JP2016526924A5 - - Google Patents
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- Publication number
- JP2016526924A5 JP2016526924A5 JP2016533448A JP2016533448A JP2016526924A5 JP 2016526924 A5 JP2016526924 A5 JP 2016526924A5 JP 2016533448 A JP2016533448 A JP 2016533448A JP 2016533448 A JP2016533448 A JP 2016533448A JP 2016526924 A5 JP2016526924 A5 JP 2016526924A5
- Authority
- JP
- Japan
- Prior art keywords
- locus
- human animal
- exon
- lncrna
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091046869 Telomeric non-coding RNA Proteins 0.000 claims description 84
- 150000007523 nucleic acids Chemical class 0.000 claims description 62
- 108020004707 nucleic acids Proteins 0.000 claims description 47
- 102000039446 nucleic acids Human genes 0.000 claims description 47
- 108700024394 Exon Proteins 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 24
- 108091007460 Long intergenic noncoding RNA Proteins 0.000 claims description 21
- 230000014509 gene expression Effects 0.000 claims description 20
- 238000012217 deletion Methods 0.000 claims description 19
- 230000037430 deletion Effects 0.000 claims description 19
- 230000008685 targeting Effects 0.000 claims description 16
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 15
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 12
- 108091026890 Coding region Proteins 0.000 claims description 12
- 239000002773 nucleotide Substances 0.000 claims description 12
- 125000003729 nucleotide group Chemical group 0.000 claims description 12
- 108091092889 HOTTIP Proteins 0.000 claims description 11
- 230000007547 defect Effects 0.000 claims description 9
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims description 8
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims description 8
- 108010082025 cyan fluorescent protein Proteins 0.000 claims description 8
- 108010048367 enhanced green fluorescent protein Proteins 0.000 claims description 8
- 108010021843 fluorescent protein 583 Proteins 0.000 claims description 8
- 238000012239 gene modification Methods 0.000 claims description 8
- 239000005090 green fluorescent protein Substances 0.000 claims description 8
- 230000006801 homologous recombination Effects 0.000 claims description 8
- 238000002744 homologous recombination Methods 0.000 claims description 8
- 210000001161 mammalian embryo Anatomy 0.000 claims description 8
- 239000003550 marker Substances 0.000 claims description 8
- 210000003205 muscle Anatomy 0.000 claims description 7
- 108091023288 HOTAIR Proteins 0.000 claims description 6
- 206010063493 Premature ageing Diseases 0.000 claims description 6
- 208000032038 Premature aging Diseases 0.000 claims description 6
- 230000005017 genetic modification Effects 0.000 claims description 6
- 235000013617 genetically modified food Nutrition 0.000 claims description 6
- 108700023707 TUG1 Proteins 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 210000001519 tissue Anatomy 0.000 claims description 5
- YMHOBZXQZVXHBM-UHFFFAOYSA-N 2,5-dimethoxy-4-bromophenethylamine Chemical compound COC1=CC(CCN)=C(OC)C=C1Br YMHOBZXQZVXHBM-UHFFFAOYSA-N 0.000 claims description 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims description 4
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims description 4
- 108091005944 Cerulean Proteins 0.000 claims description 4
- 241000579895 Chlorostilbon Species 0.000 claims description 4
- 108091035707 Consensus sequence Proteins 0.000 claims description 4
- 108091005943 CyPet Proteins 0.000 claims description 4
- 108060001084 Luciferase Proteins 0.000 claims description 4
- 239000005089 Luciferase Substances 0.000 claims description 4
- 241000545067 Venus Species 0.000 claims description 4
- 108010005774 beta-Galactosidase Proteins 0.000 claims description 4
- 102000005936 beta-Galactosidase Human genes 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 230000007423 decrease Effects 0.000 claims description 4
- 229910052876 emerald Inorganic materials 0.000 claims description 4
- 239000010976 emerald Substances 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 230000006798 recombination Effects 0.000 claims description 4
- 238000005215 recombination Methods 0.000 claims description 4
- 108010054624 red fluorescent protein Proteins 0.000 claims description 4
- 229910052594 sapphire Inorganic materials 0.000 claims description 4
- 239000010980 sapphire Substances 0.000 claims description 4
- 206010003694 Atrophy Diseases 0.000 claims description 3
- 208000000875 Spinal Curvatures Diseases 0.000 claims description 3
- 210000000577 adipose tissue Anatomy 0.000 claims description 3
- 230000037444 atrophy Effects 0.000 claims description 3
- 210000000988 bone and bone Anatomy 0.000 claims description 3
- 230000004641 brain development Effects 0.000 claims description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
- 231100000225 lethality Toxicity 0.000 claims description 3
- 239000011707 mineral Substances 0.000 claims description 3
- 210000000056 organ Anatomy 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 2
- 241000283984 Rodentia Species 0.000 claims description 2
- 230000032683 aging Effects 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 230000003247 decreasing effect Effects 0.000 claims description 2
- 230000007040 lung development Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000000877 morphologic effect Effects 0.000 claims description 2
- 230000009984 peri-natal effect Effects 0.000 claims description 2
- 210000000689 upper leg Anatomy 0.000 claims description 2
- 108700008625 Reporter Genes Proteins 0.000 claims 7
- 230000001747 exhibiting effect Effects 0.000 claims 6
- 210000004556 brain Anatomy 0.000 claims 4
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000010428 Muscle Weakness Diseases 0.000 claims 1
- 206010028372 Muscular weakness Diseases 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 230000013020 embryo development Effects 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 230000007849 functional defect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 231100000518 lethal Toxicity 0.000 claims 1
- 230000001665 lethal effect Effects 0.000 claims 1
- 230000002123 temporal effect Effects 0.000 claims 1
- 241000124008 Mammalia Species 0.000 description 3
- 230000004777 loss-of-function mutation Effects 0.000 description 2
- 241000699800 Cricetinae Species 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361863147P | 2013-08-07 | 2013-08-07 | |
| US61/863,147 | 2013-08-07 | ||
| PCT/US2014/050178 WO2015021298A2 (en) | 2013-08-07 | 2014-08-07 | Lincrna-deficient non-human animals |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017037511A Division JP6192865B2 (ja) | 2013-08-07 | 2017-02-28 | ｌｉｎｃＲＮＡ欠失非ヒト動物 |
| JP2018235716A Division JP2019037253A (ja) | 2013-08-07 | 2018-12-17 | ｌｉｎｃＲＮＡ欠失非ヒト動物 |
| JP2020070279A Division JP2020108409A (ja) | 2013-08-07 | 2020-04-09 | ｌｉｎｃＲＮＡ欠失非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016526924A JP2016526924A (ja) | 2016-09-08 |
| JP2016526924A5 true JP2016526924A5 (enExample) | 2017-09-14 |
| JP6998656B2 JP6998656B2 (ja) | 2022-02-04 |
Family
ID=52449819
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533448A Active JP6998656B2 (ja) | 2013-08-07 | 2014-08-07 | ｌｉｎｃＲＮＡ欠失非ヒト動物 |
| JP2017037511A Active JP6192865B2 (ja) | 2013-08-07 | 2017-02-28 | ｌｉｎｃＲＮＡ欠失非ヒト動物 |
| JP2018235716A Withdrawn JP2019037253A (ja) | 2013-08-07 | 2018-12-17 | ｌｉｎｃＲＮＡ欠失非ヒト動物 |
| JP2020070279A Pending JP2020108409A (ja) | 2013-08-07 | 2020-04-09 | ｌｉｎｃＲＮＡ欠失非ヒト動物 |
| JP2022109170A Withdrawn JP2022125255A (ja) | 2013-08-07 | 2022-07-06 | ｌｉｎｃＲＮＡ欠失非ヒト動物 |
| JP2024146626A Pending JP2024164230A (ja) | 2013-08-07 | 2024-08-28 | ｌｉｎｃＲＮＡ欠失非ヒト動物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017037511A Active JP6192865B2 (ja) | 2013-08-07 | 2017-02-28 | ｌｉｎｃＲＮＡ欠失非ヒト動物 |
| JP2018235716A Withdrawn JP2019037253A (ja) | 2013-08-07 | 2018-12-17 | ｌｉｎｃＲＮＡ欠失非ヒト動物 |
| JP2020070279A Pending JP2020108409A (ja) | 2013-08-07 | 2020-04-09 | ｌｉｎｃＲＮＡ欠失非ヒト動物 |
| JP2022109170A Withdrawn JP2022125255A (ja) | 2013-08-07 | 2022-07-06 | ｌｉｎｃＲＮＡ欠失非ヒト動物 |
| JP2024146626A Pending JP2024164230A (ja) | 2013-08-07 | 2024-08-28 | ｌｉｎｃＲＮＡ欠失非ヒト動物 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9554564B2 (enExample) |
| EP (2) | EP3030653A4 (enExample) |
| JP (6) | JP6998656B2 (enExample) |
| KR (3) | KR102138723B1 (enExample) |
| CN (2) | CN105518132B (enExample) |
| AU (3) | AU2014305873B2 (enExample) |
| BR (1) | BR112016002385A2 (enExample) |
| CA (1) | CA2917714A1 (enExample) |
| DK (1) | DK3178928T3 (enExample) |
| ES (1) | ES2812242T3 (enExample) |
| HK (1) | HK1220990A1 (enExample) |
| IL (2) | IL294443A (enExample) |
| MX (3) | MX369452B (enExample) |
| MY (2) | MY182065A (enExample) |
| NZ (1) | NZ716168A (enExample) |
| RU (1) | RU2721855C2 (enExample) |
| SG (2) | SG10201803766UA (enExample) |
| WO (1) | WO2015021298A2 (enExample) |
| ZA (1) | ZA201600170B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2019125818A (ru) | 2017-02-27 | 2021-03-29 | Регенерон Фармасьютикалс, Инк. | Модели ретиношизиса на животных, отличных от человека |
| WO2019018410A1 (en) * | 2017-07-17 | 2019-01-24 | The General Hospital Corporation | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASES |
| WO2019058253A1 (en) | 2017-09-19 | 2019-03-28 | Tropic Biosciences UK Limited | MODIFICATION OF THE SPECIFICITY OF NON-CODING RNA MOLECULES FOR SILENCING GENE EXPRESSION IN EUKARYOTIC CELLS |
| US11932858B2 (en) | 2017-12-14 | 2024-03-19 | Donald Danforth Plant Science Center | Homologous recombination via transcriptional activation |
| CN108728545A (zh) * | 2018-06-25 | 2018-11-02 | 汕头大学医学院附属肿瘤医院 | 结直肠癌长链非编码rna-hotair分子标志物及其应用 |
| CN108950001B (zh) * | 2018-08-31 | 2020-08-11 | 青岛泱深生物医药有限公司 | 一种与直肠腺癌发生发展相关的分子标志物 |
| CN108866198B (zh) * | 2018-08-31 | 2020-08-11 | 青岛泱深生物医药有限公司 | 标志物loc105376380在直肠腺癌诊断和治疗中的应用 |
| CN108950000B (zh) * | 2018-08-31 | 2020-08-04 | 青岛泱深生物医药有限公司 | lncRNA在直肠腺癌诊疗中的应用 |
| CN111218451B (zh) * | 2020-02-05 | 2021-08-10 | 华中农业大学 | 一种提高猪肌肉量的方法 |
| RU2752663C1 (ru) * | 2020-05-18 | 2021-07-29 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "СберМедИИ" | Способ квантификации статистического анализа альтернативного сплайсинга в данных рнк-сек |
| WO2022138421A1 (ja) * | 2020-12-22 | 2022-06-30 | 公立大学法人大阪 | Ｘ染色体ノックインモデル動物 |
| USD1010297S1 (en) * | 2021-06-30 | 2024-01-09 | Puma SE | Shoe |
| CN113999873B (zh) * | 2021-12-31 | 2022-05-20 | 北京市疾病预防控制中心 | 一种基因修饰的非人动物的构建方法及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| AU2005295269B2 (en) | 2004-10-19 | 2010-05-13 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
| CN101619312B (zh) | 2009-07-10 | 2011-04-20 | 四川大学 | 人黑色素瘤细胞特异表达的长非编码rna序列及其用途 |
| CN101633923B (zh) * | 2009-07-10 | 2011-04-13 | 四川大学 | 人黑色素瘤细胞相关的长非编码rna及其用途 |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| WO2011020014A1 (en) | 2009-08-14 | 2011-02-17 | Regeneron Pharmaceuticals, Inc. | Promoter-regulated differentiation-dependent self-deleting cassette |
| WO2011059799A1 (en) | 2009-10-29 | 2011-05-19 | Regeneron Pharmaceuticals, Inc. | Multifunctional alleles |
| US20120004278A1 (en) | 2010-06-18 | 2012-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Linc rnas in cancer diagnosis and treatment |
| WO2012018881A2 (en) | 2010-08-03 | 2012-02-09 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for the regulation of rna |
| WO2013134558A1 (en) | 2012-03-07 | 2013-09-12 | The Texas A & M University System | Cancer treatment targeting non-coding rna overexpression |
| AU2014218931C1 (en) | 2013-02-20 | 2020-05-14 | Regeneron Pharmaceuticals, Inc. | Genetic modification of rats |
| CA2908697C (en) | 2013-04-16 | 2023-12-12 | Regeneron Pharmaceuticals, Inc. | Targeted modification of rat genome |
| RU2744831C2 (ru) * | 2015-03-16 | 2021-03-16 | Регенерон Фармасьютикалз, Инк. | Не относящееся к человеку животное, у которого проявляется снижение функции верхних и нижних моторных нейронов и чувственного восприятия |
-
2014
- 2014-08-07 CN CN201480042722.1A patent/CN105518132B/zh active Active
- 2014-08-07 RU RU2016107434A patent/RU2721855C2/ru active
- 2014-08-07 BR BR112016002385A patent/BR112016002385A2/pt not_active Application Discontinuation
- 2014-08-07 IL IL294443A patent/IL294443A/en unknown
- 2014-08-07 CN CN202110062319.7A patent/CN112715485A/zh active Pending
- 2014-08-07 NZ NZ716168A patent/NZ716168A/en unknown
- 2014-08-07 MY MYPI2016700017A patent/MY182065A/en unknown
- 2014-08-07 KR KR1020167002367A patent/KR102138723B1/ko active Active
- 2014-08-07 HK HK16109080.4A patent/HK1220990A1/zh unknown
- 2014-08-07 KR KR1020177001244A patent/KR101853466B1/ko not_active Expired - Fee Related
- 2014-08-07 ES ES17152034T patent/ES2812242T3/es active Active
- 2014-08-07 EP EP14834544.0A patent/EP3030653A4/en not_active Withdrawn
- 2014-08-07 EP EP17152034.9A patent/EP3178928B1/en active Active
- 2014-08-07 IL IL243581A patent/IL243581B/en unknown
- 2014-08-07 WO PCT/US2014/050178 patent/WO2015021298A2/en not_active Ceased
- 2014-08-07 AU AU2014305873A patent/AU2014305873B2/en not_active Ceased
- 2014-08-07 CA CA2917714A patent/CA2917714A1/en active Pending
- 2014-08-07 JP JP2016533448A patent/JP6998656B2/ja active Active
- 2014-08-07 DK DK17152034.9T patent/DK3178928T3/da active
- 2014-08-07 MX MX2016001682A patent/MX369452B/es active IP Right Grant
- 2014-08-07 KR KR1020207021344A patent/KR102350200B1/ko not_active Expired - Fee Related
- 2014-08-07 SG SG10201803766UA patent/SG10201803766UA/en unknown
- 2014-08-07 MY MYPI2018702265A patent/MY198884A/en unknown
- 2014-08-07 SG SG11201600036QA patent/SG11201600036QA/en unknown
- 2014-08-07 US US14/454,464 patent/US9554564B2/en active Active
-
2016
- 2016-01-08 ZA ZA2016/00170A patent/ZA201600170B/en unknown
- 2016-02-05 MX MX2019013309A patent/MX2019013309A/es unknown
- 2016-02-05 MX MX2022013409A patent/MX2022013409A/es unknown
- 2016-11-30 US US15/365,250 patent/US11547100B2/en active Active
-
2017
- 2017-01-11 AU AU2017200183A patent/AU2017200183C1/en not_active Ceased
- 2017-02-28 JP JP2017037511A patent/JP6192865B2/ja active Active
-
2018
- 2018-01-12 AU AU2018200281A patent/AU2018200281B2/en not_active Ceased
- 2018-12-17 JP JP2018235716A patent/JP2019037253A/ja not_active Withdrawn
-
2020
- 2020-04-09 JP JP2020070279A patent/JP2020108409A/ja active Pending
-
2022
- 2022-07-06 JP JP2022109170A patent/JP2022125255A/ja not_active Withdrawn
- 2022-11-16 US US18/056,118 patent/US20230189771A1/en active Pending
-
2024
- 2024-08-28 JP JP2024146626A patent/JP2024164230A/ja active Pending
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