ES2973099T3 - Composiciones y procedimientos para el tratamiento de cánceres hematológicos dirigidos a la interacción entre SIRP alfa y CD47 - Google Patents
Composiciones y procedimientos para el tratamiento de cánceres hematológicos dirigidos a la interacción entre SIRP alfa y CD47Info
- Publication number
- ES2973099T3 ES2973099T3 ES15160169T ES15160169T ES2973099T3 ES 2973099 T3 ES2973099 T3 ES 2973099T3 ES 15160169 T ES15160169 T ES 15160169T ES 15160169 T ES15160169 T ES 15160169T ES 2973099 T3 ES2973099 T3 ES 2973099T3
- Authority
- ES
- Spain
- Prior art keywords
- procedures
- interaction
- compositions
- treatment
- hematological cancers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 title 1
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 101150036449 SIRPA gene Proteins 0.000 title 1
- 230000002489 hematologic effect Effects 0.000 title 1
- 230000003993 interaction Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17855309P | 2009-05-15 | 2009-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2973099T3 true ES2973099T3 (es) | 2024-06-18 |
Family
ID=43084582
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10774475.7T Active ES2539141T3 (es) | 2009-05-15 | 2010-05-14 | Composiciones y métodos para tratar cánceres hematológicos dirigiéndose a la interacción SIRPalfa - CD47 |
ES15160169T Active ES2973099T3 (es) | 2009-05-15 | 2010-05-14 | Composiciones y procedimientos para el tratamiento de cánceres hematológicos dirigidos a la interacción entre SIRP alfa y CD47 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10774475.7T Active ES2539141T3 (es) | 2009-05-15 | 2010-05-14 | Composiciones y métodos para tratar cánceres hematológicos dirigiéndose a la interacción SIRPalfa - CD47 |
Country Status (15)
Country | Link |
---|---|
US (3) | US10907209B2 (es) |
EP (3) | EP2995315B1 (es) |
JP (6) | JP6091891B2 (es) |
CN (2) | CN107252476A (es) |
AU (1) | AU2010246872B2 (es) |
CA (2) | CA2761438C (es) |
DK (2) | DK2995315T3 (es) |
ES (2) | ES2539141T3 (es) |
FI (1) | FI2995315T3 (es) |
HR (2) | HRP20240362T1 (es) |
HU (1) | HUE065432T2 (es) |
PL (2) | PL2995315T3 (es) |
PT (2) | PT2429574E (es) |
SI (2) | SI2995315T1 (es) |
WO (1) | WO2010130053A1 (es) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3170329A1 (en) | 2008-01-15 | 2009-07-23 | Siddhartha Jaiswal | Methods for manilpulating phagocytosis mediated by cd47 |
CA2761438C (en) | 2009-05-15 | 2017-12-12 | University Health Network | Compositions and methods for treating hematologic cancers targeting the sirp.alpha.-cd47 interaction |
EP3766511A1 (en) * | 2012-01-17 | 2021-01-20 | The Board of Trustees of the Leland Stanford Junior University | High affinity sirp-alpha reagents |
AU2013211871B2 (en) | 2012-01-25 | 2017-12-14 | Board Of Regents, The University Of Texas System | Biomarkers and combination therapies using oncolytic virus and immunomodulation |
CN102643347A (zh) * | 2012-03-29 | 2012-08-22 | 中国人民解放军第四军医大学 | 一种白血病干细胞靶向可溶性蛋白TrxHis-hSIRPα |
CN103804495A (zh) * | 2012-11-07 | 2014-05-21 | 深圳大学 | 抗肿瘤基因工程二价类抗体及其制备方法及抗肿瘤基因工程药物 |
ES2755156T3 (es) * | 2012-12-17 | 2020-04-21 | Trillium Therapeutics Inc | Tratamiento de células enfermas CD47+ con fusiones SIRP alfa-Fc |
WO2014121093A1 (en) * | 2013-01-31 | 2014-08-07 | Thomas Jefferson University | Fusion proteins that facilitate cancer cell destruction |
PT3721888T (pt) | 2013-02-05 | 2022-11-02 | Univ California | Terapias específicas cd47 para o tratamento de doenças infecciosas |
CN103665165B (zh) * | 2013-08-28 | 2016-02-24 | 江苏匡亚生物医药科技有限公司 | 一种靶向人CD47-SIRPα信号通路的双特异性抗体及其制备方法和用途 |
US9527901B2 (en) * | 2014-03-24 | 2016-12-27 | Macroimmune Inc | Recombinant bi-functional fusion proteins, preparations and methods for treating disease |
TWI759810B (zh) * | 2014-08-08 | 2022-04-01 | 美商Alx腫瘤技術股份有限公司 | 信號調節蛋白α(signal-regulatory proteinα, SIRP-α)變體構築物及其用途 |
KR20170036796A (ko) * | 2014-08-15 | 2017-04-03 | 메르크 파텐트 게엠베하 | Sirp-알파 면역글로불린 융합 단백질 |
EP3012271A1 (en) | 2014-10-24 | 2016-04-27 | Effimune | Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases |
CN106146670B (zh) * | 2015-04-24 | 2019-01-15 | 宜明昂科生物医药技术(上海)有限公司 | 一种新的重组双功能融合蛋白及其制备和应用 |
CN108350048B (zh) | 2015-08-07 | 2024-02-09 | Alx肿瘤生物技术公司 | 具有SIRP-α结构域或其变体的构建体 |
WO2017053423A1 (en) | 2015-09-21 | 2017-03-30 | Erasmus University Medical Center | Anti-cd47 antibodies and methods of use |
EP4186927A1 (en) | 2015-10-21 | 2023-05-31 | Ose Immunotherapeutics | Methods and compositions for modifying macrophage polarization into pro-inflammatory cells to treat cancer |
CN107149682B (zh) * | 2016-03-04 | 2022-01-04 | 复旦大学 | 一种靶向cd47的免疫检查点抑制剂药物组合物及其制备方法 |
IL262251B2 (en) | 2016-04-14 | 2023-09-01 | Ose Immunotherapeutics | New anti-syrap antibodies and their medical applications |
AU2017250029C1 (en) * | 2016-04-15 | 2022-03-24 | Pfizer Inc. | Macrophage stimulation in CD47 blockade therapy |
EP3458094A4 (en) * | 2016-05-19 | 2020-01-08 | Adaerata, Limited Partnership | METHOD FOR PREVENTING OR TREATING SLAMF7-POSITIVE AND SLAMF7-NEGATIVE CANCER |
EP3487522A4 (en) | 2016-07-19 | 2020-04-01 | Teva Pharmaceuticals Australia Pty Ltd | ANTI-CD47 COMBINATION THERAPY |
CA3042583A1 (en) | 2016-11-03 | 2018-05-11 | Trillium Therapeutics Inc. | Improvements in cd47 blockade therapy by hdac inhibitors |
WO2018081897A1 (en) | 2016-11-03 | 2018-05-11 | Trillium Therapeutics Inc. | Enhancement of cd47 blockade therapy by proteasome inhibitors |
CN118027200A (zh) | 2016-12-09 | 2024-05-14 | 艾利妥 | 抗SIRPα抗体及其使用方法 |
US11299530B2 (en) | 2017-01-05 | 2022-04-12 | Kahr Medical Ltd. | SIRP alpha-CD70 fusion protein and methods of use thereof |
CA3047708A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A sirpalpha-41bbl fusion protein and methods of use thereof |
DK3565579T3 (da) | 2017-01-05 | 2023-09-04 | Kahr Medical Ltd | Pd1-41bbl-fusionsprotein og fremgangsmåder til anvendelse deraf |
WO2018127916A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A pd1-cd70 fusion protein and methods of use thereof |
AU2018308364C1 (en) | 2017-07-26 | 2023-02-16 | Forty Seven, Inc. | Anti-SIRP-alpha antibodies and related methods |
BR112020001679A2 (pt) | 2017-08-02 | 2020-07-21 | Phanes Therapeutics, Inc. | anticorpos anti-cd47 e usos dos mesmos |
EP3694881A1 (en) | 2017-10-13 | 2020-08-19 | OSE Immunotherapeutics | Modified anti-sirpa antibodies and uses thereof |
WO2019084692A1 (en) | 2017-11-06 | 2019-05-09 | Trillium Therapeutics Inc. | Cd47 blockade with radiation therapy |
CN108484774B (zh) * | 2018-03-09 | 2021-11-05 | 上海高菲生物科技有限公司 | 一种SIRPα融合蛋白及其制备方法和用途 |
KR20210006338A (ko) * | 2018-03-13 | 2021-01-18 | 오제 이뮈노테라프틱스 | 항-인간 SIRPa v1 항체의 이용 및 항-SIRPa v1 항체를 생산하는 방법 |
CN110386984B (zh) * | 2018-04-17 | 2022-04-22 | 杭州尚健生物技术有限公司 | 结合cd47蛋白的融合蛋白及其应用 |
WO2019226973A1 (en) | 2018-05-25 | 2019-11-28 | Alector Llc | Anti-sirpa antibodies and methods of use thereof |
CN108872569A (zh) * | 2018-06-19 | 2018-11-23 | 浠思(上海)生物技术有限公司 | 利用HTRF一步法筛选CD47/SIRP alpha阻断剂的方法 |
EP3843772A2 (en) * | 2018-08-31 | 2021-07-07 | ALX Oncology Inc. | Decoy polypeptides |
MX2021014627A (es) | 2019-05-31 | 2022-01-06 | Alx Oncology Inc | Polipeptidos de citocinas enmascaradas. |
EP4197559A4 (en) * | 2020-08-14 | 2024-04-24 | Korea Institute of Science and Technology | ARNSI/IMMUNOMODULATING PROTEIN COMPLEX WITH ANTI-CANCER ACTIVITY |
KR102398032B1 (ko) * | 2020-09-22 | 2022-05-19 | 비피진 주식회사 | 암 치료를 위한 5''-뉴클레오티다아제 변이체 |
KR102557016B1 (ko) * | 2020-09-22 | 2023-07-20 | 비피진 주식회사 | 암 치료를 위한 cd47 바인더 및 리포좀 복합체 |
WO2022130016A1 (en) | 2020-12-18 | 2022-06-23 | Instil Bio (Uk) Limited | Tumor infiltrating lymphocytes and anti-cd47 therapeutics |
WO2022229818A1 (en) | 2021-04-27 | 2022-11-03 | Pf Argentum Ip Holdings Llc | Enhancement of cd47 blockade therapy with dhfr inhibitors |
IL308741A (en) | 2021-06-04 | 2024-01-01 | Boehringer Ingelheim Int | Anti-SIRP-alpha antibodies |
EP4362968A1 (en) * | 2021-06-30 | 2024-05-08 | Ohio State Innovation Foundation | Methods and compositions for inhibition of dihydroorotate dehydrogenase in combination with an anti-cd47-sirpa therapeutic agent |
CN118103060A (zh) * | 2021-08-05 | 2024-05-28 | 免疫标记治疗股份公司 | 包括hla融合蛋白的组合药物 |
WO2023073580A1 (en) | 2021-10-29 | 2023-05-04 | Pfizer Inc. | Enhancement of cd47 blockade with taxanes for cd47+ cancer therapy |
WO2023079438A1 (en) | 2021-11-08 | 2023-05-11 | Pfizer Inc. | Enhancement of cd47 blockade therapy with anti-vegf agents |
WO2023228044A1 (en) | 2022-05-25 | 2023-11-30 | Pfizer Inc. | Dosing regimens of sirp alpha fusion proteins for treatment of cancer |
WO2024040151A1 (en) | 2022-08-18 | 2024-02-22 | Pfizer Inc. | Sirp alpha fusion protein and anti-cd38 antibody combination therapies |
WO2024124107A2 (en) | 2022-12-09 | 2024-06-13 | Pfizer Inc. | Cd47 blocking agent and anti-cd20 / anti-cd3 bispecific antibody combination therapy |
WO2024121777A1 (en) | 2022-12-09 | 2024-06-13 | Pfizer Inc. | Cd47 blocking agent and anti-bcma / anti-cd3 bispecific antibody combination therapy |
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EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
US5580756A (en) | 1990-03-26 | 1996-12-03 | Bristol-Myers Squibb Co. | B7Ig fusion protein |
US5844095A (en) | 1991-06-27 | 1998-12-01 | Bristol-Myers Squibb Company | CTLA4 Ig fusion proteins |
WO1994029351A2 (en) | 1993-06-16 | 1994-12-22 | Celltech Limited | Antibodies |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
WO1997048723A2 (en) | 1996-06-17 | 1997-12-24 | MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. Hofgartenstrasse 2 | Ptp-20, pcp-2, bdp1, clk and sirp proteins and related products |
US6541615B1 (en) | 1996-11-15 | 2003-04-01 | Max-Planck-Gellschaft Zur Foderung Der Wissenschaften E.V. | SIRP proteins and uses thereof |
CA2226962A1 (en) * | 1998-02-16 | 1999-08-16 | Marie Sarfati | Use of binding agents to cd47 and its ligands in the treatment or the prophylaxis of various inflammatory, autoimmune and allergic diseases and in the treatment of graft rejection |
US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
EP1244707A1 (de) | 1999-11-30 | 2002-10-02 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Antikörper gegen signal-regulator-proteine |
GB9930706D0 (en) | 1999-12-24 | 2000-02-16 | Medical Res Council | Composition for inhibiting macrophage activity |
WO2002092784A2 (en) | 2001-05-15 | 2002-11-21 | Emory University | POLYNUCLEOTIDES AND POLYPEPTIDES RELATING TO THE MODULATION OF SIRP α-CD47 |
EP1369128A1 (en) * | 2002-06-07 | 2003-12-10 | Procorde GmbH | Inhibitors of glycoprotein VI and their therapeutic use |
US20040213792A1 (en) | 2003-04-24 | 2004-10-28 | Clemmons David R. | Method for inhibiting cellular activation by insulin-like growth factor-1 |
JP3936673B2 (ja) | 2003-06-02 | 2007-06-27 | 国立大学法人群馬大学 | Cd47部分ペプチドと抗shps−1モノクロナール抗体 |
JP4637749B2 (ja) * | 2003-11-11 | 2011-02-23 | 中外製薬株式会社 | ヒト化抗cd47抗体 |
JP2007008895A (ja) * | 2005-07-04 | 2007-01-18 | Chugai Pharmaceut Co Ltd | 抗cd47抗体とインテグリンリガンドとの併用 |
EP1910542B1 (en) | 2005-07-22 | 2009-12-02 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with fgfr fusion proteins |
US7514229B2 (en) | 2005-09-29 | 2009-04-07 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for diagnosing and evaluating treatment of blood disorders |
AU2007213709A1 (en) * | 2006-02-08 | 2007-08-16 | Targeted Molecular Diagnostics, Llc | Bivalent ErbB ligand binding molecules and methods for their preparation and use |
US8377448B2 (en) * | 2006-05-15 | 2013-02-19 | The Board Of Trustees Of The Leland Standford Junior University | CD47 related compositions and methods for treating immunological diseases and disorders |
US20100239578A1 (en) * | 2007-10-11 | 2010-09-23 | University Health Network | Modulation of sirp-alpha - cd47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor |
DE102007056623B3 (de) | 2007-11-23 | 2009-05-20 | Mtu Friedrichshafen Gmbh | Verfahren zur Regelung eines stationären Gasmotors |
JP2011518313A (ja) | 2008-01-15 | 2011-06-23 | ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | 急性骨髄性白血病幹細胞のマーカー |
CA3170329A1 (en) | 2008-01-15 | 2009-07-23 | Siddhartha Jaiswal | Methods for manilpulating phagocytosis mediated by cd47 |
EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
US20110237498A1 (en) | 2008-12-19 | 2011-09-29 | Novartis Ag | Soluble polypeptides for use in treating autoimmune and inflammatory disorders |
CA2761438C (en) * | 2009-05-15 | 2017-12-12 | University Health Network | Compositions and methods for treating hematologic cancers targeting the sirp.alpha.-cd47 interaction |
LT3789038T (lt) | 2010-05-14 | 2022-12-12 | The Board Of Trustees Of The Leland Stanford Junior University | Humanizuoti ir chimeriniai monokloniniai antikūnai prieš cd47 |
BR112014019331A2 (pt) | 2012-02-06 | 2022-07-12 | Inhibrx Inc | anticorpos para cd47 e métodos de uso desses |
ES2755156T3 (es) | 2012-12-17 | 2020-04-21 | Trillium Therapeutics Inc | Tratamiento de células enfermas CD47+ con fusiones SIRP alfa-Fc |
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2010
- 2010-05-14 CA CA2761438A patent/CA2761438C/en active Active
- 2010-05-14 AU AU2010246872A patent/AU2010246872B2/en active Active
- 2010-05-14 EP EP15160169.7A patent/EP2995315B1/en active Active
- 2010-05-14 DK DK15160169.7T patent/DK2995315T3/da active
- 2010-05-14 PT PT107744757T patent/PT2429574E/pt unknown
- 2010-05-14 EP EP23214532.6A patent/EP4311863A3/en active Pending
- 2010-05-14 CN CN201710476053.4A patent/CN107252476A/zh active Pending
- 2010-05-14 WO PCT/CA2010/000743 patent/WO2010130053A1/en active Application Filing
- 2010-05-14 JP JP2012510083A patent/JP6091891B2/ja active Active
- 2010-05-14 PL PL15160169.7T patent/PL2995315T3/pl unknown
- 2010-05-14 SI SI201032142T patent/SI2995315T1/sl unknown
- 2010-05-14 PL PL10774475T patent/PL2429574T3/pl unknown
- 2010-05-14 HU HUE15160169A patent/HUE065432T2/hu unknown
- 2010-05-14 PT PT151601697T patent/PT2995315T/pt unknown
- 2010-05-14 HR HRP20240362TT patent/HRP20240362T1/hr unknown
- 2010-05-14 DK DK10774475.7T patent/DK2429574T3/da active
- 2010-05-14 EP EP10774475.7A patent/EP2429574B1/en active Active
- 2010-05-14 SI SI201030950T patent/SI2429574T1/sl unknown
- 2010-05-14 CA CA2983972A patent/CA2983972C/en active Active
- 2010-05-14 FI FIEP15160169.7T patent/FI2995315T3/fi active
- 2010-05-14 CN CN2010800213987A patent/CN102596233A/zh active Pending
- 2010-05-14 ES ES10774475.7T patent/ES2539141T3/es active Active
- 2010-05-14 US US13/320,629 patent/US10907209B2/en active Active
- 2010-05-14 ES ES15160169T patent/ES2973099T3/es active Active
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2015
- 2015-05-25 HR HRP20150553TT patent/HRP20150553T1/hr unknown
- 2015-08-17 JP JP2015160462A patent/JP6254124B2/ja active Active
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2017
- 2017-11-14 JP JP2017218996A patent/JP6410911B2/ja active Active
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2018
- 2018-08-30 US US16/118,038 patent/US20190093174A1/en not_active Abandoned
- 2018-09-25 JP JP2018178322A patent/JP2019011347A/ja active Pending
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2020
- 2020-06-01 JP JP2020095230A patent/JP2020143146A/ja active Pending
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2022
- 2022-09-20 JP JP2022148798A patent/JP2022180495A/ja active Pending
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2023
- 2023-11-22 US US18/518,353 patent/US20240084399A1/en active Pending
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