SG10201912905VA - Constructs having a sirp-alpha domain or variant thereof - Google Patents
Constructs having a sirp-alpha domain or variant thereofInfo
- Publication number
- SG10201912905VA SG10201912905VA SG10201912905VA SG10201912905VA SG10201912905VA SG 10201912905V A SG10201912905V A SG 10201912905VA SG 10201912905V A SG10201912905V A SG 10201912905VA SG 10201912905V A SG10201912905V A SG 10201912905VA SG 10201912905V A SG10201912905V A SG 10201912905VA
- Authority
- SG
- Singapore
- Prior art keywords
- sirp
- constructs
- variant
- alpha domain
- alpha
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Wood Science & Technology (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562202772P | 2015-08-07 | 2015-08-07 | |
US201562202775P | 2015-08-07 | 2015-08-07 | |
US201562202779P | 2015-08-07 | 2015-08-07 | |
US201562265887P | 2015-12-10 | 2015-12-10 | |
US201662276801P | 2016-01-08 | 2016-01-08 | |
US201662276796P | 2016-01-08 | 2016-01-08 | |
US201662346414P | 2016-06-06 | 2016-06-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201912905VA true SG10201912905VA (en) | 2020-02-27 |
Family
ID=57983500
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202101909RA SG10202101909RA (en) | 2015-08-07 | 2016-08-05 | Constructs having a sirp-alpha domain or variant thereof |
SG10201912905VA SG10201912905VA (en) | 2015-08-07 | 2016-08-05 | Constructs having a sirp-alpha domain or variant thereof |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202101909RA SG10202101909RA (en) | 2015-08-07 | 2016-08-05 | Constructs having a sirp-alpha domain or variant thereof |
Country Status (34)
Country | Link |
---|---|
US (4) | US10259859B2 (en) |
EP (2) | EP3331902B1 (en) |
JP (3) | JP6898303B2 (en) |
KR (1) | KR20180028548A (en) |
CN (3) | CN117964732A (en) |
AU (2) | AU2016304794B2 (en) |
BR (1) | BR112018001353A2 (en) |
CA (1) | CA2993835A1 (en) |
CL (3) | CL2018000340A1 (en) |
CO (1) | CO2018002471A2 (en) |
CY (1) | CY1124372T1 (en) |
DK (1) | DK3331902T3 (en) |
ES (1) | ES2881771T3 (en) |
GE (2) | GEP20217326B (en) |
HK (1) | HK1257372A1 (en) |
HR (1) | HRP20211167T1 (en) |
HU (1) | HUE055139T2 (en) |
IL (3) | IL302491A (en) |
LT (1) | LT3331902T (en) |
MX (2) | MX2018001428A (en) |
MY (1) | MY185014A (en) |
NZ (1) | NZ738950A (en) |
PE (1) | PE20180778A1 (en) |
PH (1) | PH12018500269A1 (en) |
PL (1) | PL3331902T3 (en) |
PT (1) | PT3331902T (en) |
RS (1) | RS62151B1 (en) |
RU (2) | RU2740672C2 (en) |
SA (1) | SA518390881B1 (en) |
SG (2) | SG10202101909RA (en) |
SI (1) | SI3331902T1 (en) |
UA (1) | UA125638C2 (en) |
WO (1) | WO2017027422A1 (en) |
ZA (3) | ZA201800857B (en) |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10053513B2 (en) * | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
CN117964732A (en) | 2015-08-07 | 2024-05-03 | Alx肿瘤生物技术公司 | Constructs with SIRP-alpha domains or variants thereof |
WO2017035480A1 (en) | 2015-08-26 | 2017-03-02 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced depletion of targeted cells with cd47 blockade and an immune costimulatory agonist |
UA126549C2 (en) | 2015-10-01 | 2022-11-02 | Хіт Байолоджикс, Інк. | Compositions and methods for adjoining type i and type ii extracellular domains as heterologous chimeric proteins |
KR102472087B1 (en) | 2016-01-11 | 2022-11-29 | 포티 세븐, 인코포레이티드 | Humanized, mouse or chimeric anti-CD47 monoclonal antibody |
US11560433B2 (en) | 2016-05-27 | 2023-01-24 | Albert Einstein College Of Medicine | Methods of treatment by targeting VCAM1 and MAEA |
KR102050463B1 (en) | 2016-08-10 | 2019-11-29 | 아주대학교산학협력단 | Heterodimeric Fc-fused cytokine and pharmaceutical composition comprising the same |
US11566060B2 (en) | 2017-01-05 | 2023-01-31 | Kahr Medical Ltd. | PD1-CD70 fusion protein and methods of use thereof |
WO2018127918A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A sirp alpha-cd70 fusion protein and methods of use thereof |
SI3565828T1 (en) | 2017-01-05 | 2022-04-29 | Kahr Medical Ltd. | A sirp1 alpha-41bbl fusion protein and methods of use thereof |
WO2018127917A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A pd1-41bbl fusion protein and methods of use thereof |
JP7476467B2 (en) | 2017-02-06 | 2024-05-01 | オリオンズ バイオサイエンス ビーブイ | Targeted chimeric proteins and uses thereof |
SG11201906464UA (en) | 2017-02-27 | 2019-08-27 | Shattuck Labs Inc | Csf1r-based chimeric proteins |
CA3054127A1 (en) | 2017-02-27 | 2018-08-30 | Shattuck Labs, Inc. | Tigit- and light-based chimeric proteins |
US20200157179A1 (en) * | 2017-03-28 | 2020-05-21 | Trillium Therapeutics Inc. | Cd47 blockade therapy |
CN108864290B (en) * | 2017-05-08 | 2021-12-07 | 上海津曼特生物科技有限公司 | Bispecific recombinant protein and application thereof |
US11530247B2 (en) * | 2017-06-06 | 2022-12-20 | Relinia, Inc. | Single-chain TNF receptor 2 agonist fusion proteins |
US11529425B2 (en) | 2017-09-07 | 2022-12-20 | Dingfu Biotarget Co., Ltd. | Immunoconjugates comprising signal regulatory protein alpha |
BR112020010020A2 (en) * | 2017-11-20 | 2020-11-10 | Taizhou Mabtech Pharmaceutical Co., Ltd | a bifunctional fusion protein targeting cd47 and pd-l1 |
MX2020005792A (en) | 2017-12-04 | 2020-11-06 | Beijing Hanmi Pharmaceutical Co Ltd | Anti-pd-l1/anti-cd47 bispecific antibody with structure like natural antibody and in form of heterodimer and preparation thereof. |
CN109971716B (en) * | 2017-12-28 | 2023-08-01 | 上海细胞治疗研究院 | EGFR-specific CAR-T cells from autocrine CD47 antibodies and uses thereof |
ES2927305T3 (en) | 2018-02-12 | 2022-11-04 | Forty Seven Inc | Cancer regimen using anti-CD47 and anti-CD20 antibodies |
EP3765080A4 (en) * | 2018-03-13 | 2022-03-16 | Trillium Therapeutics Inc. | Improvements in cd47 blockade therapy by egfr antibody |
CN111836647A (en) * | 2018-03-13 | 2020-10-27 | 延龄草治疗公司 | Combination of CD47 blocking therapy and CD38 antibody |
CN110386984B (en) * | 2018-04-17 | 2022-04-22 | 杭州尚健生物技术有限公司 | Fusion protein combined with CD47 protein and application thereof |
US20210221908A1 (en) * | 2018-06-03 | 2021-07-22 | Lamkap Bio Beta Ltd. | Bispecific antibodies against ceacam5 and cd47 |
CN112543773B (en) * | 2018-07-11 | 2024-05-31 | 卡尔医学有限公司 | SIRP alpha-4-1 BBL variant fusion proteins and methods of use thereof |
US10780121B2 (en) | 2018-08-29 | 2020-09-22 | Shattuck Labs, Inc. | FLT3L-based chimeric proteins |
EP3843772A2 (en) | 2018-08-31 | 2021-07-07 | ALX Oncology Inc. | Decoy polypeptides |
US11591390B2 (en) | 2018-09-27 | 2023-02-28 | Celgene Corporation | SIRP-α binding proteins and methods of use thereof |
CN109306017B (en) * | 2018-10-12 | 2021-02-09 | 倍而达药业(苏州)有限公司 | Recombinant protein prepared based on SIRP-alpha D1 mutant and application thereof |
AU2019366956A1 (en) | 2018-10-23 | 2021-05-20 | Dragonfly Therapeutics, Inc. | Heterodimeric Fc-fused proteins |
EP3876977A1 (en) | 2018-11-06 | 2021-09-15 | The Regents Of The University Of California | Chimeric antigen receptors for phagocytosis |
CN111303293B (en) * | 2018-11-14 | 2022-08-30 | 杭州尚健生物技术有限公司 | Fusion protein and application thereof |
CN109517054B (en) * | 2018-12-04 | 2022-04-08 | 江苏东抗生物医药科技有限公司 | SIRP alpha variant or fusion protein thereof and application thereof |
EP3936526A4 (en) * | 2019-03-06 | 2023-03-08 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Bifunctional fusion protein and pharmaceutical use thereof |
EP3948281A1 (en) * | 2019-03-29 | 2022-02-09 | F. Hoffmann-La Roche AG | Spr-based binding assay for the functional analysis of multivalent molecules |
CN111763261B (en) * | 2019-04-02 | 2022-08-09 | 杭州尚健生物技术有限公司 | Fusion protein and application thereof |
US11013764B2 (en) | 2019-04-30 | 2021-05-25 | Myeloid Therapeutics, Inc. | Engineered phagocytic receptor compositions and methods of use thereof |
US11613564B2 (en) * | 2019-05-31 | 2023-03-28 | ALX Oncology Inc. | Methods of treating cancer |
CA3142738A1 (en) * | 2019-06-05 | 2020-12-10 | Asher Biotherapeutics, Inc. | Fusions of mutant interleukin-2 polypeptides with antigen binding molecules for modulating immune cell function |
EP3980747A1 (en) | 2019-06-07 | 2022-04-13 | ALX Oncology Inc. | Methods and reagents for reducing the interference of drugs that bind cd47 in serological assays |
CN112125975B (en) * | 2019-06-25 | 2024-03-01 | 上海翰森生物医药科技有限公司 | PD-L1 and CD47 bispecific fusion protein and medical application thereof |
KR20220047277A (en) | 2019-07-16 | 2022-04-15 | 길리애드 사이언시즈, 인코포레이티드 | HIV Vaccines, and Methods of Making and Using the Same |
KR102228271B1 (en) * | 2019-07-16 | 2021-03-17 | 한국과학기술연구원 | immune regulatory protein-siRNA complex for anticancer activity |
MX2022002613A (en) | 2019-09-03 | 2022-06-02 | Myeloid Therapeutics Inc | Methods and compositions for genomic integration. |
AU2020365113A1 (en) | 2019-10-18 | 2022-04-07 | Forty Seven, Inc. | Combination therapies for treating myelodysplastic syndromes and acute myeloid leukemia |
KR20220091576A (en) | 2019-10-31 | 2022-06-30 | 포티 세븐, 인코포레이티드 | Anti-CD47 and Anti-CD20 Based Treatment of Hematological Cancers |
AU2020394204A1 (en) | 2019-11-27 | 2022-06-02 | ALX Oncology Inc. | Combination therapies for treating cancer |
US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
CN117736207A (en) | 2019-12-24 | 2024-03-22 | 卡尔那生物科学株式会社 | Diacylglycerol kinase modulating compounds |
US20230076768A1 (en) | 2020-01-14 | 2023-03-09 | Synthekine, Inc. | IL2 Orthologs and Methods of Use |
CR20220396A (en) | 2020-02-14 | 2022-11-14 | Jounce Therapeutics Inc | Antibodies and fusion proteins that bind to ccr8 and uses thereof |
CN111253482B (en) * | 2020-02-18 | 2021-11-30 | 中国人民解放军军事科学院军事医学研究院 | SIRPa variants, fusion proteins, and uses thereof |
MX2022014784A (en) * | 2020-06-01 | 2023-01-16 | Alx Oncology Inc | Combination therapies comprising a hypomethylation agent for treating cancer. |
KR20230015957A (en) * | 2020-06-30 | 2023-01-31 | 하버 바이오메드 유에스, 아이엔씨. | Bispecific Antibodies and Uses Thereof |
WO2022010806A1 (en) | 2020-07-06 | 2022-01-13 | ALX Oncology Inc. | Methods for reducing the interference of drugs that bind therapeutic targets expressed on blood cells in serological assays |
CN111808183B (en) * | 2020-07-25 | 2022-07-08 | 北京吉尔麦迪生物医药科技有限公司 | High-affinity SIRP alpha mutant targeting CD47 and fusion protein thereof |
CN114057888A (en) * | 2020-07-30 | 2022-02-18 | 三生国健药业(上海)股份有限公司 | SIRP alpha-Fc fusion protein |
CN116390768B (en) * | 2020-08-14 | 2024-07-09 | 韩国科学技术研究院 | Immunomodulatory protein-siRNA complexes with anti-cancer activity |
KR102557016B1 (en) * | 2020-09-22 | 2023-07-20 | 비피진 주식회사 | CD47 binder and liposome complex for treatment cancer |
KR102579284B1 (en) * | 2020-09-22 | 2023-09-18 | 비피진 주식회사 | Liposome complex for treatment cancer comprising new CD47 binder and polynucleotide |
EP4232071A1 (en) | 2020-10-23 | 2023-08-30 | Asher Biotherapeutics, Inc. | Fusions with cd8 antigen binding molecules for modulating immune cell function |
WO2022098905A2 (en) | 2020-11-04 | 2022-05-12 | Myeloid Therapeutics, Inc. | Engineered chimeric fusion protein compositions and methods of use thereof |
US20220196651A1 (en) | 2020-12-06 | 2022-06-23 | ALX Oncology Inc. | Multimers for reducing the interference of drugs that bind cd47 in serological assays |
CN112979782B (en) * | 2021-03-08 | 2023-07-18 | 深圳市乐土生物医药有限公司 | Polypeptide and application thereof |
WO2022190058A1 (en) | 2021-03-12 | 2022-09-15 | Dcprime B.V. | Methods of vaccination and use of cd47 blockade |
TW202302145A (en) | 2021-04-14 | 2023-01-16 | 美商基利科學股份有限公司 | Co-inhibition of cd47/sirpα binding and nedd8-activating enzyme e1 regulatory subunit for the treatment of cancer |
CA3216908A1 (en) * | 2021-05-13 | 2022-11-17 | ALX Oncology Inc. | Combination therapies for treating cancer |
WO2022271684A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
CA3222439A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
AU2022297367A1 (en) | 2021-06-23 | 2023-12-07 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
WO2022271677A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
KR20230016152A (en) * | 2021-07-19 | 2023-02-01 | 주식회사유한양행 | Sirp-alpha variants and use thereof |
CN113896802A (en) * | 2021-10-09 | 2022-01-07 | 宜明昂科生物医药技术(上海)有限公司 | Recombinant fusion protein targeting CD47 and CD38, and preparation and application thereof |
AU2022375782A1 (en) | 2021-10-28 | 2024-05-02 | Gilead Sciences, Inc. | Pyridizin-3(2h)-one derivatives |
CN118201941A (en) | 2021-10-29 | 2024-06-14 | 吉利德科学公司 | CD73 compounds |
CN118139874A (en) * | 2021-11-01 | 2024-06-04 | 山东先声生物制药有限公司 | SIRPa mutant and application thereof |
WO2023092089A1 (en) | 2021-11-19 | 2023-05-25 | Kist (Korea Institute Of Science And Technology) | Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a target cell |
CN116178561A (en) * | 2021-11-26 | 2023-05-30 | 杭州尚健生物技术有限公司 | Fusion proteins comprising SIRPalpha mutants |
TW202334191A (en) * | 2021-11-19 | 2023-09-01 | 大陸商杭州尚健生物技術有限公司 | SIRPα MUTANT AND USE THEREOF |
CA3237577A1 (en) | 2021-12-22 | 2023-06-29 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
US20240124412A1 (en) | 2021-12-22 | 2024-04-18 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
KR20230105583A (en) * | 2022-01-04 | 2023-07-11 | 비피진 주식회사 | Polynucleotide for treatment cancer encoding 5'-nucleotidase modified protein |
TW202340168A (en) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Parp7 inhibitors |
WO2023154578A1 (en) | 2022-02-14 | 2023-08-17 | Sana Biotechnology, Inc. | Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells |
WO2023178181A1 (en) | 2022-03-17 | 2023-09-21 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
WO2023183313A1 (en) | 2022-03-22 | 2023-09-28 | Sana Biotechnology, Inc. | Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods |
US20230365648A1 (en) | 2022-03-24 | 2023-11-16 | Bitterroot Bio, Inc. | Sirp-alpha fusion polypeptides with modified fc domains |
US20230355796A1 (en) | 2022-03-24 | 2023-11-09 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
WO2023183890A1 (en) | 2022-03-24 | 2023-09-28 | Bitterroot Bio, Inc. | Multivalent sirp-alpha fusion polypeptides |
TW202345901A (en) | 2022-04-05 | 2023-12-01 | 美商基利科學股份有限公司 | Combination therapy for treating colorectal cancer |
WO2023205719A1 (en) | 2022-04-21 | 2023-10-26 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
TW202400650A (en) | 2022-05-11 | 2024-01-01 | 日商第一三共股份有限公司 | Combination of an antibody and cd47 inhibitor |
US20240010701A1 (en) | 2022-06-01 | 2024-01-11 | ALX Oncology Inc. | Combination therapies for treating urothelial carcinoma |
WO2024006929A1 (en) | 2022-07-01 | 2024-01-04 | Gilead Sciences, Inc. | Cd73 compounds |
WO2024015741A1 (en) | 2022-07-12 | 2024-01-18 | Gilead Sciences, Inc. | Hiv immunogenic polypeptides and vaccines and uses thereof |
KR20240034954A (en) * | 2022-09-07 | 2024-03-15 | 주식회사 시프트바이오 | Antibody specifically binding to SIRPα variant |
WO2024064668A1 (en) | 2022-09-21 | 2024-03-28 | Gilead Sciences, Inc. | FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY |
WO2024137852A1 (en) | 2022-12-22 | 2024-06-27 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
Family Cites Families (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
US5697901A (en) | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
JPH04334377A (en) | 1990-12-31 | 1992-11-20 | Akzo Nv | Acid-instable linker molecule |
US6613332B1 (en) | 1991-06-21 | 2003-09-02 | The University Of Cincinnati | Oral administration of therapeutic proteins |
EP0590060B1 (en) | 1991-06-21 | 1997-09-17 | University Of Cincinnati | Orally administrable therapeutic proteins and method of making |
IL99120A0 (en) | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
EP0861893A3 (en) | 1991-09-19 | 1999-11-10 | Genentech, Inc. | High level expression of immunoglobulin polypeptides |
US5505931A (en) | 1993-03-04 | 1996-04-09 | The Dow Chemical Company | Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
EP0840797B1 (en) | 1995-07-25 | 2014-09-03 | Crucell Holland B.V. | Methods and means for targeted gene delivery |
US6321109B2 (en) | 1996-02-15 | 2001-11-20 | Biosense, Inc. | Catheter based surgery |
JP2000514440A (en) | 1996-07-09 | 2000-10-31 | ザ ジョーンズ ホプキンス ユニバーシティー | Gene transfer system |
US6541615B1 (en) | 1996-11-15 | 2003-04-01 | Max-Planck-Gellschaft Zur Foderung Der Wissenschaften E.V. | SIRP proteins and uses thereof |
CA2226962A1 (en) | 1998-02-16 | 1999-08-16 | Marie Sarfati | Use of binding agents to cd47 and its ligands in the treatment or the prophylaxis of various inflammatory, autoimmune and allergic diseases and in the treatment of graft rejection |
WO2000077026A1 (en) | 1999-06-11 | 2000-12-21 | Human Genome Sciences, Inc. | 49 human secreted proteins |
US6613026B1 (en) | 1999-12-08 | 2003-09-02 | Scimed Life Systems, Inc. | Lateral needle-less injection apparatus and method |
GB9930706D0 (en) | 1999-12-24 | 2000-02-16 | Medical Res Council | Composition for inhibiting macrophage activity |
US7662367B2 (en) | 2000-03-02 | 2010-02-16 | Xencor, Inc. | Pharmaceutical compositions for the treatment of TNF-α related disorders |
TWI334439B (en) | 2001-08-01 | 2010-12-11 | Centocor Inc | Anti-tnf antibodies, compositions, methods and uses |
GB0124145D0 (en) | 2001-10-08 | 2001-11-28 | Bayer Ag | Genes and proteins for prevention,prediction,prognosis and therapy of cardiovascular disease |
US20040018522A1 (en) | 2002-05-09 | 2004-01-29 | Brigham And Women's Hospital, Inc. | Identification of dysregulated genes in patients with multiple sclerosis |
WO2004011618A2 (en) | 2002-07-29 | 2004-02-05 | Hmgene, Inc. | Methods of identifying adipocyte specific genes, the genes identified, and their uses |
EP2444409A2 (en) | 2002-09-16 | 2012-04-25 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
JP2006520584A (en) | 2002-11-08 | 2006-09-14 | アブリンクス エン.ヴェー. | Stabilized single domain antibody |
US8613922B2 (en) | 2003-04-24 | 2013-12-24 | The University Of North Carolina At Chapel Hill | Methods for inhibiting diabetic retinopathy with an antibody against integrin associated protein (IAP) |
US20040213792A1 (en) | 2003-04-24 | 2004-10-28 | Clemmons David R. | Method for inhibiting cellular activation by insulin-like growth factor-1 |
US20100215640A1 (en) | 2003-04-24 | 2010-08-26 | The University Of North Carolina At Chapel Hill | Method for inhibiting cellular activation by insulin-like growth factor-1 |
EP1658308A1 (en) | 2003-08-25 | 2006-05-24 | Pieris ProteoLab AG | Muteins of a bilin-binding protein with affinity for a given target |
MXPA06009805A (en) | 2004-02-27 | 2007-04-02 | Vaxconsulting | Peptides of il1 beta and tnf alpha and method of treatment using same. |
WO2005092362A2 (en) | 2004-03-29 | 2005-10-06 | Hallstroem Seth | Pharmaceutical combined preparation containing a therapeutic protein |
US20080299042A1 (en) | 2004-04-30 | 2008-12-04 | Biogen Idec Ma Inc. | Membrane Associated Molecules |
US7514229B2 (en) | 2005-09-29 | 2009-04-07 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for diagnosing and evaluating treatment of blood disorders |
AR060017A1 (en) | 2006-01-13 | 2008-05-21 | Novartis Ag | COMPOSITIONS AND METHODS OF USE FOR DICKKOPF -1 ANTIBODIES |
US8377448B2 (en) | 2006-05-15 | 2013-02-19 | The Board Of Trustees Of The Leland Standford Junior University | CD47 related compositions and methods for treating immunological diseases and disorders |
WO2008131242A1 (en) | 2007-04-18 | 2008-10-30 | Zymogenetics, Inc. | Single chain fc, methods of making and methods of treatment |
RU2009140134A (en) * | 2007-04-23 | 2011-05-27 | Вайет (Us) | METHODS AND COMPOSITIONS FOR TREATMENT AND MONITORING TREATMENT OF IL-13 RELATED DISORDERS |
WO2009025846A2 (en) | 2007-08-22 | 2009-02-26 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
EP2388270A3 (en) | 2007-10-11 | 2012-04-25 | The Hospital For Sick Children | Modulation of SIRPa - CD47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor |
JP6157046B2 (en) | 2008-01-07 | 2017-07-05 | アムジェン インコーポレイテッド | Method for generating antibody Fc heterodimer molecules using electrostatic steering effect |
AU2009205665B2 (en) | 2008-01-15 | 2013-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for manipulating phagocytosis mediated by CD47 |
EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
WO2010070047A1 (en) * | 2008-12-19 | 2010-06-24 | Novartis Ag | Soluble polypeptides for use in treating autoimmune and inflammatory disorders |
WO2010081173A2 (en) | 2009-01-12 | 2010-07-15 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
AU2010215761B2 (en) | 2009-02-23 | 2017-04-06 | Cytomx Therapeutics, Inc | Proproteins and methods of use thereof |
CA2761438C (en) | 2009-05-15 | 2017-12-12 | University Health Network | Compositions and methods for treating hematologic cancers targeting the sirp.alpha.-cd47 interaction |
TWI557224B (en) | 2009-07-20 | 2016-11-11 | 國立成功大學 | Polypeptides selective for αvβ3 integrin conjugated with a variant of human serum albumin (hsa) and pharmaceutical uses thereof |
KR101632312B1 (en) | 2009-11-03 | 2016-06-21 | 삼성전자주식회사 | Fusion protein binding specifically to constant region of antibody, preparation thereof and method for isolating antibody using the same |
ES2751549T3 (en) * | 2009-11-30 | 2020-04-01 | Janssen Biotech Inc | Fc antibody mutants with ablated effector functions |
US20130011401A1 (en) | 2009-12-22 | 2013-01-10 | Novartis Ag | Soluble proteins for use as therapeutics |
PT2569013T (en) | 2010-05-14 | 2017-02-08 | Univ Leland Stanford Junior | Humanized and chimeric monoclonal antibodies to cd47 |
KR102005562B1 (en) | 2010-10-08 | 2019-07-30 | 시티 오브 호프 | A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use |
US8609621B2 (en) | 2010-11-15 | 2013-12-17 | E I Du Pont De Nemours And Company | Acid-cleavable linkers exhibiting altered rates of acid hydrolysis |
WO2012109267A2 (en) | 2011-02-07 | 2012-08-16 | The Trustees Of The University Of Pennsylvania | Novel peptides and methods using same |
PT2691417T (en) | 2011-03-29 | 2018-10-31 | Roche Glycart Ag | Antibody fc variants |
HUE033008T2 (en) * | 2011-04-13 | 2017-11-28 | Bristol Myers Squibb Co | Fc fusion proteins comprising novel linkers or arrangements |
WO2012145714A2 (en) * | 2011-04-22 | 2012-10-26 | Emergent Product Development Seattle, Llc | Prostate-specific membrane antigen binding proteins and related compositions and methods |
AU2012269929A1 (en) | 2011-06-16 | 2013-12-12 | Novartis Ag | Soluble proteins for use as therapeutics |
US20140242095A1 (en) | 2011-10-19 | 2014-08-28 | University Health Network | Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers |
WO2013063076A1 (en) | 2011-10-25 | 2013-05-02 | Indiana University Research & Technology Corporation | Compositions for and methods of modulating complications, risks and issues with xenotransplantation |
US9944911B2 (en) * | 2012-01-17 | 2018-04-17 | The Board Of Trustees Of The Leland Stanford Junior University | High affinity Sirp-alpha reagents and methods of using |
US9428553B2 (en) | 2012-02-10 | 2016-08-30 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
EP2863948B1 (en) | 2012-06-22 | 2018-10-24 | Cytomx Therapeutics Inc. | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
US9856314B2 (en) | 2012-06-22 | 2018-01-02 | Cytomx Therapeutics, Inc. | Activatable antibodies having non-binding steric moieties and methods of using the same |
GB201216649D0 (en) | 2012-09-18 | 2012-10-31 | Univ Birmingham | Agents and methods |
CA2894245C (en) | 2012-12-17 | 2022-03-22 | Trillium Therapeutics Inc. | Treatment of cd47+ disease cells with sirp alpha-fc fusions |
US9873747B2 (en) | 2013-01-31 | 2018-01-23 | Thomas Jefferson University | Fusion proteins that facilitate cancer cell destruction |
CA2900256C (en) | 2013-02-05 | 2023-03-21 | Kim J. HASENKRUG | Cd47 targeted therapies for the treatment of infectious disease |
US11285169B2 (en) | 2013-03-13 | 2022-03-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for modulating chemotherapeutic cytotoxicity |
EP2970493B1 (en) | 2013-03-15 | 2019-04-03 | The Board of Trustees of the Leland Stanford Junior University | Methods for achieving therapeutically effective doses of anti-cd47 agents |
US10064925B2 (en) | 2013-04-29 | 2018-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Use of anti-CD47 agents to enhance immunization |
WO2014186761A2 (en) | 2013-05-17 | 2014-11-20 | The Board Of Trustes Of The Leland Stanford Junior University | Methods for determining responsiveness to an anti-cd47 agent |
EP3027647A4 (en) * | 2013-07-31 | 2017-01-04 | Amgen Inc. | Stabilization of fc-containing polypeptides |
US10329354B2 (en) | 2013-09-18 | 2019-06-25 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of efferocytosis pathways for treatment of atherosclerotic disease |
US9193977B2 (en) | 2013-09-23 | 2015-11-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized signal-regulatory protein gene |
NZ718283A (en) | 2013-09-25 | 2022-05-27 | Cytomx Therapeutics Inc | Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof |
KR102339240B1 (en) * | 2013-10-15 | 2021-12-15 | 더 스크립스 리서치 인스티튜트 | Peptidic chimeric antigen receptor t cell switches and uses thereof |
AU2015210862B2 (en) | 2014-01-31 | 2020-04-23 | Cytomx Therapeutics, Inc | Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof |
US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
US10144778B2 (en) | 2014-03-12 | 2018-12-04 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
WO2016023001A1 (en) | 2014-08-08 | 2016-02-11 | The Board Of Trustees Of The Leland Stanford Junior University | Multispecific high affinity pd-1 agents and methods of use |
US10800830B2 (en) | 2014-08-08 | 2020-10-13 | The Board Of Trustees Of The Leland Stanford Junior University | High affinity PD-1 agents and methods of use |
EP4321171A3 (en) | 2014-08-08 | 2024-05-15 | The Board of Trustees of the Leland Stanford Junior University | Sirp alpha-antibody fusion proteins |
CN106535914B (en) | 2014-08-08 | 2021-08-27 | Alx 肿瘤生物技术公司 | SIRP-alpha variant constructs and uses thereof |
AU2015303135B2 (en) | 2014-08-15 | 2021-05-20 | Merck Patent Gmbh | SIRP-alpha immunoglobulin fusion proteins |
PL3186395T5 (en) | 2014-08-26 | 2023-06-12 | The Board Of Trustees Of The Leland Stanford Junior University | Engraftment of stem cells with a combination of an agent that targets stem cells and modulation of immunoregulatory signaling |
US10822411B2 (en) | 2014-09-15 | 2020-11-03 | The Board Of Trustees Of The Leland Stanford Junior University | Targeting aneurysm disease by modulating phagocytosis pathways |
AU2015329696A1 (en) | 2014-10-10 | 2017-04-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods to eliminate cancer stem cells by targeting CD47 |
CA2959821A1 (en) | 2014-10-24 | 2016-04-28 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for inducing phagocytosis of mhc class i positive cells and countering anti-cd47/sirpa resistance |
EP3012271A1 (en) | 2014-10-24 | 2016-04-27 | Effimune | Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases |
BR112017010303A2 (en) | 2014-11-18 | 2018-05-15 | Janssen Pharmaceutica Nv | cd47 antibodies, methods and uses |
EP3811972B1 (en) | 2015-02-27 | 2023-01-11 | The Board of Trustees of the Leland Stanford Junior University | Combination therapy for treatment of atherosclerosis |
CN106146670B (en) | 2015-04-24 | 2019-01-15 | 宜明昂科生物医药技术(上海)有限公司 | A kind of new recombination double functions fusion protein and its preparation and application |
CN117964732A (en) | 2015-08-07 | 2024-05-03 | Alx肿瘤生物技术公司 | Constructs with SIRP-alpha domains or variants thereof |
CN109071664B (en) | 2016-04-14 | 2023-02-21 | Ose免疫疗法 | Novel anti-SIRPa antibodies and therapeutic uses thereof |
JOP20190009A1 (en) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | Antibodies against signal-regulatory protein alpha and methods of use |
US11613564B2 (en) | 2019-05-31 | 2023-03-28 | ALX Oncology Inc. | Methods of treating cancer |
EP3980747A1 (en) | 2019-06-07 | 2022-04-13 | ALX Oncology Inc. | Methods and reagents for reducing the interference of drugs that bind cd47 in serological assays |
AU2020394204A1 (en) | 2019-11-27 | 2022-06-02 | ALX Oncology Inc. | Combination therapies for treating cancer |
MX2022014784A (en) | 2020-06-01 | 2023-01-16 | Alx Oncology Inc | Combination therapies comprising a hypomethylation agent for treating cancer. |
WO2022010806A1 (en) | 2020-07-06 | 2022-01-13 | ALX Oncology Inc. | Methods for reducing the interference of drugs that bind therapeutic targets expressed on blood cells in serological assays |
US20220196651A1 (en) | 2020-12-06 | 2022-06-23 | ALX Oncology Inc. | Multimers for reducing the interference of drugs that bind cd47 in serological assays |
CA3216908A1 (en) | 2021-05-13 | 2022-11-17 | ALX Oncology Inc. | Combination therapies for treating cancer |
-
2016
- 2016-08-05 CN CN202410176664.7A patent/CN117964732A/en active Pending
- 2016-08-05 RS RS20210912A patent/RS62151B1/en unknown
- 2016-08-05 CN CN201680057835.8A patent/CN108350048B/en active Active
- 2016-08-05 US US15/230,186 patent/US10259859B2/en active Active
- 2016-08-05 UA UAA201802321A patent/UA125638C2/en unknown
- 2016-08-05 SI SI201631278T patent/SI3331902T1/en unknown
- 2016-08-05 PT PT168357234T patent/PT3331902T/en unknown
- 2016-08-05 EP EP16835723.4A patent/EP3331902B1/en active Active
- 2016-08-05 KR KR1020187006473A patent/KR20180028548A/en not_active Application Discontinuation
- 2016-08-05 JP JP2018506281A patent/JP6898303B2/en active Active
- 2016-08-05 GE GEAP201614720A patent/GEP20217326B/en unknown
- 2016-08-05 DK DK16835723.4T patent/DK3331902T3/en active
- 2016-08-05 IL IL302491A patent/IL302491A/en unknown
- 2016-08-05 PE PE2018000186A patent/PE20180778A1/en unknown
- 2016-08-05 AU AU2016304794A patent/AU2016304794B2/en active Active
- 2016-08-05 LT LTEP16835723.4T patent/LT3331902T/en unknown
- 2016-08-05 IL IL256989A patent/IL256989B/en unknown
- 2016-08-05 GE GEAP201615294A patent/GEP20227447B/en unknown
- 2016-08-05 RU RU2018108103A patent/RU2740672C2/en active
- 2016-08-05 EP EP21163641.0A patent/EP3913051A1/en active Pending
- 2016-08-05 MY MYPI2018000181A patent/MY185014A/en unknown
- 2016-08-05 ES ES16835723T patent/ES2881771T3/en active Active
- 2016-08-05 NZ NZ738950A patent/NZ738950A/en unknown
- 2016-08-05 RU RU2020143675A patent/RU2020143675A/en unknown
- 2016-08-05 BR BR112018001353-6A patent/BR112018001353A2/en active Search and Examination
- 2016-08-05 CN CN202311337928.4A patent/CN117777267A/en active Pending
- 2016-08-05 SG SG10202101909RA patent/SG10202101909RA/en unknown
- 2016-08-05 PL PL16835723T patent/PL3331902T3/en unknown
- 2016-08-05 SG SG10201912905VA patent/SG10201912905VA/en unknown
- 2016-08-05 HU HUE16835723A patent/HUE055139T2/en unknown
- 2016-08-05 WO PCT/US2016/045914 patent/WO2017027422A1/en active Application Filing
- 2016-08-05 IL IL294679A patent/IL294679B2/en unknown
- 2016-08-05 MX MX2018001428A patent/MX2018001428A/en unknown
- 2016-08-05 CA CA2993835A patent/CA2993835A1/en active Pending
-
2018
- 2018-02-01 MX MX2022010803A patent/MX2022010803A/en unknown
- 2018-02-05 PH PH12018500269A patent/PH12018500269A1/en unknown
- 2018-02-06 CL CL2018000340A patent/CL2018000340A1/en unknown
- 2018-02-06 SA SA518390881A patent/SA518390881B1/en unknown
- 2018-02-09 ZA ZA2018/00857A patent/ZA201800857B/en unknown
- 2018-03-06 CO CONC2018/0002471A patent/CO2018002471A2/en unknown
- 2018-10-05 US US16/153,404 patent/US10696730B2/en active Active
- 2018-12-25 HK HK18116580.2A patent/HK1257372A1/en unknown
-
2020
- 2020-01-07 US US16/736,651 patent/US11639376B2/en active Active
- 2020-02-05 ZA ZA2020/00743A patent/ZA202000743B/en unknown
- 2020-03-04 CL CL2020000531A patent/CL2020000531A1/en unknown
- 2020-03-04 CL CL2020000530A patent/CL2020000530A1/en unknown
- 2020-03-20 US US16/825,850 patent/US11208459B2/en active Active
- 2020-03-24 ZA ZA2020/01863A patent/ZA202001863B/en unknown
- 2020-12-11 JP JP2020205966A patent/JP2021063082A/en active Pending
-
2021
- 2021-07-21 HR HRP20211167TT patent/HRP20211167T1/en unknown
- 2021-07-26 CY CY20211100674T patent/CY1124372T1/en unknown
- 2021-08-16 AU AU2021218004A patent/AU2021218004B2/en active Active
-
2023
- 2023-01-26 JP JP2023010460A patent/JP2023061969A/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA202001863B (en) | Constructs having a sirp-alpha domain or variant thereof | |
HUE049290T2 (en) | Decoupler | |
IL273493A (en) | Modified car-t | |
AU201714106S (en) | Mandoline | |
EP3684343C0 (en) | Improved supraparticles | |
GB201612093D0 (en) | Combination | |
IL272526A (en) | Improved endoinulinases | |
IL252511A0 (en) | Light-injecting element | |
PL3113960T3 (en) | Fastening element | |
GB201616014D0 (en) | Combination | |
GB201707210D0 (en) | Improved hitchlock | |
GB201716492D0 (en) | Disclosure | |
GB201715938D0 (en) | Disclosure | |
GB201715756D0 (en) | Disclosure | |
GB201706691D0 (en) | Microcontroller | |
GB201713289D0 (en) | Combination | |
GB201707508D0 (en) | Modified bulgeomers | |
LT3308671T (en) | Broom | |
AP00994S1 (en) | Autorickshaw | |
GB201709193D0 (en) | Combination | |
GB201709567D0 (en) | Chimp | |
GB201703034D0 (en) | Modified bulgeomers | |
GB201706929D0 (en) | Combination | |
GB201621467D0 (en) | Modified bulgeomers | |
GB201616374D0 (en) | Modified bulgeomers |