MX369452B - Animales no humanos deficientes en lncrna. - Google Patents

Animales no humanos deficientes en lncrna.

Info

Publication number
MX369452B
MX369452B MX2016001682A MX2016001682A MX369452B MX 369452 B MX369452 B MX 369452B MX 2016001682 A MX2016001682 A MX 2016001682A MX 2016001682 A MX2016001682 A MX 2016001682A MX 369452 B MX369452 B MX 369452B
Authority
MX
Mexico
Prior art keywords
genetically modified
lncrnas
human animals
methods
compositions
Prior art date
Application number
MX2016001682A
Other languages
English (en)
Other versions
MX2016001682A (es
Inventor
Frendewey David
M Valenzuela David
Gong Guochun
RINN John
Man Venus Lai Ka-
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2016001682A publication Critical patent/MX2016001682A/es
Publication of MX369452B publication Critical patent/MX369452B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A01K2217/077—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out heterozygous knock out animals displaying phenotype
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Abstract

La presente invención se refiere a animales no humanos modificados genéticamente que exhiben una carencia funcional de uno o varios IncRNA. Se proporcionan métodos y composiciones para alterar, suprimir y/o reemplazar secuencias que codifican IncRNA. Se proporcionan ratones modificados genéticamente que envejecen prematuramente. También se proporcionan células, tejidos y embriones que están modificados genéticamente para comprender una pérdida de función de uno o varios IncRNA.
MX2016001682A 2013-08-07 2014-08-07 Animales no humanos deficientes en lncrna. MX369452B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361863147P 2013-08-07 2013-08-07
PCT/US2014/050178 WO2015021298A2 (en) 2013-08-07 2014-08-07 Lincrna-deficient non-human animals

Publications (2)

Publication Number Publication Date
MX2016001682A MX2016001682A (es) 2017-04-13
MX369452B true MX369452B (es) 2019-11-08

Family

ID=52449819

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2016001682A MX369452B (es) 2013-08-07 2014-08-07 Animales no humanos deficientes en lncrna.
MX2022013409A MX2022013409A (es) 2013-08-07 2016-02-05 Animales no humanos deficientes en lincrna.
MX2019013309A MX2019013309A (es) 2013-08-07 2016-02-05 Animales no humanos deficientes en lncrna.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2022013409A MX2022013409A (es) 2013-08-07 2016-02-05 Animales no humanos deficientes en lincrna.
MX2019013309A MX2019013309A (es) 2013-08-07 2016-02-05 Animales no humanos deficientes en lncrna.

Country Status (19)

Country Link
US (3) US9554564B2 (es)
EP (2) EP3178928B1 (es)
JP (5) JP6998656B2 (es)
KR (3) KR102350200B1 (es)
CN (2) CN105518132B (es)
AU (3) AU2014305873B2 (es)
BR (1) BR112016002385A2 (es)
CA (1) CA2917714A1 (es)
DK (1) DK3178928T3 (es)
ES (1) ES2812242T3 (es)
HK (1) HK1220990A1 (es)
IL (2) IL243581B (es)
MX (3) MX369452B (es)
MY (1) MY182065A (es)
NZ (1) NZ716168A (es)
RU (1) RU2721855C2 (es)
SG (2) SG10201803766UA (es)
WO (1) WO2015021298A2 (es)
ZA (1) ZA201600170B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020508073A (ja) * 2017-02-27 2020-03-19 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 網膜分離症の非ヒト動物モデル
WO2019018410A1 (en) * 2017-07-17 2019-01-24 The General Hospital Corporation COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY BOWEL DISEASES
WO2019058253A1 (en) 2017-09-19 2019-03-28 Tropic Biosciences UK Limited MODIFICATION OF THE SPECIFICITY OF NON-CODING RNA MOLECULES FOR SILENCING GENE EXPRESSION IN EUKARYOTIC CELLS
WO2019118879A1 (en) * 2017-12-14 2019-06-20 Donald Danforth Plant Science Center Homologous recombination via transcriptional activation
CN108728545A (zh) * 2018-06-25 2018-11-02 汕头大学医学院附属肿瘤医院 结直肠癌长链非编码rna-hotair分子标志物及其应用
CN108950001B (zh) * 2018-08-31 2020-08-11 青岛泱深生物医药有限公司 一种与直肠腺癌发生发展相关的分子标志物
CN108866198B (zh) * 2018-08-31 2020-08-11 青岛泱深生物医药有限公司 标志物loc105376380在直肠腺癌诊断和治疗中的应用
CN108950000B (zh) * 2018-08-31 2020-08-04 青岛泱深生物医药有限公司 lncRNA在直肠腺癌诊疗中的应用
CN111218451B (zh) * 2020-02-05 2021-08-10 华中农业大学 一种提高猪肌肉量的方法
RU2752663C1 (ru) * 2020-05-18 2021-07-29 ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "СберМедИИ" Способ квантификации статистического анализа альтернативного сплайсинга в данных рнк-сек
CN113999873B (zh) * 2021-12-31 2022-05-20 北京市疾病预防控制中心 一种基因修饰的非人动物的构建方法及其应用

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US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
AU2005295269B2 (en) 2004-10-19 2010-05-13 Regeneron Pharmaceuticals, Inc. Method for generating an animal homozygous for a genetic modification
CN101633923B (zh) * 2009-07-10 2011-04-13 四川大学 人黑色素瘤细胞相关的长非编码rna及其用途
CN101619312B (zh) * 2009-07-10 2011-04-20 四川大学 人黑色素瘤细胞特异表达的长非编码rna序列及其用途
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
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RU2744831C2 (ru) * 2015-03-16 2021-03-16 Регенерон Фармасьютикалз, Инк. Не относящееся к человеку животное, у которого проявляется снижение функции верхних и нижних моторных нейронов и чувственного восприятия

Also Published As

Publication number Publication date
EP3178928A1 (en) 2017-06-14
JP6998656B2 (ja) 2022-02-04
ZA201600170B (en) 2022-03-30
KR20200090977A (ko) 2020-07-29
HK1220990A1 (zh) 2017-05-19
US20150047062A1 (en) 2015-02-12
AU2017200183C1 (en) 2023-04-27
BR112016002385A2 (pt) 2017-09-12
US9554564B2 (en) 2017-01-31
WO2015021298A3 (en) 2015-04-02
RU2721855C2 (ru) 2020-05-25
DK3178928T3 (da) 2020-08-24
IL243581B (en) 2022-08-01
KR102350200B1 (ko) 2022-01-14
CN105518132A (zh) 2016-04-20
MX2019013309A (es) 2020-07-28
RU2016107434A (ru) 2017-09-15
IL294443A (en) 2022-09-01
MX2022013409A (es) 2022-11-14
KR20170012567A (ko) 2017-02-02
EP3178928B1 (en) 2020-06-10
KR101853466B1 (ko) 2018-04-30
AU2014305873A1 (en) 2016-02-04
KR20160035585A (ko) 2016-03-31
NZ716168A (en) 2022-05-27
MY182065A (en) 2021-01-18
IL243581A0 (en) 2016-03-31
AU2018200281A1 (en) 2018-02-01
EP3030653A2 (en) 2016-06-15
JP2022125255A (ja) 2022-08-26
KR102138723B1 (ko) 2020-07-29
US11547100B2 (en) 2023-01-10
MX2016001682A (es) 2017-04-13
JP2017099407A (ja) 2017-06-08
JP2016526924A (ja) 2016-09-08
WO2015021298A2 (en) 2015-02-12
AU2018200281B2 (en) 2020-10-08
EP3030653A4 (en) 2017-07-26
SG11201600036QA (en) 2016-02-26
AU2017200183B2 (en) 2018-02-01
JP2020108409A (ja) 2020-07-16
JP2019037253A (ja) 2019-03-14
ES2812242T3 (es) 2021-03-16
AU2017200183A1 (en) 2017-02-02
JP6192865B2 (ja) 2017-09-06
SG10201803766UA (en) 2018-06-28
US20230189771A1 (en) 2023-06-22
AU2014305873B2 (en) 2017-08-31
CN105518132B (zh) 2021-02-05
US20170071173A1 (en) 2017-03-16
CN112715485A (zh) 2021-04-30
CA2917714A1 (en) 2015-02-12

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