BR112021024003A2 - Métodos de tratamento de câncer com fusão sirp alfa-fc em combinação com um inibidor de checkpoint imunológico - Google Patents
Métodos de tratamento de câncer com fusão sirp alfa-fc em combinação com um inibidor de checkpoint imunológicoInfo
- Publication number
- BR112021024003A2 BR112021024003A2 BR112021024003A BR112021024003A BR112021024003A2 BR 112021024003 A2 BR112021024003 A2 BR 112021024003A2 BR 112021024003 A BR112021024003 A BR 112021024003A BR 112021024003 A BR112021024003 A BR 112021024003A BR 112021024003 A2 BR112021024003 A2 BR 112021024003A2
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- Prior art keywords
- treatment methods
- antibody
- cancer treatment
- cancer
- fusion
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Zoology (AREA)
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- Oncology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
métodos de tratamento de câncer com fusão sirp alfa-fc em combinação com um inibidor de checkpoint imunológico. são fornecidos métodos de tratamento do câncer (por exemplo, câncer de pulmão de células não pequenas (nsclc), carcinoma de células escamosas de cabeça e pescoço (hnscc), câncer gástrico/de junção gastroesofágica (gej) positivo para her2, linfoma difuso de células grandes b (dlbcl) de novo ou transformado ou linfoma indolente) em um indivíduo que compreende a administração ao indivíduo de (a) um polipeptídeo compreendendo uma variante do domínio sirpalfa d1 e uma variante do domínio fc e (b) um anticorpo anticâncer (por exemplo, um anticorpo anti-pd1, anticorpo anti-her2 ou um anticorpo anti-cd20). também são fornecidos kits de composições farmacêuticas relacionadas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962855821P | 2019-05-31 | 2019-05-31 | |
US202063022187P | 2020-05-08 | 2020-05-08 | |
PCT/US2020/034966 WO2020243338A1 (en) | 2019-05-31 | 2020-05-28 | Methods of treating cancer with sirp alpha fc fusion in combination with an immune checkpoint inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021024003A2 true BR112021024003A2 (pt) | 2022-04-19 |
Family
ID=71787033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021024003A BR112021024003A2 (pt) | 2019-05-31 | 2020-05-28 | Métodos de tratamento de câncer com fusão sirp alfa-fc em combinação com um inibidor de checkpoint imunológico |
Country Status (15)
Country | Link |
---|---|
US (3) | US11613564B2 (pt) |
EP (1) | EP3976099A1 (pt) |
JP (1) | JP2022534212A (pt) |
KR (1) | KR20220044904A (pt) |
CN (1) | CN114126648A (pt) |
AU (1) | AU2020282791A1 (pt) |
BR (1) | BR112021024003A2 (pt) |
CA (1) | CA3141130A1 (pt) |
CL (1) | CL2021003174A1 (pt) |
CO (1) | CO2021017299A2 (pt) |
IL (1) | IL288390A (pt) |
MA (1) | MA56045A (pt) |
MX (1) | MX2021014627A (pt) |
SG (1) | SG11202112733XA (pt) |
WO (1) | WO2020243338A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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SG10201912905VA (en) | 2015-08-07 | 2020-02-27 | Alx Oncology Inc | Constructs having a sirp-alpha domain or variant thereof |
AU2020282791A1 (en) | 2019-05-31 | 2021-12-09 | ALX Oncology Inc. | Methods of treating cancer with SIRP alpha Fc fusion in combination with an immune checkpoint inhibitor |
EP4335450A1 (en) | 2021-05-03 | 2024-03-13 | Cellemedy Co., Ltd | Pharmaceutical composition for prevention or treatment of lung cancer |
BR112023022774A2 (pt) * | 2021-05-13 | 2024-01-02 | Alx Oncology Inc | Terapias de combinação para tratamento de câncer |
TW202400650A (zh) * | 2022-05-11 | 2024-01-01 | 日商第一三共股份有限公司 | 抗體與cd47抑制劑之組合 |
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-
2020
- 2020-05-28 AU AU2020282791A patent/AU2020282791A1/en active Pending
- 2020-05-28 CA CA3141130A patent/CA3141130A1/en active Pending
- 2020-05-28 US US16/886,559 patent/US11613564B2/en active Active
- 2020-05-28 WO PCT/US2020/034966 patent/WO2020243338A1/en unknown
- 2020-05-28 BR BR112021024003A patent/BR112021024003A2/pt unknown
- 2020-05-28 MX MX2021014627A patent/MX2021014627A/es unknown
- 2020-05-28 MA MA056045A patent/MA56045A/fr unknown
- 2020-05-28 KR KR1020217043099A patent/KR20220044904A/ko unknown
- 2020-05-28 SG SG11202112733XA patent/SG11202112733XA/en unknown
- 2020-05-28 JP JP2021569055A patent/JP2022534212A/ja active Pending
- 2020-05-28 EP EP20746334.0A patent/EP3976099A1/en active Pending
- 2020-05-28 CN CN202080047746.1A patent/CN114126648A/zh active Pending
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2021
- 2021-11-25 IL IL288390A patent/IL288390A/en unknown
- 2021-11-29 CL CL2021003174A patent/CL2021003174A1/es unknown
- 2021-12-16 CO CONC2021/0017299A patent/CO2021017299A2/es unknown
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2022
- 2022-03-10 US US17/692,006 patent/US20220213166A1/en not_active Abandoned
- 2022-04-12 US US17/718,888 patent/US20220242928A1/en not_active Abandoned
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IL288390A (en) | 2022-01-01 |
MX2021014627A (es) | 2022-01-06 |
JP2022534212A (ja) | 2022-07-28 |
CA3141130A1 (en) | 2020-12-03 |
AU2020282791A1 (en) | 2021-12-09 |
US20200392199A1 (en) | 2020-12-17 |
EP3976099A1 (en) | 2022-04-06 |
KR20220044904A (ko) | 2022-04-12 |
CL2021003174A1 (es) | 2022-07-22 |
US20220242928A1 (en) | 2022-08-04 |
CN114126648A (zh) | 2022-03-01 |
US11613564B2 (en) | 2023-03-28 |
WO2020243338A1 (en) | 2020-12-03 |
SG11202112733XA (en) | 2021-12-30 |
CO2021017299A2 (es) | 2022-01-17 |
US20220213166A1 (en) | 2022-07-07 |
MA56045A (fr) | 2022-04-06 |
US20240132567A1 (en) | 2024-04-25 |
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