ATE372784T1 - Rekombinante proteine, die epitope des humanen papillomavirus inseriert in einem adenylatecyclase protein oder in dessen fragmenten tragen, und deren terapeutischen verwendung. - Google Patents
Rekombinante proteine, die epitope des humanen papillomavirus inseriert in einem adenylatecyclase protein oder in dessen fragmenten tragen, und deren terapeutischen verwendung.Info
- Publication number
- ATE372784T1 ATE372784T1 AT04290741T AT04290741T ATE372784T1 AT E372784 T1 ATE372784 T1 AT E372784T1 AT 04290741 T AT04290741 T AT 04290741T AT 04290741 T AT04290741 T AT 04290741T AT E372784 T1 ATE372784 T1 AT E372784T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- adenylatecyclase
- terapeutic
- fragments
- recombinant proteins
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04290741A EP1576967B1 (de) | 2004-03-18 | 2004-03-18 | Rekombinante Proteine, die Epitope des humanen Papillomavirus inseriert in einem Adenylatecyclase Protein oder in dessen Fragmenten tragen, und deren terapeutischen Verwendung. |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE372784T1 true ATE372784T1 (de) | 2007-09-15 |
Family
ID=34833798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04290741T ATE372784T1 (de) | 2004-03-18 | 2004-03-18 | Rekombinante proteine, die epitope des humanen papillomavirus inseriert in einem adenylatecyclase protein oder in dessen fragmenten tragen, und deren terapeutischen verwendung. |
Country Status (19)
Country | Link |
---|---|
US (3) | US8628779B2 (de) |
EP (3) | EP1576967B1 (de) |
JP (2) | JP5438897B2 (de) |
KR (2) | KR101382250B1 (de) |
CN (1) | CN1956730B (de) |
AT (1) | ATE372784T1 (de) |
AU (1) | AU2005224036B2 (de) |
BR (1) | BRPI0508722A (de) |
CA (1) | CA2559235C (de) |
CY (1) | CY1107042T1 (de) |
DE (1) | DE602004008874T2 (de) |
DK (1) | DK1576967T3 (de) |
ES (1) | ES2293178T3 (de) |
MX (1) | MXPA06010469A (de) |
PL (1) | PL1576967T3 (de) |
PT (1) | PT1576967E (de) |
RU (1) | RU2441022C2 (de) |
SI (1) | SI1576967T1 (de) |
WO (1) | WO2005089792A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1188446B1 (de) | 2000-09-15 | 2009-08-05 | Institut Pasteur | Proteinhaltigen Vektoren zur Einführung von Moleküle in CD11b exprimirende Zellen |
PT1576967E (pt) | 2004-03-18 | 2007-12-03 | Pasteur Institut | Proteína recombinante que transporta epitopos do virús do papilloma humano inseridos numa proteína adenilato ciclase, ou no seu fragmento, e seus usos terapêuticos |
EP3412290B1 (de) * | 2006-03-27 | 2021-03-03 | The Regents of The University of California | Androgenrezeptor-modulator zur behandlung von prostatakrebs und androgenrezeptor-assoziierte erkrankungen |
US9486524B2 (en) | 2006-09-01 | 2016-11-08 | Genticel | Composition for eliciting a specific CTL response, comprising a lympho-ablative compound and a molecule that contains antigenic sequences and targets professional antigen presenting cells |
EP1894941A1 (de) * | 2006-09-01 | 2008-03-05 | Institut Pasteur | Behandlung von Gebärmutterhalskarzinomen mit einer rekombinanten Adenylat-Cyclase die HPV-Antigene trägt |
EP3584251A3 (de) * | 2007-05-31 | 2020-01-29 | Academisch Ziekenhuis Leiden h.o.d.n. LUMC | Hpv-epitope als ziel für zervikale tumoren infiltrierende t-zellen zur verwendung bei impfstoffen |
ES2331271B1 (es) * | 2007-06-29 | 2010-10-14 | Universidad Del Pais Vasco | Metodo para la internalizacion de bacterias no invasivas en celulas eucariotas. |
WO2009013018A2 (en) * | 2007-07-24 | 2009-01-29 | Stichting Katholieke Universiteit Radboud University Nijmegen Medical Centre | Compositions and methods for generating an immune response in a subject |
EP2411513B1 (de) * | 2009-03-23 | 2016-11-09 | Institut Pasteur | Mutierte cyaa-polypeptide und -polypeptidderivate mit eignung zur zuführung immunogener moleküle in eine zelle |
US20120237535A1 (en) * | 2009-09-11 | 2012-09-20 | Proyecto De Biomedicina Cima, S.L. | Therapeutic Compositions For The Treatment of HPV-Induced Diseases |
BR112013000912A2 (pt) * | 2010-07-15 | 2016-05-17 | British Columbia Cancer Agency | composições de antígeno e7 de papilomavírus humano e usos dos mesmos |
EP2478915A1 (de) * | 2011-01-24 | 2012-07-25 | Genticel | cyaA-getragene Polypeptid(e) und Verwendung zur Induzierung von therapeutischen und prophylaktischen Immunantworten |
WO2012172042A1 (en) | 2011-06-17 | 2012-12-20 | Universiteit Gent | Vaccines for chlamydia |
WO2013092875A1 (en) * | 2011-12-21 | 2013-06-27 | Vaccibody As | Vaccines against hpv |
EP2687849A1 (de) * | 2012-07-20 | 2014-01-22 | ISA Pharmaceuticals B.V | Verfahren zur Bereitstellung einer optimierten Immuntherapiezusammensetzung |
EP2689786A1 (de) | 2012-07-23 | 2014-01-29 | Genticel | HPV/CYAA-basierte chimäre Proteine und deren Verwendungen bei der Induktion von Immunreaktionen gegen eine HPV-Infektion und HPV-induzierter Störungen |
EP2690172A1 (de) * | 2012-07-23 | 2014-01-29 | Genticel | CYAA-basierte chimäre Proteine mit einem heterologen Polypeptid und deren Verwendungen bei der Induktion von Immunreaktionen |
WO2015018943A2 (en) * | 2013-08-08 | 2015-02-12 | Institut Pasteur | Correlation of disease activity with clonal expansions of human papillomavirus 16-specific cd8+ t-cells in patients with severe erosive oral lichen planus |
EP2975120A1 (de) * | 2014-07-17 | 2016-01-20 | Institut Pasteur | Monomeres und funktionelles Adenylatcyclase-CyaA-Toxin |
WO2016077382A2 (en) | 2014-11-11 | 2016-05-19 | Massachusetts Eye & Ear Infirmary | Conjunctivitis vaccines |
EP3037103A1 (de) | 2014-12-23 | 2016-06-29 | Genticel | Immunotherapeutischer Impfstoff mit E7-Proteinen von HPV16 und HPV18 fusioniert mit CyaA zur Verwendung bei mit HIV infizierten Personen |
KR20170126500A (ko) | 2015-03-16 | 2017-11-17 | 막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트 | Mhc 세포 라이브러리를 이용하여 신규한 면역원성 t 세포 에피토프를 검출하고 신규한 항원-특이적 t 세포 수용체를 단리하는 방법 |
WO2017211886A1 (en) * | 2016-06-07 | 2017-12-14 | Deutsches Krebsforschungszentrum | Improvement of hpv l2 peptide immunogenicity |
EP3323426A1 (de) | 2016-11-17 | 2018-05-23 | Ecole Nationale Vétérinaire de Toulouse | Immunogen- und impfstoffzusammensetzungen zur verwendung gegen bordetella-bronchiseptica-infektion |
WO2018091613A1 (en) | 2016-11-17 | 2018-05-24 | Ecole Nationale Vétérinaire de Toulouse | Immunogenic and vaccine compositions for use against bordetella bronchiseptica infection |
EP3342421A1 (de) | 2016-12-27 | 2018-07-04 | Genticel | Immunogene zusammensetzung mit cyaa-abgeleitetem polypeptid, das eine th1/th17-orientierte immunreaktion fördert |
AU2019276162A1 (en) * | 2018-05-30 | 2021-01-07 | Deutsches Krebsforschungszentrum | Combined prophylactic and therapeutic vaccines |
WO2021063917A1 (en) | 2019-10-01 | 2021-04-08 | Universiteit Gent | Vaccine against chlamydia in swine |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4015044A1 (de) * | 1990-05-10 | 1991-11-14 | Behringwerke Ag | Seroreaktive epitope auf proteinen des menschlichen papillomavirus (hpv) 18 |
SE9001705D0 (sv) * | 1990-05-11 | 1990-05-11 | Medscand Ab | Saett foer diagnostik av virusbaerande tumoerer genom immunoassay |
US6183745B1 (en) * | 1990-12-12 | 2001-02-06 | The University Of Queensland | Subunit papilloma virus vaccine and peptides for use therein |
CA2133999A1 (en) * | 1992-04-21 | 1993-10-28 | Daniel Ladant | Recombinant mutants for inducing specific immune responses |
EP1188446B1 (de) * | 2000-09-15 | 2009-08-05 | Institut Pasteur | Proteinhaltigen Vektoren zur Einführung von Moleküle in CD11b exprimirende Zellen |
CA2453880A1 (en) * | 2001-07-25 | 2003-02-06 | New York University | Use of glycosylceramides as adjuvants for vaccines against infections and cancer |
EP1489092A1 (de) | 2003-06-18 | 2004-12-22 | Institut Pasteur | Modifizierte Bordetella Adenylatcyclase mit oder ohne CD11b/CD18 Interaktionsdomäne und seine Verwendungen |
CA2546452C (en) * | 2003-11-21 | 2015-01-20 | Institut Pasteur | Recombinant adenylate cyclase toxin of bordetella induces t cell responses against tumoral antigens |
PT1576967E (pt) | 2004-03-18 | 2007-12-03 | Pasteur Institut | Proteína recombinante que transporta epitopos do virús do papilloma humano inseridos numa proteína adenilato ciclase, ou no seu fragmento, e seus usos terapêuticos |
EP1894941A1 (de) * | 2006-09-01 | 2008-03-05 | Institut Pasteur | Behandlung von Gebärmutterhalskarzinomen mit einer rekombinanten Adenylat-Cyclase die HPV-Antigene trägt |
PT2233569E (pt) | 2009-03-23 | 2014-10-06 | Pasteur Institut | Polipéptidos mutantes de cyaa e derivados de polipéptidos adequados para a entrega de moléculas imunogénicas numa célula |
-
2004
- 2004-03-18 PT PT04290741T patent/PT1576967E/pt unknown
- 2004-03-18 EP EP04290741A patent/EP1576967B1/de not_active Expired - Lifetime
- 2004-03-18 DK DK04290741T patent/DK1576967T3/da active
- 2004-03-18 PL PL04290741T patent/PL1576967T3/pl unknown
- 2004-03-18 SI SI200430519T patent/SI1576967T1/sl unknown
- 2004-03-18 AT AT04290741T patent/ATE372784T1/de active
- 2004-03-18 ES ES04290741T patent/ES2293178T3/es not_active Expired - Lifetime
- 2004-03-18 DE DE602004008874T patent/DE602004008874T2/de not_active Expired - Lifetime
-
2005
- 2005-03-18 KR KR1020067021582A patent/KR101382250B1/ko active IP Right Grant
- 2005-03-18 BR BRPI0508722-8A patent/BRPI0508722A/pt not_active Application Discontinuation
- 2005-03-18 CN CN2005800087095A patent/CN1956730B/zh active Active
- 2005-03-18 JP JP2007503308A patent/JP5438897B2/ja active Active
- 2005-03-18 RU RU2006131598/10A patent/RU2441022C2/ru active
- 2005-03-18 EP EP10181329.3A patent/EP2351580B1/de active Active
- 2005-03-18 KR KR1020137016447A patent/KR101495740B1/ko active IP Right Grant
- 2005-03-18 MX MXPA06010469A patent/MXPA06010469A/es active IP Right Grant
- 2005-03-18 WO PCT/EP2005/003452 patent/WO2005089792A1/en active Application Filing
- 2005-03-18 AU AU2005224036A patent/AU2005224036B2/en active Active
- 2005-03-18 EP EP05728249.3A patent/EP1725259B1/de active Active
- 2005-03-18 CA CA2559235A patent/CA2559235C/en active Active
-
2006
- 2006-09-08 US US11/517,313 patent/US8628779B2/en active Active
-
2007
- 2007-11-29 CY CY20071101529T patent/CY1107042T1/el unknown
-
2010
- 2010-12-23 US US12/977,754 patent/US8637039B2/en active Active
-
2013
- 2013-05-21 JP JP2013107236A patent/JP5824474B2/ja active Active
- 2013-12-16 US US14/106,921 patent/US9387243B2/en active Active
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