JP6998656B2 - ｌｉｎｃＲＮＡ欠失非ヒト動物 - Google Patents

ｌｉｎｃＲＮＡ欠失非ヒト動物 Download PDF

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JP6998656B2
JP6998656B2 JP2016533448A JP2016533448A JP6998656B2 JP 6998656 B2 JP6998656 B2 JP 6998656B2 JP 2016533448 A JP2016533448 A JP 2016533448A JP 2016533448 A JP2016533448 A JP 2016533448A JP 6998656 B2 JP6998656 B2 JP 6998656B2
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lincrna
nucleic acid
human animal
locus
lncrna
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JP2016526924A5 (enExample
JP2016526924A (ja
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カ－マン， ビーナス ライ，
グオチュン ゴン，
ジョン リン，
デイビッド フレンドウェイ，
デイビッド エム． ヴァレンズエラ，
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A01K2217/077—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out heterozygous knock out animals displaying phenotype
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Life Sciences & Earth Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • Developmental Biology & Embryology (AREA)
  • Analytical Chemistry (AREA)
  • Transplantation (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2016533448A 2013-08-07 2014-08-07 ｌｉｎｃＲＮＡ欠失非ヒト動物 Active JP6998656B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361863147P 2013-08-07 2013-08-07
US61/863,147 2013-08-07
PCT/US2014/050178 WO2015021298A2 (en) 2013-08-07 2014-08-07 Lincrna-deficient non-human animals

Related Child Applications (3)

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JP2017037511A Division JP6192865B2 (ja) 2013-08-07 2017-02-28 ｌｉｎｃＲＮＡ欠失非ヒト動物
JP2018235716A Division JP2019037253A (ja) 2013-08-07 2018-12-17 ｌｉｎｃＲＮＡ欠失非ヒト動物
JP2020070279A Division JP2020108409A (ja) 2013-08-07 2020-04-09 ｌｉｎｃＲＮＡ欠失非ヒト動物

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JP2016526924A JP2016526924A (ja) 2016-09-08
JP2016526924A5 JP2016526924A5 (enExample) 2017-09-14
JP6998656B2 true JP6998656B2 (ja) 2022-02-04

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JP2016533448A Active JP6998656B2 (ja) 2013-08-07 2014-08-07 ｌｉｎｃＲＮＡ欠失非ヒト動物
JP2017037511A Active JP6192865B2 (ja) 2013-08-07 2017-02-28 ｌｉｎｃＲＮＡ欠失非ヒト動物
JP2018235716A Withdrawn JP2019037253A (ja) 2013-08-07 2018-12-17 ｌｉｎｃＲＮＡ欠失非ヒト動物
JP2020070279A Pending JP2020108409A (ja) 2013-08-07 2020-04-09 ｌｉｎｃＲＮＡ欠失非ヒト動物
JP2022109170A Withdrawn JP2022125255A (ja) 2013-08-07 2022-07-06 ｌｉｎｃＲＮＡ欠失非ヒト動物
JP2024146626A Pending JP2024164230A (ja) 2013-08-07 2024-08-28 ｌｉｎｃＲＮＡ欠失非ヒト動物

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JP2017037511A Active JP6192865B2 (ja) 2013-08-07 2017-02-28 ｌｉｎｃＲＮＡ欠失非ヒト動物
JP2018235716A Withdrawn JP2019037253A (ja) 2013-08-07 2018-12-17 ｌｉｎｃＲＮＡ欠失非ヒト動物
JP2020070279A Pending JP2020108409A (ja) 2013-08-07 2020-04-09 ｌｉｎｃＲＮＡ欠失非ヒト動物
JP2022109170A Withdrawn JP2022125255A (ja) 2013-08-07 2022-07-06 ｌｉｎｃＲＮＡ欠失非ヒト動物
JP2024146626A Pending JP2024164230A (ja) 2013-08-07 2024-08-28 ｌｉｎｃＲＮＡ欠失非ヒト動物

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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11064685B2 (en) * 2017-02-27 2021-07-20 Regeneron Pharmaceuticals, Inc. Non-human animal models of retinoschisis
US20200246488A1 (en) * 2017-07-17 2020-08-06 The Broad Institute, Inc. Compositions and methods for treating inflammatory bowel diseases
IL313387A (en) 2017-09-19 2024-08-01 Tropic Biosciences Uk Ltd Modifying the specificity of non-coding rna molecules for silencing gene expression in eukaryotic cells
US11932858B2 (en) 2017-12-14 2024-03-19 Donald Danforth Plant Science Center Homologous recombination via transcriptional activation
CN108728545A (zh) * 2018-06-25 2018-11-02 汕头大学医学院附属肿瘤医院 结直肠癌长链非编码rna-hotair分子标志物及其应用
CN108950001B (zh) * 2018-08-31 2020-08-11 青岛泱深生物医药有限公司 一种与直肠腺癌发生发展相关的分子标志物
CN108866198B (zh) * 2018-08-31 2020-08-11 青岛泱深生物医药有限公司 标志物loc105376380在直肠腺癌诊断和治疗中的应用
CN108950000B (zh) * 2018-08-31 2020-08-04 青岛泱深生物医药有限公司 lncRNA在直肠腺癌诊疗中的应用
CN111218451B (zh) * 2020-02-05 2021-08-10 华中农业大学 一种提高猪肌肉量的方法
RU2752663C1 (ru) * 2020-05-18 2021-07-29 ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "СберМедИИ" Способ квантификации статистического анализа альтернативного сплайсинга в данных рнк-сек
WO2022138421A1 (ja) * 2020-12-22 2022-06-30 公立大学法人大阪 Ｘ染色体ノックインモデル動物
USD1010297S1 (en) * 2021-06-30 2024-01-09 Puma SE Shoe
CN113999873B (zh) * 2021-12-31 2022-05-20 北京市疾病预防控制中心 一种基因修饰的非人动物的构建方法及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013509192A (ja) 2009-10-29 2013-03-14 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 多機能性対立遺伝子

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
EP1802193B1 (en) 2004-10-19 2014-04-30 Regeneron Pharmaceuticals, Inc. Method for generating a mouse homozygous for a genetic modification
CN101619312B (zh) 2009-07-10 2011-04-20 四川大学 人黑色素瘤细胞特异表达的长非编码rna序列及其用途
CN101633923B (zh) * 2009-07-10 2011-04-13 四川大学 人黑色素瘤细胞相关的长非编码rna及其用途
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
US8518392B2 (en) 2009-08-14 2013-08-27 Regeneron Pharmaceuticals, Inc. Promoter-regulated differentiation-dependent self-deleting cassette
US20120004278A1 (en) 2010-06-18 2012-01-05 The Board Of Trustees Of The Leland Stanford Junior University Linc rnas in cancer diagnosis and treatment
WO2012018881A2 (en) 2010-08-03 2012-02-09 Alnylam Pharmaceuticals, Inc. Methods and compositions for the regulation of rna
WO2013134558A1 (en) 2012-03-07 2013-09-12 The Texas A & M University System Cancer treatment targeting non-coding rna overexpression
JP6475172B2 (ja) 2013-02-20 2019-02-27 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ラットの遺伝子組換え
EP3456831B1 (en) 2013-04-16 2021-07-14 Regeneron Pharmaceuticals, Inc. Targeted modification of rat genome
BR112017019620A2 (pt) * 2015-03-16 2018-05-15 Regeneron Pharmaceuticals, Inc. ?roedor geneticamente modificado, célula ou tecido, métodos para produção de um roedor geneticamente modificado e de uma população de neurônios motores, métodos para seleção de um agente candidato para modular a disfunção neuronal motora e de um agente candidato para redução do estresse oxidativo em um neurônio motor, ácido nucleico, e, célula de roedor?

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013509192A (ja) 2009-10-29 2013-03-14 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 多機能性対立遺伝子

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Ｃｅｌｌ，２０１０年，Ｖｏｌ．１４２，Ｎｏ．３，ｐｐ．４０９－４１９
Ｃｕｒｒｅｎｔ Ｂｉｏｌｏｇｙ，２００５年，Ｖｏｌ．１５，ｐｐ．５０１－５１２
Ｄｅｖｅｌｏｐｍｅｎｔａｌ Ｃｅｌｌ，２０１３年 １月，Ｖｏｌ．２４，Ｎｏ．２，ｐ．２０６－２１４及びＳｕｐｐｌｅｍｅｎｔａｌ Ｒｅｆｅｒｅｎｃｅｓ
Ｇｅｎｏｍｅ Ｒｅｓｅａｒｃｈ，２０１２年 １０月（Ｅｐｕｂ），Ｖｏｌ．２３，Ｎｏ．１，ｐｐ．２３－３３
Ｎａｔｕｒｅ，２００９年，Ｖｏｌ．４５８，ｐｐ．２２３－２２７
Ｎａｔｕｒｅ，２０１１年，Ｖｏｌ．４７２，ｐｐ．１２０－１２４及びＭＥＴＨＯＤＳ
Ｔｒａｎｓｇｅｎｉｃ Ｒｅｓｅａｒｃｈ，２０１３年 ２月，Ｖｏｌ．２３，ｐｐ．２０１－２５０

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WO2015021298A2 (en) 2015-02-12
ES2812242T3 (es) 2021-03-16
RU2721855C2 (ru) 2020-05-25
DK3178928T3 (da) 2020-08-24
AU2018200281B2 (en) 2020-10-08
CN112715485A (zh) 2021-04-30
EP3178928A1 (en) 2017-06-14
JP2022125255A (ja) 2022-08-26
EP3030653A4 (en) 2017-07-26
US20230189771A1 (en) 2023-06-22
CN105518132B (zh) 2021-02-05
RU2016107434A (ru) 2017-09-15
WO2015021298A3 (en) 2015-04-02
MY198884A (en) 2023-10-02
MX2016001682A (es) 2017-04-13
US11547100B2 (en) 2023-01-10
JP2020108409A (ja) 2020-07-16
MX369452B (es) 2019-11-08
IL243581B (en) 2022-08-01
CN105518132A (zh) 2016-04-20
AU2017200183C1 (en) 2023-04-27
CA2917714A1 (en) 2015-02-12
AU2014305873A1 (en) 2016-02-04
MY182065A (en) 2021-01-18
MX2019013309A (es) 2020-07-28
JP6192865B2 (ja) 2017-09-06
NZ716168A (en) 2022-05-27
US20170071173A1 (en) 2017-03-16
SG11201600036QA (en) 2016-02-26
IL243581A0 (en) 2016-03-31
ZA201600170B (en) 2022-03-30
JP2024164230A (ja) 2024-11-26
EP3178928B1 (en) 2020-06-10
BR112016002385A2 (pt) 2017-09-12
SG10201803766UA (en) 2018-06-28
AU2018200281A1 (en) 2018-02-01
MX2022013409A (es) 2022-11-14
US9554564B2 (en) 2017-01-31
KR102138723B1 (ko) 2020-07-29
US20150047062A1 (en) 2015-02-12
JP2016526924A (ja) 2016-09-08
HK1220990A1 (zh) 2017-05-19
JP2017099407A (ja) 2017-06-08
AU2014305873B2 (en) 2017-08-31
AU2017200183A1 (en) 2017-02-02
AU2017200183B2 (en) 2018-02-01
KR20160035585A (ko) 2016-03-31
KR20170012567A (ko) 2017-02-02
KR101853466B1 (ko) 2018-04-30
IL294443A (en) 2022-09-01
JP2019037253A (ja) 2019-03-14
KR102350200B1 (ko) 2022-01-14
KR20200090977A (ko) 2020-07-29

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