RU2728412C2 - Животные, отличные от человека, имеющие гуманизированный ген кластера дифференцировки 47 - Google Patents

Животные, отличные от человека, имеющие гуманизированный ген кластера дифференцировки 47 Download PDF

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RU2728412C2
RU2728412C2 RU2017123357A RU2017123357A RU2728412C2 RU 2728412 C2 RU2728412 C2 RU 2728412C2 RU 2017123357 A RU2017123357 A RU 2017123357A RU 2017123357 A RU2017123357 A RU 2017123357A RU 2728412 C2 RU2728412 C2 RU 2728412C2
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human
gene
rodent
polypeptide
humanized
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RU2017123357A3 (enExample
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Каган ГУРЕР
Элла Иоффе
Александер МУЖИКА
Гэвин ТЕРСТОН
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Регенерон Фармасьютикалз, Инк.
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    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
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    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
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    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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RU2017123357A 2014-12-05 2015-11-25 Животные, отличные от человека, имеющие гуманизированный ген кластера дифференцировки 47 RU2728412C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462087992P 2014-12-05 2014-12-05
US62/087,992 2014-12-05
PCT/US2015/062614 WO2016089692A1 (en) 2014-12-05 2015-11-25 Non-human animals having a humanized cluster of differentiation 47 gene

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RU2020121749A Division RU2827833C1 (ru) 2014-12-05 2015-11-25 Животные, отличные от человека, имеющие гуманизированный ген кластера дифференцировки 47

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RU2017123357A RU2017123357A (ru) 2019-01-09
RU2017123357A3 RU2017123357A3 (enExample) 2019-06-03
RU2728412C2 true RU2728412C2 (ru) 2020-07-29

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US (5) US20160345549A1 (enExample)
EP (4) EP3466255B1 (enExample)
JP (2) JP6730277B2 (enExample)
KR (3) KR102617691B1 (enExample)
CN (2) CN107205368B (enExample)
AR (1) AR102888A1 (enExample)
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SI (3) SI3466255T1 (enExample)
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Families Citing this family (32)

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Publication number Priority date Publication date Assignee Title
KR102617691B1 (ko) 2014-12-05 2023-12-27 리제너론 파마슈티칼스 인코포레이티드 인간화 분화 클러스터 47 유전자를 가진 비인간 동물
NZ731954A (en) 2014-12-09 2024-11-29 Regeneron Pharma Non-human animals having a humanized cluster of differentiation 274 gene
WO2016154299A1 (en) * 2015-03-24 2016-09-29 The Trustees Of Columbia University In The City Of New York Genetic modification of pigs for xenotransplantation
RU2725737C2 (ru) 2015-05-29 2020-07-03 Регенерон Фармасьютикалс, Инк. Животные, отличные от человека, с нарушением в локусе c9orf72
AU2016358101B2 (en) 2015-11-20 2022-12-01 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized Lymphocyte-activation gene 3
CN108779159B (zh) 2016-02-04 2022-12-30 瑞泽恩制药公司 具有经改造的angptl8基因的非人动物
JP6980674B2 (ja) 2016-02-29 2021-12-15 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. ヒト化ｔｍｐｒｓｓ遺伝子を有する齧歯類
EP4056031A1 (en) * 2016-08-11 2022-09-14 The Jackson Laboratory Methods and compositions relating to improved human red blood cell survival in genetically modified immunodeficient non-human animals
WO2018041121A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric ctla-4
CN107815468B (zh) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 人源化基因改造动物模型的制备方法及应用
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