WO2015021263A3 - Methylation biomarkers for colorectal cancer - Google Patents

Methylation biomarkers for colorectal cancer Download PDF

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Publication number
WO2015021263A3
WO2015021263A3 PCT/US2014/050120 US2014050120W WO2015021263A3 WO 2015021263 A3 WO2015021263 A3 WO 2015021263A3 US 2014050120 W US2014050120 W US 2014050120W WO 2015021263 A3 WO2015021263 A3 WO 2015021263A3
Authority
WO
WIPO (PCT)
Prior art keywords
colorectal cancer
methylation biomarkers
diagnosis
subject
methylation
Prior art date
Application number
PCT/US2014/050120
Other languages
French (fr)
Other versions
WO2015021263A2 (en
Inventor
Carmen SAPIENZA
Matthew L. SILVIERA
Brian P. Smith
Rima Rozen
Daniel Leclerc
Original Assignee
Temple University-Of The Commonwealth System Of Higher Education
The Royal Institution For The Advancement Of Learning/Mcgill University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Temple University-Of The Commonwealth System Of Higher Education, The Royal Institution For The Advancement Of Learning/Mcgill University filed Critical Temple University-Of The Commonwealth System Of Higher Education
Publication of WO2015021263A2 publication Critical patent/WO2015021263A2/en
Publication of WO2015021263A3 publication Critical patent/WO2015021263A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides compositions and methods for the diagnosis of colorectal cancer in a subject. In one embodiment, the method includes detecting methylation status of one or more genes in a sample to diagnosis the subject. The invention further relates to DNA methylation as a predictor of disease recurrence and patient prognosis, specifically in the field of cancer biology.
PCT/US2014/050120 2013-08-08 2014-08-07 Methylation biomarkers for colorectal cancer WO2015021263A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361863682P 2013-08-08 2013-08-08
US61/863,682 2013-08-08
US201461975323P 2014-04-04 2014-04-04
US61/975,323 2014-04-04

Publications (2)

Publication Number Publication Date
WO2015021263A2 WO2015021263A2 (en) 2015-02-12
WO2015021263A3 true WO2015021263A3 (en) 2015-04-02

Family

ID=52462038

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/050120 WO2015021263A2 (en) 2013-08-08 2014-08-07 Methylation biomarkers for colorectal cancer

Country Status (1)

Country Link
WO (1) WO2015021263A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3692164A4 (en) * 2017-10-06 2021-09-29 Youhealth Oncotech, Limited Methylation markers for diagnosing cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050130172A1 (en) * 2003-12-16 2005-06-16 Bayer Corporation Identification and verification of methylation marker sequences
WO2013064163A1 (en) * 2011-11-01 2013-05-10 Academisch Medisch Centrum Methylation markers for colorectal cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050130172A1 (en) * 2003-12-16 2005-06-16 Bayer Corporation Identification and verification of methylation marker sequences
WO2013064163A1 (en) * 2011-11-01 2013-05-10 Academisch Medisch Centrum Methylation markers for colorectal cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BLOUIN ET AL.: "Butyrate Elicits a Metabolic Switch in Human Colon Cancer Cells by Targeting the Pyruvate Dehydrogenase Complex.", INT. J. CANCER., vol. 128, no. 11, June 2011 (2011-06-01), pages 2591 - 2601 *
LEE ET AL.: "Systematic Genomic Identification of Colorectal Cancer Genes Delineating Aadvanced From Early Clinical Stage and Metastasis.", BMC MED. GENOMICS, vol. 6, no. 54, December 2013 (2013-12-01), pages 1 - 15 *

Also Published As

Publication number Publication date
WO2015021263A2 (en) 2015-02-12

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