JP2021137030A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021137030A5 JP2021137030A5 JP2021099420A JP2021099420A JP2021137030A5 JP 2021137030 A5 JP2021137030 A5 JP 2021137030A5 JP 2021099420 A JP2021099420 A JP 2021099420A JP 2021099420 A JP2021099420 A JP 2021099420A JP 2021137030 A5 JP2021137030 A5 JP 2021137030A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- gene
- mouse
- antigen
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022191963A JP7525579B2 (ja) | 2012-02-01 | 2022-11-30 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2023173593A JP2023168590A (ja) | 2012-02-01 | 2023-10-05 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261593463P | 2012-02-01 | 2012-02-01 | |
| US61/593,463 | 2012-02-01 | ||
| US201261677538P | 2012-07-31 | 2012-07-31 | |
| US61/677,538 | 2012-07-31 | ||
| JP2019130027A JP6942757B2 (ja) | 2012-02-01 | 2019-07-12 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019130027A Division JP6942757B2 (ja) | 2012-02-01 | 2019-07-12 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022191963A Division JP7525579B2 (ja) | 2012-02-01 | 2022-11-30 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021137030A JP2021137030A (ja) | 2021-09-16 |
| JP2021137030A5 true JP2021137030A5 (enExample) | 2021-11-04 |
| JP7187615B2 JP7187615B2 (ja) | 2022-12-12 |
Family
ID=47714588
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555736A Withdrawn JP2015505477A (ja) | 2012-02-01 | 2013-02-01 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2018022012A Active JP6698718B2 (ja) | 2012-02-01 | 2018-02-09 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2019130027A Active JP6942757B2 (ja) | 2012-02-01 | 2019-07-12 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2021099420A Active JP7187615B2 (ja) | 2012-02-01 | 2021-06-15 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2022191963A Active JP7525579B2 (ja) | 2012-02-01 | 2022-11-30 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2023173593A Pending JP2023168590A (ja) | 2012-02-01 | 2023-10-05 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555736A Withdrawn JP2015505477A (ja) | 2012-02-01 | 2013-02-01 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2018022012A Active JP6698718B2 (ja) | 2012-02-01 | 2018-02-09 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2019130027A Active JP6942757B2 (ja) | 2012-02-01 | 2019-07-12 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022191963A Active JP7525579B2 (ja) | 2012-02-01 | 2022-11-30 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
| JP2023173593A Pending JP2023168590A (ja) | 2012-02-01 | 2023-10-05 | Ｖｌドメインを含む重鎖を発現するヒト化齧歯動物 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20130212719A1 (enExample) |
| EP (3) | EP3597038B1 (enExample) |
| JP (6) | JP2015505477A (enExample) |
| KR (2) | KR20140123983A (enExample) |
| CN (2) | CN106117364B (enExample) |
| AU (3) | AU2013204758B2 (enExample) |
| BR (1) | BR112014018843B1 (enExample) |
| CA (1) | CA2863175A1 (enExample) |
| CY (2) | CY1122419T1 (enExample) |
| DK (2) | DK3597038T3 (enExample) |
| ES (2) | ES2870703T3 (enExample) |
| HR (2) | HRP20192218T1 (enExample) |
| HU (2) | HUE055610T2 (enExample) |
| IL (3) | IL233827A0 (enExample) |
| LT (2) | LT2809150T (enExample) |
| ME (1) | ME03611B (enExample) |
| MX (2) | MX373286B (enExample) |
| NZ (5) | NZ719228A (enExample) |
| PL (2) | PL3597038T3 (enExample) |
| PT (2) | PT3597038T (enExample) |
| RS (2) | RS59699B1 (enExample) |
| RU (2) | RU2770016C2 (enExample) |
| SG (3) | SG10201913428QA (enExample) |
| SI (2) | SI2809150T1 (enExample) |
| SM (2) | SMT202100401T1 (enExample) |
| WO (1) | WO2013116609A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2669298A3 (en) * | 2008-05-23 | 2014-02-26 | Ablexis, LLC | Single variable immunoglobulin domain comprising VL-DH-JL |
| CN102638971B (zh) | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| EP3960865A1 (en) | 2010-08-02 | 2022-03-02 | Regeneron Pharmaceuticals, Inc. | Mice that make binding proteins comprising vl domains |
| HRP20192255T1 (hr) | 2011-08-05 | 2020-03-06 | Regeneron Pharmaceuticals, Inc. | Humanizirani miševi s univerzalnim lakim lancem |
| BR112014006390A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | anticorpos, domínios variáveis e cadeias feitos especialmente para uso humano |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| ME03477B (me) | 2011-12-20 | 2020-01-20 | Regeneron Pharma | Miševi sa humanizovanim lakim lancem |
| SG10201913428QA (en) * | 2012-02-01 | 2020-03-30 | Regeneron Pharma | Humanized rodents that express heavy chains containing vl domains |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| KR102484480B1 (ko) | 2012-06-12 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 제한된 면역글로불린 중쇄 유전자좌를 가지는 인간화된 비-인간 동물 |
| LT2840892T (lt) | 2013-02-20 | 2018-07-25 | Regeneron Pharmaceuticals, Inc. | Nežmogaus tipo gyvūnai su modifikuotomis imunoglobulino sunkiųjų grandinių sekomis |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| ES2993142T3 (en) | 2013-10-01 | 2024-12-23 | Kymab Ltd | Animal models and therapeutic molecules |
| SG10201808225TA (en) | 2014-03-21 | 2018-10-30 | Regeneron Pharma | Non-human animals that make single domain binding proteins |
| BR112016021679A2 (pt) | 2014-03-21 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | proteína de ligação ao antígeno, métodos de produção de uma proteína de ligação ao antígeno e de identificação de uma ou mais proteínas de ligação ao antígeno, hibridoma, ácido nucleico, célula, e, animal não humano geneticamente modificado. |
| HK1250038A1 (zh) * | 2015-03-19 | 2018-11-23 | 瑞泽恩制药公司 | 选择结合抗原的轻链可变区的非人动物 |
| ES2959608T3 (es) * | 2015-04-03 | 2024-02-27 | Dana Farber Cancer Inst Inc | Composición y métodos de edición del genoma de células B |
| US11802281B2 (en) * | 2016-04-04 | 2023-10-31 | Eth Zurich | Mammalian cell line for protein production and library generation |
| CN109475109B (zh) | 2016-05-20 | 2021-10-29 | 瑞泽恩制药公司 | 用于使用多个引导rna来破坏免疫耐受性的方法 |
| WO2018183946A1 (en) * | 2017-03-30 | 2018-10-04 | Utah State University | Transgenic silkworms expressing spider silk |
| LT3720279T (lt) * | 2017-12-05 | 2022-10-25 | Regeneron Pharmaceuticals, Inc. | Pelės, turinčios sukonstruotą imunoglobulino lambda lengvąją grandinę, ir jų panaudojimas |
| HUE070158T2 (hu) * | 2018-03-24 | 2025-05-28 | Regeneron Pharma | Genetikailag módosított egerek vagy patkányok peptid-mhc komplexek elleni terápiás antitestek létrehozásra, ezek elõállítására szolgáló módszerek, valamint alkalmazásuk |
| IL318469A (en) * | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| EP4211155A1 (en) | 2020-09-11 | 2023-07-19 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| CA3199879A1 (en) | 2020-12-16 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| CN114645042A (zh) * | 2020-12-18 | 2022-06-21 | 中国食品药品检定研究院 | 一种构建具有表达荧光素酶和红色荧光蛋白的重组巨噬细胞的转基因小鼠的方法 |
| CN114196626A (zh) * | 2022-02-16 | 2022-03-18 | 北京国卫生物科技有限公司 | 脐带间充质干细胞及其分离培养扩增方法 |
| EP4606901A1 (en) * | 2024-01-02 | 2025-08-27 | Gempharmatech Co., Ltd | Animal model for producing humanized antibody, and construction method therefor |
| CN121065267A (zh) * | 2024-06-04 | 2025-12-05 | 赛业（苏州）生物科技有限公司 | 用于制备四元固定轻链的基因修饰的啮齿动物及其制备方法 |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| WO2026035843A2 (en) | 2024-08-06 | 2026-02-12 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| WO2002012437A2 (en) * | 2000-08-03 | 2002-02-14 | Schooten Wim Van | Production of humanized antibodies in transgenic animals |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| CN101016543A (zh) * | 2000-11-17 | 2007-08-15 | 罗切斯特大学 | 筛选编码抗原特异性免疫球蛋白分子或其抗原特异性片段的多核苷酸的方法 |
| US7473557B2 (en) | 2001-06-06 | 2009-01-06 | Regeneron Pharmaceuticals, Inc. | Method for targeting transcriptionally active loci |
| WO2003054170A1 (en) * | 2001-12-21 | 2003-07-03 | Thromb-X Nv | Compositions for the in vitro derivation and culture of embryonic stem (es) cell lines with germline transmission capability and for the culture of adult stem cells |
| US20050246782A1 (en) * | 2002-03-22 | 2005-11-03 | Origen Therapeutics | Transgenic aves producing human polyclonal antibodies |
| CN1852925A (zh) * | 2003-07-15 | 2006-10-25 | 人类多克隆治疗公司 | 人源化免疫球蛋白基因座 |
| AU2005295269B2 (en) | 2004-10-19 | 2010-05-13 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
| CA2584814A1 (en) * | 2004-10-22 | 2006-05-04 | Therapeutic Human Polyclonals, Inc. | Suppression of endogenous immunoglobulin expression in non-human transgenic animals |
| AU2007235496B2 (en) * | 2006-03-31 | 2013-11-21 | E. R. Squibb & Sons, L.L.C. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
| SG174053A1 (en) * | 2006-09-01 | 2011-09-29 | Therapeutic Human Polyclonals Inc | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| BRPI0815848A2 (pt) * | 2007-08-30 | 2017-06-06 | The Burnet Inst | composto, linhagem de célula que produz anticorpo estável, composição, métodos para modular uma resposta imune em um indivíduo e para tratar e/ou prevenir uma doença, usos de um composto e/ou uma composição e de células dendríticas ou precursores das mesmas, métodos para enriquecer e detectar células dendríticas ou um subconjunto ou precursores das mesmas, polipeptídeo, polinucleotídeo vetor, célula hospedeira, planta transgênica, animal não humano transgênico, extrato, processo para preparar um composto ou um polipeptídeo, população enriquecida de células dendríticas e/ou precursores das mesmas, população de célula dendrítica expandida e/ou precursores das mesmas, métodos para identificar uma molécula que se liga a um polipeptídeo e para triar quanto a um composto que se liga a um polipeptídeo, uso de um polipeptídeo, um polinucleotídeo, um vetor, uma célula hospedeira, uma planta transgênica, um extrato, uma população de célula e/ou uma composição, método para produzir um composto, e, kit. |
| DK3059246T3 (en) * | 2007-09-26 | 2018-10-01 | Chugai Pharmaceutical Co Ltd | Modified constant region of an antibody |
| US7659842B2 (en) | 2007-10-24 | 2010-02-09 | Infineon Technologies Ag | Quantization error reduction in PWM full-MASH converters |
| EP2669298A3 (en) * | 2008-05-23 | 2014-02-26 | Ablexis, LLC | Single variable immunoglobulin domain comprising VL-DH-JL |
| PT3456190T (pt) * | 2008-06-27 | 2022-02-15 | Merus Nv | Animal murino transgénico produtor de anticorpo |
| WO2010022738A1 (en) * | 2008-08-29 | 2010-03-04 | Symphogen A/S | Method for cloning avian-derived antibodies |
| US9085795B2 (en) * | 2009-02-04 | 2015-07-21 | Molecular Innovations, Inc. | Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin and antibodies |
| CN102638971B (zh) * | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| AU2011266843C9 (en) * | 2010-06-17 | 2018-03-01 | Kymab Limited | Animal models and therapeutic molecules |
| EP3960865A1 (en) * | 2010-08-02 | 2022-03-02 | Regeneron Pharmaceuticals, Inc. | Mice that make binding proteins comprising vl domains |
| ME03732B (me) * | 2011-02-25 | 2021-01-20 | Regeneron Pharma | Miševi s ADAM6 |
| HRP20192255T1 (hr) * | 2011-08-05 | 2020-03-06 | Regeneron Pharmaceuticals, Inc. | Humanizirani miševi s univerzalnim lakim lancem |
| ME03477B (me) * | 2011-12-20 | 2020-01-20 | Regeneron Pharma | Miševi sa humanizovanim lakim lancem |
| SG10201913428QA (en) * | 2012-02-01 | 2020-03-30 | Regeneron Pharma | Humanized rodents that express heavy chains containing vl domains |
| KR102484480B1 (ko) * | 2012-06-12 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 제한된 면역글로불린 중쇄 유전자좌를 가지는 인간화된 비-인간 동물 |
| EP3766343B1 (en) * | 2016-11-04 | 2022-05-11 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered immunoglobulin lambda light chain locus |
-
2013
- 2013-02-01 SG SG10201913428QA patent/SG10201913428QA/en unknown
- 2013-02-01 NZ NZ719228A patent/NZ719228A/en unknown
- 2013-02-01 US US13/756,889 patent/US20130212719A1/en not_active Abandoned
- 2013-02-01 EP EP19191081.9A patent/EP3597038B1/en active Active
- 2013-02-01 HR HRP20192218TT patent/HRP20192218T1/hr unknown
- 2013-02-01 HU HUE19191081A patent/HUE055610T2/hu unknown
- 2013-02-01 RU RU2018122695A patent/RU2770016C2/ru active
- 2013-02-01 LT LT13704329T patent/LT2809150T/lt unknown
- 2013-02-01 DK DK19191081.9T patent/DK3597038T3/da active
- 2013-02-01 WO PCT/US2013/024295 patent/WO2013116609A1/en not_active Ceased
- 2013-02-01 NZ NZ810648A patent/NZ810648A/en unknown
- 2013-02-01 SI SI201331592T patent/SI2809150T1/sl unknown
- 2013-02-01 SM SM20210401T patent/SMT202100401T1/it unknown
- 2013-02-01 KR KR1020147024417A patent/KR20140123983A/ko not_active Ceased
- 2013-02-01 ES ES19191081T patent/ES2870703T3/es active Active
- 2013-02-01 PT PT191910819T patent/PT3597038T/pt unknown
- 2013-02-01 NZ NZ734504A patent/NZ734504A/en unknown
- 2013-02-01 MX MX2019002517A patent/MX373286B/es active IP Right Grant
- 2013-02-01 PL PL19191081T patent/PL3597038T3/pl unknown
- 2013-02-01 LT LTEP19191081.9T patent/LT3597038T/lt unknown
- 2013-02-01 MX MX2020003491A patent/MX2020003491A/es unknown
- 2013-02-01 RS RS20191615A patent/RS59699B1/sr unknown
- 2013-02-01 SG SG10201606256TA patent/SG10201606256TA/en unknown
- 2013-02-01 SI SI201331882T patent/SI3597038T1/sl unknown
- 2013-02-01 PT PT137043295T patent/PT2809150T/pt unknown
- 2013-02-01 ES ES13704329T patent/ES2753774T3/es active Active
- 2013-02-01 AU AU2013204758A patent/AU2013204758B2/en active Active
- 2013-02-01 EP EP21167681.2A patent/EP3912465A1/en active Pending
- 2013-02-01 EP EP13704329.5A patent/EP2809150B1/en active Active
- 2013-02-01 CA CA2863175A patent/CA2863175A1/en active Pending
- 2013-02-01 SM SM20190685T patent/SMT201900685T1/it unknown
- 2013-02-01 SG SG11201404477YA patent/SG11201404477YA/en unknown
- 2013-02-01 DK DK13704329T patent/DK2809150T3/da active
- 2013-02-01 CN CN201610371631.3A patent/CN106117364B/zh active Active
- 2013-02-01 KR KR1020187037872A patent/KR20190006029A/ko not_active Ceased
- 2013-02-01 BR BR112014018843-2A patent/BR112014018843B1/pt active IP Right Grant
- 2013-02-01 RS RS20210791A patent/RS62023B1/sr unknown
- 2013-02-01 PL PL13704329T patent/PL2809150T3/pl unknown
- 2013-02-01 HU HUE13704329A patent/HUE046744T2/hu unknown
- 2013-02-01 CN CN201380017544.2A patent/CN104202971B/zh active Active
- 2013-02-01 NZ NZ627977A patent/NZ627977A/en active IP Right Revival
- 2013-02-01 ME MEP-2019-348A patent/ME03611B/me unknown
- 2013-02-01 JP JP2014555736A patent/JP2015505477A/ja not_active Withdrawn
- 2013-02-01 RU RU2014133653A patent/RU2664185C2/ru active
- 2013-02-01 NZ NZ793447A patent/NZ793447A/en unknown
-
2014
- 2014-07-27 IL IL233827A patent/IL233827A0/en active IP Right Grant
-
2015
- 2015-10-23 AU AU2015246154A patent/AU2015246154B2/en active Active
-
2016
- 2016-10-14 US US15/294,488 patent/US20170094955A1/en not_active Abandoned
-
2017
- 2017-10-27 AU AU2017251848A patent/AU2017251848B2/en active Active
-
2018
- 2018-02-09 JP JP2018022012A patent/JP6698718B2/ja active Active
- 2018-08-21 IL IL261280A patent/IL261280B/en active IP Right Grant
-
2019
- 2019-07-12 JP JP2019130027A patent/JP6942757B2/ja active Active
- 2019-08-13 IL IL268675A patent/IL268675B/en active IP Right Grant
- 2019-12-10 CY CY20191101302T patent/CY1122419T1/el unknown
-
2021
- 2021-04-07 US US17/224,524 patent/US20210368751A1/en not_active Abandoned
- 2021-06-15 JP JP2021099420A patent/JP7187615B2/ja active Active
- 2021-06-23 HR HRP20210987TT patent/HRP20210987T1/hr unknown
- 2021-07-20 CY CY20211100659T patent/CY1124361T1/el unknown
-
2022
- 2022-11-30 JP JP2022191963A patent/JP7525579B2/ja active Active
-
2023
- 2023-10-05 JP JP2023173593A patent/JP2023168590A/ja active Pending