc tgaggcaggg ggctgcctgc ggggtttgggtcattgtctt
6121 ttagaatttg ggaggctttg aaaagccgtg cttttgtgct ggggaagatgtagcagtctc
6181 ttctccaaac cacccatttg ccttcggact tctctggggc cagcagccatccaactaggg
6241 gcccggggcc acgggctcag ctgacgacca tgggcttcgc gtccaaccagcagtttgcag
6301 gttcgagctc aggacttggc ggggacacct taggatgcag gagtggccaggagttcaagg
6361 ttacagtagg ctatgattgt gccactgctc tccagcctgg gtgacagagagagaccctgt
6421 ctctgaaaaa aaaattggaa aagtatctgt gtttaatttt cagctcaattatgatattgt
6481 ttatctttgt cattcagtga cacctaataa tgacttgatt ggattaaaaccaattgttag
6541 aaagataggg ttcaaggata atcttttcaa gtctttgcaa ataaaagttattttcgcata
6601 ttcagctgcc tgtcaaattc tgattaacat tggatcattt ttgaggcacaaactgaaaca
6661 tttacttgat tgttagcgat tgctttagaa agctactaaa agctctggagggctttggaa
6721 tggtagacag gctaggctga aaactttaac tctggcactg ctttctaagatttcctgtta
6781 aaaaaaaaaa aaaggcttct gctccagagc attatggttg tggtagcactaatcatgggc
6841 tgtaatacca aagtaagtga aaagtgcaga ggtatttcct aatatagaccaggagtttct
6901 gttggaccaa ttggatctct gctataaaaa atggtttaat tcaagcagaataatccttta
6961 cttgggaatt ttttgttttg tttttggtag gattatagga aatgtttcatttctccaaaa
7021 agctatcctt acatgttatg atccttaatt atgttattta tttattcaatatagtttcac
7081 tttatggatg aacagaatcc caagggaagg gacaaagcta ttgttttcccagcacataca
7141 accatagctt tcagtgtttt tgaactcttc atatacctgg atggtgcctttggtgagtta
7201 agggtctgca tgaaatacaa atgattatat ttttaaggag cattcattagggcatgtgct
7261 ctctctctct cttttctctc atttctcgtg tctaacaatt atagaagatgctctcagcac
7321 tgtcaatctt atgctttggc aaaatagctg agaaagaccc tccgttcgctgcttccccat
7381 tccacttttc tgcttcttgg tgaaggttgt aaactctcca ctaccccatttaaaattata
7441 aataagagct aaaatgccat ctactgacaa agtattcctt agcttacatggggagataat
7501 aaatgacctt cttataggta gtttttgatg gtggcaaaca gaggagtaggtagatagtag
7561 gatgcctgaa gtgttaggat gcccaaacca gggcctctaa agacagcttttcttacttca
7621 gttttactta tcatagaccc agcttcccct tgcactcttc ctaaaaaataactttaaaaa
7681 gtgaaaatac ttcctccaaa attgtcacct tgtataatac ctaagtgcagctcactttag
7741 gtctctacat ttcacaggtc tttaaggtct gttggccaac tggaacaagtccaggtgtag
7801 cccaagggat caggaaaggc agcccctagc catggtaatt tacaaatgtttttagacctg
7861 ttcttgttca tttctgcaat tttgtaggag gagggaatag ggagtccagaaacaaaacaa
7921 aactacatgt taagtaaatt gtctttttaa aaaatatttt taatttttgtggctatatag
7981 tagattatat atatatttat gtatgggata catgaggtat tttgatacgggcatacagtg
8041 cataataatc acatcatgga aaatggggta tccatcccct caagcatttatcctttgtgt
8101 tacaaacaat ccaattatac tcttttagtt atttaaaaat gtacaaattctcagtctaag
8161 atggagaaaa aactgtacaa ttacattatt ttgactgtag tcaccctattatgcttccaa
8221 atactaggtc ttattaagta aattctaatt ggataacttt aggtttttacagttttattg
8281 atggttggga ggaatgtaaa tggactgata tatccacaag aatttaaaatatatatataa
8341 tttggacttc cacttctagg aatttatcct acagatatat ttacacatatatgaaatgat
8401 atgagtgcaa gtatattcag tcctcaataa caagagattg gaaacaacattaaggagact
8461 aaataatggt gcatccttgc aagagaatac tatgaagcca ataagaatataatactttta
8521 atagatattt ttcaagagct gagtataata tgtaactatt tgggcataaataattttata
8581 cacatacatg tatatatgca tctttcttta tgcttataaa atatatggagtatttctgga
8641 agcaaacata agaaacttaa accacgggtg cccctaagcc cctgaggtagaagactgtgg
8701 ctggatacag ggtgggccag agacctattt gtcactgtat ctcctttctgtatgaatttt
8761 gtaccatgtg aatgttacct tttccaaaag tatgtaaaag tcaacttttaaaaacaatac
8821 aatgaatgat ttgtactaga attcatcacc ccatcaaaca ataaaatatgaattattcaa
8881 gttataacat cttctaacaa ttttttttgt agacctttgt gtcacttcagtgtcaaaagg
8941 aggatttgaa agggaagaaa cggcaacatt tgcactgctg tacaggttgagaaatatcct
9001 atttgaaaga agtatgttta ttgaagagta ctgtgaatgt cttttttttttctttcctgg
9061 cttaacacat gaggttttct attcagtaat ctcatctgtt aaggaaaaatttaaatttaa
9121 aagcctggct ggtatggtgg ctcatgccta taatcccagc actttgggaggccagggcag
9181 gcagattgct agcactcaga agtttgaaac acttgggcaa tgtgagaaaaccccatctgt
9241 acaaagaata caaaagaaaa aaaattagtt ggttgcagtg gtgtgcacctgtagtcccag
9301 ctacttgaga ggctgaggta ggaggatcac ttgagcgtgg gaggcggaggttgtagtaag
9361 tggagattgt gccactgccc tccagcttgg gtgacagagc cagaccctgtctcaaaaaaa
9421 aaaaaaaaaa aaaaaaagcc aaattatttc atgactagtg gattcacatatttattaatg
9481 ctgtttgcat tatgtatttt tcattttcac ttctaacaca tttcttttctgtttttgtcc
9541 ttttagatag aagagtgatg gatgtcattt ctcgttcaca gctttacttggatgatcttt
9601 tttctgacta ctatgacaaa cctctcagca tgactgatat ttcactcaaagaagggaccc
9661 atatccgagt taacttactt aatcacaaca ttcccaaagg gccttgcatactctgtggaa
9721 tggggaactt caaaagggag acagtttatg ggtgctttca gtgttctgttgatggtcaga
9781 agtatgtgag acttcatgca gttccttgtt ttgatatttg gcacaagaggatgaaataaa
9841 atgaaaaatg aatacaccgt gttggtgttt taggtgcagt tgtgccacaaaccttcccta
9901 aattatctag gtttgctttg atgaattaaa ttaaaatgag aaaagcaaaaagaaattaac
9961 ctgtctgggt atcatattcc ctatctataa agtagcaatt ataacagtagtgtctatttc
10021 ttaagttgtc atgaaaatta ataacattgt ttatatcaaa aaagatttacatataaaatt
10081 cagagattat gaatcatgcc agtcacttta gaatcatttt tgggatgtag t
热休克蛋白家族A(Hsp70)成员1A(HSPA1A)
HSPA1A基因编码“热激蛋白家族A成员1A”(HSPA1A)。人HSPA1A基因位于染色体6p21.33上。其包含1个外显子，涵盖约2400bp(NCBI登录号NC_000006.12)。HSPA1A编码70kDa的热激蛋白，所述蛋白可稳定蛋白质使其免于蛋白质聚集，并参与蛋白质折叠。
示例性野生型HSPA1A蛋白序列为或包括SEQ ID NO:64、SEQ ID NO:66、SEQ IDNO:68、SEQ ID NO:69、SEQ ID NO:70和SEQ ID NO:93。编码NDP蛋白的示例性DNA序列如下所示。
人成熟HSPA1A蛋白(SEQ ID NO:64)(NCBI登录号NP_005336.3)
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
人成熟HSPA1A cDNA(SEQ ID NO:65)
atggccaaagccgcggcgatcggcatcgacctgggcaccacctactcctgcgtgggggtgttccaacacggcaaggtggagatcatcgccaacgaccagggcaaccgcaccacccccagctacgtggccttcacggacaccgagcggctcatcggggatgcggccaagaaccaggtggcgctgaacccgcagaacaccgtgtttgacgcgaagcggctgatcggccgcaagttcggcgacccggtggtgcagtcggacatgaagcactggcctttccaggtgatcaacgacggagacaagcccaaggtgcaggtgagctacaagggggagaccaaggcattctaccccgaggagatctcgtccatggtgctgaccaagatgaaggagatcgccgaggcgtacctgggctacccggtgaccaacgcggtgatcaccgtgccggcctacttcaacgactcgcagcgccaggccaccaaggatgcgggtgtgatcgcggggctcaacgtgctgcggatcatcaacgagcccacggccgccgccatcgcctacggcctggacagaacgggcaagggggagcgcaacgtgctcatctttgacctgggcgggggcaccttcgacgtgtccatcctgacgatcgacgacggcatcttcgaggtgaaggccacggccggggacacccacctgggtggggaggactttgacaacaggctggtgaaccacttcgtggaggagttcaagagaaaacacaagaaggacatcagccagaacaagcgagccgtgaggcggctgcgcaccgcctgcgagagggccaagaggaccctgtcgtccagcacccaggccagcctggagatcgactccctgtttgagggcatcgacttctacacgtccatcaccagggcgaggttcgaggagctgtgctccgacctgttccgaagcaccctggagcccgtggagaaggctctgcgcgacgccaagctggacaaggcccagattcacgacctggtcctggtcgggggctccacccgcatccccaaggtgcagaagctgctgcaggacttcttcaacgggcgcgacctgaacaagagcatcaaccccgacgaggctgtggcctacggggcggcggtgcaggcggccatcctgatgggggacaagtccgagaacgtgcaggacctgctgctgctggacgtggctcccctgtcgctggggctggagacggccggaggcgtgatgactgccctgatcaagcgcaactccaccatccccaccaagcagacgcagatcttcaccacctactccgacaaccaacccggggtgctgatccaggtgtacgagggcgagagggccatgacgaaagacaacaatctgttggggcgcttcgagctgagcggcatccctccggcccccaggggcgtgccccagatcgaggtgaccttcgacatcgatgccaacggcatcctgaacgtcacggccacggacaagagcaccggcaaggccaacaagatcaccatcaccaacgacaagggccgcctgagcaaggaggagatcgagcgcatggtgcaggaggcggagaagtacaaagcggaggacgaggtgcagcgcgagagggtgtcagccaagaacgccctggagtcctacgccttcaacatgaagagcgccgtggaggatgaggggctcaagggcaagatcagcgaggcggacaagaagaaggttctggacaagtgtcaagaggtcatctcgtggctggacgccaacaccttggccgagaaggacgagtttgagcacaagaggaaggagctggagcaggtgtgtaaccccatcatcagcggactgtaccagggtgccggtggtcccgggcctgggggcttcggggctcagggtcccaagggagggtctgggtcaggccccaccattgaggaggtggattag
人成熟HSPA1A cDNA(SEQ ID NO:94)
atgtaccggatgcagctgctgagctgtatcgccctgtctctggccctggtcaccaattctgccaaagccgcggcgatcggcatcgacctgggcaccacctactcctgcgtgggggtgttccaacacggcaaggtggagatcatcgccaacgaccagggcaaccgcaccacccccagctacgtggccttcacggacaccgagcggctcatcggggatgcggccaagaaccaggtggcgctgaacccgcagaacaccgtgtttgacgcgaagcggctgatcggccgcaagttcggcgacccggtggtgcagtcggacatgaagcactggcctttccaggtgatcaacgacggagacaagcccaaggtgcaggtgagctacaagggggagaccaaggcattctaccccgaggagatctcgtccatggtgctgaccaagatgaaggagatcgccgaggcgtacctgggctacccggtgaccaacgcggtgatcaccgtgccggcctacttcaacgactcgcagcgccaggccaccaaggatgcgggtgtgatcgcggggctcaacgtgctgcggatcatcaacgagcccacggccgccgccatcgcctacggcctggacagaacgggcaagggggagcgcaacgtgctcatctttgacctgggcgggggcaccttcgacgtgtccatcctgacgatcgacgacggcatcttcgaggtgaaggccacggccggggacacccacctgggtggggaggactttgacaacaggctggtgaaccacttcgtggaggagttcaagagaaaacacaagaaggacatcagccagaacaagcgagccgtgaggcggctgcgcaccgcctgcgagagggccaagaggaccctgtcgtccagcacccaggccagcctggagatcgactccctgtttgagggcatcgacttctacacgtccatcaccagggcgaggttcgaggagctgtgctccgacctgttccgaagcaccctggagcccgtggagaaggctctgcgcgacgccaagctggacaaggcccagattcacgacctggtcctggtcgggggctccacccgcatccccaaggtgcagaagctgctgcaggacttcttcaacgggcgcgacctgaacaagagcatcaaccccgacgaggctgtggcctacggggcggcggtgcaggcggccatcctgatgggggacaagtccgagaacgtgcaggacctgctgctgctggacgtggctcccctgtcgctggggctggagacggccggaggcgtgatgactgccctgatcaagcgcaactccaccatccccaccaagcagacgcagatcttcaccacctactccgacaaccaacccggggtgctgatccaggtgtacgagggcgagagggccatgacgaaagacaacaatctgttggggcgcttcgagctgagcggcatccctccggcccccaggggcgtgccccagatcgaggtgaccttcgacatcgatgccaacggcatcctgaacgtcacggccacggacaagagcaccggcaaggccaacaagatcaccatcaccaacgacaagggccgcctgagcaaggaggagatcgagcgcatggtgcaggaggcggagaagtacaaagcggaggacgaggtgcagcgcgagagggtgtcagccaagaacgccctggagtcctacgccttcaacatgaagagcgccgtggaggatgaggggctcaagggcaagatcagcgaggcggacaagaagaaggttctggacaagtgtcaagaggtcatctcgtggctggacgccaacaccttggccgagaaggacgagtttgagcacaagaggaaggagctggagcaggtgtgtaaccccatcatcagcggactgtaccagggtgccggtggtcccgggcctgggggcttcggggctcagggtcccaagggagggtctgggtcaggccccaccattgaggaggtggattaa
在本文所述的任何组合物的一些实施方案中，所述HSPA1A蛋白包含与SEQ IDNO:64具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，所述HSPA1A蛋白包含与SEQ IDNO:66具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，所述HSPA1A蛋白包含与SEQ IDNO:68具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，所述HSPA1A蛋白包含与SEQ IDNO:69具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，所述HSPA1A蛋白包含与SEQ IDNO:70具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，所述HSPA1A蛋白包含与SEQ IDNO:94具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
小鼠成熟的HSPA1A蛋白(SEQ ID NO:66)(NCBI登录号NP_034609.2)
MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKMKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPKGASGSGPTIEEVD
小鼠成熟HSPA1A cDNA(SEQ ID NO:67)
atggccaag aacacggcga tcggcatcga cctgggcacc acctactcgt gcgtgggcgtgttccagcac ggcaaggtgg agatcatcgc caacgaccag ggcaaccgca cgacccccag ctacgtggccttcaccgaca ccgagcgcct catcggagac gccgccaaga accaggtggc gctgaacccg cagaacaccgtgttcgacgc gaagcggctg atcggccgca agttcggcga tgcggtggtg cagtccgaca tgaagcactggcccttccag gtggtgaacg acggcgacaa gcccaaggtg caggtgaact acaagggcga gagccggtcgttcttcccgg aggagatctc gtccatggtg ctgacgaaga tgaaggagat cgctgaggcg tacctgggccacccggtgac caacgcggtg atcacggtgc ccgcctactt caacgactct cagcggcagg ccaccaaggacgcgggcgtg atcgccggtc taaacgtgct gcggatcatc aacgagccca cggcggccgc catcgcctacgggctggacc ggaccggcaa gggcgagcgc aacgtgctca tcttcgacct ggggggcggc acgttcgacgtgtccatcct gacgatcgac gacggcatct tcgaggtgaa ggccacggcg ggcgacacgc acctgggaggggaggacttc gacaaccggc tggtgagcca cttcgtggag gagttcaaga ggaagcacaa gaaggacatcagccagaaca agcgcgcggt gcggcggctg cgcactgcgt gtgagagggc caagaggacg ctgtcgtccagcacccaggc cagcctggag atcgactctc tgttcgaggg catcgacttc tacacatcca tcacgcgggcgcggttcgaa gagctgtgct cagacctgtt ccgcggcacg ctggagcccg tggagaaggc cctgcgcgacgccaagatgg acaaggcgca gatccacgac ctggtgctgg tgggcggctc gacgcgcatc cccaaggtgcagaagctgct gcaggacttc ttcaacgggc gcgacctgaa caagagcatc aacccggacg aggcggtggcctacggggcg gcggtgcagg cggccatcct gatgggggac aagtcggaga acgtgcagga cctgctgctgctggacgtgg cgccgctgtc gctgggcctg gagactgcgg gcggcgtgat gacggcgctc atcaagcgcaactccaccat ccccaccaag cagacgcaga ccttcaccac ctactcggac aaccagcccg gggtgctgatccaggtgtac gagggcgaga gggccatgac gcgcgacaac aacctgctgg ggcgcttcga actgagcggcatcccgccgg cgcccagggg cgtgccacag atcgaggtga ccttcgacat cgacgccaac ggcatcctgaacgtcacggc caccgacaag agcaccggca aggccaacaa gatcaccatc accaacgaca agggccgcctgagcaaggag gagatcgagc gcatggtgca ggaggccgag cgctacaagg ccgaggacga ggtgcagcgcgacagggtgg ccgccaagaa cgcgctcgaa tcctatgcct tcaacatgaa gagcgccgtg gaggacgagggtctcaaggg caagctcagc gaggctgaca agaagaaggt gctggacaag tgccaggagg tcatctcctggctggactcc aacacgctgg ccgacaagga ggagttcgtg cacaagcggg aggagctgga gcgggtgtgcagccccatca tcagtgggct gtaccagggt gcgggtgctc ctggggctgg gggcttcggg gcccaggcgcccaagggagc ctctggctca ggacccacca tcgaggaggt ggattaga
恒河猴成熟HSPA1A蛋白(SEQ ID NO:68)(NCBI登录号XP_014991489.2)
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
大鼠成熟HSPA1A蛋白(SEQ ID NO:69)(NCBI登录号NP_114177.2)
MAKKTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVVNDGDKPKVQVNYKGENRSFYPEEISSMVLTKMKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRERVAAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDSNTLAEKEEFVHKREELERVCNPIISGLYQGAGAPGAGGFGAQAPKGGSGSGPTIEEVD
牛HSPA1A蛋白(SEQ ID NO:70)(NCBI登录号NP_976067.3)
MAKNMAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFRVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISRLYQGAGGPGAGGFGAQGPKGGSGSGPTIEEVD
人成熟HSPA1A蛋白(SEQ ID NO:93)
AKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
人野生型NDP基因组DNA序列的非限制性实例是SEQ ID NO:71。
人HSPA1A基因序列(SEQ ID NO:71)(NCBI参考序列NC_000006.12)
1 aacggctagc ctgaggagct gctgcgacag tccactacct ttttcgagag tgactcccgt61 tgtcccaagg cttcccagag cgaacctgtg cggctgcagg caccggcgcg tcgagtttcc 121ggcgtccgga aggaccgagc tcttctcgcg gatccagtgt tccgtttcca gcccccaatc 181tcagagcgga gccgacagag agcagggaac cggcatggcc aaagccgcgg cgatcggcat 241cgacctgggc accacctact cctgcgtggg ggtgttccaa cacggcaagg tggagatcat 301cgccaacgac cagggcaacc gcaccacccc cagctacgtg gccttcacgg acaccgagcg 361gctcatcggg gatgcggcca agaaccaggt ggcgctgaac ccgcagaaca ccgtgtttga 421cgcgaagcgg ctgattggcc gcaagttcgg cgacccggtg gtgcagtcgg acatgaagca 481ctggcctttc caggtgatca acgacggaga caagcccaag gtgcaggtga gctacaaggg 541ggagaccaag gcattctacc ccgaggagat ctcgtccatg gtgctgacca agatgaagga 601gatcgccgag gcgtacctgg gctacccggt gaccaacgcg gtgatcaccg tgccggccta 661cttcaacgac tcgcagcgcc aggccaccaa ggatgcgggt gtgatcgcgg ggctcaacgt 721gctgcggatc atcaacgagc ccacggccgc cgccatcgcc tacggcctgg acagaacggg 781caagggggag cgcaacgtgc tcatctttga cctgggcggg ggcaccttcg acgtgtccat 841cctgacgatc gacgacggca tcttcgaggt gaaggccacg gccggggaca cccacctggg 901tggggaggac tttgacaaca ggctggtgaa ccacttcgtg gaggagttca agagaaaaca 961caagaaggac atcagccaga acaagcgagc cgtgaggcgg ctgcgcaccg cctgcgagag 1021ggccaagagg accctgtcgt ccagcaccca ggccagcctg gagatcgact ccctgtttga 1081gggcatcgac ttctacacgt ccatcaccag ggcgaggttc gaggagctgt gctccgacct 1141gttccgaagc accctggagc ccgtggagaa ggctctgcgc gacgccaagc tggacaaggc 1201ccagattcac gacctggtcc tggtcggggg ctccacccgc atccccaagg tgcagaagct 1261gctgcaggac ttcttcaacg ggcgcgacct gaacaagagc atcaaccccg acgaggctgt 1321ggcctacggg gcggcggtgc aggcggccat cctgatgggg gacaagtccg agaacgtgca 1381ggacctgctg ctgctggacg tggctcccct gtcgctgggg ctggagacgg ccggaggcgt 1441gatgactgcc ctgatcaagc gcaactccac catccccacc aagcagacgc agatcttcac 1501cacctactcc gacaaccaac ccggggtgct gatccaggtg tacgagggcg agagggccat 1561gacgaaagac aacaatctgt tggggcgctt cgagctgagc ggcatccctc cggcccccag 1621gggcgtgccc cagatcgagg tgaccttcga catcgatgcc aacggcatcc tgaacgtcac 1681ggccacggac aagagcaccg gcaaggccaa caagatcacc atcaccaacg acaagggccg 1741cctgagcaag gaggagatcg agcgcatggt gcaggaggcg gagaagtaca aagcggagga 1801cgaggtgcag cgcgagaggg tgtcagccaa gaacgccctg gagtcctacg ccttcaacat 1861gaagagcgcc gtggaggatg aggggctcaa gggcaagatc agcgaggcgg acaagaagaa 1921ggtgctggac aagtgtcaag aggtcatctc gtggctggac gccaacacct tggccgagaa 1981ggacgagttt gagcacaaga ggaaggagct ggagcaggtg tgtaacccca tcatcagcgg 2041actgtaccag ggtgccggtg gtcccgggcc tgggggcttc ggggctcagg gtcccaaggg 2101agggtctggg tcaggcccca ccattgagga ggtagattag gggcctttcc aagattgctg 2161tttttgtttt ggagcttcaa gactttgcat ttcctagtat ttctgtttgt cagttctcaa 2221tttcctgtgt ttgcaatgtt gaaatttttt ggtgaagtac tgaacttgct ttttttccgg 2281tttctacatg cagagatgaa tttatactgc catcttacga ctatttcttc tttttaatac 2341acttaactca ggccattttt taagttggtt acttcaaagt aaataaactt taaaattcaa
人HSPA1A基因序列(SEQ ID NO:94)
atgtaccggatgcagctgctgagctgtatcgccctgtctctggccctggtcaccaattctgccaaagccgcggcgatcggcatcgacctgggcaccacctactcctgcgtgggggtgttccaacacggcaaggtggagatcatcgccaacgaccagggcaaccgcaccacccccagctacgtggccttcacggacaccgagcggctcatcggggatgcggccaagaaccaggtggcgctgaacccgcagaacaccgtgtttgacgcgaagcggctgatcggccgcaagttcggcgacccggtggtgcagtcggacatgaagcactggcctttccaggtgatcaacgacggagacaagcccaaggtgcaggtgagctacaagggggagaccaaggcattctaccccgaggagatctcgtccatggtgctgaccaagatgaaggagatcgccgaggcgtacctgggctacccggtgaccaacgcggtgatcaccgtgccggcctacttcaacgactcgcagcgccaggccaccaaggatgcgggtgtgatcgcggggctcaacgtgctgcggatcatcaacgagcccacggccgccgccatcgcctacggcctggacagaacgggcaagggggagcgcaacgtgctcatctttgacctgggcgggggcaccttcgacgtgtccatcctgacgatcgacgacggcatcttcgaggtgaaggccacggccggggacacccacctgggtggggaggactttgacaacaggctggtgaaccacttcgtggaggagttcaagagaaaacacaagaaggacatcagccagaacaagcgagccgtgaggcggctgcgcaccgcctgcgagagggccaagaggaccctgtcgtccagcacccaggccagcctggagatcgactccctgtttgagggcatcgacttctacacgtccatcaccagggcgaggttcgaggagctgtgctccgacctgttccgaagcaccctggagcccgtggagaaggctctgcgcgacgccaagctggacaaggcccagattcacgacctggtcctggtcgggggctccacccgcatccccaaggtgcagaagctgctgcaggacttcttcaacgggcgcgacctgaacaagagcatcaaccccgacgaggctgtggcctacggggcggcggtgcaggcggccatcctgatgggggacaagtccgagaacgtgcaggacctgctgctgctggacgtggctcccctgtcgctggggctggagacggccggaggcgtgatgactgccctgatcaagcgcaactccaccatccccaccaagcagacgcagatcttcaccacctactccgacaaccaacccggggtgctgatccaggtgtacgagggcgagagggccatgacgaaagacaacaatctgttggggcgcttcgagctgagcggcatccctccggcccccaggggcgtgccccagatcgaggtgaccttcgacatcgatgccaacggcatcctgaacgtcacggccacggacaagagcaccggcaaggccaacaagatcaccatcaccaacgacaagggccgcctgagcaaggaggagatcgagcgcatggtgcaggaggcggagaagtacaaagcggaggacgaggtgcagcgcgagagggtgtcagccaagaacgccctggagtcctacgccttcaacatgaagagcgccgtggaggatgaggggctcaagggcaagatcagcgaggcggacaagaagaaggttctggacaagtgtcaagaggtcatctcgtggctggacgccaacaccttggccgagaaggacgagtttgagcacaagaggaaggagctggagcaggtgtgtaaccccatcatcagcggactgtaccagggtgccggtggtcccgggcctgggggcttcggggctcagggtcccaagggagggtctgggtcaggccccaccattgaggaggtggattaa
血管内皮生长因子(VEGF)
VEGF基因编码血管内皮生长因子(VEGF)，以前称为fms样酪氨酸激酶(Flt-1)。VEGF蛋白是诱导血管内皮细胞迁移和增殖的肝素抑制蛋白。
人VEGF基因位于染色体6p21上。其包含8个外显子，涵盖约16千碱基(kb)(NCBI登录号NG_008732.1)。从人VEGF基因表达的全长野生型VEGF蛋白的长度为412个氨基酸。
示例性人野生型VEGF蛋白为或包括SEQ ID NO:72、SEQ ID NO:74或SEQ ID NO:76、SEQ ID NO:77、SEQ ID NO:78或SEQ ID NO:79的序列。编码野生型VEGF蛋白的核酸的非限制性实例为或包括SEQ ID NO:73和SEQ ID NO:75。
下面示出编码野生型VEGF蛋白的蛋白质和核苷酸序列的非限制性实例。
人VEGF转录变体1蛋白质序列(SEQ ID NO:72)
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
人VEGF转录变体1cDNA(SEQ ID NO:73)
ctgacggacagacagacagacaccgcccccagccccagctaccacctcctccccggccggcggcggacagtggacgcggcggcgagccgcgggcaggggccggagcccgcgcccggaggcggggtggagggggtcggggctcgcggcgtcgcactgaaacttttcgtccaacttctgggctgttctcgcttcggaggagccgtggtccgcgcgggggaagccgagccgagcggagccgcgagaagtgctagctcgggccgggaggagccgcagccggaggagggggaggaggaagaagagaaggaagaggagagggggccgcagtggcgactcggcgctcggaagccgggctcatggacgggtgaggcggcggtgtgcgcagacagtgctccagccgcgcgcgctccccaggccctggcccgggcctcgggccggggaggaagagtagctcgccgaggcgccgaggagagcgggccgccccacagcccgagccggagagggagcgcgagccgcgccggccccggtcgggcctccgaaaccatgaactttctgctgtcttgggtgcattggagccttgccttgctgctctacctccaccatgccaagtggtcccaggctgcacccatggcagaaggaggagggcagaatcatcacgaagtggtgaagttcatggatgtctatcagcgcagctactgccatccaatcgagaccctggtggacatcttccaggagtaccctgatgagatcgagtacatcttcaagccatcctgtgtgcccctgatgcgatgcgggggctgctgcaatgacgagggcctggagtgtgtgcccactgaggagtccaacatcaccatgcagattatgcggatcaaacctcaccaaggccagcacataggagagatgagcttcctacagcacaacaaatgtgaatgcagaccaaagaaagatagagcaagacaagaaaaaaaatcagttcgaggaaagggaaaggggcaaaaacgaaagcgcaagaaatcccggtataagtcctggagcgtgtacgttggtgcccgctgctgtctaatgccctggagcctccctggcccccatccctgtgggccttgctcagagcggagaaagcatttgtttgtacaagatccgcagacgtgtaaatgttcctgcaaaaacacagactcgcgttgcaaggcgaggcagcttgagttaaacgaacgtacttgcagatgtgacaagccgaggcggtga
人VEGF转录变体3蛋白质序列(SEQ ID NO:74)
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
人VEGF转录变体3cDNA(SEQ ID NO:75)
ctgacggacagacagacagacaccgcccccagccccagctaccacctcctccccggccggcggcggacagtggacgcggcggcgagccgcgggcaggggccggagcccgcgcccggaggcggggtggagggggtcggggctcgcggcgtcgcactgaaacttttcgtccaacttctgggctgttctcgcttcggaggagccgtggtccgcgcgggggaagccgagccgagcggagccgcgagaagtgctagctcgggccgggaggagccgcagccggaggagggggaggaggaagaagagaaggaagaggagagggggccgcagtggcgactcggcgctcggaagccgggctcatggacgggtgaggcggcggtgtgcgcagacagtgctccagccgcgcgcgctccccaggccctggcccgggcctcgggccggggaggaagagtagctcgccgaggcgccgaggagagcgggccgccccacagcccgagccggagagggagcgcgagccgcgccggccccggtcgggcctccgaaaccatgaactttctgctgtcttgggtgcattggagccttgccttgctgctctacctccaccatgccaagtggtcccaggctgcacccatggcagaaggaggagggcagaatcatcacgaagtggtgaagttcatggatgtctatcagcgcagctactgccatccaatcgagaccctggtggacatcttccaggagtaccctgatgagatcgagtacatcttcaagccatcctgtgtgcccctgatgcgatgcgggggctgctgcaatgacgagggcctggagtgtgtgcccactgaggagtccaacatcaccatgcagattatgcggatcaaacctcaccaaggccagcacataggagagatgagcttcctacagcacaacaaatgtgaatgcagaccaaagaaagatagagcaagacaagaaaaaaaatcagttcgaggaaagggaaaggggcaaaaacgaaagcgcaagaaatcccgtccctgtgggccttgctcagagcggagaaagcatttgtttgtacaagatccgcagacgtgtaaatgttcctgcaaaaacacagactcgcgttgcaaggcgaggcagcttgagttaaacgaacgtacttgcagatgtgacaagccgaggcggtga
成熟人VEGF-A(SEQ ID NO:76)
APMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
成熟人VEGF-B(SEQ ID NO:77)
PVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPADITHPTPAPGPSAHAAPSTTSALTPGPAAAAADAAASSVAKGGA
成熟人VEGF-C(SEQ ID NO:78)
AHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRR
成熟人VEGF-D(SEQ ID NO:79)
FAATFYDIETLKVIDEEWQRTQCSPRETCVEVASELGKSTNTFFKPPCVNVFRCGGCCNEESLICMNTSTSYISKQLFEISVPLTSVPELVPVKVANHTGCKCLPTAPRHPYSIIRR
在本文所述的任何组合物的一些实施方案中，VEGF蛋白包含与SEQ ID NO:72具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，VEGF蛋白包含与SEQ ID NO:74具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，VEGF蛋白包含与SEQ ID NO:76具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，VEGF蛋白包含与SEQ ID NO:77具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，VEGF蛋白包含与SEQ ID NO:78具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
在本文所述的任何组合物的一些实施方案中，VEGF蛋白包含与SEQ ID NO:79具有至少75％(例如，至少80％、至少85％、至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％、至少99％)同一性的序列。
人野生型VEGF基因组DNA序列的非限制性实例是SEQ ID NO:80。SEQ ID NO:80中的外显子是：核苷酸位置1-1104(外显子1)、核苷酸位置4133-4184(外显子2)和核苷酸位置7261-7457(外显子3)、核苷酸位置8252-8328(外显子4)、核苷酸位置8681-8710(外显子5)、核苷酸位置10524-10646(外显子6)、核苷酸位置11748-11879(外显子7)和核苷酸位置14333-16279(外显子8)。SEQ ID NO:80中的内含子是：核苷酸位置1105-4132(内含子1)、核苷酸位置4185-7260(内含子2)、核苷酸位置7458-8251(内含子3)；核苷酸位置8329-8680(内含子4)、核苷酸位置8711-10523(内含子5)、核苷酸位置10647-11747(内含子6)和核苷酸位置11880-14332(内含子7)。
人VEGF-A基因(SEQ ID NO:80)(NCBI登录号NG_008732.1)
1 cgcctgtaat cccagcactc tgggaggcag aggtgggccg atcacttgag gtcaggagtt
61 cgagaccagc ctgggcaaca tggtgaaaca ccatctctac taaaaacaca aaaattagcc
121 aggtgtggtg gcaggcacct gcagtcccag ctactccgga ggctgaggcaggagaattgc
181 tcgaacctgg gaggcagggg ttgcagtgag ccgacatggc gccactgcactccagtctgg
241 gcgacagagt gagaccctat ctcaaaaaaa aaaaaaaaaa aaaaagacccaactcaagta
301 tcatctccag gaagccttcc cctactccca gcaattaaat gctcctcagagaattcccat
361 ttttggttta ctctttggtt tacctccaga caggaagccc ccactgacactgttgtagtc
421 ccagggtgca acacaaagca gagatcacaa gctgagttta ataattgcttgtggaataca
481 tgtcccaagc cacctcctgc aggaagccct tccagatgcc cattctagccagtctggctc
541 tttgcttcca taccttcaca acacttgtgc ctcccccagg gcctctttctcatcttgctt
601 tctggggcag ctgtgtgcac atttgtctgt gtgcagcaac tctctaaggcagggattttt
661 actcctattt ttgatgaggg gagctgtggc tcagagaggt tgaataacctaaggccacac
721 agtgagtggc agagccagga atgtgacttg ggtccatttg aatccaaagtccctgtactt
781 tccactgccc tacctagatg tccctgtacc tcctataaaa tcagcatggagcctggtgcc
841 tggtagtccc tacaaatatt cacaaattgg agcttagctc agctctcaggcaaggcccag
901 gtcaaaaggg cagatacagc tttgggacct tagttgccac cacatgccataccttcttcc
961 cagcagaagg actccctcca agacagggta ggggtggagg atgtgaacaggggcagaaat
1021 gggcatgttt tggggtcaga cttggaggaa tagcagagat tggagtgtcagaaggtgagc
1081 atgcctgggg gtgttgggga gatgcaattc atcagggaca gcttagtgtcaggggattag
1141 actggggccc atgaaggaga ggcagaggct gatgggccta ggggtggtgtgggtaggtga
1201 gcttccccag acagtgactc tgccctgccc tctctccagc taggtcctcttccccattcc
1261 ttcccccttt cctgactgga tcctcttggg agagttaccc tccttggcttcctctgctcc
1321 aatcttttta tcagttggcc atcattactt atcattacct caagtcaaacctccagatcc
1381 acatggggct aggacattgg cactggacca aagaggccct ttcctttgctttctctttgt
1441 ctttttaatg ctttgttgca aagacctagg cggggagaga gagagagagagagagacaga
1501 gattgaccca cagtcagggt cagggaattg aggggaacca acccaattctctctccttca
1561 attcaccagg tttgtatcct gcccttcctg cagatcagtg tcctgctagtcacctggggg
1621 tcaggggatg gagtgaagga caagacctcc ttccattgca gtgaagccacttggagaaat
1681 gtgtggaaaa cagcaagacc cagtgactct ctcctcacct tctttccaatctcaggagag
1741 attttgtccc ttcatccacc ggcttctaga ttaaccaccc acacccacacaggcgagagt
1801 ttccctgaat attggaggtg acaggacatc aggacaaagt acaactattgtgccttggcc
1861 caatcactac tttctttgtc tggggccgcc gctggctcct ggctgcctttcgcacttttc
1921 tccaccccca cccctttctc cccttccccc tcacctggaa caccttccccttcctccttg
1981 gctccttctg aactgccttc agagccacag actgtgggga gtggccactgcgctcccaag
2041 gtgaggccct ccaagcgggg ccgagtttgc ccctcaactg ggagccagcatgacctctgt
2101 gtgggctgct ctctgcttca ctgccccttc ccccaatctg ctaggtgaccctgggcccct
2161 ttgtgccctc tctgggcctt cggaggattc tttggggaga cagtctgctctgacgcccct
2221 tcccctgcag caagcagcct ggggagggag gtgaggataa gtgaagtcaagttgttcagg
2281 gggctaagcc catggaaggg aagatgccac agagatacat gtggtcttgtgattgttgtt
2341 ttgtgctttt tccccttttt tgaaagctca ggtgactagg tgacttgagcttttaatttg
2401 gtgacaatgt gggcactggc tgagtcctta agagtacatt gttgtaaatgccggtgacaa
2461 cacactgggg catgggatcc agagttaacc cctccaggtc acagccaggttatatctcca
2521 caatgaaggg gggaggtggg ccatactttc tcgccctaat gaaggtagctcaaaaacccc
2581 taggccaggt tgtaatccta gccttatata aaaggaattc tgtgccctcactcccctgga
2641 tccctgggca aagccccaga gggaaacaca aacaggttgt tgtaacacaccttgctgggt
2701 accaccatgg aggacagttg gcttatgggg gtggggggtg cctggggccacggagtgact
2761 ggtgatggct atccctcctt ggaacccctc cagcctcctc ttagcttcagatttgtttat
2821 ttgtttttta ctaagacctg ctctttcagg tctgttggct cttttaggggctgaagaagg
2881 ccgagttgag aagggatgca agggaggggg ccagaatgag cccttagggctcagagcctc
2941 catcctgccc caagatgtct acagcttgtg ctcctggggt gctagaggcgcacaaggagg
3001 aaagttagtg gcttcccttc catatcccgt tcatcagcct agagcatggagcccaggtga
3061 ggaggcctgc ctgggagggg gccctgagcc aggaaataaa catttactaactgtacaaag
3121 accttgtccc tgctgctggg gagcctgcca agtggtggag acaggactagtgcacgaatg
3181 atggaaaggg agggttgggg tgggtgggag ccagcccttt tcctcataagggccttagga
3241 caccataccg atggaactgg gggtactggg gaggtaacct agcacctccaccaaaccaca
3301 gcaacatgtg ctgaggatgg ggctgactag gtaagctccc tggagcgttttggttaaatt
3361 gagggaaatt gctgcattcc cattctcagt ccatgcctcc acagaggctatgccagctgt
3421 aggccagacc ctggcaagat ctgggtggat aatcagactg actggtcccactcttcccac
3481 aggcctcaga gccccaactt tgttccctgg ggcagcctgg aaatagccaggtcagaaacc
3541 agctaggaat ttttccaagc tgcttcctat atgcaagaat gggatggggcctttgggagc
3601 acttagggaa gatgtggaga gttggaggaa aagggggctt ggaggtaagggaggggactg
3661 ggggaaggat aggggagaag ctgtgagcct ggagaagtag ccaagggatcctgagggaat
3721 gggggagctg agacgaaacc cccatttcta ttcagaagat gagctatgagtctgggcttg
3781 ggctgataga agccttggcc cctggcctgg tgggagctct gggcagctggcctacagacg
3841 ttccttagtg ctggcgggta ggtttgaatc atcacgcagg ccctggcctccacccgcccc
3901 caccagcccc ctggcctcag ttccctggca acatctgggg ttgggggggcagcaggaaca
3961 agggcctctg tctgcccagc tgcctccccc tttgggtttt gccagactccacagtgcata
4021 cgtgggctcc aacaggtcct cttccctccc agtcactgac taaccccggaaccacacagc
4081 ttcccgttct cagctccaca aacttggtgc caaattcttc tcccctgggaagcatccctg
4141 gacacttccc aaaggacccc agtcactcca gcctgttggc tgccgctcactttgatgtct
4201 gcaggccaga tgagggctcc agatggcaca ttgtcagagg gacacactgtggcccctgtg
4261 cccagccctg ggctctctgt acatgaagca actccagtcc caaatatgtagctgtttggg
4321 aggtcagaaa tagggggtcc aggagcaaac tccccccacc ccctttccaaagcccattcc
4381 ctctttagcc agagccgggg tgtgcagacg gcagtcacta gggggcgctcggccaccaca
4441 gggaagctgg gtgaatggag cgagcagcgt cttcgagagt gaggacgtgtgtgtctgtgt
4501 gggtgagtga gtgtgtgcgt gtggggttga gggcgttgga gcggggagaaggccaggggt
4561 cactccagga ttccaataga tctgtgtgtc cctctcccca cccgtccctgtccggctctc
4621 cgccttcccc tgcccccttc aatattccta gcaaagaggg aacggctctcaggccctgtc
4681 cgcacgtaac ctcactttcc tgctccctcc tcgccaatgc cccgcgggcgcgtgtctctg
4741 gacagagttt ccgggggcgg atgggtaatt ttcaggctgt gaaccttggtgggggtcgag
4801 cttccccttc attgcggcgg gctgcgggcc aggcttcact gagcgtccgcagagcccggg
4861 cccgagccgc gtgtggaagg gctgaggctc gcctgtcccc gccccccggggcgggccggg
4921 ggcggggtcc cggcggggcg gagccatgcg cccccccctt ttttttttaaaagtcggctg
4981 gtagcgggga ggatcgcgga ggcttggggc agccgggtag ctcggaggtcgtggcgctgg
5041 gggctagcac cagcgctctg tcgggaggcg cagcggttag gtggaccggtcagcggactc
5101 accggccagg gcgctcggtg ctggaatttg atattcattg atccgggttttatccctctt
5161 cttttttctt aaacattttt ttttaaaact gtattgtttc tcgttttaatttatttttgc
5221 ttgccattcc ccacttgaat cgggccgacg gcttggggag attgctctacttccccaaat
5281 cactgtggat tttggaaacc agcagaaaga ggaaagaggt agcaagagctccagagagaa
5341 gtcgaggaag agagagacgg ggtcagagag agcgcgcgggcgtgcgagcagcgaaagcga
5401 caggggcaaa gtgagtgacc tgcttttggg ggtgaccgccggagcgcggcgtgagccctc
5461 ccccttggga tcccgcagct gaccagtcgc gctgacggacagacagacagacaccgcccc
5521 cagccccagc taccacctcc tccccggccg gcggcggacagtggacgcggcggcgagccg
5581 cgggcagggg ccggagcccg cgcccggagg cggggtggagggggtcggggctcgcggcgt
5641 cgcactgaaa cttttcgtcc aacttctggg ctgttctcgc ttcggaggagccgtggtccg
5701 cgcgggggaa gccgagccga gcggagccgc gagaagtgct agctcgggccgggaggagcc
5761 gcagccggag gagggggagg aggaagaaga gaaggaagag gagagggggccgcagtggcg
5821 actcggcgct cggaagccgg gctcatggac gggtgaggcg gcggtgtgcgcagacagtgc
5881 tccagccgcg cgcgctcccc aggccctggc ccgggcctcg ggccggggaggaagagtagc
5941 tcgccgaggc gccgaggaga gcgggccgcc ccacagcccg agccggagagggagcgcgag
6001 ccgcgccggc cccggtcggg cctccgaaac catgaacttt ctgctgtcttgggtgcattg
6061 gagccttgcc ttgctgctct acctccacca tgccaaggta agcggtcgtgccctgctggc
6121 gccgcgggcc gctgcgagcg cctctcccgg ctggggacgt gcgtgcgagcgcgcgcgtgg
6181 gggctccgtg ccccacgcgg gtccatgggc accaggcgtg cggcgtccccctctgtcgtc
6241 ttaggtgcag ggggaggggg cgcgcgcgct aggtgggagg gtacccggagagaggctcac
6301 cgcccacgcg ggccctgccc acccaccgga gtcaccgcac gtacgatctgggccgaccag
6361 ccgagggcgg gagccggagg aggaggccga gggggctggg cttgcgttgccgctgccggc
6421 tgaagtttgc tcccggccgc tggtcccgga cgaactggaa gtctgagcagcgggggcggg
6481 agccagagac cagtgggcag ggggtgctcg gaccttggac cgcgggagggcagagagcgt
6541 ggagggggca gggcgcagga gggagagggg gcttgctgtc actgccactcggtctcttca
6601 gccctcgccg cgagtttggg aaaagttttg gggtggattg ctgcggggaccccccctccc
6661 tgctgggcca cctgcgccgc gccaaccccg cccgtccccg ctcgcgtcccgctcggtgcc
6721 cgccctcccc cgcccggccg ggtgcgcgcg gcgcggagcc gattacatcagcccgggcct
6781 ggccggccgc gtgttcccgg agcctcggct gcccgaatgg ggagcccagagtggcgagcg
6841 gcacccctcc ccccgccagc cctccgcggg aaggtgacct ctcgaggtagccccagcccg
6901 gggatccaga gaaccatccc taccccttcc tactgtctcc agaccctacctctgcccagt
6961 gctaggagga atttcctgac gccccttctc ttcacccatt tcctttttagcctggagaga
7021 agcccctgtc accccgctta ttttcatttc tctctgcgga gaagatccatctaacccctt
7081 tctggcccca gagtccaggg aaaggatgat cactgtcaga agtcgtggcgcgggagccca
7141 ctgggcgctt tgtcacattc caccgaaagt cccgacttgg tgacagtgtgcttcccttcc
7201 ctcgccaaca gttccgagtg agctgtgctt tagctctcgt gggggtgggtcaagggagga
7261 tttgaagagt cattgcccca ctttaccctt ttggagaaat ggcttgaaatttgctgtgac
7321 acgggcagca tgggaatagt ccttcctgaa ccctggaaag gagctcctgccagccttgca
7381 cacactttgt cctggtgaaa ggcagccctg gagcaggtgt ttttttggaactccaaacct
7441 gcccacccaa cttgcttctg aaagggactc taaagggtcc ctttccgctcctctctgacg
7501 ccttccctca gccagaattc ccttggagag gaggcaagag gaaagccatggacaggggtc
7561 gctgctaaca ccgcaagttc ctcagaccct ggcacaaagg ccttggctacaggcctccaa
7621 gtagggagga gggggaggag tggctgcctg gccacagtgt gaccttcagaggcccccaga
7681 gaaggacacc tggcccctgc ctgcctagaa ccgcccctcc tgtgctccctggccttggaa
7741 ggggtatgaa atttccgtcc cctttcctcc ttggggccca ggaggagtggagggtcccgg
7801 gagaatattg tcagggggaa ggcagggggt gtcatgggaa tgggtgagggggctgaggtg
7861 cagaatccag ggggtccctg caggagccgc agtggtaagc tgtccagctggaagcctggt
7921 aactgttgtt ttctcttgag aggggcttcc tgtgaccttg gctgtctctgggagcagggc
7981 tggggtacct gagtggggtg catttggggt gtgtgggaag gagagggaaagaaagatgga
8041 cagtgggact ctcccctagc agggtctggt gttccgtagg ctagagtgcccctctgctct
8101 gcgagtgctg ggcgggaggg gagttggtga gagctggaga cccccaggaagggctggcag
8161 aagcctttcc ttttgggtgc tgtcaggtcc gcatgtcttg gcgtgttgaccttcacagct
8221 tctggcgagg ggaggaatga tctgatgcgg gtggggaggg ttagaggaggcctcaggcct
8281 aaggtggtgc agggggcccc ctaggggctg ggcagtgcca aggcataaaagccttccctg
8341 gtccctggtg gcatttgaag gtgcccaggt gagaggggct tggcacctcctcaccctggg
8401 agggagaaga aaccagggaa caggtaggag tgggagacag gtgaggctttggaaatctat
8461 tgaggctctg gagagatttg tgtagagagg aaaatgtggt tctcccccagggtctcctcc
8521 tgggttttta ccctctaagc aacctgtggg catgctgggt tattcctaaggactagaaga
8581 gcttggatgg gggagggtgg ttggtgccct tcggtcctcg gcacccccctccgtctccaa
8641 caccagctca ccctggtatt tgtcatgtca gcaggagaag gtcaccatgttgtttttctc
8701 gcccctagtc cttccttcct gccccagtcc aaatttgtcc tcctatttgaccttaatact
8761 taccatggct ttggaccagg gaactagggg gatagtgaga gcagggagagggaagtgtgg
8821 ggaaggtaca ggggacctcg acagtgaagc attctggggt tttcctcctgcatttcgagc
8881 tccccagccc ccaacatctg gttagtcttt aacttcctcg ggttcataaccatagcagtc
8941 caggagtggt gggcatattc tgtgcccgtg gggacccccg gttgtgtcctgttcgactca
9001 gaagacttgg agaagccaga ggctgttggt gggagggaag tgaggagggaggaggggctg
9061 ggtggctggg cctgtgcacc ccagcccctg cccatgccca tgccttgctctctttctgtc
9121 ctcagtggtc ccaggctgca cccatggcag aaggaggagg gcagaatcatcacgaaggtg
9181 agtccccctg gctgttggat ggggttccct gtcctctcag gggatgggtggatggcctaa
9241 ttcctttttc ttcagaactg tggggaggaa ggggaagggg cacaggaatataaggatcaa
9301 gaaagaaaga gctgggcacc acgaggttca ccctcagttt cgtgaggactctccgctgtt
9361 caggtctctg ctagaagtag gacttgttgc ctttttcttc tgctctttccagtaaaattt
9421 tatttggaga aggagtcgtg cgcacagagc aggaagacag tgttcagggatcctaggtgt
9481 tgggggaagt gtcccttgtt tcccctagct cccaggggag agtggacatttagtgtcatt
9541 tcctatatag acatgtccca tttgtgggaa ctgtgaccct tcctgtgtgagctggaggca
9601 cagagggctc agcctaatgg gatctctcct cccttccctg gtttgcattcctttgggggt
9661 ggagaaaacc ccatttgact atgttcgggt gctgtgaact tccctcccaggccagcagag
9721 ggctggctgt agctcccagg cgccccgccc ccctgcccaa ccccgagtccgcctgccttt
9781 tgttccgttg tggtttggat cctcccattt ctctggggac accctggctctccccaccac
9841 tgactgtggc ctgtgctctc cacctctggg gagggaaggc cctggggtcttccttcccgc
9901 gagtttccct gacctaaatc tggcgtggct gggtagtggc cagcagtggtgatgcccagc
9961 ctgttctgcc tcctccttcc ccaccccagg agccctttcc ttggcctaggacctggcttc
10021 tcagccactg accggccccc tgcttccagt gcgccactta ccccttccagcttcccagtg
10081 gtctctggtc tgggagaggc aggacaaagg tctttgtttg ctggagaaaaggttgtctgc
10141 gataaataag gaaaaccacg aaagcctggt tgttggagtg tacgtgtgtgctcccccagg
10201 cagtggaggc cagccctcct tggaggggcg gctgcctgat gaaggatgcgggtgaggttc
10261 cccgcctcca cctcccatgg gacttgggga ttcattccaa ggggaagctttttgggggaa
10321 ttcctacccc aggtcttttt accctcagtt accaacccct tgcccaggccagaccttcct
10381 gctatcccct cctgggccac aagcctggcc ctcctctgtc ccaattgtgatgaaggggca
10441 gttcaaaact tcttgattag tcatcttctc ccctatcgac ttggctttaaaaaatgacct
10501 tttcagactt ctagtctcgt tcactctttt tgatgatgct ttgccgtaacccttcgtggg
10561 tagagaagga ttctgtgccc attggtggtc tggataaaag aaatagagacctcacaggaa
10621 gcagtggact ggcctgtttc cccactgttc tttctgtttt cacacctgtggccttctccc
10681 caccttcttc ccaatcaacc tattgtgtac atagcccccc tcattgtcctttattcttct
10741 ggaaagcaga ccttggaggg aggagtgagg gggaggctca gctgtggtctctggggggtg
10801 ggggttggga gctggggtgg aagtccacga agcatacact taagatgctttggtgaagtt
10861 ctaaacttca tattacccag gctgaaaaaa gagcacttgt tcctagggctggaaatggaa
10921 gccaaaacac cacctttttc agcctgtttc agcatcttta gagatcagcccaacccactt
10981 acacagttga gcagagttgg aggcctagag aggggaggga ctggcccaaggtcataccaa
11041 ctcatggcca gagcctgggc ctcctcactg gccaggtgtt atttcttccctctgggtagg
11101 gaacctattt cagggacagg attgctatgt ggtagtggtg gtggggtgcgataggcgtgg
11161 caggctgggc cacaatttgg agtagtcatg ccagagtcct gcatttatttattctcaagg
11221 gccccgcctc tgtggcccag aattacccct tcatgctcca gtgcaccccaggcttcgtgg
11281 ccagcctggg aaactgtctc taccctggtc tcccttcaga tcagcttctagaaatgtttc
11341 gtggctacag tggcagcact gttttttcca tgatgcaagc agtttgccctcttgggcggg
11401 gttatcagtg gctggcaggg ctggcacagc gtgtccgccc actgccacctgtgggttcca
11461 ggagggccca gcccctgtgc tgatgcccac caccttctca gctcatgtctggggaagagg
11521 actggcaggg ggaaaggtgc ctcctcctga aaggtgcctc ctctgtttttgcctaatata
11581 ggcttgggaa cactttgatg tcagctaatt ctgactcctt tacttactagctgtgcggcc
11641 ttggggcaac ttacttagcc tctttgagcc tcctgttccc catctgtaaaatggaatctc
11701 aatagtgtct aatagtacca tgtggagaaa cttgtgtgaa atgatagctgtggactactg
11761 tacacagtac tcaggatgta gtaagtgctc aataaacagc tgttggtatggttgacgtta
11821 tggtagtggt tgtggggagg acgtaggaaa ctggagacta gcttggcaaagctggctctt
11881 cctcctttta gggaaagctt agagcatccc catggggtat acccatactcagactgtcct
11941 ctggcatcga ggttggccca ggattcagtt cagctgtcac agtgaggtggcgggatcaga
12001 tgtggcaggc catgtccctt ggaacttgag tacatcgtgt gatctctggaatgaaaacag
12061 gccttcacca gtgttgatgg tggaaagctt agggaagtgc ttcaaacacagtaggaggga
12121 cttacgttag attttggaag gacttgcctg attcggaagc tccaaagagtggcattacag
12181 agctgggtgg agagaggggc tagccatctt ttgtgtcgcc caccgggctcatgtgtcatc
12241 gcctctcatg cagtggtgaa gttcatggat gtctatcagc gcagctactgccatccaatc
12301 gagaccctgg tggacatctt ccaggagtac cctgatgaga tcgagtacatcttcaagcca
12361 tcctgtgtgc ccctgatgcg atgcgggggc tgctgcaatg acgagggcctggagtgtgtg
12421 cccactgagg agtccaacat caccatgcag gtgggcatct ttgggaagtggggcaagggg
12481 gggataggga ggggggtaac actttgggaa caggtggtcc caggtcgtttcctggctaga
12541 tttgccttgt ctggctcctg cccctgagtt gcacagggga ggtatggtggggtcttgcct
12601 tctgtggaga agatgcttca ttcccagccc aggttcccag caagccccaaccatctcctt
12661 ctccctgatg gttgcccatg ggctcaggag gggacagatg gatgcctgtgtcaggagccc
12721 ctctctccct ctcttggaga gagtcctgag tgccccccct tcttgggggctttgtttggg
12781 aagctggatg agcctggtcc atggagagtt taaaaagtct tttggtgttacctggtaatg
12841 gggcacatct cagcccagat agggtgggag ggagctgtga aacacagggagggggttgct
12901 ttcgggtatc tactaggagt cagggtgaag cctagagagg atgaaagaaggggaggggat
12961 ggggagtggt aagaacctag gatttgaatt cccagcctgg ccaacccttgcagccatgtc
13021 ttggcctcaa gtggaacaag ggctccttga ggccagcagg gttgggggagttggggtggg
13081 cctgagcctc tttcctgcta gagctcttgg tcctccctgc ctccaccacccatccctgct
13141 ctgcagaacc cctgggtgct gagtggcagg agccccaggg ttgtcccatctgggtatggc
13201 tggctgggtc actaacctct gtgatctgct tccttccttt ccagattatgcggatcaaac
13261 ctcaccaagg ccagcacata ggagagatga gcttcctaca gcacaacaaatgtgaatgca
13321 ggtgaggatg tagtcacgga ttcattatca gcaagtggct gcagggtgcctgatctgtgc
13381 cagggttaag catgctgtac tttttggccc ccgtccagct tcccgctatgtgacctttgg
13441 cattttactt caatgtgcct cagtttctac atctgtaaaa tgggcacaatagtagtatac
13501 ttcatagcat tgttataatg attaaacaag ttatatatga aaagattaaaacagtgttgc
13561 tccataataa atgctgtttt tactgtgatt attattgttg ttatccctatcattatcatc
13621 accatcttaa cccttccctg ttttgctctt ttctctctcc ctacccattgcagaccaaag
13681 aaagatagag caagacaaga aaagtaagtg gccctgactt tagcacttctccctctccat
13741 ggccggttgt cttggtttgg ggctcttggc tacctctgtt gggggctcccatagcctccc
13801 tgggtcaggg acttggtctt gtgggggact tgtggtggca gcaacaatgggatggagcca
13861 actccaggat gatggctcta gggctagtga gaaaacatag ccaggagcctggcacttcct
13921 ttggaaggga caatgccttc tgggtctcca gatcattcct gaccaggacttgctgtttcg
13981 gtgtgtcagg gggcactgtg gacactggct cactggcttg ctctaggacacccacagtgg
14041 ggagagggag tgggtggcag agaggccagc ttttgtgtgt cagaggaaatggcctctttt
14101 ggtggctgct gtgacggtgc agttggatgc gaggccggct ggagggtggtttctcagtgc
14161 atgccctcct gtaggcggca ggcggcagac acacagccct cttggccagggagaaaaagt
14221 tgaatgttgg tcattttcag aggcttgtga gtgctccgtg ttaaggggcaggtaggatgg
14281 ggtgggggac aaggtctggc ggcagtaacc cttcaagaca gggtgggcggctggcatcag
14341 caagagcttg cagggaaaga gagactgaga gagagcacct gtgccctgccctttccccca
14401 caccatcttg tctgcctcca gtgctgtgcg gacattgaag cccccaccaggcctcaaccc
14461 cttgcctctt ccctcagctc ccagcttcca gagcgagggg atgcggaaaccttccttcca
14521 ccctttggtg ctttctccta agggggacag acttgccctc tctggtcccttctccccctc
14581 ctttcttccc tgtgacagac atcctgaggt gtgttctctt gggcttggcaggcatggaga
14641 gctctggttc tcttgaaggg gacaggctac agcctgcccc ccttcctgtttccccaaatg
14701 actgctctgc catggggaga gtagggggct cgcctgggct cggaagagtgtctggtgaga
14761 tggtgtagca ggctttgaca ggctggggag agaactccct gccaagtaccgcccaagcct
14821 ctcctcccca gacctcctta actcccaccc catcctgctg cctgcccagggctccaggac
14881 acccagccct gcctcccagt ccaggtcgtg ctgagcaggc tggtgttgctcttggttccg
14941 tgccagctcc caaggtagcc gcttccccca caccgggatt cccagaggttctgtcgcagt
15001 tgcaaatgaa ggcacaaggc ctgatacaca gccctccctc ccactcctgctccccatcca
15061 ggcaggtctc tgaccttctc cccaaagtct ggcctacctt ttatcacccccggaccttca
15121 gggtcagact tggacagggc tgctgggcaa agagccttcc ctcaggctttgccccctgcc
15181 ggggactggg agccactgtg agtgtggaga cctttgggtc ctgtgccctccacccagtct
15241 cggcttccca ccaaagcctt gtcaggggct gggtttgcca tcccatggtgggcagcgtga
15301 ggagaagaaa gagccatcga gtgcttgctg cccagacacg cctgtgtgcgcccgcgcatg
15361 cctccccaga gaccacctgc ctcctgacac ttcctccggg aagcggccctgtgtggcttt
15421 gctttggtcg ttcccccatc cctgcccacc ttaccacttc ttttactccccccaccgccc
15481 ccgctctctc tctgtctctg tttttttatt ttccagaaaa tcagttcgaggaaagggaaa
15541 ggggcaaaaa cgaaagcgca agaaatcccg gtataagtcc tggagcgtgtacgttggtgc
15601 ccgctgctgt ctaatgccct ggagcctccc tggcccccag tacaacctccgcctgccatt
15661 ccctgtaacc ctgcctccct cccctggtcc ttccctggct ctcatcctcctggcccgtgt
15721 ctctctctca ctctctcact ccactaattg gcaccaacgg gtagatttggtggtggcatt
15781 gctggtccag ggttggggtg aatgggggtg ccgacttggc ctggaggattaagggagggg
15841 accctggctt ggctgggcac cgattttctc tcacccactg ggcactggtggcgggcccat
15901 gttggcacag gtgcctgctc acccaactgg tttccattgc tctaggcttctgcactcgtc
15961 tggaagctga gggtggtggg gagggcagac atggcccaag aagggctgtgaatgactgga
16021 ggcagcttgc tgaatgactc cttggctgaa ggaggagctt gggtgggatcagacaccatg
16081 tggcggcctc ccttcatctg gtggaagtgc cctggctcct cacggaggtggggcctctgg
16141 aggggagccc cctattccgg cccaacccat ggcacccaca gaggcctccttgcagggcag
16201 cctcttcctc tgggtcggag gctgtggtgg gccctgccct gggccctctggccaccagcg
16261 gcctggcctg gggacaccgc ctccgggctt agcctcccat cacaccctactttagcccac
16321 cttggtggaa gggcctggac atgagccttg cacggggaga aggtggcccctgattgccat
16381 ccccagcagg tgaagagtca aggcgtgctc cgatgggggc aacagcagttgggtccctgt
16441 ggcctgagac tcacccttgt ctcccagaga cacagcattg ccccttatggcagcctctcc
16501 ctgcactctc tgcccgtctg tgcccgcctc ttcctgcggc aggtgtcctagccagtgctg
16561 cctctttccg ccgctctctc tgtcttttgc tgtagcgctc ggatccttccagggcctggg
16621 ggctgaccgg ctgggtgggg gtgcagctgc ggacatgtta gggggtgttgcatggtgatt
16681 ttttttctct ctctctgctg atgctctagc ttagatgtct ttccttttgcctttttgcag
16741 tccctgtggg ccttgctcag agcggagaaa gcatttgttt gtacaagatccgcagacgtg
16801 taaatgttcc tgcaaaaaca cagactcgcg ttgcaaggcg aggcagcttgagttaaacga
16861 acgtacttgc aggttggttc ccagagggca agcaagtcag agaggggcatcacacagaga
16921 tggggagaga gagagagaaa gagagtgagc gagcgagcga gcgggagagcgcctgagagg
16981 ggccagctgc ttgctcagtt tctagctgcc tgcctggtga ctgctgccttctctgctttt
17041 aaggcccctg tggtgggctg caggcactgg tccagcctgg cggggcctgttccgaggttg
17101 ccctggttgc ctgagtggta ggctggtgtg gcttagtgta gtggtgtggacgcaagctgt
17161 gtgttgtgtc ctgtggtcct tctgctcata gtggctgttg gtcctgatgttattactacc
17221 tctggtagta atgctgagaa gctgaaagcc gattccaggt gtggacaatgtcaacaaagc
17281 acagatgctc tcgctggggc cttgcctcgg ccctttgaag tctgcatggctgggcttctc
17341 actcactcag tgtttcttgc tgggggaagg aattgagtct cccacttcagactgggcctc
17401 cctgaggaaa gggttgtgtc tccccactca gactgaggtt ccctgagggtagggctgtgt
17461 ctctcccctc cgacctgggc tccctgatag ggctgtctcc ccgctcagactgaggctccc
17521 tcaggccagg gctatgtctc cctcctcaga ctggggctct gagggcaaggggtctggctg
17581 ttcgtttagg atggggcact tttgcctaca cactgaagga gctgtagcatccaagaatac
17641 tagatacctt taatcctcca ccagtcatgg tgacaacccc aagcagcccacacattttca
17701 agtgccccca ggatgcgtgg agggaggggt ctgtgcccat tctcctgacattagcctgtg
17761 agctccgtaa gcccgggcct cgtttacgta cctttgtgag ccccgggcatctgtacctct
17821 ttcctttgcc catactgggg accaaggaag tgtcaagtgc atgagtgaatgtgtgactca
17881 gttcagaggg tgaggtcagg agcacagggt cgggacaggt ggctggcatcttttaatgcc
17941 ttagcttatg ttctttatac caacttggcc tgtgctcaga gtgagggaggccctgggggt
18001 cagggtaagc gtcagtcagg gaggcaagac tttgtgggga tttcctagacagggccaagg
18061 cacccccagc tcaccccgag gctgtgttag ggaagtcctt ggagtgtctcccctccccca
18121 gcaatgttct tgtggcttgt gtgtgctcag gggatgctgg gaaccaggcctgggtagttg
18181 gtgtggggtg ctgtctgtct tggccctatg tgaaaccaag agggcgtatattagtgctgg
18241 ggtgggggct ctgcctaact tcagggctgg atgaggggag tctcagttccccaggggtcc
18301 ttgggaaaga taagggactt gacattttag ggtttttagg tgattattctgctgatgggg
18361 gtttgtgtga agtgacctgg gagctaactg aagttactct aacctcccaatacctttacc
18421 caacccccaa gctggctgta tctgggaata tcagtttcca aaattggaggcttaggactc
18481 cgtttcgggg ctccccagaa gggtagggcc tgttctgcct ccttctcacaatcacccagg
18541 ggcaggggca tgctgagaaa gttcttggag gccccctttg cttcagctggagtagtgaag
18601 ccgccgaatt gtctctcccc atcctaagtg aagcagcata tttgaaaggaaagacaacct
18661 gttacctggg cctgcaacct ccaggcagct caagagagat gaggcctacagccacagtgg
18721 gaggggacat ggggaatgga gatggtccct caccttcctg gggcctcctgctctacgcta
18781 ccccctcggg agcctcctgt ccccagggca ggcccttgcc attgttggtcacccggccaa
18841 gcctctctgc ctcaggcgtt ctcccagaag atctgcccac tctcttccccacaccagccc
18901 ctagagactg aactgaaaac cctcctcagc agggagcctc ttctgattaacttcatccag
18961 ctctggtcac ccatcagctc ttaaaatgtc aagtggggac tgttctttggtatccgttca
19021 tttgttgctt tgtaaagtgt tcccatgtcc ttgtcttgtc tcaagtagattgcaagctca
19081 ggagggtaga ctgggagccc ctgagtggag ctgctgctca ggccggggctccctgagggc
19141 agggctgggg ctgttctcat actggggctt tctgccccag gaccacaccttcctgtcctc
19201 tctgctctta tggtgccgga ggctgcagtg acccaggggc ccccaggaatggggaggccg
19261 cctgcctcat cgccaggcct cctcacttgg ccctaacccc agcctttgttttccatttcc
19321 ctcagatgtg acaagccgag gcggtgagcc gggcaggagg aaggagcctccctcagggtt
19381 tcgggaacca gatctctcac caggaaagac tgatacagaa cgatcgatacagaaaccacg
19441 ctgccgccac cacaccatca ccatcgacag aacagtcctt aatccagaaacctgaaatga
19501 aggaagagga gactctgcgc agagcacttt gggtccggag ggcgagactccggcggaagc
19561 attcccgggc gggtgaccca gcacggtccc tcttggaatt ggattcgccattttattttt
19621 cttgctgcta aatcaccgag cccggaagat tagagagttt tatttctgggattcctgtag
19681 acacacccac ccacatacat acatttatat atatatatat tatatatatataaaaataaa
19741 tatctctatt ttatatatat aaaatatata tattcttttt ttaaattaacagtgctaatg
19801 ttattggtgt cttcactgga tgtatttgac tgctgtggac ttgagttgggaggggaatgt
19861 tcccactcag atcctgacag ggaagaggag gagatgagag actctggcatgatctttttt
19921 ttgtcccact tggtggggcc agggtcctct cccctgccca ggaatgtgcaaggccagggc
19981 atgggggcaa atatgaccca gttttgggaa caccgacaaa cccagccctggcgctgagcc
20041 tctctacccc aggtcagacg gacagaaaga cagatcacaggtacagggatgaggacaccg
20101 gctctgacca ggagtttggg gagcttcagg acattgctgt gctttggggattccctccac
20161 atgctgcacg cgcatctcgc ccccaggggc actgcctggaagattcaggagcctgggcgg
20221 ccttcgctta ctctcacctg cttctgagtt gcccaggaga ccactggcagatgtcccggc
20281 gaagagaaga gacacattgt tggaagaagc agcccatgacagctccccttcctgggactc
20341 gccctcatcc tcttcctgct ccccttcctg gggtgcagcc taaaaggacctatgtcctca
20401 caccattgaa accactagtt ctgtcccccc aggagacctg gttgtgtgtgtgtgagtggt
20461 tgaccttcct ccatcccctg gtccttccct tcccttcccg aggcacagagagacagggca
20521 ggatccacgt gcccattgtg gaggcagaga aaagagaaag tgttttatatacggtactta
20581 tttaatatcc ctttttaatt agaaattaaa acagttaatt taattaaagagtagggtttt
20641 ttttcagtat tcttggttaa tatttaattt caactattta tgagatgtatcttttgctct
20701 ctcttgctct cttatttgta ccggtttttg tatataaaat tcatgtttccaatctctctc
20761 tccctgatcg gtgacagtca ctagcttatc ttgaacagat atttaattttgctaacactc
20821 agctctgccc tccccgatcc cctggctccc cagcacacat tcctttgaaataaggtttca
20881 atatacatct acatactata tatatatttg gcaacttgta tttgtgtgtatatatatata
20941 tatatgttta tgtatatatg tgattctgat aaaatagaca ttgctattctgttttttata
21001 tgtaaaaaca aaacaagaaa aaatagagaa ttctacatac taaatctctctcctttttta
21061 attttaatat ttgttatcat ttatttattg gtgctactgt ttatccgtaataattgtggg
21121 gaaaagatat taacatcacg tctttgtctc tagtgcagtt tttcgagatattccgtagta
21181 catatttatt tttaaacaac gacaaagaaa tacagatata tcttaaaaaaaaaaaagcat
21241 tttgtattaa agaatttaat tctgatctca aagctcctct tggtttctccttctccattg
21301 aatccttgct ctagacttcc tcccgccccc tttccctctt cctctggggaacatggcatt
21361 tgtcttgggt ctgggaaagg tacgtctaat gtgtaggata tggggtgacccaccttgttg
21421 tgctgggggc aaagtccttc cattttggct gagctggtcc tgggggaacccatccatcct
21481 gtcttgatat agaaggtggg aagctctggg aatgggtgga gggggagaaacagcttagga
21541 gccaagggcc cttgcaattg gtagtgctgc cttcaggaat tagatgatccaggcccctgt
21601 cccttagcca gggaaagaac tggccatgtc tccaagcttg ctgcccaggagacaggagag
21661 agctgttttt gtctgtgggg gtcttgttgg ctgcaacagg ctgggagtgggagggggatg
21721 ctgctggagg gctgtgactc cagggtgtaa cttaatttta catagttttacaccctggag
21781 ttccttgagc ctctggaaga tggacccata ggtttggtca ccactgatgggacactccct
21841 gccccagctt gccataagct cttctctcac gtcctgctcc tgggtaaggtggcacctatc
21901 caggtctttg acactgaagg gcagtgcttc caaattcact tcctctagcctctcatttat
21961 tcttgcaaac catagatatg gcttgaataa atattgagcc agtcattgtgctgctatgaa
22021 taagacacaa ttccacccct caaggatctg gtgaggatgg gtgggtggggagacccaaaa
22081 ctataaatcc atgagcagaa aaatacataa aatgtgctgg gggcatctgatctagcttgg
22141 gagtgggagt tgtattgggg gtggtggctg gggggtggtg tcttatgacattatctctag
22201 gctgccactt aaagtatggt ttgaagacag ggagaacggg gcggcggagtgaaagggttg
22261 aggacatccc aggcagaagg gatagtgtga gcaaggcatg aaggtggcacttgggcaggg
22321 gcagggagtg ggtgggcagg gtggaggctg gagacacggg caagggttagctccaaggga
22381 gcctgcagca ccatgccaag agcctagggc ctgtcaggga tgagcagcagccgaggggtt
22441 ttaaacactg agcggctcag tcagatagac ttttccatag gtgcctggcaacagtatggg
22501 aggcagagag gccggtagag gctgttgtgg tcttccagga ggaattgtgctggtggtggg
22561 gaagcacctt tggtgactgg cagtgccggc cattgcaagg tctcagcctcaggcagcttt
22621 tggtctagta agtgctcctt tcccaatcac tgaccacgtg ccgacccctacattggttaa
22681 cactgaatct gcacagcagc cctgggaggt aggtgctttt tttttttttttttttttttt
22741 gagatggagt cttgctctgt cacccaggct ggagtacaat ggtgcgatctcgggtcactg
22801 caacctccgc ctcccaggtt caagggattc tccctcctca gcctcccgagtagctgggat
22861 tacaggcacg caccatcatg cccgactaat ttttgtgttt tcgtagagacggggtttcac
22921 catgttggcc aggctggcct caaacccttg acctcaggtg atctgcccgccttggcctcc
22981 caaagtgctg gcattacaga tgtgagccac cgcgcccggc aggtaggggcttttttcatc
23041 ccatctggat ttttgctgga gcctttaaat tggccgcctg gcttctcctctggccttcct
23101 ttagttgaat ctcacacaac tgccagagtg agcctgttaa aatgtgagttaagttttggc
23161 accttttgac tcaaaacctt ccagagatag ttttactcgg agaaaaacccaaatggcctt
23221 aaaaggcctg caccatttgg gctgcctccc tgactactca atgacttcgg gc
人VEGF-B基因(SEQ ID NO:81)(NCBI登录号NG_029823.1)
1 gccgtccccg ccgccgctgc ccgccgccac cggccgcccg cccgcccggc tcctccggcc61 gcctccgctg cgctgcgctg cgctgcctgc acccagggct cgggaggggg ccgcggagga 121gtcgcccccc gcgcccggcc cccgcccgcc gcgcccgggc ccgcgccatg gggctctggc 181tgtcgccgcc ccccgcgccg ccgggctagg gcgatgcggg cgcccccggc gggcggcccc 241ggcgggcacc atgagccctc tgctccgccg cctgctgctc gccgcactcc tgcagctggc 301ccccgcccag gtacgtgcgg cccgacagcg cgcccgcccg cccgccgtgc cctctctcaa 361ggttggcgga agtgaggagg cgacccgcgg cctcggccga ggggatctgc ggggtccggc 421cttggacgcg ggcgtctcgg gggcccggcg cgtgcatccc ctgggaggtg cccctccccg 481ctggcccgcc agccccagtc tggggccact cctccgcccc accccgtccc ctgggcaccg 541ccgggggcgg ggctccctcg gtgcctgcag gacctgcttc ggtgggcact gtgcgcgctc 601ctgatctgca tgcagccccc aaacatgctc ggctccgcgg cctggagatt tggcgcggcc 661accagagcac ctgttgcgtt ttgggccagg gcaggtcccg ggtggccagg agaggacagg 721taaagctaga gcagtggccg caggaacaga gcaatctgga aagatgtcag agaggtggtg 781aagcctactg atgcaagggc aaagccccag ggacggtgac agggccacac cctcctaaag 841tgtaccttgg gtacaggtct tttctctccc acaggcccct gtctcccagc ctgatgcccc 901tggccaccag aggaaaggta atacttacaa aaactcggca ctagccagca ctaagagggt 961ttgtcatggg ccctgattcc aggtgtccat catcttgtgt aactccccta gaagattcaa 1021actattattc tacccatttc acagaggagg aaattgaggc agtggggtta ctgggatctg 1081gataaacagg gcaggggaag acaggttgtg agggcagagt ggggagggct agtggagggt 1141ggctgtgact tggggactgg ggaggacaga tgctgggagc agctgcagga aaaccagtga 1201ggacttaacc cctaccggtc tgctcccagt ggtgtcatgg atagatgtgt atactcgcgc 1261tacctgccag ccccgggagg tggtggtgcc cttgactgtg gagctcatgg gcaccgtggc 1321caaacagctg gtgcccagct gcgtgactgt gcagcgctgt ggtggctgct gccctgacga 1381tggcctggag tgtgtgccca ctgggcagca ccaagtccgg atgcaggtac tgggcaggtg 1441gggcaacggg caggggatgc aggtactggg caggtggggc agcgggcagg gtggatgctg 1501gctggctctg gggctggggc agcctggaga ctgatgcaca ggagacaggg ttggggggag 1561ggctggtggc cagcctcccg gctgttgggt gagcttttct cccttcagtc ttagagcatc 1621ccctttctct ctctccctca ctgtcccccc tgttcttctc ctgagcacag atcctcatga 1681tccggtaccc gagcagtcag ctgggggaga tgtccctgga agaacacagc cagtgtgaat 1741gcaggtgcca gccaggccca acttctgagc tcgcagaggc caggcttggg gggtgctggg 1801tatggtggtc cacagaactg gggaccaggt tcctaagagt agaaccaagg ggccgggcgt 1861ggtagctcac gcctgtaatc ccagcacttt gggaggccga ggcgggcgga tcatgaggtc 1921aggagatcga gaccatcctg gctaacatgg taaaaacctg tctctactaa aaaaatacaa 1981aaaattagcc gggcgtggtg gcgggcacct gtagtcccag ctactccgga ggctgaggca 2041ggagaatggc atgaacctgg gaggcgtagc ttgcagtgag ccaagatcgt gccactgcat 2101tccagcctgg gcgacagagc aagactctgc cacaaaaaaa aaaaaaaaaa aaaaaaaaaa 2161agagtagagc caagggtagg ccttggatct ggggcaacaa agtaggatgc ttgggccggg 2221ggtagtggct cacacctata atcccagcac tttgggaggc ccaggcaggc agatcacctg 2281aggtaaggcg tttgagacca gcctggccaa catggtgaaa ccccatctct actaaaaaaa 2341aatacaaaaa ttagccgcgc atggtggcag gtgcctgtaa tcccagctac ttgggaggct 2401gagacaagag aatagcttga acctgggagg cggaggttgc agtgagccga gaccacgcca 2461ctgcactcca gcctgggcaa gaagagggaa acacagtctc aaagagagag agagagagag 2521agagagagag agagagagag taggatgctg ggatttcctg atcttcctct tgtttgtctg 2581tgtctgtcta tcttactttt cagacctaaa aaaaaggaca gtgctgtgaa gccagacagg 2641tgagtctttt ggactccagc tgagtagggg tatggggagt acaagtgagt ccagaagctg 2701ttgctcctct ttctcctccc acccgtcccc cactttccct tttcctctgc tccccaagcc 2761tgtgttctct gccccgaccc cagctctagg gaagactctt ccttcccacc ccagacatgt 2821cgcttctcct ccctagggct gccactcccc accaccgtcc ccagccccgt tctgttccgg 2881gctgggactc tgcccccgga gcaccctccc cagctgacat cacccatccc actccagccc 2941caggcccctc tgcccacgct gcacccagca ccaccagcgc cctgaccccc ggacctgccg 3001ctgccgctgc cgacgccgca gcttcctccg ttgccaaggg cggggcttag agctcaaccc 3061agacacctgc aggtgaggcg tctgtggggt ggtgtttgtt tgggaaggca ccaaggccct 3121gtcctggagc aggtccaggg tgagcctgcc agtaggagga gggccaggga aggggaaact 3181gttgaatgtg ttgaacaaat atttaccaaa cagctgctgg cacctggagc tgtataagca 3241agtccaacat tctaactcag gagtcagata caggagggac aatgccagca gaggatgtca 3301agggctgtgg tgaggggtac ctggcctcgt ctttcagagg tcagagatct cttggaggag 3361gtgacatctg cccggagtag aaatgtagga cacagctttt ccagcttgca gttcgggcct 3421tcccagaagc ccctgtggta gacatctgcc cttacctacg ggcttcaaga ggccagggga 3481catagtggaa cccttgtcca cccttacctg atgtgtttct caccatccgt gtcccgcagt 3541gaggccatgg ggtgaaatca tatgggcagg gccagtgggg gctcccgagg agtgtcagga 3601ggggatgacc tttgcaaaag gttcatcctt cgccctgcag cctccagtgc ccagggccga 3661gtggtgtggc aggatgctca ggttgtgatc ttagtgggcc cgaggcacac atgagtccag 3721ggctggggct gcgctccagc cagcatgaac agatcacttc ctccctcctc aggtgccgga 3781agctgcgaag gtgacacatg gcttttcaga ctcagcaggg tgacttgcct cagaggctat 3841atcccagtgg gggaacaaag aggagcctgg taaaaaacag ccaagccccc aagacctcag 3901cccaggcaga agctgctcta ggacctgggc ctctcagagg gctcttctgc catcccttgt 3961ctccctgagg ccatcatcaa acaggacaga gttggaagag gagactggga ggcagcaaga 4021ggggtcacat accagctcag gggagaatgg agtactgtct cagtttctaa ccactctgtg 4081caagtaagca tcttacaact ggctcttcct cccctcacta agaagaccca aacctctgca 4141taatgggatt tgggctttgg tacaagaact gtgaccccca accctgataa aagagatgga 4201aggagctgtc cctgcctgtg tcactgtttg tcactgtcca ggctggctgg tttgggcatg 4261aatgtctgca tcactaaatc cagagcttgt cttgctccct cattgtgcag atggaggaaa 4321tgaggactaa ggccccacag cagatcccag gcagggccag aattatgtat tcatcacttt 4381caagttattg ccacgcatgg gagtcaggga tagcccagtc aatacagact gcctgccctc 4441ctgctcttca ccagggttct tttctagaag gagacagcct tctgtggcca gagagcttgg 4501ggtaggaccc agatctactg agtgaccttg cttgtcacta cccctgcctc tctgagcagc 4561agtttccaca tgtgcacata gagggaacag aagattgctg tggttggcgt cctcgggccc 4621cagagaagtt tgagactatc tttacgtaat agaaaagaac acttgttctt cctgccaggc 4681a
人VEGF-C基因(SEQ ID NO:82)(NCBI登录号NG_034216.1)
1 acttcgggga aggggaggga ggagggggac gagggctctg gcgggtttgg aggggctgaa
61 catcgcgggg tgttctggtg tcccccgccc cgcctctcca aaaagctaca ccgacgcgga
121 ccgcggcggc gtcctccctc gccctcgctt cacctcgcgg gctccgaatgcggggagctc
181 ggatgtccgg tttcctgtga ggcttttacc tgacacccgc cgcctttccccggcactggc
241 tgggagggcg ccctgcaaag ttgggaacgc ggagccccgg acccgctcccgccgcctccg
301 gctcgcccag ggggggtcgc cgggaggagc ccgggggaga gggaccaggaggggcccgcg
361 gcctcgcagg ggcgcccgcg cccccacccc tgcccccgcc agcggaccggtcccccaccc
421 ccggtccttc caccatgcac ttgctgggct tcttctctgt ggcgtgttctctgctcgccg
481 ctgcgctgct cccgggtcct cgcgaggcgc ccgccgccgc cgccgccttcgagtccggac
541 tcgacctctc ggacgcggag cccgacgcgg gcgaggccac ggtaggtctgcgttagggtt
601 tgcggagaac ccgagagttt gcgttagggt ctgcggcgga cccgagaacctgcgcggggg
661 aaagtgtgtg tgctttaagc ttgtgtacgt gggatccaaa gttactgagctcagtgcacg
721 ctgctttgga gaaaaatctt cttcttttta aatagaaagt tgttactagagaggcaagca
781 agttacacga gtgaagggcc cggagaggtg cccagtgaga gatcccgaaatctatttcag
841 actggtttcc tctggggcaa ccaaggggtc ttgaaccctg cccagtcagcggggctctgg
901 agagtatgag ttcattttgg tcgggaaatg ctcgtttctt tccccagctgattcatggga
961 ctccaaacag attctgggac actggtgatc agtcaaccca gccttactttcctggagtgt
1021 tcatagtctg cagagcacca ggcgctgtga gcgactttag aaaaaaagtgtcagggactt
1081 tagtaaccag gctccagagc tttcagagtt cacttgaagt tggtcagacttgagatgtaa
1141 cgggagatta gagtcagtta gatcacaatc aagcaatgca aggcttgtttcaactttata
1201 agctcttcat tcctaaaatc tggtcatgag atactgcaaa ctaagtttttttttttcttg
1261 tttgggtttt ttgtttgttt tgttttcttt taaataagag gtgtttaatcctttgcctga
1321 aaatgttgcc aaaatacttt tgaggcatcc tgattttgaa aaaggatttgtgtgtgttcc
1381 tacttcttac tggctcttcc aaaagagtat atctttatct aaaaagttcatacctgccat
1441 aaccatatag agtatgctta agagagttcc taaagaagtt atattcgacatttcagttca
1501 aacacttgca gtaccccttg ctggaactat actgcggtag tttatttcaactggtggcaa
1561 gtggagaggt acctgtggtg tgttacagtc aactttaatt tgactgttgattaacacata
1621 cacaatgtgt agaaaatagc cttatatttt gaaatatttt atttatatttatattttgaa
1681 atacacttaa agattgagaa gactaatttt tggaaatcaa actacctttgcatttaaatt
1741 ttgggaaaac attaaaatgt tggaatgtgt aataatttaa tataggggttaaaggaatgc
1801 ctcttgagta aaaacaatat acatgaaata gaacagactg cattctgtgaatcacaaaaa
1861 taattttcag tgcctatact tacattgccg taactatagt gatgaaaatatctttctgtt
1921 cttaaatacc gcagaaatgt aataatcggc tcaataacgc ttctgataatttgagtcctt
1981 gattttgcag tacctatttg ctatttctgc aaagtcaaaa ctagtaaaagtatgatttag
2041 taaggcaaca tctctgtatt ggttacggtc acttactttg gtttacagtaagaaaatgtg
2101 cagtagagag taaaatgaga aacattccct gataagccaa tagcctgtatgagagtcact
2161 cactgctggg tgagtctaga attaatgtac cttgagtgtg tgtgtgtgtgtgtttacgtg
2221 tgttatgtat aggtatggga ttggaggatt aaaaaagtta acttatttttaactttcaaa
2281 agtgtcttcg ttggtgatgt aaaatttgcc attggtgata tggcaaattttaccattgct
2341 gtgaaaatca ctatgcattt ttgtttgcaa atgtcgcttt tcatatttaaccatttttat
2401 attctgtatg gtgaatatgg gttagtattc tgcatgtgat gtgggttcctttcctatgtg
2461 atgaaacatc atttcccata tgaaacatca tctctgagtt ccatagaccacaaagcagta
2521 tttcattgct ccattaaagt gtcgttcccc agtgggtgaa tagagccttgacagggcatg
2581 tgtcattaat gcattcagtg aaactgctgt gtccttgcta tgaaacatgtcacacaactg
2641 ccaagaaact gatatgaaga ctctatgtct ctccctagtg gcctgtacaagcaccacatt
2701 tagatttaag cactagagaa gaactgggga gaaatcaatt gttaattttctataactaca
2761 tgaaccccaa gaaaatattt cagaaggtaa acagaagatg ctaaatatctataatcccaa
2821 tagatgcaat gttttcataa ctttcaccta ggaacttttt taatatttaaaaaatcaaaa
2881 atagcacaca aactatgaac caaggttagc catccagccc ttcagcccacccgtaaagcc
2941 atgcaaaaga ttgtaggtaa aaatcacaaa tagaatgaag atctccttattcctcgactt
3001 atatttgcat ttactggatt cctatttcta gttatttgtg gttgcatgacttactgaaaa
3061 gtcttaaaat gtttctctga aggatgttaa cacaaacaag acagtgtcaaaaaagtaagg
3121 caggcaaaag taaaattaac tggacatgat gggaacaaaa gagaatagcaagtctgaagc
3181 tgttctattt acaatttttc ttatagtata tgattatgtt tgtcaacatctactcttata
3241 agagatttct gacattcctc tgagtgatgc tacttatatg aggttttagatatagaaagt
3301 tcaattcatc tttcattttg atttccactc cattatagtc ttctgaactatgaatatctg
3361 attgatagct atttattcac aagacagtta tcaaaattgc ttcatagaaagcagttaatt
3421 actgatctta gtggcatatg tctaagaccc gtagatctct aatcctgtccttttcagttg
3481 agttgagaaa gacggagggt agtggattta gatttcattt tggacttccagttctggttc
3541 cggttcctct tgagaggaag gtcctggcct cctagttatc tccatgtgtccaacccagaa
3601 tgctgtttct cagctcttgc tggggttttc accaacagag gaactggcgtgagactaatg
3661 aaggtttccc gaatccctgg gactgtgctt gcctgcttgc ctttggcagtcctggggttg
3721 ttattgagag taggagttta taatcattat ctgtgatgtt cataacgtgtgttaagcact
3781 tcgcaaagag ctttgcaagt tagttttgtt tttcactaca cctccataatatggacatta
3841 ttttatttca ttaaggatga tgaacccaag atctgaatga cttaaccaggaaaaagaata
3901 gatgtttttt tccttttttt cttttaaaaa aagttttatg gcatataccaacagtccccg
3961 acttagaatg gttctattta ggacttttgg actttacaat ggtgcaaagtcgatagacat
4021 tcagtagaaa ccatacttca aggtttgaat tttgatcttt tcctgggctaataatatgca
4081 gtaaaatact ttctctggat gctggacaat ggaagtgagc tgtgaccagtcagccatgtg
4141 atcgtgagag taaacaacag gtactctact gtatattaaa tatattttcaactcaggagg
4201 aatttgtcag gatgtagccc catcgtaaat cgagaagcat gtatgttttagagaaatgtg
4261 gtaatgggtt tgggcctttg ggcctgtgat tcagactcct ttcagcccctctgctggtct
4321 cctttggcac actatagcag cgtgcaggaa ggcagagaaa agcactgcgtgtgactttgc
4381 agttaggggc accttgttgc atttatttag gtcctaattc cccacaacgggacaaacgga
4441 aataaaccca gactttcttc caggctttac cacatggtgt tcgtttgactaaagataaat
4501 tataaatgac ctaatccatg gtaatattat aagaacgact gcttaactggaggcttaaca
4561 agattttctg acaaacggtt tttcaaagtt gtgctcaagt aacttcagtgaaagattgtg
4621 attttacctc tgccaaatga cctttcacaa ataagtggat ttggaaagaacaaatttaag
4681 ttggcagaag cgttatactt cctctgactt ctgagcatat attgtttcacctttcaccag
4741 ttacattatt ccttgtagat gtgcatttta taaatactat atgggtctaccttttgttac
4801 aaacacatat ttgtatgtac agatttgtat aaattgtgga ttaagttatcattgattttt
4861 ctcattagaa aaaacagata tagcagagaa ctttaaacaa ggagagatgctgatgagttt
4921 gagttatagt gtaattataa aatttactat aaatatttta ggtttgtgtaattgtttttc
4981 tgaaacttac tagtgtaaat ttttggggtg gcttctttcc tcggttgattaatttttttt
5041 ttcagagttt atgtttaacc atgagaaagc agagactgtt tttatttaatttgctttatt
5101 gggcatccat catggaatta atcaaattgt acattaaatg ctttgtcagtggattagtac
5161 tgtttcctta tactgctcgc gccctagtgg ctttcaggtg ttaggagttatccacgatag
5221 ttttttttcc aattttgaaa tccaaaaact cattttcttt ttctttctttcctttttttt
5281 tttttttttg agacagggtc atgctctatt gcccaggctg gagtgcagtggcatgatgtt
5341 ggctcactgc aacctctgcc tcgtgggttc aagcgattct cgtgcctcagcctcccaagt
5401 agctggaatt acaggcatgt gccactagag caggctaatt tttgtatttttcatagagag
5461 agggttttgt cttgtaggcg aagctggttt caaactcctg acttcaggtgatccacttga
5521 tctcctaaag tgctgggatt acaggcatga gccactgcgc ccggccccaaaagctaattt
5581 tcttaaatta tttggtgcta taatcctgat ctgaactgac ataaggctatttatagtcat
5641 tattatctaa tttaaatatt tctaatcttc actgggaaaa tagtaatgtatttatttaca
5701 tgatgctgcc atcagtcctg cttgtttttg gggtgtgagt attaatatgtctatgcactt
5761 ggtttccaga aaaattccag gttcagagac tcttgcagtc tccaggcattttggataagc
5821 agatggattg tagccctgtt ccacaggcct tcctccattg ctttattgccttggggctgc
5881 ctggaagagg cagggaaagg taatccagga attcaagaaa gaagccatgtggatgctcct
5941 aattcctttt tacccattag taccaggttt atttgctctt taatctacttcaactcatgt
6001 taatcagttc ttactagtgg cagcttcagt tctaagcagg aaattacagttcagtgtgtg
6061 atgcaaaaaa tgtagagtga gtgatcttgt ctataacaag cttataatcattttggagaa
6121 aataaattta ctcattaaaa atactacaag tgaattaaac tataaatccagaccatgtaa
6181 gtggttttgt aagagagtct tgtgagttac caccagttgt tggctagccttctgggagtt
6241 gcatgggcag gcctgggaaa ggtggaatga tatgagaccc aatgttaaaaatgagtagat
6301 gctaattaca gaaatggggg agagagggat gttttgaata ttgaagaatgacagcaaagt
6361 acagaggaag taaaggtcag ggatatttgg ggaactagaa gcaaaccctttggtgcaaaa
6421 gtcaagagct ttaagggaaa ctgaagggag catggtggga agtgtgaaaaccaaagagaa
6481 agtctgagtt tgagttgaaa gcagcaggag ccaatgaaga ttctttagtggtatgctgaa
6541 agtgaggttt ttaaggagct taacctggca ttgttgcaca gaagtgtctaagaaagctga
6601 ccagaagctt ctcagaagct tctcagaagc cattttcaac tgcagggtttcttaaagtgt
6661 ctggcagtga ctctgccttt ctcattacag tggccaccca tatatggtattcgaactcct
6721 ctatatgctc ctgattgctg gcgatgatag tggtgattac ttttgacttactgtaggcac
6781 ccatcattgt gctatctgga tacatttaca aaagtataga aatagacatctctgccatta
6841 tggtttgcat tccaaacgaa gcaagcagtg taaacagtgg tcatgcttagatacacatac
6901 acagaacccc ccacacacat attcatgcat acaccgctta atagttcttcagactgccaa
6961 gtgtgactta cgtgttcttt cttgcatggt taagaatttg tagacagttcattgaaatag
7021 aatatttaga caatcagaag tgtacaagat tagaatctct atatttgcacacacatttat
7081 ttgtaggtca gtgggcaatt gaaaaaaaag agaaggagag aaccctaaagtgtcctggaa
7141 attcctgctt tttaaaatct gctaaaaatg agaccagaaa ggtgggagtggggatgtgag
7201 gaggtgggta aactaccaaa taaacaatat aaatactttg gctgttcttataaaaggttt
7261 ttttaaatat ggtggaataa tttactcaaa ctcaagagat gccacctactagagaaagga
7321 catactgaaa gaggaaatat tcaaatgcac aactttgtgt aaaaggtaatacttacaagt
7381 ttaaaagact cacttctaaa gaagtttggc ttcaacctgt cctcatttggacaggtggaa
7441 agatgtatat tttggggtag accagaaaga tgtggtttga cttctatagttgaaaggttt
7501 ctatttagac atttattttg taatttaatt tacctaaaac ttcatccctaaattaccatt
7561 ttctcttact tttatgcaat agtaaagtat gcagtcataa gtgataaaggctgggatcaa
7621 agctagctat tttgctaact gcagaaccta tgcactctgt ttacactgcctgtgatagcg
7681 cctggaagaa ctcactgcca atatttctgc ttgtttcagt cacataactgttgcttgtgt
7741 cagtgacgta acttgtttag agatgcagtg cagtggataa gagcacagggtatggacatg
7801 cctttctgta ttcatgtcct gaggatgcct cttagtacct gtgtgaccttggacaagtta
7861 cttagtttct ctctgcttct ttgtagcaca atgagtagat gctaatttttaatttttaat
7921 tttttctttt tctttgtgtc tgttttgtgt atttagttac tttatctttttttttttttt
7981 tttttttttg agacagactc tggctctgta gcccaggctg gatggaatgcagtggtgcta
8041 tctcagctca ctgcaagctc cgcctcccag gttcacgcca ttctcctgcctcagcctcct
8101 gagtagctgg aactacaggt gcccaccacc acacccagct aattttttttttatattttt
8161 ttagtagaga cggggtttga ccatgttagc cagaatggtc tcaatctcctgacctcgtga
8221 tctgcccgcc tcggcctccc aaagtgctgg gattacaggt gtgaaccaccacgcccagcc
8281 tagttacttt atccttttaa aagtcctctt ccaaaatgta gaatataattaatgcctgct
8341 taatcaggtt gttttgagga taagaatgtg tatataggcc aggtgtggtggctcacgtct
8401 gtaatcccag cactttggga gtctgagtca ggtagatcac ttgaacccaggagtttgaga
8461 ccagcctgag caacatgggg aaaaccctat ctctacaaaa aatagaaaaattaactgggc
8521 atggtgacac gtgcctgtat tcacagctac tctggaggct gaggtgagaagatggcttga
8581 gcccaggagg cggaggttgc agtgagtgag ctgagatcac cccactgcactccagcctgg
8641 gcaacagagt gagactctgt ttcaaaaaaa aaaaaaaaaa aacagcatgtgcatacatat
8701 aaagcccttg gaaccatgat tggcatatag taagctttct gtaaatttgtgttaaataga
8761 tagtcttcat gatcagaaaa caaacaaaga atatagcatg taagtactatgtcctagaca
8821 tatgacataa ctgtgattct tcagcacctt gcaactaatt tattaaatttttaaaattat
8881 aaattactga caattttccc aatttctaaa atatagcaag aggatataatactgatgttt
8941 gattttgaaa caggtgaagg aaatgcaggg tgtttaatca ttcagtgtctggaggctaca
9001 tactgtagtt ctgcctataa tatgttccca cttcccctgg gtgccggggtttgttcctct
9061 cctggagggc agcacaggtg tccatagacc acaccaaacc aaagaatctgggatgatgct
9121 gtctccttat gtgcttcatt catacttagg tcatttggct gtaaaggattttggtacaca
9181 taagcttttt ataatgccat ataatttaat atgaactcat cttgaatatattcagagcat
9241 atacattttc aagtttaaat gtttattaat gaaacatgct aatgttgctactttgatgtg
9301 taaatatctc atctatatta ttgccacaaa aaataaatat gcattctaaatttacaatga
9361 aatcatcaca gaatacctaa aatatcaaca atttcactga ggaaaatataaagaaaactt
9421 aaggggagaa tgctatatgc cagagttaaa cttgtgtgaa tttgtttaggaaaatgtgat
9481 tgcactgttc ctaagggacc ctcttccaga atggtaacta gtacagcgtgtgctgtctga
9541 gatgtgcgga cactgggaca ctgggatgaa ttatggagta gatactttccttctctgaga
9601 gtaagctgat ttgcttgagt actctagttt attccaaata gttgattttgtttggtggtt
9661 ctctttgtca atttgccagt cagtgctgtg acttgcgtgg ttaccctgtgctgaagacta
9721 cagtgctggg ggcattggag gcccgtgagc agacaggaaa aagggaggaaaaatcagtgg
9781 tggacacact tcccagctct tgaacagctg acagcatatt tttttgattcagtaacatcc
9841 agaaagtatt cacttcccta ggattccagt gcagatgtta gttggagtattttagaactt
9901 ttgaccagat accacatttt taaacagaat tttttttctg actggaactggaacaaagca
9961 ctaaacacta aatagaccct caggtagtat gtaagtacat taaaaattagataatactat
10021 attattcatt cacatctcta tggagatact gtatcatctt tttaaaagcaattttcgtat
10081 taatatttgt atttcagaat tagaattgta tgtaagcata taataaaatgaagctttata
10141 gttcagtgct attatgtttt cccaattata gaattcaaat taacattttaatgtgatttt
10201 cttcatagta atttttcatt gtcacactaa tttatttttc tctcaacttttttttattta
10261 aaaatttttt ttttttttaa tttgagacag gcctcactct atttcccaggctgcagtgca
10321 gtggcatgaa cgtggctcgt tgcagcctcc gcctcctgta ctcaagtgatccacctacct
10381 cagcttccca agtagctggg atcacaggca cgtgccaccc cacccagctattttttaaaa
10441 ttttttgtag aaatgaggtc tcactaagtt gcccaggctg ctctcaaactcctgggctca
10501 agtgatctgc cttggcctcc caaagtgctg ggattacagg catgagccgctgttccagcc
10561 taatttcttt ttctcttaca agtgctttgc ttacattttt attgttagaaacaggattca
10621 aataactgct tatttaatat tctttttatg tagaagaaac agtcttgaacttgataatac
10681 ttttggttcc aacttgttaa aatattggaa aaggatgaaa catttgtgaaaataatcaga
10741 ccttggcact gcggtagttg aggaagagtc atgcgtgtga gtgagtgccactctgagaca
10801 ggcagcactt tctcccttgt ggtaattgaa tagggtatgg gaagccgactacttaatctg
10861 cttcaggcaa gcagtgttca aagtttaacg cccttttact gaaatgacaaacataatcac
10921 cttacctaaa aggatgtgtg ggtaatgatt ttaccaaata gttcacttggtgaacaatag
10981 tgaaaacagt tcaccttccc ttgtctttgt ttacaattaa atgagcccctccaggtccct
11041 ccctgcccca agagtggatg aatttggcaa atcagactga aatgttaaagaaaatggtct
11101 tgactactct gttttaactg aagtgaccac acagctgcca tgaatcctgtgattgaattc
11161 ctataacctg taaaagggat tgttatttcc actcactcca aatttcttggaagtagctag
11221 ttgatatcag ataccagatg cgaggctatt ttaaatcact gtgatttaatttactataat
11281 atcattgcct acatggaata tttttaattc tttctttttg tttgtgtctgttttgtgtat
11341 ttagttactt tatcctttta aaagtcctct tccaagttta tgttttgaaaaaagagaaca
11401 cttactgaga ttcatgtttg cttacaggtc atgacattta tgacttccctaaaaaacaaa
11461 ctgatccctt tgtctcagag ccaaatttta gttttaacat aatagtgattcattgtttgt
11521 tctctctgag tcctagatct ctcttttaat tttggtgtct gtccatgccaaattagaatt
11581 ttattaaggc caaaattatt catgagtcat gaccatcaca cttaacaattgggtaatttg
11641 aagctgcttc agatacacat taaagcaaat aatgatgtca taaattttaatgcaatattt
11701 tttttccttt aatattggta gcagtgaagc ctgctctgtt agagaccaattctgttttac
11761 tttagaaaaa tgtacctttg tgctcatgtc catgagagca cagtgtagttattttattac
11821 tataatatag cacacagtga cacataactt agtaaattaa agattgaaaatatttaaaat
11881 tggtgatttt ttgtgccatg ttgatttgac atttattctt ctatctgtctaaaactagga
11941 gcagtgctag tgtgacagcc tcaagtcatg ttaacacgac acacgtagaagactgacgct
12001 cgggcttcct ctagtgcaaa acacctgaaa ttcaaatttt gcttttctgtgctattttcc
12061 taattaaatg tatccttgat gttgagttta actttattac acccctgttaaatatctgca
12121 atgtgttggg aaggaggagg acacatatgc ctgatttaaa tttaatataactgtatagat
12181 ataatttcat tttccattca atcattgaaa tgatataaat taatatatgtacagctaaaa
12241 ttaaatctgt gatgtcgaga tgaactccat gctgtccttg gtgcactgtgtattacacat
12301 gggtattaaa tgcgtgctta gtgcttagtg aatgggttag aaggagtttttttttttttt
12361 ttttgagatg gagtctcgct ctgtcgccca ggctggagtg cagtggggtaatctcggctc
12421 actgcaacct ccgcctcccg ggttcaagca attctccctg cttcagccttctgagtagct
12481 gggattacag gcacgcacca ccatgccagg ctaatttttg tattatttagtagagactgg
12541 gtttcaccct gttggccagg ctggtcttga acacctgacc tcaggtgacctgcccgcctc
12601 tgcctcccaa agtgttggga ttacaggcgt gagccaccac acctggcctagaaaagagtt
12661 ttaatagata cccctgtaaa atgccaagca atcagttgcc attactaagaactgcaacaa
12721 gttccagtta aagatgtaca tgtttaagag ctgtcgttct ttaataaaatatgaccaaga
12781 tgtcttaaac atgggcttta atacatgtta ctgtgggttt cactccaacttaatagcaca
12841 caaagttctg aagacacatg atttcactgg tggtacattc gcacattgttttctgtccat
12901 gtttaagttc attcttgtcc agaacagttt ctggttttct aagcctaacgtattaacatt
12961 tgagttaatt aaatcgatag ggagcctttt atcttttttt ttttcctatctgggggcttt
13021 gctttcgcac tgacattagc agttcccttc ctatgtgcaa taggaaaatgtgcagtcatt
13081 ccaggagcat ggtctcctca ggaggttaaa agtgattgta acttagaggttaatgtttca
13141 ctccagagga aagtgtttca ccccacttga tgatgtgccc ctgggtgctcacagaaagag
13201 tagtactctt ttttaaacca aaattttaga cacgtgttat gcaaatcttctttataaatt
13261 acacattctt ttctttcctt ttattctttt actccagtat actattttgcaattaaaaca
13321 ttttaaactt cttccagaaa aaaacttctt ccaataactt cttacttcaaactactttta
13381 ctaatgacaa aataactatg tccatcacag tgaggaatta ttcattgtttataccacctt
13441 gtattactta tataaatatc atcctataaa aaatactata tattgggactagattttctt
13501 aaatttaaat ttaaattctt ttggaaaatc aggttctatc agctctgttgtcttttcatc
13561 tctaattgta catcttccca ctattttgat ttatacatga tgttattatattaggatagc
13621 tttgatttta atgtaatatt agctagtttt atggcttgaa aaacttagtacatagactat
13681 attcataaat acagcactat acattctagc atatggcgtg tgcacttaatctgaagaatt
13741 agacattttt tcctgttctg tgatgattga ttgattggtg gtgggggcagaaggtggcca
13801 gtctttggca acatgtaaaa ttttgttaaa attttgtcaa actgatttattccattgcta
13861 aattttgaaa tcagcatttt tttaggggga atatctcgag tttatgaggacagaaagaaa
13921 tattcttaga aaattgagaa ggttttgtcc ctgtacatgc aaactagggggtgtttagat
13981 cagagcaaat gtcttgcagc aggggttgac gccgggccat gtttagtcatcaaagcatga
14041 cttctattct gggaatgtgg taattgagag gtaaatatta tttacaatagcccttataaa
14101 tctttagttg ttcaacaaaa taacttgcca tcagagttag atgatttagctaaaattatt
14161 taattgggtt attcctactt gatccaacat ttgattataa tatatgtagtagcgttaaat
14221 aatttgggat ttctggcctc tggctggctg ttgaagactt tttgttggtggcggggggca
14281 tcctaaggaa caacttgccc tctactagca ttctttacta gaaaaagctcctatttactt
14341 gttttttttt tcctaaatat gtgttttatt tccttttggc attgtctttcttgctcccaa
14401 ttataattgt gagcaaatag caatcgaaat tctgtgtaac ttccagcacagtttagtcat
14461 cagagcttgc cagcaagtat gtctattgtg aggaaactgc atttgccacagctagaccat
14521 cagcaagtga agtcgtattg tcctctgttt tgtagttgtt ttttcctatttatgctttac
14581 tctgattcaa gttcagcatc tcagtgatca taattgtggg gaaaaaaattcattttgaac
14641 tataaacaga aaagatacca agttgttgta tttgaaagat tattttagaatgtggttata
14701 ccttcaagta aaataagctg taaaataagc tgaagaacca tatatttaggcacattttga
14761 ctataaaata gatcctctac atataacaag aatagctttt tttttttttttttttttttt
14821 tttttttgag acaaagtctt gctctgtcgc ccaggctgga gtgcagtggcacaatcttgg
14881 ctcactgcaa gctccacctc ctgggttcat gccattctcc tgccccagcctcccgagtag
14941 cagggactac gggtgcccac caccatgccc agctaagttt ttgtatttttaatagagaca
15001 gggtttcaat gttaaccagg atggtctcga tctcctgacc ttgtgatccgcctgcctcgg
15061 cctcccaaag tgctgggatt acaggtgtga gccacggagc ctggcctatatataacaaga
15121 attgctttta tatgtctata tgtcacttca taatatttgt ttattatttagctagttatt
15181 gcctataagc cagtatttag gtattatata aaatctgagg aaaacagttctataagattc
15241 agtaaaattc caattctata agattccaag atgtaaagtg ttttaggtatttaaaagttt
15301 tatatagaca atagtgactc atttgttatg gtatatgaat atagacaagaacttagactg
15361 aagcaaaaaa taacaattag ttacatagct atttcaaagc ccatgcagtagttttttgtt
15421 tgtttgtttg agacggagtc tcgctgtctc ggccaggctg gagtgcagtggtgcgatctc
15481 ggctcactgc aagctccgcc tcctgggttc aagccattgt cctgcctcagcctcctgagt
15541 agctgggact acaggcgccc gccaccacgc ccggctaatt ttttgtatttttttttagta
15601 gagatggggt ttcaccatgt tagccaggat ggtctggatc tcctgaccttgtgatccacc
15661 cacctcggcc tcccaaagtg ctgggattac aggcgtgagc taccgcacccggccagtagt
15721 ttttaatgtt cagtgaagtt aaaacatctc ccgtccagtt atgctgtgtaataaatatta
15781 aagcaggaga tattagaaca atacaacact tactgtgcta tttataatttaaaatattaa
15841 agataaataa tggaataact ataaatattg atactatgat aaaacttttagcatgtctaa
15901 gttgttcatt ttgatagata caaaaaacca aagccaagca aaataaaacacacctaaaac
15961 tttatgaatg ttaacaattt tctatttttg ccataaatct ttggccgttgcaccatattt
16021 tattgaataa aggacagttg ttaagctagg gcttggtcca ctgtgtgtcagtatcaggat
16081 gtgatgattc ttttctgacc catattcttc tctctctttg gctttggttctcttgtacga
16141 ctcttctgta ggtggccttg gccacacctg tgaaatatag ggcacagttgtgctgcttct
16201 actcattgtg aacttgatca tatgttttgt attgtgcctc tcttcattggctccttttta
16261 ttttagtgta attcaaagtg ttaattggag gttttaaatg tagttttgaccaaattgtgt
16321 ttgaggtcac atgtacccag tttaaaaaac gaagaaaaaa attcaactcacttcccagcg
16381 tcctttgcag ctaatgttgc cctcgaatag ttcttgctca taagagaaaatctagcaggg
16441 atttatggga aaacttttgc ttttttttgc taaggcactg cttttcttcttgttccctta
16501 tttccttcca tggaaatcag aaaatgtttt ataattttaa aactttacctttgtttctca
16561 aaataacact ttcagactta tgtaaagcaa gattttaata attaatatgttgcctcgatt
16621 atggagtaac tttccaaagt tgtactatca tgatcttaat ttattgacccttagggttaa
16681 gataatttgt gtgtttataa cctaacattc tttgcttggc tgatagattcctttaaaatg
16741 ttatgtgttt atattttgta catactttaa gaagctttat tcaattgccacatttcaaat
16801 aaataaaggt tctttttttt ttggtaagcc tatacctttg tttcttctagcttttaaaag
16861 tgttaatagc gtgggaatga cccttgacca tctctgattg tttgggaaatggtaactaga
16921 aagaactgag agaggacaaa cttggatgag aagtctcaga actgatagtaaaaacaaatg
16981 caaacaagaa aatatattac gtacttcatt cagattaata agtaattaaacacttgaact
17041 attcaaaaat ctagtttgag tctaggcttt tgcaagcctg aatttgtcatcataatcatc
17101 aaaattagaa attacgaaag aatgttaatt taaatttaaa acagctggaaatacaataca
17161 tggcctataa gcttatcttc tcatctgtca acaactgctt gcatatgtcacatgaactgt
17221 tttaactgca attacaaaag tcaatggaat gtttagaggt gattcaaaaaatgtgattgg
17281 ctgacatata gagttatcct aagaaacagg ctgtccaaca caattttaaatatactcaag
17341 ctcttttata ctgattaaga gtttcaagtt aaggttttgg gttaaaaaatcaacatcaaa
17401 tgataaataa gaaatataat cttgtttaaa ttatttattc taatagtttatttatgaaca
17461 caacatattt ctctttcatt actttttttt tctcagttgt aaaattctagagctggagcc
17521 cataggccaa tccgtagtat atctgaaatg attaaaggtt ttatacttgacaagccctct
17581 gtctgcaggt tacttgcttc tacttggagc agtggattta tcatcctccactccagggta
17641 aatatctaaa agtcacttct gccacgttat ttcccatctg gtagattgttataatacctg
17701 tgagtcagta ttatctgcac agtgtatttc ctctgctcaa ggcactttgaccatatgagg
17761 tgttcacatc tgatcaatcg ggctgaagct tgccctagtc tgaggctggaccaattgatc
17821 tctaacgata ttcttacctg acaatctaga ggatacaaat caagatgtttcaagtgcaga
17881 aagcaacagt aaagcataag ttcttttttt ttttttgcat tctttttttttttattatta
17941 tactttaagt tttagggtac atgtgcacaa tgtgcaggtt agttacatatgtatacaagt
18001 gccatgctgg tgcgctgcac ccactaacaa gcatatgttc taatgtgtaatatatcttca
18061 agacagtctg gaccatgaag tgtattttta cttattgagt gtatatgggaggatcatttt
18121 ataggattgg ttatattttt ccatttcttg attctttgat acttaaatttttggtttcat
18181 attctcctct ttcacatgtt gtccccattt tacatatgca aagatagttgtttgccacaa
18241 aaataaacat ttaacagact ccaaacacat agactgtgta attagcataacgaaataata
18301 gtggctgagt gacgagcaga agtgattcac tcatttggct ctgtggctttcaaagttatt
18361 aatgatgtta catattcttc tctattttat ttaaaaacta acactcataaagttaattct
18421 cataattttt gctgggttta ataattcaaa atatgaatca aaatttttatttattatgca
18481 gtttcattct attaaaatta tctgctaaat taatattaag tagtcctatagcatatatta
18541 tttaataatt gcaagtagtg acatatcata aataaactgt ataatatgtattattgattc
18601 tgttattttt cctagcaatg cacagggaac cagtaaattt cacaagcagagaatactaac
18661 ttgtcattta tttaatattc taaacaaatg aagccgcctc tataagtgaattttctggac
18721 ttctaaagat gagcattgtt gagtttaata actcaaattt ttattgtgttaagtaaagta
18781 tattaaatat aacctcaccc taatgactca gctgtaatta aaaaagagttcacgaccagc
18841 ctgggtaaca cggtgagacc ccatctctac aaaaataaaa aataaaaatgaaaattaaaa
18901 aaaattagcc aggcatggtg gcatataccc aagtactccg aaggccgagggtggaggatc
18961 gctcaaacct aggagtccaa ggctgtagtg acctgtgata gtgccactgtactccagcct
19021 gggaaacaga gcaagaccct gtctcttaaa aaacaacaac aaacctacacatgaaaatta
19081 ttgctgcttc ccatcaattt tcagtgctat ctttatttaa cctctctactatttgccttc
19141 actttttaaa attttgcttt tattcttctt tctttggtct ccttctctaaaatttttccc
19201 ctgcttctgt ttttttgtat actaggaaga catttattat ttttataggtatgatcaaat
19261 tgtaaaataa gtttatttca ttctctggtg atttcactaa ctattttgagagtatcagtt
19321 aaaatgggat ttgtttgtgt gtaacaaaat ctaactgtag tggctaaagcaaattggagt
19381 ttatttttct ctagtaacta aaaggcccca gtgggcgttt aagggctggtaccacatgga
19441 gcaacatcat atcatcaatg tccagactcc tgtgcttttt tcacttgatcatttttagag
19501 tttggccttc tgtgcttcat tcctcgtggt cacaacatgg ctgattgttgtgcagcttta
19561 tgtctgattt caaggaagaa agaatagtga gagaggaggt tgttgccttaacacattcaa
19621 accaaagcaa aagttttctc tgaaatcccc agtagatttg cccttacatcttctcaggta
19681 gaagtgcatt tttgccattc ctggctgtaa gagaagccga taaagaaaatacatgcactt
19741 tctaacaata ttgaaattct tttcacaaag aaggaaagga gaatgaatgtactttgggta
19801 ggtatcgtgg tctgttttat gttgctgtaa atcacaaact ggatgatttataataaaaag
19861 aaattagttt tcctcacaat tctgaagact ggaaagtcca gggttgcagggctgtgtctg
19921 gtgagggcct tcttactgtg tcttctcatg gtggaaggca tcacatcaggagagatttct
19981 ccagagtgca agaacaggtg gaactttata taacaaactc attcctgtgataaggagccc
20041 actcccaaga taataccatt aatccattca ggtgggcaga gcctcatgacctaatcacct
20101 tctgaaggtc ccacctttca atgcttttgc attggggatt aaatttccaacacatgaagt
20161 ttggggaaca cattcacgct gtagcaggag gcaaccacat ttgtgacattgcgtcattgt
20221 actttctaga tttgttttct ccaggttgtt tgcaacgttg atgtactctttgtataccca
20281 cctgaaagat taatgttact gaagtattgt gtttaagaaa gaaagatgaatgctaccatg
20341 taagaccttt tgactgtcca aaagattaaa attccagttt ggagaggtagcacttacatg
20401 aaaaccttat aaaacatgag aacttaaact tgctaatttc attgtgtcaaatcgcataac
20461 agagaaagga aaaacttgaa ggccactcct cttgaaaaag tatttgagtagtgtcgattt
20521 cagtgtaaga ccaattaaat aatgtcaaat taagtaaata taacattaaaatattttctt
20581 taacatattg gtgttgattt cacttttact ctgtaatttt tgtgacattggaaacaggaa
20641 atattcaaat tttgccttct tttggatcgt ttcctctccg tttcttaatgtgtaaaccgt
20701 aatagggctt tctgcagcca acgtgctcat tcttttcttt ctgttaggctgtgccttttc
20761 tgagaacagt tggtactgat ggagatttct gttctttttc ttcacacaagtgtcatatga
20821 aaattggggg atcagctatt ttcagatcac aggctcctct gataacagaataccataatt
20881 ccaactttcc tgtgttgatt tgtagatccc acactgtgtg atcatgacaaacatctaagc
20941 ataagagggc gatgaatgat taaaatttat tcactcttcc cataaaacacctggtacaga
21001 tgcagtgtgt tgtcctcaca gaggaaaaac agtggttcct ccttccaagtggcgtgtcca
21061 cagcactggt accagataac aagaacctta gacttttctt gttgctgcagtgtgtctacc
21121 tgtgcctctc ttaagtgtct tacacgttac tcacagagaa agaaatacaaaaatggaaaa
21181 cataagctca caaaaatgca tttagtgcat ttatgatgtt aatggaaaccttggatacag
21241 tcctctgtta tttccttact actcttgata ttttacaata ttgctttattattcaaattc
21301 ataatcatat atgtgttaaa caattttttt tggtaagtag actgtgtatcaaacttaaga
21361 gggatttgac atggaaagac atttaaaaga tggcagaaaa cagctattataagggcattt
21421 gaactttaga tattttccgt tggtcagttt ccatagatca tcatctgattcactagggtt
21481 tggccagttt atattattta aattgtttcc cctgcaactg tagtattttctttaatgttt
21541 tgaattattc ttaatgtgac ttgaataagg gtaattgtca catatgctgatgttttccca
21601 ttaggatgaa aatatttaga aaagctgtac tagcaaaaac caggttaacttgttttcaaa
21661 gtagaattta attattttat ttcaagcttt gattcctttt ttaaaaattaagtaaatgtc
21721 cttgagagca atacctttgt gtgtgtgtgt gtgtgtgtgt gtgtgtatcagttacttgca
21781 ccttcaattg aatgaaagac agtagtaggt tgtattatgg cagaggggtagaagaatgga
21841 cattctcatg ggtatctcaa aggtcaagtc agaattggat tccctgtggatggaagagag
21901 gagtggagaa ggtgcttctc atgtggaaaa acaagaaaag tctatgacaggcctcagtgt
21961 ttgccagctg cagtggaatt ctcatagctt gtattgaact ctgtgtcctaatcttctgaa
22021 accacctcaa gagagtatat attgctaaaa taggagctca gctatttttcaggggcagtg
22081 atccagagga cactataaca gaaatagata atttcaaagt cgaaaatatattagatacta
22141 tttttattct ctatctggaa agtctgtata gaggctttat tctggtctgctttctcagat
22201 aaatatccta ttcaggtcac tggaaataat atgtcaggtt ttaaaagagacttcatatgt
22261 agccaaataa acctgctaag catatttaga aaatcatgct agtgactagtgtcttaaact
22321 gtttccacaa aaacaatgct gttaatagta ggatttaccc ttttgcattggaaatgagtt
22381 gtcaaggtta aaaagatgag tagccagata ttcttgctaa acatgttttgagaagaaatt
22441 taataatata aagtttttgt taaatgtggc ctattaattt taaacaataatactgactga
22501 agtcattagg tagctgtgga aagaagttag cctggttttt actaatgtagcttttctaaa
22561 tattttctgc ctaatgagaa aagagggata agatccaact acaattggaagcttaaatat
22621 ttaatcaagt ttgcagaact actattaaga tcatatgtaa ctatcagatattttttaatc
22681 tgaggacttc tttctagtaa atagaaattt cttcccaagc attataggaatatgtcttat
22741 tgacttattt ttttggcatg ggttactagg aaataatatt ttcagggagttcagggaccc
22801 agatttgatt cccagataat tcagattaac cttctttaat cattctattttatgttatta
22861 ctggagagta cagggtaggt tgaaacagca taaactgcca aatcagaactggatttgaat
22921 ttagtgatgg gcctcaggag ctgtatgacc ttaattctgt gagtcaggctttctgagtca
22981 ggctgtgaac tgggcaaaat agtgtatacg ttacaacatt gtaacagagctcatttaaag
23041 cattgtctca tgttagctac tgataaagca ttagttccca ctccagggcctgttagaatt
23101 ctaactccat ccctgtgagt catgttcatg ctttcgtggt tctcatttgaggttttgtga
23161 ccaaaggccc cacagatgga ataaaattaa tctaaatagc catttattaatgtaatatct
23221 gctagctaat tacatattta ttaaatataa ataacaaata gctccaagataccagtgacc
23281 tccatgttgc taaagccaac agttattaga acttctctgt tctgtgagcttttctgtgat
23341 ggtcacaggt gagaccgcaa gaggacacac aggagaggca caatgaaacaaagtttatta
23401 tactcatagg tcttagacag gaggtcaccg catgccacac agggtcacagggtgtcttag
23461 tttgttcagc ctgctataac aaagtgtctt agactggata atttataaagaacagaaaat
23521 tcattgttca tagttctgga ggttgggaag tccaagatca aggagccagcagattgggca
23581 tctgctgagg gcccactctt catagatggt gccttgttgc acgtccccctcacatggtga
23641 taggggtaag gaggaagcag gctctcccaa gcctctttta taagggtaccaatttattct
23701 tgagggctcc accctcatga cctcatcatc tcccaaaggt ctggcctcttaataccaaaa
23761 cgctggggtt gatattttaa catgtgaatt ttggagggac attgacattacagaccacag
23821 cacggggggt ggggggtggt tctccatgtg gcagaagaca ggaaagaggagagagcttat
23881 gccacagcct ttactggagt ttcagggtaa aggcaaggca gagtagagtagggtaaacag
23941 tttagaactg gctggtttga atactttcag taggctctaa ggtataggattaatccctag
24001 ttgcttgata cctgacagtg ggaaattaag gcagaggaat attgtctcctggggtatata
24061 gccagataaa ggaggtatgg ctctggattg ggtaatttgc ataccaaaggtgttctccct
24121 gctgaggttt ttgctgtctg taaggattgg cagcccctgg agggccatctctcccaagcc
24181 ataaactttt ttttaagatg tcgaaatatc atagtactca gaaaaatttgaaatatatat
24241 atatatatat atatgtataa aacatcctct tacttggcag catttacaatgtttgatcat
24301 tatttttcag ctttgtcttc aatgcactca ttttacctca gtggtggttactccatccca
24361 ttctccactg ctggctactc tccttgaact tttaatgtcg aagtgttcagggctcagccc
24421 actgtcctct attatttttc atttctattc actctcttag tgatttaacccagtcccatg
24481 gttctagata tcttcatatc tgtatcttta gtccaaatct gtcttcttaactttaaaata
24541 taactagctg cctttgtcat ttccactcag atggctaaca gacacttcaaatttaaacat
24601 tcccagttga aatttttatc tctccgtttc tgatcaaatt tgctctagctctacctatag
24661 ccttccctaa ctcagtcagt ggcaacaaat tgctccgagt tggtcaagtcaaaattcatg
24721 gtatcatcct tgacttcttt ctttcctacc ctacattcag actcatcagggaatccaatc
24781 ctcttggctg tgtcttcaaa aatataacca gagtctaacc acttgctacatctctgacct
24841 gagccaccat cgtcttccac ttggatcagg gcagcgttct gtttaccagtctcactggtt
24901 cttatcttca cctccctaga gtgtattctc aactgagcag aaagaagaatccttttagga
24961 tgtaagtcac attatattcc tctcctgtta tatgtaaggc cctagaatagttccctactt
25021 cacaaaaagt aaaaaccaaa atctctatca agtaatagta gtcattgccctggcagtgtt
25081 tcaattaaaa gagtttaacg actggttcat tttatagagg tgtggacagtgtcaaggaaa
25141 cagaaaagaa caaaagaaca tgaagcatcc aggtactatc aacagtgggaagtcctaact
25201 accctagtcc tgcaggggca aggtgagcga atagtgctat cagccctggaaattgctggg
25261 cactgtagga gaggggctgt caatagaagc tctaactgta gagtgcacacacttctctca
25321 ctatggtgag gcaccataaa tgtggtgagg cagagggaga gtgaggagaatgaatatcca
25381 acctattttt tcttcacatc ccagccaaat acttggcatt gttagtcttttttattttag
25441 ctattgtggt ggtgatgtaa tagcatccca ttgtggtttt attttgccttttcatggaaa
25501 ctgatgaagt tggacatctt ttgacaagct tgttgcccat ttggatatcctcttttataa
25561 aatgcctgtt taagtgtttt gttcattttt ctttttggtt gttttttttttttttttttt
25621 ttagatttct acaattcctt tacatgattt ggttgccagg ctttttaaagctgtgtgtat
25681 tgcagatatc ttcttccatc tcttactggt cttttttctt tctttctttcttttttttta
25741 ctggccagat ttctttaatt ttaatgtaag gtgatttttt cttgtttttcctctatgatt
25801 aatatttttt atgtcttgtt taagaaacat ttgtctatcc aatgttatgaaaatagtctt
25861 gtagaagctt tattgctttt tcactttcag atttatattt acgatcaacctggaattgat
25921 atttgtgtag tggggagggt agaaatcaag actagttatt tttaatttggataactaggt
25981 aacctagcat atttctctgc tgctctgtag cattaccctt gtaaataaatcatgtctcta
26041 tacggtttct ttctggactc tgttttacga ttgtatgctc tctggcattagtatcacact
26101 gcctgaaatt ctgaagttcc atagtatctt ttcttttcct tgtttttttttttttttttg
26161 agacagagtg tcattctgtc acacaggctg aagtgcaata gtgcaataatggctcaccac
26221 agccacaatc tctcagggtc cagcagtcct cccacctcag tctcctgagtacctgggact
26281 acaggtactc accactacac ttggctaatt tttgtgttct tctgtagagataaggcttca
26341 ctatgttgcc cagactggcc ttgaactcct gggttcaatt gatcctcctgcatcagcctc
26401 tgaaagtgct gggattatag ctgtgagcca ccatgcacag cttcattgtaccttaatatt
26461 tgacagaaat acctacagtt tgttctttaa tatcaccttg aatatagatattgagattcc
26521 attgaatcta aaaattgatt tggggaaaac tgatatatta gcaataatgggctttctatt
26581 ttggccttat agcatttatc ctattatata atcattttta agtttttctttttgtgtaga
26641 gaccttgcat atcttccttt tcggtaccta ggtatgagac attttggaagctatggcaaa
26701 ggatatttgt ttttgcattt cattgtcttt ttttttctgt gtatagtattctaggttggc
26761 atttattttc tatattctaa agattttttt ccatattacc ctctgttttttattacatcc
26821 actatcaatc ttattgttgc ttctttgaac aagaaatgat tttcactgttagcatttaaa
26881 attctgtctt tggggccggg cacggtggct cactcctgta atcccagcactttgggaggc
26941 caaggcaggg ggatcacgag gtcaggagat tgagaccatc ctggctaacacggtgaaacc
27001 ccgtctctac taaaaataca aaaattagcc gggtgtggtg gcgggcacctgtagtccagc
27061 tactcgggag gctgaggcag gagaatggcg tgaacccagg aggcggaggttacagtgagc
27121 cgagatcacg ccactgcact ccagcctggg cgacagagcg agactctgcctcaaaaaaaa
27181 aaaaaaaaaa aaaaattctg tctttggatt tcagtagttc tattatggtgtagtatttta
27241 gatgtagctt tctttgtgtt taatctgttt gatgatcata gcaatttttgaatctacagc
27301 ttgatgcttt ttgttatctt ggaaaatcct agaaaactac ttctttaaatatgccttttt
27361 ctttatagtc tctatcctcc agttaaatat atattaaaca tttgcagtatctgctctata
27421 tctctatgtc acttttccaa tcatctatgt ctattatgct tttttttttctagttttctc
27481 tggatgtttt ctactgatct gtcttccagt tcactaatcc tttctttagctctaatatta
27541 ttaattccat atattgagac ctattttcag ttattacatt ttacagttctcaaatttctg
27601 ttttgtaaaa taaattctat tctttgctca aattcttcat cttcctttctgttttctcaa
27661 acatactagt tgtagtactt taacaatacc tatttctttt ttttgaggcagagtcttgct
27721 atgttgctga aggtggtctt gaatttctgg gctcaagaga tcctcccagttcagcttcct
27781 gagtatacaa tacctatttt aatatcaagc acaactgaag tttcatttttattgtctatt
27841 ttttctattt ttttgttagt cttatttgtg gatatttttc ttatttgctgaaaacttttg
27901 attgaatgtt tgatgtttta tttaaaaatt ataactgtct agactatgcagttttgcctt
27961 tctagagagg attcagtgta tcctctggta atcagccaaa aggcagacagatcactccag
28021 ttccattaga atatgacatg gctagaagct tttctgaagc ctgtgtgtatcagtctggta
28081 tggcctaccc actttccttg ggagttgtct ttcaggatac ccattcagagcctatgaatt
28141 tatgagattt tttttctttg gtgggttctg aacttcaatt tttgtaacctctgcactatg
28201 agactgttgc atacattctt gtgcttttca gaagatattt gcttggcttctttgcttctt
28261 accatggata atttgaaaac ttagtgcctc aaaaggaaaa ccttaagtatcagggaacct
28321 catttctctc ttgttttgtg taccctctgt ccgtgatctt agcccctcaaatctgactgc
28381 ctttaaaggc ccaaacttta atgttttgtc tctccagctc tgtgaaaatgctggcagtct
28441 cacttttgtt aactctgttg ttttctgcct ggattttcag cctcttacctatccaaggac
28501 tatcatatta tattacccaa gggaaaatgt tgctctcata atgtctgctcacctctctta
28561 ctttatgttt ctgcccagga tcttggcaac tgaaagcttg gctgtctctatggttatatc
28621 ttcaaatagg tgtttgttgc ttttcgtttc atctcatatt ttctagttgttctcagtggg
28681 aacattgttt tgtcacaagc tattccatca tggtcagaag tggaagttgctaagtcaact
28741 accttgataa ttattgtgcc gttagtatgg cttagtgact aagggaacacatttttgttt
28801 ggataggcct ttggtttaaa ttcctcttac tatgtttgag ataccgttccattgaaaact
28861 tagttttatc acctgtaatc agaaaaaaaa agaccttttt ttagaggactcttaggagga
28921 ttaattggaa aatattcacc taaagtactg attacaataa ccatcacatagtaaatttag
28981 taaatatgtc tcaaatgata cagaaacctt atggaacctg taaggttaaatcatgcattt
29041 ctgaaagtag taataatatt tactttactt ccagtgggtt aatatgaaccaaattatttg
29101 aagatatttc tattaaatat tgattacgtg aaagaatata acatatacttaagatctata
29161 acaataaatg aatgccagtg taccgctact caagttaaaa ataaaatactaccagtccca
29221 ttgagtttta tgtatatgta ttccttataa atatttcatt gagtttttgcttttgaaatt
29281 tatgtaattg gaatgatgtt ctatgcacct ctttgcaact tgcattattataacttgctt
29341 tatcttaata tcatctctgt gattcattca tgttaactat agttttttttcattttctct
29401 tattttcaat gtggtgagat tatgttgtat aatatctccc aaatatgcatttattattaa
29461 tagaaatggc gtgctttttg atctttcact tttggtcctt tttccttggaattgtatttg
29521 ggaattagtt gaagatgaat ttctctagag cagctttttg tttgcttgtgctccgcacct
29581 gtggacacta taaatagaga ccactttcaa aggtattttt ggcttaagtctgctcgaacc
29641 acacagatag tgttacttca gaccacaact aggatgagag ctttctcctgattatatccc
29701 aaggaggaga tttctttctt ccttttaccc agagcaaatg ttgagacaggcaaatttcct
29761 tgcagtctcc ttctgtagat cagagttatt tttctagttt gcccttatattgagaggaca
29821 ctatagattt gttctagctt aacttaggga actactatta gactctttaagagagctctg
29881 ggctctgttg cctgttaaac tgtcaagttc aaagcccagg ttcaccagctggagcaactg
29941 ttccagggtg aatatgactt agtgttgaat actctctgaa ttatttcactttatttttgc
30001 acccctagga atactttacc ttcttaatag atctttatat gcagacacacatatgtttaa
30061 acatatggaa gtacatatgt gtgcatgtat gtagataaat agatagatgcactttttcag
30121 aaagagtctt ctaccgaact gttagaaaca gaaatgtctt aagtctgatttgtgctgctg
30181 tgacagaata cctaaaactg ggtacatgat gaaaaataga aatctagttttcacagttct
30241 agagattgaa acgttcaaga tcaagttgct ggcaggtcag gagcctggtgagggccccgt
30301 ctctgcttct aaggtggcgc tttgaaggct gcgtcctctg gaggggaggaatgttgctcc
30361 tcacatggca gacggacaga agagcaaaga gatagaaccc atgatacatgaaagcccttt
30421 tgtaaaggca ttaaacccac caatctgggc aaaggcttca tgacctaatcacctcttaaa
30481 ggccccacct ccccccatat tcttacattg gcaattagaa ttcaacatgagttttggagg
30541 ggacattcaa actataccaa gaaataactg attcagtttt tataagaaattttagaactg
30601 tccctaagac ctggtgagtt tcaggcctca tgttctgagc ctacatctgacatcagctac
30661 catagtatcc gctgtgcagg cagagcctct tcagtcatag gtatggggtgaaacagattt
30721 ccacctcttc cctgagcttc gctggcacag aataaatgca ttctaaagaaaactgatacg
30781 tcagagacat ctgagcttac tcttaattgc tttcttacct ttctctgtcttgggccagat
30841 tttcttccag gctgatggct tcttccaact ctgaattcta gcactctctgctgtttcatt
30901 ttgtattcca tgccttcgtc tcttctctga tcccttccat ctgcctgaaagcacttcctt
30961 tttattattt ctgtgtccta taataataaa gttaacaaaa gtgttaagtatatgtttatt
31021 tttccaaggt tacataggca catgtataat gtagggaaac tggctgacaatcagagacag
31081 aagacacata cacgtgggcc cacacacatt cgttcactgt tgtccttaatgcagtattca
31141 acattacaaa ttactgtaat cttaataaaa ctgcgacatt gttttccttgtttatttagg
31201 gagcaccttt aaaaatcatg tatttgctga tttattcatt cactattgtccttaatgtag
31261 tattcaacat tccaaattcc tgtaatctta ataaaactgt gacatagtttccttgtttct
31321 ttatttaggg agcatctata aaactcatta tttactcctc agaaaacttgcatgggcata
31381 tagttatgaa ccagtttgaa tattatgatt ttatattcac aatatttttatacttatgat
31441 cctaggctaa ggatatttat attagaatgt tcgctgagga cttaaataagttctcactga
31501 tacttacact gaatattatc tcaatgtact tgagagaaaa ggtattgcaagtaaaggtaa
31561 atatatgagt acatcaattg tataatttaa ttttctcaca attttaggacaattttgtat
31621 aggatctata atcatatact tttttaaata ttcacttgct tttattaaatcaatcacaag
31681 aaaatacaga acgttttccc cttccacttc tgaagtggag gaaatcacttcaaattcatg
31741 ggatctttga actttgccca ttgggccaga cttgcagtat cataaacttctttttcctac
31801 ctatgtatga ttttgccatg tgcgaaacaa tcattgctag taccacgagtgagtgatgat
31861 aagcttagaa tacatccagc taagatcagt gccatttgaa gctccctcaatatcgcattt
31921 cttcggttct ttaaaaaaaa ttcattgttt tggagtcagc atattattaatgaatggagt
31981 atttgagggg aataaatatg actttggcaa tatcacatgc atgggaaaaattggctagag
32041 aaagggctaa gtctttcatt ctgtgtttta gagaacagct ttagctcgtatgaaaaaatt
32101 ctggcataga tatgtgaggg ggagtgttgg ataagaaaag gaaagagaaaaagcttgctg
32161 tggagtggaa ttctcatcac atttctttct tacctactac tctggggaaacttcagttac
32221 agggctgata aatatttatt aagaatatat agacagtata acctaaaaacattggaagat
32281 attttagcga ggcttgagtc agattaaatc taccaaccgc taaaagatggctttgcctag
32341 agaaattctt ttttctttgg gagcagctat tagggaaaag cctattgcctaatatcttaa
32401 ttgaaaccta tgcataaaat tcaattaaaa atggcctata ttttgaattgtttttcaagt
32461 tacagaagaa ctttaagatc tttgtaggta atttctaaaa agcataaatatcttaaaata
32521 tatatctgta ctatcaccat taaaacttac cattctttgc tctatattttccaaagctat
32581 attcagagaa aataaaacct attatttcat agcctgcttt aaaaatatctcttaaaatac
32641 gctatttttc atctcctgat ctatccctca agaatatgat tttaaaactgcattacctca
32701 tttcgactta tttgttttat gtcctccttg ttattaacta tttttaattttttctgtgta
32761 aaaacactta tttctttaca tattttctct aaatttggaa gctatgccttcgtcaatgat
32821 accatgttaa cattttaaat ttttaaaaat attttaatat attttattcaaacagtccca
32881 ataattaaat ttatttcact ggcaaatgcg atataaacca attgctgcatctctcctctc
32941 caaaaagcat gtcttgttct agtgatgtat ttggagatag aagacttaaattattttatt
33001 tttttttact ttttaaaaat gagaaatgaa aactcggcta tatgcatggtgtacactgtg
33061 acgttttgat tgaagtacat tgtggaatga ttaaatcaaa ctgattagcacattatcatc
33121 tcacatactt atcatttttt gtgatgagaa tgtttgaaat ctactctattattatttacc
33181 atagtcacca tgagtatatt acatcttcag aaattatccc ttctgtctaattgaaactgt
33241 accctgtaca caacatctcc ccgttgacca ccccaccagt ccccgagcccctggtatcca
33301 ccattctact ctctgcttct atcatttgat ttttttaaat ttctacatttaagcgtgatc
33361 atgcatattt gtctttttgt gcctggctta tattgctaag cataatgccctttagtttta
33421 ttcatctttt tgcaaatggc cggatttcct tcttttttat ggttgaacaaagtacctttt
33481 ttccccccac tgtcccaaat atatgggctc aacccccaaa ttggcaggtctaagaagtct
33541 ttccaaaggg tagtctatta catttaattt ctaaacataa gttgaagaaaagaaaattta
33601 tcctgacagt tccaaagttc aataaaaagt atagtttttg agtttttacttcagtaaggt
33661 attattttag tttcttagct tttcagaaag tctcagtctt ttcaatgggaaactctctta
33721 gggcatttaa aatataattt gctaacaatg aacttttaga tgagtaatcgtggctgctat
33781 cactggccct ggatggcagt gggatgagct tgcaatgcca aggatacagctgagcaaatg
33841 ccactggaag ctaaataaca tgaaagaaac cagggttttg ttgtttacaatggccatgtg
33901 atggtatgag tacaggaaag ggctagaacc tgggcatctg aggagaaaaagcattgacag
33961 catggatgta aatgacgact ggtatttgaa tgcaatgtgg ggccagaggtagacatcatg
34021 gaaaagtatc agactttgca tacaggacac aaactaaagt aatcactagggttagaagag
34081 gagcccactt tctggagata ggttactcag agcaagaaat gcagcaagtcagaaagctgt
34141 cgatttggga agctacttat taatgtacct tacatcctcc ctgacaacaatcgagattga
34201 taaccacatt taattcagtt ctagtcagta agacggaggt tttctagcaccagctgccaa
34261 gattaaaaaa tgtgcatgtc ctagctctgg gaagtgtctg gtatgattgatgcttggtac
34321 ttgttcatct aaatatgaat ttactactgg gaaagaaatt aaacttctagatattcattt
34381 ggtagatcgg tgaggtgact gaagtgtggc aaacctcaca atgattatgaataaacttta
34441 ttaagaaaaa ctgaggcaat taacttattt gttcttcaaa actgaggaaatatttgtcct
34501 cacatatatg atagaatatt gtttgctgct ggtaaccaat ctttgctttcttctactaac
34561 aacttgtttg tcaatatgtc ttatttctca ctctaataag actatgtctaaataacttct
34621 ctcctaaggg ttaaaaatac aaagaatttt cacacataac caagtaataaagaatgtata
34681 ttattgaatg aatgagtaat ttacaaaaga aagtgttgag aagtagaatacataatttca
34741 gatttatgaa atatgaaatt tcagattcag gatctgtcca gtggagttgtgtttttactt
34801 ttatggggat taagtcaaag gcagtatatt aaatataatg gaataatattcccccaaaac
34861 atggtaaatc tatactttcc ctgaatataa attttccttt aggacaccaaatctttaatt
34921 aggttaatta taatttcagg tagattaaag aggactattt ctctttaaacataaggataa
34981 ttatatgaga attaaatctg tgagaaagaa ttggaacctg aaaaagacaatggagaaaac
35041 tagcagacgg tatgttcaac tagaagaaag agaatttaaa agttaaacccaaggtggtga
35101 ataatcacaa aaattgttaa tgaagagcac tttttttttt ttgctgatgttctttaaagt
35161 tttttagccc tggtaataca tatttagaat tattttagaa tttgattatctatgactgta
35221 ccaatattat tgtgttagca gtatgagtct tgctttctat tattgaaatcgttgttaaca
35281 gatcaaatta cccattatag ttttatgctc tgtgcataca gtggcatgacttagattaga
35341 agaggtggat aatgttgttc tcatattgat attataagct tttatcacagatctagggac
35401 ctttgtcttc taattcttgt gtgtttatta ttgcttattc cattcaattggcatgtaatt
35461 gaaatggaat tgaagacaag tacacatgtg tgttccttta tggcccctaacattcactgt
35521 ttagttatat aggtctagat tatgaatggt gcctagaaaa aaaagtatgaataaggaata
35581 attaataatg aatacttatt tccatcacct gttaacatac tctgtccatttattcctcat
35641 tttaccgtct acatttaagt tctcttttct agccaccaag cattattgtctagctaccat
35701 ctactgagtg tttaatatat gtccagaatt gagcagagtg ctttgtatgtaattcatata
35761 accaatctag caaacatcct tgatttttca ttttacctag ttgcctaaaccttccagcaa
35821 tctattagga agtcaaaaag cttctcttcc tctgaaatat attccaaatccatccatttc
35881 acctgttatt cttctaggct aagctgtcat catcctttgc tctggtgattgcaatagaac
35941 ctaattgtcc tatctttttc ttgctttaca cccttaaaat ctaatctacttcttgaaatc
36001 agggtgtgtt tcattgtaaa tgagataata tcatttctac atcttaacctagcagtgact
36061 tctttccatc atatctggac taaaatccaa actctgtatg gatgataagacctatcagaa
36121 ttggagtacg tttttttcat ccccatcaca tgccatgccc gttcttttcaaaaggctacg
36181 gctctttctt gtctaacatg taagcacatt cttttcaaag agcctggaatgttcttccct
36241 agatgggcat gactggctct tttttgtgga ggtcccagct accaattccttaagggaatc
36301 tacccttcct tatctgttct aaagtagcca cccagtttct atcatgaccctcagtttatt
36361 gtcatcaaca cttcattttc ttcatttatt gtttattcct taattgattctacttcttta
36421 gtagaaattc cagaagcttt aaagtgtttt gttcatagct gaatgcccagaacctagact
36481 aatttttgac attcaaaaaa tagcttataa gcatttagta cattttattaaataagaaaa
36541 tagtatctcc tctaatctca gaatattata aatttatatt gttattatcacttaatagat
36601 ttaaaaagtc atgaatgtgg gagataagcc cagggttatc cagttatttcagtggcagag
36661 tcagaatttg agctcatgtg tttcagacct tagaacttta cctatagtctttgatgtcta
36721 catcacatta tgctccctcc catgtaccaa attattctct taacttactatatcaactaa
36781 tatatctata aaataatctc tggcatagga atatagcatt catataataaatcattactg
36841 taatgcgttg acaatgcatt acagtaaata atgcattact taacctgatacattattcag
36901 ctgtttagat gagtcatcaa cctaaaaata tctgactggc tgtacagtaatgtggtaata
36961 cattcatcat agagaaatta acgtatgggt tgaatattca tagtgatatgaatacaaata
37021 tgtgtatcag taggattatg gatgtatgat agtttagtat ttacctagcatgtcaatgga
37081 tgataacaat tatctgcaaa tatttctgag tgttttaatt tgggtttccctagaagtaga
37141 ctttgagaca gggaattgag gcaaggagtc tatctgggag gcaatcccagggcactttgg
37201 caggaaaatg gtaaaatgag acaggatggg agaggaccca ataaatggtatgttatcaag
37261 cgagctatcg ttatgggtat ctggagttta attctacagg ggactctatgaaacagtgta
37321 gaacacacaa ctcagactta tcctgaccaa gatgcaaggg agctgggtatttatacaaaa
37381 agtcttgtta aactttggct tagggctgct ctggggagca taattacttgtctcctgtct
37441 gctgtaagtg ggcagcatgg gttctggcag taagagcaaa aactcagggaataaagtgga
37501 gatgataaca gttgaaagtt ggactggtat ctactgaaat actgagaccatggacagctc
37561 gcaggctatt aacaaggtct tctaaactac tcatatatgc atggtaatctgcatgcattt
37621 ctgaatgtat acatctatac gaattggaac caacagatga aagtaactacatgaaaactg
37681 tgaaatatag aaattactta cctgtaatag gacagataga atatacagacaatgctctta
37741 agttcatggg tttctatttg aatgtatatg ttggtgcaga ccctgtgacaatctgtattt
37801 tcaggaattg taggtatatt tgagaaagtt atatttttat gtaatatataacagttctct
37861 ttaggactta tcagtggata tcctaagaaa cttttaaata ttttcctatgtttattcatc
37921 ccacttcaca ctggtataga tagatagttt tttgataact caaatctacctgtggtaagc
37981 agaataatgg cccccaaaga tgtccacaac ctactccctg gaacctgtggacttgttacc
38041 tacatggcag aaggggtttt gcaggtgtgg ttaaattaag gatcttgagatggaaagatt
38101 atgatcctgg attatctaca tggttccagt gtctttacag gctctttataagtgaaagag
38161 agaggatgtg gagtcagatt cagaatggtg tgatgtgaaa aagactcatctggtcattga
38221 tggctttgaa tgtggaagga agccatgagc caaggagagc atggagcttctagaagctag
38281 aaaagggaag aaagtgtatt cttctccaga gccccttaca ggctttgccagacaccttga
38341 tcgtagccca gtgaaaacca ttttggacat ttcacctgca aagctgtaaaaaaaaatgca
38401 tttctaatgt tttaagcaac taaacttgta gtactttaca ccagcagcaatgagaaacta
38461 atgagctacc taataaacac agaggtaaag tcacctcaag taaaaaaaaaaaaaacaagt
38521 taagacctat gttttaaagg tcatagcagt atttccactg tccgtatgtcactgcagtga
38581 taaatgctgt gttttgacca ttgaaagaat tcgaaattcg agtaagcaaaactaagttgg
38641 aattctgcct aattactctc tatttaacct cagataactt ttaatttctctttgctttat
38701 gttcatcatc tggaatatgg ttacagtaat aatattctga cttccctcatgagttcattg
38761 taagtattaa tttgaataac ctaggcgaaa ggacgttgta gtctgcaacatagtacatgc
38821 aattttattt ggctttgtta gcaaataata gtgctaaaag aaatcagatatccaaaagac
38881 ataaattaaa ccacataatc ctagtcaatt tgtagatttc tgagtatttctgtatcaaac
38941 tggcaagtat atgctatatt tatgatgagt aagtcataac agttaaaagattgactatta
39001 attgagagta aaaattgtcc ttgttattgt cttatgcatt ttaatttgcattttctgtgc
39061 cttaaataga aatattttaa aacaattcat gtatgcagga ataaaagcactttagtggac
39121 tattaaatgg taaacttctc cacatcattc atgagggagg agttataaaactgttctaac
39181 tctcaatttc ctaaaacttt ggtaaaataa tattctatct catattctcccttctgtatg
39241 tctttatgtt tgcaaagatt ctttggggca cagaaataaa caaatcatccctatgaaagg
39301 gtcatcgtag ctgccagtga ccaaaagagc tgcctgctga gcagtttcatactgttactc
39361 cagctgccat ggactcatgc gtgaggaatt cacacagcta atcaattccataaggtgcag
39421 ttgctggctt ctctcttctt aagcctgtac ataaggaatt ggcacttgagtgtttcatcc
39481 tgtggactct acatcattcc ttcacaccct ctgccatttc ctggccctccccaaaataga
39541 cccaaagcaa aacaataata aacaatttgc tgtttgattt ttagtcagcactaccattca
39601 ccagccctta agaatgccac agcagctgcc tgtcactgac tgtttcagcaggatcaggct
39661 agaggtagga gaggcggggc aaaatttctc ctccttgtag gttttagttaattgctgtca
39721 atgacaacta gcagttgtgc acctgtttcc atgcatttag tttctaccctccatcaataa
39781 attctaacaa ttatttattg aacatattct atagttttgg tccttaaaataacatctgat
39841 tataggtact gttgttatca aatgaggaag cagacttcac aaatagcaactgggccacaa
39901 atcttgctac caagtgtcct agccagtggt cttggaagtc taggctctttccctatagcc
39961 cccctgattt tattagccaa gttctaattc taacatggga aagtcctatttcttagttat
40021 gtgtgatgta acttagattt gtgtgtaagt tattatttct tagttttgtgtgatataact
40081 tacattatca tgtacatgtg cacatttaca tcttacatgg gaaattttaatcagaggatg
40141 tcttcatctt tgcgtcacta ctgaattgac taaagactca ctcaaagacatttccgtttt
40201 aatagtgaag agaaggaagt gattctcttt gcatcttatc ccttcatcctacaggcattg
40261 tgctcctact gaacactgaa gagtagtttt gttggcagta accttagaacgtttggagtc
40321 aaaagttgtt gtctctatta cactcagatt gtagaaagtc agcaggccattcggagtgcc
40381 aatatgagct atgtaaaagt catctcaaga ctggaggaag agtgactcttgaggccttta
40441 ttttccatat aaattgtgcc ctctgtttcc tagcaccttt caggatccggggcagcctgt
40501 ctgccatttt ccacttgttt agggctttaa aatcgtaaag aacttcattaactccatgaa
40561 ggccttcaat ttaatattga ggatactgga gtatttatca cagaaaagatacagctcaaa
40621 aattttaacg caatttcatg gaaaattaaa aaaataacta ttacattttggtaagacttg
40681 tatactgaat ttttcagaat gtaagctaaa ttgggtttaa tcttatattttataaaaaca
40741 aagaaatatg aaatttatcc atttattttt tttttcttta tgacatattccaaatataca
40801 gaggaggaca gagacctaaa agcctcaggg acccatggtg gggctctatcaaattctttc
40861 attttgcctt atgtttccag atattgttat gagaaaaaaa cttacaggtaaattgaagac
40921 ccccatataa gccttcagaa atctcattcc ccttcctcca ccaagttaaccaatattctg
40981 aatttagtat ttatattttt atgctttttt tttacgttta cacatatcattgatctatcc
41041 aactttttgt aaattatgtt gtgctgaaca tacattcttc aacatgttattttctgtttt
41101 tgtttatgtt ttattttagg gattaagcct tgttgatgcc tatagctttaatatatatgt
41161 agaaatctgt tgtatgaccc atgggttagc aattctctgg taaaggatattccattttct
41221 tcaaacattt tgctgctgca attagtactg tagtgaacat tttgatgtttccttataaaa
41281 agaatggtgg tctttttagt ttgtaggaat tctttgatca ttctattaatcctttgtcaa
41341 ttatgtggtt gaaatgcctt gaattttcaa atttatttgt atgaaaatactgacagtagt
41401 cccttatgat ttttgccatc cattctataa agagctattc gcgtttcaattctaaaattc
41461 tttgtaagtt ttctctttca ttcttggaag actgtttgtt tactctttagtctcttcaaa
41521 gaattttgtt tggttttttg gctctctcta tttctgtgtt tatatttcactattttatac
41581 tgttgctttg attaaatcct tccttttaga ttgtttaagt acattttcattctttttcta
41641 acttcttgag ttgaattacc ttaaatttat tattctcagt cttatagtttttaataaatg
41701 tatttcattt attaaataaa tgtatccatt tctcttttaa cttcttcccacaagtttgga
41761 aaagtattcc ttttattgta aagttctggt tctctttctt ttttttctttttgtcctatt
41821 gggatttcct gttataaccc atgggctact gaagttttca aacgtatagaaattttttgc
41881 agaaagtttt tgcagtatct attaattaac gatttctatt gtaacatcatggtaaaaaaa
41941 cattggttct gtaagatacc aattctttga aattgtttgt gatcttttggaacccagctg
42001 gtggtcagtt ttcataaata gtttttgtgt atctgaaaaa gatgtcaatccagacaggat
42061 tttatatgta tacctatgag aagaaacttg ttaaatttat gttagatcttttctatttta
42121 ctaaattcct gcttcccctg aagggtttag gtatgcaagt cctttagaaatctaaaggta
42181 gtaatgttag gtttataatt gaaatggctt ctcagtggac tctacgtcttttactgtatt
42241 gtgaaccctt tgatgcattg ttttacattt ttttcttact ggcattagtattactacata
42301 tataaatttt tttcaagtta gtatctatat agtatatttt cttcagtctctattttaaac
42361 tttcaaaaca aatatagttt tgttttaggt tattcttgta atcatcatgtagttttataa
42421 aaatctaatt tgattatcac taatatgtga gtttgataaa tccacatagtcataattact
42481 gatatgtcac aacacagtaa gggctgtggt cttcatttat ctgaacaactgctttacatt
42541 tagtttcaga gatcggagta ataatgaacc tttctgcatg tacccagtgttatgactcct
42601 gtaaggatta atttaaaaat gttcaatatt tattttcctt ttggattttgctgaaaattt
42661 aattttagaa ataaaaaaaa tctctagttc tttcaaattt tccatgaattgaagattgtt
42721 taccgatcta tttttttaat actgcatttt ggcataattt tttaataaatgtttacactg
42781 taattttcag taattcagtg taaagctaac aggttttttt caaagatgaagagacacaat
42841 atgttataga atatagtaca tggtgggaca gttaagtagg ggttctggagtttatttttg
42901 cttctgctac ttaactatgt tattacaaag aaaaaaatca tgtaagagactccgccaaat
42961 tctcttctgt ataacaagag ggagtgacat actatctcaa tttcagttttcatatttaat
43021 gactcacaat tggatttttg gtatatattt gaccactttc taagattttattttttatgt
43081 tcttgaaaat tttatattct ataaatattt ttgtatacat atgtacctcacattcaaggt
43141 aagaaattct taagtaattg aactttgtgg ctataattaa atatatacactaatagatga
43201 cagaataaag aaaatatttt tattctgaga gcctaatttt aggtaatgaaaatcatttta
43261 tgggtaaata aagtacacat tttatagtgt gctaaaaaat acacaaaatttgacatttaa
43321 aacaataaaa aatattaaat aacttggaat gaaaggagca tatcgaagtatttgtgaata
43381 aataatctca aattgatttt ttccaacact ataacatctc ttttctgtttaaaagaagtt
43441 taatagttgg ttcaatcttt tctttgagtt tgttttttat attttccaagcttttaattg
43501 tcagtggagg gagaggactt gagtgttttt aaggtttcca tcaacatccattctcctgta
43561 ttcattgtta ggccaaaagg actcaacatc tttgagtctt ccctatttgagaccaagtct
43621 atactcagct tctaatttca gctctagctt ccattcactc tcagtctttgttagcattat
43681 ctaagtttag gttgagatta ttgcattatt gacttgcatt ataaacttcttctttcaaga
43741 ataatatgac cttttaatct tgttatatat gtttacccat catttacataaatttttatt
43801 ttatattcca tatggtttta ttccaacagt cttttgtagt taaatattttatactcattc
43861 atcataaatc ttcaagtaat ttttagaaga attttgtaaa agtatatgacttttttaaat
43921 tttgtgggta gactatatca ataaaatatt taaatatatt cagaaacttcttttaaagtt
43981 catatcactt tactttggta aagagtttta gcaaaagctt ataattaaaatatgcgacag
44041 tgctcacaga gcatttctga ttactatcag aaataggggt ttattctggaaagttgtttt
44101 cctgaaagtc ttaattgtaa aaagtgcagt ttaataccta ttatattcttatgtgtatat
44161 taatgccaaa ttaagcaatc ttcctccctt tctttcttcc ttctttcctttcctctttcc
44221 ttcttttctt cgtttctata tttatgctgt atacgtacta cttgaaatatccagacacta
44281 ctatttgttt aattcacaag ccatatctgg tgatatggat attattgttcttgtttcata
44341 gttgaagaaa ctgaaacttt aatgaggttg gataagagcc acaagtatagcagattttat
44401 agtgtataac cctgcaaagc tcaaatttgg attgatatct ctgtttattctagaaccctc
44461 ctctgtgtca ttctatgtca gtttgctttg ttgtttatta tggtaaagtaatcattcttc
44521 acttcaacag ttatctgtga gttgattcta aaacatagaa aaattttgttttaaaataaa
44581 ttgtatgtat gtcgtcacct aataatgggc ctatgtgggg tccacacaaaaccagtttgc
44641 tgcagtcttg gcatagtgta aaattcccaa agtttttata tacatattgaatgcctcaag
44701 gtatatttta aaagcccttg ctaatcccaa aggaattgtt ctaaaaatttgtttaaatga
44761 aatttttata tattttaata tttaaatttt aaataatatt tttaaaaatcttaggctgaa
44821 ctttcagttt gtaattagca aagtaattat tatttgcccc aagccagcttcctcctattt
44881 cctgaccctc atttgtcttc cctccttata agatgcttaa tgaaagagaacttgattttt
44941 gttcatttgt ttttgagaca gggtctggct ctgttgccca ggatagagtgcagtggcaca
45001 attgtagctc actgcagcct tgaacctggg ctcaagggat cctcctgcctcagtgtcctg
45061 agtagctggg actacaagct catggctaat gagcctggct aatttttaaattttttgtag
45121 agatgggggt ctcgctgtat tgcccaggat ggtcttgaac tcctaggctcaagcagtcct
45181 ccagcttggc ctcccaaagt actgggattg caggtgtgag gaccacgcccagccttgaaa
45241 cttgattgtt atttacatgg tgcacttaag aagcctaatc ttaccttctgacccagggtt
45301 tgcagtcaca gtccttagag tttttgaata aagactgtgc tatttcttttttttaaaagg
45361 gatttgtttt tatctaattt atttctgcct ttatgtttac tcattattaattattcaaaa
45421 taagattggg atcatcattt atgtatgaat aactcaaatt agtttattgtaatacatagt
45481 cctggtgaag aagaacatat tcagttcatg ccttcaattt gcatttatcttgattagtgt
45541 ttaagtgcat ctcatttccc tatgcttctg ttttcatagc ttatataactacactgttag
45601 attttatgca tgatgtaaca ggatacaatc ccatgatata tttccatgatgtcaaagctt
45661 tgaattatgt aaataggaaa catgaagcaa aagcatacta cttattcattatgcattgct
45721 atgcggcaga cgcacagtca agtgatgcta tttaatctcc ctatctgcatattcttaaag
45781 tgcatatctc tgtgatatcg aagcactcaa gcaatgagta aatttctgcatctggttaat
45841 aaattcagca aacaggagtt catcaacatc tggcatctgc cttattttactggctttata
45901 tgaataactg atggatggcg acctttgata aatttagtgg ttgcttggaattttagtagg
45961 ggtttgatat tgtttgtgtg ctattgtgaa tttaatatgg caatcaactttctcttggtt
46021 gctttactca tactagaaac cacagcatca accaatcaaa aggctgtttagcatttggtg
46081 ttatcacata taccctaatt tgcacaactt tccaaaatgt aagtaccaagagagaagaca
46141 catcaataaa atataggaat tataaggaag aggaagaggt ttttaaaagtatattattat
46201 tcagcaaata atggaaactg gtgctcacaa actactaaat taagagggcttttttccttt
46261 aaaaattaat gcaatgatag tgcagaacac caaataaaaa ctgcatagccaaggctctgg
46321 aaggttgctg gtggctcctg gacatcagtg ggatttcaca tctttctctctgacatatca
46381 tttgttcatt tccagagaat gcccagctct gtgttttctt aaaaataagtttagaattct
46441 cataaaggtg gacattattg gcctagcatg agttaatttt ctctacccctggacctggac
46501 caatcatata tataagcaga gagcagaaag gtagcacaga ctgaggcaaggtgaggataa
46561 ggtatttttt gtgtgtcaca gagacacctt gcttgtctca tttttgaaaatgatgaaaac
46621 aaatggtgac taataaatag aaaatgctct gtggtattat cttctagtactaatgttttc
46681 ttcactgtcc ctggcctggt atctttcttg gcatacctca caaattacttgacttctgtt
46741 ttatgttgac ttcactcctt tacattacat tattgggaag ccctaggtcttagaaaacta
46801 tttcttaaac tgaattaaaa ttttgccctt gtacactggt actggctctgtcctctcagt
46861 aatagaaaag aagtcttcca tatgtccaca gccattattt gcaaaaagatatctctttct
46921 tcaggcttat gtttcccatg ctacatctct cttgttctct gaaccacactttatacagcc
46981 tgactttcca tattctcact gttgctgtca tccccatctg atcattcccctctgtcttaa
47041 aatgtgacaa ttacaactgg acataatact ccatctgtga tcttctcaggacagacccaa
47101 gcaggtccca gtatagtgtt agcaggacat cacatttttg gcttcagatgaacctgtaaa
47161 tacctaaagt acctggactt ttcccatgaa ttgttggtag gccaggatgtgtgccccatt
47221 agttggggac actttctagt gacagttcct ggaactctat ctggctatttctctagtcag
47281 gcagtgaagg cagataaatc ctcggttcct ggcaggttca ggtggaacacgcagcacagt
47341 gtgcgctgtt gaatgagtgt tcccgagatc taatcacatg gaatgcctgattgtcaaatg
47401 atgaacaaat aattcaggag atggacctgg gagttgaaaa tttttttaacaaaaaagaaa
47461 ttacatatat gcatttttaa caaaagtttt ataatcattg atatagtgatggtagcacca
47521 gtagatattc aggcaagtaa ttatcaactg gatgacttat aaaggaattgataaagcctc
47581 ccaagggatt caagaaaagg gtaaagcttg gaagtcccta aggataagtggctgagatgt
47641 ttgattcagg acttcctgtc cttgaaacct tggtcagtta ctagcacgtaggacagtctc
47701 tattgtggac cagtaaaaag ctggttgtct ggagaattca gacagaaaaggtaaggctgg
47761 gacccagtta tcaaggctgc actacaacta gggcttgtaa aagttaggggattttggaat
47821 tagcgtagaa ataatgtaat atggtgtaag taacacaggc tttgtaattagtgcaaaaat
47881 cataagcata tgggcttgag tcagtcttct ctttcctact tactggctgcataccttttg
47941 tcagctattt aacctctctc taagcctcag cttcttcatt tataaaacaaattaatatta
48001 tctacactga agtattatag gagagatgat aatgtatttt ttaaaaactagcacagaccc
48061 tggtcaacaa taataaacat actaataatt gttactatta taataaacgtgttgatatct
48121 ttttcttcat caatgacttt ataaaaatat tgggatggag atgccaaaatctcctctgct
48181 aaatgccatc tttcatccta aggctataca ggaacaggcc ttgcctactgaactttgtag
48241 ctataggcct actacattgc ctcccacttg aaccctcggt tataaacggaatggagagtt
48301 acttttccat tcagaaaaga accttgatat ttcagaagga aaagttagccctggacactt
48361 gagcatttct aagaaaatag gttttttttt tctttttaaa ttgtgtacctgctgccctga
48421 attctctaga tgttctgagc actctgtata ttcttactca tagcttagtaataaattatg
48481 tttataaatt ggagactggt attgtataat ttagttcatt gaaataatttgatctggtga
48541 cttcatagcc agacagagtc aatggattca tataaatgag aatccagggttaatcaccat
48601 caaacatttt caacataaag tgacattttt ttccttagaa tgggatttttactacattca
48661 aattttacta atgctgtaaa catgaaaatt ttgagtcagg taatgaatttgagaatggat
48721 agctaatctt taaaaatcta gtaacaaatg tttctgggaa ttgtggctattgttcccttt
48781 tggaatgatg accaacattt ttggaaatga aaatattgat aaatttgtgtggacttaaat
48841 atggagtcca cacaagattg gggtcatagg acagaaacaa tatttgtttcacatttacat
48901 tgctgaggta ttatgaagag gttagaaagg tgatttttat ttagcttgcagaataaatat
48961 tttaaaatca cagaataaca tatactatta aatgcctaca tacatttatatccatatgaa
49021 taaaacagta gaagctgaaa tataaaataa catgccactg ctgctggagagatttaagcc
49081 aattatctgc tatcctggag catcagacat atatatctat atctatctataatattatat
49141 atttcataat ttatatattt atatatcggt ataatatatt gttttatacagattatatta
49201 ttatatgctg tttttcacca atgttgttta catatattat acattatttatatccggtga
49261 ctacataatt gtgcatggta catcccgtct ctagtcagtt gtcatgacaagagttttaat
49321 catttatgct tactttatga ttctattgta caatttttat tggacattatttcagttttt
49381 attaattaac agggcatatc aaatacctcc atacacactt tattacagatttttttgtcc
49441 caaatatttt tagcattttt ttaaatatga aaatagatag tttggaaacaagcttctatc
49501 atctactatt tcttcagtta tttgaatgca gatggcctat cacaggacacaagaagttga
49561 gaatgtgcta ggagaattgc cagcactgct caatacaggt gtttgcccaggtctaccttt
49621 tgactctctc acttgatctg ttcttgtgct tctcactttc ctgggcagccagtcccttac
49681 tgagtatttc tggccttcag tatctgcttc ttccggttcc tttgatgcagcacccacttg
49741 ggctcgcttc tgtagttcgc taaactcagt tgcttatcat tgtaatatttccgtaatatc
49801 agaatgacta ctgtctcaac ttaggagaca tccacttgtc ttctccagcacctgactgag
49861 ttcttgccat ataaattttt gttgaataaa ttcaatgttt ggcttttcacatcatcataa
49921 acaagactta caccaacaat catgggggaa tttgaataaa attaagattaggtctgactt
49981 ttgcaatttt acaacttaca agttagtgtt aagaaaatgt ataaagatggtgatatgcca
50041 ttttgaaaca tattaagcat tttcatcttt agaacagcct tcaagagagttattatgaaa
50101 cacatttaag cttaagaaag ctgagaatca gaatgataat taataattatttgagggtgg
50161 atgaaaaagt aaagaacatt tacacagttt tagtgagaat gtaaattagttcaatcctaa
50221 ggaaaacaat atgaaaattt ctcaaagaac taaaaataga actacagtttgacccagcaa
50281 ccccattact ggtatgcggg tggtactata taagaggaaa agaaacatcctgtcaaacag
50341 acatctgcac tcatgtttat cgcagcacta tttttaatag caaagtcatggaatcagcct
50401 aagttcctat cagcggggga ctggatacag aaaatgtggt acatacacaccatggaatac
50461 tatgcgtccg taaaaggatg aaatgatgtg ctttgcagca acatggactctgctggaggc
50521 cgttttccta agtgaattaa cacagaaaca gaaaatcaaa tacttcatgttctcacttat
50581 acgggagcta aacagtggtc atgtaagcac ataaagatgg aaacagtagacactggggac
50641 tccaaaatgg ggggaaagag ggaggagaac aagggttgta gaagccaaattgaagcctga
50701 aacaatacac ctttgtaacc cacctgcaca tgtggcccct gaatctaaaataaatcaaac
50761 aaaaaattaa caagcaaaca aaaaacagag gaactagggt ttgaattaatatttctgatc
50821 tgcatatcgc tattttcctc ttaaattatg tgcttaaata catgaagaaggaggaggaga
50881 aaaaaacaac ttaattagga gacttacttt aataatgtat catttataacttttcttcca
50941 aaatctggtt acatgtcaag aaactgtata atgtgaatct ctctagttcacctttccttt
51001 cctttatgta gatcttggtt gcaattcaga ttttcttttt tctaatgaacagtacaatca
51061 gtaacagttg caccaaacat ttcaatttgc aatatacatg taatggtttttcaagtgaag
51121 gttacatttt atcttttttt attatccata gaataatgtg ttttaggatgaaagagacac
51181 tgtgtgtgtg tactccgttt aaaattaaga tctgacggtc tgagacatcacatacaaagc
51241 ataattcagt agctatctga cagtttccca attgctatga cactaaaaataaaccaaacc
51301 agataaatca accccctaag tggactctct ggcctgaaat gttcgggttttaatgtgcct
51361 gtggaatgtt ccaatataat tttcatcaat gttgattgtc cagctcacacagccctgggc
51421 actagagtga ttgacataaa ccccgtcatt attccaacaa ttaaatcagcaggaattagc
51481 acaaacattt ttttcctgtt ccgtacacta aaaatgtttc catgctgcaatgttaggatt
51541 taaatgtaac aaacataatc ttccctgtgt tgtataactt tccgatctactaagaaagcc
51601 taccaaaatg gagcatttgg tttaaaaata aatacctgga ctcttccatgtggcaacaaa
51661 caatacataa gagatattgg acaatgaaca attaattaca ttgataaaaataattgatga
51721 attaagaatg taaatctaaa gatactttat attcctcttt ttggtttaactttcaaatcc
51781 agaaagctct taacctggtt aactaatcga tgataacgtt atacaacaaacttttgttga
51841 gtacttgcta ttcattcctt gaacgttatt tattgtaata aacgtgttaattgaggttct
51901 acatatataa aactgtttaa ggtgcaatga aacaaaaatc acctgaacttcggacaaatg
51961 tgatttttgt ctttgcttag gacgtttttg gaatatttac ttttgaaaatgtctccatga
52021 cctgtggcag tgttttcttc tgaatagtat aaatgacgat ggcaaatctaaaataagtta
52081 tttggagcca catctagaaa ataatgtgag tattccagtt attagggaaggctagatttg
52141 atcaaatata tatatagtta tatgtattct ctctctatat atagaatatatagttacata
52201 tgttctatat atagttatat atactctcta tatatagaat atatagttatatatactctc
52261 tatatataga atatatagtt atatatactc tatatactct atatagaatatatatataac
52321 tatatataga atatatataa ctatatataa atatatagtt atatataactatatatagaa
52381 tatatataac tatatataaa tatatagtta tatatattta tttataaatatagttatata
52441 tactctatat agatatatac tctatataga gaatatatag ttatatatattctatatata
52501 tattctatat atagttatat attctatata tagatatata ttctatatatagaatatata
52561 gttatatata gttatatata ttctatatat ataacttcta tatatagttatatattctat
52621 atatagaata tatatataga atatatgtat agaatatata gaatatataatatatagtta
52681 tatatattct atatatcgaa tagttatata tattcgatat atcgaatatatagttatata
52741 tattcgatat atcgaatata tagttatata tattcgatat atcgaatatatagttatata
52801 tattctatag ccataatgcc tattagcctg gcatttagac ttgcaagtgtcaacttatta
52861 cttaccttgt tttattttat ttctttaatg atctcaaaac cttcctctctcgatttcaat
52921 ctgtggtttg ttcccaccat ttgccgaggt ctagcatctt attctttgattttctttttt
52981 cttttcttca acttttaagt tcaggggttc atgtgcagga tgtgtaggtttgttacgtag
53041 gtaaatgtgt gccatggtgg tttgctgcac agatcatcct atcacataggtattaaaccc
53101 agcatccatt aactattctt ccgatgcgtt ccctaccctc atacgctccccccacaacag
53161 gccccagtgt gtgttgttcc ctcccatgtg tgcatgtgtt ctcatcattcagctcccact
53221 tataagtgag aacatgcagt gtttgctttt ctgctcctgc attagtttgctcaggatgat
53281 ggcttccagc tccatccatg tccctacaaa ggacatgatc tcgttcctttttatggctac
53341 atagttttcc atagtgtata tgtaccacat tctctttatc cagtctatcattgatgggca
53401 atgattttgt aatataatga tttatattcc tttgggtata tacccagtaatgggattgca
53461 gggtcaagtg gtatttctgc ctctaggtat ttggggaatc accacactgtctttcagaat
53521 ggttaaacta attaatactc ccacaaacag tgtaaagggt tcctttttctccacaacacc
53581 accagcatgt gttgtttttt gacttcttaa taatagccat tctgattggaataagatggt
53641 atctcattgt ggttttgatt ttgcatttct ctaatgatca gtgatattgagcttttattt
53701 catatgtttg tcagctgcat gtatgtcttc ttttgagagg cagaaataccattcgaccct
53761 gcaatcccat tactgggtat atacccaaag gaatataaat cattatattataaaatcatt
53821 gcccatcaat gatagactgg ataaagagtc tctgttcatg ttctttgcccactttttaat
53881 gggatttttt tttcttgtaa atttaagttc cttgtagact ctggatattagacttttgtc
53941 agatggatag attgcagaag ttttctccca ttctgtaggt tgtctgttaactccgatgat
54001 agtttctttt gctgtgaaga agctctttag tttaattaga tcccattcgtcaatctttgc
54061 ttttgttgca atcgcttttg gcgtcttcgt catgaaatct ttgcctatgcctgtgtcctc
54121 aatggtattg cctagattat cttctaggat ttttgtagtt ttgagttttacatttaaatc
54181 tttaatccat cttgagttaa tttttgcata tgatgtaagg aaagggtcaagtttcaattt
54241 tctgcatgtg gctagccagt tctcccagca ccatttatta aatagggagtcctttctcta
54301 ttgtttattt ttgtcaggtt tgtcaaaagt cagatggttg taggtgtgtggctttattcc
54361 tgggttctct gttctgttcc attggtctat gtgtctcttc ttgtaccagtatcctgctgt
54421 tttggttact gttgacttgt agtatagttt gaaatcaggt agtgtgatgcctccagcttt
54481 gtgctttttg cttaggattg tcttggctat ctgggctctt ttttgattccatatgaattt
54541 tttaaaagtt tttctaatgc tgtgaagaat accaatggta gtttaatggaaatagcattg
54601 aatctatcaa ttactttggg cagtatggcc attttcatga tattgattcttcctatccat
54661 gagcatgaaa tgcttttcca tttgcttgtg tcctctctga attttttatcagtggtttgt
54721 acttctcctt gaagaggtct ttcacttccc ttgttagctg tattagcatcttattctttc
54781 aagaggacag tttgttcagt ttgtttaaat tattatcacc atcacaaccattaaaccttt
54841 attcagcaac tgaagaatgt accacaatat ctctcatttg caagacatattctgttcatc
54901 ttctgctttc tgcttctgta gcttataaag atatataaat atattttaaacccaatttgt
54961 aattatatat gatgggaatt gaaaacgtgg gtgattttca aataatcactaaggaataaa
55021 atatgctaaa aataaattgt gaagaattga tatgattttc taaggatggctttactggag
55081 aaaagcagtt atcctacaat agttaatata taactatttt tatgattattctgttcagaa
55141 tctgaattta tattattatt tggggccttt tttaatcaag tgaagaaaggtatattttct
55201 tttcaaactt tttattttga acattcataa attacatgaa cactaaaagacataaattat
55261 ctttcaggaa acattgaata aattctggat tcgtctatat tttattgatttgtaaaacat
55321 ctcaaattta acatagaaat gttaaaaaga gattatatta taacgtttgttggaaaatat
55381 gctatattta taatatttat tctgtattta tatattataa atatattctatatttatata
55441 ttataaacat attctatata tattataaac atattctata tttattaacatttaacatta
55501 atgttaataa atatagaata tttttcaaca aactttataa tataattccctccttcaatg
55561 aactaatttt tatggtggtt tacatttctt tttcaatgtt ggtttacatttgacgttagg
55621 atgtttatta gttaatacaa taaagtgggt ggtcttttca ttaatattatcagtcaggtt
55681 tgtaaatagt gtatgttttg tataaccact taaaatttat atactgatatatattttgtt
55741 taagaatact taaaataaaa acattagtta tcatttgttg aactggaaggatcattactt
55801 aaaaatccat ccttaaaatt aaaatgactt atgcttcact gtgtagtgcattgataaata
55861 tttagtctat agttttttct attgctatgt gtttagccaa gaattgtttttaatttggtg
55921 aacagtacct tattaggaat atgaaaattt ttgaagcagt catgaaatatttaacaatta
55981 attatttaac aaacaattat gcaaaattaa ttttactaaa gaaatatttttaaatcactg
56041 caagaaatat tttcattcaa atgagtactt acaaccaaga aagagtcttttattttttaa
56101 atgtgtataa atttaaactt caaaatactt aaatcactta atgcctcagagaaaatatct
56161 taatacttat gaagtgttac gtgtactaag cattatgtta aattctataaagacatcttt
56221 ttaaatcatc acaagaaatt acaaggcagg tgcatctatt atattttttatagtagaact
56281 aattgaggca cagtgagagg aaatgatgta ctcaagttcc acaggtgataagtggtacag
56341 ctgagtaaaa ttccaagtct aaaagctagt ctcttaacta ttatatatcggcctatatgc
56401 ataggccgac aagtagttat ttaaagttat ataaatcaag agaaaacactacaaaattta
56461 cctataggat atttatacaa aatatgggca ttttattagg aaagctttctagaaatatgg
56521 gggaacttta agaaacagtg aaattcaaag ctatcattgt ccaaaagcatgtggtcttct
56581 gtttttgcac tagtgactta ggtgcaaatt acttccaaga tttttctcctaattgagaag
56641 tactttttag gtctagattc catggaggag gtgggtcttc gaggtggggcttcaaggtgg
56701 agatagtgtc ttttttctag catgtaatga ggtaaatttg cttttgaatgaacaggtgca
56761 cctatttcaa ttaaggcaaa ttagtttcca aaggctttgc tatttaagatattatagaag
56821 gctatttaaa tgtgccaatt tacataaaat acattttgaa agattacaggaaacaatttt
56881 atataattca ctgaaacaat ttcacagtcc tctcaaatga tgattttgaaaatgacctaa
56941 atggcaggca cctctttgaa gcagctggca tgatgttatg tggtcccatggccccttaca
57001 ttttcaggtc aatggtaaat tctccagagt ccaacttcaa ccctgcagtattctgttcaa
57061 aattgcccct gttcagaagc ctgcatatgt aacctcttac attttgtgtttcacaatttc
57121 cattgaactc ttcctacaca ccagaatggg caaaaatagg aatttaatttctgggaagat
57181 ttcctctaag agcctctgtc caaaacatcc agtgctgaaa caagaaaaggtggtcctggc
57241 atatatccac tagtaatttt tttgtcttct tcttttcttt cctgttttatgtgtgaatag
57301 tgaaacttat cggttcaaag accgatgagt cagaatgctg tcattttacatccaaacagt
57361 ggaaatttaa attgttaaaa taaaaataca caatcactaa cattaccctgatgaaataat
57421 gataagcaaa gtagtcttaa attacaggct ataagtgctg gataaagaacaatattttaa
57481 aaatatctaa agtcatataa tgaacagaag acagatttcc atttatacctgaaagactgg
57541 ttttcagaaa ttataataga acatggggat ttaaaaattg tatttggatcatttatttta
57601 cagttagaaa gtgatgtagg aaggagttcc cagaggagat gaaacagattgaaaacagca
57661 aaattccatg acagaggtgg cttgaaatag accctttttt caaagcaataactggcctct
57721 tcatcatcta tagatagcat ttttggcaaa atcagaaaca tttgctttgccagtcattga
57781 aggtaaaaag aaaaaaaaaa tggctgaatg cttttaaatt acatttatttaatttctgct
57841 ttcatacaaa ggcataaaat tatcagttta aattttaaaa aatattattataaaattaca
57901 tgcttagaag tctgttgatt gttttcccac agccatttta taactgaaaccctcaatttt
57961 ggatatgaat gtataataaa cgcacatgtt cattctaaac attttcttttcaaatacttt
58021 tacattcctt taggtttcct aaagaaatgt aaattccttc tgccacttagtttttgctat
58081 ttttagcagt ttcttaaagt ctgcaaattc ctttcactca gtttttgcacttagttcata
58141 atgacttcac atttgacatt gattgtccac aaaaggggtt atttttagtttcaaaaggtg
58201 aacgttattt gttttagaaa ttctcgcgta tatttcttag tctaaagataggttttctaa
58261 cataaaaatg tgatagtgta gtctgtttgc tgagcacttg tagtggaacaaactcagtgc
58321 taaattcttg gtttttaata actaatttat ttattacagt aactgctaaatatgcttcaa
58381 attataaact atttgccaaa attacagata ataatataac caaacaccatgtggatttca
58441 cctaaactag aagtaacttg gtgactttct tatttaatct tttatttattgtacttggcc
58501 atacttattg tatgtttatg tataaaaaca taaagcaata gaagtttttacagttattat
58561 actcactgtc ttataaatgg agaaactgag acccagagaa ttttagtaacttattcaaag
58621 ttacctagct ggtgactaga agcaaaacac aaataagacc acagattactagttttgtca
58681 agatcttcaa cataatttaa tattgctgtc aactcagagg tctcagaagataaggtctta
58741 ccatctgaaa acaacaaaaa agaaatttca taaaatcctg tttgtaccaagcaatttatt
58801 tctagaatga aagcaaaatt atttttttaa agttctttag attgctgagaaatcaagagc
58861 attagggttg tgtctcccct ttaaatttac cttttagttt ctttgggtttaagtttttag
58921 atgaaatttt aaattctatt tagctctcag tttatgtgta tttaaaatttagatttagga
58981 tctattcttt ttaataaggg tgaaattaca tatggagaaa tttactgtttatagcgagtt
59041 ttgacaacta gagttgtata accaccatcc ccacagtcaa gatacatcacttctcccctt
59101 cccaaacata ttccctggtg acactttgtg gtcatactca ttctccgcctctagcctttt
59161 acaatgactt ctgttactcc ccctgtagat ttgcctatta aagaatgttatataaaggaa
59221 tcacacatca tgtagcattt tgaatctggc ttgctttact tgttttaatgcatttgagat
59281 ttgttcctat tgtggcagat atcagtagta gtcttctttt cattgttggatattccatta
59341 catgaatgta caatcacatt ttatccattt gcccagctaa agaacatttgggtgttttca
59401 gttttcatta ttatgagtaa accctccata aacatattgc atacaaatttttatgtgaac
59461 ataagttttt gtttcaccta aacagatact atacaggact gaaattttagtaagtatatg
59521 tttaactttg tgagaaactg cccaactgtt tttgcaaagt ggctgtacagatttacattt
59581 tcaacagcaa catgtgagag ttccagttgc tgcacgtcct tgtgagcacttagggttgta
59641 tttttaattt tatccactct aatgggtgtg gagtggtgtc ttattaaggttttaataagc
59701 atttctctaa tttaatgcat tatattactt ctttttgttg gtttgtaaactgcttatctt
59761 ctttggtgag tttgatcaaa tcatttgtcc atgtttgtgt ttttgattatatttcagata
59821 caagtcttta ccagttatgt gctttgtaaa tgttttctca ctgtttatcatttgtgtgtt
59881 ttatggaaag cagaatattt cgattttctg gaaatataat ttgtcactttaaaaattatg
59941 taaattgcta ttggtattaa gtgtaagaaa actttgcttc atctatgatcacaaatattt
60001 tcttctgaaa aaaaagctct ctgaagagtt tttttttttc aatgaatgtgttttctttct
60061 tctctccata tgttatcttc tgaatagcta agcaatgttt acattatttattcaggcctt
60121 tccatccact ttcacggatt ccactgaagg agaaattggg tttgaaatcctcttttctca
60181 aaaactaatg agtcatgcat cttctcattg atattatctg gctcccctgaaaacctctag
60241 tttggtccat ttttagtgat atctttctac tcaggttcct caaaccaatctgtacctaag
60301 agacccccag attaaaattc aagttcattc ttttaacaaa ttaggtgctaattgctacaa
60361 atgcaagaaa acttcaggtg ctaatttgtt aaaagaatga acttgaactttagtctgggg
60421 gtctcttaga tatagattga aaaggattga aaagaattat agtttctttcacttttgcca
60481 tcatacaata tgtattattt atatttcttc ttcgttaata ttcagttcaccttctttgtc
60541 catctttcta ttgaagcacc agtattcatg cagtgtttta agaatattagtccattttta
60601 tccattatgt atattgcaaa taatttcgta ctttattgtc ttttaatttgtttgcagtgt
60661 tttctgccat acaaaaattt tcattttatt ttatattcac tttaaaaaggcctttttcag
60721 cctaagagta taaatataat agcttttcta cttttttcat tttttaatattgcattttct
60781 ctattgtgaa tgttatgctt atgtttttct ccagctgatc tattgaggaacagtgttttt
60841 ttaataaata taaatattgt tatagttatt tctcatttcg aagttttacggtactaattt
60901 gtctgtctta aaacttcaaa taatacttaa ttgaaagtct ctgtctaccatcatcccttt
60961 cttaacagtt cggtgaatat cttttattat attgtgtaag gatgttgtattgcagctcct
61021 cttgctaggc tgaacatgca gacctgttct ggaaatagat gtgatcagtttaggtcacaa
61081 cctgtcttga atcacagctg acttgtagtg gagagttcca ggaaccttccaatcacacac
61141 aggtccctat tgctcctttt cttctagggc tattcaacaa gcagagacaaacaaaaactg
61201 atctgtcaca ttttactgca ggtaacagtg accacaaata cacctgtacactgttttttt
61261 tccaacatta ttgaggtgtg actgacaaat aaaaatggta tatatttaaggtatgtgatg
61321 cgatgttttg ctgtacatgt acattgtgaa atgattatca taatcatgttaacatatcca
61381 tcacctcaca tattgttatt tttataatca cttttataaa ttttcccttcagtagtaacc
61441 ttttgagatt ctgaaacact tttgagtttt gaatgttgtg tcataagtgagtttttttgg
61501 caaatatttt ataaacatct aattgggaaa ctgtgagagg atgttttgtaactttcattt
61561 aaactaagat ctcctctcca cctccaccct tcccatattc agtagattttctatggctgt
61621 atggtgtatc aggaatcatc ccatatactt cagaaagtaa tggaataatataaatatttt
61681 tctaacatag acctacagag attaagtgat atactcaaat cataccataaatggtagtga
61741 aagggtaaac tcaacattca cagccaactt cattatctaa tagggaacaacacatttcat
61801 attaataatt gacttttatt tttaggaggc tctgttataa tgaaattaaaaaatgagatt
61861 agattatgtt tctcaatata tggtacaaaa atcacttaca tagaataacttcgattatta
61921 aaaatagaag tgaaaaatac ttttcagatt aaataagatt tcaattttaaggcaaatatg
61981 ttcattttgt gctcaaaaat tagacaggaa aactataatc tgttaaaatgtaggttcttg
62041 atccacccaa gaaaccatgg agaggtgggg gacagttacc tgcatttctgacagttagtt
62101 cattgactct tattcgacta aactttgaga accagtgtcc aaagtatttacttacatatt
62161 tatatttaaa agctgggata atcatgacaa tataaaataa acaattgatgttgtatttta
62221 cttggcagat agataaagct atacaagttt cctttttcct aattctaaagcataattaga
62281 aaaaaattgt atttatttct tagatatggt aactactaaa atataatttggaatgttcta
62341 cttaaatgag tatacttatg tatgcagtta gccgtcaata agatttagtgttctctgaac
62401 tatttcattt ctatgaaggt ggtattaatc ttgatgataa aattttcttttaaatattga
62461 gagattctgc caaaatataa atcttactgt gacaatgttg ttgaaattcctttcttcata
62521 tgattatttg ttctaaaata gctcccatga aagtaaaatt cctactctcaagcatcctgc
62581 ttaagcatat tgtattgttg ctggtaacta aaaataaagc aaagcattagggtggatttc
62641 agtgtaattt tatctgttta gtagagtgat acaaatgaat aaattttcaaacatacaaat
62701 tgaccaatta tttgaaagag ctatgaataa aataaataag ctaccttaaaattattttaa
62761 aattatatca caaaattttt ttcctaacaa caaaatatgt atttttaattgttttggttc
62821 atacaaatta aaatacaaat ataattttac caaggaaagt gaagtaatttaggagtaatt
62881 aataatattt gtgttaggga acggagcata gatactatta aacctaaccgttttatagtg
62941 catttgtttc taaatccctt aagctggtaa gtcattgatc ttgcatttttctttgacagg
63001 cttatgcaag caaagatctg gaggagcagt tacggtctgt gtccagtgtagatgaactca
63061 tgactgtact ctacccagaa tattggaaaa tgtacaagtg tcagctaaggaaaggaggct
63121 ggcaacataa cagagaacag gccaacctca actcaaggac agaagagactataaaatttg
63181 ctgcagcaca ttataataca gagatcttga aaagtaagta tgggaaataaaatgtatagt
63241 aagccttata tatcaaacca gtagaagttg ccagcctggt tctttaatttcagtgtttgt
63301 atcaccgaat acacctttag ggcggaaagc aaatagaaaa taaagaattacttcaaaata
63361 caacatttta tgatttcact ttgagtatta agatgacttc ataaaatacaggatagatag
63421 gtccatgcat aaacaacaca catttatttt ttcaggtgat agccattggaaaatttttaa
63481 aacagatggc tatattttac atactatatc tgtttaataa cttaaacattctttatctta
63541 tcaaataatt ataccttaat ttcctatctg atttggattg agaaatgcttcatttgaaat
63601 caccttttca gatgtcactt gttgctttgc tgcttcacag ataactggctcagagcggga
63661 cttaagctga tgaggtatct agcataaagc ttcacaaaaa atgatcatgttgcataaaat
63721 gtcatagcat caattggtgg ggtatgactg ggcacagagg ttcatgtctgtaatccgaga
63781 ccattgggag gccaaagtgg gaggattgct tgaagccaga gtcagagaccagcctgaaca
63841 acacagcaag acctcatctc tattaaaaaa aattaaaaag tggtggagtaatttaaaaac
63901 atatttgcct tcagttggta gctcttaatc gctataaaag tttgatattggaaagtattt
63961 tgagaacaga ggcaaacaaa atggcttcat ggttgtataa ccaatagtttatgtcctttt
64021 ccaaaaattc tattttaggg gaaatatggg ataagtaaac tagtatacttaggaagtaca
64081 ttatttgtaa tgcagaattt aaaaagtcaa cagtattata ggtaagctactaactcatca
64141 gaaacaaaat tccagaggag agttaaaagg gataggaaat attgactttgctgaagaaag
64201 ttcagaatga gtcccagttg gtgaaaaata gccttgtatt ttatgtagctgcagccacga
64261 cattactcaa ggttgccaaa tagtccgcct gaaaaggacg tttgacttgaatctaaaacc
64321 atagctgtct tctcatatgc aactcagttt taaagaaaaa taaaattatatttatatttg
64381 cattgagagc acaaaaatgg cccatactat agagaatgaa catgactctctctgcacatc
64441 ttataaacat tcatatatta aattaccatt ttcctaagaa agaaaaaccaaacattagtg
64501 ttgtgggata ttggtgtact tttaataaag cataatgcta atttttcttattgcctagct
64561 atagaaatga gtttaagaaa tatccttagc ttgtcttttc aatgttatatcattctcatt
64621 cacaagtcaa tttaggatcc catcagctgt ctctttagtt atatattgaacttaaatgtt
64681 aaaatctgaa atgaatgtga gtgatttgca gctgctgtgg gctttttttatcttggtggt
64741 ttccgtaaaa cttactgatt tccctatgac ttgacaggta ttgataatgagtggagaaag
64801 actcaatgca tgccacggga ggtgtgtata gatgtgggga aggagtttggagtcgcgaca
64861 aacaccttct ttaaacctcc atgtgtgtcc gtctacagat gtgggggttgctgcaatagt
64921 gaggggctgc agtgcatgaa caccagcacg agctacctca gcaagacggtgggtattgcc
64981 cattcctgct acctgcgaga gcccccttaa tcagaagctt taactttggggatgatgtgt
65041 ttaaacttct ggttgcttta aactaacttg gttcaactca gggtctcatattttctttag
65101 gggaatgaag tcagtttttc agtgttttgt gtgtttgaca acacagtgtcacaaagaaag
65161 taattgatgc tttattactt tgcaaactct tcatatagtg gagtcaaagcctcatgcaga
65221 aaacaataaa tatacgtatg tatgtgtgta catgtacgtg tgtatgtgtgtgtgttgatc
65281 ttcaagaata aacatgttca tttggcaata aaatactttt aaatgggtgagttttcagat
65341 ggtggagata acagtgcaaa cagtattcaa agtgtaaaat taaatgcgtgtgttctgtga
65401 aacagtggta tagtattgaa ataagccatc tcactgaaga aatttattgtcttcctgtcg
65461 aaagcaaagg aaataactct gacactaaat ctcagatgtt ttgaataaactgggaagttt
65521 atctcattaa atggtaagct tctgataacc aggaaatgtc tcttaaggttggctttggat
65581 cagggatttt cagaccagac acataaaccc gctttgtggg ccttacgtggtagaggaggc
65641 tggctgtgga acacgcgtat gtgctggcga taaccatgaa agtgttgtttgaaattgtgt
65701 gcacctctgg cctctgaaca gaaatgtttg gagaaatcca gtcccgtgggctggactgaa
65761 gcaaacttct cccgaaagac aaaactgtgg ttgtcctaat gacctttctaagctattttt
65821 ggagttagac tcacacacgt aaatctggct aaattcagaa ctgttctttgacctggagaa
65881 tgaaaaatga aattgaaaga tgtggtgtta gatttgattt gtatgatgtggtatgacaga
65941 aaattcacat tttaatttta tgcaaacttt agctgatcta catggttttcagtaataaaa
66001 cctactctta tttcaatata gtattaatag aaatcagagt taagattactatctcaattc
66061 catgaactac attttttcag ctagctgaat atttccaaaa tttttactgttacgatcatt
66121 tggcctctga gtttggagac attgtcttat tatacaaccc aaattaattgctttcttttc
66181 aaaaattgag tttctttata ttgctcaccc acttgataaa gaaacaagccattttagatt
66241 aagacttgca agaagaaaca aaaaataaat tataaagcta aattttctattcagcttgcc
66301 tctgcctcaa ctctaaaggt taaaaaaaat taaaaggtga tgctttggggcctgctatca
66361 tttcttttag tatcatagtt agttaagctt agccagatgc aattcattctgattatttcc
66421 taaaagcaca gcaaaataat gtaggggtcg ttccaacatg tgttctcaaggaatacaatg
66481 tgactctaaa catagtcctg catttagaaa ctttaccaga aaaatgtacagttgtaggaa
66541 catgacaata tttcagtggt tgccaaaatt ataatatttt tgatagactaacatataatt
66601 atactattgg acatagcaaa agttatcctt agttcattta tcctccctgagtctttatca
66661 aacaacaata aacaataaga cgttatagtt ttgtacttac tattctaaataaattaatac
66721 tactttaaca ggttttattg gtattatgta ttttatcata accctgaaatcaaacaggat
66781 tctttaagat cctctaaatt ttagaactgc atactttaaa ataaattaaatagaaatact
66841 taggccaagc agatattctt tgaaaggtaa tattcatttt taaaacatattaataattaa
66901 aatgttgttt ttatcttcaa gccaaacctc ttaatgggaa ttttggtatactgagtctct
66961 tgagaaatat gtcatttcct tttaaagtta gagaaaataa atatggatgatttaggaatt
67021 gaaatataca atttttggaa tgccgttaat gatttatatt ttaaaataattcagttaagc
67081 aatatgatgt attctagatt atattcctaa tatggtattt gatttaaatcaaatagtaaa
67141 ccaaggtact ttggatactg tttccaacta ataagataac cttctctctgctcttcctcc
67201 ttccatttcc tttcttcata atcttttcta taaattactt tcaagcatattttttaaaaa
67261 catagatcca aatctatggc taggcatggt ggctcacgcc tgtggtctcagctgctgagg
67321 aggcagaggc aggaggatcg ctggagccca ggagttcagg gctgcagtgtgctaggattg
67381 caccactgca ctcccagcct aggtgacaga gcatgaccct gtttcaaaaacaaaaaaacc
67441 ccacagagct gatgtcagtc tccagcataa aggcctttca gtgatttcccattgcttgta
67501 aaataagaca aaaatctttt ttgaaggtta tatttattga catatcatagctgtacatat
67561 tttggggtca tgtgttatat gttgatacct gtacaaaatg tgtaatgatcaaatcagggt
67621 aattgggata tccatcatct caaacattta tcttttcttt ctattgggaacaatacagta
67681 cttctcttgc agctttttaa aaaatataca atatatcgtt attcactccaatttccctga
67741 tgtactattg aacactaaaa cttactcctt ctatttaact gtgcttttgtacccctcaac
67801 catcctctct ccatcctccc tacccttgcc cctcccagcc tctgataatcagtattcttc
67861 tctctacttc catgagatcc actcgtttag ctcccacata aatgagaacatgcaggattt
67921 tcaagaccac atctttatca caacctgcaa tctctgcccc atagcccctgttcagcatca
67981 tctaatgtaa tgattcttga tcttgtgctt ccagtgctct agactttctccaattcctgg
68041 gcatcatcgt gtttcctctg ctcctgggcc cttgcacaca cacctttaggttaacctggc
68101 cttcctgtct cctctttcct gaggtgctag ctcttcagat cttaatttgggtgtcaagtg
68161 gctttggcaa ggcctcaggc aagactttct gacctatttg gattagacccaatatttgta
68221 gtaaatgctt tatagtttcc catattttta aaatagtatt tattacagcctataatcaca
68281 tagtttatag ttatgtagtc attgttactt gattaatgtc tccctcctccacaaaggcaa
68341 aaacagatcc gttcactact tatcccagtg cctaccacag aatcagtgcacaaatctctt
68401 ttagtatcac ataaaaactg tggacccttt catgagaaca aatgaaaatatagacacatc
68461 cacagcattt ccccccacag ttttagggag tttgttccct gacccctagccttttccctt
68521 taaaccaggc tttaaaactg ctgccttgaa gattattaat aataaaatagctgattaaca
68581 cacttgtgga attttcaaat aattggtctt tttgctaaac aaacgtttatgctatcaatt
68641 tagcttgatc ttttaaaaaa tatctgtttc tggagaggaa cagaaaaggtaactattggg
68701 tactgggctt aattcctggg tgatgaaata atctgtgcaa caacccccatgacatgagtt
68761 tacctatgtc acaaacctgc acatgcaccc ccaaacctaa aataaaagtttacctattta
68821 acaaacctgc acatggaccc ccaaacctaa aataaaagtt tacctatgtaacaaacctgc
68881 acatggaccc ccaaacctaa aataaaaccc caaacctaaa ataaaagtttatgtcacaaa
68941 cctgcacatg cacccccaaa cctaaaataa aaccccaaac ctaaaataaaagtttaccta
69001 tgtcacaaac ctgcacatgc acccccaaac ctaaaataaa agtttacctgtgtcgcaaat
69061 ctgcatatgc accgcgaaac ctaaaataaa agtttaccta tgtcacaaatctgcacatgg
69121 acccccaaac ctaaaataaa agtttaccta tgtcacaaac ctgcacatggacccccaaac
69181 ctaaaataaa accccaaact taaaataaaa gtttacctat gtcacaaacctgcacatgga
69241 cccacaaacc tgcacatgga cccccaaacc taaaataaaa ccccaaacctaaaataaaag
69301 tttacctatg tcacaaacct gcacatgcac ccccaaacct aaaataaaagtttacgtatg
69361 taacaaacct gcacatggac ccccaaacct aaatataaac tttatatatgtatgtatata
69421 tatacatatg tatatacaga tatacatata tgtatctgta aaagaaacatatctatctat
69481 atctatatct agatatccag atgactagat gagatataga tatctgtttctcttacagat
69541 aaggaagaaa attcttcttt attctctcat tcattagtta atatgagcaaaagccaacat
69601 tatatctttc ttactattgg tcaaccaaat aaatgcatac tttacatatgggccaaatag
69661 atacctaagc ataccttagg taaaatctaa acttggaaaa cagaaaatcagtacattgtt
69721 agtaagcaaa gtaaataaat ttagtcttct attaaccatt tgagttttttctgtgaccat
69781 tgcatattca ttttctgcat tggtctaatt aggtgtcaca ttcacccagtgggtattgga
69841 gtgaaagtat ttattcaagg gtaggtgtgt atgctcagta gcataaaaattgctctatca
69901 agagggaggt gttggagagg tttaggcttt agaaattgca aggcttcgctgggcactgtg
69961 gcttacacct gtaatcccag cactttggga tgccaagaca ggcagatctcttgagcttag
70021 gaattggaga ccagcctggg caacatagtg aaaccctgtc tccccaaaaaagtataaaaa
70081 ttagccaggc atggtgttgt gcacctgtgg tcccagctac gcgggaggtagctgaggtgg
70141 gaggattgct ggatcctgga aggcagaggc tgcagtgagt aaagatcgcagcactgcact
70201 ccagcctggg tgacagagcc agaccctgcc tcaaaaaaaa aaaaaacaaaaaaaaaacaa
70261 aagaaaaaaa ttacaagggg ccaggggtaa gatgagcatt tagtgctaagtgtaagctgc
70321 atataggtga aataattttg cccagtctac ttagtactta aacatcagatatttgctata
70381 agaaaattgt ctactttaga tcacatggaa tcttttcttg ctgtatttcatctctttcac
70441 ctcccagctt tgcagaattt aggcttactt ttataataga tttacaatgttgatatgagt
70501 tttgtcaact tcttcccaat catttgcttg tgtgaaaaat caggacttgcccatgaaatt
70561 tctgaagttt gtctgctttt ttgttattgg ttgatttttt tttcagttttttttctatcc
70621 tattggtggg ctatatattt acaataatca caatatttat acattctgatctgtaatgca
70681 gtcatatttt aaaatttata tagcattagt ttttattttg tcattttaattttttaaaga
70741 tttgaagatt ttgagaatta aaaatttgta gttcatcaaa aatatggtatttctcctgag
70801 aattctgacc taagacacct tctctgcaga ctgtaactct ccttgtattttctcatctac
70861 ttttttttac ttttcccaaa cctttccctc caattcaggc ttctttcctgatttctatac
70921 tgtccactca accttgtgac ttggctgtcc ctcagacagg tcagtctgtctcacttaaca
70981 gttagaacct attccctacc accttgccca aataagcaag taagtgaatcctattctttt
71041 tccagtgttc tgtgtcttag taaatgacat catcattcag ccagtcggtcaagccaagtt
71101 attcttcctt tcaccaaaac taattgctat tcaatctacc ttgcaaacatctctaggacc
71161 tatccagtgt ctccacgctg ctaatcccgc tctgatctag gtcacatttaccccttacct
71221 agaccattcc tcttggacaa gcctaataac tggtctccta cctccattcttcctttcctc
71281 caatctattt gccacttttt agcagtgatt tttttttctt ttcttaatgctaagtcagat
71341 actgctaaaa actccttgat aacattgcct tattgggatg gagccagcattcaactagtg
71401 tggtgataag cttatctttt ctaattgggt tgcttaggcc agcatctggtcagattgatt
71461 ggtacaaatg ttctaagttg ttagtgtttt gaatggaact cttctttcagacaaaatccc
71521 ttaaacataa tttcctgggc cctcaatgat ctggatgcta cctaagtgtccagcctcaaa
71581 tgtcaatgct tttccccaca aacactactt accactaaga cccaaattcttttcacttct
71641 tgggttatgt caatatctgt cacctccagt attgcaatgc tgtactctgtgtttgaaaca
71701 tctccctaca catgatcccg tatctcgatg tatctagtta atgtctactcatccttaggc
71761 ctaaacataa atgtgacttc caggacattc tgttatgtgc ttccacagcatccattgttg
71821 ctgtatctta gcatcattac cttatctgtc agattgtttt atctttgtttaattccctag
71881 gttttttttt tttttttttt tttagatgga gtctcactct tgttgcccaggtgggggagt
71941 gcagtggcag gaactcagct cactgtgacc tctgcctcct gggttcaagtgattatcttg
72001 cctcagcctc ccaagtagct gggattgcag gtgtgcacca ccacacctggctaatttttt
72061 gtatttgtag tagagatggg gtttcaccat gttagccagg ctggtctagaaactcctgac
72121 ctcaggtgat cctcccacct ctgcctccca aagtgctggg attacaggtgtgagccactg
72181 cacccagtct tattccatag gttctagact ccatgaaaac aaagattgcgtctgcttgtt
72241 acactgaaca atagcacagt agttggcaca tagcaaacac ttagaagtgaataaaatgaa
72301 tatttgaata aaaagaaaca aatttggggt caaaggtcaa attttgaatatgctgatttg
72361 aaagagtctg aatggtgttt aggtggagat accagaaggt ttgatgtacaattctaaaat
72421 tttagaacaa taactgggtc tttaaatata gatttgggag gaagcatcattctgataaat
72481 gtcatttgaa gcctggtgtg cttattaatt cttagggtat tgatgtatcacaagagaaga
72541 gcaaacatca gtaccaaggg aaagccaaca ttcatcatta gctgtgccctgcatttccct
72601 ctttgatttt gtattatcat gcccttttcc tatccaaagg attcgcttatatttttgttt
72661 atagtataag gaattttttt ttttttgaaa cggagtctca ctcttgtcacccaggctgga
72721 gtgcaatggt gtgatcttgg ctcactgcaa cctccacctc ctgggttcaagcgattctcc
72781 tgcctcagcc tcccgagtag ctgggattac aggtgtccac caccacgcccagctgatttt
72841 gtattttaat agagataggt tttcaccacg ttggccaggc tggtctcgaactcctgactt
72901 caagtgatcc actcgcctcg gccacccaat gtgctgggat tacaggcatgagccaccgca
72961 cccggcagat agttttaatt taaattcagt tagacaagtg catgtggtacacccattatg
73021 tgacgcttca tattatgtac taaaagcatg ctatgcacaa agtgtaggtgtacagtgatg
73081 gatagatcct gccctatgga actaacaaat tagcaagcga aatcaacatttatcaagtaa
73141 ttaaaagtag tttaagtgtt gtgaaggaaa agtacaaagg cttatggaagtgcatatcca
73201 ggatgtttat aaaccaaggg aggtcgaggc ataaaatttc tgaaagcaagaatgcagtgt
73261 tcctacattt ttactaatat tccaagttct gaaaacgtgt acttaagtagcagcttttcc
73321 tgagtttatt caatttattg cattatcagt gtagtatgaa tgggagtgtgtgatgatttc
73381 cttcaaatat aaaaggaaat ttcttaatgc tgtgttttct taaggtaaaaaaaaacaaaa
73441 aaaagacttt tcgttttgtt aaaagagttc caggcacatt ttgtagcaaagccaccaatt
73501 ggcatgatgt aaattgtaag gacaatgtac cttaggtaat gttaaactcaagttttttat
73561 agatacttca tagaaatgct tttttaaaat gggactcaat gaaggggaggttatcagggc
73621 gtgtgaggaa gccagctgtt cattgaaaag taaaagcata tgcactgtgcattccaaagt
73681 atactaatgg ataaaaactg cttcaaagtt ctccacacaa gtatctaagtggctttgaaa
73741 agttaagtag attggatgtc ttttcaacct ctttcataaa catacactttgagtatattt
73801 tcttatgaga agttgtatgt ttaagagata taaccaaaaa gtagaaaatgaattttgcag
73861 ggggtaaatt atttggtgat gaaagcagaa gcagaagaaa gtcatctgcttttgaggcac
73921 acatttggat taaaagttac ttgaatgtta gtatttacct tatatattttactaaatcta
73981 ggaaagaata aagaaaaaca gctcaatctc tagagtcttc ctgaaaatggtggggttaaa
74041 tcaagctcaa ggaactagaa gttctttgct gtgttcatta gtgccagactaaagaagcca
74101 gtttagttaa gaagctagct tgctatgagc taattctgat acatagaagcagcattattt
74161 taaattctac attgccatct taaaaacaag cagctacttc tttttcattattttataaag
74221 caataatatg agcaatcaat aatatgagca tgtatattaa caaagacatgctcgattata
74281 tttaagttgg atgtttcata aaattttaca acaaaaaata tttaaacctaagtaaaatat
74341 gcaactatat aatgaaatta gaggtattat tttgcactgc agtcagagatatttcttcca
74401 ttaattaaac agaatactgc agcagtctgg aagattaatt tattacattcctttgtattc
74461 agcaagtgga acgtgatttg tattgtatct ttagcaagtt aatatttggcaagcacagtt
74521 tttggaaatc aggttttatc ctgatgtgga aaaagaactc tatgccagtaccagttatca
74581 gaactttctt taagaataac atttgcctta agaacataat taatgcatctgtgaaaaata
74641 ccactttttt ccaacccaag gtacaatgag attcacgtat tttattcagtatttctaaaa
74701 ctcttcaatt gaggttttta ttttaattgt ggtactgtgt atactttttatgcataacaa
74761 tatgttaaaa ttaattcagt accagattta aatctgttag gctatctgttattccatttt
74821 ctttcccaaa cccaatttaa gttccacagg ccttttatag ctggccatgtggttgcaatg
74881 ctaagtcaaa atgctaagac cttttcccat tttggggcat tatttctttaaattcgttgt
74941 agttttaaaa tctgatttta tagttattaa tcatattctt ctgggggtacatatatctgt
75001 acttaatgga ctaaagtttg gaatatttaa atttaaatta aatatggtagtgagatttgt
75061 tctgaagaga aactggttat atttaggata taatggtgtt ttaaaggaaggcattttttg
75121 tgtcatattt gtatccacac aaacattact tataatttag tactaaattataactcaaga
75181 tcctctcagt aaggaagttc tacacctttt tcttgaatag ccagcaagataagtacgatt
75241 aggaattgtt gctttatagc cgttgctatg ctgctgtaaa caacctattgtttcaaaatg
75301 tggctttatt tgaagtccat tcttgttggt gagaattgac tattaaatattcctattaaa
75361 gaatgccagt agattacaac tgggaacctc tcagttggaa acacttgccatttcctcttg
75421 tttattatag ttttacagaa tatacagtca gatttttttt tcagtttccaaccttgctta
75481 aatgcctttt tttatatgtc cttttgatct tctccaaaac caacaactggtattatatgc
75541 ctaaagtata tgtcaggctt cataatgaat tgtattatta caactttttttgtgtcctac
75601 attggacaca agttaatatt acttattggt tcagaacaat tcactttattgtataaaact
75661 gttttagaaa aatcataatt ttcaaaatat caaattataa tagatacattatcagttaaa
75721 tacatcatca atcagtattt actaaataaa catacttgga gctattagctagtgctgaat
75781 aatacataaa ttttatgtgc tatgaactta aatgtagaac agaaaatactattatataca
75841 caataaagca caaaatagtc tgacaatagt atcatgattc atattttcttaaaataatct
75901 acttactgtt tcaaacattg atatgtttgg atagatctaa actcttttgagaggaaattc
75961 tagttactat gttagttcag atcattatta atggcaagaa caaattgcataagggaatta
76021 aactccagtg tttacggtaa gctatttggt atttcagaaa ttctaccatagtatctctct
76081 ctgtgtatat gtatgttctc attcaccctc accgtgaggt ctctttttttttctttttct
76141 tttttttttt tttttttttt tcggagaggg agtccacctc tgttggccaggctggagtgc
76201 aggtgcagtg gtgcaatctg ggctcactgc aacctctgcc tcccgggttcaagaaactct
76261 cctgcctcag cctcccaagt agctgggatt acaggcatcc gccacgccacccagctaatt
76321 ttagtatttt tagtagaaac gggatttcac catgttgggc cggctggtcttgaactcctg
76381 acctcaagtg atcctcccac ctcagcctcc caaagtgctg gggttacaggcgtgagtcac
76441 catgccccgc cctcattgtt aggtttctga tcagcataga ggcaaggtcattactgatga
76501 ctgttatcct gagattctag caaggtgctt ggtatcatgt aggtactgaataaatagtta
76561 ctgaaaacta aacaaggaaa gattttaaat aaaaatttta aaatttagaatttctttaac
76621 aaaaatttaa ctaaatcttg gctgatgtga atgatgataa agaacaagagaaagaagagg
76681 aggaagagaa atccaaacat tacactgaaa tcaccattat tattatccctattttatagg
76741 taatgaaatg gaggcttggg gaagttaggt aatttttcca agtctcagaagtagtaaatt
76801 gaagatccag gactctaatt actgtctgtt tctcaagact aagtaaactcttgtttattc
76861 ttacatactt cgtggagtag ggaagttgcc agtgatttga aaatgttatgtatttatttt
76921 gggagggcgc catgcaagtt tataatgcac ttctaattat tattttttcagttcaaaaaa
76981 tgtatatttt ctaagcacat actatctagg aaaaaaagct tacggaaattcttagtaacg
77041 tagggattaa atatagctat gtaaaaattc acaaagtggt ctgtaaacaagaaaatagaa
77101 tttactatat ttattgaaaa ggcagtagaa actgtaatca tgtctaactgataagagtaa
77161 gtcagtcaat atacacacat gagaccagca cagaaagaat tagaaaaattaaagaggcct
77221 ctttagtatg tgacaagagc tggtataggt acaattatat cttaatacatacccagatgg
77281 catattccca gtagatatta ctaattttcc tgaagttgat agataaataaaactcaatta
77341 tcaagactct ttctactttt aatattatca aaggtatctt tctctggactcttaaaattt
77401 tttcacactg gtatcatcaa gtagcaggtc aaaatttagg gatagaggatgtgtttcaag
77461 agaagaacaa aattttttaa ctttaatttt tcaatctctg ttccttttgacaaaattaac
77521 tgaattcagc ctgccaattg ctacttagac acaaaaaaga gaaatgagacattagttatt
77581 aagattttga ttttgattcc tttatgttgt gatttccttt atttcctttaagtagttaaa
77641 ctgcaacaaa gatttttttc tctccaactg taaaaaagtc ttccattttaccacttataa
77701 aagtcttcaa cttagaggaa aagacagttc tctaaacagt gatttggttttagtgctgtt
77761 ttacctgtct ccttattctt ttagtcagtg tattcaaaaa cacatttcttgcagcctttg
77821 aaagcataga gccacactta gttttccagg aagatgcttt cttaatgtgaattagctatt
77881 cttcatctca ccagaacatt cttcaaagct gctgttcctg aattcatgcttgatacccat
77941 gggtggatcc tgatttgtga acattatcta cctaggcatg gatgaggtctctccatgatc
78001 actgatactg ctcacggcaa tctgtctacc atttggaaaa caggctggggcagaatctgg
78061 aagggcagcc atcagtggga gcaggaatga tgctgccaag ggttaggggtgggaaaacat
78121 aaactctt acaatagctg ttagttatct caaatagtgc cttaccttcactatcaggct
78181 ctgtcctgcc tggtttcact ggagacaatg ccaaatcctg ctgtgcttacttattacttt
78241 gtttttgcat tgctataaag gaatacctaa gactgggtag tttataaagaaaataggctt
78301 aattggctta tggttctgca ggctgtacag gaagcatgat gctggcatttgctcaccttc
78361 tggtgatgcc tcaggaagct tgcaatcttg gtggaagggg gcgctggtgtgtcatatggc
78421 cagagtgtga gcaagagagg gaagggagag gtctcagact cctttaaacaaccagctcta
78481 gcatgaacta acaggaaaat ctcacttctt accgaaggat ggtgctaagccattcatgag
78541 ggatctggtc ccatgaccca ttcatctccc gccagctccc acctctaacattgggaatca
78601 catttcaaca tgagatttgg aggagacaca gatccaaacc atatcagattacaaacactg
78661 tgcgtgtaag caaaattgtt tctgctggtc tgagccactt gagccctttcccactagtca
78721 catggagcac ctcttcttgt cccccgtctc cactgctgct tccttcctacagcccctgcc
78781 ctgccacagc ccttggaacc acatcgggtg ctggttatct cctgtcaattcttgttacat
78841 ttgacttccc gaagacatgt ggccctgtga ccacacacac ctgtttgaagctctcccctc
78901 tttctctggc acccgttggc ttgacagtct cccctcctga tgctccatcattgttatgct
78961 tcttcccaga catattcact agttcctttg cctcttccca cctcatagatgttcctgtgc
79021 cccaggtttc tattcttaga cattttctct tttcatttag agtgctcatcaagtaatctc
79081 atcaatgtcc aagactccaa ttacagctta aatgttcatg acttttcaatggctctccta
79141 aactctagac acacatatgt gactgcctac tagacctaaa ttcttaggtacaccttccta
79201 ccatctacat tattgcagag cttaaataat caaattataa attatacaaatataaaaaat
79261 aagtaatttt ataaatttat taaaaattgc tttttaaaac cactttgtatgtcttctgta
79321 gtgctagttc ttaatataga ttccatagat gtcttaaaag atagaaaaattgtagcttat
79381 gaagacactg cagaattctc tcttaaaata ggtatatata gtgcaaaggattactgccat
79441 tgcaatattt cacctaatca aagattttat ccaacgtgta taaacgggtatctttttaga
79501 taagaaactg gtcaaaatca taatagtggc atatgttgag gtcacatagtgaagttatct
79561 atgcagatca gacagtattg tggagaatac ctagaatctt gagaatttacacaaatagta
79621 ataacttaga tctgtatagc aaataatata catatcagat tcatttagtttatgtaatct
79681 ttataatctg agaataatga gtcaagtgtt atccttagtt tactgattatcaaagaaaaa
79741 tacagcttgg agaagtcaaa tgaattttcc aaatttatgc tacttataaatgggagagct
79801 aataaaagcc acctgtctgg gtataaccct gtacctattt cttctaaagcatattgtttt
79861 ctaaagaaag tagttacatt ttaaatgaat atataaggaa tacatcttgaatgaagacaa
79921 tatgcatttt ataatttaca tatttctgta tttcattatt cagaattcatttaaaaagtc
79981 tccttgttgg catggacaaa attggcagct aatcctatcc cataaatattttcaatggtc
80041 ttcagctgat ggcgtgaaag ttcagcaaag gccaagtcac aatgctttgaagtttgtcat
80101 cttttttatc actgctcaga ttgtcatgaa gacaccaagt aatacatggatcaattatag
80161 ttaaatgact gcaagttgat cttatcaagc agttagtggg caagatttcacttttaccat
80221 tttttctggt aatgatttag agtgtaagaa cactaggaat ttaaatctacttagttttac
80281 ttaatcaatg atgtatttgt ttatttaatt taaaacattg tttttggagaaggaagagaa
80341 cacaagaagt tcttgatcca taaataaggc gttcagaagg agaccagttaaactaaattt
80401 tgactgtaat tcagaattgt gtaaaatgcc ctactttatt ttaagctcattattttcata
80461 attcctttac caagatagca gaaacatggc tttatctatt aaattataaatgtagttttt
80521 tttgttttaa acataatcaa tttataagag atctaagaca tataaaactacattgaggta
80581 gaaatttaat aaaaattaac tttacatcta tgtaacttac gtctatgtattcagtttatt
80641 taaagtaggt cataaccaag tatttctggg ttgtgtggcc aatagctttgctcctaaatc
80701 acaaagatgt ttctgtgtgt gacacttttt aaatccctgg aatattttaaatgttcattt
80761 caaataatct ataactttga aacagttctt ttttcttgaa cacattgttctgtcacgtct
80821 aataggataa ccaattagtt ggttatccta attctaatat gcttcataactagtgacata
80881 agataaacat atggagtatt tattactctg ataaaagata ctggttaggagcaagacagt
80941 ttttactttg taatcataaa aacatagcgt cctgcgtaca ctaggcagctacttatatag
81001 agctaatctc actctttttc ggactccaat atttaccata aaagtgctttacagcatcta
81061 tataattttt tcttcttttt gtcccttctt tgtagttatt tgaaattacagtgcctctct
81121 ctcaaggccc caaaccagta acaatcagtt ttgccaatca cacttcctgccgatgcatgt
81181 ctaaactgga tgtttacaga caagttcatt ccattattag acgttccctgccagcaacac
81241 taccacagtg agtatgaatt aaatctattt tttctgcatc ctctactaatattaaattat
81301 tttcaagtaa acataagtta aacaaataac ctctgtgaaa tttactgtaatatactctgc
81361 ttcaaataca aaacaaagac aaaattttgt atagtataca atgaaaataaactgaaaatt
81421 aaaattcagt gggaagcgta ttttagaggc aaagtaattc acaatataaaagaagtatgt
81481 ctgtgaaata aaacacattc caccagtgtt cataaaatat cagtaaggtagcttaattga
81541 tttaacattc ctgaaatcag gtatgctaac tcataaatca tattaaagttcaaaacattt
81601 cagccttgat aagattttag gccaaaacaa aaagtaaata taaataattttatatctatt
81661 agcattcagt tgctttcttc aatctcaaac ataaaaatat atatgtgtgtgtgtgtatat
81721 gtgtatatat gtatctccat gtttcttatt tcagcaatat ttgaatagtgaaatagtgct
81781 taattacttg aaaaaaattt ctgttaatat catttcaaat tgacattcaaaccattattt
81841 gttattcagg tttcctttcc atcctatttt tttggagggg caaatggcagcatatacctc
81901 atgtgatcat ataggagaac ttatcacgtt ctcctgtatg atcatgttctgaccctgtga
81961 atagctgata atgaattaat atgcattact gcctaagatc tgagagttttctgccccaaa
82021 gtagggatgc aaccctttgt tccttaggat atccggtgca tatggatgaaacttacataa
82081 ctctagcatt tgtaacaaat gtataaataa attgatcaaa atacatatatattacaaaaa
82141 agaaaacctt acatttttaa aagactcaac aataaatgta atatgcaaaccatggttttc
82201 cccactgaat cacgttgtac tactctgctt agtgtggcag atagggggaccccttgtttg
82261 tccagggaca gtttaggaaa acctggaaga tagcctaatt tgagtgacagagatctgtcc
82321 ccttttatgt gagaaagcaa agatcttaca gacatttgtg aataaatgtatgctaataca
82381 agcaagagac cactaccatc tgaactcaag aggatgccgt atgtgcaatttcatccccgc
82441 aggctagaga gttctgttca ccttcctcag ccctgagcag aagccctcagtgactcctcc
82501 attctgagag ctttagccat tatctccata ctcatggctt ccaaaatgacatttgaagat
82561 ctaaccatat ttttgactta taatatttta tctaaatcta tcttctattgctttgcttgt
82621 aattatatta gctgtaagta caaagagaaa gacttgttaa atcctttatttctacattat
82681 tcatggcagt gttttctcat tttctttgag gccttgaaat cacagagttgtcattacttc
82741 ttcttcttct tctatcccat ctaaacacaa ttgattattt tggaggagggggagatatgt
82801 gttccaagct aaacttatat ttcatttcca tcactgccat tatcatccacttcattatgc
82861 atgtctctga tctaatgcag tgatattaat actagttttc aagcatcaagtctttctcct
82921 gttgtataat gtcactgttt tatgaagtaa gctttaaaag gcatcgtttcattcatctca
82981 ccagaaacag tgactttcag ttgctcaaag aactgagcac aaatttctcaccaccctatt
83041 ctggtgtcag ccttcctttc ttgttttgtc ttccattatt cacccagtctgtgtttcacc
83101 aagtccgatt cccagaacgc caagctcatt tcctgctctg tatcttgtttctattctggc
83161 cctggcttgt gttctgcctt tccaaagccc tctccatttc tcagagttcaggtaaaggtc
83221 tttctcctgc atttgtcttg tccgaatacc acggccaact ttgcttcttgaatacccata
83281 gcactcactg gattaacttc atcctcacat ggctttatca gggtctgcaaatgttgcatg
83341 tggaactgga ttatgagagt gtttccagta agtttatatt gtctgcaacattcagctaac
83401 aacactcaaa aatacttgag ccattcctgt gctctcagcc cctttacctgcattgtctga
83461 tttaaccctt aacaaaatca tctagaaggt cagcagcagc atttgccttattttacagat
83521 aaaggtggaa atcacactcc aaagctgttg gctaaataat gtacataaatgcttgttaaa
83581 taaaatgact catttcctgg atgtatttta tagcatttgc catgttttcatcattactta
83641 ttcatataac tactatccta tacactgttt gaggtcaaga agagacaggaagctacagca
83701 aaaagagcct gagtcttaga gtaagccata cctgattctg aattcagatttgccactaat
83761 tcattctctg tgatcaggta ggtgttttat gtctctgaaa ctcagtttacttatatataa
83821 actgtaaaga tgtaaagagg attgaatgaa gtactgaatg cttatgcaatgcttagcaga
83881 gtgtctggta tccagaaggt agtcattaaa gggcaaattt attattaccattaatatcta
83941 agtctgattc atttcctcac ccatgtgttt ttcagtattt ttaaaaccactatctacagt
84001 aagaaaaaca ttttatattc caaaccagga tgtgtggtat acacacacatagtgtgtctc
84061 tgtgtatata tatatgtcga tattagagaa ttttaaatta gctagataacttcacatgta
84121 attaattatg tataagcata aaactaaaac aaattaccat ttaaaaatattgtccttaat
84181 tatggtgctg ctcaagcttt ctcattatca caaccccaag gatccttttataaacatttt
84241 ttccctaatc actttcccca taaaatttta atgtaacaaa tatactctgtctttatacta
84301 tatgtatctc tgtgctttat acataaaaag gaagtgtaaa gtttacttttttgttcaatg
84361 tagtgttaaa taacaaataa aatgtttaag ttaacattta aattaaaaatttttaatctc
84421 ttaacagcta acataaattt ataattgtat ttgccaggaa acttttaaggtaatctgttt
84481 acttatataa attgtaatat atcaaattac atatgcaaag taacaattgatatgaatata
84541 taatacaaat ataataattt ataaaaacat tcaaaatcac tatttttccagcaaaagtaa
84601 aataattttt aaaataactt ctttaaaaat atttggagag cttaactattaactttgctc
84661 agtatgagaa aacttttaac ttatatagat gataaatatt aatttagatattgtcaactt
84721 tttcttttca tcatttgaca tgtaatggta tgactaacat ttgtagaattaataataaaa
84781 tataaattat tattatttaa ttctcaaagc tcaagtcaca catgaaaacaccaaggacca
84841 agcataagca atatccacag ggcaaccaat ggcagccaat aggcccacataggtaccact
84901 cagtatatgt ttgaaatcac tcagtcaatt aagagaaaat cctccagtcatagccatcta
84961 gtcaccataa tttcatagct catatattgc aaacacttgg ggtgtgttccgttgccaatg
85021 ctgttcatgt aatggccaat aaaaccaaat agaatttaag tattaaggaatattattttc
85081 ttgggttttg gagagccaaa aatcattgag atattaagat tttagccccatccaggcctc
85141 atacccaatt tttaccccct tagagatgat tttactccct ttatgaatatttgccttatt
85201 attacgtgtg atatacccaa ataatttttc tattctgttt ttctttgtgaaaatattggt
85261 ctcaaccctt tatgaattat ggcccacaat tcaataaaag ctacactagtgataatatat
85321 atatgatgga catgtgacta tgttataaaa ttctaacatt tgttaagatttaagaggaac
85381 aatcaccacc acggtggcta aaattaaaaa cactgacaaa aacaagtgttagaatgtggt
85441 gcaaccaaaa ctcctatgtc accaatgggc attaaaattg ttcaatcatttttcaaaaca
85501 gttgacagtt tcttatgaat ttaacatgta catatttcca cacaataacttgtgtacaaa
85561 tgttctttat tagtcaataa ctggaaacaa ctcaaatgcc catgaaagatgagtggatta
85621 acacatctta gtatatgcat acagtggaac attgctgagc aatgtaaaaagaatgaacta
85681 ctgatacaca caagaacata aaaggatctc agagacatta agttgagtgaaataagcttg
85741 gctaaaaaga gtacattctc tatgatttga tttacatgag gcccttaaaagacgcaaatg
85801 tactctagag tgagagaacg caattcagtg tttgtttgag gatttggatcaggattgact
85861 gacaatgggc aagagagaca ttgtgaggtg ttagaaacat tctttattttgattgtgaca
85921 gtagttaatg tggatacata aacttacgaa aagatgataa attcaaaataggagcatgtt
85981 attgtatgca aattattccc caataaaatt gatttttgaa aagcctagaaaagaattcct
86041 ttattaagta caatttttta agtagcttag gtttcaaata gtagatttctcttttttttt
86101 tttttttttt tttttttttt gagacagatt ctcactctat cacccaggctggagtacaat
86161 gacgtgatct cagctcactg caacctcctc ctcctgggtt caagcaattctctgcctcat
86221 cctcccgagt agctgtgatt acagttgccc gccaccatgc ctggttaatttttgtatttt
86281 tagtagagat ggggtttcac cattctggcc aggctggtct tgaactcctgaccttgtgat
86341 ctacccgcct cggcctccca aagtgctggg attgcaggca tgagccaccacgcccagcca
86401 aaatagtaga ttttttaaaa cctttacaat aacattttaa gtcaaatctttgattaggga
86461 gggagatttc ccacagtcat ccaaaaacta tacgttgagt cactaagataaagaatgctt
86521 ctagatccta ttagagaaaa caaagatgcg cttggctggc tctgaacttagagcacttat
86581 agtcaagtaa gaacaacaca tattatagtt acattattat tgttttattttactaaatat
86641 tacaaagcac caagcatctg ccacacattg tctcatgttc atacaaatactgccggtggc
86701 tccattcgta atacacatca catagtacaa ggctgaagag tgtggatgctgtagggagct
86761 tccagttttg agaatttagt ctctgatttc tctttgagtt tgagtaggttctgtaaactt
86821 tcttgtgaca catttttttt aatctacaaa agagcacata agtaagaatgttacatataa
86881 catcatacag aatatttata agctaatctt cactgaaatc aatctgttcaatagcattat
86941 accatatttg acataccata gccatgttaa tctgatattg tagaatagcatagtataata
87001 ataataactc ctaactcaag gatgttgtga tctttataac cagcaatccatgttaaatat
87061 tagcacagtg cctaaaacat attaagcatt caataaatga tcgctactatttttactaac
87121 atcctacaga tttggaaatt gagtcttaga aatgttaatg tgtaaaatgctaaagagcca
87181 aaaaaactgc caggaaaata taaaaattaa aatcatttta tttctgaaacccatgtgttc
87241 cccccaatat cttctaacat ttctagtatt tacagaaaaa ctttcaagtctcaatatcag
87301 aaagtttcat aaaagccaga ggaagtagca attctcttta gcagacagagttagatacca
87361 attttcatat tggtgttctc acagattatt ttttccaatt atttcctctcatattttctt
87421 caaatttaac tccatgtatt tccatgggcc ctttagtaga gactttcttttcatggaggg
87481 agtcatttgt gattaagtag cgatccccta gattttcctc cttggtagtagtgtttgttt
87541 attcattcat gagacattta tgtcaggtct tctatctcta taatactgtattaggaaatg
87601 tggggtattt ttaaatgaat aatataattc tttagctaaa ataactcatgtactagagta
87661 caaacaaaca atatttctag tatagtaagt gtctaaaaca ctatgctgtacttcattcac
87721 tcattcaaca aatagcattt gtgtttctgc tagatactaa taaggtggttagaccacaga
87781 gatagaaaga tacatagaat tgttactcca gaagaaattc cattcttgaaccagacatgt
87841 aaacatatga ctgaaatcag tgaaatcagt gtggtgagga agcatcttggagacatggct
87901 acagtagaga ggggatacat gagtctggag aggtcaacag aatcacatatgcccagccaa
87961 ggatgggctg tttcttaaag tctcttgaga actactaaaa gtatatatgcagagatgtgg
88021 tatctgcagt tttgtattat agaaagaaca gcttggtggc aagggagtgtgtggattaga
88081 ggaagcaaaa cgggaggtgg aaaaattcgg gagtaatcat ttgaaataatctgagtgaaa
88141 aataataaag atggtggcca cagcagtgga tatggggata gaaagaaaagaggtggaaaa
88201 gacgtttgaa atacaagaaa gcatatgact tgggaaccgc atatgggggatggtaaagtg
88261 ggagaagttg aggatgaaac tgtatggatg acattcaaaa gacaaggagcacctgttcat
88321 agtaggaact tacctgaaaa ggagaactga gtttttaaca catgttagcttgagtgcttg
88381 taatatttgt aagacatcag agtggtagag taattggaag agatgacctcaaccaaaaga
88441 aatatagcaa gtaagaagac aagatgagcc acagatgaaa ctgtggggaaatcaatattt
88501 aagaaacagt tatctgtaga gcagacacaa taatctggag aaacagtaatctgtacggga
88561 gactgagaag aagcaatcag aacaatcgga ataacaacag agagagagaccacaaaagcc
88621 agtggagaca tgagttcaag gaaggaggaa gtggtaagag gtgccaaatattagaaaggt
88681 tcaagaataa ctgggactta ctctgttagc tgaacagcat gaaatagagatgtttattta
88741 ctaataactt accatactct gggcacagag agggagaatg tgttttgagaaagggggaga
88801 gaaagcaaga cagtgaaaga aattcacatt tacacatgag aaactgaatcagaaagggta
88861 agtaaatttc cccaatgtca cacaactaga aaagtagcaa agcagagattcaaactaaat
88921 ttgtttggat ataatccatt tcttttgagg tgtggctatg actgcatttttattgttttt
88981 tagttgatac ataattgtac atatttatgg ggtatatgtg atattttgatacatacatat
89041 aatgcgtaat ggtcagctca ggatattttg gatatccatc acctcaaacatttatcattt
89101 ctttgtgttg taaacatttt aaatcttcta gctattttga aatatataataaaatattat
89161 taactattgt taccctactg tgctgtggaa tactagaact tgtttcttctatataactgt
89221 actttggaat gcattaccaa cctctcttca ttccccccac aactgacccacacttcccag
89281 actctagtaa ccatcattct actctctact tccgtgagat tcactttttggctctcataa
89341 atgagtgaga acatgagata tgtgtctttc tgtgcccagc ttatttcacttaacataata
89401 gcctccagtt ccctccatgt tgatgcaaat gacaggattg cattctttttatggctaaat
89461 agtactccgt tgtgtatata taacagattt tctttatttt taacttctataaattaaaaa
89521 atatcaaaca tcaaggacaa aacaaaaaca aaacaaaaaa gttcccttctaccccaattt
89581 gaaatgtaac aactattttt ttgtatttac taaagataca acccaaatccccagtcatca
89641 ttcttcactc ttcattccca gaagtaacca ccactcaaaa attgtattattctcactctt
89701 ctgtattttt atggcatctg gatttattaa cataccagaa gatattatacagtgcagctt
89761 tgagtgtttt gtattttaag ttaaaatgtt ggcattactt tttttctcttgacattatgt
89821 tttacagata tagtcatatt gctatctgta cacctggtgt attcatttaataactatata
89881 gcattccatt aaataaacac aagtttttat gtttttttta ttctgtgacgatgtactata
89941 gggaagtcaa tatacactac agattagcaa gagagtacaa tcaaagaggagagagtgatg
90001 tcaaatagac aaggaccttg aagttaatag tgctaaattt attagttatttggttagcat
90061 ggacaatgtc cctaaagatg taataaaata acacgttctg tgcacagttaataaaccagg
90121 ttgatttcag tcttaagctg tgaaagcaat tggatattaa atgaaaacacaatactgtga
90181 ttctaaagct ttgagcagca gcctagggaa tttcacctat tctgtagaggtattagggga
90241 gcagaggttg tttctgggta gaggaatgat tgacaagaca atgttcagcatagccaagaa
90301 atcttgaatt atttttaatg gataataaat atagaagata ggtattatttcaatttggaa
90361 gacagtcgcc tcgtggtgaa aaagagaaaa gggatgaaaa aagatgaggaaaaaaaatgg
90421 ataaatctag cctgaaggct aatttgcata tttatttatt tgctgtcttttatttctttt
90481 attaaaatgt tgacattgtt tactcagtaa aacttatttg cttgcaagaagttacactta
90541 ctagggttta tttaagaaga ttttattctt atgagaacat gtcttatttccaaggaatag
90601 agtaagtaga tttatagcca aggaaacatt tgatttggaa cttgaggtctccgtgttttt
90661 ggtctattaa tatttaacag atcctcagtc caaatgccta gatgcttaaatatccataag
90721 ttgtactttt agccataatg cttcactctt tcctttttaa tttgaaggttatacattatt
90781 gctttaccaa aagacaatga agcaaaatag cctaataaca taaatttaataaactgtatc
90841 agagcagaaa tggagagata gcttagcttc cagttaattg gaccacagtctcgtactaga
90901 tcatcagaaa ctactgtttt tcagcatttt aaaacatgca tctttagtctcccctgaaat
90961 tatcctcttt gccagttcaa aatctttatg tccatatacg gttatttttgaaatcgtaag
91021 tcatatgtct gttcatcccc tttcctataa agctcattat ctaaacattgtctcacactt
91081 caaaggatca cctgttgatg tgaatggatt taccagtgga actcaggcaagagattccag
91141 gctgtgagcg ttactgtttt tgtaaaggga aggtaacttt tatatatagtttgcctgcct
91201 ttggacagtc ttgtttctac cttctaaaat acgataattg aaagcacagcgttcctatgg
91261 cttgctgata gattgtgaga aataacagca aaatatatac agctgaggagattgcatcaa
91321 tacatctctg caccgaaatt atggcagtga tttgcctaga attgggggctattagatcaa
91381 agattgtcct aaagtttaaa gttacattca accaaacaca tggacaatttttgttaatat
91441 catattagac cagatttacc agttgttttc taaaatttaa tatacattttttaaccattt
91501 taggttacag aaaaagcaga aagtatagag agttttcata taacatcctctttcacgagt
91561 ttcctctagt tttaacatct tgcattagca tggtacattt gtaacagttgaggagccgat
91621 actgacatgt gatcgttaac taaaatccat agcttacatt agggttccctcttttttggg
91681 tgtaagttct gtggattttg acaaaggtat aaatgatgtg tcaatcattacagtatcatg
91741 cagaatactt ttactgccct aaaagtctcc gtgttccgcc tgttcatttctcctcccctg
91801 tattcctggc atcaaccagc cactttgatg tcatatcaac tcttataccctcataacgtg
91861 ttttttattg tcatcattgt tttgtttttg tttttctgtt aatgacgtatggctgtgaca
91921 aggtaatgag accagcggct gttgttggag gacctttttt cttaattcctggttacttat
91981 ccttgaatta tgtgacaagc tgataaatcc aataaccatg gattttccattgtttcaacc
92041 tgccaatact tctctcaagc ttgtatatcc aagaaaatat aaaaaatagtagagcagaaa
92101 attacaagct tccatactta tcctactctc cctgtgtccc catccccacttctggtggct
92161 ttccaactca gttaagtcct gtacttagcc agttggtgac cacacaatgtgacatgtttt
92221 atatccaagt cagtctcaga ctaggtgagt tttttatgtg gcagattactgcttagttta
92281 tactcagaca aaaaggaaaa aattaaacat ataaacaccc ttttttttttttcgagagtc
92341 tcatgctgtt gcccaggcta gagtgcagtg gcgtgatctc agctcactgcatcctctgcc
92401 tcccgggttc cagcgattct cctgcctcag cctcctgagt aactgggattacaagcacgt
92461 gccaccacac ctggctaatt tgtatatttt tagtagagat ggggtttcgccatattggcc
92521 aggcttgtct caaactcctg acctcaggtg atctgcccat ctcgacctcccaaaatgctg
92581 ggattacagg cgtaagccac cgtgcccagc ctaaacccat gttttaaattaatgcaatga
92641 ttgtattagc ctttcaaaca ttaagactgg caaaattgtt acaactatggagttttcatt
92701 gattcatcct actcaccatc ttttccttta atatctgaac aaaccccaactctgttcact
92761 gttctccctg tgagtagact aatggaacaa gagcaaacag taacacaaacagacgctaac
92821 acaagttcat gcagaatcaa taaaaatcag tacaacagaa gataagtctatgtgtttttg
92881 atacatacga ttaagcatgt gcctttttaa caatttatat aaaacctaaaatatatgtat
92941 ttctgatttt tacctgtagt actgaagaag ttacttaata acgttgaatataaaggccac
93001 ttttacttaa ccaccttcca ttcactatta actgctgttt ccaaagtgtaagcaaatcag
93061 tctctgtgta catagtcaag tgtatacaag cgtcaggcgt aacaaactcaagatgaacat
93121 gacagttcaa agatatttgg gacaaaattg ttgaagcatt tttacccagggctctgtagc
93181 tctgacaatg aaagaatata gttgctcttc cagctgctat tcagacagaaagcttgggca
93241 agaagggtct gtatctatgt tcttcataat acaattacaa gtttgaacttcagataacat
93301 cagcagttgg catgtggaaa accaaaaccc tattttggta tttatcaagattgttaatgg
93361 agtcaggttt cccttatttg tttctttaat ggggtacaga acatcctgttggataacccg
93421 ctgagtgaca tgacgatgct ctgaaggaat gcatgagagc ttgtggtacctgccttgaaa
93481 catgggtttc actaatgctg gtggctcaca cttcccattg aacaagactagagataggaa
93541 ggctatttga gggacacagc tatggaacca taggtgccac atggtaagccaaatttttat
93601 ttgttgtgtt gttgtgaaaa accttattaa aagagcttcc aatgagagtacttgattaat
93661 aacacagttc gtatctatag aaataatttg cttttcaaga aaatcatcatgtgctacagt
93721 tgaattgaca ttaatgttat cattcatttt gaatgatctg tgaagtattttaagagagat
93781 ctggggaagt aaatcaataa gtagtttaac ataaatcaag gtgcagttaatttttttcaa
93841 ttagaaatat attacaaaga ttctgtcatt tccaacaacg tgaaataacctggaggaaat
93901 tgtgctgagt gaaataagcc agacacagaa agatgcatat tactgatctcccttatatat
93961 ggaatctaga aaagtagaat tcatagatac agaatagaag agtggtcaccacggtcttgg
94021 gggtggggga catggggaaa tgttagagtg tgacaacttg cagttacaaggtgaatatgc
94081 tctggagacc taacgtatag tacagcatag ttactctact caatagtattctcactgcac
94141 cccccaactc ccccacacac acagtaactc tttgaggtgt ggatatgttaattagcttga
94201 ttttggtaat catttcacag tgtatacata taccaaaaca tcactttgtataccttatat
94261 atgtacaata tttatcaatc atacttcaat aaagctggaa aaatgcatgaatattatata
94321 tatgtatatg tatatacaaa tgtataagag attatagcag attatagctctttgaaaaag
94381 aataacattt cagcccagtt ctgactaaga ccaaacaaaa ggtgatagcatgttttagtt
94441 ccttaaatgt ggatttgagg agtcaagaaa tctccaagtg taggaaaacctccgtggcaa
94501 agagtgtaga atatgagaat cacaaaaata gcatgcacaa aatagcctgctgtgatgttg
94561 aaagtataag agctagtaat tattattatt attattattt ttatttttattattatactt
94621 taagttttag ggtacatgtg cacattgtgc aggttagtta catatgtatacatgtgccat
94681 gctggtgtgc tgcacccact aacttgtcat ctaccattag gtatatctcccaatgctatc
94741 cctccccctc cctccacccc acaacagtcc ccagagtgtg atgttccccttcctgtgtcc
94801 atgtgatctc attgttcaat tcccacctat gagtgagaat atgcggtgtttggttttttg
94861 ttcttgtgat agtttactga gaatgatgac ttccaatttc atccatgtccctacaaagga
94921 catgaactca tcatttttta tggctgcata gtattccatg gtgtatatgtgccacatttt
94981 cttaatccag tctatcattg ttggacattt gggttggttc caagtctttgctatcgtgaa
95041 taatgccgca ataaacatac gtgtgcatgt gtctttatag cagcatgatttatagttctt
95101 tgggtatata cccagtaatg ggatggctgg gtcaaatggt atttccagttctagatccct
95161 gaggaatcgc cacactgact tccacaatgg ttgaactagt ttacagtcccaccaacagtg
95221 taaaagtgtt cctatttctc cacatcctct ccagcacctg ttgtttcctgacttttgaat
95281 gattgccatt ctacgtggtg tgagatggta tctcattgta gttttgatttgcatttctct
95341 gatgaccagt gatggtgagc attttttcat gtgttttttg gctgcataaatgtcttcttt
95401 tgagaagtgt ctgttcatgt ccttcgccca ctttttgatg gggttgtttgtttttttctt
95461 gtaaatttgt ttgagttcat tgtagattct ggatattagc cctttgtcagatgagtaggt
95521 tgtgaaaatt ttctcccatt ttgtaggttg cctgttcact ctgatggtagtttcttttgc
95581 tgtgcagaag ctctttagtt taattagatc ccatttatca attttgtcttttgttgccat
95641 tgcttttggt gttttagacg tgaagtcctt gcccatgcct atgtcctgaatggtaatgcc
95701 taggttttct tctagggttt ttatggtttt aggtctaacg tttaagtctttaatccatct
95761 tgaactgatt tttgtataag gtgtaaggaa gggatccagt ttcagctttctacatatggc
95821 tagccagttt tcccagcacc atttattaaa tagggcatcc tttccccattgcttgttttt
95881 ctcaggtttg tcaaagatca gattgttgta gatatgcggc gttatttctgagggctctgt
95941 tctgttccat tgatctatat ctctgttttg aaccagtacc atgctgttttggttactgta
96001 gccttgtggt atagtttgaa gtcaggtagg gtgatgcctc cagctttgttcttttggctt
96061 agggttgact tggtgatgca ggctcttttt tggttccata tgaactttaaagtagttttt
96121 tccagttctg tgaagaaagt cattggtagc ttgatgggga tggcattgaatctgtaaatt
96181 accttgggca gtatggccat tttcacgata ttgattcttc ctacccatgagcatggaatg
96241 ttcttccatt tgtttgtatc ctcttttatt tccttgagca gtggtttgtagttctccttg
96301 aagaggtcct tcacatccct tgtaagttgg attcctaggt attttattctctttgaagca
96361 attgtgaatg ggagttcact catgatttgg ctctctgttt gtctgttgttggtgtataag
96421 agtgcttgtg atttttgtac attgattttg tatctggaga ctttgctgaagttgcttatc
96481 agcttaagga gatttttggc tgagacaatg gggttttcta gatatacaatcatgttgtct
96541 gcaaacaggg acaatttgac ttcctctttt cctaattgaa taccctttatttccttctcc
96601 tgcctaattg ccctggccag aacttccaac actatgttga atagtagtggtgagagaggg
96661 catccctgtc ttgtgccagt tttcaaaggg aatgcttcca gtttttgcccattcagtatg
96721 atattggctg tgggtttgtc atagatagct cttattattt tgaaatatgtcccatcaata
96781 cctaatttat tgagagtttt tagcatgaag ggttgttgaa ttttgtcaaaggctttttct
96841 gcatctattg agataatcat gtggtttttg tctttggctc tgtttatatgctggattaca
96901 tttatttatt gatttgcata tattgaacca gtcttgcatc ccagggatgaagcccgcttg
96961 atcatggtgg ataagctttt tgatgtgctg ctggattcgt tttgccagtattttattgag
97021 gatttttgca tcaatgttca tcaaggatat tggtctaaaa ttctctttttttgttgtgtc
97081 tctgcctggc tttcatatca gaatgatgct ggcctcataa aatgagttagggaggattcc
97141 ctctttttct attgattgga atagtttcag aaggaatggt accagttcctccttgtacct
97201 ctggtagaat tgggctgtga atccgtctgg tcctggactc tttttggttggtaagctatt
97261 gattattgcc acaatttcag atcctgttat tggtctattc agagattcaacttcttcctg
97321 gtttagtctt gggagagtgt atgtgtcgag gaatttattc atttcttctagattttctag
97381 tttatttgca tagaggtgtt tgtagtattc tctgatggta gtttgtatttctgtgggatc
97441 ggtggtgata tcccctttat cattttttat tgcgtctatt tgattcttctctcttttttt
97501 ctttattagt cttgctagca gtctatcaat tttgttgatc ccttcaaaaaaccagctcct
97561 ggattcatta atttttgaag ggttttttgt gtctctattt ccttcagttctgctctgatt
97621 ttagttattt cttgccttct gctagctttt gaatgtgttt gctcttgcttttctagttct
97681 tttaattgtg atgttagggt gtcaattttg gatctttcct gctttctcttgtgggcattt
97741 agtgctataa atttccctct acacactgct ttgaatgcgt cccagagattctggtatgtt
97801 gtgtctttgt tctcgttggt ttcaaagaac atctttattt ctgccttcatttcgttacgt
97861 acccagtagt cattcaggag caggttgttc agtttccatg tagttgagcagttttgagtg
97921 agattcttaa tcctgagttc tagtttgatt gcactgtggt ctgagagatagtttgttata
97981 atttctgttc ttttacattt gctgaggaga gctttacttc caagtatgtggtcaattttg
98041 gaataggtgt ggtgtggtgc tgaaaaaaat atatattcca ttgatttggggtggagagtt
98101 ctgtagatgt ctattaggtc cgcttggtgc agaactgagt tcaattcctgcgtatccttg
98161 ttgactttct gtctcgttga tctgtctaat gttgacagtg ggtgttaaagtctcccatta
98221 ttaatgtgtg ggagtctaag tctctttgta ggtcactcag gacttgctttatgaatcttg
98281 gtgctcctgt attgggtgca tatatattta ggatagttag ctcttcttgttgaattgatc
98341 cctttacgat tatgtaatgg ccttttttgt ctcttttgat ctttgttggtttaaagtctg
98401 ttttatcaga gactaggatt acaacccctg cctttttttg ttttccatttgcttggtaga
98461 tcttcctcca tccttttatt ttgagcctat gtgtgtctct gcacgtgagatgggtttcct
98521 gaatacagca cactgatggg tcttgactct ttatccaatt tgccagtctgtgtcttttaa
98581 ttggagcatt tagtccattg acatttaaag ttaatattgt tatgtgtgaatttgatcctg
98641 tcattatgat gttagctggt tattttgctc attagttgat gcagtttcttcctagtctcg
98701 atggtcttta cattttggca tgattttgca gcggctggta ccagttgttcctttccatat
98761 ttagcgcttc cttcaggagc tcttttaggg caggcctggt ggtgacaaaatctctcagca
98821 tttgcttgtc tgtaaagtat tttatttctc cttcacttat atgaagcttattttggctgg
98881 atatgaaatt ctgggttgaa aattcttttc tttaagaatg ttgaatattggcccccactc
98941 tcttctggct tgtagggttt ctgccgagag atcctctgtt agtctgatgggcttcccttt
99001 gagggtaacc agacctttct ctctggctgc ccttaacatt ttttccttcatttcaacttt
99061 ggtgaatctg acagttatgt gtcttggagt tgctcttctc gaggagtatctttgtggcat
99121 tctctgtatt tcctgaatct gaacgttggc ctgccttgct agattggggaagttctcctg
99181 gataatatcc tgcagagtgt tttccaactt ggttccattc tccccatcactttcaggtac
99241 accaatcaga catagatttg gtcttttcac atagtcccat atttcttggaggctttgctc
99301 atttcttttt attctttttt ctctaaactt cccttctcgc ttcatttcattcatttcatc
99361 ttccattgct gatactcttt cttccagttg attgcatcgg ctcctgaggcttctgcattc
99421 ttcacgtagt tctcgagcct tggttttcag ctccatcagc tcctttaagcacttctctgt
99481 attggttatt ctagttatac attcttctaa atttttttca aagttttcaacttctttgcc
99541 tttggtttga atgtcctcct gtagctcaga gtaatttgat cgtctgaagccttcttctcg
99601 cagctcgtca aagttattct ccatccagct ttgttccatt gctggtaaggaactgtgttt
99661 ctttggagga ggagaggcac tctgcttttt agactttcca gtttttctgttctgtttttt
99721 ccccatcttt gtggttttat cgacttttgg tctttgatga tggtgatgtacagatgggtt
99781 ttcggtgtgg atgtcctttc tgtttgttag ttttccttct aacagacaggaccctcagct
99841 gcaggtctgt tggaataccc tgctgtgtga ggtgtcagtg tgcccctgctggggggtgcc
99901 tcccagttag gctgctcggg ggtcaggggt cagggaccca cttgaggaagcagtctgccc
99961 gttctcagat ctccagctgc gtgctgggag aaccactgct ctcttcaaagctgtcagaca
100021 gggacattta agtctgcaga agttacttct gtctttttgt ttgtctgtgccctgccccca
100081 gaggtggagc ctacagaggc aggcaggcct ccttgagctg tggtgggctccacccagttc
100141 gagcttcccg gctgctttgt ttacctaatc aagcctgggc aatggcgggcgtccctcccc
100201 cagcctcatt gccgccttgc agtttgatct cagactgctg tgctagcaatcagcgagact
100261 ccgtgggcgt aggaccctcg agccaggtgc gggtataatc tcgtggtgtgccgttttttg
100321 tttttttttt gtttgtttgt ttgtttgttt ttgagacgga gtctcgctctgtcgcccagg
100381 ctggagtgca gtggcgggat ctcggctcac tgcaagctcc gcctgccgggttcacgccat
100441 tctcctgcct cagcctccca agtagctggg actacaggcg cccgccactacgcccggcta
100501 attttttgta tttttagtag agacggggtt tcaccgtttt agccgggatggtctcgatct
100561 cctgacctcg tgatccgccc gcctcggcct cccaaagtgc tgggattacaggcgtgagcc
100621 accgcgccgg gccggtgcgc cgttttttaa gcccgtcgga aaagcgcagtattcgggtgg
100681 gagtgacccg attttccagg tgctgcccct cacccctttc tttgactaggaaagggaact
100741 ccctgaccac ttgtgcttcc caagtgaggc aatgcctcgc cctgcttcggctcgcgcacg
100801 gtgcgtgcac ccactgacct gcgcccactg tctggcactc cctagtgagatgaacccggt
100861 acctcagatg gaaatgcaga aatcacccgt cttctgcgtt gctcaggctgggagctgtag
100921 accggagctg ttcctatttg gccatcttgg ctcctcccca agagctggtaattattaccc
100981 aacgtttaga atataatgta acagaacgta tttggaatac atttatcttttaatatttca
101041 aaggagagat aaatgcaaac taagatttta tttatcatta aattcattgttctttagttt
101101 gaaaaacaca tatactcata tttttgtcac gtgattttaa ccagcataaagcaatagctg
101161 ccacaccaaa gtcaagtgaa gctgtgaaaa taattaatga aacaattctgataaaagcat
101221 ctttatcctt catacaggtt ataggcagga ttgtggttgt gcctgtgtgtgtgtgtggtg
101281 gggtcggtgg ggggatagga aagttagttt attcacatga ttctcaacatagacatacct
101341 tgcaaataat tgtgcaattc cctgctttgc tttgcagaca gaatgtctttgaatcaatgt
101401 cttttataaa tacactatac aaaaaacata attataaacc tttaaagtatttatgcatac
101461 tttaatattc agaactagaa gagaaatttc tgtaaggaga aatgctttggagattaaaac
101521 gtaaaggaga taaccaaatt ttactaaacc tctatccatc atgaccacatttcctttcat
101581 tctaaaataa aaatattttg gaaatgttga ccccctgccc accatttttgcctgagaagt
101641 tttaaatgcg aagaacttgc tcctcacttt tgaagcacgg tgctttctttaggaaccaat
101701 ctgtatcaca tgcattctat tggtttgtat tttattacat atcattctattacattttaa
101761 aatgcatttc tgagcccatg tcattgattt catgattcat taatgggttgcaagcagcag
101821 ctggaataac actggcttag gtaatggcag tataaatcac atgttggtaaaatgaaagat
101881 gcctttctac caacacgtta taatggccac tcgatgccaa catggcagtgtgttacttaa
101941 accatatatc aatcaacaca gaagcgacat aaccaaaatg tttttaccatcatttataga
102001 agattatgag tttcatgcag ccaggattaa ttgcattgct attatagaacttaatataag
102061 ttgtatcata tttgatggaa ggatgctaac tatcaagagg atataaattttaaaaacaat
102121 gatactgttt tggataagtc ctgactgtct gcattttatc tagaacaatatatgttcatg
102181 attaacctag aaaataatga caaaaatgcg caatgagtag agacttgcccttggaattcc
102241 taaaattatt aggaaggtac aatgttctcc aagaaatatt ggtaagtgaaaaaaacaagg
102301 tttacaataa tgtgtaacgg atgctatctg tgtaacaaaa tgtgaaaaaacatatatgca
102361 attttttggc aagaagatac cctgaaaaca taaaccaaaa agccaaaaaaaaaaaaagaa
102421 acttgctgat gatacagaac ttctctgact gtacattttt ctcatagtcttaactctgat
102481 aattacatac atgtttgaca ttctcaaaag taagaacata gaagtacataatatatgcag
102541 gataaagcaa ataacagttt atgtgaagat tgttagaagc caaggttttcatggaagtta
102601 ttagtatgaa gtcaaagtag tacattaaaa tccagtaatg ttaattggatttggaagtaa
102661 cagtatgaaa ttttttctct aaaaatgtgt gcaggaatct cttgcttaagatcagtaatc
102721 tattcccaaa aatagatttt gagagcacat ttctgttcta aatgggaacaattatagtga
102781 atggaaggta aaccaaaaca tagctatttc ctacaaaata attgatacctaataatgcct
102841 gtagaaaagc atagaaaagt gacaaactct cttgataaaa tctaaaatgtatattgtttc
102901 ctaatcagca attattgatg ttgctaacat acagttgctt tgtatctagttacatggacc
102961 gtgtatatgc tgtatgagaa attgtcactt tgtggtatag catagcaaataacacagcaa
103021 tcaaaaagtt aaaagtcaaa attaaaataa ataaaagacc cataatagactgtttttcac
103081 cttgctaaag gagaaatgac tcttgaagaa actcaagaag ggacaaagaaaggtcaaatc
103141 agtcattgct atttgcagaa ggtgatgggt ggatggagga caagggggcaatcttcgaca
103201 aactgtcata tgaagaggaa tgaagagacc ttccccatgt ctgtgtctagtagatgctgt
103261 agagacttgc tggacaggaa agctttggta aatcttcaga aatgatgttcaagctgaagg
103321 aagatgttca agctgcattt tggttgcaaa atgcagattt gcttgtttttctgttgaaaa
103381 attcctctat gtgatgctgt aagagttacc aggctattat taaaagaaagatgtattgtc
103441 acactgagta tgtctgcaaa actttcttag taactggcct gtttgtttatactcaatgca
103501 catgttaaga tggctacata ggattcttac tatgttctat caatttggaatgtaactcaa
103561 cattcttcca gcacataaag ttgtttacaa tatataatga gtgtgaaagatataaataaa
103621 tacttctatt tgatgtctac accaacatta gatgaaaaaa tgaggtagtgagaagttgat
103681 atatatcctg taaattagca tatttaaaac caaaaatcct tctactgggtaaatattaac
103741 taggaaaaca ttctacagga tataatgcat ttttctagct ctgccccctgaaaaggtcta
103801 gtagtaatgt gatctgatgg cactaaacac ttctgatctc aaatgatagcctctaaaatg
103861 ctgttttcca acaaagagaa ttagggctcc tgaagaaatg gctgatgccaggtgtggagg
103921 agaaaatgag caagctgagc ttgtgatata tgttcacccc agagagggctcatgtcacgt
103981 gggcaccaac agagaggggt ctcaggtagc aacagtgggg ccattggaccatcaaaggag
104041 caattagggt acttgactga agcctgtagg ttcataattt ttactctaaaacaaggaagg
104101 aaggtgggaa gaaaggggaa aggaggggaa gggaaggaag aaaggagggagggagggaag
104161 gaaggaagta aagagctaga acaacaatga aacaaaatat ctttgataactttttggggg
104221 agtacagagt ggaaattttg catttctgga ggctttacaa gatggggatctgtgcttcag
104281 aaataagtca gtaaagatac atttacatag atgtttcctc cagtattgcttggaaaagcc
104341 aaaatcaaag tgatgtagat agttacctaa gagatgaata aaataaataatggtacatct
104401 tttgtatgga atattacata gccactaaaa ataatggagc agaactctactcaatgacat
104461 ataaaaatgt ccatgatata ttgtataatg gaaaaaaatt ttaaagcaaaaggttttacc
104521 ttatttattt cacaagctaa aaccctatat gattatacaa accaatgtgtttgccttaaa
104581 aagataaaag tctggtgtcc tctaagacca taccacaaac agtgatcacctctgggattg
104641 gaattttata gcagttgtgg gtagagagag tttgggagaa aacattcacattttatctca
104701 taattcttat atttttaaag cttttctatg agcattattt tgatacatatgtgagcagag
104761 atggtccctt ctaggtacca gttacaccat tgctaaacct cgtctgtttcttccaaaggt
104821 gtcaggcagc gaacaagacc tgccccacca attacatgtg gaataatcacatctgcagat
104881 gcctggctca ggaagatttt atgttttcct cggatgctgg agatggtaagcagaatgatg
104941 ctttaaagac taaacgccag gggtctatat tgtgattaac atactctaatattaaaacca
105001 cacatataat attcatcatt cttctaaata agtgactaaa aaatagtacattttctactt
105061 cacgttggta ttattttgaa ctcctttata aaggaacata ctcatgtttgtacccaatcc
105121 tttgatggaa aacatacaaa aggaagatgc ttttaaaagc ttttgtttcatgccacaccc
105181 agaaccaagt aaggtatagt aaagattctc tgactatttg tctagactcaacagatggat
105241 tccatgacat ctgtggacca aacaaggagc tggatgaaga gacctgtcagtgtgtctgca
105301 gagcggggct tcggcctgcc agctgtggac cccacaaaga actagacagaaactcatgcc
105361 agtgtgtctg taaaaacaaa ctcttcccca gccaatgtgg ggccaaccgagaatttgatg
105421 aaaacacatg ccagtgtgta tgtaaaagaa cctgccccag aaatcaacccctaaatcctg
105481 gaaaatgtgc ctgtgaatgt acagaaagtc cacagaaatg cttgttaaaaggaaagaagt
105541 tccaccacca aacatgcagg taagagatcc tcatgaagaa tattaatttatcttactaga
105601 aatatgctct aaaccaaaag cagttttctt aaccaaagta acaattgcttgttagaatga
105661 ggccaataca ttctgaaaga caaaaatctt atattttttt aaccaatgctaaacttgcat
105721 gagactggat ttgcttccaa aaaagcaaga caggagccttgaggatcaaaattagatcca
105781 agctcagaat atactctaaa ttagtggttc ctgtgggatg ttttcaaaatacctaaaggc
105841 aatccacttc acccccacca aaaagtagga tgccttcaga cataatttaggacaactgtt
105901 ctaaatgcag acaattttta tgcaaaactt acaaacaaag gacaggagagtaccactggt
105961 atagaattat atctggaaat gaaaatacat agctaagtat ttgatagaattagagaaata
106021 aatgaatatg ttgttaaagg tacccaagac tcatgtctta aacttggttttgactcttct
106081 gcatcaagaa aaaaaaaatg aagttattcg actcaagcac attcagtgttaatcccgaaa
106141 cctcttcctc tttaatctca gagaataaat tgatcctact atttaagccagacctgtccg
106201 tttgacattt tctccacatt ccttcaacat tgcttcatgc cattccttctttcttctgta
106261 acttgaacat cttcaactct actttttttc cccttagttt ataaaagttcccaaatttct
106321 tctattttat tagcctctta ctgtgaagtt gagcaaactt tagcaacccaggtctgttct
106381 cttcaaagct gctcaaaaac gaggcatttg ttttcacctc tttcacctaccatgtattca
106441 accaactaaa acctggttta tggcctacag tgctatgtta aacctctgtttaacgtttca
106501 ttggcctcat agttgccaaa tccaacagag aattttgtcc ttaggtaacctgtcctttcc
106561 atggcctttt tctttaagct cacctcttct atgacatgac attgtactttcctagttgtc
106621 tacttaattt tcagaccatt tgtttttaat cactttcact ggattctctttttacatcca
106681 ttctttacat atgggtagat aatgttcttt ttaacagaaa aaagcttgtatttcatttat
106741 ttactatctt cactaatgtt cattattatt tttccacagt atataacgagttcatctttt
106801 tattctcaag agttttgtgt ccttatttta atgtatattt ttggtggttttcctaaacta
106861 atattttagc tactggataa aaaggcttta gtggatctgg ctatctcattgattatattt
106921 ttcttccctt atactgcaaa gtacatcata ggtataattt tattttgagaaagaactata
106981 ttccaatttt acctatatat tcctactgta ataaccaaga ggacatttcaaaaatgtata
107041 tgctactatt ttcagaagga tatagatact aaatcttttt aagccttattaaactatgtt
107101 ttatattgaa ttcttattga gtgaatttag tatacattga aaaatctgaaattcttatgt
107161 ctgcatacct acttttctac agaattatat gaacacagac aatatttctatcattgcatt
107221 tctcctaata ctatacattc tttcaaaaag actctgttta ctgcaactcatcctagattc
107281 atttttctaa gtgtataatt ccaagctttg tgatataaat tggagcaaaagagaaaatat
107341 catattttga aaatatatat tctcctcatt ctctcttaat atctattacaaagtgcagta
107401 ggcagagtat atattctttg gttcattgcc ttaattaaca gcttttatggatcattaagt
107461 atcatatccc tttttagtag aggaatacca gtagtcataa ctatgaatttgcatttgcaa
107521 agtttaagaa aaattaacta gacatgcttt cttttctaga gccaaataaatgaaatgtca
107581 aaaccaaatt gtgtagggtt ttttatagca cacttttgat ttccacctcaggtcatcttg
107641 cacttttccc tttacaccta ttcccacaca ttaggcatgc tcatactccaaaatgttttt
107701 aaaagatagc tccaattctc accaggcgtg gtggctcaca cctgtaatcctagcactttg
107761 gaaggccaag gcgggcagat cacttgaggc caggagttca agaccagcccagccaacatg
107821 gcaaaaccct ggctctatga aaaatacaga aacttagcca ggcgtggccacacatacctg
107881 taatcccagc tactcgggag gctgagacac aagaatggct tgagcccaggaggcggaggt
107941 tgcagtaagc tgagattgcc ccactgcgct ccagcctggg cgacagaacaagactctgtc
108001 tcaaaaaatg aagcctcaat tcactggagc aacagggcag gagacacactgaccaattga
108061 taatttgtcc tctcaccgct actggaaact ggaagtctag gatgggaggaaggggaccct
108121 cgctgctgag tattgtcctt ctcacctccc tgccccagaa tgcctctgtttcacctggag
108181 ccaaggtgga aaggaagagt tagtcaccgt catgcagcca gctgccaagtagagacacaa
108241 gagtgagggt ggggctgctc actgaggacc acagttctgc caacatggctgggtttaatt
108301 gcctggaagt ctgggtccca tacaagtccc agactcatgt gaattctgccatgcttatgt
108361 gatcacagta agtcagcaga ccttcagtgt tcactttcag aatttctgttttatgtttct
108421 ttcacccatg aagcaaagag cacttcaaag gaactaatgc ttacaatacctcatccttcc
108481 atttgttata tcagcaagca agacttttat tttaaggctt ttccattcctcttaaatgtt
108541 gtaattctaa gcagaaacaa acttttttaa acctatgaac aatttcgtcataaaattagt
108601 aattttattc cagtctgaaa tttaaaaaca cagaaatacc ttggtagcatgatgaatcca
108661 ttgccttgat ctttaacgta agtgtgttct tgtttgttct cctagctgttacagacggcc
108721 atgtacgaac cgccagaagg cttgtgagcc aggattttca tatagtgaagaagtgtgtcg
108781 ttgtgtccct tcatattgga aaagaccaca aatgagctaa gattgtactgttttccagtt
108841 catcgatttt ctattatgga aaactgtgtt gccacagtag aactgtctgtgaacagagag
108901 acccttgtgg gtccatgcta acaaagacaa aagtctgtct ttcctgaaccatgtggataa
108961 ctttacagaa atggactgga gctcatctgc aaaaggcctc ttgtaaagactggttttctg
109021 ccaatgacca aacagccaag attttcctct tgtgatttct ttaaaagaatgactatataa
109081 tttatttcca ctaaaaatat tgtttctgca ttcattttta tagcaacaacaattggtaaa
109141 actcactgtg atcaatattt ttatatcatg caaaatatgt ttaaaataaaatgaaaattg
109201 tattataagc tg
人VEGF-D基因(SEQ ID NO:83)(NCBI登录号NG_012509.1)
1 aagacacatg cttctgcaag cttccatgaa ggttgtgcaa aaaagtttca atccagagtt
61 gggttccagc tttctgtagc tgtaagcatt ggtggccaca ccacctcctt acaaagcaac
121 tagaacctgc ggcatacatt ggagagattt ttttaatttt ctggacatgaagtaaattta
181 gagtgctttc taatttcagg tagaagacat gtccaccttc tgattatttttggagaacat
241 tttgattttt ttcatctctc tctccccacc cctaagattg tgcaaaaaaagcgtaccttg
301 cctaattgaa ataatttcat tggattttga tcagaactga ttatttggttttctgtgtga
361 agttttgagg tttcaaactt tccttctgga gaatgccttt tgaaacaattttctctagct
421 gcctgatgtc aactgcttag taatcagtgg atattgaaat attcaaaatgtacagagagt
481 gggtagtggt gaatgttttc atgatgttgt acgtccagct ggtgcagggctccagtaatg
541 aacatggacc agtgaaggta ggtgagctca atttttaatg tgatgaagttctttttattg
601 gctcatacag aggactttct ttgccctcac tatttttgaa acaatataaaaatgcagaac
661 catcctagta gtggactgga caggatatat cctgcatttc ttggtgactgttctgtttct
721 tagtcttatt aaacttctgg ccatgagtat ttgaaaatgc tggggtgggggttggttgtt
781 ttttgaagtt atggtagaac atgagcagtc tggaatcttt ttggatggagaagtttctcc
841 tcggttgcat atgcagatgg cacagtggtt ttttaatgaa acattgatttgtttttatga
901 ctgataactt tgtgggccat ttattttcag gtctttgtga gcagcagaggttagtttatt
961 cgtttggtaa attgaaaatt gcagtgcttt ctatgaacat tttctatctgcttttgcaaa
1021 ttaccaattg ctgccatcca gaaaaatgtt ttctcagaga gtgtttggttttttcgcttc
1081 ttgaaaggtg taaaattcaa cactaatcaa atctttggtt ctgtgagcaagcatcaaata
1141 gagcttaacg aacagagagt aatgcaaaaa attaaccaga atgttgctgactgctggaac
1201 aatacttagc ccaattttat gcatttcatg gattatatat attttaagcttctattttga
1261 aaatgattcg gatgtaattg ttttgactga agtggtgcta aatcattattgatttaggaa
1321 cttctggcct tgaaaagaca attaaatgtg agtttgagtt tttgtagctgttgtttagga
1381 cgtgcatttt caacaggggt gatatcgccc ccagcagggg aaaattggttcgtggaggga
1441 tgaaaaagtt ttaccctttt gatacatcac gcacagacgt acatacagtacatatggtat
1501 gtagtttaaa atacgttata cattcaaatt gcataggggg aaagtgtcttcaaaggctcc
1561 tggctggtgt tggtggcctg gcgagggtgg gggctgatat ttaaaaatgttgaacactga
1621 gctggaggtg agtgggaagt caccttgtct ggcagccagc acttttctaacttctcaaat
1681 tccaaattta catgggagaa atcacagtgt ttggctccat tttactgccaccagccttga
1741 tattggatct caaggccaga ttgtaggtaa atgggaatct gactgtaagcataggtaaca
1801 ggagaaaacg gtctgacttg tttgaagcaa gtaagacttt tccgactgtccagctttttc
1861 gtaagttcat gaaacagaaa tcctttagat gtgctgggct cctcgagttttaaaatattt
1921 ccattttcct tgtaaaacat cactttatct gatggtataa taaaggagactgaattgttg
1981 gacataagtc atattcttta ggttgctcag ctctttcaaa gagcacaagcaccaagaatg
2041 tctcaggtgt cctgggcact gtgaagtttt atttatttat ttatttatttatttgagacg
2101 gagtctcact ctgtcaccca ggctggagtg tagtgatgca atctcagctcgctgcaacct
2161 ctgcctcccg ggttcaagtg attcccctgc ctcagcctct cgagtagctggaattatagg
2221 cacgtgccac catgccgggc taattttttg tatttttagt agagacagggtttcactgtg
2281 ttagccagga tggtctcgat ctcctgacct gatgatctgc ccgccttggcctcccatagt
2341 gctgggatta caggcgtgag ccaccgcgcc cggctggcac tgtgaagttttaaatgcttt
2401 gaatgtactg ttaatatata aatttgttga atggagtaac gaaggaaagcagctgaattt
2461 gcatgtgaca gaaaacaagt tgttacacgt ggaggatgca gcattatatacttactaata
2521 cgattagcaa ttttttttca gaatatatca gaatttcctt taaaaagtgaagctacatat
2581 actgaactta tatccaccct acccctcgct caattaaatt atttctgatatgaaggaaag
2641 gattgcctat agctaaacag aagttttggc atagatatga ctgagtggtaagggataatg
2701 agatatataa tattggttat agttttcttt tttccccaac ttttaagaaaagaaaatcta
2761 agaggaaata atgtttctaa atgttaaagt tcttcttgtt aaaattaaaatgtagtgtga
2821 aaacatattc atggtggtaa tggtttaggg tggtggtatt tgaattttttgttttttttt
2881 ttttactttt tgaaataaaa tgttttattt attataagaa attcatggtcttcctcggta
2941 cttggtccat atgtatttct ttctcctcac cctcccctct tctaaccacctcttttccag
3001 aatggatggt gatgccaatt ttgctcctag gttgtcctcc agccacccccagcccagttt
3061 tcactttcta gctttgaaga ttgtccagtt ttccagctta gactagcattgcctctacga
3121 tagttctagg tatctgtgaa gatttttttt tttcctgtag caatcatgaaatagctacta
3181 gtgctctgga cgattgtgct taatgccatt tgggtgtaag gcctcctaatttcattagtc
3241 ttaccacttg tgtttgcaag gatagctgtt tggagtcagc agtgcatggaacatgtgaac
3301 tgagacaaat ctgtttgaaa atctcaactt aagatttcaa atccactgtgtatactattt
3361 agctgttaag tttctcagtc taagaagaac acgttttcct ctagaaataagcttaaccca
3421 gtacctatgc atcgttcatt aatataatca gattacggcc tagatgtggaatttatttct
3481 gtttctattt tctccagctt tttaatacag ctcagacagt catatacagttgtacacgat
3541 gtgcactgca caactctagg gtgctccatg catatagaca tatctgtatgtgacagccct
3601 aagtacaatg tggtagacac tctggacatt tggtaaataa gtatctacatcctcactctt
3661 ctctcattca cattggcctt ctggccagca ctatttctgg tttatttaataaacaattct
3721 tgtcccccag aaattctgtg agtcttctga agatgctggg gaaagccagccttcataaat
3781 cttttcaatg tcactaatga agacatgtca ctattgcaac aaaggaataccaggccatag
3841 taggctttca caactttttt ctgacagaat ttgtttcttt ctgctttatcttccctgtgt
3901 actgtctttt tttatccacc ctctttctta attacactgg tagaagaatattggtgggtg
3961 atggagtcat tcacattctg tgtaagacta gaatcagtcc aagatccacaggaatgtggg
4021 atacttcttt catgagaagc cacatggctc acaagacttc tttacatttgtgttacttgc
4081 cttctcctga aattgtctct acagtgaatc aaataacaag gactgaggtgtattttccat
4141 atttaattcc aggaagcagt cccactcctt ctccctgccc gatttccagttccaaagtca
4201 tgtacaggga agtccattga ctttgatgtt ggtcaaatgg cccagcaagcttttgtccac
4261 ttttctgtca gacacagtcc ttggcacaaa agacatctga aatacttcccattaatttct
4321 tctttattta tgaccttgta gttaagtgtg ttgaattata tgcttctatacacatctgtt
4381 ttaatccagt tactcactta taactggtga ctgaaacttt tatatcactatagcgtatta
4441 ttggtaccca ggatacaata gaatcctcaa tatcttacat cttcaatatagtacttcctt
4501 gtatgactta tttcttaaca taaaaatcct gttttagacc tgtggataaacctttactat
4561 aaatcccaga gacaatttct ggaatgagaa tatagtattt gtccacacacatgattccat
4621 gtagaacttg aggtaataag atctgggact cccagataca tttattattaccacaattgg
4681 atagaggtgc tacagaaata ggcacacaaa tgacagtaaa attgtttctgagaacatttc
4741 taggctcaac ttttttctac aacttaggat gaacagagag agtggaaactgtatataatt
4801 gggaatgtga ctgagatgag acaaagatga catggaagca tttcttcttcccttgctttt
4861 ctggtggtaa gttcactctt ctgtcttcct tgccactagt tcttgcagtccctaccaaga
4921 cactagggca ttatacagca aacacaccct gaggccccct gctactgcatcatgaaagcc
4981 ttagctggtt gtgatgtcct agttcataaa gaatctgcct agtctctcattagagctttc
5041 caatatttga caattcattc atttattttt ttcaacaggt atttattgggcaccaatata
5101 tctaggcatt gatctagggg ctgggaatga agcaggaaat aagtctaggggctgggaatg
5161 cagcaggaaa taagacaatg tttcaattct cttggaattt gcattccaagtgtgatgggt
5221 agaggcagac aatatgcaaa tgtgtaacat gtcaggtgtg ataaatgctatgaagaaaat
5281 caagtagggg gagcggatac agtactgaat aaatcagagg agacctttctgattcagtta
5341 tgtctctaca gagtcctgaa ggtaataaga gagacagagg caaccatcagtgcagtggcc
5401 atggtgggcg cagcaagttg gcttcgatgt ctgggtatta gccagggagccggtgcagct
5461 ggaggtgggg tgagtggagg ccagaagtgc agttgttgag gttggagaagtagccagaga
5521 agatcatgta aggtgtgact gtgctcccat aaaactttat ggacactaaaaattgaattt
5581 tatgtaattt tcctgcatca tgaaattaaa aaaaaaattg tttcaaccattggaaaatgt
5641 aaaaaattgt tcttagctaa caggccatac aaaaacaggc tgcaggttagatttggccca
5701 tgggtcatag tttggcaatt gtgttatata taaattatta cactgttttatcttcatcat
5761 ggtacacatc catacctgac atgttttatt tgcctgtgta tacatttattgctttgtcac
5821 cgtctactag aatacaagtt ttttgagaaa aggagctctt aattgtcttgtttactgcag
5881 catcccaatc accagtgaaa agcctgtatg taatagagta gatactaaaaacagtatttg
5941 ttgactgatt gatggactag acctcaggat ttttagatac ccaggatcaggatatgaact
6001 actgcattaa atcatctcca acatctactc tcatgatggc ttgtctgacttcatgattta
6061 aaaaaaattc taaagcattt ttaaggcagt atattcaccc tgtgctattttcctgtgggc
6121 ataggatagg gtttgtgtgg atgtatcaaa gacttctcca ctgtccttccaggcacaagc
6181 catcctataa ggcgttccct tttaggagcc agaggtatag aaggaagtcatctgagccca
6241 ttattccagc ctgttggtaa cagaaagaga gatgagcaaa gtagcatttggctgcacagg
6301 ggtctggaca aaacttcaac atcttgatgt tttccttcat ccctgagagccttagaaatg
6361 ctacctatgc tttcatttta tgttaggttg tttgtaaaat catggtaaattatggcaaaa
6421 tactctggtc agatacttta tcaggttagg ccaggatatg ctgtgaaaacaaacaccccc
6481 gaaatcttgg tggttcataa acaacagaga cttatttatt gcttataccacatgaccagc
6541 ctggttcatc tggggtcaaa tccacatggg gatgaagctg gctgagtatccgatcttgaa
6601 tgttaggaat cactatgaca gagggaggga gagcctgaga gcgcctcaccctggcactta
6661 aattctctgg cccagaagtg acacatatta cttctagttg cagccccttgacccactgcc
6721 ccatctagcc acaaagggcc aggaagtgca atcccaccat gcgctcagaaggcagagaga
6781 tggaaatatt tgacaaaccg tattaatgac tgtgacacat ggtgagttcttcacattggt
6841 gacttctaag tgcttctgaa cacacctttg actgtagaat gtcaaaaacattctcaattt
6901 tacagcagtg ctggaaaatg aattgtattg agacaacttg ggaggagtagaaggagatgg
6961 aataaaaaaa attcactgat ttctgtcatg tgtcatgcct cctttaatgcacggaagaac
7021 gtatactttg cttaggaaat cacattacca cattcagaac aactttagtgaagatgggaa
7081 acaaccatgg ctggtcaatg gggtaacgtg tgctgaagga agacaggtttatttctcagg
7141 aggcatcttc tccctgggaa aaggaaagac acatattcat ctcagtaaatatttgtggaa
7201 tgtctaccat gtgccaggca tatgagtgga aatgatgttt ttataaaataaagatgtctt
7261 aagtatttgc atgtcttact aacagtcagg gagttcaact tggccagtgggaaggataat
7321 tttatgcctg aaactttagt aatgtaaatt tttatgctga ttctctttttgtcattcact
7381 gagtattcct aagtaactat aacactcaca tattggagat aagtattggtttcctgaaat
7441 ctaggtttgg ctaacattgc ttctggaaag agaaaataac atgtgttgaatgtccctatg
7501 gcaaattctt gctgttactt actgttccat tatggagagt gttagaaagagtgtaatttt
7561 gattgaatga atatgctaaa aaaaacaccc taaataagaa actcacaaaaagaacagagt
7621 ggaatgaaaa agtgaaaaca actttgcaat ggtgtgcttc gtttataagtacattgtcac
7681 agcaagacta gggatgattg ggcatcttag agagtgcaga ggatgttgataaggaagagg
7741 aagaggagat aagtggattt tgatatggga cactagatcc ttagggaagaaatgtgaaag
7801 agggtattct gggctgactg ccgctggcat agcaaggctg ctttgtagaagggacaataa
7861 agttttgcat aaggatcctt tttcccatcc aatggattat gctatactttagctggaata
7921 gggctgtagc agttagctat tgccacaata atgctgtgta acaaagcagtccaaatttca
7981 gtggcttaaa acatcactac cttattctca cttatgtctc caagtcagctgggagtcaga
8041 ggattaaggc tcaaggctta ggtttggtgc aggtcagccc caggtgtctctcatcctcct
8101 ttgatcagtg ggctagcagg agcatgtgct tgcaatgatg gtggaaatagaaaaacgtgc
8161 aatcatatgt gagtttcaag cctctccttg catcatgtct tgtaatgtcctattggtcag
8221 tagggctggg aaatatatcc ctccctcaga gagtcaggag tggaaatgaaaatgttttta
8281 acaatagcct aatcaccata aaggctttgg gtggcacact gggcccttgatcttggagat
8341 cagtgataga ctgtaacaga cctcagaaac cccttggggt tattcagagcatacttctag
8401 agggtctggg gttgtcttgc cattcaagcc catcccacac ccatctgcccccacatatcc
8461 taagcacagt tatgtcaagt gagaacagag gcatttgagt ggagcacagatttcaaacac
8521 ataaaggcag ggcatggcca tctcccgcag tgctagatga tctggctgggagaaaaccac
8581 aagcagtctt catcaaattg gaggatgtgg aggtcccagg catttagtcccctagtatgt
8641 ccttaaaaaa cccagacagc catgcacaca cactcacaca aatgcacacgcacacacaca
8701 tacattcaca cacacactct tttcctgcat ttgtagttcc tttcctcagtctaagtttaa
8761 ttaaacaact tggatttcat atatattcat ttaaatatag aattgcataaagaaaagagc
8821 caccagaacc accaatggta gcatgaggcc tctgaaatga aagatgagcccaccccaacc
8881 ttaaatggcc aggtttctgg atttcagaga agcaagatca gacccttggcaggttccatc
8941 tgagcagcca cagcagccat agctacagca ataattatta gcaagtgtgcgttctccctg
9001 ccctagttag tacaccctat accatcaggt gtcatctgtt ctagttaaagtcagaccgta
9061 ataacaaaac atcaaaatgt aaaatgtggg ttgttttttt ctttacacacttctaaagac
9121 atttaaagcc tgagcagata ccttaaaatt catcttctat ctgaaaatacctcctagaac
9181 cattttaaaa aggagatgga ggcaaggtgg agagaaaaag tttgtctttggttgacactg
9241 ggaaagttgt cttttaaaaa attttttaat gtttatttac tatggagttgccgtgtcttg
9301 ctcttttcaa gctcacctgt ccggcttcta aggaatatca ggggccctaaaacacagact
9361 tctaaacccc aacacatagg acacacctaa gtgtggaaag aaaggaaagaggcaggaaag
9421 aaaggaaaga ggaaggaaag aaaggaatgc aacatttatt gtgtgcctaccatatacctg
9481 accctttcct acatatgacc acatatgatc tcttcatgag ctttatgaggtgacctatta
9541 ttaacaatgc tgctttataa atgaggaaac caagccttaa ggaagtcaaataccatatcc
9601 tcagtcaaat agctaaaaaa aaaaaaagaa aagaaaaaga aaaggtagtgcctggattca
9661 aagacagctt atttttttaa cttatagagt aaaatggatt ttttcccttttggtgtgtag
9721 ttctatgaat tctaacacat gtatagattt atataaccac aaccataattaggatacgga
9781 actattccat caccccccaa aaattcactt acgttatcct tttacagtcagaccttcctc
9841 ccagcctccc aacctctggc aatcactgat ctgttctcct tcactgtcgttttgtatttt
9901 tggttcgctg tcattttggt tttttgggaa tgtcatataa atggaatcatacagtatgta
9961 gcagtttgag attggcttct ttcactcata ctgcctttga gattctaccagtgtcccagt
10021 agttcattcc tttttattgc tgagtagtat tacatcgatt gctgaaccgttcacccattg
10081 aatgacacat aagttgtttc tagttttttg gctattgtga ataaagctactacaaacatt
10141 catgtacatg tatttatgtg aacataaggc ttcatttatc aagggtaaaatccccagaag
10201 taggactgtt gggtcatatg gtgagcatat gtttataaga aactgcaaacacattttcca
10261 gagtgttata ccattcaaag ccagttttga acaattcaaa tctatgctttttctttccag
10321 taagctgttt ctccagacga cagagtggtt tactatatta ggcaaagcttcatcttgggg
10381 aatgttattt ccaactgaga gctatgggag gcaaagtcac aaaccttcagctcagactca
10441 ccaatctaac ttgatctggg aagatacctc gacaggtggg ggagggagaacatctgctga
10501 ggaaggccgg gagtggagtg agacattgct acttggaccc caaaaccaggaaaaatttgg
10561 tggttttggt tgagcttgaa ccatcaggtt aaacaggaaa tgcaaaatgctcttccagtg
10621 aaacagaaga agctgctaag aggtagaggg aacatggaac tatttgtattgcaaccgaat
10681 ccacctcccc aaacccactg caaagggaaa ttgctgactg caatgtccctgaactccagg
10741 gtgagtaaga agagaaccac gccccccagg gaacacttgt aaatttttaagcaaatctag
10801 ggaaagttgt gtaaaatgtg tcccttccat aactcaccct aaagcttctgggtattctaa
10861 atatacaaat tctattcatc acaccgtttt atcaccaagc ttcctgaaggcatattgcca
10921 acacaatttg acaaagaaaa tagcaccaac agctttttaa agccttggaaggatagtctc
10981 agacccatgg ctctctagag gtccagggat gaatctagca aagctggcctccttttccat
11041 atatatagaa caagaggatt gttaatagca tgggattgga atggctcaagaaaagctttt
11101 tgaagctctt tgagaaaagt agccagggtc cccccttaaa ccttctttgctgatggcctt
11161 acagctcaaa accagcattg gaaccggcta ggtactccca aaccaaagcctcttccactt
11221 ggcatgtata tttatattct catatcttct ttcaaatacc tttcagtgttgccttttgaa
11281 aagattataa tttgtacttt tttgttgaat tcagtaggtt aaagcagtacctattatctt
11341 taattttatt ttgaaaaatt ggttggtttg gcttttgggg aatttgagaggcaatttagt
11401 ctgtcattta ggatggcatc atataaggca gccaacttca tcatgctatttagcctgaaa
11461 agcgatattg ttgatcttca accttgaaaa agtcgtacag gttgggagctgacctgcaaa
11521 tggtcaggta tcttgagata ggaaaaggat ttacaaatcc aggtcagcaagatactcata
11581 caaatatttt gaacccaagg tatacatcaa atagatttaa agactaagactatttctgag
11641 catgcatcga ctgtttgaag actagtggac ttgtatgaag ttcaggagttaacctgggtc
11701 ttgtaactta aaaacagcat ttctcatgcc ctaaattagt agtagagagacaatatagag
11761 agttcctata tagccctcac ctatcttcct ctaaggctaa cacctgggaagttttttttt
11821 aaaaaatcct gatggcaaag ctgcagccca gacccaaaaa atgagaatctgtgagattta
11881 agattcgagc atcagtattt ctttgaagct tattcccagg tagattcaagaagaagccaa
11941 gattttgaat gcctgcttta ttattttttt ttttgtgaga gctttaatggcacaaaatgt
12001 ttatagctac aagttataca tgtattgtaa attgtatata acgatacaaagtgctaacta
12061 aatagatgga gaacgcataa ccactttggc tcagttaatc caataatttccacaatgggt
12121 tcatgaaaaa cctcatctga ctggctaagt cttcaattct catttttttagaatagtaaa
12181 tatttttact gcaatcacag gaacttgttg cgctttccaa tgtgcaagtttctgcagttt
12241 tgctcttgat tctatttaca aatatcttaa gccagttttc atcaaacatatgaaaaatga
12301 agcctgcctt tttgtcccca aattgtaaat aggtgtaaat ctttttaagcatcaatctca
12361 caatttcaac agttaattgt tgaattctcc tttccaatac acgatgttttcgttcaacac
12421 aaatctgggt agtagtaaaa tgttcatccc gtgtgttagg gctacagatacatactacgt
12481 gctctcataa taaattttac tgttatgatg tattcatttt ttaagtaattttccataatt
12541 tcactgatgc tttaagaaaa agagcaacac tatgtttctt tttaacgttgaaagaaatca
12601 taaatatacc caggttcaat ggcgctactg atagaactgc tgctgaatttggaatgagca
12661 caatgcacta gctgtaagaa gtcagttttg ggtaatgaat aattttacttttccctcctg
12721 taataccaat ttcatactgt agcagtttat ctagtcagtt ctcctaactttctgtccttt
12781 ccaattttat tcaggctttt caaaaatcag tgagccatca gatttactttcttcccaaag
12841 aaattcaaat atgaatgctt gaaataaata ggttatagaa ggcaaatcaagtgttatcag
12901 gtttaagatt aagacagaaa catggtctaa taaaaagatg tccaaaattatctagacatc
12961 aaatgctaga aagaaaaaag aaaattactt gcaaaactat ttaggatatatcatctttct
13021 taaagattgc cagctatatt cttgaaaaaa agataaaaat tttcttgtttaacctgcatg
13081 ttattttcca ctataacatt aattttacaa atgttgatgt gagagagaagagttagatag
13141 tttctgcaaa ctggcaaacc tggctgtgat agtgttttta ttcaagttaacctggtgcac
13201 tttatagatt gctagcttta aaattaacag tgtgaacccc tgctttaaacccttctcaaa
13261 gtgcagtcag ccaatcaaca gtattgccat cacctgggaa cttgttagaccccactttgt
13321 caaactcatt tcctggtatg acaatgaatc tggctacagc aacagggtggtggacctcat
13381 ggtccacatg gcctccaagg agtaacaccc caggaccatc agccccagtgagagcacgag
13441 agaaagagag aggccctcag ctgcttggga atccctgcca cgctcagtccccaccacact
13501 gaggatctcc tctcctcaca atttccatgc agaccccctg aagagggaagggcctaggga
13561 gccccacttt gtcatgtacc accaataaag ttccctgtac tcagccaaaaaaaaaagaaa
13621 gaaagaaaaa agaaaaagaa atgcagcatc ctgtcttgcc ccaaacccactgcgtcagaa
13681 tctgcatttt aacaagatcc ccaggtatgc acattaagtt ttgagaggcagtactacata
13741 taaaatatgc aacagaccac acaaacctgg gcccaattgc tatttgtcagatacatgtat
13801 gtatttatta cttataaatt ccttcatcag atatgtatta cgtgcttattactttaaaaa
13861 gatgaatctg acacatatcc taccctcaaa gagatctcag tctaggaagggaaatacaat
13921 gtgttcataa ataatatagt ctaagttagg gacttcataa aatgcttgatggaagaagtg
13981 gcatttattt tggacctgga atgagaactg aaagaagata ttcaaaagacaagtgatgta
14041 gtgatgtagt tttgaataca cgaataatct cagggttact ttttctatagcttttggtga
14101 atcaagttgt ttattcatac atttaataaa tatttattca gctcttactattgctataag
14161 acagatacca ttactgctca ggtggttttt acaacctagt ggggaagacaagcagataac
14221 aagaaatgac acaattcatt agtgttactg gtagcgttgt gaaggacaaggatggggtgc
14281 tagaaatcca tgtgacggac cagacctagg caggggtggg agttatggaggaggtttccc
14341 tgagtaggta acatctaagc tgagaaagat ttagttagac aaagagtgaatggcattcca
14401 ggcaaaggaa acagcatgga ctaaggtcaa aacaagaaga aatgaacgaaagagcaagtt
14461 gataaaatgg atgtccaata atattccatt gttcaactat gcaacatttttcattgcctc
14521 ccaaattgga tcaaagtagc ctggtcttca tgcctccagt ccttcctctttttaaaaatt
14581 ttatacaact atattaatat agaatttaca tactataaaa tttcattcaagtatattagg
14641 aaatttactg agttgtatag ctatcatcca tataaggtcc gttatgtccctttgcaatga
14701 accctccatt ctcactccca gcctcaggca gccaataatc tattttctgtctctaggggc
14761 tggaaactta ggattggaat tagttggttg tataataaat ttagcttattagagaactgc
14821 tgaactcttt tccaaagcaa caatacaatt ttacagtttc atcagccttgtgtgagggtt
14881 cctgttgctc catatccatt acaacacttg gtattgtcag tccttttgtttatagccatt
14941 ctactgggtg tgaagtggta tctcatttca ccagcccctc ttcctaacttatttgccaga
15001 ttccccactt ctaaacttgc tctatgccca accaaagtga accccttgctgttttttttt
15061 tcccctgagg ctcgttgata tccccaaatt atgcctttct tcattctttgaatgtgttac
15121 ttgactggat atgtattttt ggtgaaggag aggggctgga aattgagagatgaaattggt
15181 aggagtacag aaggccgttg acttcctcac aacgtgggac acttccaagtttctcctaca
15241 aaccccacca ctataccttt ccaaatatct tgcctgccat cttggtcacccgtgacctaa
15301 attaatactt aggaagctat ggagatgctc atgcttcctc aggggagaatgctgtgtgaa
15361 cttagaaatt agcaaaaggg gaaatgacta cccttgaaat tgtaccacagaaaggagcat
15421 acattcaaat gatggtgaag tcttattaaa aagactttaa gcctcccaatttagaagctg
15481 gcttgtggta gccaagaaat tagagaatga tttgttattt aagagtgaaattgctagtag
15541 tcttgaatta attaccataa aaaagctgcc gctgtaataa aaagcagagatctggtaacc
15601 ctgcttcatt cactttcttc ctcttgatga aaacctttta attattttgattttgattag
15661 cacttccatc agaaaatagg aagaaattag gagcaattta cttggcaaaggtttagtaat
15721 taaaaccact gaaatcaatg gtttaagtat gtatttggga taaacacatttttaattgtt
15781 atttttgtct tacccaagtg gataacataa agttcattat acaaaaatcaaccagtgcag
15841 aaagccgatt gggaacaaac aaccattctt gaaccctttg aaaatgtatgcccttgatga
15901 attacttgtc aggtttctac ttaagtttaa ttgttagtac ttccacttaaaatagcaaaa
15961 tgactgtctg caatttctgt tatttcaaac taggttttaa attctggggttgaaagtaag
16021 cttaaataac tctgagtact tgagtaaaca ctgcattttt tatgatgaggcaagttgtat
16081 gagccattta attactttaa ttcaatccag agatttgata ttttctcctgagttctcaca
16141 gttggatagt ttaaaaatat ttctaagatt gaattgaatc ctgtaagaactataataaaa
16201 ccatacatct gcctgttttc tttctttctc tttctctcct ttcttttctttctttctttc
16261 tctttctctc ctttctttct ttctctttct ctcctttctt tctttccttcttttctttct
16321 ttctttcttt tctttctttc tttctttctt tcctttcttt cttctttctttctttcttct
16381 ttcctttctt tctttctttc tttctttctt tctttctttc tttctttttctttttctttc
16441 tttctttctt tctttctttt tcaagatcgt gctccattgc ccaggctggagtgcaagtgg
16501 cgagatcatg gctcactgca accttgacct ccccaggctc aggtgattctcccacctcag
16561 tctcctgagt agctgggagt acaggcatgc accagcatgt ctggctaatttttgtatttt
16621 tagtagagac agggtctcac catgtttcca gtctgatctt gaactcttgggctcaggcaa
16681 tcctcccacc tcggcttccc aaagtgctgg gattacaagt gtaagccaccatgcctggcc
16741 ttgtattttt ggataatatt gagtgaaatt tgcctcaata cataaaaatcctttcaatat
16801 gcttcaactc taaaatcttt aaaaagctgc ttggtttcat tattttcacgtggaagcagc
16861 attgtcacaa agttttattt tgaagactga attgtatatg gagtactgtccaactagaag
16921 agaatgaata atcaggaaaa gagagactat tgacaaataa gacttaatggagaagcattg
16981 aatttcaaag ctgccagaga cattagcaat tgttcagttt catctccagatttcttagat
17041 gaagaagctg tggcaagcca atttcacaaa cccgatctat gatcctcatgctccccactc
17101 ctctcactcc cacaattttg ccttgattca aactttatcg aaaagtgagaaatcacaggt
17161 atgagctcac tgagcttccc aggcagtctt gccatctaca aacccatgtcattctgtatt
17221 ttcctcttgt ttctgacagt gatcctctca tctagtcaca ctacatccacttatctctgg
17281 cacttatgtc aaaacaaccc ctctaggtcc tgccttagct ctcctgcatatgctttttct
17341 ttcttcctgt ctgttgcctc tttcccccag cttataattc tcccgcttttattaaaaaca
17401 tgcacccaca gacacacact cacatctgga ttcccaagtg cgataaccttgtagattcat
17461 attttcagat cgttcttagt ccacagaata taaaattgat tgaatgatggcaaacatctg
17521 cagatgacaa tcatttacag aaatggcact aaagccatga agctgaagctgcaggactta
17581 tggatctggg ctagaagaca ggggccatca aaaatttagc ttcagttggaaatcggctct
17641 tttagtgcac tacatcagat ccatgaaaga ggaaggaaga gttactgctcattgctgcct
17701 ggagctgtga cttctatgaa attacttaac ggggcaaagg aggaagcagatacttccttg
17761 caactaggac gtgagctgag ctgatccctg aatcataaat actcaacaagattcggattc
17821 aggacccagg gtattatggg gtacaaccat aaaacttcta aatgttggagaaagaataat
17881 gagaaagaaa aatgaatctc tgaatgaaaa tggaactact aaccaaaattccaaatcacg
17941 ttaatataat tattactaag aatgacagca acaaaatgaa taatcagtatatgtcatacc
18001 tataaagtta aaatctaaaa taatttgaag aaatacttaa aaatatttgcaaccctcaaa
18061 gagataaaga aataatattc ataaaattga aatgacaaac taggggcagggcgcagtggc
18121 tcacgcctgt aatcccagca ctgtgggagg ccgaggtggg tggatcacaaagtcaggaga
18181 tcgagaccat cctggctaac acggtgaaac cctgtctcta ataaaaatacaaaaacaaaa
18241 ttagccgggc gtggtggtgg gcgcctgtag tcccagctac tcaggaggctgaggagggag
18301 aatggcgtga acccgggagg tggagcttgc agtgagccga gatcgcgccactgcactcta
18361 gcctgggcaa cagaatgaga ctgggtctca aaacaaacaa acaaacaaacaaacaaacta
18421 ggaagaatat acagaaatgt aacagaaagt agataggaag aagaatgaagtagaaatgct
18481 tgaaattaga aatacggtga ttgaaattaa aaccttaaca aagtaaactctagactcaca
18541 acaattggag agttggtgat tggaaagatg aaccaattaa tttacccataacacattaga
18601 gagaggtgaa gaggaaaaaa tagctaaata taaaagcaca tttaagagacatgtaagatg
18661 attaaaagcc tccaacattt ttcaaaaaag agagtagagg caatattataggtggaataa
18721 tgaaaatgat aatggctgag aatattaaag aattgagaat aaaaaagacaagtggcctca
18781 gattgaaact gccatgaagg tctctgtctc aaattctcaa ctctgcttttgtagtatgaa
18841 agcagccgta gacaataagt aaatgaatgg acatggctgt gtgtcaatacaacttgattt
18901 acaaaaacag gcaggcagca ggctaaatta ggctgggagg tcatagtttgacagctcttg
18961 atctaaagaa taaccattgt tggccaggcg cagcggctca tgtctgtaatcacaacactt
19021 tgggcggcca aggcgagcag atcacttgag cccaggagtt caagaccagcctgcgcaaca
19081 tggcgaaacc ccatctctac taaaagtaca aaaattagcc gggcatggtggcaggctcct
19141 gtagtcccag ctacttagga ggctgaggca ggagaatcgc ttgaacctgggaggctgagg
19201 ttgcagtgag cggagatggt gccactgcac tccagcctgg atgacagagccagactcggt
19261 ctcgaaaata aataaagaat aacctttgtt tacattttca tgtatatgtctccagatgtt
19321 cctcatatat ccatataagt atgtatatat gatgtacata agtgcataagtaaaaataca
19381 taagtaattt taaaagaggt tatatcatag ctgaatcaca catgacttagaccacacttg
19441 ctcttctgag tacccatttt tggacaactc tcagtgtcca ctagcatgtctaaaaaaaat
19501 ttctcctcct aaaatgctaa tgcatgatgt agattttaac tacagcttttgaggctcagt
19561 ggaggagagt gtacatcaca ctacccaatg caaagccttt taacagccccttttgctcat
19621 ctttgttttc cttcactgtt cctcgccctg cagcaggcag ctgacattcacctttccctt
19681 ccaccctcct ctctcagcac tggtcctttg cctcctccct catcccagctctacaaatgg
19741 cctcagcctg catattccaa ccacccagca aaacaaacat ctagtaactaccgggtcagc
19801 aagagaaaat cggaggccct agccatagat agatcacctt atcatttctccagcacattc
19861 caggaaggat ctcaattcgt tctgtcccaa tatacctcta catcctttgttttgatgatc
19921 acatagaatt cattgtatgc atatatcatt atttatataa ctaagcccccaattttgaac
19981 aagaggctac atactgaaaa tcttttatct accaagtctt ttttttcttacaaacccatc
20041 caatacagtt gcactgtatc cgccaataca gttcatgcaa ctgtatggaaagcaaactct
20101 agaagagtat ttgatagctc cataagaata ttaaactctt atacttctagagcgtaaaac
20161 cccagaaaag tattttgtca gaaaaaaatc atgtttttga aatagtaggttttaaaagaa
20221 aacaaagaga gttagaagta agaaaattca ggttatcagg ggcttgatatcttttttttg
20281 tgactgtagt caggttaccc aggcctttgt ggatcaattt ctcaaacaaataacagagat
20341 gaaaacaact gtcagtagct actgtcacaa aaataatatg ataaacatcttttcgtttcc
20401 tatggctgcc ataactaatt atcacaaact tggtggctta aaataacagaaatgtatttt
20461 ctcacagctc cagagtccag aattccaaaa tggaagggtc agcaaggctgcacgccctca
20521 aaacactctt ggagagaatc ttttcttgct tcatccagct tctgatggctctaggcaatc
20581 ccccgcttgt cactgcatca ctccggtctc tgcccccatc ttcaaatgaccttcctctgt
20641 gtccctgtct tctcttctgt ctcttataag gacacttgtc attgtacagtatttagggtc
20701 cacatagata atccaggagg atctcatttt aagatcctta acttcattacatctgtacag
20761 atcctttgtc caaattaagg taatgttcac aggttctgtg ggttaggatgtggacatatc
20821 attttgaggc ccaccattca atgcactaca attttctttg taagtgttctgagaacccag
20881 gaagaataag taaatcctct gattcaatca aaaatgagca gaatgtaaaccaaaaatact
20941 agaagatatc ctttttccta ggcactggca tacgtttcaa tagtatctctaattacagat
21001 gtatttacac ttctaagtgt cagaaatgaa gattattatg acaaatttaaaatttagtaa
21061 cttgttttta aactggtatt tttgtttttt taagcgatca tctcagtccacattggaacg
21121 atctgaacag cagatcaggg ctgcttctag tttggaggaa ctacttcgaattactcactc
21181 tgaggactgg aagctgtgga gatgcaggct gaggctcaaa agttttaccagtatggactc
21241 tcgctcagca tcccatcggt ccactaggtt tgcggcaact ttctatgacattgaaacact
21301 aaaaggtagg tgtgtggatg tggagacaaa ttctttctct ttattagatagtgacaaaca
21361 cacttacttt ctccaaaagt ctgcgtaggg cagacacgtg tcagagggagaatgaaagtc
21421 ggtctttgat ttccagtatt agtgcagaat cttgattttt taatgtttacttcacagaga
21481 aatatattca atatgatttt gagataaaaa acacaaaaga acatctcaaaatatagaaat
21541 aaatttaact caaggatgtg ggggcaaaga aaacccagga agactattgttctcaataga
21601 aaaacaatca tcaggtttac ttagaaaata aaacctgggg attcatccacaaggagtatt
21661 ctactgccat acatacatag acaaaaacca aagatggcca ggcatggtggctcatgcctg
21721 taatcccagc actttgggag gccaagaacg gcagatcgct tgagcccaggagtttgaaac
21781 cagcctgggc aacatgacga gaccccatct ctacaaaaaa atagaaaaaaatagctgaac
21841 attgtggtac gtgcctgtat tcccagctac ttgggaggct gaggtgggaggatcggctga
21901 gcccaggagg tcgaggctgc agtgagccat gatcatgcta ctgcactccagcctgggcaa
21961 cagagcaaga tcctgtctca aaaaaaccac cccctccccg aaccaatagattaggtatag
22021 cttttttttt tatttctgca aagttgtgtg attttttagt aaaagtgaaaagtaaaagtt
22081 agacactgag ttgtaatatt gggtactggt attgctagga gaataatgaagggagaaaat
22141 tctcaagaca aaatgatcaa aactccagac tagaaaataa cataatttgaaataaggata
22201 atgatcgttc cctagtaacg tatgaagatt ctttaaaaga aaatcaggccaggtgtggtg
22261 gatgacacct gtaatcccag cactttggga ggttgaggca ggtggatcacctgaggtcag
22321 gagttcgaga ccagcctgac caacatggtg aaaacccatc tctactaaaaatacaaaatt
22381 agccaggcat ggcggtgcat gcctgtaatc ccaactactt gggaggctgaggcaggagaa
22441 tcacttgaac ccaggaggcg gaggttgcag tgagccaaga ttgcaccattgcactccaac
22501 ctgggcaaca agagtgaaac tccatcttaa aaaacaaaaa aacaaaacaaaacaaaacaa
22561 aaaaacaaag aaagaaagaa agaaaaccag tgtgagtagg tactgtcataatgaataaaa
22621 tgcttgtcaa gtaaagttct gtggtttctg attaggcact taattttttgatgtcatgtc
22681 aaaacaacac aagaagctgc tacagcattg ctgatctagc attctagatttgattaacat
22741 gattacctgg taactgacta tatatatagc ataattcaaa ttaaccactaggccaaaact
22801 atttttttct ttctacctaa aattgtattt gttttttccc atttgtaaaaagatgttggg
22861 gttgcacaga cctctgttgt tggctgtggg gagagctgtg catagatggggacatattct
22921 ttggtagcac cttgggcatg agtgtgaaga ggattcttag tgttcatgtgtatgactgtg
22981 tgtctaagtg agttgatgtg gtaggaacca tagcctcgag ctcacttcagacagaaattt
23041 gaagctctag atgtttctat gtggtgaatt aatatagcct tcatgagaacaaagggttgg
23101 cacctcatct agaggtcaaa ggccttaacc agattacctg actgaaggcctgaggtgaac
23161 ctggagctat ttcatgaaca tgaacgttac cataaaacca agactaggtgatctaaaaaa
23221 agtcaatgac attgacattt tctaaggaga aaaccattaa aatatcacggaatttgcaaa
23281 ccctatgaat ttatctcgta atttctaggg gatcatctga agttatttactaagttagaa
23341 gcagtcaata atgaaatcag catgttacac caattagaat ttgttatcaactctcccttg
23401 tggatttcaa ggtaatttcc tgaggcagag cagtcctgct gggaagcagtaaagaatagt
23461 agagttatga agcctttaat cagtgatgtt ggtcataatt gcatatgattttgattaaaa
23521 gcttaccact ccaatttcaa aacttagttt tataaaaaga gaaaaagcaaatggaaagca
23581 acctttaagt agaattttaa attgggaata ttttcatagg ttggtttcttgttttttcaa
23641 ggattcatga ttaattatag tgaattaaat aataaccata ataatacttaattgagtaat
23701 ttatctctca tgtgttcagc cttcaggctt tttatataaa tattaataatcagaaatttt
23761 taaaaaggtt tcttgggggc tgggcacagt ggctcacgcc tttaatcccagcactttggg
23821 aggctgaggt gggcggatca caaggttaag agatcaagac cagcctggccaacatggtga
23881 aactccgtct ctactaaaaa tacaaaaatt agctgggcat ggtggcgcatacctgtaatc
23941 ccagctactt gggaggctga ggcaggagaa tcgcttgaac ccaggaggtggaggttgcag
24001 tgagccgaga tcgcgccgct gcactccagc ctggcaacag agtgagaccccgtctcaaaa
24061 aaaaaaaaaa aagtttctca ggatagaatg ttttattatg aggaaaaaaataaaaaaaaa
24121 caaagtttag gtagactgtg tagtataatg cagtgctcca gacaactcatattatgtttt
24181 cagtgattga agaagcaaca tatgaaaaaa attggtatta agggatgaaaaaggagaaag
24241 gaatggagaa gatgttataa gggaataatt tagggactag ggtcacatctcaaatggtaa
24301 tattgtatca gtatacttca agcagacgtt ttctctattc cttctattcccctatatggg
24361 aattcaggat aatctcagga gagttcttga aaatgcagta aaaataaaggagagtttgcc
24421 tattgttgca taacacatta ccacaaaact tagctactta aaacaatatttatctcagtt
24481 tctgtgggcc agaaatgctg acatggccta gatcagtttt tctgcttcagatgtctctgg
24541 aggctgcagt taagatgttg gcttgggctg caggcatctt agggcacagctgaagcagag
24601 tgtgctttca agttcagtca gctgttgttt gcaggactca attcctcacaggctgttgga
24661 ctgagggtct tagttcctcg ctggctattg gccagaggct gcctcaagttccttgtcgtg
24721 tggacctttc taacatggcg gcaaactaac acaagaactg aaaaccaaacaccgcatgtt
24781 ctcactcata agtgggagtt gaacaatgag aacacatata cacaaggaggggaacatcac
24841 aaaccagggc ctgttggtgg gtggggggca aagggaggga gagcattaggacaaatacct
24901 aatgcatgcg gggcttgaaa cctagatgac gggttgacgg gtgcagcaaaccaccgtggc
24961 acatgcatac ctgtgtaaca aacctgcacg ttctgcacat gtatcccagaacttaaagta
25021 aaataagcta aaaaaaaaaa aaaaaaaaaa agcctgcaag tggagaaggaggagagagag
25081 agagagagtg tgtgtgagaa agtgagacag agtaagaaag aagggagcttgcaataagta
25141 gaaacaagac tgcaatcttt tttaacttca tcatggaagt ggtatcccatcacttttgct
25201 gtattctctt cataagaagc aagttactag gttcagctca cacacgaggggaaggcattt
25261 acacaagggc atgactatca ggagatgggg accactgggg gttagtttcaaagctgccta
25321 ccacaagaga ttttcaccag caccacaacc ccacacataa taaataaactctacagttcc
25381 atggcaagct acaaggaagt ctttgtgttg tctttatcat aaaattgaatctttccccca
25441 aaacacctgt agaaaggcta tgcagcatta agtatcaaag ggtcaaaatctaatttaaaa
25501 aataaattat gagagaaaag caagtactgt tttacaagaa agtatataatttttttattc
25561 ccataggctt ctttttttgt taccttcaaa ttaactatgg tcaaaggattgctcattcca
25621 gtaataagaa caggcttatt tcatcattta cataaatatc agtatcgggcacttgcaaat
25681 gagaaaactc tgatttgagt aaggattagt ttcacttcaa tttccatttatgcgtttgcc
25741 aagtttaaat cctactgtag ttacttaagc aaccaacaga aacatatttcttgatgatgc
25801 taaaacctac ctacacctgg ctttaaagca gaagaaatgc tatccagctgtatcctataa
25861 attgcttgat aaataatatt tacatgttat ttctttacac gcttctatttacttccctat
25921 taaccagctt ctccagatgt attcagtgta attatgtaca ggacatggtgttctacctca
25981 aagggaaata aaatacttat attctacaag gtatggtata aatgggaaagagcacagaga
26041 ttggttgtaa cttctctgca aacaatcttt ggttaaagga ctgacaaaaaatatccatct
26101 agtaaaagaa acaagcagta gaaatgtgaa aatgactgtg ttcagcataaccctggcaca
26161 tgttggcaca ccaggaccat tccacctgct agccccagtg agctttctttctctctgcag
26221 ttatagatga agaatggcaa agaactcagt gcagccctag agaaacgtgcgtggaggtgg
26281 ccagtgagct ggggaagagt accaacacat tcttcaagcc cccttgtgtgaacgtgttcc
26341 gatgtggtgg ctgttgcaat gaagagagcc ttatctgtat gaacaccagcacctcgtaca
26401 tttccaaaca ggtataagga catcggcaag cctgccgtct ctaaagccctgatgataata
26461 gtgttgatag ctacaacaac cttgttgcta aacactgtac taaatgctttatgtgcataa
26521 tcgcatttaa tctttgaaac aaatcaagag ggtattttat gctcctttatagatgaggaa
26581 actgaggctc agagaggtaa cttacttatc caagtttaca cggctgataaatagcagagc
26641 tgggattcaa acccaggtct gtgggaggcc agagcctgaa ctcttatcagttattgtctc
26701 tctgatgcta tgatgtcaag actcagaaaa ccatatggaa gttactaggacaggatgtta
26761 aaaggaatga agatagctga tggcaggttc tgtgttgctc aaatggagtgattgagaaaa
26821 atttaatgaa ggttgtgggc agaattgggg aaagagggat gggacagtgaagcacctgaa
26881 gctagcaaaa agggtgagat ttccccaccc ttcgactgag gagacaaggggagggagcag
26941 ttatgggaac ccagagggaa agcggagaag agggtttctg gactggccactgtcaactct
27001 tagcctggca gggagtaggg gcaggggctg ggagaggcaa gagggtttatagatgtagcc
27061 catggagggc agcgtcctgg ggcacagagc ctgatgggga aggaaggggagaggatggtg
27121 tctctggagg ggcaaagaga gaatatctag cacaaaagac atttggaaataattctgcag
27181 tccccatgaa agaaataatt cagccctctt catcttataa atttccctttgcttagtagg
27241 taagttttcc tttctctggt taccatgttt ttaataaatg tcgcatatgagagcagtagt
27301 aacaaacttg ggaaagcaat actaaaaaac tgtacatcaa actacattatttttggtatc
27361 tgttgcaaat tctttgaatg ttgatatact tatttaattg tcagtttgcctatatggttt
27421 attctccttt taactgcaaa aagaggtagt acaagaaaat tacatgcactgaatatatcc
27481 atgttaggta attttcttaa tgctgatttg ttttgttaat agatttacttatccttaatt
27541 ttgttcctcc accctctaaa atatccttta aactgcagag tttctttttctaaattcttt
27601 tagagaatct tggagcttgt gtgtatttta acctctacta tttgacaattaggaaaaaaa
27661 aatgacccaa gtagggctaa gcatcaattc tgagtagaaa aaaagcttgcataacgtaag
27721 agggtttagt tcatgatcat gtgattccct agagcatagc caaaaaattgtgcaagaaga
27781 tgaagtttat gcaaagtaaa cactacaaaa acactctcac tgagactcatggaagttcca
27841 ttacatattg agatgtcaga ataaacacaa ccttaatgga ttgcttccacttaatagata
27901 gttgagtact ttattttgac tgctgtactc aacaaatgat taatttcatacaatgtactt
27961 aagtgtaagt gtacagcagt ttttcttcca aatatgcatt tttgaacattttaatagtag
28021 ttttttaaaa actatctctc gccccaaagt tatggactat ttggcaaaccacctcttaga
28081 aacaaagtga acaaatgaat actctatgta gtaaggacta catggaatggtgattgaata
28141 gacaatgcat taaaatcaac ttcaaactca tccacacatc atagaaccactcaagaaagt
28201 tgtgtaatct ctctgtacat ctgtttcttc acctgtaaga tggggataataaaaacccac
28261 cccataatgt tgttataagg ggtaaatgag ttaacatgaa agcacttacaacagggcctg
28321 gcctacggaa agcgtagaaa gaatgatata catgttagct ataattatttgtttgggcat
28381 gatgatcttg tatcagtcag ctattaatac acagtgctac gtaacaaacacactaaaact
28441 cagtggttcc aaacaacaat gatttactct cacttatgta tctgaggttcagttagttta
28501 gggtggattc agctgggctt gactctaagc tgcagtgtga gtccaagtcaacttctatgt
28561 ttcccatcgc ttggaccagc aagcctgccg gattatgttc ttttcatggctatagcataa
28621 gtttgagaaa acaagcccca taaaacatgc acagttcaaa tttgtacttctgtcatgtct
28681 gctaacatcc cactagccaa agaaagtgac atggccaaat aaaaagtcaagagacaggaa
28741 actatatttc ttcaatagag atggtgtgag aagggatgaa taaatagtttgaataataat
28801 ctattctaat aaaatcctaa agaaactgca tagctttaat ctcatttaacccttacgatt
28861 tacactcaaa tttaaagcag gagcagggat taacagtacc attttacaagagtatcaatg
28921 atcaaaaagt taaaagattt gaccaaactt aaacacttca taaagttagatgagcctgtt
28981 tagttccatt cttaatggac aacttggcta aagtcattgc cgtaaatgacaaaggcaaaa
29041 attcagacta gaacaacttt aaaaatgata tataaaatta aaaaaatatattgtggttat
29101 ctttctctgc tgtagctctt tgagatatca gtgcctttga catcagtacctgaattagtg
29161 cctgttaaag ttgccaatca tacaggttgt aagtgcttgc caacagccccccgccatcca
29221 tactcaatta tcagaagatc catccagatc cctgaagaag atcggtaagcacttttgttt
29281 ttttttttat actggattat gcttattttt gccttgccaa aactgtgtgtagaggatttt
29341 tcattaatgt agagttatca atttatcttc aaattattca tattttagcttctaacctga
29401 acctactggt aataactggc aaatacatat ttttattaga tgttagatatatattgtggt
29461 aggaccaaaa cgctcagtgg tatgagcttg tcatgtctac ttgtagacacgtttgttctt
29521 aatatgcata gtctactgca ggtgtaaaac cgctgtaacc tcaaatttagcacatgttcc
29581 agaacaagca ttaaataaaa cttatttcag gctgtttgta tatttacatcctgaaatgag
29641 agaaaacaaa gaagattcct ggggtcattg gggagtgaca aaactagcagcacgtgagtt
29701 ttgcaacttt ctaatctttc ccccttaaga ttaccaaatg gaaaacccttattttaaatt
29761 aaaatgactt aaaattaatt tggctttgaa attctcttga gattaattttgtgattattt
29821 ataagacaaa cgacaaaacc aaaggtaagg atcacttatt tgaagaaaaaaaaggattta
29881 atataaagaa acaagtaaag ggtaactgaa tgaaaagatc attagttagatacttagact
29941 ttgcaaaagt aaagcaataa atatattgtg tgagtggcaa gtaaaagagtaagctggtga
30001 ttagttaaca ttgaaccaag aagacacctc ccgcctctct ccagcagaaaagaaaacttg
30061 tagaaaagca acatttattc tcaagatgtt cctgctgttc tggccaatgcttttatcttt
30121 attttaaaga aaataatctt aggggccggg cacggtggct cacacctgtaatcccagcag
30181 tatgggaggc tgaggcgggc agatcacgag gtcaggagat tgagaccatcctggctaaca
30241 cggtgcaact ccgtctctac taaaaatata aaaaaaaatt agccgggtgtggtggtgggt
30301 gcctgtagtc ccagttactt gggaggctga ggcaggagaa tggcatgaacctgggaggtg
30361 gagcttgcag tgagccgaga tcgcgccact gcactccagc ctgggcaacagagggagact
30421 ccgtcaaaaa aaaaagaaaa gaaaataatc ttaggaggta tgttagaacatatttaattt
30481 tcgtaaataa actgttgaca gctataattt gcatagtttt aacatataccttcttaagaa
30541 gattacaatt tccaaaatta cagtttagtt tctaaacatt tccacgtagaatatttataa
30601 ttacagaatc actatctagt aagatgcagt tcataaatac aaattaagctcctttaaaat
30661 cttttttttt tttgagacgg agtttcgctc ttgttgcccc ggctggagtgcaatggcgag
30721 atctcggctc actgcaacct ccgcctccca ggttcaagtg attctcctgcctcagccttc
30781 caagtagctg ggattacagg catgtgccgc cacgcccggc taattttgtatttttcagta
30841 gagatggggt ttctccatat tagtcaggct ggtctcgaac tcccgacctcaggtgatctg
30901 cccgcctcgg actcccaaag tgctgggatt acaggcgtga gccaccgcacctggcccgct
30961 cctttaaaat cttaactctt ctcacatcct tatcattttg tggtgagaacatttgaaatt
31021 tactctctta gcaatttgga aatataaaat acattattat tattgactatagttaccatg
31081 ctgtgcaata gatctcaaaa ccttatttct ccaaactgag tataaaaagcaaaaaataaa
31141 tttaaaaaat cttaactatt atctactcag gaatttattt aatgttccaaagttttgatt
31201 atccttgaaa gcttttaaat ctggttcatt gttttctttt cctagctgttcccattccaa
31261 gaaactctgt cctattgaca tgctatggga tagcaacaaa tgtaaatgtgttttgcagga
31321 ggaaaatcca cttgctggaa cagaaggtaa tgatagtagt agtaaaataataacagtaat
31381 aataaaagta gcaacaatag cagcaaccgt tattgagtac ttagtatgaccagacaatgt
31441 tgtaaatctt gtatatgttt taactcattt aattctcaca acaaccctgtaatgtactat
31501 tgttatttct ttttttacaa ttacaaaatg ggcacaccaa gatatcgagtaatttcctca
31561 aggtcacaca gctgagagtg atagaagtgg tcagattcca gaaccctctgtaccataatc
31621 atatagtaag tccatcaatg catcactctg ctttttaatc tcaaagaaaagcccagagtg
31681 gttggagcat cctgaaacac tgaaattgaa aggggatgtt aaacttgaatgaaagctgct
31741 tcagaactaa atactagtca actgcagttt actaatttat ttgtataaaagtctcacagg
31801 aacataaagt aattttggac ttggtttctg tcagctgcat catatgaaaacacgccagta
31861 atttgaaaaa agaaatggag aataagagaa aatttttctg gaattagggcaaagcaaaag
31921 caaaatatgg ctattggtct aaggggagct gggagcaaaa tgagatatagtcaaattgtc
31981 attgctcata atccgtaatt ctgtgacttt gggtgatgaa catttgcttgaaaatgaatg
32041 cattttaatg tattttccag agagctttac atggttccac caaaaaaaaaaaagaaagaa
32101 aaaaaaagtc acaagtagtc atgcagtttt aaccttgctt gttttaaactataatctata
32161 agcaagaaca gtaagggcta aactctaaga aatctgtcct ataaactgtaaatagcaacc
32221 tactctccat tcttctgcct ctcagcttcc ttctaaatgt tttcacgaaagctcagccca
32281 gagcatgtgg ggaaatttaa tatttatgtg gtttaaatgc ccatgccgatcttgaatgtt
32341 ctttacaccc ttcccaccaa gtgttcagcc atcctctacc agaacatacatcagttattt
32401 ggagactcgc catccagtga ggcagcacca aggggtgggc acactcctgttgttatactg
32461 aaatgaaatc tctctccaga acagaccaga ctgcccaatg gaatacaataagagtcatat
32521 atgtaactca cattttacat taaaaagata aaaagaaaca agtgaaatttatcttaatat
32581 attttattta atccaatcta tccaatgtac tatcatttca acatgcaatcaatataaaaa
32641 atttatgagc tagcctacat tctttgtgct aagtctttga aatccagtgtgtgttgtaca
32701 cttacagcac atctcaattt agactctcta tttcatgccc aatagtcacatatggcccat
32761 agctaccttg ttggacagcc cagctcaaga gcatcaactc attagttcaggttttaccct
32821 atagaaccat gtaaaacaaa tctaattctt tctccatgtg actcatgttctaaaagtgtt
32881 agaaaatttt tgtggggttg gccgggaatg gtggctcatg cctgtaatcctagcactttg
32941 ggaggccgag atgggaggat cacttgaggt tgggagtttg aaaaccagccgggccggccg
33001 ggcgcggtgg ctcacgcctg tagtcccagc actttgggag gccgaggcgggcggatcacg
33061 aggtcaggag attgagacca tcctggctaa aacggtgaaa ccccgtctctactaaaaata
33121 caaaaaaaaa attagccggg cgtagtggcg ggcgcctgta gtcccagctacttgggaggc
33181 tgaggcagga gaatggcgtg aacccgggag gcggagcttg cagtgagccgagatcccgcc
33241 actgcactcc agcctgggca acagagcgag actccgtctc aaaaaaagaaaaaaaaaaaa
33301 aagaaaacca gccgggccaa catggcgaaa tcccatctct actactactaaaaaaaaaaa
33361 aaaaaaaaaa aaaaaaaaaa aaaaaatagc tgggcatggt gatgtgcgcctgtagtccca
33421 gctactcagg aggctgaggc atgagaatct cttgaacctg ggaggcagaggttgcagtga
33481 gccgaggtca tgccaccgca ctcgggcctg gatgacagag tgagactctgcctccaaaaa
33541 aagaaagaaa gaaagaaaga gagaaagaga aaaagaaaag aaaagaaagagagagagaga
33601 gaaagaaaga aagaaaagaa aagaaagaga gagaaagaaa gaaagaaaagaaagaaaaag
33661 aaaggaagga aggaaggata gaaagaaaga aagagaaaga aagtaagttactgtgggaag
33721 ggcaatatac ttagagctta aaggctctag ctgaggattt cctggcacaaagcctctgag
33781 acagttttgt acggaggagg tttgtaggca ggcacaaggc attaaagggtaaagagagag
33841 gcagcagacc acagcgcagt tgctaagagg catcagccta agccaatgggaagttgaagc
33901 tgggaacccc tgcgggggta agtcttaaat ctaggtgaag aggctgagccctgtagaccg
33961 ttcattggct gccttggaga ggggatgtag ccttaggaga ggcagcttatttctgctgga
34021 gataattctt gggaaggcac tcagccagta cacgtgtgta gagggtggtaagaagaatag
34081 ggaagaagag aagtgctgtt ctaagcagcg ggtatatgag cactcagggctggaggtgag
34141 agaacatact ggaagaagtt cagcatggtg gggatataat gggtggggacataatgggga
34201 aggggctggt tagatgtgag agaagaagct ggacaggctc acaggggcaaagcagaagga
34261 ccttgtaatt cttgcatggg agcttggatg tgatactaag gacaaagggaaaccacacaa
34321 ctggctaaag caggagagtg acagtaccca ttagaatttt aacaaaatcatatcagcaac
34381 agtgtagaag aggatgtgtt gactcggggc agggaaggag gcaggaaaccttttgggaag
34441 ttgtagcaat gatgtaagtg agaggcgcag ggtggactgg atcacaattgtttctcattc
34501 tcatctccta taagtcccca atgtggatca agttcacatt catttctccagtggccccat
34561 caaattgatg ggatttactg agcttactgc tcactatact ttttttccgcacatgtgact
34621 gttaagccaa ctgccttttc tacagtgact tctcttgccc agatgagcacatttaggtta
34681 gtgaatccaa gtctaattta attgagtctt gttagagtca ggtcattgctctaaattgtt
34741 aaaacaaacg atatacacaa acacacacac acacaaaaga ataaattgaggaggtcccaa
34801 ttctgtattt taaaatactt aatatatccc ttccttcttg aagagagctacaatttcaag
34861 aatttatttt gaaaaaattc tatcagttta ttgataaaaa tggtaaaaggaacaaagctg
34921 agaacagaac atatcatcag actctctagg gacggaaatc aatacataatacttcaagat
34981 atcaccctca gctacttgct gttccaccac cagttctctt gcatccagtttttgtttctt
35041 ttaacttggc tataaggatg tgagcacaga ctctgccaaa cagcctgctgaagttctgca
35101 aacaccttgt ggattgtgtt tccctgaaca accctgtcca acaatggccttgggcctgtc
35161 tgaagtattc ttagtgaact tctgctgcca cctagtgatc attgcgaatttttaaaaagc
35221 ctctttatcc tttaacaagt tactcttgtc ttaccccaaa gcggcatctgcctcactggc
35281 atatgactta cagagctcac attttccctc tccacaaagt tcaaaatggagacttctcag
35341 atttagcctt ccagcaccca ttctcaaacg tcgtgcatta cagaaaagtttaaactataa
35401 agttgaaccg cacgagattc tcattttgat atgtcattaa agtcagatattggcaagaac
35461 atatggttta acccaatggc ttggaatgct ggatgggatt cccagaagctccatacatcg
35521 gcctgcttca ggaccctttt attacaccaa ataaacccaa caaacatccatcgagtgcct
35581 attttatatc agaacaatga gacctgctcc ttctccttca ggacattttacttaatgggg
35641 gaaacataca agtaaacaga caaatgtaat cagtgcaaga aagaatcggacagcaatatg
35701 cacaggataa ggacacttag ctaaacctgc agacattggg aaagatgtcagggaaaaggg
35761 atggcagaag gaaagacaag gccaaaggca tgggactggg aggcactggaatatcagggc
35821 aacagaaagt gctgtcattt ggtataaatg gaacacacag gatatatgaaagcaagaaac
35881 agaagatgag tctgtgaggt tactatgatc cagttcatgg agggccttgtatgtcctggt
35941 gggaaaattg gtttttattg tgggaaggga accttttaat gcattcaaagcagtggaatg
36001 aagtgatttg gtttgcattt gttaatcatg tgaagaagaa taggttggagggataaaact
36061 tgtggtggtg agatgagtga cagagcgaca gccatctaca aaagaaacacaaggtacaga
36121 ctgaattgtg ggagtggtag tggggatgga aaataaagaa caaatttagagaggcagaac
36181 tgagtggaca tgatgctcag acttaccaga gcaggtgagt caagaatgatgtcaccattc
36241 cctaaatgag gcaaactggg agagaagcag atttggggag aaaactactaaacatgtacg
36301 tccctccaaa accttcaaga atgctaaagg gacagagtca agttcttccaaagtttctgt
36361 ctcttccatt tattttgcaa tgaatttcaa cttgttaatc agaaatggatttggagtagt
36421 agctattcaa ttgttttata caccttctag aagaaatatt tgtcagatgagtatgtcaaa
36481 aacttctcag accctcccct ttacttgaat gtatcttcca gcagatgttggtggaatcaa
36541 agttcattat tactcctata tcttttatac tagtgttatg atctgcagtgaggacatgca
36601 ttgctattgc tacgcctggc ctggaatgtc tgaggtgtat ttctacaacaccaattattt
36661 tgtgtgtctc tccttttaat ctccaccaaa aaatggagac agctagattcataaccctta
36721 gacatcctat attttattac taatacttgg ttgtggaagt ttgcattctaaacaagtcat
36781 caacataaaa atctctaaaa atattttatg aaaaatattc agcttatgatattttaaaaa
36841 tcacaaacct aagaaaacac acaaacctgt gtttgtattg tgaaatcagaggttaatctt
36901 cctcaccctg tgaaaaaatt aggggcataa atctatagga aggagattgggtgaatccaa
36961 gttacttacg gatgacataa aagatacaat caactttggt gatccaattgccacactaca
37021 actatctgac caacacgttt ctgtttctct ttagaccact ctcatctccaggaaccagct
37081 ctctgtgggc cacacatgat gtttgacgaa gatcgttgcg agtgtgtctgtaaaacacca
37141 tgtcccaaag atctaatcca gcaccccaaa aactgcagtt gctttgagtgcaaagaaagt
37201 ctggagacct gctgccagaa gcacaagcta tttcacccag acacctgcaggtaaatgcct
37261 tgagttgtct tgcctttact catgacattt aacgtagatg ccattttaatttggtgggat
37321 tccttagtaa gctaattttt ccccttggtg cctgagtccc ttttggataatagaacagag
37381 gtttagcagc taaggaataa gcaagagtat accgagtcat gattaatcatgaaaataaga
37441 aaatcaatcc tgcctgttat tatgtgtgta gagctttttt tttttagacggagtctcgct
37501 ctgtctccag gctggagtgc agtggcgtga tctgggctca ctgcaacctccgtctctctg
37561 gttcaaggga gtctcctgcc tcagcctccc aagtagctgg gattacaggcacgtgccacc
37621 acacccagct aatttttgta tttcagtaga gacggggttt caccatgttggccaggatag
37681 tcttgatctc ctgacctcat gatccacccg tctcggcctc ccaaagtgctgggattacag
37741 gcatgagcca ccgcgcccac ccggggttta gagctcttaa acaacaatgaaattggtaaa
37801 atttaagcag ttattaggat attgcttaat aataatattt taggaaggggaggtttcaga
37861 tcatcaacct gtttagttca atctctcatt gtttatgtct atatatgtttgtttttttct
37921 ttaatggagg gaatatcatt ggatttatat agcaagtaat ttattcatgaatagaacact
37981 tggaggttac tgattcactt cagtagattt tgaatccatg tgggataaccatgcaggatt
38041ttatactgac attttaaata catgtctgga aaacttaatc aaatcagagcagagttattc
38101 ttttgaatcc agtcattgat tctgaattct catctttatt ttcttttgcaacagctgtga
38161 ggacagatgc ccctttcata ccagaccatg tgcaagtggc aaaacagcatgtgcaaagca
38221 ttgccgcttt ccaaaggaga aaagggctgc ccaggggccc cacagccgaaagaatccttg
38281 attcagcgtt ccaagttccc catccctgtc atttttaaca gcatgctgctttgccaagtt
38341 gctgtcactg tttttttccc aggtgttaaa aaaaaaatcc attttacacagcaccacagt
38401 gaatccagac caaccttcca ttcacaccag ctaaggagtc cctggttcattgatggatgt
38461 cttctagctg cagatgcctc tgcgcaccaa ggaatggaga ggaggggacccatgtaatcc
38521 ttttgtttag ttttgttttt gttttttggt gaatgagaaa ggtgtgctggtcatggaatg
38581 gcaggtgtca tatgactgat tactcagagc agatgaggaa aactgtagtctctgagtcct
38641 ttgctaatcg caactcttgt gaattattct gattcttttt tatgcagaatttgattcgta
38701 tgatcagtac tgactttctg attactgtcc agcttatagt cttccagtttaatgaactac
38761 catctgatgt ttcatattta agtgtattta aagaaaataa acaccattattcaagccata
38821 taa
在本文所述的任何载体的一些实施方案中，载体包含编码可以特异性结合VEGF的抗体或抗原结合抗体片段的序列。在一些实施方案中，抗体或抗原结合抗体片段可包括人IgG Fc结构域(例如，SEQ ID NO:113)。在一些实施方案中，编码抗体或抗原结合片段的序列还可包含编码分泌信号序列的序列(例如，SEQ ID NO:92)。在本文所述的任何载体的一些实施方案中，载体包含T2A肽酶的序列(例如，SEQ ID NO:99)。
在一些实施方案中，抗体可以是人源化抗体、嵌合抗体或多价抗体。在一些实施方案中，抗体或抗原结合抗体片段可以是scFv-Fc、VHH结构域、VNAR结构域、(scFv)2、微抗体或BiTE。在一些实施方案中，抗体或抗原结合抗体片段可以是DVD-Ig和双亲和重靶向抗体(dual-affinity re-targeting antibody)(DART)、三功能抗体(triomab)、具有共同LC的kih IgG、crossmab、正交Fab IgG、二合一IgG(2-in-1-IgG)、IgG-ScFv、scFv2-Fc、双-纳米抗体、串联抗体、DART-Fc、scFv-HAS-scFv、DNL-Fab3、DAF(二合一或四合一)、DutaMab、DT-IgG、杵臼结构共有LC(knobs-in-holes common LC)、杵臼结构组件(knobs-in-holesassembly)、电荷对抗体、Fab臂交换抗体、SEEDbody、三功能抗体、LUZ-Y、Fcab、kλ体、正交Fab、DVD-IgG、IgG(H)-scFv、scFv-(H)IgG、IgG(L)-scFv、scFv-(L)-IgG、IgG(L,H)-Fc、IgG(H)-V、V(H)-IgG、IgG(L)-V、V(L)-IgG、KIH IgG-scFab、2scFv-IgG、IgG-2scFv、scFv4-Ig、Zybody、DVI-IgG、纳米抗体、纳米抗体-HSA、双抗体(diabody)、TandAb、scDiabody、scDiabody-CH3、双抗体-CH3、三联体(Triple Body)、微型抗体(miniantibody)、微抗体(minibody)、TriBi微抗体、scFv-CH3 KIH、Fab-scFv、scFv-CH-CL-scFv、F(ab')2-scFV2、scFv-KIH、Fab-scFv-Fc、四价HCAb、scDiabody-Fc、双抗体-Fc、串联scFv-Fc、细胞内抗体、对接和锁定(dock and lock)双特异性抗体、ImmTAC、HSAbody、scDiabody-HAS、串联scFv、IgG-IgG、Cov-X-Body和scFv1-PEG-scFv2。
抗体或抗原结合抗体片段的其它实例包括Fv片段、Fab片段、F(ab')2片段和Fab'片段。抗体或抗原结合抗体片段的其它实例包括：IgG的抗原结合片段(例如，IgG1、IgG2、IgG3或IgG4的抗原结合片段)(例如，人或人源化IgG(例如，人或人源化IgG1、IgG2、IgG3或IgG4)的抗原结合片段)；IgA的抗原结合片段(例如，IgA1或IgA2的抗原结合片段)(例如，人或人源化IgA(例如，人或人源化IgA1或IgA2)的抗原结合片段)；IgD的抗原结合片段(例如，人或人源化IgD的抗原结合片段)；IgE的抗原结合片段(例如，人或人源化IgE的抗原结合片段)；或IgM的抗原结合片段(例如，人或人源化IgM的抗原结合片段)。
本文所述的任何抗体或抗原结合抗体片段可与VEGF特异性结合。
VHH结构域是可在骆驼中发现的单一单体可变抗体结构域。VNAR结构域是可在软骨鱼中发现的单一单体可变抗体结构域。VHH结构域和VNAR结构域的非限制性方面描述于例如，Cromie等人，Curr.Top.Med.Chem.15:2543-2557,2016；De Genst等人，Dev.Comp.Immunol.30:187-198,2006；De Meyer等人，Trends Biotechnol.32:263-270,2014；Kijanka等人，Nanomedicine 10:161-174,2015；Kovaleva等人，Expert.Opin.Biol.Ther.14:1527-1539,2014；Krah等人，Immunopharmacol.Immunotoxicol.38:21-28,2016；Mujic-Delic等人，Trends Pharmacol.Sci.35:247-255,2014；Muyldermans,J.Biotechnol.74:277-302,2001；Muyldermans等人，TrendsBiochem.Sci.26:230-235,2001；Muyldermans,Ann.Rev.Biochem.82:775-797,2013；Rahbarizadeh等人，Immunol.Invest.40:299-338,2011；Van Audenhove等人，EBioMedicine 8:40-48,2016；Van Bockstaele等人，Curr.Opin.Investig.Drugs 10:1212-1224,2009；Vincke等人，Methods Mol.Biol.911:15-26,2012；以及Wesolowski等人，Med.Microbiol.Immunol.198:157-174,2009。
“Fv”片段包括一个重链可变结构域和一个轻链可变结构域的非共价连接的二聚体。
除了Fv片段的重链可变结构域和轻链可变结构域之外，“Fab”片段还包括轻链的恒定结构域和重链的第一恒定结构域(CH1)。
“F(ab')2”片段包括在铰链区附近通过二硫键连接的两个Fab片段。
“双重可变结构域免疫球蛋白”或“DVD-Ig”是指多价和多特异性结合蛋白，如例如，DiGiammarino等人，Methods Mol.Biol.899:145-156,2012；Jakob等人，MABs 5:358-363,2013；以及美国专利第7,612,181号、第8,258,268号、第8,586,714号、第8,716,450号、第8,722,855号、第8,735,546号和第8,822,645号中所描述的，所述参考文献各自通过引用以其整体并入。
DART描述于例如Garber,Nature Reviews Drug Discovery 13:799-801,2014中。
抗体和抗原结合抗体片段的其它方面在本领域中是已知的。
在一些实施方案中，本文所述的任何抗体或抗原结合抗体片段具有的解离常数(KD)小于1x10-5M(例如，小于0.5x10-5M、小于1x10-6M、小于0.5x10-6M、小于1x10-7M、小于0.5x10-7M、小于1x10-8M、小于0.5x10-8M、小于1x10-9M、小于0.5x10-9M、小于1x10-10M、小于0.5x10-10M、小于1x10-11M、小于0.5x10-11M或小于1x10-12M)，例如，如在磷酸盐缓冲盐水中使用表面等离子体共振(SPR)针对VEGF蛋白(例如，本文所述的任何VEGF蛋白，例如，成熟人VEGF-A、成熟人VEGF-B、成熟人VEGF-C和成熟人VEGF-D中的一种或多种)所测量的。
在一些实施方案中，本文所述的任何抗体或抗原结合抗体片段具有的KD为约1x10-12M至约1x10-5M、约0.5x10-5M、约1x10-6M、约0.5x10-6M、约1x10-7M、约0.5x10-7M、约1x10-8M、约0.5x10-8M、约1x10-9M、约0.5x10-9M、约1x10-10M、约0.5x10-10M、约1x10-11M或约0.5x10-11M(包括端值)；约0.5x10-11M至约1x10-5M、约0.5x10-5M、约1x10-6M、约0.5x10-6M、约1x10-7M、约0.5x10-7M、约1x10-8M、约0.5x10-8M、约1x10-9M、约0.5x10-9M、约1x10-10M、约0.5x10-10M或约1x10-11M(包括端值)；约1x10-11M至约1x10-5M、约0.5x10-5M、约1x10-6M、约0.5x10-6M、约1x10-7M、约0.5x10-7M、约1x10-8M、约0.5x10-8M、约1x10-9M、约0.5x10-9M、约1x10-10M或约0.5x10-10M(包括端值)；约0.5x10-10M至约1x10-5M、约0.5x10-5M、约1x10-6M、约0.5x10-6M、约1x10-7M、约0.5x10-7M、约1x10-8M、约0.5x10-8M、约1x10-9M、约0.5x10-9M或约1x10-10M(包括端值)；约1x10-10M至约1x10-5M、约0.5x10-5M、约1x10-6M、约0.5x10-6M、约1x10-7M、约0.5x10-7M、约1x10-8M、约0.5x10-8M、约1x10-9M或约0.5x10-9M(包括端值)；约0.5x10-9M至约1x10-5M、约0.5x10-5M、约1x10-6M、约0.5x10-6M、约1x10-7M、约0.5x10-7M、约1x10-8M、约0.5x10-8M或约1x10-9M(包括端值)；约1x10-9M至约1x10-5M、约0.5x10-5M、约1x10-6M、约0.5x10-6M、约1x10-7M、约0.5x10-7M、约1x10-8M或约0.5x10-8M(包括端值)；约0.5x10-8M至约1x10-5M、约0.5x10-5M、约1x10-6M、约0.5x10-6M、约1x10-7M、约0.5x10-7M或约1x10-8M(包括端值)；约1x10-8M至约1x10-5M、约0.5x10-5M、约1x10-6M、约0.5x10-6M、约1x10-7M或约0.5x10-7M(包括端值)；约0.5x10-7M至约1x10-5M、约0.5x10-5M、约1x10-6M、约0.5x10-6M或约1x10-7M(包括端值)；约1x10-7M至约1x10-5M、约0.5x10-5M、约1x10-6M或约0.5x10-6M(包括端值)；约0.5x10-6M至约1x10-5M、约0.5x10-5M或约1x10-6M(包括端值)；约1x10-6M至约1x10-5M或约0.5x10-5M(包括端值)；或约0.5x10-5M至约1x10-5M(包括端值)，例如，如在磷酸盐缓冲盐水中使用表面等离子体共振(SPR)针对VEGF蛋白(例如，本文所述的任何VEGF蛋白，例如，成熟人VEGF-A、成熟人VEGF-B、成熟人VEGF-C和成熟人VEGF-D中的一个或多个)所测量的。
可使用本领域已知的多种不同方法(例如，电泳迁移率变动测定、滤膜结合测定、表面等离子体共振和生物分子结合动力学测定等)来测定本文所述的任何抗体或抗原结合抗体片段的KD值。
在本文所述的任何抗体和/或抗原结合抗体片段的一些实施方案中，与类似受试者中的对照抗体和/或对照抗原结合抗体片段(例如，本文所述的任何对照抗体和/或对照抗原结合抗体片段)的半衰期相比，受试者(例如，人)中的抗体和/或抗原结合抗体片段的半衰期缩短约0.5倍至约4倍(例如，约0.5倍至约3.5倍、约0.5倍至约3倍、约0.5倍至约2.5倍、约0.5倍至约2倍、约0.5倍至约1.5倍、约0.5倍至约1倍、约1倍至约4倍、约1倍至约3.5倍、约1倍至约3倍、约1倍至约2.5倍、约1倍至约2倍、约1.5倍至约4倍、约1.5倍至约3.5倍、约1.5倍至约3倍、约1.5倍至约2.5倍、约1.5倍至约2倍、约2倍至约4倍、约2倍至约3.5倍、约2倍至约3倍、约2倍至约2.5倍、约2.5倍至约4倍、约2.5倍至约3.5倍、约2.5倍至约3倍、约3倍至约4倍、约3倍至约3.5倍或约3.5倍至约4倍)。参见，例如，Leabman等人，MAbs.5(6):896-903,2013。在一些实施方案中，本文所述的抗体或抗原结合抗体片段在Fc区中具有缩短其在哺乳动物中的半衰期的一个或多个氨基酸取代，并且对照抗体缺乏Fc区中的这些一个或多个氨基酸取代中的至少一个(例如，缺乏全部)。
在本文所述的任何抗体及其抗原结合片段的一些实例中，抗体和抗原结合片段可结合到VEGF抗原(例如，本文所述的任何示例性VEGF蛋白，例如，成熟人VEGF-A、成熟人VEGF-B、成熟人VEGF-C和成熟人VEGF-D中的一种或多种)(例如，本文所述的任何结合亲和力)。
在本文所述的一些实施方案中，抗体或抗原结合抗体片段可降低VEGF(例如，本文所述的任何示例性VEGF蛋白中的一种或多种，例如，成熟人VEGF-A、成熟人VEGF-B、成熟人VEGF-C和成熟人VEGF-D中的一种或多种)的活性。在一些实施方案中，抗体或抗原结合抗体片段可阻断VEGF(例如，本文所述的任何示例性VEGF蛋白中的一种或多种，例如，成熟人VEGF-A、成熟人VEGF-B、成熟人VEGF-C和成熟人VEGF-D中的一种或多种)与其受体中的一种或多种(例如，一种或多种VEGF受体)的结合。参见，例如，WO 1998/045331、US 9,079,953、US 2015/0147317、US 2016/0289314、Plotkin等人，Otology&Neurotology 33:1046-1052(2012)；和Ferrara等人，(2005)Biochem Biophys Res Commun 333(2):328-335。在一些实施方案中，抗体或抗原结合抗体可减弱下游信号传导(例如，VEGF受体(例如，本文所述的任何示例性VEGF受体中的一种或多种，例如，人VEGFR-1(SEQ ID NO:111)、人VEGFR-2(SEQ IDNO:112)和人VEGFR-3中的一种或多种)的下游信号传导)。在一些实施方案中，可以，例如通过分别与施用本文所述的任何AAV载体之前的哺乳动物的听力水平或听神经瘤、前庭神经鞘瘤或II型神经纤维瘤病的大小相比，哺乳动物的听力增强(例如，1％至约400％(或本文所述的该范围的任何子范围)的听力增强)、听神经瘤、前庭神经鞘瘤或II型神经纤维瘤病的一个或多个症状的大小或严重程度的降低(例如，1％至99％、1％至95％、1％至90％、1％至85％、1％至80％、1％至75％、1％至70％、1％至65％、1％至60％、1％至55％、1％至50％、1％至45％、1％至40％、1％至35％、1％至30％、1％至25％、1％至20％、1％至15％、1％至10％、1％至5％、5％至99％、5％至95％、5％至90％、5％至85％、5％至80％、5％至75％、5％至70％、5％至65％、5％至60％、5％至55％、5％至50％、5％至45％、5％至40％、5％至35％、5％至30％、5％至25％、5％至20％、5％至15％、5％至10％、10％至99％、10％至95％、10％至90％、10％至85％、10％至80％、10％至75％、10％至70％、10％至65％、10％至60％、10％至55％、10％至50％、10％至45％、10％至40％、10％至35％、10％至30％、10％至25％、10％至20％、10％至15％、15％至99％、15％至95％、15％至90％、15％至85％、15％至80％、15％至75％、15％至70％、15％至65％、15％至60％、15％至55％、15％至50％、15％至45％、15％至40％、15％至35％、15％至30％、15％至25％、15％至20％、20％至99％、20％至95％、20％至90％、20％至85％、20％至80％、20％至75％、20％至70％、20％至65％、20％至60％、20％至55％、20％至50％、20％至45％、20％至40％、20％至35％、20％至30％、20％至25％、25％至99％、25％至95％、25％至90％、25％至85％、25％至80％、25％至75％、25％至70％、25％至65％、25％至60％、25％至55％、25％至50％、25％至45％、25％至40％、25％至35％、25％至30％、30％至99％、30％至95％、30％至90％、30％至85％、30％至80％、30％至75％、30％至70％、30％至65％、30％至60％、30％至55％、30％至50％、30％至45％、30％至40％、30％至35％、35％至99％、35％至95％、35％至90％、35％至85％、35％至80％、35％至75％、35％至70％、35％至65％、35％至60％、35％至55％、35％至50％、35％至45％、35％至40％、40％至99％、40％至95％、40％至90％、40％至85％、40％至80％、40％至75％、40％至70％、40％至65％、40％至60％、40％至55％、40％至50％、40％至45％、45％至99％、45％至95％、45％至90％、45％至85％、45％至80％、45％至75％、45％至70％、45％至65％、45％至60％、45％至55％、45％至50％、50％至99％、50％至95％、50％至90％、50％至85％、50％至80％、50％至75％、50％至70％、50％至65％、50％至60％、50％至55％、55％至99％、55％至95％、55％至90％、55％至85％、55％至80％、55％至75％、55％至70％、55％至65％、55％至60％、60％至99％、60％至95％、60％至90％、60％至85％、60％至80％、60％至75％、60％至70％、60％至65％、65％至99％、65％至95％、65％至90％、65％至85％、65％至80％、65％至75％、65％至70％、70％至99％、70％至95％、70％至90％、70％至85％、70％至80％、70％至75％、75％至99％、75％至95％、75％至90％、75％至85％、75％至80％、80％至99％、80％至95％、80％至90％、80％至85％、85％至99％、85％至95％、85％至90％、90％至99％、90％至95％或95％至99％的降低)间接地检测到VEGF活性的降低。在一些实施方案中，可在体外测定中检测到VEGF活性的降低。
在一些实施方案中，与VEGF特异性结合的抗体是贝伐单抗
Figure BDA0003112389540005051
(SEQ IDNO:103)或其抗原结合片段。贝伐单抗(全长抗体约150kDa)抑制VEGF-A的所有异型体。贝伐单抗于2004年获得食品和药物管理局(FDA)批准用于结肠癌，静脉内(IV)剂量为4.0-7.5mg/kg，2-3周(血浆半衰期为21天)，玻璃体内(IVT)剂量为1.25mg/0.05mL(半衰期为5.6天)。贝伐单抗对于VEGF 165(VEGF-A)的KD为58pM。参见，例如，WO 2017/050825。贝伐单抗的前导序列是SEQ ID NO:104，贝伐单抗的重链可变域是SEQ ID NO:105，贝伐单抗的重链恒定区是SEQ ID NO:106，贝伐单抗的轻链可变域是SEQ ID NO:107，贝伐单抗的轻链恒定区是SEQ ID NO:108。编码贝伐单抗的示例性cDNA序列是SEQ ID NO:109。
在一些实施方案中，与VEGF特异性结合的抗体是雷珠单抗
Figure BDA0003112389540005052
(SEQ IDNO:95)或其抗原结合片段。雷珠单抗(约50kDa)抑制VEGF-A的所有异型体。贝伐单抗于2006年获得FDA批准用于眼部用途，静脉内(IV)剂量为4.0-7.5mg/kg，2-3周(血浆半衰期为0.5天)，玻璃体内(IVT)剂量为0.5mg/0.05mL(半衰期为3.2天)。雷珠单抗对于VEGF 165(VEGF-A)的KD为46pM。参见，例如，WO 2014/178078。雷珠单抗的前导序列具有SEQ ID NO:96的序列，雷珠单抗的重链可变域具有SEQ ID NO:97的序列，雷珠单抗的重链恒定区具有SEQ IDNO:98的序列，雷珠单抗的轻链可变结构域具有SE QID NO:100的序列，雷珠单抗的轻链恒定区具有SEQ ID NO:101的序列。编码雷珠单抗的示例性cDNA序列是SEQ ID NO:102。
在一些实施方案中，特异性结合到VEGF的抗体是sevacizumab(APX003/SIM-BD0801)或其抗原结合片段。
在一些实施方案中，与VEGF特异性结合的抗体或其抗原结合片段是阿柏西普(SEQ ID NO:110)。编码阿柏西普的示例性cDNA序列是SEQ ID NO:114。
在本文所述的与VEGF特异性结合的抗体及其抗原结合片段的一些实施方案中，抗体或其抗原结合片段包含可变轻链结构域，所述可变轻链结构域为或包括与贝伐单抗的可变轻链结构域具有至少80％同一性(例如，至少82％、至少84％、至少86％、至少88％、至少90％、至少92％、至少94％、至少96％、至少98％或至少99％同一性)的序列；并且/或者包含可变重链结构域，所述可变重链结构域为或包括与贝伐单抗的可变重链结构域具有至少80％同一性(例如，至少82％、至少84％、至少86％、至少88％、至少90％、至少92％、至少94％、至少96％、至少98％或至少99％同一性)的序列。
在本文所述的与VEGF特异性结合的抗体及其抗原结合片段的一些实施方案中，抗体或其抗原结合片段包含可变轻链结构域，所述可变轻链结构域为或包括贝伐单抗的可变轻链结构域；和/或可变重链结构域，所述可变重链结构域为或包括贝伐单抗的可变重链结构域。在本文所述的与VEGF特异性结合的抗体及其抗原结合片段的一些实施方案中，抗体或其抗原结合片段包含可变轻链结构域，所述可变轻链结构域为或包括贝伐单抗的可变轻链结构域的序列，不同之处在于其包含一个、两个、三个、四个、五个、六个、七个、八个、九个、十个、十一个、十二个、十三个、十四个或十五个氨基酸取代；并且/或者包含可变重链结构域，所述可变重链结构域为或包括贝伐单抗的可变重链的序列，不同之处在于其包含一个、两个、三个、四个、五个、六个、七个、八个、九个、十个、十一个、十二个、十三个、十四个或十五个氨基酸取代。在一些实施方案中，第一抗原结合结构域包含贝伐单抗的轻链可变结构域中的三个CDR和/或贝伐单抗的重链可变结构域中的三个CDR。
在本文所述的与VEGF特异性结合的抗体及其抗原结合片段的一些实施方案中，抗体或其抗原结合片段包含可变轻链结构域，所述可变轻链结构域为或包括与雷珠单抗的可变轻链结构域具有至少80％同一性(例如，至少82％、至少84％、至少86％、至少88％、至少90％、至少92％、至少94％、至少96％、至少98％或至少99％同一性)的序列；并且/或者包含可变重链结构域，所述可变重链结构域为或包括与雷珠单抗的可变重链结构域具有至少80％同一性(例如，至少82％、至少84％、至少86％、至少88％、至少90％、至少92％、至少94％、至少96％、至少98％或至少99％同一性)的序列。
在本文所述的与VEGF特异性结合的抗体及其抗原结合片段的一些实施方案中，抗体或其抗原结合片段包含可变轻链结构域，所述可变轻链结构域为或包括雷珠单抗的可变轻链结构域；和/或可变重链结构域，所述可变重链结构域为或包括雷珠单抗的可变重链结构域。在本文所述的与VEGF特异性结合的抗体及其抗原结合片段的一些实施方案中，抗体或其抗原结合片段包括可变轻链结构域，所述可变轻链结构域为或包括雷珠单抗的可变轻链结构域的序列，不同之处在于其包含一个、两个、三个、四个、五个、六个、七个、八个、九个、十个、十一个、十二个、十三个、十四个或十五个氨基酸取代；并且/或者包含可变重链结构域，所述可变重链结构域为或包含雷珠单抗的可变重链的序列，不同之处在于其包含一个、两个、三个、四个、五个、六个、七个、八个、九个、十个、十一个、十二个、十三个、十四个或十五个氨基酸取代。在一些实施方案中，第一抗原结合结构域包括雷珠单抗的轻链可变结构域中的三个CDR和/或雷珠单抗的重链可变结构域中的三个CDR。
载体
本文提供的组合物包含至少两种(例如，两种、三种、四种、五种或六种)核酸载体，其中：所述至少两种不同的载体中的每一种包含编码靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)的不同部分的编码序列，所述编码的部分中的每一部分至少为30个氨基酸(例如，约30个氨基酸至约800个氨基酸、约30个氨基酸至约750个氨基酸、约30个氨基酸至约700个氨基酸、约30个氨基酸至约650个氨基酸、约30个氨基酸至约600个氨基酸、约30个氨基酸至约550个氨基酸、约30个氨基酸至约500个氨基酸、约30个氨基酸至约450个氨基酸、约30个氨基酸至约400个氨基酸、约30个氨基酸至约350个氨基酸、约30个氨基酸至约300个氨基酸、约30个氨基酸至约250个氨基酸、约30个氨基酸至约200个氨基酸、约30个氨基酸至约150个氨基酸、约30个氨基酸至约100个氨基酸、约30个氨基酸至约50个氨基酸、约50个氨基酸至约800个氨基酸、约50个氨基酸至约750个氨基酸、约50个氨基酸至约700个氨基酸、约50个氨基酸至约650个氨基酸、约50个氨基酸至约600个氨基酸、约50个氨基酸至约550个氨基酸、约50个氨基酸至约500个氨基酸、约50个氨基酸至约450个氨基酸、约50个氨基酸至约400个氨基酸、约50个氨基酸至约350个氨基酸、约50个氨基酸至约300个氨基酸、约50个氨基酸至约250个氨基酸、约50个氨基酸至约200个氨基酸、约50个氨基酸至约150个氨基酸、约50个氨基酸至约100个氨基酸、约100个氨基酸至约1600个氨基酸、约100个氨基酸至约800个氨基酸、约100个氨基酸至约750个氨基酸、约100个氨基酸至约700个氨基酸、约100个氨基酸至约650个氨基酸、约100个氨基酸至约600个氨基酸、约100个氨基酸至约550个氨基酸、约100个氨基酸至约500个氨基酸、约100个氨基酸至约450个氨基酸、约100个氨基酸至约400个氨基酸、约100个氨基酸至约350个氨基酸、约100个氨基酸至约300个氨基酸、约100个氨基酸至约250个氨基酸、约100个氨基酸至约200个氨基酸、约100个氨基酸至约150个氨基酸、约150个氨基酸至约800个氨基酸、约150个氨基酸至约750个氨基酸、约150个氨基酸至约700个氨基酸、约150个氨基酸至约650个氨基酸、约150个氨基酸至约600个氨基酸、约150个氨基酸至约550个氨基酸、约150个氨基酸至约500个氨基酸、约150个氨基酸至约450个氨基酸、约150个氨基酸至约400个氨基酸、约150个氨基酸至约350个氨基酸、约150个氨基酸至约300个氨基酸、约150个氨基酸至约250个氨基酸、约150个氨基酸至约200个氨基酸、约200个氨基酸至约800个氨基酸、约200个氨基酸至约750个氨基酸、约200个氨基酸至约700个氨基酸、约200个氨基酸至约650个氨基酸、约200个氨基酸至约600个氨基酸、约200个氨基酸至约550个氨基酸、约200个氨基酸至约500个氨基酸、约200个氨基酸至约450个氨基酸、约200个氨基酸至约400个氨基酸、约200个氨基酸至约350个氨基酸、约200个氨基酸至约300个氨基酸、约200个氨基酸至约250个氨基酸、约250个氨基酸至约800个氨基酸、约250个氨基酸至约750个氨基酸、约250个氨基酸至约700个氨基酸、约250个氨基酸至约650个氨基酸、约250个氨基酸至约600个氨基酸、约250个氨基酸至约550个氨基酸、约250个氨基酸至约500个氨基酸、约250个氨基酸至约450个氨基酸、约250个氨基酸至约400个氨基酸、约250个氨基酸至约350个氨基酸、约250个氨基酸至约300个氨基酸、约300个氨基酸至约800个氨基酸、约300个氨基酸至约750个氨基酸、约300个氨基酸至约700个氨基酸、约300个氨基酸至约650个氨基酸、约300个氨基酸至约600个氨基酸、约300个氨基酸至约550个氨基酸、约300个氨基酸至约500个氨基酸、约300个氨基酸至约450个氨基酸、约300个氨基酸至约400个氨基酸、约300个氨基酸至约350个氨基酸、约350个氨基酸至约800个氨基酸、约350个氨基酸至约750个氨基酸、约350个氨基酸至约700个氨基酸、约350个氨基酸至约650个氨基酸、约350个氨基酸至约600个氨基酸、约350个氨基酸至约550个氨基酸、约350个氨基酸至约500个氨基酸、约350个氨基酸至约450个氨基酸、约350个氨基酸至约400个氨基酸、约400个氨基酸至约800个氨基酸、约400个氨基酸至约750个氨基酸、约400个氨基酸至约700个氨基酸、约400个氨基酸至约650个氨基酸、约400个氨基酸至约600个氨基酸、约400个氨基酸至约550个氨基酸、约400个氨基酸至约500个氨基酸、约400个氨基酸至约450个氨基酸、约450个氨基酸至约800个氨基酸、约450个氨基酸至约750个氨基酸、约450个氨基酸至约700个氨基酸、约450个氨基酸至约650个氨基酸、约450个氨基酸至约600个氨基酸、约450个氨基酸至约550个氨基酸、约450个氨基酸至约500个氨基酸、约500个氨基酸至约800个氨基酸、约500个氨基酸至约750个氨基酸、约500个氨基酸至约700个氨基酸、约500个氨基酸至约650个氨基酸、约500个氨基酸至约600个氨基酸、约500个氨基酸至约550个氨基酸、约550个氨基酸至约800个氨基酸、约550个氨基酸至约750个氨基酸、约550个氨基酸至约700个氨基酸、约550个氨基酸至约650个氨基酸、约550个氨基酸至约600个氨基酸、约600个氨基酸至约800个氨基酸、约600个氨基酸至约750个氨基酸、约600个氨基酸至约700个氨基酸、约600个氨基酸至约650个氨基酸、约650个氨基酸至约800个氨基酸、约650个氨基酸至约750个氨基酸、约650个氨基酸至约700个氨基酸、约700个氨基酸至约800个氨基酸、约700个氨基酸至约750个氨基酸或约750个氨基酸至约800个氨基酸)，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；所述至少两种不同的载体中单一载体均不编码活性靶蛋白(例如，活性支持细胞靶蛋白(例如，全长支持细胞靶蛋白(例如，全长野生型支持细胞靶蛋白))或活性毛细胞靶蛋白(例如，全长毛细胞靶蛋白(例如，全长野生型毛细胞靶蛋白)))；并且，当被引入到灵长类动物细胞时，所述至少两种不同的载体经历彼此同源重组，其中所述重组核酸编码活性靶蛋白(例如，活性支持细胞靶蛋白(例如，全长支持细胞靶蛋白)或活性毛细胞靶蛋白(例如，全长毛细胞靶蛋白))。在一些实施方案中，所述核酸载体之一可包含编码靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)的一部分的编码序列，其中所述编码的部分的长度为例如约30个氨基酸至约800个氨基酸、约30个氨基酸至约750个氨基酸、约30个氨基酸至约700个氨基酸、约30个氨基酸至约650个氨基酸、约30个氨基酸至约600个氨基酸、约30个氨基酸至约550个氨基酸、约30个氨基酸至约500个氨基酸、约30个氨基酸至约450个氨基酸、约30个氨基酸至约400个氨基酸、约30个氨基酸至约350个氨基酸、约30个氨基酸至约300个氨基酸、约30个氨基酸至约250个氨基酸、约30个氨基酸至约200个氨基酸、约30个氨基酸至约150个氨基酸、约30个氨基酸至约100个氨基酸、约30个氨基酸至约50个氨基酸、约50个氨基酸至约800个氨基酸、约50个氨基酸至约750个氨基酸、约50个氨基酸至约700个氨基酸、约50个氨基酸至约650个氨基酸、约50个氨基酸至约600个氨基酸、约50个氨基酸至约550个氨基酸、约50个氨基酸至约500个氨基酸、约50个氨基酸至约450个氨基酸、约50个氨基酸至约400个氨基酸、约50个氨基酸至约350个氨基酸、约50个氨基酸至约300个氨基酸、约50个氨基酸至约250个氨基酸、约50个氨基酸至约200个氨基酸、约50个氨基酸至约150个氨基酸、约50个氨基酸至约100个氨基酸、约100个氨基酸至约1600个氨基酸、约100个氨基酸至约800个氨基酸、约100个氨基酸至约750个氨基酸、约100个氨基酸至约700个氨基酸、约100个氨基酸至约650个氨基酸、约100个氨基酸至约600个氨基酸、约100个氨基酸至约550个氨基酸、约100个氨基酸至约500个氨基酸、约100个氨基酸至约450个氨基酸、约100个氨基酸至约400个氨基酸、约100个氨基酸至约350个氨基酸、约100个氨基酸至约300个氨基酸、约100个氨基酸至约250个氨基酸、约100个氨基酸至约200个氨基酸、约100个氨基酸至约150个氨基酸、约150个氨基酸至约800个氨基酸、约150个氨基酸至约750个氨基酸、约150个氨基酸至约700个氨基酸、约150个氨基酸至约650个氨基酸、约150个氨基酸至约600个氨基酸、约150个氨基酸至约550个氨基酸、约150个氨基酸至约500个氨基酸、约150个氨基酸至约450个氨基酸、约150个氨基酸至约400个氨基酸、约150个氨基酸至约350个氨基酸、约150个氨基酸至约300个氨基酸、约150个氨基酸至约250个氨基酸、约150个氨基酸至约200个氨基酸、约200个氨基酸至约800个氨基酸、约200个氨基酸至约750个氨基酸、约200个氨基酸至约700个氨基酸、约200个氨基酸至约650个氨基酸、约200个氨基酸至约600个氨基酸、约200个氨基酸至约550个氨基酸、约200个氨基酸至约500个氨基酸、约200个氨基酸至约450个氨基酸、约200个氨基酸至约400个氨基酸、约200个氨基酸至约350个氨基酸、约200个氨基酸至约300个氨基酸、约200个氨基酸至约250个氨基酸、约250个氨基酸至约800个氨基酸、约250个氨基酸至约750个氨基酸、约250个氨基酸至约700个氨基酸、约250个氨基酸至约650个氨基酸、约250个氨基酸至约600个氨基酸、约250个氨基酸至约550个氨基酸、约250个氨基酸至约500个氨基酸、约250个氨基酸至约450个氨基酸、约250个氨基酸至约400个氨基酸、约250个氨基酸至约350个氨基酸、约250个氨基酸至约300个氨基酸、约300个氨基酸至约800个氨基酸、约300个氨基酸至约750个氨基酸、约300个氨基酸至约700个氨基酸、约300个氨基酸至约650个氨基酸、约300个氨基酸至约600个氨基酸、约300个氨基酸至约550个氨基酸、约300个氨基酸至约500个氨基酸、约300个氨基酸至约450个氨基酸、约300个氨基酸至约400个氨基酸、约300个氨基酸至约350个氨基酸、约350个氨基酸至约800个氨基酸、约350个氨基酸至约750个氨基酸、约350个氨基酸至约700个氨基酸、约350个氨基酸至约650个氨基酸、约350个氨基酸至约600个氨基酸、约350个氨基酸至约550个氨基酸、约350个氨基酸至约500个氨基酸、约350个氨基酸至约450个氨基酸、约350个氨基酸至约400个氨基酸、约400个氨基酸至约800个氨基酸、约400个氨基酸至约750个氨基酸、约400个氨基酸至约700个氨基酸、约400个氨基酸至约650个氨基酸、约400个氨基酸至约600个氨基酸、约400个氨基酸至约550个氨基酸、约400个氨基酸至约500个氨基酸、约400个氨基酸至约450个氨基酸、约450个氨基酸至约800个氨基酸、约450个氨基酸至约750个氨基酸、约450个氨基酸至约700个氨基酸、约450个氨基酸至约650个氨基酸、约450个氨基酸至约600个氨基酸、约450个氨基酸至约550个氨基酸、约450个氨基酸至约500个氨基酸、约500个氨基酸至约800个氨基酸、约500个氨基酸至约750个氨基酸、约500个氨基酸至约700个氨基酸、约500个氨基酸至约650个氨基酸、约500个氨基酸至约600个氨基酸、约500个氨基酸至约550个氨基酸、约550个氨基酸至约800个氨基酸、约550个氨基酸至约750个氨基酸、约550个氨基酸至约700个氨基酸、约550个氨基酸至约650个氨基酸、约550个氨基酸至约600个氨基酸、约600个氨基酸至约800个氨基酸、约600个氨基酸至约750个氨基酸、约600个氨基酸至约700个氨基酸、约600个氨基酸至约650个氨基酸、约650个氨基酸至约800个氨基酸、约650个氨基酸至约750个氨基酸、约650个氨基酸至约700个氨基酸、约700个氨基酸至约800个氨基酸、约700个氨基酸至约750个氨基酸或约750个氨基酸至约800个氨基酸。
在这些组合物的一些实施方案中，编码序列中的至少一个包含跨越靶基因组DNA(例如，支持细胞靶基因组DNA或毛细胞靶基因组DNA)的两个相邻外显子的核苷酸序列，并且缺乏天然存在于两个相邻的外显子之间的内含子序列。
在一些实施方案中，所述编码的部分中没有一个部分的氨基酸序列与所述编码的部分中的不同的一个部分的氨基酸序列甚至部分地重叠。在一些实施方案中，所述编码的部分中的一个或多个部分的氨基酸序列与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠。在一些实施方案中，所述编码的部分中的每一个的氨基酸序列与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠。
在一些实施方案中，重叠的氨基酸序列的长度为约30个氨基酸残基至约800个氨基酸(例如，或本文所述的该范围的任何子范围)。
在一些实例中，所述载体包括两种不同的载体，其中的每一种包含内含子的不同区段，其中所述内含子包含存在于靶基因组DNA(例如，支持细胞靶基因组DNA(例如，SLC26A4基因组DNA或GJB2基因组DNA)(例如，本文所述的SEQ ID NO:3中的任何示例性内含子)或毛细胞靶基因组DNA(例如，OTOF基因组DNA、TRIOBP基因组DNA、PJVK基因组DNA、NDP基因组DNA、CLRN1基因组DNA、TMC1基因组DNA、VEGF基因组DNA、HSPA1A基因组DNA或STRC基因组DNA(例如，本文所述的SEQ ID NO:19、SEQ ID NO:22、SEQ ID NO:33、SEQ ID NO:37、SEQID NO:47、SEQ ID NO:50、SEQ ID NO:61、SEQ ID NO:71或SEQ ID NO:80中的任何示例性内含子)中的内含子的核苷酸序列，并且其中所述两个不同区段在序列上重叠的长度为至少100个核苷酸(例如，约100个核苷酸至约3,000个核苷酸、约100个核苷酸至约2,500个核苷酸、约100个核苷酸至约2,000个核苷酸、约100个核苷酸至约1,500个核苷酸、约100个核苷酸至约1,000个核苷酸、约100个核苷酸至约800个核苷酸、约100个核苷酸至约600个核苷酸、约100个核苷酸至约400个核苷酸、约100个核苷酸至约200个核苷酸、约200个核苷酸至约3,000个核苷酸、约200个核苷酸至约2,500个核苷酸、约200个核苷酸至约2,000个核苷酸、约200个核苷酸至约1,500个核苷酸、约200个核苷酸至约1,000个核苷酸、约200个核苷酸至约800个核苷酸、约200个核苷酸至约600个核苷酸、约200个核苷酸至约400个核苷酸、约400个核苷酸至约3,000个核苷酸、约400个核苷酸至约2,500个核苷酸、约400个核苷酸至约2,000个核苷酸、约400个核苷酸至约1,500个核苷酸、约400个核苷酸至约1,000个核苷酸、约400个核苷酸至约800个核苷酸、约400个核苷酸至约600个核苷酸、约600个核苷酸至约3,000个核苷酸、约600个核苷酸至约2,500个核苷酸、约600个核苷酸至约2,000个核苷酸、约600个核苷酸至约1,500个核苷酸、约600个核苷酸至约1,000个核苷酸、约600个核苷酸至约800个核苷酸、约800个核苷酸至约3,000个核苷酸、约800个核苷酸至约2,500个核苷酸、约800个核苷酸至约2,000个核苷酸、约800个核苷酸至约1,500个核苷酸、约800个核苷酸至约1,000个核苷酸、约1,000个核苷酸至约3,000个核苷酸、约1,000个核苷酸至约2,500个核苷酸、约1,000个核苷酸至约2,000个核苷酸、约1,000个核苷酸至约1,500个核苷酸、约1,500个核苷酸至约3,000个核苷酸、约1,500个核苷酸至约2,500个核苷酸、约1,500个核苷酸至约2,000个核苷酸、约2,000个核苷酸至约3,000个核苷酸、约2,000个核苷酸至约2,500个核苷酸或约2,500个核苷酸至约3,000个核苷酸)。
在任何两种不同的载体中的重叠核苷酸序列可包含靶基因(例如，支持细胞靶基因(例如，SLC26A4基因或GJB2基因)(例如，本文所述的SEQ ID NO:3中的示例性外显示中的任一个或多个)或毛细胞靶基因(例如，OTOF基因、TRIOBP基因、PJVK基因、NDP基因、CLRN1基因、TMC1基因或STRC基因)(例如，本文所述的SEQ ID NO:19、SEQ ID NO:22、SEQ ID NO:33、SEQ ID NO:37、SEQ ID NO:47、SEQ ID NO:50、SEQ ID NO:63、SEQ ID NO:71或SEQ ID NO:80中的示例性外显子中的任一个或多个))的一个或多个外显子的部分或全部。
在一些实施方案中，组合物中不同载体的数目为2、3、4或5。在其中组合物中不同载体的数目为2的组合物中，两种不同的载体中的第一载体可以包含编码靶蛋白的N末端部分(例如，支持细胞靶蛋白的N末端部分或毛细胞靶蛋白的N末端部分)的编码序列。在一些实例中，靶基因的N末端部分(例如，支持细胞靶基因的N末端部分或毛细胞靶基因的N末端部分)的长度为约30个氨基酸至约800个氨基酸(例如，约30个氨基酸至约790个氨基酸、约30个氨基酸至约780个氨基酸、约30个氨基酸至约770个氨基酸、约30个氨基酸至约760个氨基酸、约30个氨基酸至约750个氨基酸、约30个氨基酸至约740个氨基酸、约30个氨基酸至约730个氨基酸、约30个氨基酸至约720个氨基酸、约30个氨基酸至约710个氨基酸、约30个氨基酸至约700个氨基酸、约30个氨基酸至约690个氨基酸、约30个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约30个氨基酸至约660个氨基酸、约30个氨基酸至约650个氨基酸、约30个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约30个氨基酸至约620个氨基酸、约30个氨基酸至约610个氨基酸、约30个氨基酸至约600个氨基酸、约30个氨基酸至约590个氨基酸、约30个氨基酸至约580个氨基酸、约30个氨基酸至约570个氨基酸、约30个氨基酸至约560个氨基酸、约30个氨基酸至约550个氨基酸、约30个氨基酸至约540个氨基酸、约30个氨基酸至约530个氨基酸、约30个氨基酸至约520个氨基酸、约30个氨基酸至约510个氨基酸、约30个氨基酸至约500个氨基酸、约30个氨基酸至约490个氨基酸、约30个氨基酸至约480个氨基酸、约30个氨基酸至约470个氨基酸、约30个氨基酸至约460个氨基酸、约30个氨基酸至约450个氨基酸、约30个氨基酸至约440个氨基酸、约30个氨基酸至约430个氨基酸、约30个氨基酸至约420个氨基酸、约30个氨基酸至约410个氨基酸、约30个氨基酸至约400个氨基酸、约30个氨基酸至约390个氨基酸、约30个氨基酸至约380个氨基酸、约30个氨基酸至约370个氨基酸、约30个氨基酸至约360个氨基酸、约30个氨基酸至约350个氨基酸、约30个氨基酸至约340个氨基酸、约30个氨基酸至约330个氨基酸、约30个氨基酸至约320个氨基酸、约30个氨基酸至约310个氨基酸、约30个氨基酸至约300个氨基酸、约30个氨基酸至约290个氨基酸、约30个氨基酸至约280个氨基酸、约30个氨基酸至约270个氨基酸、约30个氨基酸至约260个氨基酸、约30个氨基酸至约250个氨基酸、约30个氨基酸至约240个氨基酸、约30个氨基酸至约230个氨基酸、约30个氨基酸至约220个氨基酸、约30个氨基酸至约210个氨基酸、约30个氨基酸至约200个氨基酸、约30个氨基酸至约190个氨基酸、约30个氨基酸至约180个氨基酸、约30个氨基酸至约170个氨基酸、约30个氨基酸至约160个氨基酸、约30个氨基酸至约150个氨基酸、约30个氨基酸至约140个氨基酸、约30个氨基酸至约130个氨基酸、约30个氨基酸至约120个氨基酸、约30个氨基酸至约110个氨基酸、约30个氨基酸至约100个氨基酸、约30个氨基酸至约90个氨基酸、约30个氨基酸至约80个氨基酸、约30个氨基酸至约70个氨基酸、约30个氨基酸至约60个氨基酸、约30个氨基酸至约50个氨基酸、约30个氨基酸至约40个氨基酸、约50个氨基酸至约800个氨基酸、约50个氨基酸至约790个氨基酸、约50个氨基酸至约780个氨基酸、约50个氨基酸至约770个氨基酸、约50个氨基酸至约760个氨基酸、约50个氨基酸至约750个氨基酸、约50个氨基酸至约740个氨基酸、约50个氨基酸至约730个氨基酸、约50个氨基酸至约720个氨基酸、约50个氨基酸至约710个氨基酸、约50个氨基酸至约700个氨基酸、约50个氨基酸至约690个氨基酸、约50个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约50个氨基酸至约660个氨基酸、约50个氨基酸至约650个氨基酸、约50个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约50个氨基酸至约620个氨基酸、约50个氨基酸至约610个氨基酸、约50个氨基酸至约600个氨基酸、约50个氨基酸至约590个氨基酸、约50个氨基酸至约580个氨基酸、约50个氨基酸至约570个氨基酸、约50个氨基酸至约560个氨基酸、约50个氨基酸至约550个氨基酸、约50个氨基酸至约540个氨基酸、约50个氨基酸至约530个氨基酸、约50个氨基酸至约520个氨基酸、约50个氨基酸至约510个氨基酸、约50个氨基酸至约500个氨基酸、约50个氨基酸至约490个氨基酸、约50个氨基酸至约480个氨基酸、约50个氨基酸至约470个氨基酸、约50个氨基酸至约460个氨基酸、约50个氨基酸至约450个氨基酸、约50个氨基酸至约440个氨基酸、约50个氨基酸至约430个氨基酸、约50个氨基酸至约420个氨基酸、约50个氨基酸至约410个氨基酸、约50个氨基酸至约400个氨基酸、约50个氨基酸至约390个氨基酸、约50个氨基酸至约380个氨基酸、约50个氨基酸至约370个氨基酸、约50个氨基酸至约360个氨基酸、约50个氨基酸至约350个氨基酸、约50个氨基酸至约340个氨基酸、约50个氨基酸至约330个氨基酸、约50个氨基酸至约320个氨基酸、约50个氨基酸至约310个氨基酸、约50个氨基酸至约300个氨基酸、约50个氨基酸至约290个氨基酸、约50个氨基酸至约280个氨基酸、约50个氨基酸至约270个氨基酸、约50个氨基酸至约260个氨基酸、约50个氨基酸至约250个氨基酸、约50个氨基酸至约240个氨基酸、约50个氨基酸至约230个氨基酸、约50个氨基酸至约220个氨基酸、约50个氨基酸至约210个氨基酸、约50个氨基酸至约200个氨基酸、约50个氨基酸至约190个氨基酸、约50个氨基酸至约180个氨基酸、约50个氨基酸至约170个氨基酸、约50个氨基酸至约160个氨基酸、约50个氨基酸至约150个氨基酸、约50个氨基酸至约140个氨基酸、约50个氨基酸至约130个氨基酸、约50个氨基酸至约120个氨基酸、约50个氨基酸至约110个氨基酸、约50个氨基酸至约100个氨基酸、约50个氨基酸至约90个氨基酸、约50个氨基酸至约80个氨基酸、约50个氨基酸至约70个氨基酸、约50个氨基酸至约60个氨基酸、约80个氨基酸至约800个氨基酸、约80个氨基酸至约790个氨基酸、约80个氨基酸至约780个氨基酸、约80个氨基酸至约770个氨基酸、约80个氨基酸至约760个氨基酸、约80个氨基酸至约750个氨基酸、约80个氨基酸至约740个氨基酸、约80个氨基酸至约730个氨基酸、约80个氨基酸至约720个氨基酸、约80个氨基酸至约710个氨基酸、约80个氨基酸至约700个氨基酸、约80个氨基酸至约690个氨基酸、约80个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约80个氨基酸至约660个氨基酸、约80个氨基酸至约650个氨基酸、约80个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约80个氨基酸至约620个氨基酸、约80个氨基酸至约610个氨基酸、约80个氨基酸至约600个氨基酸、约80个氨基酸至约590个氨基酸、约80个氨基酸至约580个氨基酸、约80个氨基酸至约570个氨基酸、约80个氨基酸至约560个氨基酸、约80个氨基酸至约550个氨基酸、约80个氨基酸至约540个氨基酸、约80个氨基酸至约530个氨基酸、约80个氨基酸至约520个氨基酸、约80个氨基酸至约510个氨基酸、约80个氨基酸至约500个氨基酸、约80个氨基酸至约490个氨基酸、约80个氨基酸至约480个氨基酸、约80个氨基酸至约470个氨基酸、约80个氨基酸至约460个氨基酸、约80个氨基酸至约450个氨基酸、约80个氨基酸至约440个氨基酸、约80个氨基酸至约430个氨基酸、约80个氨基酸至约420个氨基酸、约80个氨基酸至约410个氨基酸、约80个氨基酸至约400个氨基酸、约80个氨基酸至约390个氨基酸、约80个氨基酸至约380个氨基酸、约80个氨基酸至约370个氨基酸、约80个氨基酸至约360个氨基酸、约80个氨基酸至约350个氨基酸、约80个氨基酸至约340个氨基酸、约80个氨基酸至约330个氨基酸、约80个氨基酸至约320个氨基酸、约80个氨基酸至约310个氨基酸、约80个氨基酸至约300个氨基酸、约80个氨基酸至约290个氨基酸、约80个氨基酸至约280个氨基酸、约80个氨基酸至约270个氨基酸、约80个氨基酸至约260个氨基酸、约80个氨基酸至约250个氨基酸、约80个氨基酸至约240个氨基酸、约80个氨基酸至约230个氨基酸、约80个氨基酸至约220个氨基酸、约80个氨基酸至约210个氨基酸、约80个氨基酸至约200个氨基酸、约80个氨基酸至约190个氨基酸、约80个氨基酸至约180个氨基酸、约80个氨基酸至约170个氨基酸、约80个氨基酸至约160个氨基酸、约80个氨基酸至约150个氨基酸、约80个氨基酸至约140个氨基酸、约80个氨基酸至约130个氨基酸、约80个氨基酸至约120个氨基酸、约80个氨基酸至约110个氨基酸、约80个氨基酸至约100个氨基酸、约100个氨基酸至约800个氨基酸、约100个氨基酸至约790个氨基酸、约100个氨基酸至约780个氨基酸、约100个氨基酸至约770个氨基酸、约100个氨基酸至约760个氨基酸、约100个氨基酸至约750个氨基酸、约100个氨基酸至约740个氨基酸、约100个氨基酸至约730个氨基酸、约100个氨基酸至约720个氨基酸、约100个氨基酸至约710个氨基酸、约100个氨基酸至约700个氨基酸、约100个氨基酸至约690个氨基酸、约100个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约100个氨基酸至约660个氨基酸、约100个氨基酸至约650个氨基酸、约100个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约100个氨基酸至约620个氨基酸、约100个氨基酸至约610个氨基酸、约100个氨基酸至约600个氨基酸、约100个氨基酸至约590个氨基酸、约100个氨基酸至约580个氨基酸、约100个氨基酸至约570个氨基酸、约100个氨基酸至约560个氨基酸、约100个氨基酸至约550个氨基酸、约100个氨基酸至约540个氨基酸、约100个氨基酸至约530个氨基酸、约100个氨基酸至约520个氨基酸、约100个氨基酸至约510个氨基酸、约100个氨基酸至约500个氨基酸、约100个氨基酸至约490个氨基酸、约100个氨基酸至约480个氨基酸、约100个氨基酸至约470个氨基酸、约100个氨基酸至约460个氨基酸、约100个氨基酸至约450个氨基酸、约100个氨基酸至约440个氨基酸、约100个氨基酸至约430个氨基酸、约100个氨基酸至约420个氨基酸、约100个氨基酸至约410个氨基酸、约100个氨基酸至约400个氨基酸、约100个氨基酸至约390个氨基酸、约100个氨基酸至约380个氨基酸、约100个氨基酸至约370个氨基酸、约100个氨基酸至约360个氨基酸、约100个氨基酸至约350个氨基酸、约100个氨基酸至约340个氨基酸、约100个氨基酸至约330个氨基酸、约100个氨基酸至约320个氨基酸、约100个氨基酸至约310个氨基酸、约100个氨基酸至约300个氨基酸、约100个氨基酸至约290个氨基酸、约100个氨基酸至约280个氨基酸、约100个氨基酸至约270个氨基酸、约100个氨基酸至约260个氨基酸、约100个氨基酸至约250个氨基酸、约100个氨基酸至约240个氨基酸、约100个氨基酸至约230个氨基酸、约100个氨基酸至约220个氨基酸、约100个氨基酸至约210个氨基酸、约100个氨基酸至约200个氨基酸、约100个氨基酸至约190个氨基酸、约100个氨基酸至约180个氨基酸、约100个氨基酸至约170个氨基酸、约100个氨基酸至约160个氨基酸、约100个氨基酸至约150个氨基酸、约100个氨基酸至约140个氨基酸、约100个氨基酸至约130个氨基酸、约100个氨基酸至约120个氨基酸、约100个氨基酸至约110个氨基酸、约120个氨基酸至约800个氨基酸、约120个氨基酸至约790个氨基酸、约120个氨基酸至约780个氨基酸、约120个氨基酸至约770个氨基酸、约120个氨基酸至约760个氨基酸、约120个氨基酸至约750个氨基酸、约120个氨基酸至约740个氨基酸、约120个氨基酸至约730个氨基酸、约120个氨基酸至约720个氨基酸、约120个氨基酸至约710个氨基酸、约120个氨基酸至约700个氨基酸、约120个氨基酸至约690个氨基酸、约120个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约120个氨基酸至约660个氨基酸、约120个氨基酸至约650个氨基酸、约120个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约120个氨基酸至约620个氨基酸、约120个氨基酸至约610个氨基酸、约120个氨基酸至约600个氨基酸、约120个氨基酸至约590个氨基酸、约120个氨基酸至约580个氨基酸、约120个氨基酸至约570个氨基酸、约120个氨基酸至约560个氨基酸、约120个氨基酸至约550个氨基酸、约120个氨基酸至约540个氨基酸、约120个氨基酸至约530个氨基酸、约120个氨基酸至约520个氨基酸、约120个氨基酸至约510个氨基酸、约120个氨基酸至约500个氨基酸、约120个氨基酸至约490个氨基酸、约120个氨基酸至约480个氨基酸、约120个氨基酸至约470个氨基酸、约120个氨基酸至约460个氨基酸、约120个氨基酸至约450个氨基酸、约120个氨基酸至约440个氨基酸、约120个氨基酸至约430个氨基酸、约120个氨基酸至约420个氨基酸、约120个氨基酸至约410个氨基酸、约120个氨基酸至约400个氨基酸、约120个氨基酸至约390个氨基酸、约120个氨基酸至约380个氨基酸、约120个氨基酸至约370个氨基酸、约120个氨基酸至约360个氨基酸、约120个氨基酸至约350个氨基酸、约120个氨基酸至约340个氨基酸、约120个氨基酸至约330个氨基酸、约120个氨基酸至约320个氨基酸、约120个氨基酸至约310个氨基酸、约120个氨基酸至约300个氨基酸、约120个氨基酸至约290个氨基酸、约120个氨基酸至约280个氨基酸、约120个氨基酸至约270个氨基酸、约120个氨基酸至约260个氨基酸、约120个氨基酸至约250个氨基酸、约120个氨基酸至约240个氨基酸、约120个氨基酸至约230个氨基酸、约120个氨基酸至约220个氨基酸、约120个氨基酸至约210个氨基酸、约120个氨基酸至约200个氨基酸、约120个氨基酸至约190个氨基酸、约120个氨基酸至约180个氨基酸、约120个氨基酸至约170个氨基酸、约120个氨基酸至约160个氨基酸、约120个氨基酸至约150个氨基酸、约120个氨基酸至约140个氨基酸、约120个氨基酸至约130个氨基酸、约150个氨基酸至约800个氨基酸、约150个氨基酸至约790个氨基酸、约150个氨基酸至约780个氨基酸、约150个氨基酸至约770个氨基酸、约150个氨基酸至约760个氨基酸、约150个氨基酸至约750个氨基酸、约150个氨基酸至约740个氨基酸、约150个氨基酸至约730个氨基酸、约150个氨基酸至约720个氨基酸、约150个氨基酸至约710个氨基酸、约150个氨基酸至约700个氨基酸、约150个氨基酸至约690个氨基酸、约150个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约150个氨基酸至约660个氨基酸、约150个氨基酸至约650个氨基酸、约150个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约150个氨基酸至约620个氨基酸、约150个氨基酸至约610个氨基酸、约150个氨基酸至约600个氨基酸、约150个氨基酸至约590个氨基酸、约150个氨基酸至约580个氨基酸、约150个氨基酸至约570个氨基酸、约150个氨基酸至约560个氨基酸、约150个氨基酸至约550个氨基酸、约150个氨基酸至约540个氨基酸、约150个氨基酸至约530个氨基酸、约150个氨基酸至约520个氨基酸、约150个氨基酸至约510个氨基酸、约150个氨基酸至约500个氨基酸、约150个氨基酸至约490个氨基酸、约150个氨基酸至约480个氨基酸、约150个氨基酸至约470个氨基酸、约150个氨基酸至约460个氨基酸、约150个氨基酸至约450个氨基酸、约150个氨基酸至约440个氨基酸、约150个氨基酸至约430个氨基酸、约150个氨基酸至约420个氨基酸、约150个氨基酸至约410个氨基酸、约150个氨基酸至约400个氨基酸、约150个氨基酸至约390个氨基酸、约150个氨基酸至约380个氨基酸、约150个氨基酸至约370个氨基酸、约150个氨基酸至约360个氨基酸、约150个氨基酸至约350个氨基酸、约150个氨基酸至约340个氨基酸、约150个氨基酸至约330个氨基酸、约150个氨基酸至约320个氨基酸、约150个氨基酸至约310个氨基酸、约150个氨基酸至约300个氨基酸、约150个氨基酸至约290个氨基酸、约150个氨基酸至约280个氨基酸、约150个氨基酸至约270个氨基酸、约150个氨基酸至约260个氨基酸、约150个氨基酸至约250个氨基酸、约150个氨基酸至约240个氨基酸、约150个氨基酸至约230个氨基酸、约150个氨基酸至约220个氨基酸、约150个氨基酸至约210个氨基酸、约150个氨基酸至约200个氨基酸、约150个氨基酸至约190个氨基酸、约150个氨基酸至约180个氨基酸、约150个氨基酸至约170个氨基酸、约150个氨基酸至约160个氨基酸、约180个氨基酸至约800个氨基酸、约180个氨基酸至约790个氨基酸、约180个氨基酸至约780个氨基酸、约180个氨基酸至约770个氨基酸、约180个氨基酸至约760个氨基酸、约180个氨基酸至约750个氨基酸、约180个氨基酸至约740个氨基酸、约180个氨基酸至约730个氨基酸、约180个氨基酸至约720个氨基酸、约180个氨基酸至约710个氨基酸、约180个氨基酸至约700个氨基酸、约180个氨基酸至约690个氨基酸、约180个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约180个氨基酸至约660个氨基酸、约180个氨基酸至约650个氨基酸、约180个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约180个氨基酸至约620个氨基酸、约180个氨基酸至约610个氨基酸、约180个氨基酸至约600个氨基酸、约180个氨基酸至约590个氨基酸、约180个氨基酸至约580个氨基酸、约180个氨基酸至约570个氨基酸、约180个氨基酸至约560个氨基酸、约180个氨基酸至约550个氨基酸、约180个氨基酸至约540个氨基酸、约180个氨基酸至约530个氨基酸、约180个氨基酸至约520个氨基酸、约180个氨基酸至约510个氨基酸、约180个氨基酸至约500个氨基酸、约180个氨基酸至约490个氨基酸、约180个氨基酸至约480个氨基酸、约180个氨基酸至约470个氨基酸、约180个氨基酸至约460个氨基酸、约180个氨基酸至约450个氨基酸、约180个氨基酸至约440个氨基酸、约180个氨基酸至约430个氨基酸、约180个氨基酸至约420个氨基酸、约180个氨基酸至约410个氨基酸、约180个氨基酸至约400个氨基酸、约180个氨基酸至约390个氨基酸、约180个氨基酸至约380个氨基酸、约180个氨基酸至约370个氨基酸、约180个氨基酸至约360个氨基酸、约180个氨基酸至约350个氨基酸、约180个氨基酸至约340个氨基酸、约180个氨基酸至约330个氨基酸、约180个氨基酸至约320个氨基酸、约180个氨基酸至约310个氨基酸、约180个氨基酸至约300个氨基酸、约180个氨基酸至约290个氨基酸、约180个氨基酸至约280个氨基酸、约180个氨基酸至约270个氨基酸、约180个氨基酸至约260个氨基酸、约180个氨基酸至约250个氨基酸、约180个氨基酸至约240个氨基酸、约180个氨基酸至约230个氨基酸、约180个氨基酸至约220个氨基酸、约180个氨基酸至约210个氨基酸、约180个氨基酸至约200个氨基酸、约180个氨基酸至约190个氨基酸、约200个氨基酸至约800个氨基酸、约200个氨基酸至约790个氨基酸、约200个氨基酸至约780个氨基酸、约200个氨基酸至约770个氨基酸、约200个氨基酸至约760个氨基酸、约200个氨基酸至约750个氨基酸、约200个氨基酸至约740个氨基酸、约200个氨基酸至约730个氨基酸、约200个氨基酸至约720个氨基酸、约200个氨基酸至约710个氨基酸、约200个氨基酸至约700个氨基酸、约200个氨基酸至约690个氨基酸、约200个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约200个氨基酸至约660个氨基酸、约200个氨基酸至约650个氨基酸、约200个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约200个氨基酸至约620个氨基酸、约200个氨基酸至约610个氨基酸、约200个氨基酸至约600个氨基酸、约200个氨基酸至约590个氨基酸、约200个氨基酸至约580个氨基酸、约200个氨基酸至约570个氨基酸、约200个氨基酸至约560个氨基酸、约200个氨基酸至约550个氨基酸、约200个氨基酸至约540个氨基酸、约200个氨基酸至约530个氨基酸、约200个氨基酸至约520个氨基酸、约200个氨基酸至约510个氨基酸、约200个氨基酸至约500个氨基酸、约200个氨基酸至约490个氨基酸、约200个氨基酸至约480个氨基酸、约200个氨基酸至约470个氨基酸、约200个氨基酸至约460个氨基酸、约200个氨基酸至约450个氨基酸、约200个氨基酸至约440个氨基酸、约200个氨基酸至约430个氨基酸、约200个氨基酸至约420个氨基酸、约200个氨基酸至约410个氨基酸、约200个氨基酸至约400个氨基酸、约200个氨基酸至约390个氨基酸、约200个氨基酸至约380个氨基酸、约200个氨基酸至约370个氨基酸、约200个氨基酸至约360个氨基酸、约200个氨基酸至约350个氨基酸、约200个氨基酸至约340个氨基酸、约200个氨基酸至约330个氨基酸、约200个氨基酸至约320个氨基酸、约200个氨基酸至约310个氨基酸、约200个氨基酸至约300个氨基酸、约200个氨基酸至约290个氨基酸、约200个氨基酸至约280个氨基酸、约200个氨基酸至约270个氨基酸、约200个氨基酸至约260个氨基酸、约200个氨基酸至约250个氨基酸、约200个氨基酸至约240个氨基酸、约200个氨基酸至约230个氨基酸、约200个氨基酸至约220个氨基酸、约200个氨基酸至约210个氨基酸、约250个氨基酸至约800个氨基酸、约250个氨基酸至约790个氨基酸、约250个氨基酸至约780个氨基酸、约250个氨基酸至约770个氨基酸、约250个氨基酸至约760个氨基酸、约250个氨基酸至约750个氨基酸、约250个氨基酸至约740个氨基酸、约250个氨基酸至约730个氨基酸、约250个氨基酸至约720个氨基酸、约250个氨基酸至约710个氨基酸、约250个氨基酸至约700个氨基酸、约250个氨基酸至约690个氨基酸、约250个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约250个氨基酸至约660个氨基酸、约250个氨基酸至约650个氨基酸、约250个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约250个氨基酸至约620个氨基酸、约250个氨基酸至约610个氨基酸、约250个氨基酸至约600个氨基酸、约250个氨基酸至约590个氨基酸、约250个氨基酸至约580个氨基酸、约250个氨基酸至约570个氨基酸、约250个氨基酸至约560个氨基酸、约250个氨基酸至约550个氨基酸、约250个氨基酸至约540个氨基酸、约250个氨基酸至约530个氨基酸、约250个氨基酸至约520个氨基酸、约250个氨基酸至约510个氨基酸、约250个氨基酸至约500个氨基酸、约250个氨基酸至约490个氨基酸、约250个氨基酸至约480个氨基酸、约250个氨基酸至约470个氨基酸、约250个氨基酸至约460个氨基酸、约250个氨基酸至约450个氨基酸、约250个氨基酸至约440个氨基酸、约250个氨基酸至约430个氨基酸、约250个氨基酸至约420个氨基酸、约250个氨基酸至约410个氨基酸、约250个氨基酸至约400个氨基酸、约250个氨基酸至约390个氨基酸、约250个氨基酸至约380个氨基酸、约250个氨基酸至约370个氨基酸、约250个氨基酸至约360个氨基酸、约250个氨基酸至约350个氨基酸、约250个氨基酸至约340个氨基酸、约250个氨基酸至约330个氨基酸、约250个氨基酸至约320个氨基酸、约250个氨基酸至约310个氨基酸、约250个氨基酸至约300个氨基酸、约250个氨基酸至约290个氨基酸、约250个氨基酸至约280个氨基酸、约250个氨基酸至约270个氨基酸、约250个氨基酸至约260个氨基酸、约280个氨基酸至约800个氨基酸、约280个氨基酸至约790个氨基酸、约280个氨基酸至约780个氨基酸、约280个氨基酸至约770个氨基酸、约280个氨基酸至约760个氨基酸、约280个氨基酸至约750个氨基酸、约280个氨基酸至约740个氨基酸、约280个氨基酸至约730个氨基酸、约280个氨基酸至约720个氨基酸、约280个氨基酸至约710个氨基酸、约280个氨基酸至约700个氨基酸、约280个氨基酸至约690个氨基酸、约280个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约280个氨基酸至约660个氨基酸、约280个氨基酸至约650个氨基酸、约280个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约280个氨基酸至约620个氨基酸、约280个氨基酸至约610个氨基酸、约280个氨基酸至约600个氨基酸、约280个氨基酸至约590个氨基酸、约280个氨基酸至约580个氨基酸、约280个氨基酸至约570个氨基酸、约280个氨基酸至约560个氨基酸、约280个氨基酸至约550个氨基酸、约280个氨基酸至约540个氨基酸、约280个氨基酸至约530个氨基酸、约280个氨基酸至约520个氨基酸、约280个氨基酸至约510个氨基酸、约280个氨基酸至约500个氨基酸、约280个氨基酸至约490个氨基酸、约280个氨基酸至约480个氨基酸、约280个氨基酸至约470个氨基酸、约280个氨基酸至约460个氨基酸、约280个氨基酸至约450个氨基酸、约280个氨基酸至约440个氨基酸、约280个氨基酸至约430个氨基酸、约280个氨基酸至约420个氨基酸、约280个氨基酸至约410个氨基酸、约280个氨基酸至约400个氨基酸、约280个氨基酸至约390个氨基酸、约280个氨基酸至约380个氨基酸、约280个氨基酸至约370个氨基酸、约280个氨基酸至约360个氨基酸、约280个氨基酸至约350个氨基酸、约280个氨基酸至约340个氨基酸、约280个氨基酸至约330个氨基酸、约280个氨基酸至约320个氨基酸、约280个氨基酸至约310个氨基酸、约280个氨基酸至约300个氨基酸、约300个氨基酸至约800个氨基酸、约300个氨基酸至约790个氨基酸、约300个氨基酸至约780个氨基酸、约300个氨基酸至约770个氨基酸、约300个氨基酸至约760个氨基酸、约300个氨基酸至约750个氨基酸、约300个氨基酸至约740个氨基酸、约300个氨基酸至约730个氨基酸、约300个氨基酸至约720个氨基酸、约300个氨基酸至约710个氨基酸、约300个氨基酸至约700个氨基酸、约300个氨基酸至约690个氨基酸、约300个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约300个氨基酸至约660个氨基酸、约300个氨基酸至约650个氨基酸、约300个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约300个氨基酸至约620个氨基酸、约300个氨基酸至约610个氨基酸、约300个氨基酸至约600个氨基酸、约300个氨基酸至约590个氨基酸、约300个氨基酸至约580个氨基酸、约300个氨基酸至约570个氨基酸、约300个氨基酸至约560个氨基酸、约300个氨基酸至约550个氨基酸、约300个氨基酸至约540个氨基酸、约300个氨基酸至约530个氨基酸、约300个氨基酸至约520个氨基酸、约300个氨基酸至约510个氨基酸、约300个氨基酸至约500个氨基酸、约300个氨基酸至约490个氨基酸、约300个氨基酸至约480个氨基酸、约300个氨基酸至约470个氨基酸、约300个氨基酸至约460个氨基酸、约300个氨基酸至约450个氨基酸、约300个氨基酸至约440个氨基酸、约300个氨基酸至约430个氨基酸、约300个氨基酸至约420个氨基酸、约300个氨基酸至约410个氨基酸、约300个氨基酸至约400个氨基酸、约300个氨基酸至约390个氨基酸、约300个氨基酸至约380个氨基酸、约300个氨基酸至约370个氨基酸、约300个氨基酸至约360个氨基酸、约300个氨基酸至约350个氨基酸、约300个氨基酸至约340个氨基酸、约300个氨基酸至约330个氨基酸、约300个氨基酸至约320个氨基酸、约300个氨基酸至约310个氨基酸、约350个氨基酸至约800个氨基酸、约350个氨基酸至约790个氨基酸、约350个氨基酸至约780个氨基酸、约350个氨基酸至约770个氨基酸、约350个氨基酸至约760个氨基酸、约350个氨基酸至约750个氨基酸、约350个氨基酸至约740个氨基酸、约350个氨基酸至约730个氨基酸、约350个氨基酸至约720个氨基酸、约350个氨基酸至约710个氨基酸、约350个氨基酸至约700个氨基酸、约350个氨基酸至约690个氨基酸、约350个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约350个氨基酸至约660个氨基酸、约350个氨基酸至约650个氨基酸、约350个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约350个氨基酸至约620个氨基酸、约350个氨基酸至约610个氨基酸、约350个氨基酸至约600个氨基酸、约350个氨基酸至约590个氨基酸、约350个氨基酸至约580个氨基酸、约350个氨基酸至约570个氨基酸、约350个氨基酸至约560个氨基酸、约350个氨基酸至约550个氨基酸、约350个氨基酸至约540个氨基酸、约350个氨基酸至约530个氨基酸、约350个氨基酸至约520个氨基酸、约350个氨基酸至约510个氨基酸、约350个氨基酸至约500个氨基酸、约350个氨基酸至约490个氨基酸、约350个氨基酸至约480个氨基酸、约350个氨基酸至约470个氨基酸、约350个氨基酸至约460个氨基酸、约350个氨基酸至约450个氨基酸、约350个氨基酸至约440个氨基酸、约350个氨基酸至约430个氨基酸、约350个氨基酸至约420个氨基酸、约350个氨基酸至约410个氨基酸、约350个氨基酸至约400个氨基酸、约350个氨基酸至约390个氨基酸、约350个氨基酸至约380个氨基酸、约350个氨基酸至约370个氨基酸、约350个氨基酸至约360个氨基酸、约380个氨基酸至约800个氨基酸、约380个氨基酸至约790个氨基酸、约380个氨基酸至约780个氨基酸、约380个氨基酸至约770个氨基酸、约380个氨基酸至约760个氨基酸、约380个氨基酸至约750个氨基酸、约380个氨基酸至约740个氨基酸、约380个氨基酸至约730个氨基酸、约380个氨基酸至约720个氨基酸、约380个氨基酸至约710个氨基酸、约380个氨基酸至约700个氨基酸、约380个氨基酸至约690个氨基酸、约380个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约380个氨基酸至约660个氨基酸、约380个氨基酸至约650个氨基酸、约380个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约380个氨基酸至约620个氨基酸、约380个氨基酸至约610个氨基酸、约380个氨基酸至约600个氨基酸、约380个氨基酸至约590个氨基酸、约380个氨基酸至约580个氨基酸、约380个氨基酸至约570个氨基酸、约380个氨基酸至约560个氨基酸、约380个氨基酸至约550个氨基酸、约380个氨基酸至约540个氨基酸、约380个氨基酸至约530个氨基酸、约380个氨基酸至约520个氨基酸、约380个氨基酸至约510个氨基酸、约380个氨基酸至约500个氨基酸、约380个氨基酸至约490个氨基酸、约380个氨基酸至约480个氨基酸、约380个氨基酸至约470个氨基酸、约380个氨基酸至约460个氨基酸、约380个氨基酸至约450个氨基酸、约380个氨基酸至约440个氨基酸、约380个氨基酸至约430个氨基酸、约380个氨基酸至约420个氨基酸、约380个氨基酸至约410个氨基酸、约380个氨基酸至约400个氨基酸、约380个氨基酸至约390个氨基酸、约400个氨基酸至约800个氨基酸、约400个氨基酸至约790个氨基酸、约400个氨基酸至约780个氨基酸、约400个氨基酸至约770个氨基酸、约400个氨基酸至约760个氨基酸、约400个氨基酸至约750个氨基酸、约400个氨基酸至约740个氨基酸、约400个氨基酸至约730个氨基酸、约400个氨基酸至约720个氨基酸、约400个氨基酸至约710个氨基酸、约400个氨基酸至约700个氨基酸、约400个氨基酸至约690个氨基酸、约400个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约400个氨基酸至约660个氨基酸、约400个氨基酸至约650个氨基酸、约400个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约400个氨基酸至约620个氨基酸、约400个氨基酸至约610个氨基酸、约400个氨基酸至约600个氨基酸、约400个氨基酸至约590个氨基酸、约400个氨基酸至约580个氨基酸、约400个氨基酸至约570个氨基酸、约400个氨基酸至约560个氨基酸、约400个氨基酸至约550个氨基酸、约400个氨基酸至约540个氨基酸、约400个氨基酸至约530个氨基酸、约400个氨基酸至约520个氨基酸、约400个氨基酸至约510个氨基酸、约400个氨基酸至约500个氨基酸、约400个氨基酸至约490个氨基酸、约400个氨基酸至约480个氨基酸、约400个氨基酸至约470个氨基酸、约400个氨基酸至约460个氨基酸、约400个氨基酸至约450个氨基酸、约400个氨基酸至约440个氨基酸、约400个氨基酸至约430个氨基酸、约400个氨基酸至约420个氨基酸、约400个氨基酸至约410个氨基酸、约450个氨基酸至约800个氨基酸、约450个氨基酸至约790个氨基酸、约450个氨基酸至约780个氨基酸、约450个氨基酸至约770个氨基酸、约450个氨基酸至约760个氨基酸、约450个氨基酸至约750个氨基酸、约450个氨基酸至约740个氨基酸、约450个氨基酸至约730个氨基酸、约450个氨基酸至约720个氨基酸、约450个氨基酸至约710个氨基酸、约450个氨基酸至约700个氨基酸、约450个氨基酸至约690个氨基酸、约450个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约450个氨基酸至约660个氨基酸、约450个氨基酸至约650个氨基酸、约450个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约450个氨基酸至约620个氨基酸、约450个氨基酸至约610个氨基酸、约450个氨基酸至约600个氨基酸、约450个氨基酸至约590个氨基酸、约450个氨基酸至约580个氨基酸、约450个氨基酸至约570个氨基酸、约450个氨基酸至约560个氨基酸、约450个氨基酸至约550个氨基酸、约450个氨基酸至约540个氨基酸、约450个氨基酸至约530个氨基酸、约450个氨基酸至约520个氨基酸、约450个氨基酸至约510个氨基酸、约450个氨基酸至约500个氨基酸、约450个氨基酸至约490个氨基酸、约450个氨基酸至约480个氨基酸、约450个氨基酸至约470个氨基酸、约450个氨基酸至约460个氨基酸、约480个氨基酸至约800个氨基酸、约480个氨基酸至约790个氨基酸、约480个氨基酸至约780个氨基酸、约480个氨基酸至约770个氨基酸、约480个氨基酸至约760个氨基酸、约480个氨基酸至约750个氨基酸、约480个氨基酸至约740个氨基酸、约480个氨基酸至约730个氨基酸、约480个氨基酸至约720个氨基酸、约480个氨基酸至约710个氨基酸、约480个氨基酸至约700个氨基酸、约480个氨基酸至约690个氨基酸、约480个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约480个氨基酸至约660个氨基酸、约480个氨基酸至约650个氨基酸、约480个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约480个氨基酸至约620个氨基酸、约480个氨基酸至约610个氨基酸、约480个氨基酸至约600个氨基酸、约480个氨基酸至约590个氨基酸、约480个氨基酸至约580个氨基酸、约480个氨基酸至约570个氨基酸、约480个氨基酸至约560个氨基酸、约480个氨基酸至约550个氨基酸、约480个氨基酸至约540个氨基酸、约480个氨基酸至约530个氨基酸、约480个氨基酸至约520个氨基酸、约480个氨基酸至约510个氨基酸、约480个氨基酸至约500个氨基酸、约480个氨基酸至约490个氨基酸、约50个氨基酸至约800个氨基酸、约50个氨基酸至约790个氨基酸、约50个氨基酸至约780个氨基酸、约50个氨基酸至约770个氨基酸、约50个氨基酸至约760个氨基酸、约50个氨基酸至约750个氨基酸、约50个氨基酸至约740个氨基酸、约50个氨基酸至约730个氨基酸、约50个氨基酸至约720个氨基酸、约50个氨基酸至约710个氨基酸、约50个氨基酸至约700个氨基酸、约50个氨基酸至约690个氨基酸、约50个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约50个氨基酸至约660个氨基酸、约50个氨基酸至约650个氨基酸、约50个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约50个氨基酸至约620个氨基酸、约50个氨基酸至约610个氨基酸、约50个氨基酸至约600个氨基酸、约50个氨基酸至约590个氨基酸、约50个氨基酸至约580个氨基酸、约50个氨基酸至约570个氨基酸、约50个氨基酸至约560个氨基酸、约50个氨基酸至约550个氨基酸、约50个氨基酸至约540个氨基酸、约50个氨基酸至约530个氨基酸、约50个氨基酸至约520个氨基酸、约50个氨基酸至约510个氨基酸、约550个氨基酸至约800个氨基酸、约550个氨基酸至约790个氨基酸、约550个氨基酸至约780个氨基酸、约550个氨基酸至约770个氨基酸、约550个氨基酸至约760个氨基酸、约550个氨基酸至约750个氨基酸、约550个氨基酸至约740个氨基酸、约550个氨基酸至约730个氨基酸、约550个氨基酸至约720个氨基酸、约550个氨基酸至约710个氨基酸、约550个氨基酸至约700个氨基酸、约550个氨基酸至约690个氨基酸、约550个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约550个氨基酸至约660个氨基酸、约550个氨基酸至约650个氨基酸、约550个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约550个氨基酸至约620个氨基酸、约550个氨基酸至约610个氨基酸、约550个氨基酸至约600个氨基酸、约550个氨基酸至约590个氨基酸、约550个氨基酸至约580个氨基酸、约550个氨基酸至约570个氨基酸、约550个氨基酸至约560个氨基酸、约580个氨基酸至约800个氨基酸、约580个氨基酸至约790个氨基酸、约580个氨基酸至约780个氨基酸、约580个氨基酸至约770个氨基酸、约580个氨基酸至约760个氨基酸、约580个氨基酸至约750个氨基酸、约580个氨基酸至约740个氨基酸、约580个氨基酸至约730个氨基酸、约580个氨基酸至约720个氨基酸、约580个氨基酸至约710个氨基酸、约580个氨基酸至约700个氨基酸、约580个氨基酸至约690个氨基酸、约580个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约580个氨基酸至约660个氨基酸、约580个氨基酸至约650个氨基酸、约580个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约580个氨基酸至约620个氨基酸、约580个氨基酸至约610个氨基酸、约580个氨基酸至约600个氨基酸、约580个氨基酸至约590个氨基酸、约600个氨基酸至约800个氨基酸、约600个氨基酸至约790个氨基酸、约600个氨基酸至约780个氨基酸、约600个氨基酸至约770个氨基酸、约600个氨基酸至约760个氨基酸、约600个氨基酸至约750个氨基酸、约600个氨基酸至约740个氨基酸、约600个氨基酸至约730个氨基酸、约600个氨基酸至约720个氨基酸、约600个氨基酸至约710个氨基酸、约600个氨基酸至约700个氨基酸、约600个氨基酸至约690个氨基酸、约600个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约600个氨基酸至约660个氨基酸、约600个氨基酸至约650个氨基酸、约600个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约600个氨基酸至约620个氨基酸、约600个氨基酸至约610个氨基酸、约650个氨基酸至约800个氨基酸、约650个氨基酸至约790个氨基酸、约650个氨基酸至约780个氨基酸、约650个氨基酸至约770个氨基酸、约650个氨基酸至约760个氨基酸、约650个氨基酸至约750个氨基酸、约650个氨基酸至约740个氨基酸、约650个氨基酸至约730个氨基酸、约650个氨基酸至约720个氨基酸、约650个氨基酸至约710个氨基酸、约650个氨基酸至约700个氨基酸、约650个氨基酸至约690个氨基酸、约650个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约650个氨基酸至约660个氨基酸、约680个氨基酸至约800个氨基酸、约680个氨基酸至约790个氨基酸、约680个氨基酸至约780个氨基酸、约680个氨基酸至约770个氨基酸、约680个氨基酸至约760个氨基酸、约680个氨基酸至约750个氨基酸、约680个氨基酸至约740个氨基酸、约680个氨基酸至约730个氨基酸、约680个氨基酸至约720个氨基酸、约680个氨基酸至约710个氨基酸、约680个氨基酸至约700个氨基酸、约680个氨基酸至约690个氨基酸、约700个氨基酸至约800个氨基酸、约700个氨基酸至约790个氨基酸、约700个氨基酸至约780个氨基酸、约700个氨基酸至约770个氨基酸、约700个氨基酸至约760个氨基酸、约700个氨基酸至约750个氨基酸、约700个氨基酸至约740个氨基酸、约700个氨基酸至约730个氨基酸、约700个氨基酸至约720个氨基酸、约700个氨基酸至约710个氨基酸、约750个氨基酸至约800个氨基酸、约750个氨基酸至约790个氨基酸、约750个氨基酸至约780个氨基酸、约750个氨基酸至约770个氨基酸、约750个氨基酸至约760个氨基酸或约780个氨基酸至约800个氨基酸)。在一些实例中，第一载体还包含启动子(例如，本文所述的或本领域已知的任何启动子)和Kozak序列(例如，本文所述的或本领域已知的任何示例性Kozak序列)之一者或两者。在一些实例中，第一载体包含启动子，所述启动子为诱导型启动子、组成型启动子或组织特异性启动子。在一些实例中，所述两种不同的载体中的第二载体包含编码靶蛋白的C末端部分(例如，支持细胞靶蛋白的C末端部分或毛细胞靶蛋白的C末端部分)的编码序列。在一些实例中，靶蛋白的C末端部分(例如，支持细胞靶蛋白的C末端部分或毛细胞靶蛋白的C末端部分)的长度为约30个氨基酸至约800个氨基酸(例如，约30个氨基酸至约790个氨基酸、约30个氨基酸至约780个氨基酸、约30个氨基酸至约770个氨基酸、约30个氨基酸至约760个氨基酸、约30个氨基酸至约750个氨基酸、约30个氨基酸至约740个氨基酸、约30个氨基酸至约730个氨基酸、约30个氨基酸至约720个氨基酸、约30个氨基酸至约710个氨基酸、约30个氨基酸至约700个氨基酸、约30个氨基酸至约690个氨基酸、约30个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约30个氨基酸至约660个氨基酸、约30个氨基酸至约650个氨基酸、约30个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约30个氨基酸至约620个氨基酸、约30个氨基酸至约610个氨基酸、约30个氨基酸至约600个氨基酸、约30个氨基酸至约590个氨基酸、约30个氨基酸至约580个氨基酸、约30个氨基酸至约570个氨基酸、约30个氨基酸至约560个氨基酸、约30个氨基酸至约550个氨基酸、约30个氨基酸至约540个氨基酸、约30个氨基酸至约530个氨基酸、约30个氨基酸至约520个氨基酸、约30个氨基酸至约510个氨基酸、约30个氨基酸至约500个氨基酸、约30个氨基酸至约490个氨基酸、约30个氨基酸至约480个氨基酸、约30个氨基酸至约470个氨基酸、约30个氨基酸至约460个氨基酸、约30个氨基酸至约450个氨基酸、约30个氨基酸至约440个氨基酸、约30个氨基酸至约430个氨基酸、约30个氨基酸至约420个氨基酸、约30个氨基酸至约410个氨基酸、约30个氨基酸至约400个氨基酸、约30个氨基酸至约390个氨基酸、约30个氨基酸至约380个氨基酸、约30个氨基酸至约370个氨基酸、约30个氨基酸至约360个氨基酸、约30个氨基酸至约350个氨基酸、约30个氨基酸至约340个氨基酸、约30个氨基酸至约330个氨基酸、约30个氨基酸至约320个氨基酸、约30个氨基酸至约310个氨基酸、约30个氨基酸至约300个氨基酸、约30个氨基酸至约290个氨基酸、约30个氨基酸至约280个氨基酸、约30个氨基酸至约270个氨基酸、约30个氨基酸至约260个氨基酸、约30个氨基酸至约250个氨基酸、约30个氨基酸至约240个氨基酸、约30个氨基酸至约230个氨基酸、约30个氨基酸至约220个氨基酸、约30个氨基酸至约210个氨基酸、约30个氨基酸至约200个氨基酸、约30个氨基酸至约190个氨基酸、约30个氨基酸至约180个氨基酸、约30个氨基酸至约170个氨基酸、约30个氨基酸至约160个氨基酸、约30个氨基酸至约150个氨基酸、约30个氨基酸至约140个氨基酸、约30个氨基酸至约130个氨基酸、约30个氨基酸至约120个氨基酸、约30个氨基酸至约110个氨基酸、约30个氨基酸至约100个氨基酸、约30个氨基酸至约90个氨基酸、约30个氨基酸至约80个氨基酸、约30个氨基酸至约70个氨基酸、约30个氨基酸至约60个氨基酸、约30个氨基酸至约50个氨基酸、约30个氨基酸至约40个氨基酸、约50个氨基酸至约800个氨基酸、约50个氨基酸至约790个氨基酸、约50个氨基酸至约780个氨基酸、约50个氨基酸至约770个氨基酸、约50个氨基酸至约760个氨基酸、约50个氨基酸至约750个氨基酸、约50个氨基酸至约740个氨基酸、约50个氨基酸至约730个氨基酸、约50个氨基酸至约720个氨基酸、约50个氨基酸至约710个氨基酸、约50个氨基酸至约700个氨基酸、约50个氨基酸至约690个氨基酸、约50个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约50个氨基酸至约660个氨基酸、约50个氨基酸至约650个氨基酸、约50个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约50个氨基酸至约620个氨基酸、约50个氨基酸至约610个氨基酸、约50个氨基酸至约600个氨基酸、约50个氨基酸至约590个氨基酸、约50个氨基酸至约580个氨基酸、约50个氨基酸至约570个氨基酸、约50个氨基酸至约560个氨基酸、约50个氨基酸至约550个氨基酸、约50个氨基酸至约540个氨基酸、约50个氨基酸至约530个氨基酸、约50个氨基酸至约520个氨基酸、约50个氨基酸至约510个氨基酸、约50个氨基酸至约500个氨基酸、约50个氨基酸至约490个氨基酸、约50个氨基酸至约480个氨基酸、约50个氨基酸至约470个氨基酸、约50个氨基酸至约460个氨基酸、约50个氨基酸至约450个氨基酸、约50个氨基酸至约440个氨基酸、约50个氨基酸至约430个氨基酸、约50个氨基酸至约420个氨基酸、约50个氨基酸至约410个氨基酸、约50个氨基酸至约400个氨基酸、约50个氨基酸至约390个氨基酸、约50个氨基酸至约380个氨基酸、约50个氨基酸至约370个氨基酸、约50个氨基酸至约360个氨基酸、约50个氨基酸至约350个氨基酸、约50个氨基酸至约340个氨基酸、约50个氨基酸至约330个氨基酸、约50个氨基酸至约320个氨基酸、约50个氨基酸至约310个氨基酸、约50个氨基酸至约300个氨基酸、约50个氨基酸至约290个氨基酸、约50个氨基酸至约280个氨基酸、约50个氨基酸至约270个氨基酸、约50个氨基酸至约260个氨基酸、约50个氨基酸至约250个氨基酸、约50个氨基酸至约240个氨基酸、约50个氨基酸至约230个氨基酸、约50个氨基酸至约220个氨基酸、约50个氨基酸至约210个氨基酸、约50个氨基酸至约200个氨基酸、约50个氨基酸至约190个氨基酸、约50个氨基酸至约180个氨基酸、约50个氨基酸至约170个氨基酸、约50个氨基酸至约160个氨基酸、约50个氨基酸至约150个氨基酸、约50个氨基酸至约140个氨基酸、约50个氨基酸至约130个氨基酸、约50个氨基酸至约120个氨基酸、约50个氨基酸至约110个氨基酸、约50个氨基酸至约100个氨基酸、约50个氨基酸至约90个氨基酸、约50个氨基酸至约80个氨基酸、约50个氨基酸至约70个氨基酸、约50个氨基酸至约60个氨基酸、约80个氨基酸至约800个氨基酸、约80个氨基酸至约790个氨基酸、约80个氨基酸至约780个氨基酸、约80个氨基酸至约770个氨基酸、约80个氨基酸至约760个氨基酸、约80个氨基酸至约750个氨基酸、约80个氨基酸至约740个氨基酸、约80个氨基酸至约730个氨基酸、约80个氨基酸至约720个氨基酸、约80个氨基酸至约710个氨基酸、约80个氨基酸至约700个氨基酸、约80个氨基酸至约690个氨基酸、约80个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约80个氨基酸至约660个氨基酸、约80个氨基酸至约650个氨基酸、约80个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约80个氨基酸至约620个氨基酸、约80个氨基酸至约610个氨基酸、约80个氨基酸至约600个氨基酸、约80个氨基酸至约590个氨基酸、约80个氨基酸至约580个氨基酸、约80个氨基酸至约570个氨基酸、约80个氨基酸至约560个氨基酸、约80个氨基酸至约550个氨基酸、约80个氨基酸至约540个氨基酸、约80个氨基酸至约530个氨基酸、约80个氨基酸至约520个氨基酸、约80个氨基酸至约510个氨基酸、约80个氨基酸至约500个氨基酸、约80个氨基酸至约490个氨基酸、约80个氨基酸至约480个氨基酸、约80个氨基酸至约470个氨基酸、约80个氨基酸至约460个氨基酸、约80个氨基酸至约450个氨基酸、约80个氨基酸至约440个氨基酸、约80个氨基酸至约430个氨基酸、约80个氨基酸至约420个氨基酸、约80个氨基酸至约410个氨基酸、约80个氨基酸至约400个氨基酸、约80个氨基酸至约390个氨基酸、约80个氨基酸至约380个氨基酸、约80个氨基酸至约370个氨基酸、约80个氨基酸至约360个氨基酸、约80个氨基酸至约350个氨基酸、约80个氨基酸至约340个氨基酸、约80个氨基酸至约330个氨基酸、约80个氨基酸至约320个氨基酸、约80个氨基酸至约310个氨基酸、约80个氨基酸至约300个氨基酸、约80个氨基酸至约290个氨基酸、约80个氨基酸至约280个氨基酸、约80个氨基酸至约270个氨基酸、约80个氨基酸至约260个氨基酸、约80个氨基酸至约250个氨基酸、约80个氨基酸至约240个氨基酸、约80个氨基酸至约230个氨基酸、约80个氨基酸至约220个氨基酸、约80个氨基酸至约210个氨基酸、约80个氨基酸至约200个氨基酸、约80个氨基酸至约190个氨基酸、约80个氨基酸至约180个氨基酸、约80个氨基酸至约170个氨基酸、约80个氨基酸至约160个氨基酸、约80个氨基酸至约150个氨基酸、约80个氨基酸至约140个氨基酸、约80个氨基酸至约130个氨基酸、约80个氨基酸至约120个氨基酸、约80个氨基酸至约110个氨基酸、约80个氨基酸至约100个氨基酸、约100个氨基酸至约800个氨基酸、约100个氨基酸至约790个氨基酸、约100个氨基酸至约780个氨基酸、约100个氨基酸至约770个氨基酸、约100个氨基酸至约760个氨基酸、约100个氨基酸至约750个氨基酸、约100个氨基酸至约740个氨基酸、约100个氨基酸至约730个氨基酸、约100个氨基酸至约720个氨基酸、约100个氨基酸至约710个氨基酸、约100个氨基酸至约700个氨基酸、约100个氨基酸至约690个氨基酸、约100个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约100个氨基酸至约660个氨基酸、约100个氨基酸至约650个氨基酸、约100个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约100个氨基酸至约620个氨基酸、约100个氨基酸至约610个氨基酸、约100个氨基酸至约600个氨基酸、约100个氨基酸至约590个氨基酸、约100个氨基酸至约580个氨基酸、约100个氨基酸至约570个氨基酸、约100个氨基酸至约560个氨基酸、约100个氨基酸至约550个氨基酸、约100个氨基酸至约540个氨基酸、约100个氨基酸至约530个氨基酸、约100个氨基酸至约520个氨基酸、约100个氨基酸至约510个氨基酸、约100个氨基酸至约500个氨基酸、约100个氨基酸至约490个氨基酸、约100个氨基酸至约480个氨基酸、约100个氨基酸至约470个氨基酸、约100个氨基酸至约460个氨基酸、约100个氨基酸至约450个氨基酸、约100个氨基酸至约440个氨基酸、约100个氨基酸至约430个氨基酸、约100个氨基酸至约420个氨基酸、约100个氨基酸至约410个氨基酸、约100个氨基酸至约400个氨基酸、约100个氨基酸至约390个氨基酸、约100个氨基酸至约380个氨基酸、约100个氨基酸至约370个氨基酸、约100个氨基酸至约360个氨基酸、约100个氨基酸至约350个氨基酸、约100个氨基酸至约340个氨基酸、约100个氨基酸至约330个氨基酸、约100个氨基酸至约320个氨基酸、约100个氨基酸至约310个氨基酸、约100个氨基酸至约300个氨基酸、约100个氨基酸至约290个氨基酸、约100个氨基酸至约280个氨基酸、约100个氨基酸至约270个氨基酸、约100个氨基酸至约260个氨基酸、约100个氨基酸至约250个氨基酸、约100个氨基酸至约240个氨基酸、约100个氨基酸至约230个氨基酸、约100个氨基酸至约220个氨基酸、约100个氨基酸至约210个氨基酸、约100个氨基酸至约200个氨基酸、约100个氨基酸至约190个氨基酸、约100个氨基酸至约180个氨基酸、约100个氨基酸至约170个氨基酸、约100个氨基酸至约160个氨基酸、约100个氨基酸至约150个氨基酸、约100个氨基酸至约140个氨基酸、约100个氨基酸至约130个氨基酸、约100个氨基酸至约120个氨基酸、约100个氨基酸至约110个氨基酸、约120个氨基酸至约800个氨基酸、约120个氨基酸至约790个氨基酸、约120个氨基酸至约780个氨基酸、约120个氨基酸至约770个氨基酸、约120个氨基酸至约760个氨基酸、约120个氨基酸至约750个氨基酸、约120个氨基酸至约740个氨基酸、约120个氨基酸至约730个氨基酸、约120个氨基酸至约720个氨基酸、约120个氨基酸至约710个氨基酸、约120个氨基酸至约700个氨基酸、约120个氨基酸至约690个氨基酸、约120个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约120个氨基酸至约660个氨基酸、约120个氨基酸至约650个氨基酸、约120个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约120个氨基酸至约620个氨基酸、约120个氨基酸至约610个氨基酸、约120个氨基酸至约600个氨基酸、约120个氨基酸至约590个氨基酸、约120个氨基酸至约580个氨基酸、约120个氨基酸至约570个氨基酸、约120个氨基酸至约560个氨基酸、约120个氨基酸至约550个氨基酸、约120个氨基酸至约540个氨基酸、约120个氨基酸至约530个氨基酸、约120个氨基酸至约520个氨基酸、约120个氨基酸至约510个氨基酸、约120个氨基酸至约500个氨基酸、约120个氨基酸至约490个氨基酸、约120个氨基酸至约480个氨基酸、约120个氨基酸至约470个氨基酸、约120个氨基酸至约460个氨基酸、约120个氨基酸至约450个氨基酸、约120个氨基酸至约440个氨基酸、约120个氨基酸至约430个氨基酸、约120个氨基酸至约420个氨基酸、约120个氨基酸至约410个氨基酸、约120个氨基酸至约400个氨基酸、约120个氨基酸至约390个氨基酸、约120个氨基酸至约380个氨基酸、约120个氨基酸至约370个氨基酸、约120个氨基酸至约360个氨基酸、约120个氨基酸至约350个氨基酸、约120个氨基酸至约340个氨基酸、约120个氨基酸至约330个氨基酸、约120个氨基酸至约320个氨基酸、约120个氨基酸至约310个氨基酸、约120个氨基酸至约300个氨基酸、约120个氨基酸至约290个氨基酸、约120个氨基酸至约280个氨基酸、约120个氨基酸至约270个氨基酸、约120个氨基酸至约260个氨基酸、约120个氨基酸至约250个氨基酸、约120个氨基酸至约240个氨基酸、约120个氨基酸至约230个氨基酸、约120个氨基酸至约220个氨基酸、约120个氨基酸至约210个氨基酸、约120个氨基酸至约200个氨基酸、约120个氨基酸至约190个氨基酸、约120个氨基酸至约180个氨基酸、约120个氨基酸至约170个氨基酸、约120个氨基酸至约160个氨基酸、约120个氨基酸至约150个氨基酸、约120个氨基酸至约140个氨基酸、约120个氨基酸至约130个氨基酸、约150个氨基酸至约800个氨基酸、约150个氨基酸至约790个氨基酸、约150个氨基酸至约780个氨基酸、约150个氨基酸至约770个氨基酸、约150个氨基酸至约760个氨基酸、约150个氨基酸至约750个氨基酸、约150个氨基酸至约740个氨基酸、约150个氨基酸至约730个氨基酸、约150个氨基酸至约720个氨基酸、约150个氨基酸至约710个氨基酸、约150个氨基酸至约700个氨基酸、约150个氨基酸至约690个氨基酸、约150个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约150个氨基酸至约660个氨基酸、约150个氨基酸至约650个氨基酸、约150个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约150个氨基酸至约620个氨基酸、约150个氨基酸至约610个氨基酸、约150个氨基酸至约600个氨基酸、约150个氨基酸至约590个氨基酸、约150个氨基酸至约580个氨基酸、约150个氨基酸至约570个氨基酸、约150个氨基酸至约560个氨基酸、约150个氨基酸至约550个氨基酸、约150个氨基酸至约540个氨基酸、约150个氨基酸至约530个氨基酸、约150个氨基酸至约520个氨基酸、约150个氨基酸至约510个氨基酸、约150个氨基酸至约500个氨基酸、约150个氨基酸至约490个氨基酸、约150个氨基酸至约480个氨基酸、约150个氨基酸至约470个氨基酸、约150个氨基酸至约460个氨基酸、约150个氨基酸至约450个氨基酸、约150个氨基酸至约440个氨基酸、约150个氨基酸至约430个氨基酸、约150个氨基酸至约420个氨基酸、约150个氨基酸至约410个氨基酸、约150个氨基酸至约400个氨基酸、约150个氨基酸至约390个氨基酸、约150个氨基酸至约380个氨基酸、约150个氨基酸至约370个氨基酸、约150个氨基酸至约360个氨基酸、约150个氨基酸至约350个氨基酸、约150个氨基酸至约340个氨基酸、约150个氨基酸至约330个氨基酸、约150个氨基酸至约320个氨基酸、约150个氨基酸至约310个氨基酸、约150个氨基酸至约300个氨基酸、约150个氨基酸至约290个氨基酸、约150个氨基酸至约280个氨基酸、约150个氨基酸至约270个氨基酸、约150个氨基酸至约260个氨基酸、约150个氨基酸至约250个氨基酸、约150个氨基酸至约240个氨基酸、约150个氨基酸至约230个氨基酸、约150个氨基酸至约220个氨基酸、约150个氨基酸至约210个氨基酸、约150个氨基酸至约200个氨基酸、约150个氨基酸至约190个氨基酸、约150个氨基酸至约180个氨基酸、约150个氨基酸至约170个氨基酸、约150个氨基酸至约160个氨基酸、约180个氨基酸至约800个氨基酸、约180个氨基酸至约790个氨基酸、约180个氨基酸至约780个氨基酸、约180个氨基酸至约770个氨基酸、约180个氨基酸至约760个氨基酸、约180个氨基酸至约750个氨基酸、约180个氨基酸至约740个氨基酸、约180个氨基酸至约730个氨基酸、约180个氨基酸至约720个氨基酸、约180个氨基酸至约710个氨基酸、约180个氨基酸至约700个氨基酸、约180个氨基酸至约690个氨基酸、约180个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约180个氨基酸至约660个氨基酸、约180个氨基酸至约650个氨基酸、约180个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约180个氨基酸至约620个氨基酸、约180个氨基酸至约610个氨基酸、约180个氨基酸至约600个氨基酸、约180个氨基酸至约590个氨基酸、约180个氨基酸至约580个氨基酸、约180个氨基酸至约570个氨基酸、约180个氨基酸至约560个氨基酸、约180个氨基酸至约550个氨基酸、约180个氨基酸至约540个氨基酸、约180个氨基酸至约530个氨基酸、约180个氨基酸至约520个氨基酸、约180个氨基酸至约510个氨基酸、约180个氨基酸至约500个氨基酸、约180个氨基酸至约490个氨基酸、约180个氨基酸至约480个氨基酸、约180个氨基酸至约470个氨基酸、约180个氨基酸至约460个氨基酸、约180个氨基酸至约450个氨基酸、约180个氨基酸至约440个氨基酸、约180个氨基酸至约430个氨基酸、约180个氨基酸至约420个氨基酸、约180个氨基酸至约410个氨基酸、约180个氨基酸至约400个氨基酸、约180个氨基酸至约390个氨基酸、约180个氨基酸至约380个氨基酸、约180个氨基酸至约370个氨基酸、约180个氨基酸至约360个氨基酸、约180个氨基酸至约350个氨基酸、约180个氨基酸至约340个氨基酸、约180个氨基酸至约330个氨基酸、约180个氨基酸至约320个氨基酸、约180个氨基酸至约310个氨基酸、约180个氨基酸至约300个氨基酸、约180个氨基酸至约290个氨基酸、约180个氨基酸至约280个氨基酸、约180个氨基酸至约270个氨基酸、约180个氨基酸至约260个氨基酸、约180个氨基酸至约250个氨基酸、约180个氨基酸至约240个氨基酸、约180个氨基酸至约230个氨基酸、约180个氨基酸至约220个氨基酸、约180个氨基酸至约210个氨基酸、约180个氨基酸至约200个氨基酸、约180个氨基酸至约190个氨基酸、约200个氨基酸至约800个氨基酸、约200个氨基酸至约790个氨基酸、约200个氨基酸至约780个氨基酸、约200个氨基酸至约770个氨基酸、约200个氨基酸至约760个氨基酸、约200个氨基酸至约750个氨基酸、约200个氨基酸至约740个氨基酸、约200个氨基酸至约730个氨基酸、约200个氨基酸至约720个氨基酸、约200个氨基酸至约710个氨基酸、约200个氨基酸至约700个氨基酸、约200个氨基酸至约690个氨基酸、约200个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约200个氨基酸至约660个氨基酸、约200个氨基酸至约650个氨基酸、约200个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约200个氨基酸至约620个氨基酸、约200个氨基酸至约610个氨基酸、约200个氨基酸至约600个氨基酸、约200个氨基酸至约590个氨基酸、约200个氨基酸至约580个氨基酸、约200个氨基酸至约570个氨基酸、约200个氨基酸至约560个氨基酸、约200个氨基酸至约550个氨基酸、约200个氨基酸至约540个氨基酸、约200个氨基酸至约530个氨基酸、约200个氨基酸至约520个氨基酸、约200个氨基酸至约510个氨基酸、约200个氨基酸至约500个氨基酸、约200个氨基酸至约490个氨基酸、约200个氨基酸至约480个氨基酸、约200个氨基酸至约470个氨基酸、约200个氨基酸至约460个氨基酸、约200个氨基酸至约450个氨基酸、约200个氨基酸至约440个氨基酸、约200个氨基酸至约430个氨基酸、约200个氨基酸至约420个氨基酸、约200个氨基酸至约410个氨基酸、约200个氨基酸至约400个氨基酸、约200个氨基酸至约390个氨基酸、约200个氨基酸至约380个氨基酸、约200个氨基酸至约370个氨基酸、约200个氨基酸至约360个氨基酸、约200个氨基酸至约350个氨基酸、约200个氨基酸至约340个氨基酸、约200个氨基酸至约330个氨基酸、约200个氨基酸至约320个氨基酸、约200个氨基酸至约310个氨基酸、约200个氨基酸至约300个氨基酸、约200个氨基酸至约290个氨基酸、约200个氨基酸至约280个氨基酸、约200个氨基酸至约270个氨基酸、约200个氨基酸至约260个氨基酸、约200个氨基酸至约250个氨基酸、约200个氨基酸至约240个氨基酸、约200个氨基酸至约230个氨基酸、约200个氨基酸至约220个氨基酸、约200个氨基酸至约210个氨基酸、约250个氨基酸至约800个氨基酸、约250个氨基酸至约790个氨基酸、约250个氨基酸至约780个氨基酸、约250个氨基酸至约770个氨基酸、约250个氨基酸至约760个氨基酸、约250个氨基酸至约750个氨基酸、约250个氨基酸至约740个氨基酸、约250个氨基酸至约730个氨基酸、约250个氨基酸至约720个氨基酸、约250个氨基酸至约710个氨基酸、约250个氨基酸至约700个氨基酸、约250个氨基酸至约690个氨基酸、约250个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约250个氨基酸至约660个氨基酸、约250个氨基酸至约650个氨基酸、约250个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约250个氨基酸至约620个氨基酸、约250个氨基酸至约610个氨基酸、约250个氨基酸至约600个氨基酸、约250个氨基酸至约590个氨基酸、约250个氨基酸至约580个氨基酸、约250个氨基酸至约570个氨基酸、约250个氨基酸至约560个氨基酸、约250个氨基酸至约550个氨基酸、约250个氨基酸至约540个氨基酸、约250个氨基酸至约530个氨基酸、约250个氨基酸至约520个氨基酸、约250个氨基酸至约510个氨基酸、约250个氨基酸至约500个氨基酸、约250个氨基酸至约490个氨基酸、约250个氨基酸至约480个氨基酸、约250个氨基酸至约470个氨基酸、约250个氨基酸至约460个氨基酸、约250个氨基酸至约450个氨基酸、约250个氨基酸至约440个氨基酸、约250个氨基酸至约430个氨基酸、约250个氨基酸至约420个氨基酸、约250个氨基酸至约410个氨基酸、约250个氨基酸至约400个氨基酸、约250个氨基酸至约390个氨基酸、约250个氨基酸至约380个氨基酸、约250个氨基酸至约370个氨基酸、约250个氨基酸至约360个氨基酸、约250个氨基酸至约350个氨基酸、约250个氨基酸至约340个氨基酸、约250个氨基酸至约330个氨基酸、约250个氨基酸至约320个氨基酸、约250个氨基酸至约310个氨基酸、约250个氨基酸至约300个氨基酸、约250个氨基酸至约290个氨基酸、约250个氨基酸至约280个氨基酸、约250个氨基酸至约270个氨基酸、约250个氨基酸至约260个氨基酸、约280个氨基酸至约800个氨基酸、约280个氨基酸至约790个氨基酸、约280个氨基酸至约780个氨基酸、约280个氨基酸至约770个氨基酸、约280个氨基酸至约760个氨基酸、约280个氨基酸至约750个氨基酸、约280个氨基酸至约740个氨基酸、约280个氨基酸至约730个氨基酸、约280个氨基酸至约720个氨基酸、约280个氨基酸至约710个氨基酸、约280个氨基酸至约700个氨基酸、约280个氨基酸至约690个氨基酸、约280个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约280个氨基酸至约660个氨基酸、约280个氨基酸至约650个氨基酸、约280个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约280个氨基酸至约620个氨基酸、约280个氨基酸至约610个氨基酸、约280个氨基酸至约600个氨基酸、约280个氨基酸至约590个氨基酸、约280个氨基酸至约580个氨基酸、约280个氨基酸至约570个氨基酸、约280个氨基酸至约560个氨基酸、约280个氨基酸至约550个氨基酸、约280个氨基酸至约540个氨基酸、约280个氨基酸至约530个氨基酸、约280个氨基酸至约520个氨基酸、约280个氨基酸至约510个氨基酸、约280个氨基酸至约500个氨基酸、约280个氨基酸至约490个氨基酸、约280个氨基酸至约480个氨基酸、约280个氨基酸至约470个氨基酸、约280个氨基酸至约460个氨基酸、约280个氨基酸至约450个氨基酸、约280个氨基酸至约440个氨基酸、约280个氨基酸至约430个氨基酸、约280个氨基酸至约420个氨基酸、约280个氨基酸至约410个氨基酸、约280个氨基酸至约400个氨基酸、约280个氨基酸至约390个氨基酸、约280个氨基酸至约380个氨基酸、约280个氨基酸至约370个氨基酸、约280个氨基酸至约360个氨基酸、约280个氨基酸至约350个氨基酸、约280个氨基酸至约340个氨基酸、约280个氨基酸至约330个氨基酸、约280个氨基酸至约320个氨基酸、约280个氨基酸至约310个氨基酸、约280个氨基酸至约300个氨基酸、约300个氨基酸至约800个氨基酸、约300个氨基酸至约790个氨基酸、约300个氨基酸至约780个氨基酸、约300个氨基酸至约770个氨基酸、约300个氨基酸至约760个氨基酸、约300个氨基酸至约750个氨基酸、约300个氨基酸至约740个氨基酸、约300个氨基酸至约730个氨基酸、约300个氨基酸至约720个氨基酸、约300个氨基酸至约710个氨基酸、约300个氨基酸至约700个氨基酸、约300个氨基酸至约690个氨基酸、约300个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约300个氨基酸至约660个氨基酸、约300个氨基酸至约650个氨基酸、约300个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约300个氨基酸至约620个氨基酸、约300个氨基酸至约610个氨基酸、约300个氨基酸至约600个氨基酸、约300个氨基酸至约590个氨基酸、约300个氨基酸至约580个氨基酸、约300个氨基酸至约570个氨基酸、约300个氨基酸至约560个氨基酸、约300个氨基酸至约550个氨基酸、约300个氨基酸至约540个氨基酸、约300个氨基酸至约530个氨基酸、约300个氨基酸至约520个氨基酸、约300个氨基酸至约510个氨基酸、约300个氨基酸至约500个氨基酸、约300个氨基酸至约490个氨基酸、约300个氨基酸至约480个氨基酸、约300个氨基酸至约470个氨基酸、约300个氨基酸至约460个氨基酸、约300个氨基酸至约450个氨基酸、约300个氨基酸至约440个氨基酸、约300个氨基酸至约430个氨基酸、约300个氨基酸至约420个氨基酸、约300个氨基酸至约410个氨基酸、约300个氨基酸至约400个氨基酸、约300个氨基酸至约390个氨基酸、约300个氨基酸至约380个氨基酸、约300个氨基酸至约370个氨基酸、约300个氨基酸至约360个氨基酸、约300个氨基酸至约350个氨基酸、约300个氨基酸至约340个氨基酸、约300个氨基酸至约330个氨基酸、约300个氨基酸至约320个氨基酸、约300个氨基酸至约310个氨基酸、约350个氨基酸至约800个氨基酸、约350个氨基酸至约790个氨基酸、约350个氨基酸至约780个氨基酸、约350个氨基酸至约770个氨基酸、约350个氨基酸至约760个氨基酸、约350个氨基酸至约750个氨基酸、约350个氨基酸至约740个氨基酸、约350个氨基酸至约730个氨基酸、约350个氨基酸至约720个氨基酸、约350个氨基酸至约710个氨基酸、约350个氨基酸至约700个氨基酸、约350个氨基酸至约690个氨基酸、约350个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约350个氨基酸至约660个氨基酸、约350个氨基酸至约650个氨基酸、约350个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约350个氨基酸至约620个氨基酸、约350个氨基酸至约610个氨基酸、约350个氨基酸至约600个氨基酸、约350个氨基酸至约590个氨基酸、约350个氨基酸至约580个氨基酸、约350个氨基酸至约570个氨基酸、约350个氨基酸至约560个氨基酸、约350个氨基酸至约550个氨基酸、约350个氨基酸至约540个氨基酸、约350个氨基酸至约530个氨基酸、约350个氨基酸至约520个氨基酸、约350个氨基酸至约510个氨基酸、约350个氨基酸至约500个氨基酸、约350个氨基酸至约490个氨基酸、约350个氨基酸至约480个氨基酸、约350个氨基酸至约470个氨基酸、约350个氨基酸至约460个氨基酸、约350个氨基酸至约450个氨基酸、约350个氨基酸至约440个氨基酸、约350个氨基酸至约430个氨基酸、约350个氨基酸至约420个氨基酸、约350个氨基酸至约410个氨基酸、约350个氨基酸至约400个氨基酸、约350个氨基酸至约390个氨基酸、约350个氨基酸至约380个氨基酸、约350个氨基酸至约370个氨基酸、约350个氨基酸至约360个氨基酸、约380个氨基酸至约800个氨基酸、约380个氨基酸至约790个氨基酸、约380个氨基酸至约780个氨基酸、约380个氨基酸至约770个氨基酸、约380个氨基酸至约760个氨基酸、约380个氨基酸至约750个氨基酸、约380个氨基酸至约740个氨基酸、约380个氨基酸至约730个氨基酸、约380个氨基酸至约720个氨基酸、约380个氨基酸至约710个氨基酸、约380个氨基酸至约700个氨基酸、约380个氨基酸至约690个氨基酸、约380个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约380个氨基酸至约660个氨基酸、约380个氨基酸至约650个氨基酸、约380个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约380个氨基酸至约620个氨基酸、约380个氨基酸至约610个氨基酸、约380个氨基酸至约600个氨基酸、约380个氨基酸至约590个氨基酸、约380个氨基酸至约580个氨基酸、约380个氨基酸至约570个氨基酸、约380个氨基酸至约560个氨基酸、约380个氨基酸至约550个氨基酸、约380个氨基酸至约540个氨基酸、约380个氨基酸至约530个氨基酸、约380个氨基酸至约520个氨基酸、约380个氨基酸至约510个氨基酸、约380个氨基酸至约500个氨基酸、约380个氨基酸至约490个氨基酸、约380个氨基酸至约480个氨基酸、约380个氨基酸至约470个氨基酸、约380个氨基酸至约460个氨基酸、约380个氨基酸至约450个氨基酸、约380个氨基酸至约440个氨基酸、约380个氨基酸至约430个氨基酸、约380个氨基酸至约420个氨基酸、约380个氨基酸至约410个氨基酸、约380个氨基酸至约400个氨基酸、约380个氨基酸至约390个氨基酸、约400个氨基酸至约800个氨基酸、约400个氨基酸至约790个氨基酸、约400个氨基酸至约780个氨基酸、约400个氨基酸至约770个氨基酸、约400个氨基酸至约760个氨基酸、约400个氨基酸至约750个氨基酸、约400个氨基酸至约740个氨基酸、约400个氨基酸至约730个氨基酸、约400个氨基酸至约720个氨基酸、约400个氨基酸至约710个氨基酸、约400个氨基酸至约700个氨基酸、约400个氨基酸至约690个氨基酸、约400个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约400个氨基酸至约660个氨基酸、约400个氨基酸至约650个氨基酸、约400个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约400个氨基酸至约620个氨基酸、约400个氨基酸至约610个氨基酸、约400个氨基酸至约600个氨基酸、约400个氨基酸至约590个氨基酸、约400个氨基酸至约580个氨基酸、约400个氨基酸至约570个氨基酸、约400个氨基酸至约560个氨基酸、约400个氨基酸至约550个氨基酸、约400个氨基酸至约540个氨基酸、约400个氨基酸至约530个氨基酸、约400个氨基酸至约520个氨基酸、约400个氨基酸至约510个氨基酸、约400个氨基酸至约500个氨基酸、约400个氨基酸至约490个氨基酸、约400个氨基酸至约480个氨基酸、约400个氨基酸至约470个氨基酸、约400个氨基酸至约460个氨基酸、约400个氨基酸至约450个氨基酸、约400个氨基酸至约440个氨基酸、约400个氨基酸至约430个氨基酸、约400个氨基酸至约420个氨基酸、约400个氨基酸至约410个氨基酸、约450个氨基酸至约800个氨基酸、约450个氨基酸至约790个氨基酸、约450个氨基酸至约780个氨基酸、约450个氨基酸至约770个氨基酸、约450个氨基酸至约760个氨基酸、约450个氨基酸至约750个氨基酸、约450个氨基酸至约740个氨基酸、约450个氨基酸至约730个氨基酸、约450个氨基酸至约720个氨基酸、约450个氨基酸至约710个氨基酸、约450个氨基酸至约700个氨基酸、约450个氨基酸至约690个氨基酸、约450个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约450个氨基酸至约660个氨基酸、约450个氨基酸至约650个氨基酸、约450个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约450个氨基酸至约620个氨基酸、约450个氨基酸至约610个氨基酸、约450个氨基酸至约600个氨基酸、约450个氨基酸至约590个氨基酸、约450个氨基酸至约580个氨基酸、约450个氨基酸至约570个氨基酸、约450个氨基酸至约560个氨基酸、约450个氨基酸至约550个氨基酸、约450个氨基酸至约540个氨基酸、约450个氨基酸至约530个氨基酸、约450个氨基酸至约520个氨基酸、约450个氨基酸至约510个氨基酸、约450个氨基酸至约500个氨基酸、约450个氨基酸至约490个氨基酸、约450个氨基酸至约480个氨基酸、约450个氨基酸至约470个氨基酸、约450个氨基酸至约460个氨基酸、约480个氨基酸至约800个氨基酸、约480个氨基酸至约790个氨基酸、约480个氨基酸至约780个氨基酸、约480个氨基酸至约770个氨基酸、约480个氨基酸至约760个氨基酸、约480个氨基酸至约750个氨基酸、约480个氨基酸至约740个氨基酸、约480个氨基酸至约730个氨基酸、约480个氨基酸至约720个氨基酸、约480个氨基酸至约710个氨基酸、约480个氨基酸至约700个氨基酸、约480个氨基酸至约690个氨基酸、约480个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约480个氨基酸至约660个氨基酸、约480个氨基酸至约650个氨基酸、约480个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约480个氨基酸至约620个氨基酸、约480个氨基酸至约610个氨基酸、约480个氨基酸至约600个氨基酸、约480个氨基酸至约590个氨基酸、约480个氨基酸至约580个氨基酸、约480个氨基酸至约570个氨基酸、约480个氨基酸至约560个氨基酸、约480个氨基酸至约550个氨基酸、约480个氨基酸至约540个氨基酸、约480个氨基酸至约530个氨基酸、约480个氨基酸至约520个氨基酸、约480个氨基酸至约510个氨基酸、约480个氨基酸至约500个氨基酸、约480个氨基酸至约490个氨基酸、约50个氨基酸至约800个氨基酸、约50个氨基酸至约790个氨基酸、约50个氨基酸至约780个氨基酸、约50个氨基酸至约770个氨基酸、约50个氨基酸至约760个氨基酸、约50个氨基酸至约750个氨基酸、约50个氨基酸至约740个氨基酸、约50个氨基酸至约730个氨基酸、约50个氨基酸至约720个氨基酸、约50个氨基酸至约710个氨基酸、约50个氨基酸至约700个氨基酸、约50个氨基酸至约690个氨基酸、约50个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约50个氨基酸至约660个氨基酸、约50个氨基酸至约650个氨基酸、约50个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约50个氨基酸至约620个氨基酸、约50个氨基酸至约610个氨基酸、约50个氨基酸至约600个氨基酸、约50个氨基酸至约590个氨基酸、约50个氨基酸至约580个氨基酸、约50个氨基酸至约570个氨基酸、约50个氨基酸至约560个氨基酸、约50个氨基酸至约550个氨基酸、约50个氨基酸至约540个氨基酸、约50个氨基酸至约530个氨基酸、约50个氨基酸至约520个氨基酸、约50个氨基酸至约510个氨基酸、约550个氨基酸至约800个氨基酸、约550个氨基酸至约790个氨基酸、约550个氨基酸至约780个氨基酸、约550个氨基酸至约770个氨基酸、约550个氨基酸至约760个氨基酸、约550个氨基酸至约750个氨基酸、约550个氨基酸至约740个氨基酸、约550个氨基酸至约730个氨基酸、约550个氨基酸至约720个氨基酸、约550个氨基酸至约710个氨基酸、约550个氨基酸至约700个氨基酸、约550个氨基酸至约690个氨基酸、约550个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约550个氨基酸至约660个氨基酸、约550个氨基酸至约650个氨基酸、约550个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约550个氨基酸至约620个氨基酸、约550个氨基酸至约610个氨基酸、约550个氨基酸至约600个氨基酸、约550个氨基酸至约590个氨基酸、约550个氨基酸至约580个氨基酸、约550个氨基酸至约570个氨基酸、约550个氨基酸至约560个氨基酸、约580个氨基酸至约800个氨基酸、约580个氨基酸至约790个氨基酸、约580个氨基酸至约780个氨基酸、约580个氨基酸至约770个氨基酸、约580个氨基酸至约760个氨基酸、约580个氨基酸至约750个氨基酸、约580个氨基酸至约740个氨基酸、约580个氨基酸至约730个氨基酸、约580个氨基酸至约720个氨基酸、约580个氨基酸至约710个氨基酸、约580个氨基酸至约700个氨基酸、约580个氨基酸至约690个氨基酸、约580个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约580个氨基酸至约660个氨基酸、约580个氨基酸至约650个氨基酸、约580个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约580个氨基酸至约620个氨基酸、约580个氨基酸至约610个氨基酸、约580个氨基酸至约600个氨基酸、约580个氨基酸至约590个氨基酸、约600个氨基酸至约800个氨基酸、约600个氨基酸至约790个氨基酸、约600个氨基酸至约780个氨基酸、约600个氨基酸至约770个氨基酸、约600个氨基酸至约760个氨基酸、约600个氨基酸至约750个氨基酸、约600个氨基酸至约740个氨基酸、约600个氨基酸至约730个氨基酸、约600个氨基酸至约720个氨基酸、约600个氨基酸至约710个氨基酸、约600个氨基酸至约700个氨基酸、约600个氨基酸至约690个氨基酸、约600个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约600个氨基酸至约660个氨基酸、约600个氨基酸至约650个氨基酸、约600个氨基酸至约640个氨基酸、约30个氨基酸至约630个氨基酸、约600个氨基酸至约620个氨基酸、约600个氨基酸至约610个氨基酸、约650个氨基酸至约800个氨基酸、约650个氨基酸至约790个氨基酸、约650个氨基酸至约780个氨基酸、约650个氨基酸至约770个氨基酸、约650个氨基酸至约760个氨基酸、约650个氨基酸至约750个氨基酸、约650个氨基酸至约740个氨基酸、约650个氨基酸至约730个氨基酸、约650个氨基酸至约720个氨基酸、约650个氨基酸至约710个氨基酸、约650个氨基酸至约700个氨基酸、约650个氨基酸至约690个氨基酸、约650个氨基酸至约680个氨基酸、30个氨基酸至约670个氨基酸、约650个氨基酸至约660个氨基酸、约680个氨基酸至约800个氨基酸、约680个氨基酸至约790个氨基酸、约680个氨基酸至约780个氨基酸、约680个氨基酸至约770个氨基酸、约680个氨基酸至约760个氨基酸、约680个氨基酸至约750个氨基酸、约680个氨基酸至约740个氨基酸、约680个氨基酸至约730个氨基酸、约680个氨基酸至约720个氨基酸、约680个氨基酸至约710个氨基酸、约680个氨基酸至约700个氨基酸、约680个氨基酸至约690个氨基酸、约700个氨基酸至约800个氨基酸、约700个氨基酸至约790个氨基酸、约700个氨基酸至约780个氨基酸、约700个氨基酸至约770个氨基酸、约700个氨基酸至约760个氨基酸、约700个氨基酸至约750个氨基酸、约700个氨基酸至约740个氨基酸、约700个氨基酸至约730个氨基酸、约700个氨基酸至约720个氨基酸、约700个氨基酸至约710个氨基酸、约750个氨基酸至约800个氨基酸、约750个氨基酸至约790个氨基酸、约750个氨基酸至约780个氨基酸、约750个氨基酸至约770个氨基酸、约750个氨基酸至约760个氨基酸、或约780个氨基酸至约800个氨基酸)。在一些实例中，第二载体还包含poly(A)序列。
在其中组合物中不同载体的数目为2的一些实例中，由所述两种载体之一编码的N末端部分可包括这样的部分，所述部分包含野生型毛细胞靶蛋白(例如，SEQ ID NO:8、SEQID NO:9、SEQ ID NO:10、SEQ ID NO:11、SEQ ID NO:12、SEQ ID NO:20、SEQ ID NO:23、SEQID NO:24、SEQ ID NO:25、SEQ ID NO:26、SEQ ID NO:27、SEQ ID NO:28、SEQ ID NO:30、SEQID NO:31、SEQ ID NO:32、SEQ ID NO:34、SEQ ID NO:39、SEQ ID NO:41、SEQ ID NO:43、SEQID NO:45、SEQ ID NO:48、SEQ ID NO:51、SEQ ID NO:53、SEQ ID NO:55、SEQ ID NO:57、SEQID NO:59、SEQ ID NO:61、SEQ ID NO:64、SEQ ID NO:66、SEQ ID NO:68、SEQ ID NO:69、SEQID NO:70、SEQ ID NO:72、SEQ ID NO:74、SEQ ID NO:76、SEQ ID NO:77、SEQ ID NO:78或SEQ ID NO:79)的氨基酸位置1至约氨基酸位置800、约氨基酸位置790、约氨基酸位置780、约氨基酸位置770、约氨基酸位置760、约氨基酸位置750、约氨基酸位置740、约氨基酸位置730、约氨基酸位置720、约氨基酸位置710、约氨基酸位置700、约氨基酸位置690、约氨基酸位置680、约氨基酸位置670、约氨基酸位置660、约氨基酸位置650、约氨基酸位置640、约氨基酸位置630、约氨基酸位置620、约氨基酸位置610、约氨基酸位置600、约氨基酸位置590、约氨基酸位置580、约氨基酸位置570、约氨基酸位置560、约氨基酸位置550、约氨基酸位置540、约氨基酸位置530、约氨基酸位置520、约氨基酸位置510、约氨基酸位置500、约氨基酸位置490、约氨基酸位置480、约氨基酸位置470、约氨基酸位置460、约氨基酸位置450、约氨基酸位置440、约氨基酸位置430、约氨基酸位置420、约氨基酸位置410、约氨基酸位置400、约氨基酸位置390、约氨基酸位置380、约氨基酸位置370、约氨基酸位置360、约氨基酸位置350、约氨基酸位置340、约氨基酸位置330、约氨基酸位置320、约氨基酸位置310、约氨基酸位置300、约氨基酸位置290、约氨基酸位置280、约氨基酸位置270、约氨基酸位置260、约氨基酸位置250、约氨基酸位置240、约氨基酸位置230、约氨基酸位置220、约氨基酸位置210、约氨基酸位置200、约氨基酸位置190、约氨基酸位置180、约氨基酸位置170、约氨基酸位置160、约氨基酸位置150、约氨基酸位置140、约氨基酸位置130、约氨基酸位置120、约氨基酸位置110、约氨基酸位置100、约氨基酸位置90、约氨基酸位置80、约氨基酸位置70、约氨基酸位置60、约氨基酸位置50或约氨基酸位置40。
在其中组合物中不同载体的数目为2的一些实例中，前体毛细胞靶蛋白的N末端部分可包括这样的部分，所述部分包含野生型毛细胞靶蛋白(例如，SEQ ID NO:8、SEQ IDNO:9、SEQ ID NO:10、SEQ ID NO:11、SEQ ID NO:12、SEQ ID NO:20、SEQ ID NO:23、SEQ IDNO:24、SEQ ID NO:25、SEQ ID NO:26、SEQ ID NO:27、SEQ ID NO:28、SEQ ID NO:30、SEQ IDNO:31、SEQ ID NO:32、SEQ ID NO:34、SEQ ID NO:35、SEQ ID NO:41、SEQ ID NO:43、SEQ IDNO:45、SEQ ID NO:48、SEQ ID NO:51、SEQ ID NO:53、SEQ ID NO:55、SEQ ID NO:57、SEQ IDNO:59、SEQ ID NO:61、SEQ ID NO:64、SEQ ID NO:66、SEQ ID NO:68、SEQ ID NO:69、SEQ IDNO:70、SEQ ID NO:72、SEQ ID NO:74、SEQ ID NO:76、SEQ ID NO:77、SEQ ID NO:78、SEQ IDNO:79)的氨基酸位置1至氨基酸位置300、氨基酸位置1至氨基酸位置310、氨基酸位置1至约氨基酸位置320、氨基酸位置1至约氨基酸位置330、氨基酸位置1至约氨基酸位置340、氨基酸位置1至约氨基酸位置350、氨基酸位置1至约氨基酸位置360、氨基酸位置1至约氨基酸位置370、氨基酸位置1至约氨基酸位置380、氨基酸位置1至约氨基酸位置390、氨基酸位置1至约氨基酸位置400、氨基酸位置1至约氨基酸位置410、氨基酸位置1至约氨基酸位置420、氨基酸位置1至约氨基酸位置430、氨基酸位置1至约氨基酸位置440、氨基酸位置1至约氨基酸位置450、氨基酸位置1至约氨基酸位置460、氨基酸位置1至约氨基酸位置470、氨基酸位置1至约氨基酸位置480、氨基酸位置1至约氨基酸位置490、氨基酸位置1至约氨基酸位置500、氨基酸位置1至约氨基酸位置510、氨基酸位置1至约氨基酸位置520、氨基酸位置1至约氨基酸位置530、氨基酸位置1至约氨基酸位置540、氨基酸位置1至约氨基酸位置550、氨基酸位置1至约氨基酸位置560、氨基酸位置1至约氨基酸位置570、氨基酸位置1至约氨基酸位置580、氨基酸位置1至约氨基酸位置590、氨基酸位置1至约氨基酸位置600、氨基酸位置1至约氨基酸位置610、氨基酸位置1至约氨基酸位置620、氨基酸位置1至约氨基酸位置630、氨基酸位置1至约氨基酸位置640、氨基酸位置1至约氨基酸位置650、氨基酸位置1至约氨基酸位置660、氨基酸位置1至约氨基酸位置670、氨基酸位置1至约氨基酸位置680、氨基酸位置1至约氨基酸位置690、氨基酸位置1至约氨基酸位置700、氨基酸位置1至约氨基酸位置710、氨基酸位置1至约氨基酸位置720、氨基酸位置1至约氨基酸位置730、氨基酸位置1至约氨基酸位置740、氨基酸位置1至约氨基酸位置750、氨基酸位置1至约氨基酸位置760、氨基酸位置1至约氨基酸位置770、氨基酸位置1至约氨基酸位置780、氨基酸位置1至约氨基酸位置790、氨基酸位置1至约氨基酸位置800。
在其中组合物中不同载体的数目为2的一些实例中，由所述两种载体之一编码的N末端部分可包括这样的部分，所述部分包含野生型支持细胞靶蛋白(例如，SEQ ID NO:1或SEQ ID NO:4)的氨基酸位置1至约氨基酸位置800、约氨基酸位置790、约氨基酸位置780、约氨基酸位置770、约氨基酸位置760、约氨基酸位置750、约氨基酸位置740、约氨基酸位置730、约氨基酸位置720、约氨基酸位置710、约氨基酸位置700、约氨基酸位置690、约氨基酸位置680、约氨基酸位置670、约氨基酸位置660、约氨基酸位置650、约氨基酸位置640、约氨基酸位置630、约氨基酸位置620、约氨基酸位置610、约氨基酸位置600、约氨基酸位置590、约氨基酸位置580、约氨基酸位置570、约氨基酸位置560、约氨基酸位置550、约氨基酸位置540、约氨基酸位置530、约氨基酸位置520、约氨基酸位置510、约氨基酸位置500、约氨基酸位置490、约氨基酸位置480、约氨基酸位置470、约氨基酸位置460、约氨基酸位置450、约氨基酸位置440、约氨基酸位置430、约氨基酸位置420、约氨基酸位置410、约氨基酸位置400、约氨基酸位置390、约氨基酸位置380、约氨基酸位置370、约氨基酸位置360、约氨基酸位置350、约氨基酸位置340、约氨基酸位置330、约氨基酸位置320、约氨基酸位置310、约氨基酸位置300、约氨基酸位置290、约氨基酸位置280、约氨基酸位置270、约氨基酸位置260、约氨基酸位置250、约氨基酸位置240、约氨基酸位置230、约氨基酸位置220、约氨基酸位置210、约氨基酸位置200、约氨基酸位置190、约氨基酸位置180、约氨基酸位置170、约氨基酸位置160、约氨基酸位置150、约氨基酸位置140、约氨基酸位置130、约氨基酸位置120、约氨基酸位置110、约氨基酸位置100、约氨基酸位置90、约氨基酸位置80、约氨基酸位置70、约氨基酸位置60、约氨基酸位置50或约氨基酸位置40。
在其中组合物中不同载体的数目为2的一些实例中，前体支持细胞靶蛋白的N末端部分包括这样的部分，所述部分包含野生型支持细胞靶蛋白(例如，SEQ ID NO:1或SEQID NO:4)的氨基酸位置1至氨基酸位置300、氨基酸位置1至氨基酸位置310、氨基酸位置1至约氨基酸位置320、氨基酸位置1至约氨基酸位置330、氨基酸位置1至约氨基酸位置340、氨基酸位置1至约氨基酸位置350、氨基酸位置1至约氨基酸位置360、氨基酸位置1至约氨基酸位置370、氨基酸位置1至约氨基酸位置380、氨基酸位置1至约氨基酸位置390、氨基酸位置1至约氨基酸位置400、氨基酸位置1至约氨基酸位置410、氨基酸位置1至约氨基酸位置420、氨基酸位置1至约氨基酸位置430、氨基酸位置1至约氨基酸位置440、氨基酸位置1至约氨基酸位置450、氨基酸位置1至约氨基酸位置460、氨基酸位置1至约氨基酸位置470、氨基酸位置1至约氨基酸位置480、氨基酸位置1至约氨基酸位置490、氨基酸位置1至约氨基酸位置500、氨基酸位置1至约氨基酸位置510、氨基酸位置1至约氨基酸位置520、氨基酸位置1至约氨基酸位置530、氨基酸位置1至约氨基酸位置540、氨基酸位置1至约氨基酸位置550、氨基酸位置1至约氨基酸位置560、氨基酸位置1至约氨基酸位置570、氨基酸位置1至约氨基酸位置580、氨基酸位置1至约氨基酸位置590、氨基酸位置1至约氨基酸位置600、氨基酸位置1至约氨基酸位置610、氨基酸位置1至约氨基酸位置620、氨基酸位置1至约氨基酸位置630、氨基酸位置1至约氨基酸位置640、氨基酸位置1至约氨基酸位置650、氨基酸位置1至约氨基酸位置660、氨基酸位置1至约氨基酸位置670、氨基酸位置1至约氨基酸位置680、氨基酸位置1至约氨基酸位置690、氨基酸位置1至约氨基酸位置700、氨基酸位置1至约氨基酸位置710、氨基酸位置1至约氨基酸位置720、氨基酸位置1至约氨基酸位置730、氨基酸位置1至约氨基酸位置740、氨基酸位置1至约氨基酸位置750、氨基酸位置1至约氨基酸位置760、氨基酸位置1至约氨基酸位置770、氨基酸位置1至约氨基酸位置780、氨基酸位置1至约氨基酸位置790、氨基酸位置1至约氨基酸位置800。
如本文所用，术语“载体”意指包括能够携带至少一个外源核酸片段的多核苷酸在内的组合物，例如质粒载体、转座子、粘粒、人工染色体(例如，人的人工染色体(HAC)、酵母人工染色体(YAC)、细菌人工染色体(BAC)或P1衍生的人工染色体(PAC))或病毒载体(例如，任何腺病毒载体(例如，pSV或pCMV载体)，如本文所述的任何逆转录病毒载体)和任何
Figure BDA0003112389540005561
载体。载体可以例如包含足够的用于表达的顺式作用元件；用于表达的其它表达元件可以由宿主灵长类动物细胞提供或在体外表达系统中提供。术语“载体”包括当与适当的控制元件结合时能够复制的任何遗传元件(例如，质粒、转座子、粘粒、人工染色体或病毒载体等)。因此，所述术语包括克隆性载体和表达载体，以及病毒载体(例如，腺相关病毒(AAV)载体、腺病毒载体、慢病毒载体或逆转录病毒载体)。
载体包括本领域已知的所有载体，包括并入了重组多核苷酸的粘粒、质粒(例如，裸露的或包含在脂质体中)和病毒(例如，慢病毒、逆转录病毒、腺病毒和腺相关病毒)。技术人员将能够选择合适的载体和灵长类动物细胞来制备本文所述的任何核酸。
在一些实施方案中，载体是质粒(即可以在细胞内部自主复制的环状DNA分子)。在一些实施方案中，载体可以是粘粒(例如，pWE和sCos系列(Wahl等人(1987)，Evans等人(1989))。
在一些实施方案中，一种或多种载体是病毒载体(例如，腺相关病毒、腺病毒、慢病毒和逆转录病毒)。本文描述了病毒载体的非限制性实例。在一些实施方案中，一种或多种载体是腺相关病毒载体(AAV)(参见，例如，Asokan等人，Mol.Ther.20:699-7080,2012)。“重组AAV载体”或“rAAV”通常至少由转基因或其一部分和调控序列、以及任选地5'和3'AAV反向末端重复序列(ITR)组成。这样的重组AAV载体被包装到衣壳中并且被递送到选定的靶细胞(例如，外毛细胞)。
载体的AAV序列通常包含顺式作用的5'和3’ITR序列(参见，例如，B.J.Carter，"Handbook of Parvoviruses"，编辑，P.Tijsser,CRC Press，第155至168页，1990)。典型的AAV ITR序列的长度约为145个核苷酸。在一些实施方案中，将至少75％(例如，至少80％、至少85％、至少90％或至少95％)的典型ITR序列整合到AAV载体中。修饰这些ITR序列的能力在本领域技术人员的能力范围内。(参见，例如，教科书诸如Sambrook等人，"MolecularCloning.A Laboratory Manual"，第2版，Cold Spring Harbor Laboratory,New York,1989；和K.Fisher等人，J Virol.70:520 532,1996)。在一些实施方案中，本文所述的任何编码序列在AAV载体中侧接有5'和3’AAV ITR序列。AAV ITR序列可以从任何已知的AAV，包括目前鉴定的AAV类型中获得。
如本文所述的AAV载体可包括本文所述的任何调控元件(例如，启动子、polyA序列和IRES中的一者或多者)。
在一些实施方案中，AAV载体选自由以下组成的组：AAV1载体、AAV2载体、AAV3载体、AAV4载体、AAV5载体、AAV6载体、AAV7载体、AAV8载体、AAV9载体、AAV2.7m8载体、AAV8BP2载体和AAV293载体。可在本文中使用的其它示例性AAV载体是本领域已知的。参见，例如，Kanaan等人，Mol.Ther.Nucleic Acids 8:184-197,2017；Li等人，Mol.Ther.16(7):1252-1260；Adachi等人，Nat.Commun.5:3075,2014；Isgrig等人，Nat.Commun.10(1):427,2019和Gao等人，J.Virol.78(12):6381-6388。
在一些实施方案中，所述一种或多种载体为腺病毒(参见，例如，Dmitriev等人，(1998)J.Virol.72:9706-9713；和Poulin等人，J.Virol 8:10074-10086,2010)。在一些实施方案中，所述一种或多种载体为逆转录病毒(参见，例如，Maier等人，(2010)FutureMicrobiol 5:1507-23)。
本文提供的载体可具有不同的大小。在本文所述的任何组合物、试剂盒和方法中使用的载体的选择可取决于载体的大小。
在一些实施方案中，所述一种或多种载体是质粒，并且可包括多达约1kb、多达约2kb、多达约3kb、多达约4kb、多达约5kb、多达约6kb、多达约7kb、多达约8kb、多达约9kb、多达约10kb、多达约11kb、多达约12kb、多达约13kb、多达约14kb或多达约15kb的总长度。在一些实施方案中，所述一种或多种载体是质粒，并且可具有在约1kb至约2kb、约1kb至约3kb、约1kb至约4kb、约1kb至约5kb、约1kb至约6kb、约1kb至约7kb、约1kb至约8kb、约1kb至约9kb、约1kb至约10kb、约1kb至约11kb、约1kb至约12kb、约1kb至约13kb、约1kb至约14kb或约1kb至约15kb的范围内的总长度。
在一些实施方案中，所述一种或多种载体是病毒载体并且可具有多达10kb的核苷酸总数。在一些实施方案中，所述一种或多种病毒载体可具有在以下范围内的核苷酸总数：约1kb至约2kb,1kb至约3kb、约1kb至约4kb、约1kb至约5kb、约1kb至约6kb、约1kb至约7kb、约1kb至约8kb、约1kb至约9kb、约1kb至约10kb、约2kb至约3kb、约2kb至约4kb、约2kb至约5kb、约2kb至约6kb、约2kb至约7kb、约2kb至约8kb、约2kb至约9kb、约2kb至约10kb、约3kb至约4kb、约3kb至约5kb、约3kb至约6kb、约3kb至约7kb、约3kb至约8kb、约3kb至约9kb、约3kb至约10kb、约4kb至约5kb、约4kb至约6kb、约4kb至约7kb、约4kb至约8kb、约4kb至约9kb、约4kb至约10kb、约5kb至约6kb、约5kb至约7kb、约5kb至约8kb、约5kb至约9kb、约5kb至约10kb、约6kb至约7kb、约6kb至约8kb、约6kb至约9kb、约6kb至约10kb、约7kb至约8kb、约7kb至约9kb、约7kb至约10kb、约8kb至约9kb、约8kb至约10kb或约9kb至约10kb。
在一些实施方案中，所述一种或多种载体是慢病毒并且可具有多达8kb的核苷酸总数。在一些实施方案中，所述一种或多种病毒载体可具有在以下范围内的核苷酸总数：约1kb至约2kb、约1kb至约3kb、约1kb至约4kb、约1kb至约5kb、约1kb至约6kb、约1kb至约7kb、约1kb至约8kb、约2kb至约3kb、约2kb至约4kb、约2kb至约5kb、约2kb至约6kb、约2kb至约7kb、约2kb至约8kb、约3kb至约4kb、约3kb至约5kb、约3kb至约6kb、约3kb至约7kb、约3kb至约8kb、约4kb至约5kb、约4kb至约6kb、约4kb至约7kb、约4kb至约8kb、约5kb至约6kb、约5kb至约7kb、约5kb至约8kb、约6kb至约8kb、约6kb至约7kb或约7kb至约8kb。
在一些实施方案中，所述一种或多种载体是腺病毒并且可具有多达8kb的核苷酸总数。在一些实施方案中，所述一种或多种腺病毒可具有在以下范围内的核苷酸总数：约1kb至约2kb、约1kb至约3kb、约1kb至约4kb、约1kb至约5kb、约1kb至约6kb、约1kb至约7kb、约1kb至约8kb、约2kb至约3kb、约2kb至约4kb、约2kb至约5kb、约2kb至约6kb、约2kb至约7kb、约2kb至约8kb、约3kb至约4kb、约3kb至约5kb、约3kb至约6kb、约3kb至约7kb、约3kb至约8kb、约4kb至约5kb、约4kb至约6kb、约4kb至约7kb、约4kb至约8kb、约5kb至约6kb、约5kb至约7kb、约5kb至约8kb、约6kb至约7kh、约6kb至约8kb或约7kb至约8kb。
在一些实施方案中，所述一种或多种载体是腺相关病毒(AAV载体)，并且可以包含多达5kb的核苷酸总数。在一些实施方案中，所述一种或多种AAV载体可包含在以下范围内的核苷酸总数：约1kb至约2kb、约1kb至约3kb、约1kb至约4kb、约1kb至约5kb、约2kb至约3kb、约2kb至约4kb、约2kb至约5kb、约3kb至约4kb、约3kb至约5kb或约4kb至约5kb。
在本文提供的任何组合物、试剂盒和方法的一些实施方案中，至少两种不同的载体可以是基本上相同类型的载体并且可以在大小上不同。在一些实施方案中，至少两种不同的载体可以是不同类型的载体，并且可具有基本相同的大小或具有不同的大小。
在一些实施方案中，所述至少两种载体中的任一种可具有在以下范围内的核苷酸总数：约500个核苷酸至约10,000个核苷酸、约500个核苷酸至约9,500个核苷酸、约500个核苷酸至约9,000个核苷酸、约500个核苷酸至约8,500个核苷酸、约500个核苷酸至约8,000个核苷酸、约500个核苷酸至约7,800个核苷酸、约500个核苷酸至约7,600个核苷酸、约500个核苷酸至约7,400个核苷酸、约500个核苷酸至约7,200个核苷酸、约500个核苷酸至约7,000个核苷酸、约500个核苷酸至约6,800个核苷酸、约500个核苷酸至约6,600个核苷酸、约500个核苷酸至约6,400个核苷酸、约500个核苷酸至约6,200个核苷酸、约500个核苷酸至约6,000个核苷酸、约500个核苷酸至约5,800个核苷酸、约500个核苷酸至约5,600个核苷酸、约500个核苷酸至约5,400个核苷酸、约500个核苷酸至约5,200个核苷酸、约500个核苷酸至约5,000个核苷酸、约500个核苷酸至约4,800个核苷酸、约4,600个核苷酸、约500个核苷酸至约4,400个核苷酸、约500个核苷酸至约4,200个核苷酸、约500个核苷酸至约4,000个核苷酸、约500个核苷酸至约3,800个核苷酸、约500个核苷酸至约3,600个核苷酸、约500个核苷酸至约3,400个核苷酸、约500个核苷酸至约3,200个核苷酸、约500个核苷酸至约3,000个核苷酸、约500个核苷酸至约2,800个核苷酸、约500个核苷酸至约2,600个核苷酸、约500个核苷酸至约2,400个核苷酸、约500个核苷酸至约2,200个核苷酸、约500个核苷酸至约2,000个核苷酸、约500个核苷酸至约1,800个核苷酸、约500个核苷酸至约1,600个核苷酸、约500个核苷酸至约1,400个核苷酸、约500个核苷酸至约1,200个核苷酸、约500个核苷酸至约1,000个核苷酸、约500个核苷酸至约800个核苷酸、约800个核苷酸至约10,000个核苷酸、约800个核苷酸至约9,500个核苷酸、约800个核苷酸至约9,000个核苷酸、约800个核苷酸至约8,500个核苷酸、约800个核苷酸至约8,000个核苷酸、约800个核苷酸至约7,800个核苷酸、约800个核苷酸至约7,600个核苷酸、约800个核苷酸至约7,400个核苷酸、约800个核苷酸至约7,200个核苷酸、约800个核苷酸至约7,000个核苷酸、约800个核苷酸至约6,800个核苷酸、约800个核苷酸至约6,600个核苷酸、约800个核苷酸至约6,400个核苷酸、约800个核苷酸至约6,200个核苷酸、约800个核苷酸至约6,000个核苷酸、约800个核苷酸至约5,800个核苷酸、约800个核苷酸至约5,600个核苷酸、约800个核苷酸至约5,400个核苷酸、约800个核苷酸至约5,200个核苷酸、约800个核苷酸至约5,000个核苷酸、约800个核苷酸至约4,800个核苷酸、约800个核苷酸至约4,600个核苷酸、约800个核苷酸至约4,400个核苷酸、约800个核苷酸至约4,200个核苷酸、约800个核苷酸至约4,000个核苷酸、约800个核苷酸至约3,800个核苷酸、约800个核苷酸至约3,600个核苷酸、约800个核苷酸至约3,400个核苷酸、约800个核苷酸至约3,200个核苷酸、约800个核苷酸至约3,000个核苷酸、约800个核苷酸至约2,800个核苷酸、约800个核苷酸至约2,600个核苷酸、约800个核苷酸至约2,400个核苷酸、约800个核苷酸至约2,200个核苷酸、约800个核苷酸至约2,000个核苷酸、约800个核苷酸至约1,800个核苷酸、约800个核苷酸至约1,600个核苷酸、约800个核苷酸至约1,400个核苷酸、约800个核苷酸至约1,200个核苷酸、约800个核苷酸至约1,000个核苷酸、约1,000个核苷酸至约10,000个核苷酸、约1,000个核苷酸至约9,000个核苷酸、约1,000个核苷酸至约8,500个核苷酸、约1,000个核苷酸至约8,000个核苷酸、约1,000个核苷酸至约7,800个核苷酸、约1,000个核苷酸至约7,600个核苷酸、约1,000个核苷酸至约7,400个核苷酸、约1,000个核苷酸至约7,200个核苷酸、约1,000个核苷酸至约7,000个核苷酸、约1,000个核苷酸至约6,800个核苷酸、约1,000个核苷酸至约6,600个核苷酸、约1,000个核苷酸至约6,400个核苷酸、约1,000个核苷酸至约6,200个核苷酸、约1,000个核苷酸至约6,000个核苷酸、约1,000个核苷酸至约5,800个核苷酸、约1,000个核苷酸至约5,600个核苷酸、约1,000个核苷酸至约5,400个核苷酸、约1,000个核苷酸至约5,200个核苷酸、约1,000个核苷酸至约5,000个核苷酸、约1,000个核苷酸至约4,800个核苷酸、约1,000个核苷酸至约4,600个核苷酸、约1,000个核苷酸至约4,400个核苷酸、约1,000个核苷酸至约4,200个核苷酸、约1,000个核苷酸至约4,000个核苷酸、约1,000个核苷酸至约3,800个核苷酸、约1,000个核苷酸至约3,600个核苷酸、约1,000个核苷酸至约3,400个核苷酸、约1,000个核苷酸至约3,200个核苷酸、约1,000个核苷酸至约3,000个核苷酸、约1,000个核苷酸至约2,600个核苷酸、约1,000个核苷酸至约2,400个核苷酸、约1,000个核苷酸至约2,200个核苷酸、约1,000个核苷酸至约2,000个核苷酸、约1,000个核苷酸至约1,800个核苷酸、约1,000个核苷酸至约1,600个核苷酸、约1,000个核苷酸至约1,400个核苷酸、约1,000个核苷酸至约1,200个核苷酸、约1,200个核苷酸至约10,000个核苷酸、约1,200个核苷酸至约9,500个核苷酸、约1,200个核苷酸至约9,000个核苷酸、约1,200个核苷酸至约8,500个核苷酸、约1,200个核苷酸至约8,000个核苷酸、约1,200个核苷酸至约7,800个核苷酸、约1,200个核苷酸至约7,600个核苷酸、约1,200个核苷酸至约7,400个核苷酸、约1,200个核苷酸至约7,200个核苷酸、约1,200个核苷酸至约7,000个核苷酸、约1,200个核苷酸至约6,800个核苷酸、约1,200个核苷酸至约6,600个核苷酸、约1,200个核苷酸至约6,400个核苷酸、约1,200个核苷酸至约6,200个核苷酸、约1,200个核苷酸至约6,000个核苷酸、约1,200个核苷酸至约5,800个核苷酸、约1,200个核苷酸至约5,600个核苷酸、约1,200个核苷酸至约5,400个核苷酸、约1,200个核苷酸至约5,000个核苷酸、约1,200个核苷酸至约4,800个核苷酸、约1,200个核苷酸至约4,600个核苷酸、约1,200个核苷酸至约4,400个核苷酸、约1,200个核苷酸至约4,200个核苷酸、约1,200个核苷酸至约4,000个核苷酸、约1,200个核苷酸至约3,800个核苷酸、约1,200个核苷酸至约3,600个核苷酸、约1,200个核苷酸至约3,400个核苷酸、约1,200个核苷酸至约3,200个核苷酸、约1,200个核苷酸至约3,000个核苷酸、约1,200个核苷酸至约2,800个核苷酸、约1,200个核苷酸至约2,600个核苷酸、约1,200个核苷酸至约2,400个核苷酸、约1,200个核苷酸至约2,200个核苷酸、约1,200个核苷酸至约2,000个核苷酸、约1,200个核苷酸至约1,800个核苷酸、约1,200个核苷酸至约1,600个核苷酸、约1,200个核苷酸至约1,400个核苷酸、约1,400个核苷酸至约10,000个核苷酸、约1,400个核苷酸至约9,500个核苷酸、约1,400个核苷酸至约9,000个核苷酸、约1,400个核苷酸至约8,500个核苷酸、约1,400个核苷酸至约8,000个核苷酸、约1,400个核苷酸至约7,800个核苷酸、约1,400个核苷酸至约7,600个核苷酸、约1,400个核苷酸至约7,400个核苷酸、约1,400个核苷酸至约7,200个核苷酸、约1,400个核苷酸至约7,000个核苷酸、约1,400个核苷酸至约6,800个核苷酸、约1,400个核苷酸至约6,600个核苷酸、约1,400个核苷酸至约6,400个核苷酸、约1,400个核苷酸至约6,200个核苷酸、约1,400个核苷酸至约6,000个核苷酸、约1,400个核苷酸至约5,800个核苷酸、约1,400个核苷酸至约5,600个核苷酸、约1,400个核苷酸至约5,400个核苷酸、约1,400个核苷酸至约5,200个核苷酸、约1,400个核苷酸至约5,000个核苷酸、约1,400个核苷酸至约4,800个核苷酸、约1,400个核苷酸至约4,600个核苷酸、约1,400个核苷酸至约4,400个核苷酸、约1,400个核苷酸至约4,200个核苷酸、约1,400个核苷酸至约4,000个核苷酸、约1,400个核苷酸至约3,800个核苷酸、约1,400个核苷酸至约3,600个核苷酸、约1,400个核苷酸至约3,400个核苷酸、约1,400个核苷酸至约3,200个核苷酸、约1,400个核苷酸至约3,000个核苷酸、约1,400个核苷酸至约2,600个核苷酸、约1,400个核苷酸至约2,400个核苷酸、约1,400个核苷酸至约2,200个核苷酸、约1,400个核苷酸至约2,000个核苷酸、约1,400个核苷酸至约1,800个核苷酸、约1,400个核苷酸至约1,600个核苷酸、约1,600个核苷酸至约10,000个核苷酸、约1,600个核苷酸至约9,500个核苷酸、约1,600个核苷酸至约9,000个核苷酸、约1,600个核苷酸至约8,500个核苷酸、约1,600个核苷酸至约8,000个核苷酸、约1,600个核苷酸至约7,800个核苷酸、约1,600个核苷酸至约7,600个核苷酸、约1,600个核苷酸至约7,400个核苷酸、约1,600个核苷酸至约7,200个核苷酸、约1,600个核苷酸至约7,000个核苷酸、约1,600个核苷酸至约6,800个核苷酸、约1,600个核苷酸至约6,400个核苷酸、约1,600个核苷酸至约6,200个核苷酸、约1,600个核苷酸至约6,000个核苷酸、约1,600个核苷酸至约5,800个核苷酸、约1,600个核苷酸至约5,600个核苷酸、约1,600个核苷酸至约5,400个核苷酸、约1,600个核苷酸至约5,200个核苷酸、约1,600个核苷酸至约5,000个核苷酸、约1,600个核苷酸至约4,800个核苷酸、约1,600个核苷酸至约4,600个核苷酸、约1,600个核苷酸至约4,400个核苷酸、约1,600个核苷酸至约4,200个核苷酸、约1,600个核苷酸至约4,000个核苷酸、约1,600个核苷酸至约3,800个核苷酸、约1,600个核苷酸至约3,600个核苷酸、约1,600个核苷酸至约3,400个核苷酸、约1,600个核苷酸至约3,200个核苷酸、约1,600个核苷酸至约3,000个核苷酸、约1,600个核苷酸至约2,800个核苷酸、约1,600个核苷酸至约2,600个核苷酸、约1,600个核苷酸至约2,400个核苷酸、约1,600个核苷酸至约2,200个核苷酸、约1,600个核苷酸至约2,000个核苷酸、约1,600个核苷酸至约1,800个核苷酸、约1,800个核苷酸至约10,000个核苷酸、约1,800个核苷酸至约9,500个核苷酸、约1,800个核苷酸至约9,000个核苷酸、约1,800个核苷酸至约8,500个核苷酸、约1,800个核苷酸至约8,000个核苷酸、约1,800个核苷酸至约7,800个核苷酸、约1,800个核苷酸至约7,600个核苷酸、约1,800个核苷酸至约7,400个核苷酸、约1,800个核苷酸至约7,200个核苷酸、约1,800个核苷酸至约7,000个核苷酸、约1,800个核苷酸至约6,800个核苷酸、约1,800个核苷酸至约6,600个核苷酸、约1,800个核苷酸至约6,400个核苷酸、约1,800个核苷酸至约6,200个核苷酸、约1,800个核苷酸至约6,000个核苷酸、约1,800个核苷酸至约5,800个核苷酸、约1,800个核苷酸至约5,600个核苷酸、约1,800个核苷酸至约5,400个核苷酸、约1,800个核苷酸至约5,200个核苷酸、约1,800个核苷酸至约5,000个核苷酸、约1,800个核苷酸至约4,800个核苷酸、约1,800个核苷酸至约4,600个核苷酸、约1,800个核苷酸至约4,400个核苷酸、约1,800个核苷酸至约4,200个核苷酸、约1,800个核苷酸至约4,000个核苷酸、约1,800个核苷酸至约3,800个核苷酸、约1,800个核苷酸至约3,600个核苷酸、约1,800个核苷酸至约3,400个核苷酸、约1,800个核苷酸至约3,200个核苷酸、约1,800个核苷酸至约3,000个核苷酸、约1,800个核苷酸至约2,800个核苷酸、约1,800个核苷酸至约2,600个核苷酸、约1,800个核苷酸至约2,400个核苷酸、约1,800个核苷酸至约2,200个核苷酸、约1,800个核苷酸至约2,000个核苷酸、约2,000个核苷酸至约10,000个核苷酸、约2,000个核苷酸至约9,500个核苷酸、约2,000个核苷酸至约9,000个核苷酸、约2,000个核苷酸至约8,500个核苷酸、约2,000个核苷酸至约8,000个核苷酸、约2,000个核苷酸至约7,800个核苷酸、约2,000个核苷酸至约7,600个核苷酸、约2,000个核苷酸至约7,400个核苷酸、约2,000个核苷酸至约7,200个核苷酸、约2,000个核苷酸至约7,000个核苷酸、约2,000个核苷酸至约6,800个核苷酸、约2,000个核苷酸至约6,600个核苷酸、约2,000个核苷酸至约6,400个核苷酸、约2,000个核苷酸至约6,200个核苷酸、约2,000个核苷酸至约6,000个核苷酸、约2,000个核苷酸至约5,800个核苷酸、约2,000个核苷酸至约5,600个核苷酸、约2,000个核苷酸至约5,400个核苷酸、约2,000个核苷酸至约5,200个核苷酸、约2,000个核苷酸至约5,000个核苷酸、约2,000个核苷酸至约4,800个核苷酸、约2,000个核苷酸至约4,600个核苷酸、约2,000个核苷酸至约4,400个核苷酸、约2,000个核苷酸至约4,200个核苷酸、约2,000个核苷酸至约4,000个核苷酸、约2,000个核苷酸至约3,800个核苷酸、约2,000个核苷酸至约3,600个核苷酸、约2,000个核苷酸至约3,400个核苷酸、约2,000个核苷酸至约3,200个核苷酸、约2,000个核苷酸至约3,000个核苷酸、约2,000个核苷酸至约2,800个核苷酸、约2,000个核苷酸至约2,600个核苷酸、约2,000个核苷酸至约2,400个核苷酸、约2,000个核苷酸至约2,200个核苷酸、约2,200个核苷酸至约10,000个核苷酸、约9,500个核苷酸、约9,000个核苷酸、约8,500个核苷酸、约8,000个核苷酸、约7,800个核苷酸、约7,600个核苷酸、约7,400个核苷酸、约7,200个核苷酸、约7,000个核苷酸、约6,800个核苷酸、约6,600个核苷酸、约6,400个核苷酸、约6,200个核苷酸、约6,000个核苷酸、约5,800个核苷酸、约5,600个核苷酸、约5,400个核苷酸、约5,200个核苷酸、约5,000个核苷酸、约4,800个核苷酸、约4,600个核苷酸、约4,400个核苷酸、约4,200个核苷酸、约4,000个核苷酸、约3,800个核苷酸、约3,600个核苷酸、约3,400个核苷酸、约3,200个核苷酸、约3,000个核苷酸、约2,800个核苷酸、约2,600个核苷酸、约2,400个核苷酸、约2,400个核苷酸至约10,000个核苷酸、约2,400个核苷酸至约9,500个核苷酸、约2,400个核苷酸至约9,000个核苷酸、约2,400个核苷酸至约8,500个核苷酸、约2,400个核苷酸至约8,000个核苷酸、约2,400个核苷酸至约7,800个核苷酸、约2,400个核苷酸至约7,600个核苷酸、约2,400个核苷酸至约7,400个核苷酸、约2,400个核苷酸至约7,200个核苷酸、约2,400个核苷酸至约7,000个核苷酸、约2,400个核苷酸至约6,800个核苷酸、约2,400个核苷酸至约6,600个核苷酸、约2,400个核苷酸至约6,400个核苷酸、约2,400个核苷酸至约6,200个核苷酸、约2,400个核苷酸至约6,000个核苷酸、约2,400个核苷酸至约5,800个核苷酸、约2,400个核苷酸至约5,600个核苷酸、约2,400个核苷酸至约5,400个核苷酸、约2,400个核苷酸至约5,200个核苷酸、约2,400个核苷酸至约5,000个核苷酸、约2,400个核苷酸至约4,800个核苷酸、约2,400个核苷酸至约4,600个核苷酸、约2,400个核苷酸至约4,400个核苷酸、约2,400个核苷酸至约4,200个核苷酸、约2,400个核苷酸至约4,000个核苷酸、约2,400个核苷酸至约3,800个核苷酸、约2,400个核苷酸至约3,600个核苷酸、约2,400个核苷酸至约3,400个核苷酸、约2,400个核苷酸至约3,200个核苷酸、约2,400个核苷酸至约3,000个核苷酸、约2,400个核苷酸至约2,800个核苷酸、约2,400个核苷酸至约2,600个核苷酸、约2,600个核苷酸至约10,000个核苷酸、约2,600个核苷酸至约9,500个核苷酸、约2,600个核苷酸至约9,000个核苷酸、约2,600个核苷酸至约8,500个核苷酸、约2,600个核苷酸至约8,000个核苷酸、约2,600个核苷酸至约7,800个核苷酸、约2,600个核苷酸至约7,600个核苷酸、约2,600个核苷酸至约7,400个核苷酸、约2,600个核苷酸至约7,200个核苷酸、约2,600个核苷酸至约7,000个核苷酸、约2,600个核苷酸至约6,800个核苷酸、约2,600个核苷酸至约6,600个核苷酸、约2,600个核苷酸至约6,400个核苷酸、约2,600个核苷酸至约6,200个核苷酸、约2,600个核苷酸至约6,000个核苷酸、约2,600个核苷酸至约5,800个核苷酸、约2,600个核苷酸至约5,600个核苷酸、约2,600个核苷酸至约5,400个核苷酸、约2,600个核苷酸至约5,200个核苷酸、约2,600个核苷酸至约5,000个核苷酸、约2,600个核苷酸至约4,800个核苷酸、约2,600个核苷酸至约4,600个核苷酸、约2,600个核苷酸至约4,400个核苷酸、约2,600个核苷酸至约4,200个核苷酸、约2,600个核苷酸至约4,000个核苷酸、约2,600个核苷酸至约3,800个核苷酸、约2,600个核苷酸至约3,600个核苷酸、约2,600个核苷酸至约3,400个核苷酸、约2,600个核苷酸至约3,200个核苷酸、约2,600个核苷酸至约3,000个核苷酸、约2,600个核苷酸至约2,800个核苷酸、约2,800个核苷酸至约10,000个核苷酸、约2,800个核苷酸至约9,500个核苷酸、约2,800个核苷酸至约9,000个核苷酸、约2,800个核苷酸至约8,500个核苷酸、约2,800个核苷酸至约8,000个核苷酸、约2,800个核苷酸至约7,800个核苷酸、约2,800个核苷酸至约7,600个核苷酸、约2,800个核苷酸至约7,400个核苷酸、约2,800个核苷酸至约7,200个核苷酸、约2,800个核苷酸至约7,000个核苷酸、约2,800个核苷酸至约6,800个核苷酸、约2,800个核苷酸至约6,600个核苷酸、约2,800个核苷酸至约6,400个核苷酸、约2,800个核苷酸至约6,200个核苷酸、约2,800个核苷酸至约6,000个核苷酸、约2,800个核苷酸至约5,800个核苷酸、约2,800个核苷酸至约5,600个核苷酸、约2,800个核苷酸至约5,400个核苷酸、约2,800个核苷酸至约5,200个核苷酸、约2,800个核苷酸至约5,000个核苷酸、约2,800个核苷酸至约4,800个核苷酸、约2,800个核苷酸至约4,600个核苷酸、约2,800个核苷酸至约4,400个核苷酸、约2,800个核苷酸至约4,200个核苷酸、约2,800个核苷酸至约4,000个核苷酸、约2,800个核苷酸至约3,800个核苷酸、约2,800个核苷酸至约3,600个核苷酸、约2,800个核苷酸至约3,400个核苷酸、约2,800个核苷酸至约3,200个核苷酸、约2,800个核苷酸至约3,000个核苷酸、约3,000个核苷酸至约10,000个核苷酸、约3,000个核苷酸至约9,500个核苷酸、约3,000个核苷酸至约9,000个核苷酸、约3,000个核苷酸至约8,500个核苷酸、约3,000个核苷酸至约8,000个核苷酸、约3,000个核苷酸至约7,800个核苷酸、约3,000个核苷酸至约7,600个核苷酸、约3,000个核苷酸至约7,400个核苷酸、约3,000个核苷酸至约7,200个核苷酸、约3,000个核苷酸至约7,000个核苷酸、约3,000个核苷酸至约6,800个核苷酸、约3,000个核苷酸至约6,600个核苷酸、约3,000个核苷酸至约6,400个核苷酸、约3,000个核苷酸至约6,200个核苷酸、约3,000个核苷酸至约6,000个核苷酸、约3,000个核苷酸至约5,800个核苷酸、约3,000个核苷酸至约5,600个核苷酸、约3,000个核苷酸至约5,400个核苷酸、约3,000个核苷酸至约5,200个核苷酸、约3,000个核苷酸至约5,000个核苷酸、约3,000个核苷酸至约4,800个核苷酸、约3,000个核苷酸至约4,600个核苷酸、约3,000个核苷酸至约4,400个核苷酸、约3,000个核苷酸至约4,200个核苷酸、约3,000个核苷酸至约4,000个核苷酸、约3,000个核苷酸至约3,800个核苷酸、约3,000个核苷酸至约3,600个核苷酸、约3,000个核苷酸至约3,400个核苷酸、约3,000个核苷酸至约3,200个核苷酸、约3,200个核苷酸至约10,000个核苷酸、约3,200个核苷酸至约9,500个核苷酸、约3,200个核苷酸至约9,000个核苷酸、约3,200个核苷酸至约8,500个核苷酸、约3,200个核苷酸至约8,000个核苷酸、约3,200个核苷酸至约7,800个核苷酸、约3,200个核苷酸至约7,600个核苷酸、约3,200个核苷酸至约7,400个核苷酸、约3,200个核苷酸至约7,200个核苷酸、约3,200个核苷酸至约7,000个核苷酸、约3,200个核苷酸至约6,800个核苷酸、约3,200个核苷酸至约6,600个核苷酸、约3,200个核苷酸至约6,400个核苷酸、约3,200个核苷酸至约6,200个核苷酸、约3,200个核苷酸至约6,000个核苷酸、约3,200个核苷酸至约5,800个核苷酸、约3,200个核苷酸至约5,600个核苷酸、约3,200个核苷酸至约5,400个核苷酸、约3,200个核苷酸至约5,200个核苷酸、约3,200个核苷酸至约5,000个核苷酸、约3,200个核苷酸至约4,800个核苷酸、约3,200个核苷酸至约4,600个核苷酸、约3,200个核苷酸至约4,400个核苷酸、约3,200个核苷酸至约4,200个核苷酸、约3,200个核苷酸至约4,000个核苷酸、约3,200个核苷酸至约3,800个核苷酸、约3,200个核苷酸至约3,600个核苷酸、约3,200个核苷酸至约3,400个核苷酸、约3,400个核苷酸至约10,000个核苷酸、约3,400个核苷酸至约9,500个核苷酸、约3,400个核苷酸至约9,000个核苷酸、约3,400个核苷酸至约8,500个核苷酸、约3,400个核苷酸至约8,000个核苷酸、约3,400个核苷酸至约7,800个核苷酸、约3,400个核苷酸至约7,600个核苷酸、约3,400个核苷酸至约7,400个核苷酸、约3,400个核苷酸至约7,200个核苷酸、约3,400个核苷酸至约7,000个核苷酸、约3,400个核苷酸至约6,800个核苷酸、约3,400个核苷酸至约6,600个核苷酸、约3,400个核苷酸至约6,400个核苷酸、约3,400个核苷酸至约6,200个核苷酸、约3,400个核苷酸至约6,000个核苷酸、约3,400个核苷酸至约5,800个核苷酸、约3,400个核苷酸至约5,600个核苷酸、约3,400个核苷酸至约5,400个核苷酸、约3,400个核苷酸至约5,200个核苷酸、约3,400个核苷酸至约5,000个核苷酸、约3,400个核苷酸至约4,800个核苷酸、约3,400个核苷酸至约4,600个核苷酸、约3,400个核苷酸至约4,400个核苷酸、约3,400个核苷酸至约4,200个核苷酸、约3,400个核苷酸至约4,000个核苷酸、约3,400个核苷酸至约3,800个核苷酸、约3,400个核苷酸至约3,600个核苷酸、约3,600个核苷酸至约10,000个核苷酸、约3,600个核苷酸至约9,500个核苷酸、约3,600个核苷酸至约9,000个核苷酸、约3,600个核苷酸至约8,500个核苷酸、约3,600个核苷酸至约8,000个核苷酸、约3,600个核苷酸至约7,800个核苷酸、约3,600个核苷酸至约7,600个核苷酸、约3,600个核苷酸至约7,400个核苷酸、约3,600个核苷酸至约7,200个核苷酸、约3,600个核苷酸至约7,000个核苷酸、约3,600个核苷酸至约6,800个核苷酸、约3,600个核苷酸至约6,600个核苷酸、约3,600个核苷酸至约6,400个核苷酸、约3,600个核苷酸至约6,200个核苷酸、约3,600个核苷酸至约6,000个核苷酸、约3,600个核苷酸至约5,800个核苷酸、约3,600个核苷酸至约5,600个核苷酸、约3,600个核苷酸至约5,400个核苷酸、约3,600个核苷酸至约5,200个核苷酸、约3,600个核苷酸至约5,000个核苷酸、约3,600个核苷酸至约4,800个核苷酸、约3,600个核苷酸至约4,600个核苷酸、约3,600个核苷酸至约4,400个核苷酸、约3,600个核苷酸至约4,200个核苷酸、约3,600个核苷酸至约4,000个核苷酸、约3,600个核苷酸至约3,800个核苷酸、约3,800个核苷酸至约10,000个核苷酸、约3,800个核苷酸至约9,500个核苷酸、约3,800个核苷酸至约9,000个核苷酸、约3,800个核苷酸至约8,500个核苷酸、约3,800个核苷酸至约8,000个核苷酸、约3,800个核苷酸至约7,800个核苷酸、约3,800个核苷酸至约7,600个核苷酸、约3,800个核苷酸至约7,400个核苷酸、约3,800个核苷酸至约7,200个核苷酸、约3,800个核苷酸至约7,000个核苷酸、约3,800个核苷酸至约6,800个核苷酸、约3,800个核苷酸至约6,600个核苷酸、约3,800个核苷酸至约6,400个核苷酸、约3,800个核苷酸至约6,200个核苷酸、约3,800个核苷酸至约6,000个核苷酸、约3,800个核苷酸至约5,800个核苷酸、约3,800个核苷酸至约5,600个核苷酸、约3,800个核苷酸至约5,400个核苷酸、约3,800个核苷酸至约5,200个核苷酸、约3,800个核苷酸至约5,000个核苷酸、约3,800个核苷酸至约4,800个核苷酸、约3,800个核苷酸至约4,600个核苷酸、约3,800个核苷酸至约4,200个核苷酸、约3,800个核苷酸至约4,000个核苷酸、约4,000个核苷酸至约10,000个核苷酸、约4,000个核苷酸至约9,500个核苷酸、约4,000个核苷酸至约9,000个核苷酸、约4,000个核苷酸至约8,500个核苷酸、约4,000个核苷酸至约8,000个核苷酸、约4,000个核苷酸至约7,800个核苷酸、约4,000个核苷酸至约7,600个核苷酸、约4,000个核苷酸至约7,400个核苷酸、约4,000个核苷酸至约7,200个核苷酸、约4,000个核苷酸至约7,000个核苷酸、约4,000个核苷酸至约6,800个核苷酸、约4,000个核苷酸至约6,600个核苷酸、约4,000个核苷酸至约6,400个核苷酸、约4,000个核苷酸至约6,200个核苷酸、约4,000个核苷酸至约6,000个核苷酸、约4,000个核苷酸至约5,800个核苷酸、约4,000个核苷酸至约5,600个核苷酸、约4,000个核苷酸至约5,400个核苷酸、约4,000个核苷酸至约5,200个核苷酸、约4,000个核苷酸至约5,000个核苷酸、约4,000个核苷酸至约4,800个核苷酸、约4,000个核苷酸至约4,600个核苷酸、约4,000个核苷酸至约4,400个核苷酸、约4,000个核苷酸至约4,200个核苷酸、约4,200个核苷酸至约10,000个核苷酸、约4,200个核苷酸至约9,500个核苷酸、约4,200个核苷酸至约9,000个核苷酸、约4,200个核苷酸至约8,500个核苷酸、约4,200个核苷酸至约8,000个核苷酸、约4,200个核苷酸至约7,800个核苷酸、约4,200个核苷酸至约7,600个核苷酸、约4,200个核苷酸至约7,400个核苷酸、约4,200个核苷酸至约7,200个核苷酸、约4,200个核苷酸至约7,000个核苷酸、约4,200个核苷酸至约6,800个核苷酸、约4,200个核苷酸至约6,600个核苷酸、约4,200个核苷酸至约6,400个核苷酸、约4,200个核苷酸至约6,200个核苷酸、约4,200个核苷酸至约6,000个核苷酸、约4,200个核苷酸至约5,800个核苷酸、约4,200个核苷酸至约5,600个核苷酸、约4,200个核苷酸至约5,400个核苷酸、约4,200个核苷酸至约5,200个核苷酸、约4,200个核苷酸至约5,000个核苷酸、约4,200个核苷酸至约4,800个核苷酸、约4,200个核苷酸至约4,600个核苷酸、约4,200个核苷酸至约4,400个核苷酸、约4,400个核苷酸至约10,000个核苷酸、约4,400个核苷酸至约9,500个核苷酸、约4,400个核苷酸至约9,000个核苷酸、约4,400个核苷酸至约8,500个核苷酸、约4,400个核苷酸至约8,000个核苷酸、约4,400个核苷酸至约7,800个核苷酸、约4,400个核苷酸至约7,600个核苷酸、约4,400个核苷酸至约7,400个核苷酸、约4,400个核苷酸至约7,200个核苷酸、约4,400个核苷酸至约7,000个核苷酸、约4,400个核苷酸至约6,800个核苷酸、约4,400个核苷酸至约6,600个核苷酸、约4,400个核苷酸至约6,400个核苷酸、约4,400个核苷酸至约6,200个核苷酸、约4,400个核苷酸至约6,000个核苷酸、约4,400个核苷酸至约5,800个核苷酸、约4,400个核苷酸至约5,600个核苷酸、约4,400个核苷酸至约5,400个核苷酸、约4,400个核苷酸至约5,200个核苷酸、约4,400个核苷酸至约5,000个核苷酸、约4,400个核苷酸至约4,800个核苷酸、约4,400个核苷酸至约4,600个核苷酸、约4,600个核苷酸至约10,000个核苷酸、约4,600个核苷酸至约9,500个核苷酸、约4,600个核苷酸至约9,000个核苷酸、约4,600个核苷酸至约8,500个核苷酸、约4,600个核苷酸至约8,000个核苷酸、约4,600个核苷酸至约7,800个核苷酸、约4,600个核苷酸至约7,600个核苷酸、约4,600个核苷酸至约7,400个核苷酸、约4,600个核苷酸至约7,200个核苷酸、约4,600个核苷酸至约7,000个核苷酸、约4,600个核苷酸至约6,800个核苷酸、约4,600个核苷酸至约6,600个核苷酸、约4,600个核苷酸至约6,400个核苷酸、约4,600个核苷酸至约6,200个核苷酸、约4,600个核苷酸至约6,000个核苷酸、约4,600个核苷酸至约5,800个核苷酸、约4,600个核苷酸至约5,600个核苷酸、约4,600个核苷酸至约5,400个核苷酸、约4,600个核苷酸至约5,200个核苷酸、约4,600个核苷酸至约5,000个核苷酸、约4,600个核苷酸至约4,800个核苷酸、约4,800个核苷酸至约10,000个核苷酸、约4,800个核苷酸至约9,500个核苷酸、约4,800个核苷酸至约9,000个核苷酸、约4,800个核苷酸至约8,500个核苷酸、约4,800个核苷酸至约8,000个核苷酸、约4,800个核苷酸至约7,800个核苷酸、约4,800个核苷酸至约7,600个核苷酸、约4,800个核苷酸至约7,400个核苷酸、约4,800个核苷酸至约7,200个核苷酸、约4,800个核苷酸至约7,000个核苷酸、约4,800个核苷酸至约6,800个核苷酸、约4,800个核苷酸至约6,600个核苷酸、约4,800个核苷酸至约6,400个核苷酸、约4,800个核苷酸至约6,200个核苷酸、约4,800个核苷酸至约6,000个核苷酸、约4,800个核苷酸至约5,800个核苷酸、约4,800个核苷酸至约5,600个核苷酸、约4,800个核苷酸至约5,400个核苷酸、约4,800个核苷酸至约5,200个核苷酸、约4,800个核苷酸至约5,000个核苷酸、约5,000个核苷酸至约10,000个核苷酸、约5,000个核苷酸至约9,500个核苷酸、约5,000个核苷酸至约9,000个核苷酸、约5,000个核苷酸至约8,500个核苷酸、约5,000个核苷酸至约8,000个核苷酸、约5,000个核苷酸至约7,800个核苷酸、约5,000个核苷酸至约7,600个核苷酸、约5,000个核苷酸至约7,400个核苷酸、约5,000个核苷酸至约7,200个核苷酸、约5,000个核苷酸至约7,000个核苷酸、约5,000个核苷酸至约6,800个核苷酸、约5,000个核苷酸至约6,600个核苷酸、约5,000个核苷酸至约6,400个核苷酸、约5,000个核苷酸至约6,200个核苷酸、约5,000个核苷酸至约6,000个核苷酸、约5,000个核苷酸至约5,800个核苷酸、约5,000个核苷酸至约5,600个核苷酸、约5,000个核苷酸至约5,400个核苷酸、约5,000个核苷酸至约5,200个核苷酸、约5,200个核苷酸至约10,000个核苷酸、约5,200个核苷酸至约9,500个核苷酸、约5,200个核苷酸至约9,000个核苷酸、约5,200个核苷酸至约8,500个核苷酸、约5,200个核苷酸至约8,000个核苷酸、约5,200个核苷酸至约7,800个核苷酸、约5,200个核苷酸至约7,600个核苷酸、约5,200个核苷酸至约7,400个核苷酸、约5,200个核苷酸至约7,200个核苷酸、约5,200个核苷酸至约7,000个核苷酸、约5,200个核苷酸至约6,800个核苷酸、约5,200个核苷酸至约6,600个核苷酸、约5,200个核苷酸至约6,400个核苷酸、约5,200个核苷酸至约6,200个核苷酸、约5,200个核苷酸至约6,000个核苷酸、约5,200个核苷酸至约5,800个核苷酸、约5,200个核苷酸至约5,600个核苷酸、约5,200个核苷酸至约5,400个核苷酸、约5,400个核苷酸至约10,000个核苷酸、约5,400个核苷酸至约9,500个核苷酸、约5,400个核苷酸至约9,000个核苷酸、约5,400个核苷酸至约8,500个核苷酸、约5,400个核苷酸至约8,000个核苷酸、约5,400个核苷酸至约7,800个核苷酸、约5,400个核苷酸至约7,600个核苷酸、约5,400个核苷酸至约7,400个核苷酸、约5,400个核苷酸至约7,200个核苷酸、约5,400个核苷酸至约7,000个核苷酸、约5,400个核苷酸至约6,800个核苷酸、约5,400个核苷酸至约6,600个核苷酸、约5,400个核苷酸至约6,400个核苷酸、约5,400个核苷酸至约6,200个核苷酸、约5,400个核苷酸至约6,000个核苷酸、约5,400个核苷酸至约5,800个核苷酸、约5,400个核苷酸至约5,600个核苷酸、约5,600个核苷酸至约10,000个核苷酸、约5,600个核苷酸至约9,500个核苷酸、约5,600个核苷酸至约9,000个核苷酸、约5,600个核苷酸至约8,500个核苷酸、约5,600个核苷酸至约8,000个核苷酸、约5,600个核苷酸至约7,800个核苷酸、约5,600个核苷酸至约7,600个核苷酸、约5,600个核苷酸至约7,400个核苷酸、约5,600个核苷酸至约7,200个核苷酸、约5,600个核苷酸至约7,000个核苷酸、约5,600个核苷酸至约6,800个核苷酸、约5,600个核苷酸至约6,600个核苷酸、约5,600个核苷酸至约6,400个核苷酸、约5,600个核苷酸至约6,200个核苷酸、约5,600个核苷酸至约6,000个核苷酸、约5,600个核苷酸至约5,800个核苷酸、约5,800个核苷酸至约10,000个核苷酸、约5,800个核苷酸至约9,500个核苷酸、约5,800个核苷酸至约9,000个核苷酸、约5,800个核苷酸至约8,500个核苷酸、约5,800个核苷酸至约8,000个核苷酸、约5,800个核苷酸至约7,800个核苷酸、约5,800个核苷酸至约7,600个核苷酸、约5,800个核苷酸至约7,400个核苷酸、约5,800个核苷酸至约7,200个核苷酸、约5,800个核苷酸至约7,000个核苷酸、约5,800个核苷酸至约6,800个核苷酸、约5,800个核苷酸至约6,600个核苷酸、约5,800个核苷酸至约6,400个核苷酸、约5,800个核苷酸至约6,200个核苷酸、约5,800个核苷酸至约6,000个核苷酸、约6,000个核苷酸至约10,000个核苷酸、约6,000个核苷酸至约9,500个核苷酸、约6,000个核苷酸至约9,000个核苷酸、约6,000个核苷酸至约8,500个核苷酸、约6,000个核苷酸至约8,000个核苷酸、约6,000个核苷酸至约7,800个核苷酸、约6,000个核苷酸至约7,600个核苷酸、约6,000个核苷酸至约7,400个核苷酸、约6,000个核苷酸至约7,200个核苷酸、约6,000个核苷酸至约7,000个核苷酸、约6,000个核苷酸至约6,800个核苷酸、约6,000个核苷酸至约6,600个核苷酸、约6,000个核苷酸至约6,400个核苷酸、约6,000个核苷酸至约6,200个核苷酸、约6,200个核苷酸至约10,000个核苷酸、约6,200个核苷酸至约9,000个核苷酸、约6,200个核苷酸至约8,500个核苷酸、约6,200个核苷酸至约8,000个核苷酸、约6,200个核苷酸至约7,800个核苷酸、约6,200个核苷酸至约7,600个核苷酸、约6,200个核苷酸至约7,400个核苷酸、约6,200个核苷酸至约7,200个核苷酸、约6,200个核苷酸至约7,000个核苷酸、约6,200个核苷酸至约6,800个核苷酸、约6,200个核苷酸至约6,600个核苷酸、约6,200个核苷酸至约6,400个核苷酸、约6,400个核苷酸至约10,000个核苷酸、约6,400个核苷酸至约9,500个核苷酸、约6,400个核苷酸至约9,000个核苷酸、约6,400个核苷酸至约8,500个核苷酸、约6,400个核苷酸至约8,000个核苷酸、约6,400个核苷酸至约7,800个核苷酸、约6,400个核苷酸至约7,600个核苷酸、约6,400个核苷酸至约7,400个核苷酸、约6,400个核苷酸至约7,200个核苷酸、约6,400个核苷酸至约7,000个核苷酸、约6,400个核苷酸至约6,800个核苷酸、约6,400个核苷酸至约6,600个核苷酸、约6,600个核苷酸至约10,000个核苷酸、约6,600个核苷酸至约9,500个核苷酸、约6,600个核苷酸至约9,000个核苷酸、约6,600个核苷酸至约8,500个核苷酸、约6,600个核苷酸至约8,000个核苷酸、约6,600个核苷酸至约7,800个核苷酸、约6,600个核苷酸至约7,600个核苷酸、约6,600个核苷酸至约7,400个核苷酸、约6,600个核苷酸至约7,200个核苷酸、约6,600个核苷酸至约7,000个核苷酸、约6,600个核苷酸至约6,800个核苷酸、约6,800个核苷酸至约10,000个核苷酸、约6,800个核苷酸至约9,500个核苷酸、约6,800个核苷酸至约9,000个核苷酸、约6,800个核苷酸至约8,500个核苷酸、约6,800个核苷酸至约8,000个核苷酸、约6,800个核苷酸至约7,800个核苷酸、约6,800个核苷酸至约7,600个核苷酸、约6,800个核苷酸至约7,400个核苷酸、约6,800个核苷酸至约7,200个核苷酸、约6,800个核苷酸至约7,000个核苷酸、约7,000个核苷酸至约10,000个核苷酸、约7,000个核苷酸至约9,500个核苷酸、约7,000个核苷酸至约9,000个核苷酸、约7,000个核苷酸至约8,500个核苷酸、约7,000个核苷酸至约8,000个核苷酸、约7,000个核苷酸至约7,800个核苷酸、约7,000个核苷酸至约7,600个核苷酸、约7,000个核苷酸至约7,400个核苷酸、约7,000个核苷酸至约7,200个核苷酸、约7,200个核苷酸至约10,000个核苷酸、约7,200个核苷酸至约9,500个核苷酸、约7,200个核苷酸至约9,000个核苷酸、约7,200个核苷酸至约8,500个核苷酸、约7,200个核苷酸至约8,000个核苷酸、约7,200个核苷酸至约7,800个核苷酸、约7,200个核苷酸至约7,600个核苷酸、约7,200个核苷酸至约7,400个核苷酸、约7,400个核苷酸至约10,000个核苷酸、约7,400个核苷酸至约9,500个核苷酸、约7,400个核苷酸至约9,000个核苷酸、约7,400个核苷酸至约8,500个核苷酸、约7,400个核苷酸至约8,000个核苷酸、约7,400个核苷酸至约7,800个核苷酸、约7,400个核苷酸至约7,600个核苷酸、约7,600个核苷酸至约10,000个核苷酸、约7,600个核苷酸至约9,500个核苷酸、约7,600个核苷酸至约9,000个核苷酸、约7,600个核苷酸至约8,500个核苷酸、约7,600个核苷酸至约8,000个核苷酸、约7,600个核苷酸至约7,800个核苷酸、约7,800个核苷酸至约10,000个核苷酸、约7,800个核苷酸至约9,500个核苷酸、约7,800个核苷酸至约9,000个核苷酸、约7,800个核苷酸至约8,500个核苷酸、约7,800个核苷酸至约8,000个核苷酸、约8,000个核苷酸至约10,000个核苷酸、约8,000个核苷酸至约9,500个核苷酸、约8,000个核苷酸至约9,000个核苷酸、约8,000个核苷酸至约8,500个核苷酸、约8,500个核苷酸至约10,000个核苷酸、约8,500个核苷酸至约9,500个核苷酸、约8,500个核苷酸至约9,000个核苷酸、约9,000个核苷酸至约10,000个核苷酸、约9,000个核苷酸至约9,500个核苷酸或约9,500个核苷酸至约10,000个核苷酸(包括端值)。
可使用本领域中已知的多种不同方法将本文公开的任何载体引入灵长类动物细胞(例如，支持耳蜗外毛细胞或毛细胞(例如，内毛细胞或外毛细胞))。用于将核酸引入灵长类动物细胞的方法的非限制性实例包括：脂质转染、转染(例如，磷酸钙转染、使用高度支化的有机化合物的转染、使用阳离子聚合物的转染、基于树状聚合物的转染、光学转染、基于颗粒的转染(例如，纳米颗粒转染)或使用脂质体(例如，阳离子脂质体)的转染)、显微注射、电穿孔、细胞挤压、声致穿孔、原生质体融合、穿刺转染、流体动力学递送、基因枪、磁转染、病毒转染和核转染。
本领域技术人员将理解，本文所述的任何载体可通过例如脂质转染法引入灵长类动物细胞。
可用于将一个或多个突变和/或一个或多个缺失引入内源基因的各种分子生物学技术在本领域中也是已知的。此类技术的非限制性示例包括定点诱变、CRISPR(例如，CRISPR/Cas9诱导的敲入突变和CRISPR/Cas9诱导的敲除突变)、TALEN和碱基编辑(Rees和Lui，Nature Rev.Genetics 19:770-788,2018；Eid等人，Biochem J.475(11):1955-1964,2018)。这些方法可用于校正存在于靶细胞染色体中的缺陷型内源基因的序列。
本文所述的任何载体还可包括控制序列，例如，选自由以下组成的组的控制序列：转录起始序列、转录终止序列、启动子序列、增强子序列、RNA剪接序列、多聚腺苷酸化(polyA)信号和Kozak共有序列。本文描述了这些控制序列的非限制性实例。在一些实施方案中，启动子可以是天然启动子、组成型启动子、诱导型启动子和/或组织特异性启动子。
本文所述的任何组合物和试剂盒的一些实施方案可包括本文所述的AAV载体的任意组合。本文所述的任何方法的一些实施方案可包括使用本文所述的AAV载体的任意组合。
启动子
术语“启动子”意指启动特定基因(例如，支持细胞靶基因或毛细胞靶基因)的转录所需的由灵长类动物细胞中的酶/蛋白质识别的DNA序列。启动子通常是指例如，与RNA聚合酶和/或任何相关因子结合并在其下启动转录的核苷酸序列。本文描述了启动子的非限制性实例。启动子的其它实例是本领域中已知的。
在一些实施方案中，编码毛细胞靶蛋白(例如，人毛细胞靶蛋白)或毛细胞靶蛋白的N-末端部分的载体可包含启动子和/或增强子。编码毛细胞靶蛋白的N-末端部分或毛细胞靶蛋白的载体可包含本文所述或本领域已知的任何启动子和/或增强子。
在一些实施方案中，编码支持细胞靶蛋白(例如，人支持细胞靶蛋白)的N-末端部分或支持细胞靶蛋白的载体可包含启动子和/或增强子。编码支持细胞靶蛋白的N末端部分或支持细胞靶蛋白的载体可包含本文所述或本领域已知的任何启动子和/或增强子。
在一些实施方案中，启动子是诱导型启动子、组成型启动子、灵长类动物细胞启动子、病毒启动子、嵌合启动子、工程启动子、组织特异性启动子或本领域已知的任何其它类型的启动子。在一些实施方案中，启动子为RNA聚合酶II启动子，诸如灵长类动物RNA聚合酶II启动子。在一些实施方案中，启动子是RNA聚合酶III启动子，包括但不限于H1启动子、人U6启动子、小鼠U6启动子或猪U6启动子。所述启动子通常是能够在诸如毛细胞等的耳蜗细胞中促进转录的启动子。在一些实例中，启动子为耳蜗特异性启动子或耳蜗定向的启动子。
可在本文中使用的多种启动子是本领域已知的。可用于本文的启动子的非限制性实例包括：人EF1a、人巨细胞病毒(CMV)(美国专利第5,168,062号)、人遍在蛋白C(UBC)、小鼠磷酸甘油酸激酶1、多瘤腺病毒、猿猴病毒40(SV40)、β-珠蛋白、β-肌动蛋白、α-甲胎蛋白、γ-珠蛋白、β-干扰素、γ-谷氨酰基转移酶、小鼠乳腺肿瘤病毒(MMTV)、劳斯肉瘤病毒、大鼠胰岛素、3-磷酸甘油醛脱氢酶、金属硫蛋白II(MT II)、淀粉酶、组织蛋白酶、MI毒蕈碱受体、逆转录病毒LTR(例如人T细胞白血病病毒HTLV)、AAV ITR、白介素-2、胶原酶、血小板衍生生长因子、腺病毒5E2、基质降解因子(stromelysin)、鼠MX基因、葡萄糖调节蛋白(GRP78和GRP94)、α-2-巨球蛋白、波形蛋白、MHC I类基因H-2κb、HSP70、增殖蛋白、肿瘤坏死因子、甲状腺刺激激素α基因、免疫球蛋白轻链、T细胞受体、HLA DQα和DQβ、白介素-2受体、II类MHC、II类MHC HLA-DRα、肌肉肌酸激酶、前白蛋白(转甲状腺素蛋白)、弹性蛋白酶I、白蛋白基因、c-fos、c-HA-ras、神经细胞粘附分子(NCAM)、H2B(TH2B)组蛋白、大鼠生长激素、人血清淀粉样蛋白(SAA)、肌钙蛋白I(TN I)、杜氏肌营养不良症、人免疫缺陷病毒和长臂猿白血病病毒(GALV)启动子。启动子的其它实例是本领域已知的。参见，例如，Lodish,Molecular Cell Biology,Freeman and Company,New York 2007。在一些实施方案中，启动子是CMV立即早期启动子。在一些实施方案中，启动子是CAG启动子或CAG/CBA启动子。
术语“组成型”启动子是指当与编码靶蛋白(例如，支持细胞靶蛋白、毛细胞靶蛋白)的核酸可操作地连接时，在大多数或所有生理条件下致使RNA从灵长类动物细胞中的核酸转录的核苷酸序列。
组成型启动子的实例包括但不限于逆转录病毒劳斯肉瘤病毒(RSV)LTR启动子、巨细胞病毒(CMV)启动子(参见，例如，Boshart等人，Cell 41:521-530,1985)、SV40启动子、二氢叶酸还原酶启动子、β-肌动蛋白启动子、磷酸甘油激酶(PGK)启动子和EF1-α启动子(Invitrogen)。
诱导型启动子允许调控基因表达，并且可以通过外源提供的化合物、环境因素(诸如温度)或特定生理状态(例如，急性期，细胞的特定分化状态)的存在或仅在复制细胞中来调控。诱导型启动子和诱导型系统可从多种商业来源获得，包括但不限于Invitrogen、Clontech和Ariad。诱导型启动子的其它实例是本领域中已知的。
由外源化合物调节的诱导型启动子的实例包括锌诱导型绵羊金属硫蛋白(MT)启动子、地塞米松(Dex)诱导型小鼠乳腺肿瘤病毒(MMTV)启动子、T7聚合酶启动子体系(WO98/10088)、蜕皮激素昆虫启动子(No等人，Proc.Natl.Acad.Sci.U.S.A.93:3346-3351,1996)、四环素抑制型体系(Gossen等人，Proc.Natl.Acad.Sci.U.S.A.89:5547-5551,1992)、四环素诱导型体系(Gossen等人，Science 268:1766-1769,1995,也参见Harvey等人，Curr.Opin.Chem.Biol.2:512-518,1998)、RU486诱导型体系(Wang等人，Nat.Biotech.15:239-243,1997)和Wang等人，Gene Ther.4:432-441,1997)以及雷帕霉素诱导型体系(Magari等人，J.Clin.Invest.100:2865-2872,1997)。
术语“组织特异性”启动子是指仅在某些特定细胞类型和/或组织中有活性(例如，特定基因的转录仅在表达与组织特异性启动子结合的转录调控蛋白的细胞内发生)的启动子。
在一些实施方案中，调控序列赋予组织特异性基因表达能力。在一些情况下，组织特异性调控序列结合以组织特异性方式诱导转录的组织特异性转录因子。
示例性的组织特异性启动子包括但不限于以下启动子：肝特异性甲状腺素结合球蛋白(TBG)启动子、胰岛素启动子、胰高血糖素启动子、生长抑素启动子、胰多肽(PPY)启动子、突触蛋白-1(Syn)启动子、肌酸激酶(MCK)启动子、灵长类动物结蛋白(DES)启动子、α-肌球蛋白重链(a-MHC)启动子和心脏肌钙蛋白T(cTnT)启动子。另外的示例性启动子包括β-肌动蛋白启动子、乙型肝炎病毒核心启动子(Sandig等人，Gene Ther.3:1002-1009,1996)、甲胎蛋白(AFP)启动子(Arbuthnot等人，Hum.Gene Ther.7:1503-1514,1996)、骨骨钙素启动子(Stein等人，Mol.Biol.Rep.24:185-196,1997)；骨唾液蛋白启动子(Chen等人，J.BoneMiner.Res.11:654-664,1996)、CD2启动子(Hansal等人，J.Immunol.161:1063-1068,1998)、免疫球蛋白重链启动子、T细胞受体α链启动子、神经元诸如神经元特异性烯醇化酶(NSE)启动子(Andersen等人，Cell.Mol.Neurobiol.13:503-515,1993)、神经丝轻链基因启动子(Piccioli等人，Proc.Natl.Acad.Sci.U.S.A.88:5611-5615,1991)和神经元特异性vgf基因启动子(Piccioli等人，Neuron 15:373-384,1995)。
在一些实施方案中，组织特异性启动子是耳蜗特异性启动子。在一些实施方案中，组织特异性启动子是耳蜗毛细胞特异性启动子。耳蜗毛细胞特异性启动子的非限制性实例包括但不限于：ATOH1启动子、POU4F3启动子、LHX3启动子、MYO7A启动子、MYO6启动子、α9ACHR启动子和α10ACHR启动子。在一些实施方案中，启动子是外毛细胞特异性启动子，诸如PRESTIN启动子或ONCOMOD启动子。参见，例如，Zheng等人，Nature 405:149-155,2000；Tian等人Dev.Dyn.231:199-203,2004；和Ryan等人，Adv.Otorhinolaryngol.66:99-115,2009。
在本文描述的任何AAV载体的一些实施方案中，AAV载体包含人ATOH1增强子-启动子(SEQ ID NO:84)。
人ATOH1增强子-启动子(SEQ ID NO:84)
ctatggagtttgcataacaaacgtttggcagctcgctctcttacactccattaacaagctgtaacatatagctgcaggttgctataatctcattaatattttggaaacttgaatattgagtatttctgagtgctcattccccatatgccagccacttctgccatgctgactggttcctttctctccattattagcaattagcttcttaccttccaaagtcagatccaaggtatccaagatactagcaaaggaatcaactatgtgtgcaagttaagcatgcttaatatcacccaaacaaacaaagaggcagcatttcttaaagtaatgaagatagataaatcgggttagtcctttgcgacactgctggtgctttctagagttttatatattttaagcagcttgctttatattctgtctttgcctcccaccccaccagcacttttatttgtggagggttttggctcgccacactttgggaaacttatttgatttcacggagagctgaaggaagatcatttttggcaacagacaagtttaaacacgatttctatgggacattgctaactggggcccctaaggagaaaggggaaactgagcggagaatgggttaaatccttggaagcaggggagaggcaggggaggagagaagtcggaggagtataaagaaaaggacaggaaccaagaagcgtgggggtggtttgccgtaatgtgagtgtttcttaattagagaacggttgacaatagagggtctggcagaggctcctggccgcggtgcggagcgtctggagcggagcacgcgctgtcagctggtgagcgcactctcctttcaggcagctccccggggagctgtgcggccacatttaacaccatcatcacccctccccggcctcctcaacctcggcctcctcctcgtcgacagccttccttggcccccaccagcagagctcacagtagcgagcgtctctcgccgtctcccgcactcggccggggcctctctcctcccccagctgcgcagcgggagccgccactgcccactgcacctcccagcaaccagcccagcacgcaaagaagctgcgcaaagttaaagccaagcaatgccaaggggaggggaagctggaggcgggctttgagtggcttctgggcgcctggcgggtccagaatcgcccagagccgcccgcggtcgtgcacatctgacccgagtcagcttgggcaccagccgagagccggctccgcaccgctcccgcaccccagccgccggggtggtgacacacaccggagtcgaattacagccctgcaattaacatatgaatctgacgaatttaaaagaaggaaaaaaaaaaaaaaacctgagcaggcttgggagtcctctgcacacaagaacttttctcggggtgtaaaaactctttgattggctgctcgcacgcgcctgcccgcgccctccattggctgagaagacacgcgaccggcgcgaggagggggttgggagaggagcggggggagactgagtggcgcgtgccgctttttaaaggggcgcagcgccttcagcaaccggagaagcatagttgcacgcgacctggtgtgtgatctccgagtgggtgggggagggtcgaggagggaaaaaaaaataagacgttgcagaagagacccggaaagggccttttttttggttgagctggtgtcccagtgctgcctccgatcctgagcctccgagcctttgcagtgcaa
增强子和5'帽
在一些情况下，载体可包含启动子序列和/或增强子序列。术语“增强子”是指可以升高编码目标蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)的核酸的转录水平的核苷酸序列。增强子序列(长度为50-1500个碱基对)通常通过为转录相关蛋白(例如，转录因子)提供额外的结合位点来升高转录水平。在一些实施方案中，在内含子序列内发现增强子序列。与启动子序列不同，增强子序列可以在距转录起始位点大得多的距离处起作用(例如，与启动子相比)。增强子的非限制性实例包括RSV增强子、CMV增强子和SV40增强子。
去稳定结构域(DD)
本文提供的任何AAV载体可以任选地包含编码去稳定结构域的序列(“去稳定序列”)，用于蛋白质表达的时间控制。去稳定序列的非限制性实例包括编码：FK506序列、二氢叶酸还原酶(DHFR)序列的序列。
示例性DHFR去稳定序列(SEQ ID NO:85):
MISLIAALAVDYVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPSTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVIEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
示例性DHFR去稳定结构域序列(SEQ ID NO:86)
ggtaccatcagtctgattgcggcgttagcggtagattacgttatcggcatggaaaacgccatgccgtggaacctgcctgccgatctcgcctggtttaaacgcaacaccttaaataaacccgtgattatgggccgccatacctgggaatcaatcggtcgtccgttgccaggacgcaaaaatattatcctcagcagtcaaccgagtacggacgatcgcgtaacgtgggtgaagtcggtggatgaagccatcgcggcgtgtggtgacgtaccagaaatcatggtgattggcggcggtcgcgttattgaacagttcttgccaaaagcgcaaaaactgtatctgacgcatatcgacgcagaagtggaaggcgacacccatttcccggattacgagccggatgactgggaatcggtattcagcgaattccacgatgctgatgcgcagaactctcacagctattgctttgagattctggagcggcgataa
在本文所述的任何AAV载体的一些实施方案中，AAV载体包含去稳定结构域(SEQID NO:87)。
示例性去稳定结构域(SEQ ID NO:87)
atcagtctgattgcggcgttagcggtagattacgttatcggcatggaaaacgccatgccgtggaacctgcctgccgatctcgcctggtttaaacgcaacaccttaaataaacccgtgattatgggccgccatacctgggaatcaatcggtcgtccgttgccaggacgcaaaaatattatcctcagcagtcaaccgagtacggacgatcgcgtaacgtgggtgaagtcggtggatgaagccatcgcggcgtgtggtgacgtaccagaaatcatggtgattggcggcggtcgcgttattgaacagttcttgccaaaagcgcaaaaactgtatctgacgcatatcgacgcagaagtggaaggcgacacccatttcccggattacgagccggatgactgggaatcggtattcagcgaattccacgatgctgatgcgcagaactctcacagctattgctttgagattctggagcggcga
去稳定序列的其它实例是本领域已知的。在一些实施方案中，去稳定序列是FK506和雷帕霉素结合蛋白(FKBP12)序列，并且稳定配体是Shield-1(Shld1)(Banaszynski等人，(2012)Cell 126(5):995-1004)。
示例性FKBP12去稳定序列(SEQ ID NO:88)
MGVEKQVIRPGNGPKPAPGQTVTVHCTGFGKDGDLSQKFWSTKDEGQKPFSFQIGKGAVIKGWDEGVIGMQIGEVARLRCSSDYAYGAGGFPAWGIQPNSVLDFEIEVLSVQ
在一些实施方案中，去稳定序列是DHFR序列，并且稳定配体是甲氧苄啶(TMP)(Iwamoto等人(2010)Chem Biol 17:981-988)。
在稳定配体不存在的情况下，与去稳定序列可操作地连接的蛋白质序列被泛遍在蛋白降解。相反，在稳定配体存在的情况下，蛋白质降解被抑制，从而使得与去稳定序列可操作地连接的蛋白质序列被主动表达。作为稳定蛋白质表达的阳性对照，蛋白质表达可通过常规手段检测，包括酶促测定法、放射照相测定法、比色测定法、荧光测定法或其它光谱测定法；荧光激活细胞分选(FACS)测定；免疫测定(例如，酶联免疫吸附测定(ELISA)、放射免疫测定(RIA)和免疫组织化学)。
在一些实施方案中，去稳定序列是FKBP12序列，并且通过蛋白质印迹检测在灵长类动物细胞(例如，支持性耳蜗外毛细胞)中携带FKBP12基因的AAV载体的存在。在一些实施方案中，去稳定序列可用于验证本文所述的任何AAV载体的时间特异性活性。
Poly(A)序列
在一些实施方案中，本文提供的任何载体可包含poly(A)序列。大多数新生的真核mRNA在其3’末端具有在复杂过程中添加的poly(A)尾，所述过程包括对初始转录物的切割以及偶联的多聚腺苷酸化反应(参见，例如，Proudfoot等人，Cell 108:501-512,2002)。Poly(A)尾赋予mRNA稳定性和可转移性(Molecular Biology of the Cell，第三版，B.Alberts等人，Garland Publishing,1994)。在一些实施方案中，poly(A)序列位于编码毛细胞靶蛋白的C末端的核酸序列的3'。在一些实施方案中，poly(A)序列位于编码支持细胞靶蛋白或目标蛋白(例如，Cas9内切核酸酶，例如，SaCas9内切核酸酶(例如，本文所述的任何SaCas9内切核酸酶)、报道蛋白(例如，GFP蛋白、mScarlet蛋白))的C末端的核酸序列的3’。
如本文所用，“多聚腺苷酸化”是指多聚腺苷酸基部分或其经修饰的变体与信使RNA分子的共价键联。在真核生物中，大多数信使RNA(mRNA)分子在3’末端被多腺苷酸化。3'poly(A)尾是通过酶聚腺苷酸聚合酶的作用添加到pre-mRNA上的长腺嘌呤核苷酸序列(例如，50、60、70、100、200、500、1000、2000、3000、4000或5000)。在高级真核生物中，将poly(A)尾添加到包含特定序列多腺苷酸化信号或“poly(A)序列”的转录物上。poly(A)尾和与其结合的蛋白质有助于保护mRNA免受外切核酸酶的降解。多腺苷酸化对于转录终止、mRNA从细胞核的输出以及翻译也很重要。DNA转录成RNA后，多腺苷酸化立即在细胞核中发生，但随后也可在细胞质中发生。转录终止后，mRNA链通过与RNA聚合酶相关联的内切核酸酶复合物的作用被切割。切割位点通常以在切割位点附近存在碱基序列AAUAAA为特征。切割mRNA后，腺苷残基被添加到切割位点处的游离3'末端。
如本文中所用，“poly(A)序列”是触发mRNA的内切核酸酶切割以及一系列腺苷在切割的mRNA的3'末端处的添加的序列。
可以使用几种poly(A)序列，包括那些源自牛生长激素(bgh)(Woychik等人，Proc.Natl.Acad.Sci.U.S.A.81(13):3944-3948,1984；美国专利第5,122,458号)、小鼠β-珠蛋白、小鼠α-珠蛋白(Orkin等人，EMBO J.4(2):453-456,1985；Thein等人，Blood 71(2):313-319,1988)、人胶原蛋白、多瘤病毒(Batt等人，Mol.Cell Biol.15(9):4783-4790,1995)、单纯疱疹病毒胸苷激酶基因(HSV TK)、IgG重链基因多腺苷酸化信号(US 2006/0040354)、人生长激素(hGH)(Szymanski等人，Mol.Therapy 15(7):1340-1347,2007)、SV40poly(A)位点的组，诸如SV40晚期和早期的poly(A)位点(Schek等人，Mol.Cell Biol.12(12):5386-5393,1992)的序列。
poly(A)序列可以是AATAAA的序列。AATAAA序列可被能够发出进行多腺苷酸化的信号的与AATAAA同源的其它六核苷酸序列取代，所述其它六核苷酸序列包括ATTAAA、AGTAAA、CATAAA、TATAAA、GATAAA、ACTAAA、AATATA、AAGAAA、AATAAT、AAAAAA、AATGAA、AATCAA、AACAAA、AATCAA、AATAAC、AATAGA、AATTAA或AATAAG(参见，例如，WO 06/12414)。
在一些实施方案中，poly(A)序列可以是合成多腺苷酸化位点(参见，例如，Promega的pCl-neo表达载体，其基于Levitt等人，Genes Dev.3(7):1019-1025,1989)。在一些实施方案中，poly(A)序列为可溶性神经菌毛素-1(sNRP)(AAATAAAATACGAAATG,SEQ IDNO:90)的多聚腺苷酸化信号(参见，例如，WO 05/073384)。poly(A)序列的其它实例是本领域已知的。
内部核糖体进入位点(IRES)
在一些实施方案中，编码毛细胞靶蛋白的C末端或毛细胞靶蛋白的载体可包括多核苷酸内部核糖体进入位点(IRES)。在一些实施方案中，编码支持细胞靶蛋白的C末端或支持细胞靶蛋白的载体可包含多核苷酸内部核糖体进入位点(IRES)。IRES序列用于由单一基因转录物产生不止一种多肽。IRES形成复杂的二级结构，所述二级结构允许从紧接IRES所在位置下游的mRNA中的任何位置进行翻译起始(参见，例如，Pelletier和Sonenberg,Mol.Cell.Biol.8(3):1103-1112,1988)。
存在本领域技术人员已知的几种IRES序列，包括来自例如口蹄疫病毒(FMDV)、脑心肌炎病毒(EMCV)、人鼻病毒(HRV)、蟋蟀麻痹病毒，人免疫缺陷病毒(HIV)、甲型肝炎病毒(HAV)、丙型肝炎病毒(HCV)和脊髓灰质炎病毒(PV)的那些IRES序列。参见，例如，Alberts,Molecular Biology of the Cell,Garland Science,2002；和Hellen等人，Genes Dev.15(13):1593-612,2001。
在一些实施方案中，整合到编码毛细胞靶蛋白的C-末端或毛细胞靶蛋白的载体中的IRES序列是口蹄疫病毒(FMDV)。在一些实施方案中，整合到编码支持细胞靶蛋白的C末端或支持细胞靶蛋白的载体中的IRES序列是口蹄疫病毒(FMDV)2A序列。在一些实施方案中，整合到编码目标蛋白质(例如，Cas9内核酸切酶，例如SaCas9内切核酸酶(例如，本文所述的任何SaCas9内切核酸酶))的C-末端部分的载体中的IRES序列是FMDV 2A序列。口蹄疫病毒2A序列为小肽(长度为约18个氨基酸)，已证明其介导多蛋白的裂解(Ryan,M D等人，EMBO 4:928-933,1994；Mattion等人，J.Virology 70:8124-8127,1996；Furler等人，GeneTherapy 8:864-873,2001；和Halpin等人，Plant Journal 4:453-459,1999)。先前已在包括质粒和基因治疗载体(AAV和逆转录病毒)的人工体系中证明了2A序列的切割活性(Ryan等人，EMBO 4:928-933,1994；Mattion等人，J.Virology 70:8124-8127,1996；Furler等人，Gene Therapy 8:864-873,2001；和Halpin等人，Plant Journal 4:453-459,1999；deFelipe等人，Gene Therapy 6:198-208,1999；de Felipe等人，Human Gene Therapy 11:1921-1931,2000；和Klump等人，Gene Therapy 8:811-817,2001)。
报告基因序列/可检测标记基因
本文提供的任何载体可以任选地包含编码报告蛋白或可检测标记的序列(“报告序列”或“可检测标记基因”)。报告序列或可检测标记基因的非限制性实例包括DNA序列，所述DNA序列编码：β-内酰胺酶、β-半乳糖苷酶(LacZ)、碱性磷酸酶、胸苷激酶、绿色荧光蛋白(GFP)、红色荧光蛋白、mCherry荧光蛋白、黄色荧光蛋白、氯霉素乙酰基转移酶(CAT)和萤光素酶。报告序列和可检测标记基因的其它实例是本领域已知的。当与驱动其表达的调控元件缔合时，报告序列和可检测标记基因可提供可通过常规手段检测的信号，所述常规手段包括酶促测定、放射摄影测定、比色测定、荧光测定或其它光谱测定；荧光激活细胞分选(FACS)测定；免疫测定(例如，酶联免疫吸附测定(ELISA)、放射免疫测定(RIA)和免疫组织化学)。
在一些实施方案中，报告序列或可检测标记基因是LacZ基因，并且通过测定β-半乳糖苷酶活性来检测灵长类动物细胞(例如，支持耳蜗外毛细胞或毛细胞(例如，耳蜗外毛细胞或耳蜗内毛细胞))中携带LacZ基因的载体的存在。在其它实施方案中，报告子或可检测标记是荧光蛋白(例如，绿色荧光蛋白)或萤光素酶，灵长类动物细胞(例如，支持耳蜗外毛细胞或毛细胞(例如，耳蜗外毛细胞或耳蜗内毛细胞))中携带荧光蛋白或萤光素酶的载体的存在可通过荧光技术(例如，荧光显微镜检查或FACS)或光度计(例如，分光光度计或IVIS成像仪)中的光产生来测量。在一些实施方案中，可使用报告序列或可检测标记来验证本文所述的任何载体的组织特异性靶向能力和组织特异性启动子调控活性。
侧翼区非翻译区(UTR)
在一些实施方案中，本文所述的任何载体(例如，所述至少两种不同的载体中的任一种)可包括非翻译区。在一些实施方案中，载体可包含5'UTR或3’UTR。
基因的非翻译区(UTR)被转录但未被翻译。5’UTR从转录起始位点开始，并继续至起始密码子，但不包括起始密码子。3'UTR在终止密码子之后立即开始，并且继续直到转录终止信号。越来越多的证据表明，UTR在核酸分子的稳定性和翻译方面起调控作用。可将UTR的调控特征整合到本文所述的任何载体、组合物、试剂盒或方法中，以增强支持细胞靶蛋白或毛细胞靶蛋白或目标蛋白(例如，Cas9内切核酸酶，例如SaCas9内切核酸酶(例如，本文所述的任何SaCas9内切核酸酶)、报告蛋白(例如，GFP蛋白、mScarlet蛋白))的稳定性。
天然的5'UTR包括在翻译起始中起作用的序列。它们带有类似Kozak序列的标签(signature)，众所周知，所述序列参与核糖体籍以启动许多基因翻译的过程。Kozak序列具有共有序列CCR(A/G)CCAUGG，其中R是起始密码子(AUG)上游三个碱基的嘌呤(A或G)，其后紧接另一个“G”。还已知5’UTR例如形成参与伸长因子结合的二级结构。
例如，在一些实施方案中，5'UTR包含在本文所述的任何载体中。包括来自以下基因的那些在内的5'UTR的非限制性实例：白蛋白、血清淀粉样蛋白A、载脂蛋白A/B/E、转铁蛋白、甲胎蛋白、促红细胞生成素和因子VIII，可用于增强诸如mRNA等的核酸分子的表达。
在一些实施方案中，来自由耳蜗中的细胞转录的mRNA的5'UTR可包括在本文所述的任何载体、组合物、试剂盒和方法中。
已知3'UTR在其中嵌入了腺苷段和尿苷段。这些富含AU的标签在具有高周转率的基因中特别普遍。基于序列特征和功能特性，富含AU的元件(ARE)可以分为三类(Chen等人，Mol.Cell.Biol.15:5777-5788,1995；Chen等人，Mol.Cell Biol.15:2010-2018,1995)：I类ARE在富含U的区域中包含几个分散的AUUUA基序拷贝。例如，c-Myc和MyoD mRNA包含I类ARE。II类ARE具有两个或多个重叠的UUAUUUA(U/A)(U/A)九聚体。GM-CSF和TNF-αmRNA是含有II类ARE的实例。III类ARE的定义不太明确。这些富含U的区域不含AUUUA基序。该类的两个经过充分研究的实例是c-Jun和肌细胞生成素mRNA。
已知大多数与ARE结合的蛋白质都会使信使不稳定，然而ELAV家族的成员(尤其是HuR)已被证明增强mRNA的稳定性。HuR与所有这三个类别的ARE结合。将HuR特异性结合位点工程化到核酸分子的3'UTR内将导致HuR结合，并因此在体内稳定信息。
在一些实施方案中，3’UTR ARE的引入、去除或修饰可用于调节编码毛细胞靶蛋白的mRNA的稳定性。在一些实施方案中，3’UTR ARE的引入、去除或修饰可用于调节编码支持细胞靶蛋白的mRNA的稳定性。在其它实施方案中，ARE可被去除或突变以增强细胞内稳定性，并因此增加毛细胞靶蛋白的翻译和产生。在其它实施方案中，ARE可以被去除或突变以增强细胞内稳定性，从而增加支持细胞靶蛋白的翻译和产生。
在其它实施方案中，可将非UTR序列可整合到5'或3'UTR中。在一些实施方案中，内含子或内含子序列的一部分可并入本文提供的任何载体、组合物、试剂盒和方法中的多核苷酸的侧翼区中。内含子序列的并入可增加蛋白质产生以及mRNA水平。
灵长类动物细胞
本文还提供了细胞(例如，灵长类动物细胞)，其包含核酸、载体(例如，本文所述的至少两种不同的载体)或本文所述的组合物中的任一者。在一些实施方案中，灵长类动物细胞是人细胞(例如，人支持细胞或人毛细胞)。在其它实施方式中，灵长类动物是非人灵长类动物(例如，猿猴细胞(例如，猴细胞(例如，狨猴细胞、狒狒细胞、猕猴细胞)或猿类细胞(例如，大猩猩细胞、长臂猿细胞、猩猩细胞、黑猩猩细胞))。技术人员将理解，可以将本文所述的核酸和载体引入任何灵长类动物细胞(例如，灵长类动物支持细胞或灵长类动物毛细胞)中。本文描述了载体和用于将载体引入灵长类动物细胞的方法的非限制性实例。
在一些实施方案中，灵长类动物细胞可以是哺乳动物内耳的支持毛细胞。例如，支持细胞可以是亨森氏细胞、Deiters氏细胞、内柱细胞、外柱细胞、Claudius细胞、内边界细胞、内指细胞或血管纹细胞。
在一些实施方案中，灵长类动物细胞是耳蜗的特化细胞。在一些实施方案中，灵长类动物细胞是毛细胞。在一些实施方案中，灵长类动物细胞是耳蜗内毛细胞或耳蜗外毛细胞。在一些实施方案中，灵长类动物细胞是耳蜗内毛细胞。在一些实施方案中，灵长类动物细胞是耳蜗外毛细胞。
在一些实施方案中，灵长类动物细胞是体外的。在一些实施方案中，灵长类动物细胞存在于灵长类动物中。在一些实施方案中，灵长类动物细胞是获自灵长类动物并且离体培养的自体细胞。
方法
本文还提供了校正灵长类动物内耳的毛细胞中的毛细胞靶基因缺陷的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用修复所述灵长类动物内耳的毛细胞中的毛细胞靶基因缺陷。
本文还提供了升高灵长类动物内耳的毛细胞中的毛细胞靶蛋白的表达水平的方法，所述方法包括向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用使得所述灵长类动物内耳的所述毛细胞中的所述毛细胞靶蛋白的表达水平升高。
本文还提供了治疗被鉴定为具有缺陷型毛细胞靶基因的灵长类动物的听力损失(例如，非综合征性感音神经性听力损失或综合征性感音神经性听力损失)的方法，所述方法包括：向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。
在这些方法中的任一种的一些实施方案中，灵长类动物先前已被鉴定为具有缺陷型毛细胞靶基因(例如，具有突变的毛细胞靶基因，所述突变导致由所述基因编码的毛细胞靶蛋白的表达和/或活性降低)。这些方法中的任一种的一些实施方案还包括，在引入或施用步骤之前，确定灵长类动物具有缺陷型毛细胞靶基因。这些方法中的任一种的一些实施方案还可包括检测灵长类动物的毛细胞靶基因中的突变。所述方法中的任一种的一些实施方案还可包括将灵长类动物鉴定或诊断为患有非综合征性感音神经性听力损失。所述方法中的任一种的一些实施方案还可包括将灵长类动物鉴定或诊断为患有综合征性感音神经性听力损失。
本文还提供了校正灵长类动物内耳的支持细胞中的支持细胞靶基因缺陷的方法，所述方法包括：向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用修复所述灵长类动物内耳的支持细胞中的支持细胞靶基因缺陷。
本文还提供了升高灵长类动物内耳的支持细胞中的支持细胞靶蛋白的表达水平的方法，所述方法包括向所述灵长类动物的内耳施用治疗有效量的本文所述的任何组合物，其中所述施用使得所述灵长类动物内耳的支持细胞中的所述支持细胞靶蛋白的表达水平升高。
本文还提供了治疗被鉴定为具有缺陷型支持细胞靶基因的灵长类动物的听力损失(例如，非综合征性感音神经性听力损失或综合征性感音神经性听力损失)的方法，所述方法包括：向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。
本文还提供了恢复被鉴定或诊断为患有听力损失的灵长类动物的听力的方法，所述方法包括：向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。
本文还提供了恢复被鉴定或诊断为患有内耳病症的灵长类动物的突触并且/或者保存其螺旋神经节神经的方法，所述方法包括：向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物。
本文还提供了包括向灵长类动物的内耳施用治疗有效量的本文所述的任何组合物的方法。
在这些方法中的任一种的一些实施方案中，灵长类动物先前已经被鉴定为具有缺陷型支持细胞靶基因(例如，具有突变的支持细胞靶基因，所述突变导致由所述基因编码的支持细胞靶蛋白的表达和/或活性降低)。这些方法中的任一种的一些实施方案还包括在引入或施用步骤之前，确定灵长类动物具有缺陷型支持细胞靶基因。这些方法中的任一种的一些实施方案还可包括检测灵长类动物中的支持细胞靶基因中的突变。所述方法中的任一种的一些实施方案还可包括将灵长类动物鉴定或诊断为患有非综合征性感音神经性听力损失。所述方法中的任一种的一些实施方案还可包括将灵长类动物鉴定或诊断为患有综合征性感音神经性听力损失。
在这些方法中的任一种的一些实施方案中，将两个或更多个剂量的本文所述的任何组合物引入或施用到灵长类动物的耳蜗中。这些方法中的任一种的一些实施方案可包括将第一剂量的组合物引入或施用到灵长类动物的耳蜗中，在引入或施用第一剂量后评估灵长类动物的听力功能，并且向发现在正常范围内没有听力功能(例如，如使用本领域已知的任何听力测试所确定的)的灵长类动物的耳蜗中施用额外剂量的组合物。
在本文所述的任何方法的一些实施方案中，组合物可被配制成用于耳蜗内施用。在本文所述的任何方法的一些实施方案中，可通过耳蜗内施用或局部施用来施用本文所述的组合物。在本文所述的任何方法的一些实施方案中，通过使用医疗装置(例如，本文所述的任何示例性医疗装置)来施用组合物。
在一些实施方案中，可使用本文所述或本领域已知的任何方法来进行耳蜗内施用。例如，可使用以下手术技术将组合物施用或引入到耳蜗中：首先使用0度、2.5mm的刚性内窥镜进行可视化，清理外耳道并使用圆刀清晰划定约5mm的鼓膜瓣。然后，将鼓膜瓣抬高，并向后进入中耳。识别并分离鼓索神经，并使用刮匙去除缝骨(scutal bone)，从而暴露圆窗膜。为了增强所施用或引入的组合物的顶端分布，可使用手术激光在椭圆窗口中做一个小的2mm的开窗，以允许组合物的经圆窗膜输注过程中的外淋巴移位。然后，准备好微输注装置并带入手术区域。将装置移动到圆窗，并且将尖端放置在骨状圆窗悬垂物内，以允许一个或多个微针穿透膜。接合踏板以允许对组合物进行测量、稳定地输注。然后，取出装置并使用明胶海绵贴片密封圆窗和镫骨足板。
在本文所述的任何方法的一些实施方案中，灵长类动物患有非综合征性感音神经性听力损失或有发展非综合征性感音神经性听力损失的风险。在本文所述的任何方法的一些实施方案中，所述灵长类动物先前已被鉴定为在毛细胞靶基因中具有突变。在本文所述的任何方法的一些实施方案中，所述灵长类动物先前已被鉴定为在支持细胞靶基因中具有突变。在本文所述的任何方法的一些实施方案中，灵长类动物在毛细胞靶基因具有任何突变，所述突变在本文中被描述成或在本领域中已知与非综合征性感音神经性听力损失或综合征性感音神经性听力损失相关联。在本文所述的任何方法的一些实施方案中，灵长类动物在支持细胞靶基因中具有任何突变，所述突变在本文中被描述成或在本领域已知与非综合征性感音神经性听力损失或综合征性感音神经性听力损失相关联。
在本文所述的任何方法的一些实施方案中，所述灵长类动物已被鉴定为毛细胞靶基因中的突变的携带者(例如，通过遗传测试)。在本文所述的任何方法的一些实施方案中，灵长类动物已被鉴定为支持细胞靶基因中的突变的携带者(例如，通过遗传测试)。在本文所述的任何方法的一些实施方案中，灵长类动物已被鉴定为在毛细胞靶基因中具有突变并且已被诊断患有听力损失(例如，非综合征性感音神经性听力损失或综合征性感音神经性听力损失)。在本文所述的任何方法的一些实施方案中，灵长类动物已被鉴定为在支持细胞靶基因中具有突变，并已被诊断为患有听力损失(例如，非综合征性感音神经性听力损失或综合征性感音神经性听力损失)。在本文所述的任何方法的一些实施方案中，灵长类动物已被鉴定为患有听力损失(例如，非综合征性感音神经性听力损失或综合征性感音神经性听力损失)。
在一些实施方案中，可使用本领域已知的任何常规功能性听力测试在灵长类动物中确定听力损失(例如，非综合征性感音神经性听力损失或综合征性感音神经性听力损失)的成功治疗。功能性听力测试的非限制性实例是各种类型的听力测定(例如，纯音测试、语音测试、中耳测试、听觉脑干反应和耳声发射)。
在这些方法的一些实施方案中，灵长类动物细胞是体外的。在这些方法的一些实施方案中，灵长类动物细胞最初获自灵长类动物并且是离体培养的。在一些实施方案中，灵长类动物细胞先前已被确定具有缺陷型毛细胞靶基因。在一些实施方案中，灵长类动物细胞先前已被确定具有缺陷型支持细胞靶基因。
用于将本文所述的任何组合物引入灵长类动物细胞中的方法(例如，通过脂质转染或通过使用病毒载体，例如，本文所述的任何病毒载体)是本领域已知的。
如本文所述的活性靶蛋白(例如，活性支持细胞靶蛋白(例如，全长支持细胞靶蛋白)或活性毛细胞靶蛋白(例如，全长毛细胞靶蛋白)的表达增加是例如与对照或与引入一种或多种载体之前的活性靶蛋白(例如，活性支持细胞靶蛋白(例如，全长支持细胞靶蛋白)或活性毛细胞靶蛋白(例如，全长毛细胞靶蛋白)的表达水平相比的。
检测靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)的表达和/或活性的方法是本领域已知的。在一些实施方案中，可以直接检测毛细胞靶蛋白的表达水平(例如，检测毛细胞靶蛋白或检测毛细胞靶mRNA)。在一些实施方案中，可以直接检测支持细胞靶蛋白的表达水平(例如，检测支持细胞靶蛋白或检测支持细胞靶mRNA)。可用于检测靶蛋白(例如，支持细胞靶蛋白或毛细胞靶蛋白)的表达和/或活性的技术的非限制性示例直接包括：实时PCR、蛋白质印迹、免疫沉淀、免疫组织化学或免疫荧光。在一些实施方案中，可以间接检测毛细胞靶蛋白的表达(例如，通过功能性听力测试)。在一些实施方案中，可以间接检测支持细胞靶蛋白的表达(例如，通过功能性听力测试)。
药物组合物和试剂盒
在一些实施方案中，本文所述的任何组合物还可包含一种或多种促进本文所述的核酸或任何载体进入灵长类动物细胞的剂(例如，脂质体或阳离子脂质)。
在一些实施方案中，可使用天然和/或合成聚合物来配制本文所述的任何载体。可包含在本文所述的任何组合物中的聚合物的非限制性实例可包括但不限DYNAMIC
Figure BDA0003112389540005931
(Arrowhead Research Corp.,Pasadena,Calif.)、来自MirusBio(Madison,Wis.)和Roche Madison(Madison,Wis.)的制剂、PhaseRX聚合物制剂，诸如但不限于SMARTT POLYMER
Figure BDA0003112389540005932
(PhaseRX,Seattle,Wash.)、DMRI/DOPE、泊洛沙姆、来自Vical(San Diego,Calif.)的
Figure BDA0003112389540005933
佐剂、壳聚糖、来自CalandoPharmaceuticals(Pasadena,Calif.)的环糊精、树状聚合物和聚(乳酸-共-羟基乙酸)(PLGA)聚合物、RONDELTM(RNAi/寡核苷酸纳米颗粒递送)聚合物(Arrowhead ResearchCorporation,Pasadena,Calif.)和pH响应性共嵌段聚合物，诸如但不限于PhaseRX(Seattle,Wash.)生产的那些pH响应性共嵌段聚合物。这些聚合物中的许多已证明了在体内将寡核苷酸递送至灵长类动物细胞中的功效(参见，例如，deFougerolles,Human GeneTher.19:125-132,2008；Rozema等人，Proc.Natl.Acad.Sci.U.S.A.104:12982-12887,2007；Rozema等人，Proc.Natl.Acad.Sci.U.S.A.104:12982-12887,2007；Hu-Lieskovan等人，Cancer Res.65:8984-8982,2005；Heidel等人，Proc.Natl.Acad.Sci.U.S.A.104:5715-5721,2007)。
本文所述的任何组合物可以是例如药物组合物。药物组合物可包含本文所述的任何组合物和一种或多种药学上或生理上可接受的载体、稀释剂或赋形剂。此类组合物可包含一种或多种缓冲剂，诸如中性缓冲盐溶液、磷酸盐缓冲盐溶液等；一种或多种碳水化合物，诸如葡萄糖、甘露糖、蔗糖和葡聚糖；甘露醇；一种或多种蛋白质、多肽或氨基酸，诸如甘氨酸；一种或多种抗氧化剂；一种或多种螯合剂，诸如EDTA或谷胱甘肽；和/或一种或多种防腐剂。
在一些实施方案中，组合物包含药学上可接受的载体(例如，磷酸盐缓冲盐水、盐水或抑菌水)。当配制时，溶液以与剂量制剂相容的方式和以治疗有效的量施用。制剂以诸如可注射溶液、可注射凝胶、药物释放胶囊剂等多种剂型容易地施用。
如本文中所用，术语“药学上可接受的载体”包括与药物施用相容的溶剂、分散介质、包衣、抗细菌剂、抗真菌剂等。还可将补充性活性化合物掺入本文所述的任何组合物中。
在一些实施方案中，本文所述的任何组合物的单剂量可在例如缓冲液中包含以下量的合计量的至少两种不同的载体：至少1ng、至少2ng、至少4ng、约6ng、约8ng、至少10ng、至少20ng、至少30ng、至少40ng、至少50ng、至少60ng、至少70ng、至少80ng、至少90ng、至少100ng、至少200ng、至少300ng、至少400ng、至少500ng、至少1μg、至少2μg、至少4μg、至少6μg、至少8μg、至少10μg、至少12μg、至少14μg、至少16μg、至少18μg、至少20μg、至少22μg、至少24μg、至少26μg、至少28μg、至少30μg、至少32μg、至少34μg、至少36μg、至少38μg、至少40μg、至少42μg、至少44μg、至少46μg、至少48μg、至少50μg、至少52μg、至少54μg、至少56μg、至少58μg、至少60μg、至少62μg、至少64μg、至少66μg、至少68μg、至少70μg、至少72μg、至少74μg、至少76μg、至少78μg、至少80μg、至少82μg、至少84μg、至少86μg、至少88μg、至少90μg、至少92μg、至少94μg、至少96μg、至少98μg、至少100μg、至少102μg、至少104μg、至少106μg、至少108μg、至少110μg、至少112μg、至少114μg、至少116μg、至少118μg、至少120μg、至少122μg、至少124μg、至少126μg、至少128μg、至少130μg、至少132μg、至少134μg、至少136μg、至少138μg、至少140μg、至少142μg、至少144μg、至少146μg、至少148μg、至少150μg、至少152μg、至少154μg、至少156μg、至少158μg、至少160μg、至少162μg、至少164μg、至少166μg、至少168μg、至少170μg、至少172μg、至少174μg、至少176μg、至少178μg、至少180μg、至少182μg、至少184μg、至少186μg、至少188μg、至少190μg、至少192μg、至少194μg、至少196μg、至少198μg或至少200μg。
可以例如将本文提供的组合物配制成与其预期的施用途径相容。预期施用途径的非限制性实例是局部施用(例如，耳蜗内施用)。
在一些实施方案中，所述治疗性组合物被配制成包含脂质纳米颗粒。在一些实施方案中，所述治疗性组合物被配制成包含聚合物纳米颗粒。在一些实施方案中，所述治疗性组合物被配制成包含小环DNA。在一些实施方案中，治疗性组合物被配制成包含CELiD DNA。在一些实施方案中，治疗性组合物被配制成包含合成外淋巴液。一种示例性合成淋巴溶液包括20-200mM NaCl；1-5mM KCl；0.1-10mM CaCl2；1-10mM葡萄糖；2-50mM HEPES，pH值在约6与约9之间。
本文还提供了包括本文所述的任何组合物的试剂盒。在一些实施方案中，试剂盒可包括固体组合物(例如，包含本文所述的至少两种不同的载体的冻干组合物)和用于增溶冻干组合物的液体。在一些实施方案中，试剂盒可包括预装式注射器，所述预装式注射器包含本文所述的任何组合物。
在一些实施方案中，试剂盒包括小瓶，所述小瓶包含本文所述的任何组合物(例如，配制成水性组合物，例如，水性药物组合物)。
在一些实施方案中，试剂盒可包括用于进行本文所述的任何方法的说明书。
装置和手术方法
本文提供了用于治疗听力损失(例如，非综合征性感音神经性听力损失或综合征性感音神经性听力损失)的治疗性递送系统。一方面，所述治疗性递送体系包括i)能够在有需要的灵长类动物的内耳的圆窗膜中产生一个或多个切口的医疗装置，和ii)有效剂量的组合物(例如，本文所述的任何组合物)。在一些实施方案中，所述医疗装置包括多个微针。
本文还提供了用于治疗听力损失(例如，非综合征性感音神经性听力损失或综合征性感音神经性听力损失)的手术方法。在一些实施方案中，所述方法包括以下步骤：在第一切口点处将第一切口引入灵长类动物的耳蜗中；以及耳蜗内施用治疗有效量的本文提供的任何组合物。在一些实施方案中，将组合物在第一切口点处施用于灵长类动物。在一些实施方案中，将组合物施用于灵长类动物，进入或通过第一切口。
在本文所述的任何方法的一些实施方案中，将本文所述的任何组合物施用于灵长类动物，进入或通过耳蜗椭圆形窗膜。在本文所述的任何方法的一些实施方案中，将本文所述的任何组合物施用于灵长类动物，进入或通过耳蜗圆窗膜。在本文描述的任何方法的一些实施方案中，使用能够在圆窗膜上产生多个切口的医疗装置来施用组合物。在一些实施方案中，所述医疗装置包括多个微针。在一些实施方案中，所述医疗装置包括多个微针，所述多个微针包括一般圆形的第一方面，其中每个微针的直径至少约为10微米。在一些实施方案中，所述医疗装置包括能够容纳所述组合物的基座和/或储器。在一些实施方案中，医疗装置包括多个空心微针，所述多个空心微针各自包括能够转移组合物的内腔。在一些实施方案中，医疗装置包括用于产生至少部分真空的工具。
通过参考以下实验实施例进一步详细描述本发明。这些实施例仅出于说明的目的而提供，并且除非另有说明，否则不意图进行限制。因此，本发明决不应解释为限于以下实施例，而应解释为涵盖由于本文提供的教导而变得显而易见的任何和所有变型。
无需进一步描述，相信本领域普通技术人员可以使用前述的描述和以下说明性实施例，制备和利用本发明的化合物并实践所要求保护的方法。以下工作实施例特别指出本发明的各个方面，并且不应当被解释为以任何方式限制本公开的其余部分。
实施例
实施例1.AAV单一载体注射至内耳中
在通过圆形窗口将单一的Anc80-GFP AAV载体直接施用到内耳中后，对食蟹猕猴(非人灵长类动物)的耳蜗组织进行免疫荧光染色。
使用Myo7a作为毛细胞的标志物以及Iba-1作为巨噬细胞的标志物，对来自处理过的猕猴的耳蜗组织进行免疫荧光分析。中周(middle turn)代表整个感觉上皮。图1A-图1C中的数据显示毛细胞和支持细胞中都有清晰的GFP表达，所述支持细胞包括以下支持细胞亚型：亨森氏细胞(HC)、Claudius细胞(CC)、Dieter细胞(DC)、内和外柱细胞(OPC/IPC)、内边界细胞和内指细胞(IPHC/IBC)。这些数据证明了Anc80-GFP AAV载体成功地转导到内耳感觉上皮的不同细胞类型中，以及由此得到的编码的报告基因(GFP)在这些不同细胞类型中的表达。这些数据表明，包含单一AAV载体或者两种或更多种AAV载体的本发明要求保护的组合物可用于在毛细胞和支持细胞中表达基因，并且可用于修复毛细胞和支持细胞中的基因突变。
其它实施方案
应当理解，尽管已经结合本发明的详细描述来描述了本发明，但前述描述意图进行说明而不是限制本发明的范围，本发明的范围由所附权利要求的范围限定。其它方面、有利方面和修改在所附权利要求的范围内。
本文提及的所有公布、专利申请、专利和其它参考文献通过引用以其整体并入本文。在有冲突的情况下，将以本说明书(包括定义)为准。另外，部分的标题、材料、方法和实例仅是说明性的而不是意图进行限制。

Claims (87)

1.一种包含至少两种不同的核酸载体的组合物，其中：
所述至少两种不同的腺相关病毒(AAV)载体中的每一种都包含编码序列，所述编码序列编码支持细胞靶蛋白的不同部分，所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；
所述至少两种不同的载体中单一载体均不编码全长支持细胞靶蛋白；
所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺少内含子序列；以及
所述至少两种不同的载体，当被引入到灵长类动物细胞中时，经历彼此串联或同源重组，从而形成编码全长支持细胞靶蛋白的重组核酸。
2.如权利要求1所述的组合物，其中所述编码的部分之一的氨基酸序列与所述编码的部分中的不同的一个部分的氨基酸序列重叠。
3.如权利要求2所述的组合物，其中所述编码的部分中的每一个的氨基酸序列与不同的编码的部分的氨基酸序列部分地重叠。
4.如权利要求2所述的组合物，其中所述重叠氨基酸序列的长度为30个氨基酸残基至约390个氨基酸残基。
5.如权利要求1-4中任一项所述的组合物，其中所述至少两种不同的载体中的每一种包含内含子的不同区段，其中所述内含子包含存在于支持细胞靶基因组DNA中的内含子的核苷酸序列，并且其中所述两个不同的区段在序列上重叠至少100个核苷酸。
6.如权利要求5所述的组合物，其中所述两个不同的区段在序列上重叠约30个核苷酸至约390个核苷酸。
7.如权利要求1-6中任一项所述的组合物，其中所述至少两种不同的载体中的每一种的核苷酸序列的长度为约30个核苷酸至约390个核苷酸。
8.如权利要求7中所述的组合物，其中所述至少两种不同的载体中的每一种的核苷酸序列的长度为30个核苷酸至340个核苷酸。
9.如权利要求1-8中任一项所述的组合物，其中所述组合物中不同载体的数目为2。
10.如权利要求9所述的组合物，其中所述两种不同的载体中的第一载体包含编码所述支持细胞靶蛋白的N末端部分的编码序列。
11.如权利要求10所述的组合物，其中所述支持细胞靶蛋白的N-末端部分的长度为约30个氨基酸至约390个氨基酸。
12.如权利要求11所述的组合物，其中所述支持细胞靶蛋白的N-末端部分的长度为约30个氨基酸至约340个氨基酸。
13.如权利要求10-12中任一项所述的组合物，其中所述第一载体还包含启动子和Kozak序列之一者或两者。
14.如权利要求13所述的方法，其中所述第一载体包含启动子，所述启动子为诱导型启动子、组成型启动子或组织特异性启动子。
15.如权利要求10-14中任一项所述的组合物，其中所述两种不同的载体中的第二载体包含编码所述支持细胞靶蛋白的C末端部分的编码序列。
16.如权利要求15所述的组合物，其中所述支持细胞靶蛋白的C-末端部分的长度为约30个氨基酸至约390个氨基酸。
17.如权利要求16所述的组合物，其中所述支持细胞靶蛋白的C-末端部分的长度为约30个氨基酸至约340个氨基酸。
18.如权利要求15-17中任一项所述的组合物，其中所述第二载体还包含poly(dA)序列。
19.一种包含两种不同的核酸载体的组合物，其中：
所述两种不同的核酸载体中的第一核酸载体包含启动子、位于所述启动子3’的编码支持细胞靶蛋白的N末端部分的第一编码序列和位于所述第一编码序列的3’末端的剪接供体信号序列；以及
所述两种不同的核酸载体中的第二核酸载体包含剪接受体信号序列、位于所述剪接受体信号序列的3'末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多聚腺苷酸化序列；
其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的氨基酸序列不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。
20.如权利要求19所述的组合物，其中所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述相邻外显子之间缺乏内含子序列。
21.一种组合物，其包含：
第一核酸载体，其包含启动子、位于所述启动子的3'的编码支持细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列，和位于所述剪接供体信号序列的3’的第一可检测标记基因；以及
第二核酸载体，其与所述第一核酸载体不同，包含第二可检测标记基因、位于所述第二可检测标记基因的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；
其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。
22.如权利要求21所述的组合物，其中所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述相邻外显子之间缺乏内含子序列。
23.如权利要求21所述的组合物，其中所述第一可检测标记基因或所述第二可检测标记基因是碱性磷酸酶。
24.如权利要求21或23所述的组合物，其中所述第一可检测标记基因和所述第二可检测标记基因是相同的。
25.一种组合物，其包含：
第一核酸载体，其包含启动子、位于所述启动子的3’的编码支持细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列和位于所述剪接供体信号序列的3’的F1噬菌体重组发生区；和
第二核酸载体，其与所述第一核酸载体不同，包含第二F1噬菌体重组发生区、位于所述第二F1噬菌体重组发生区的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码支持细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多聚腺苷酸化序列；
其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长支持细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号与另一个转录物上的所述剪接受体信号之间发生剪接，从而形成编码全长支持细胞靶蛋白的重组RNA分子。
26.如权利要求25所述的组合物，其中所述编码序列中的至少一个包含跨越支持细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列。
27.一种包含单一腺相关病毒(AAV)载体的组合物，其中所述单一AAV载体包含编码支持细胞靶蛋白的核酸序列；以及
当被引入到灵长类动物细胞中时，在支持细胞靶基因的基因座处产生编码全长支持细胞靶蛋白的核酸，并且所述灵长类动物表达所述支持细胞靶蛋白。
28.如权利要求1-27中任一项所述的组合物，其中所述支持细胞靶基因是缝隙连接蛋白β2(GJB2)。
29.如权利要求1-27中任一项所述的组合物，其中所述支持细胞靶基因是溶质运载蛋白家族26成员4(SLC26A4)。
30.一种包含至少两种不同的核酸载体的组合物，其中：
所述至少两种不同腺相关病毒(AAV)载体中的每一种都包含编码毛细胞靶蛋白的不同部分的编码序列，所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分中的每一个的氨基酸序列可以任选地与所述编码的部分中的不同的一个部分的氨基酸序列部分地重叠；
所述至少两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白；
所述编码序列中的至少一个包含跨越所述毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列；以及
所述至少两种不同的载体当被引入所述灵长类动物细胞时，经历彼此串联或同源重组，从而形成编码全长毛细胞靶蛋白的重组核酸。
31.如权利要求30所述的组合物，其中所述编码的部分中的一个的氨基酸序列与所述编码的部分中的不同的一个部分的氨基酸序列重叠。
32.如权利要求31所述的组合物，其中所述编码的部分中的每一个的氨基酸序列与不同的编码的部分的氨基酸序列部分地重叠。
33.如权利要求31所述的组合物，其中所述重叠的氨基酸序列的长度为30个氨基酸残基至约390个氨基酸残基。
34.如权利要求30-33中任一项所述的组合物，其中所述至少两种不同的载体中的每一种包含内含子的不同区段，其中所述内含子包含存在于毛细胞靶基因组DNA中的内含子的核苷酸序列，并且其中所述两个不同区段在序列上重叠至少100个核苷酸。
35.如权利要求34所述的组合物，其中所述两个不同的区段在序列上重叠约30个核苷酸至约390个核苷酸。
36.如权利要求30-35中任一项所述的组合物，其中所述至少两种不同的载体中的每一种的核苷酸序列的长度为约30个核苷酸至约390个核苷酸。
37.如权利要求36所述的组合物，其中所述至少两种不同的载体中的每一种的核苷酸序列的长度为30个核苷酸至340个核苷酸。
38.如权利要求30-37中任一项所述的组合物，其中所述组合物中不同载体的数量为2。
39.如权利要求38所述的组合物，其中所述两种不同的载体中的第一载体包含编码所述毛细胞靶蛋白的N末端部分的编码序列。
40.如权利要求39所述的组合物，其中所述毛细胞靶蛋白的N末端部分的长度为约30个氨基酸至约390个氨基酸。
41.如权利要求40所述的组合物，其中所述毛细胞靶蛋白的N末端部分的长度为约30个氨基酸至约340个氨基酸。
42.如权利要求39-41中任一项所述的组合物，其中所述第一载体还包含启动子和Kozak序列之一者或两者。
43.如权利要求42所述的组合物，其中所述第一载体包含启动子，所述启动子为诱导型启动子、组成型启动子或组织特异性启动子。
44.如权利要求39-41中任一项所述的组合物，其中所述两种不同的载体中的所述第二载体包含编码所述毛细胞靶蛋白的C末端部分的编码序列。
45.如权利要求44所述的组合物，其中所述毛细胞靶蛋白的C末端部分的长度为30个氨基酸至约390个氨基酸。
46.如权利要求45所述的组合物，其中所述毛细胞靶蛋白的C末端部分的长度为30个氨基酸至约340个氨基酸。
47.如权利要求44-46中任一项所述的组合物，其中所述第二载体还包含poly(dA)序列。
48.一种包含两种不同的核酸载体的组合物，其中：
所述两种不同的核酸载体中的第一核酸载体包含启动子、位于所述启动子的3’的编码毛细胞靶蛋白的N末端部分的第一编码序列和位于所述第一编码序列的3’末端的剪接供体信号序列；以及
所述两种不同的核酸载体中的第二核酸载体包含剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；
其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的氨基酸序列不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。
49.如权利要求48所述的组合物，其中所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述相邻外显子之间缺乏内含子序列。
50.一种组合物，其包含：
第一核酸载体，其包含启动子、位于所述启动子的3’的编码毛细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列和位于所述剪接供体信号序列的3’的第一可检测标记基因；和
第二核酸载体，其与所述第一核酸载体不同，包含第二可检测标记基因、位于所述第二可检测标记基因的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；
其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。
51.如权利要求50所述的组合物，其中所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述相邻外显子之间缺乏内含子序列。
52.如权利要求50所述的组合物，其中所述第一可检测标记基因或所述第二可检测标记基因是碱性磷酸酶。
53.如权利要求50或52所述的组合物，其中所述第一可检测标记基因和所述第二可检测标记基因是相同的。
54.一种组合物，其包含：
第一核酸载体，其包含启动子、位于所述启动子的3’的编码毛细胞靶蛋白的N末端部分的第一编码序列、位于所述第一编码序列的3’末端的剪接供体信号序列和位于所述剪接供体信号序列的3’的F1噬菌体重组发生区；和
第二核酸载体，其与所述第一核酸载体不同，包含第二F1噬菌体重组发生区、位于所述第二F1噬菌体重组发生区的3’的剪接受体信号序列、位于所述剪接受体信号序列的3’末端的编码毛细胞靶蛋白的C末端部分的第二编码序列和位于所述第二编码序列的3’末端的多腺苷酸化序列；
其中所述编码的部分中的每一个的长度至少为30个氨基酸残基，其中所述编码的部分的各自的氨基酸序列彼此不重叠，其中所述两种不同的载体中单一载体均不编码所述全长毛细胞靶蛋白，并且当所述编码序列在灵长类动物细胞中转录以产生RNA转录物时，在一个转录物上的所述剪接供体信号序列与另一个转录物上的所述剪接受体信号序列之间发生剪接，从而形成编码全长毛细胞靶蛋白的重组RNA分子。
55.如权利要求54所述的组合物，其中所述编码序列中的至少一个包含跨越毛细胞靶基因组DNA的两个相邻外显子的核苷酸序列，并且在所述两个相邻外显子之间缺乏内含子序列。
56.如权利要求30-55中任一项所述的组合物，其中所述毛细胞靶基因是OTOF基因、TRIOBP基因或STRC基因。
57.一种包含单一腺相关病毒(AAV)载体的组合物，其中所述单一AAV载体包含编码毛细胞靶蛋白的核酸序列；以及
当被引入到灵长类动物细胞时，在所述毛细胞靶基因的基因座处产生编码全长毛细胞靶蛋白的核酸，并且所述灵长类动物表达所述毛细胞靶蛋白。
58.如权利要求57所述的组合物，其中所述毛细胞靶基因是PJVK基因、OTOF基因、NDP基因、CLRN1基因、TRIOBP基因、STRC基因、TMC1基因、VEGF基因或HSPA1A基因。
59.如权利要求1-58中任一项所述的药物组合物，所述药物组合物还包含药学上可接受的赋形剂。
60.一种试剂盒，其包含权利要求1-59中任一项所述的组合物。
61.如权利要求60所述的试剂盒，所述试剂盒还包括包含所述组合物的预装式注射器。
62.一种校正灵长类动物内耳的支持细胞中的支持细胞靶基因缺陷的方法，所述方法包括：
向所述灵长类动物的内耳施用治疗有效量的权利要求1-29中任一项所述的组合物，
其中所述施用修复所述灵长类动物内耳的支持细胞中的支持细胞靶基因缺陷。
63.一种升高灵长类动物内耳的支持细胞中的支持细胞靶蛋白的表达水平的方法，所述方法包括向所述灵长类动物的内耳施用治疗有效量的权利要求1至29中任一项所述的组合物，
其中所述施用使得所述灵长类动物内耳的所述支持细胞中的所述支持细胞靶蛋白的表达水平升高。
64.如权利要求63所述的方法，其中所述灵长类动物先前已被确定具有缺陷型支持细胞靶基因。
65.一种治疗被鉴定为具有缺陷型支持细胞靶基因的灵长类动物的非综合征性感音神经性听力损失的方法，所述方法包括：
向所述灵长类动物的内耳施用治疗有效量的权利要求1-29中任一项所述的组合物。
66.如权利要求65所述的方法，所述方法还包括在所述施用步骤之前，确定所述灵长类动物具有缺陷型支持细胞靶基因。
67.一种恢复被鉴定或诊断为患有听力损失的灵长类动物的听力的方法，所述方法包括：
向所述灵长类动物的内耳施用治疗有效量的权利要求1-29中任一项所述的组合物。
68.如权利要求67所述的方法，所述方法还包括在所述施用步骤之前，确定所述灵长类动物具有缺陷型支持细胞靶基因。
69.一种恢复被鉴定或诊断为患有内耳病症的灵长类动物的突触并且/或者保留其螺旋神经节神经的方法，所述方法包括：
向所述灵长类动物的内耳施用治疗有效量的权利要求1-29中任一项所述的组合物。
70.如权利要求69所述的方法，所述方法还包括在所述施用步骤之前，确定所述灵长类动物具有缺陷型支持细胞靶基因。
71.一种方法，所述方法包括向灵长类动物的内耳施用治疗有效量的权利要求1-29中任一项所述的组合物。
72.如权利要求71所述的方法，其中所述灵长类动物先前已被鉴定为具有缺陷型支持细胞靶基因。
73.一种校正灵长类动物内耳的毛细胞中的毛细胞靶基因缺陷的方法，所述方法包括：
向所述灵长类动物的内耳施用治疗有效量的权利要求30-59中任一项所述的组合物，
其中所述施用修复所述灵长类动物内耳的毛细胞中的所述毛细胞靶基因缺陷。
74.一种升高灵长类动物内耳的毛细胞中的毛细胞靶蛋白的表达水平的方法，所述方法包括向所述灵长类动物的内耳施用治疗有效量的权利要求30-59中任一项所述的组合物，
其中所述施用使得所述灵长类动物内耳的毛细胞中的所述毛细胞靶蛋白的表达水平升高。
75.如权利要求74所述的方法，其中所述灵长类动物先前已被确定具有缺陷型毛细胞靶基因。
76.一种治疗被鉴定为具有缺陷型毛细胞靶基因的灵长类动物的非综合征性感音神经性听力损失的方法，所述方法包括：
向所述灵长类动物的内耳施用治疗有效量的权利要求30-59中任一项所述的组合物。
77.如权利要求76所述的方法，所述方法还包括在所述施用步骤之前，确定所述灵长类动物具有缺陷型毛细胞靶基因。
78.一种恢复被鉴定或诊断为患有听力损失的灵长类动物的听力的方法，所述方法包括：
向所述灵长类动物的内耳施用治疗有效量的权利要求30-59中任一项所述的组合物。
79.如权利要求78所述的方法，所述方法还包括，在所述施用步骤之前，确定所述灵长类动物具有缺陷型毛细胞靶基因。
80.一种恢复被鉴定或诊断为患有内耳病症的灵长类动物的突触并且/或者保留其螺旋神经节神经的方法，所述方法包括：
向所述灵长类动物的内耳施用治疗有效量的权利要求30-59中任一项所述的组合物。
81.如权利要求80所述的方法，所述方法还包括，在所述施用步骤之前，确定所述灵长类动物具有缺陷型毛细胞靶基因。
82.一种方法，所述方法包括向灵长类动物的内耳施用治疗有效量的权利要求30-59中任一项所述的组合物。
83.如权利要求82所述的方法，其中所述灵长类动物先前已被鉴定为具有缺陷型毛细胞靶基因。
84.如权利要求1-26或30-56中任一项所述的组合物，其中所述第二核酸载体还包含去稳定序列。
85.如权利要求84所述的组合物，其中所述第二核酸载体还包含FKBP12去稳定序列。
86.如权利要求27-29或57-59中任一项所述的组合物，其中所述核酸载体还包含去稳定序列。
87.如权利要求86所述的组合物，其中所述核酸载体包含FKBP12去稳定序列。
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