MX378943B - ANIMALES NO HUMANOS QUE EXPRESAN SECUENCIAS DE INMUNOGLOBULINA SENSIBLES AL pH. - Google Patents
ANIMALES NO HUMANOS QUE EXPRESAN SECUENCIAS DE INMUNOGLOBULINA SENSIBLES AL pH.Info
- Publication number
- MX378943B MX378943B MX2018005698A MX2018005698A MX378943B MX 378943 B MX378943 B MX 378943B MX 2018005698 A MX2018005698 A MX 2018005698A MX 2018005698 A MX2018005698 A MX 2018005698A MX 378943 B MX378943 B MX 378943B
- Authority
- MX
- Mexico
- Prior art keywords
- histidine
- human animals
- immunoglobulin
- germline
- codon
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261611950P | 2012-03-16 | 2012-03-16 | |
| US201261612126P | 2012-03-16 | 2012-03-16 | |
| US201261613352P | 2012-03-20 | 2012-03-20 | |
| US201261736930P | 2012-12-13 | 2012-12-13 | |
| PCT/US2013/032036 WO2013138712A1 (en) | 2012-03-16 | 2013-03-15 | Non-human animals expressing ph-sensitive immunoglobulin sequences |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX378943B true MX378943B (es) | 2025-03-10 |
Family
ID=48045752
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018005698A MX378943B (es) | 2012-03-16 | 2013-03-15 | ANIMALES NO HUMANOS QUE EXPRESAN SECUENCIAS DE INMUNOGLOBULINA SENSIBLES AL pH. |
| MX2014011048A MX355944B (es) | 2012-03-16 | 2013-03-15 | Animales no humanos que expresan secuencias de inmunoglobulina sensibles al ph. |
| MX2021000484A MX2021000484A (es) | 2012-03-16 | 2014-09-12 | Animales no humanos que expresan secuencias de inmunoglobulina sensibles al ph. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014011048A MX355944B (es) | 2012-03-16 | 2013-03-15 | Animales no humanos que expresan secuencias de inmunoglobulina sensibles al ph. |
| MX2021000484A MX2021000484A (es) | 2012-03-16 | 2014-09-12 | Animales no humanos que expresan secuencias de inmunoglobulina sensibles al ph. |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US9801362B2 (enExample) |
| EP (2) | EP2825037B1 (enExample) |
| JP (4) | JP6228589B2 (enExample) |
| KR (3) | KR102459666B1 (enExample) |
| CN (2) | CN104302171B (enExample) |
| BR (1) | BR112014022855A2 (enExample) |
| CY (1) | CY1121864T1 (enExample) |
| DK (1) | DK2825037T3 (enExample) |
| ES (1) | ES2737990T3 (enExample) |
| HR (1) | HRP20191333T1 (enExample) |
| HU (1) | HUE045537T2 (enExample) |
| IL (4) | IL234237B (enExample) |
| LT (1) | LT2825037T (enExample) |
| MX (3) | MX378943B (enExample) |
| NZ (3) | NZ629077A (enExample) |
| PL (1) | PL2825037T4 (enExample) |
| PT (1) | PT2825037T (enExample) |
| RS (1) | RS59076B1 (enExample) |
| RU (2) | RU2664473C2 (enExample) |
| SG (3) | SG10202107388VA (enExample) |
| SI (1) | SI2825037T1 (enExample) |
| SM (1) | SMT201900535T1 (enExample) |
| WO (1) | WO2013138712A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4793360A2 (en) | 2006-03-31 | 2026-08-19 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
| TW201920257A (zh) | 2008-04-11 | 2019-06-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗原結合分子 |
| TWI654203B (zh) | 2010-11-30 | 2019-03-21 | Chugai Seiyaku Kabushiki Kaisha | 具有鈣依存性的抗原結合能力之抗體 |
| SG10201609665PA (en) | 2011-02-25 | 2017-01-27 | Chugai Pharmaceutical Co Ltd | FcɣRIIb-SPECIFIC Fc ANTIBODY |
| WO2013002362A1 (ja) | 2011-06-30 | 2013-01-03 | 中外製薬株式会社 | ヘテロ二量化ポリペプチド |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| KR20210074395A (ko) | 2011-11-30 | 2021-06-21 | 추가이 세이야쿠 가부시키가이샤 | 면역 복합체를 형성하는 세포내로의 운반체（캐리어）를 포함하는 의약 |
| CA2865158C (en) | 2012-02-24 | 2022-11-01 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for promoting disappearance of antigen via fc.gamma.riib |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| HUE037659T2 (hu) | 2012-03-16 | 2018-09-28 | Regeneron Pharma | Hisztidinmódosított könnyûlánc antitestek és genetikailag módosított rágcsálók ennek az elõállítására |
| US9801362B2 (en) | 2012-03-16 | 2017-10-31 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing pH-sensitive immunoglobulin sequences |
| WO2013138681A1 (en) * | 2012-03-16 | 2013-09-19 | Regeneron Pharmaceuticals, Inc. | Mice that produce antigen-binding proteins with ph-dependent binding characteristics |
| NZ704771A (en) * | 2012-08-13 | 2018-02-23 | Regeneron Pharma | Anti-pcsk9 antibodies with ph-dependent binding characteristics |
| TWI855488B (zh) | 2012-08-24 | 2024-09-11 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| CN105102618B (zh) | 2012-12-27 | 2018-04-17 | 中外制药株式会社 | 异源二聚化多肽 |
| RS57582B1 (sr) * | 2013-02-20 | 2018-11-30 | Regeneron Pharma | Nehumane životinje sa modifikovanim sekvencama imunoglobulinskog teškog lanca |
| SG11201508170TA (en) | 2013-04-02 | 2015-11-27 | Chugai Pharmaceutical Co Ltd | Fc REGION VARIANT |
| US9738702B2 (en) * | 2014-03-14 | 2017-08-22 | Janssen Biotech, Inc. | Antibodies with improved half-life in ferrets |
| EA201791366A1 (ru) | 2014-12-19 | 2018-02-28 | Чугаи Сейяку Кабусики Кайся | Антитела к c5 и способы их применения |
| MX2017005774A (es) | 2014-12-19 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso. |
| US20180016327A1 (en) * | 2015-01-22 | 2018-01-18 | Chugai Seiyaku Kabushiki Kaisha | A Combination of Two or More Anti-C5 Antibodies and Methods of Use |
| CN114773469B (zh) | 2015-02-05 | 2025-12-19 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用 |
| CN107438622A (zh) * | 2015-03-19 | 2017-12-05 | 瑞泽恩制药公司 | 选择结合抗原的轻链可变区的非人动物 |
| EA201792442A1 (ru) | 2015-05-06 | 2018-06-29 | Янссен Байотек, Инк. | Биспецифические агенты, связывающие простатический специфический мембранный антиген (psma), и их применение |
| EP3394098A4 (en) | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | ANTI-MYOSTATIN ANTIBODIES AND METHOD OF USE |
| US20190037816A1 (en) * | 2016-01-13 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | Rodents having an engineered heavy chain diversity region |
| SG10202102885UA (en) | 2016-05-20 | 2021-05-28 | Regeneron Pharma | Methods for breaking immunological tolerance using multiple guide rnas |
| CN109640644B (zh) | 2016-06-03 | 2021-10-26 | 瑞泽恩制药公司 | 表达外源末端脱氧核苷酸转移酶的非人动物 |
| CN116271014A (zh) | 2016-08-05 | 2023-06-23 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| DK3687287T5 (da) * | 2017-09-29 | 2024-08-26 | Regeneron Pharma | Gnavere, udtrykkende humaniseret c1q-kompleks |
| EP4640703A3 (en) | 2017-11-14 | 2026-04-08 | Chugai Seiyaku Kabushiki Kaisha | Anti-c1s antibodies and methods of use |
| EP4534560A3 (en) | 2018-03-24 | 2025-06-11 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| IL277355B2 (en) | 2018-03-26 | 2025-01-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| WO2019190931A1 (en) | 2018-03-26 | 2019-10-03 | Regeneron Pharmaceuticals, Inc. | Anti-pfrh5 antibodies and antigen-binding fragments thereof |
| CN108486126A (zh) * | 2018-03-27 | 2018-09-04 | 重庆金迈博生物科技有限公司 | 一种核酸分子及其在人源化抗体中的应用 |
| EP3807294B1 (en) * | 2018-06-13 | 2026-01-14 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. | Peptides having inhibitory activity on muscarinic receptor m3 |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| MX2021001431A (es) | 2018-08-10 | 2021-05-12 | Chugai Pharmaceutical Co Ltd | Molecula de union al antigeno anti grupo de diferenciacion 137 (cd137) y su uso. |
| CA3137649A1 (en) | 2019-05-15 | 2020-11-19 | Chugai Seiyaku Kabushiki Kaisha | An antigen-binding molecule, a pharmaceutical composition, and a method |
| US20220090060A1 (en) | 2020-09-11 | 2022-03-24 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| EP4262373A1 (en) | 2020-12-16 | 2023-10-25 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| MX2023007401A (es) | 2020-12-23 | 2023-07-06 | Regeneron Pharma | Acidos nucleicos que codifican anticuerpos modificados por anclaje y usos de los mismos. |
| IL319494A (en) * | 2022-09-16 | 2025-05-01 | Biocytogen Pharmaceuticals Beijing Co Ltd | Genetically modified non-human animals and methods for producing heavy chain antibodies |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| US20260123608A1 (en) | 2024-08-06 | 2026-05-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
| WO2026096736A1 (en) | 2024-10-31 | 2026-05-07 | Regeneron Pharmaceuticals, Inc. | Rodents expressing humanized polymeric immunoglobulin receptor |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| CA2075927A1 (en) | 1990-02-16 | 1991-08-17 | Victor A. Raso | Hybrid reagents capable of selectively releasing molecules into cells |
| US6255458B1 (en) * | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US7067284B1 (en) | 1992-01-27 | 2006-06-27 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| ES2301158T3 (es) | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
| US5999908A (en) | 1992-08-06 | 1999-12-07 | Abelow; Daniel H. | Customer-based product design module |
| WO1996034096A1 (en) * | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP0773288A3 (en) | 1995-08-29 | 1997-07-09 | Kirin Brewery | Chimera animal and its method of manufacture |
| JP2007312792A (ja) | 1995-08-29 | 2007-12-06 | Kirin Pharma Co Ltd | キメラ動物およびその作製法 |
| JP3876002B2 (ja) | 1997-04-14 | 2007-01-31 | ミクロメート・アクチエンゲゼルシャフト | 抗ヒト抗原受容体を産生するための斬新な方法およびそれらの使用 |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| EP0979281B1 (en) | 1997-05-02 | 2005-07-20 | Genentech, Inc. | A method for making multispecific antibodies having heteromultimeric and common components |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| AU750453B2 (en) | 1997-10-03 | 2002-07-18 | Chugai Seiyaku Kabushiki Kaisha | Natural human antibody |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| AU9084601A (en) | 2000-09-08 | 2002-03-22 | Massachusetts Inst Technology | G-csf analog compositions and methods |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20060199204A1 (en) | 2001-10-05 | 2006-09-07 | U.S. Epa | Genetic testing for male factor infertility |
| WO2003031656A1 (en) | 2001-10-05 | 2003-04-17 | United States Environmental Protection Agency | Genetic testing for male factor infertility |
| ES2645563T3 (es) | 2001-11-30 | 2017-12-05 | Amgen Fremont Inc. | Animales transgénicos que portan genes de cadena ligera de Ig humana |
| AU2003256266A1 (en) | 2002-06-12 | 2003-12-31 | Genencor International, Inc. | Methods and compositions for milieu-dependent binding of a targeted agent to a target |
| ATE426815T1 (de) | 2002-06-12 | 2009-04-15 | Genencor Int | Verfahren zur verbesserung einer bindungseigenschaft eines molekuls |
| NZ537277A (en) | 2002-07-18 | 2008-04-30 | Crucell Holland Bv | Recombinant production of mixtures of antibodies |
| EP1439234A1 (en) | 2003-01-08 | 2004-07-21 | ARTEMIS Pharmaceuticals GmbH | Targeted transgenesis using the rosa26 locus |
| US8337841B2 (en) | 2003-01-21 | 2012-12-25 | Chugai Seiyaku Kabushiki Kaisha | Methods of screening for antibody light chains |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| MXPA06000562A (es) | 2003-07-15 | 2006-03-30 | Therapeutic Human Polyclonals | Loci de inmunoglobulina humanizada. |
| CN1560081A (zh) | 2004-02-17 | 2005-01-05 | 大连帝恩生物工程有限公司 | 用能产生人IgGl重链－κ轻链小鼠作为制备人源化单克隆抗体和应用 |
| US7276585B2 (en) | 2004-03-24 | 2007-10-02 | Xencor, Inc. | Immunoglobulin variants outside the Fc region |
| US20050260711A1 (en) | 2004-03-30 | 2005-11-24 | Deepshikha Datta | Modulating pH-sensitive binding using non-natural amino acids |
| KR20070084069A (ko) * | 2004-10-08 | 2007-08-24 | 도만티스 리미티드 | Ｔｎｆｒ1에 대한 단일 도메인 항체 및 이의 사용 방법 |
| EP1802193B1 (en) | 2004-10-19 | 2014-04-30 | Regeneron Pharmaceuticals, Inc. | Method for generating a mouse homozygous for a genetic modification |
| JP2008520552A (ja) | 2004-10-22 | 2008-06-19 | メディミューン，インコーポレーテッド | Ｈｍｇｂ１に対する高親和性の抗体およびその使用法 |
| RU2290442C2 (ru) * | 2005-03-21 | 2006-12-27 | Всероссийский государственный научно-исследовательский институт животноводства (ВИЖ) | Способ трансформации стволовых клеток семенников животных in vivo |
| CA3142945A1 (en) * | 2005-03-25 | 2006-10-05 | Regeneron Pharmaceuticals, Inc. | Histidine-buffered formulations of vegf antagonist |
| EP1874817A2 (en) | 2005-04-29 | 2008-01-09 | Innate Pharma | Transgenic animals and methods of making recombinant antibodies |
| WO2007065433A2 (en) | 2005-12-05 | 2007-06-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
| JP5514539B2 (ja) | 2006-03-31 | 2014-06-04 | メダレックス・リミテッド・ライアビリティ・カンパニー | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
| ATE537190T1 (de) | 2006-06-02 | 2011-12-15 | Regeneron Pharma | Hochaffine antikörper gegen den humanen il-6- rezeptor |
| CA2664343C (en) | 2006-10-02 | 2016-04-26 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human il-4 receptor |
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| US20100034194A1 (en) | 2006-10-11 | 2010-02-11 | Siemens Communications Inc. | Eliminating unreachable subscribers in voice-over-ip networks |
| US20100129368A9 (en) * | 2006-10-11 | 2010-05-27 | Ablynx N.V. | Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the pH, compounds comprising the same, and uses thereof |
| RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
| WO2009077483A1 (en) | 2007-12-14 | 2009-06-25 | Novo Nordisk A/S | Antibodies against human nkg2d and uses thereof |
| CA2680613A1 (en) | 2007-03-13 | 2008-09-18 | National Jewish Medical And Research Center | Methods for generation of antibodies |
| ITMI20071522A1 (it) | 2007-07-27 | 2009-01-28 | Areta Internat S R L | Vaccino idiotipico |
| WO2009036379A2 (en) | 2007-09-14 | 2009-03-19 | Adimab, Inc. | Rationally designed, synthetic antibody libraries and uses therefor |
| EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
| BRPI0818865A2 (pt) * | 2007-10-26 | 2015-05-05 | Oklahoma Med Res Found | Anticorpos monoclonais contra proteína c ativada. |
| US8236527B2 (en) * | 2008-03-14 | 2012-08-07 | Humanzyme Limited | Recombinant production of authentic human proteins using human cell expression systems |
| TW201920257A (zh) * | 2008-04-11 | 2019-06-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗原結合分子 |
| EP3456191A1 (en) * | 2008-06-27 | 2019-03-20 | Merus N.V. | Antibody producing non-human mammals |
| TWI445716B (zh) | 2008-09-12 | 2014-07-21 | Rinat Neuroscience Corp | Ｐｃｓｋ９拮抗劑類 |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| PL2346994T3 (pl) | 2008-09-30 | 2022-04-19 | Ablexis, Llc | Myszy knock-in do wytwarzania chimerycznych przeciwciał |
| EP2196476A1 (en) * | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| KR101711222B1 (ko) | 2008-12-18 | 2017-02-28 | 에라스무스 유니버시티 메디컬 센터 로테르담 | 인간화 항체들을 발현하는 비-인간 유전자이식 동물들 및 그의 이용 |
| US8808136B2 (en) | 2009-05-07 | 2014-08-19 | Volvo Construction Equipment Ab | Working machine and a method for operating a working machine |
| NZ596603A (en) | 2009-05-29 | 2013-07-26 | Morphosys Ag | A collection of antibodies or fragments having properties relevant to developability |
| TWI507525B (zh) | 2009-06-26 | 2015-11-11 | Regeneron Pharma | 具天然免疫球蛋白形式之易分離的雙專一性抗體 |
| DK3241435T3 (da) | 2009-07-08 | 2021-08-23 | Kymab Ltd | Dyremodeller og terapeutiske molekyler |
| AU2010271586B2 (en) | 2009-07-16 | 2016-08-11 | Wageningen Universiteit | Regulation of zinc deficiency and tolerance in plants |
| GB2472108B (en) | 2009-08-27 | 2011-07-13 | Budha Singh Dhinjan | Wall bead |
| WO2011072204A1 (en) | 2009-12-10 | 2011-06-16 | Regeneron Pharmaceuticals, Inc. | Mice that make heavy chain antibodies |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US20130185821A1 (en) | 2010-02-08 | 2013-07-18 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| SG183149A1 (en) | 2010-02-08 | 2012-09-27 | Regeneron Pharma | Common light chain mouse |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| NZ602220A (en) | 2010-03-11 | 2014-10-31 | Rinat Neuroscience Corp | Antibodies with ph dependent antigen binding |
| TWI667346B (zh) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
| CN103228130B (zh) | 2010-06-17 | 2016-03-16 | 科马布有限公司 | 动物模型及治疗分子 |
| MY195217A (en) | 2010-06-22 | 2023-01-11 | Regeneron Pharma | MICE Expressing An Immunoglobulin Hybrid Light Chain |
| CN105861548B (zh) | 2011-02-25 | 2020-01-10 | 瑞泽恩制药公司 | Adam6小鼠 |
| ES2872081T3 (es) | 2011-08-05 | 2021-11-02 | Regeneron Pharma | Ratones con cadena ligera universal humanizada |
| CN107287660A (zh) | 2011-09-30 | 2017-10-24 | 中外制药株式会社 | 离子浓度依赖性结合分子文库 |
| GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| JP2015509380A (ja) | 2012-03-06 | 2015-03-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 共通の軽鎖のマウス |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| WO2013138681A1 (en) | 2012-03-16 | 2013-09-19 | Regeneron Pharmaceuticals, Inc. | Mice that produce antigen-binding proteins with ph-dependent binding characteristics |
| US9801362B2 (en) | 2012-03-16 | 2017-10-31 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing pH-sensitive immunoglobulin sequences |
| HUE037659T2 (hu) | 2012-03-16 | 2018-09-28 | Regeneron Pharma | Hisztidinmódosított könnyûlánc antitestek és genetikailag módosított rágcsálók ennek az elõállítására |
| SG10201609535TA (en) | 2012-06-05 | 2017-01-27 | Regeneron Pharma | Methods for making fully human bispecific antibodies using a common light chain |
| US9962404B2 (en) | 2012-09-21 | 2018-05-08 | Reoxcyn Innovation Group, Llc | Cell for electrolyzing a liquid |
| RS57582B1 (sr) | 2013-02-20 | 2018-11-30 | Regeneron Pharma | Nehumane životinje sa modifikovanim sekvencama imunoglobulinskog teškog lanca |
-
2013
- 2013-03-15 US US13/834,129 patent/US9801362B2/en active Active
- 2013-03-15 KR KR1020217042563A patent/KR102459666B1/ko active Active
- 2013-03-15 PT PT13714127T patent/PT2825037T/pt unknown
- 2013-03-15 BR BR112014022855A patent/BR112014022855A2/pt not_active Application Discontinuation
- 2013-03-15 NZ NZ629077A patent/NZ629077A/en not_active IP Right Cessation
- 2013-03-15 NZ NZ730271A patent/NZ730271A/en not_active IP Right Cessation
- 2013-03-15 SG SG10202107388VA patent/SG10202107388VA/en unknown
- 2013-03-15 JP JP2015500651A patent/JP6228589B2/ja active Active
- 2013-03-15 SG SG10201700360VA patent/SG10201700360VA/en unknown
- 2013-03-15 MX MX2018005698A patent/MX378943B/es unknown
- 2013-03-15 CN CN201380025818.2A patent/CN104302171B/zh active Active
- 2013-03-15 SM SM20190535T patent/SMT201900535T1/it unknown
- 2013-03-15 HU HUE13714127A patent/HUE045537T2/hu unknown
- 2013-03-15 EP EP13714127.1A patent/EP2825037B1/en active Active
- 2013-03-15 RS RS20190989A patent/RS59076B1/sr unknown
- 2013-03-15 KR KR1020147025405A patent/KR102213535B1/ko active Active
- 2013-03-15 CN CN201710192722.5A patent/CN107361011B/zh active Active
- 2013-03-15 NZ NZ712508A patent/NZ712508A/en not_active IP Right Cessation
- 2013-03-15 LT LTEP13714127.1T patent/LT2825037T/lt unknown
- 2013-03-15 EP EP19156973.0A patent/EP3539374A1/en active Pending
- 2013-03-15 ES ES13714127T patent/ES2737990T3/es active Active
- 2013-03-15 HR HRP20191333TT patent/HRP20191333T1/hr unknown
- 2013-03-15 SG SG11201405171WA patent/SG11201405171WA/en unknown
- 2013-03-15 SI SI201331533T patent/SI2825037T1/sl unknown
- 2013-03-15 DK DK13714127.1T patent/DK2825037T3/da active
- 2013-03-15 PL PL13714127T patent/PL2825037T4/pl unknown
- 2013-03-15 MX MX2014011048A patent/MX355944B/es active IP Right Grant
- 2013-03-15 RU RU2014141307A patent/RU2664473C2/ru not_active IP Right Cessation
- 2013-03-15 WO PCT/US2013/032036 patent/WO2013138712A1/en not_active Ceased
- 2013-03-15 KR KR1020217003301A patent/KR102345232B1/ko active Active
- 2013-03-15 RU RU2018128915A patent/RU2018128915A/ru not_active Application Discontinuation
- 2013-11-20 US US14/085,424 patent/US9648856B2/en active Active
-
2014
- 2014-08-21 IL IL234237A patent/IL234237B/en active IP Right Grant
- 2014-09-12 MX MX2021000484A patent/MX2021000484A/es unknown
-
2016
- 2016-02-10 IL IL244098A patent/IL244098B/en active IP Right Grant
-
2017
- 2017-05-10 JP JP2017093832A patent/JP6574811B2/ja active Active
- 2017-09-13 US US15/703,490 patent/US11224207B2/en active Active
-
2018
- 2018-08-02 JP JP2018145734A patent/JP7011549B2/ja active Active
-
2019
- 2019-01-21 IL IL264362A patent/IL264362B/en active IP Right Grant
- 2019-08-01 CY CY20191100821T patent/CY1121864T1/el unknown
-
2020
- 2020-04-27 IL IL274268A patent/IL274268B/en unknown
- 2020-10-16 JP JP2020174432A patent/JP2021007409A/ja active Pending
-
2021
- 2021-12-08 US US17/545,099 patent/US12543711B2/en active Active
-
2025
- 2025-12-16 US US19/421,956 patent/US20260107928A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2021000484A (es) | Animales no humanos que expresan secuencias de inmunoglobulina sensibles al ph. | |
| CY1125119T1 (el) | Διαγονιδιακο ζωο ποντικος που παραγει αντισωματα | |
| CY1122036T1 (el) | Μη ανθρωπινα ζωα που εκφραζουν αντισωματα τα οποια εχουν μια κοινη ελαφρια αλυσιδα | |
| MY185881A (en) | Non-human animals with modified immunoglobulin heavy chain sequences | |
| MX2021014818A (es) | Anticuerpos monoclonales anti-cd303. | |
| SI2883449T1 (en) | Light-chain modified antibodies with histidine and genetically modified rodents for their production | |
| CY1121798T1 (el) | Αντισωματα ελαφριων αλυσιδων τροποποιημενων με ιστιδινη και γενετικα τροποποιημενα ζωα πλην του ανθρωπου για τη δημιουργια αυτων | |
| WO2015143414A3 (en) | Non-human animals that make single domain binding proteins | |
| MX2023001793A (es) | Ratones que producen proteinas de union que comprenden dominios vl. | |
| RU2014108208A (ru) | Мыши с гуманизированной универсальной легкой цепью | |
| PE20190108A1 (es) | Moleculas de anticuerpo para el tratamiento del cancer | |
| NZ627977A (en) | Humanized rodents that express heavy chains containing vl domains | |
| MX2021000829A (es) | Animales no humanos humanizados con loci de cadena pesada de inmunoglobulina restringidos. | |
| EP4345163A3 (en) | Genetic engineering of non-human animals for the production of chimeric antibodies | |
| MX353278B (es) | Raton con cadena ligera comun. | |
| TH166794A (th) | สัตว์ที่ไม่ใช่มนุษย์ที่เป็นแบบฮิมแมไนซ์ที่มีโลคัสที่จำกัดของสายหนักของอิมมูโนโกลบูลิน |