BR112016002385A2 - animal não humano, célula, tecido ou embrião, vetor de alvejamento, constructo de vetor de alvejamento, e, métodos para produzir um animal não humano e para modificar um lócus de incrna em uma célula pluripotente - Google Patents
animal não humano, célula, tecido ou embrião, vetor de alvejamento, constructo de vetor de alvejamento, e, métodos para produzir um animal não humano e para modificar um lócus de incrna em uma célula pluripotenteInfo
- Publication number
- BR112016002385A2 BR112016002385A2 BR112016002385A BR112016002385A BR112016002385A2 BR 112016002385 A2 BR112016002385 A2 BR 112016002385A2 BR 112016002385 A BR112016002385 A BR 112016002385A BR 112016002385 A BR112016002385 A BR 112016002385A BR 112016002385 A2 BR112016002385 A2 BR 112016002385A2
- Authority
- BR
- Brazil
- Prior art keywords
- targeting vector
- nonhuman animal
- cell
- methods
- embryo
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract 3
- 230000008685 targeting Effects 0.000 title 2
- 210000001161 mammalian embryo Anatomy 0.000 title 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 210000002257 embryonic structure Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
- A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A01K2217/077—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out heterozygous knock out animals displaying phenotype
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Reproductive Health (AREA)
- Developmental Biology & Embryology (AREA)
- Analytical Chemistry (AREA)
- Transplantation (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Gynecology & Obstetrics (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361863147P | 2013-08-07 | 2013-08-07 | |
| PCT/US2014/050178 WO2015021298A2 (en) | 2013-08-07 | 2014-08-07 | Lincrna-deficient non-human animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112016002385A2 true BR112016002385A2 (pt) | 2017-09-12 |
Family
ID=52449819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016002385A BR112016002385A2 (pt) | 2013-08-07 | 2014-08-07 | animal não humano, célula, tecido ou embrião, vetor de alvejamento, constructo de vetor de alvejamento, e, métodos para produzir um animal não humano e para modificar um lócus de incrna em uma célula pluripotente |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9554564B2 (enExample) |
| EP (2) | EP3030653A4 (enExample) |
| JP (6) | JP6998656B2 (enExample) |
| KR (3) | KR102138723B1 (enExample) |
| CN (2) | CN105518132B (enExample) |
| AU (3) | AU2014305873B2 (enExample) |
| BR (1) | BR112016002385A2 (enExample) |
| CA (1) | CA2917714A1 (enExample) |
| DK (1) | DK3178928T3 (enExample) |
| ES (1) | ES2812242T3 (enExample) |
| HK (1) | HK1220990A1 (enExample) |
| IL (2) | IL294443A (enExample) |
| MX (3) | MX369452B (enExample) |
| MY (2) | MY182065A (enExample) |
| NZ (1) | NZ716168A (enExample) |
| RU (1) | RU2721855C2 (enExample) |
| SG (2) | SG11201600036QA (enExample) |
| WO (1) | WO2015021298A2 (enExample) |
| ZA (1) | ZA201600170B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11064685B2 (en) * | 2017-02-27 | 2021-07-20 | Regeneron Pharmaceuticals, Inc. | Non-human animal models of retinoschisis |
| US20200246488A1 (en) * | 2017-07-17 | 2020-08-06 | The Broad Institute, Inc. | Compositions and methods for treating inflammatory bowel diseases |
| IL313387A (en) | 2017-09-19 | 2024-08-01 | Tropic Biosciences Uk Ltd | Modifying the specificity of non-coding rna molecules for silencing gene expression in eukaryotic cells |
| US11932858B2 (en) | 2017-12-14 | 2024-03-19 | Donald Danforth Plant Science Center | Homologous recombination via transcriptional activation |
| CN108728545A (zh) * | 2018-06-25 | 2018-11-02 | 汕头大学医学院附属肿瘤医院 | 结直肠癌长链非编码rna-hotair分子标志物及其应用 |
| CN108950001B (zh) * | 2018-08-31 | 2020-08-11 | 青岛泱深生物医药有限公司 | 一种与直肠腺癌发生发展相关的分子标志物 |
| CN108866198B (zh) * | 2018-08-31 | 2020-08-11 | 青岛泱深生物医药有限公司 | 标志物loc105376380在直肠腺癌诊断和治疗中的应用 |
| CN108950000B (zh) * | 2018-08-31 | 2020-08-04 | 青岛泱深生物医药有限公司 | lncRNA在直肠腺癌诊疗中的应用 |
| CN111218451B (zh) * | 2020-02-05 | 2021-08-10 | 华中农业大学 | 一种提高猪肌肉量的方法 |
| RU2752663C1 (ru) * | 2020-05-18 | 2021-07-29 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "СберМедИИ" | Способ квантификации статистического анализа альтернативного сплайсинга в данных рнк-сек |
| WO2022138421A1 (ja) * | 2020-12-22 | 2022-06-30 | 公立大学法人大阪 | Ｘ染色体ノックインモデル動物 |
| USD1010297S1 (en) * | 2021-06-30 | 2024-01-09 | Puma SE | Shoe |
| CN113999873B (zh) * | 2021-12-31 | 2022-05-20 | 北京市疾病预防控制中心 | 一种基因修饰的非人动物的构建方法及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| EP1802193B1 (en) | 2004-10-19 | 2014-04-30 | Regeneron Pharmaceuticals, Inc. | Method for generating a mouse homozygous for a genetic modification |
| CN101619312B (zh) | 2009-07-10 | 2011-04-20 | 四川大学 | 人黑色素瘤细胞特异表达的长非编码rna序列及其用途 |
| CN101633923B (zh) * | 2009-07-10 | 2011-04-13 | 四川大学 | 人黑色素瘤细胞相关的长非编码rna及其用途 |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| US8518392B2 (en) | 2009-08-14 | 2013-08-27 | Regeneron Pharmaceuticals, Inc. | Promoter-regulated differentiation-dependent self-deleting cassette |
| TR201903376T4 (tr) * | 2009-10-29 | 2019-04-22 | Regeneron Pharma | Çok fonksiyonlu alleller. |
| US20120004278A1 (en) | 2010-06-18 | 2012-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Linc rnas in cancer diagnosis and treatment |
| WO2012018881A2 (en) | 2010-08-03 | 2012-02-09 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for the regulation of rna |
| WO2013134558A1 (en) | 2012-03-07 | 2013-09-12 | The Texas A & M University System | Cancer treatment targeting non-coding rna overexpression |
| JP6475172B2 (ja) | 2013-02-20 | 2019-02-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ラットの遺伝子組換え |
| EP3456831B1 (en) | 2013-04-16 | 2021-07-14 | Regeneron Pharmaceuticals, Inc. | Targeted modification of rat genome |
| BR112017019620A2 (pt) * | 2015-03-16 | 2018-05-15 | Regeneron Pharmaceuticals, Inc. | ?roedor geneticamente modificado, célula ou tecido, métodos para produção de um roedor geneticamente modificado e de uma população de neurônios motores, métodos para seleção de um agente candidato para modular a disfunção neuronal motora e de um agente candidato para redução do estresse oxidativo em um neurônio motor, ácido nucleico, e, célula de roedor? |
-
2014
- 2014-08-07 IL IL294443A patent/IL294443A/en unknown
- 2014-08-07 MY MYPI2016700017A patent/MY182065A/en unknown
- 2014-08-07 BR BR112016002385A patent/BR112016002385A2/pt not_active Application Discontinuation
- 2014-08-07 CN CN201480042722.1A patent/CN105518132B/zh active Active
- 2014-08-07 IL IL243581A patent/IL243581B/en unknown
- 2014-08-07 SG SG11201600036QA patent/SG11201600036QA/en unknown
- 2014-08-07 DK DK17152034.9T patent/DK3178928T3/da active
- 2014-08-07 CN CN202110062319.7A patent/CN112715485A/zh active Pending
- 2014-08-07 CA CA2917714A patent/CA2917714A1/en active Pending
- 2014-08-07 EP EP14834544.0A patent/EP3030653A4/en not_active Withdrawn
- 2014-08-07 HK HK16109080.4A patent/HK1220990A1/zh unknown
- 2014-08-07 NZ NZ716168A patent/NZ716168A/en unknown
- 2014-08-07 KR KR1020167002367A patent/KR102138723B1/ko active Active
- 2014-08-07 EP EP17152034.9A patent/EP3178928B1/en active Active
- 2014-08-07 US US14/454,464 patent/US9554564B2/en active Active
- 2014-08-07 MX MX2016001682A patent/MX369452B/es active IP Right Grant
- 2014-08-07 MY MYPI2018702265A patent/MY198884A/en unknown
- 2014-08-07 ES ES17152034T patent/ES2812242T3/es active Active
- 2014-08-07 JP JP2016533448A patent/JP6998656B2/ja active Active
- 2014-08-07 RU RU2016107434A patent/RU2721855C2/ru active
- 2014-08-07 KR KR1020207021344A patent/KR102350200B1/ko not_active Expired - Fee Related
- 2014-08-07 AU AU2014305873A patent/AU2014305873B2/en active Active
- 2014-08-07 KR KR1020177001244A patent/KR101853466B1/ko active Active
- 2014-08-07 WO PCT/US2014/050178 patent/WO2015021298A2/en not_active Ceased
- 2014-08-07 SG SG10201803766UA patent/SG10201803766UA/en unknown
-
2016
- 2016-01-08 ZA ZA2016/00170A patent/ZA201600170B/en unknown
- 2016-02-05 MX MX2022013409A patent/MX2022013409A/es unknown
- 2016-02-05 MX MX2019013309A patent/MX2019013309A/es unknown
- 2016-11-30 US US15/365,250 patent/US11547100B2/en active Active
-
2017
- 2017-01-11 AU AU2017200183A patent/AU2017200183C1/en active Active
- 2017-02-28 JP JP2017037511A patent/JP6192865B2/ja active Active
-
2018
- 2018-01-12 AU AU2018200281A patent/AU2018200281B2/en active Active
- 2018-12-17 JP JP2018235716A patent/JP2019037253A/ja not_active Withdrawn
-
2020
- 2020-04-09 JP JP2020070279A patent/JP2020108409A/ja active Pending
-
2022
- 2022-07-06 JP JP2022109170A patent/JP2022125255A/ja not_active Withdrawn
- 2022-11-16 US US18/056,118 patent/US20230189771A1/en active Pending
-
2024
- 2024-08-28 JP JP2024146626A patent/JP2024164230A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112016002385A2 (pt) | animal não humano, célula, tecido ou embrião, vetor de alvejamento, constructo de vetor de alvejamento, e, métodos para produzir um animal não humano e para modificar um lócus de incrna em uma célula pluripotente | |
| AU2019264610A1 (en) | Genetically modified animals and methods for making the same | |
| BR112015029904A2 (pt) | animais geneticamente estéreis | |
| BR112016011004A2 (pt) | animal roedor geneticamente modificado, célula tronco embrionária de roedor, embrião de roedor, e, métodos para fabricar um animal roedor e para enxertar células humanas em um camundongo | |
| BR112016011003A2 (pt) | animal roedor geneticamente modificado, célula tronco embrionária de camundongo, embrião de camundongo, e, métodos para fabricar um animal roedor e para enxertar células humanas em um camundongo | |
| BR112016029650A2 (pt) | roedor, polipeptídeo pd-1, célula isolada ou tecido de roedor, célula-tronco embrionária de roedor, métodos de produzir um roedor, de reduzir o crescimento de tumor em um roedor, de matar células tumorais em um roedor e de avaliar as propriedades farmacocinéticas de uma droga que direciona pd-1 humano, e, modelo de tumor de roedor? | |
| BR112017010793A2 (pt) | animal não humano geneticamente modificado, camundongo, métodos para produzir um animal não humano geneticamente modificado e de triagem de candidatos a fármaco direcionados a um antígeno de interesse, e, modelo de camundongo. | |
| CY1119071T1 (el) | Εξανθρωποποιημενα il-7 τρωκτικα | |
| MX2019012311A (es) | Metodos y composiciones para modificaciones geneticas dirigidas y metodos de uso. | |
| MX355726B (es) | Ratones transgenicos que expresan moleculas quimericas del complejo mayor de histocompatibilidad (cmh) clase ii. | |
| PH12015500213A1 (en) | Production of fmdv-resistant livestock by allele substitution | |
| MX2022001201A (es) | Ratones con genes insertados de sirp¿-il15 humanizadas y métodos para usarlos. | |
| BR112016006261A2 (pt) | camundongo, célula ou tecido de camundongo isolado, e, métodos para produzir um camundongo, para enxertar células humanas em um camundongo e para avaliar a eficácia terapêutica de uma droga que alveja células humanas | |
| PL3313991T3 (pl) | Modyfikowany czynnik ix oraz kompozycje, sposoby i zastosowania do transferu genów do komórek, narządów i tkanek | |
| MX389266B (es) | Metodos y composiciones para la modificacion genetica dirigida mediante el uso de arn guia combinados. | |
| BR112014026186A2 (pt) | método de transfecção celular | |
| BR112017010490A2 (pt) | roedor, polipeptídeo cd47, célula ou tecido de roedor isolado, célula-tronco emprionária de roedor, embrião de roedor, e, métodos de produzir um roedor, de fornecimento de um roedor, de enxerto de células humanas em um roedor, de avaliação de eficácia terapêutica de uma droga direcionada a células humanas e de avaliar as propriedades farmacocinéticas, de avaliar a toxicidade específica e inespecífica de uma droga direcionada ao cd47 humano. | |
| BR112014018843A8 (pt) | métodos para obter um animal não humano, para produzir uma protéina e para modificar um locus de cadeia pesada de imunoglobulina de um roedor, e, hibridoma | |
| MX2021013914A (es) | Células, tejidos, órganos y/o animales que tienen uno o más genes modificados para supervivencia y/o tolerancia de xenoinjerto mejorada. | |
| CA2903025C (en) | Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules | |
| MX373055B (es) | Animales con dipeptidil peptidasa iv (dpp4) humanizada. | |
| BR112019001783A2 (pt) | mamífero não humano, e, métodos para produzir o mamífero não humano e de triagem de um composto. | |
| MX388475B (es) | Selección de células pluripotentes para producir ratones hembra xy fértiles. | |
| BR112017000925A2 (pt) | animal de criação, linhagem germinativa receptora ablactada, esperma, célula de animal de criação, método de reprodução de animais de criação, método para gerar um animal de criação sem nenhuma célula espermatogônica funcional, método de produção de um macho receptor, método de produção de animais de criação | |
| AR110687A1 (es) | Polipéptidos con actividad lisozima, polinucleótidos que codifican los mismos, usos y composiciones de los mismos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI. |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |