MX355944B - Animales no humanos que expresan secuencias de inmunoglobulina sensibles al ph. - Google Patents
Animales no humanos que expresan secuencias de inmunoglobulina sensibles al ph.Info
- Publication number
- MX355944B MX355944B MX2014011048A MX2014011048A MX355944B MX 355944 B MX355944 B MX 355944B MX 2014011048 A MX2014011048 A MX 2014011048A MX 2014011048 A MX2014011048 A MX 2014011048A MX 355944 B MX355944 B MX 355944B
- Authority
- MX
- Mexico
- Prior art keywords
- histidine
- human animals
- immunoglobulin
- germline
- codon
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
Abstract
La presente invención se refiere a animales no humanos genéticamente modificados que expresan un dominio variable de inmunoglobulina que comprende al menos una histidina, en donde la al menos una histidina es codificada por una sustitución de un codón no codificador de histidina de la línea germinal del animal, por un codón de histidina, o la inserción de un codón de histidina en una secuencia de ácido nucleico de inmunoglobulina de la línea germinal. También se proporcionan genes de inmunoglobulina que comprenden histidinas en una o más CDRs, en una región N-terminal, y/o en una región de asa 4. También se proporcionan dominios variables de inmunoglobulina que comprenden una o más histidinas (p. ej., agrupaciones de histidinas) sustituidas por residuos no histidina que no se unen al antígeno. También se proporcionan animales no humanos que son progenie de los animales que comprenden loci variables de cadena pesada modificados (segmentos V, D, J), loci variables de cadena ligera modificados (segmentos V, J), y genes de cadena ligera de línea germinal rearreglados (secuencias VJ). Se proporcionan animales no humanos que producen dominios de inmunoglobulina que se unen a antígenos de manera sensible al pH.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261612126P | 2012-03-16 | 2012-03-16 | |
US201261611950P | 2012-03-16 | 2012-03-16 | |
US201261613352P | 2012-03-20 | 2012-03-20 | |
US201261736930P | 2012-12-13 | 2012-12-13 | |
PCT/US2013/032036 WO2013138712A1 (en) | 2012-03-16 | 2013-03-15 | Non-human animals expressing ph-sensitive immunoglobulin sequences |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014011048A MX2014011048A (es) | 2015-04-10 |
MX355944B true MX355944B (es) | 2018-05-07 |
Family
ID=48045752
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014011048A MX355944B (es) | 2012-03-16 | 2013-03-15 | Animales no humanos que expresan secuencias de inmunoglobulina sensibles al ph. |
MX2021000484A MX2021000484A (es) | 2012-03-16 | 2014-09-12 | Animales no humanos que expresan secuencias de inmunoglobulina sensibles al ph. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021000484A MX2021000484A (es) | 2012-03-16 | 2014-09-12 | Animales no humanos que expresan secuencias de inmunoglobulina sensibles al ph. |
Country Status (24)
Country | Link |
---|---|
US (4) | US9801362B2 (es) |
EP (2) | EP3539374A1 (es) |
JP (4) | JP6228589B2 (es) |
KR (3) | KR102459666B1 (es) |
CN (2) | CN104302171B (es) |
BR (1) | BR112014022855A2 (es) |
CA (1) | CA2865645A1 (es) |
CY (1) | CY1121864T1 (es) |
DK (1) | DK2825037T3 (es) |
ES (1) | ES2737990T3 (es) |
HK (1) | HK1200270A1 (es) |
HR (1) | HRP20191333T1 (es) |
HU (1) | HUE045537T2 (es) |
IL (4) | IL234237B (es) |
LT (1) | LT2825037T (es) |
MX (2) | MX355944B (es) |
NZ (3) | NZ730271A (es) |
PL (1) | PL2825037T4 (es) |
PT (1) | PT2825037T (es) |
RS (1) | RS59076B1 (es) |
RU (2) | RU2018128915A (es) |
SG (3) | SG10201700360VA (es) |
SI (1) | SI2825037T1 (es) |
WO (1) | WO2013138712A1 (es) |
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KR102469853B1 (ko) | 2008-04-11 | 2022-11-22 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
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