JP2020501516A5 - - Google Patents
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- Publication number
- JP2020501516A5 JP2020501516A5 JP2019522647A JP2019522647A JP2020501516A5 JP 2020501516 A5 JP2020501516 A5 JP 2020501516A5 JP 2019522647 A JP2019522647 A JP 2019522647A JP 2019522647 A JP2019522647 A JP 2019522647A JP 2020501516 A5 JP2020501516 A5 JP 2020501516A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- mouse
- gene segments
- light chain
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 111
- 108060003951 Immunoglobulin Proteins 0.000 claims description 54
- 102000018358 immunoglobulin Human genes 0.000 claims description 54
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 23
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 23
- 238000003780 insertion Methods 0.000 claims description 22
- 230000037431 insertion Effects 0.000 claims description 22
- 239000003623 enhancer Substances 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 18
- 210000004602 germ cell Anatomy 0.000 claims description 14
- 108091092724 Noncoding DNA Proteins 0.000 claims description 10
- 102100029567 Immunoglobulin kappa light chain Human genes 0.000 claims description 9
- 101710189008 Immunoglobulin kappa light chain Proteins 0.000 claims description 9
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 7
- 239000002773 nucleotide Substances 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims description 4
- 108020004414 DNA Proteins 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 238000012217 deletion Methods 0.000 claims description 2
- 230000037430 deletion Effects 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 48
- 241000699670 Mus sp. Species 0.000 claims 6
- 241001529936 Murinae Species 0.000 claims 2
- 108700031127 mouse Adam6a Proteins 0.000 claims 2
- 210000002308 embryonic cell Anatomy 0.000 claims 1
- 241000283984 Rodentia Species 0.000 description 81
- 210000004027 cell Anatomy 0.000 description 5
- 239000000427 antigen Substances 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- 230000028993 immune response Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662417845P | 2016-11-04 | 2016-11-04 | |
| US62/417,845 | 2016-11-04 | ||
| US201762567932P | 2017-10-04 | 2017-10-04 | |
| US62/567,932 | 2017-10-04 | ||
| PCT/US2017/060006 WO2018128691A1 (en) | 2016-11-04 | 2017-11-03 | Non-human animals having an engineered immunoglobulin lambda light chain locus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021036180A Division JP2021090455A (ja) | 2016-11-04 | 2021-03-08 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020501516A JP2020501516A (ja) | 2020-01-23 |
| JP2020501516A5 true JP2020501516A5 (enExample) | 2020-12-10 |
| JP6884860B2 JP6884860B2 (ja) | 2021-06-09 |
Family
ID=62025924
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522647A Active JP6884860B2 (ja) | 2016-11-04 | 2017-11-03 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2021036180A Withdrawn JP2021090455A (ja) | 2016-11-04 | 2021-03-08 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2022109658A Active JP7386292B2 (ja) | 2016-11-04 | 2022-07-07 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2023023312A Withdrawn JP2023053400A (ja) | 2016-11-04 | 2023-02-17 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2025135726A Pending JP2025166207A (ja) | 2016-11-04 | 2025-08-18 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021036180A Withdrawn JP2021090455A (ja) | 2016-11-04 | 2021-03-08 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2022109658A Active JP7386292B2 (ja) | 2016-11-04 | 2022-07-07 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2023023312A Withdrawn JP2023053400A (ja) | 2016-11-04 | 2023-02-17 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2025135726A Pending JP2025166207A (ja) | 2016-11-04 | 2025-08-18 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US10820582B2 (enExample) |
| EP (4) | EP3766343B1 (enExample) |
| JP (5) | JP6884860B2 (enExample) |
| KR (4) | KR102658529B1 (enExample) |
| CN (2) | CN109996441B (enExample) |
| AU (2) | AU2017391167B2 (enExample) |
| BR (1) | BR112019008675A2 (enExample) |
| CA (1) | CA3038720A1 (enExample) |
| CY (2) | CY1123491T1 (enExample) |
| DK (3) | DK4082334T3 (enExample) |
| ES (3) | ES2823305T3 (enExample) |
| FI (1) | FI4082334T3 (enExample) |
| HR (3) | HRP20201403T1 (enExample) |
| HU (3) | HUE052087T2 (enExample) |
| IL (2) | IL308197A (enExample) |
| LT (3) | LT3766343T (enExample) |
| MA (2) | MA53935A (enExample) |
| MX (2) | MX385857B (enExample) |
| PL (3) | PL3766343T3 (enExample) |
| PT (3) | PT4082334T (enExample) |
| RS (3) | RS66884B1 (enExample) |
| RU (2) | RU2021129958A (enExample) |
| SG (2) | SG11201903344XA (enExample) |
| SI (3) | SI3766343T1 (enExample) |
| SM (3) | SMT202200259T1 (enExample) |
| WO (1) | WO2018128691A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2580017C2 (ru) | 2010-07-26 | 2016-04-10 | Трианни, Инк. | Трансгенные животные и способы применения |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| PL2809150T3 (pl) * | 2012-02-01 | 2020-04-30 | Regeneron Pharmaceuticals, Inc. | Humanizowane myszy wykazujące ekspresję łańcuchów ciężkich zawierających domeny VL |
| WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
| MA53935A (fr) | 2016-11-04 | 2021-12-22 | Regeneron Pharma | Animaux non humains ayant un locus à chaîne légère lambda d'immunoglobuline modifiée |
| SMT202500038T1 (it) | 2018-03-24 | 2025-03-12 | Regeneron Pharma | Topi o ratti geneticamente modificati per la generazione di anticorpi terapeutici contro complessi peptide-mhc, metodi di produzione e loro utilizzo |
| KR20250121150A (ko) | 2018-03-26 | 2025-08-11 | 리제너론 파마슈티칼스 인코포레이티드 | 치료제를 시험하기 위한 인간화된 설치류 |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| EP3927153A1 (en) | 2019-02-22 | 2021-12-29 | Regeneron Pharmaceuticals, Inc. | Rodents having genetically modified sodium channels and methods of use thereof |
| JP7752536B2 (ja) * | 2019-07-01 | 2025-10-10 | トリアニ・インコーポレイテッド | トランスジェニック哺乳動物およびその使用法 |
| AU2021283564B2 (en) * | 2020-06-02 | 2025-05-29 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with common light chain immunoglobulin locus |
| EP4211155A1 (en) | 2020-09-11 | 2023-07-19 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| EP4262373A1 (en) | 2020-12-16 | 2023-10-25 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| JP7758739B2 (ja) | 2020-12-23 | 2025-10-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | アンカー改変型抗体をコードする核酸およびその使用 |
| AU2021409906A1 (en) | 2020-12-23 | 2023-06-15 | Regeneron Pharmaceuticals, Inc. | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same |
| GB202217978D0 (en) * | 2022-11-30 | 2023-01-11 | Petmedix Ltd | Rodents expressing a common light chain |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2124967C (en) * | 1991-12-17 | 2008-04-08 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7435871B2 (en) | 2001-11-30 | 2008-10-14 | Amgen Fremont Inc. | Transgenic animals bearing human Igλ light chain genes |
| MXPA06000562A (es) * | 2003-07-15 | 2006-03-30 | Therapeutic Human Polyclonals | Loci de inmunoglobulina humanizada. |
| CA2652976C (en) | 2006-06-02 | 2015-08-11 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human il-6 receptor |
| LT2346994T (lt) | 2008-09-30 | 2022-03-10 | Ablexis, Llc | Knock-in pelė, skirta chimerinių antikūnų gamybai |
| CN112690250B (zh) * | 2008-12-18 | 2024-03-08 | 伊拉兹马斯大学鹿特丹医学中心 | 表达人源化抗体的非人转基因动物及其用途 |
| EP3028565B1 (en) * | 2009-07-08 | 2017-09-27 | Kymab Limited | Animal models and therapeutic molecules |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| WO2011115476A1 (en) | 2010-03-17 | 2011-09-22 | N.V. Nutricia | Infant nutrition for improving fatty acid composition of brain membranes later in life |
| SI2480676T1 (sl) | 2010-06-22 | 2016-10-28 | Regeneron Pharmaceuticals, Inc. | Hibridna mišja lahka veriga |
| DK2813573T1 (da) | 2011-02-25 | 2015-01-12 | Regeneron Pharma | ADAM6 mus |
| PL3216871T3 (pl) | 2011-10-17 | 2022-03-21 | Regeneron Pharmaceuticals, Inc. | Ograniczony łańcuch ciężki immonoglobuliny pochodzącej od myszy |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| MX378871B (es) * | 2011-12-20 | 2025-03-10 | Regeneron Pharma | Ratones con cadena ligera humanizada. |
| RS57582B1 (sr) * | 2013-02-20 | 2018-11-30 | Regeneron Pharma | Nehumane životinje sa modifikovanim sekvencama imunoglobulinskog teškog lanca |
| JP6475172B2 (ja) | 2013-02-20 | 2019-02-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ラットの遺伝子組換え |
| US9788534B2 (en) * | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| WO2015049517A2 (en) * | 2013-10-01 | 2015-04-09 | Kymab Limited | Animal models and therapeutic molecules |
| MX388127B (es) | 2013-12-11 | 2025-03-19 | Regeneron Pharma | Metodos y composiciones para la modificacion dirigida de un genoma. |
| BR112016028564A2 (pt) | 2014-06-06 | 2018-01-30 | Regeneron Pharma | método para modificar um locus-alvo em uma célula. |
| MX384887B (es) | 2014-06-23 | 2025-03-14 | Regeneron Pharma | Ensamblaje de adn mediado por nucleasa. |
| CA3176380A1 (en) | 2014-11-21 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide rnas |
| BR112017013104A2 (pt) | 2014-12-19 | 2018-05-15 | Regeneron Pharma | métodos para modificar um locus genômico alvo em uma célula, para intensificar a recombinação homóloga em um locus genômico alvo em uma célula e para produzir uma geração f0 de um animal não humano. |
| MA53935A (fr) | 2016-11-04 | 2021-12-22 | Regeneron Pharma | Animaux non humains ayant un locus à chaîne légère lambda d'immunoglobuline modifiée |
-
2017
- 2017-11-03 MA MA053935A patent/MA53935A/fr unknown
- 2017-11-03 PL PL20180508.2T patent/PL3766343T3/pl unknown
- 2017-11-03 WO PCT/US2017/060006 patent/WO2018128691A1/en not_active Ceased
- 2017-11-03 PT PT221647514T patent/PT4082334T/pt unknown
- 2017-11-03 BR BR112019008675A patent/BR112019008675A2/pt unknown
- 2017-11-03 MA MA044091A patent/MA44091A/fr unknown
- 2017-11-03 SI SI201731147T patent/SI3766343T1/sl unknown
- 2017-11-03 SM SM20220259T patent/SMT202200259T1/it unknown
- 2017-11-03 LT LTEP20180508.2T patent/LT3766343T/lt unknown
- 2017-11-03 ES ES17863293T patent/ES2823305T3/es active Active
- 2017-11-03 DK DK22164751.4T patent/DK4082334T3/da active
- 2017-11-03 EP EP20180508.2A patent/EP3766343B1/en active Active
- 2017-11-03 EP EP25157740.9A patent/EP4567119A3/en active Pending
- 2017-11-03 CN CN201780067880.6A patent/CN109996441B/zh active Active
- 2017-11-03 ES ES22164751T patent/ES3035365T3/es active Active
- 2017-11-03 RS RS20250535A patent/RS66884B1/sr unknown
- 2017-11-03 IL IL308197A patent/IL308197A/en unknown
- 2017-11-03 PT PT178632931T patent/PT3407709T/pt unknown
- 2017-11-03 HU HUE17863293A patent/HUE052087T2/hu unknown
- 2017-11-03 EP EP17863293.1A patent/EP3407709B9/en active Active
- 2017-11-03 RU RU2021129958A patent/RU2021129958A/ru unknown
- 2017-11-03 DK DK17863293.1T patent/DK3407709T3/da active
- 2017-11-03 HR HRP20201403TT patent/HRP20201403T1/hr unknown
- 2017-11-03 RS RS20220669A patent/RS63390B1/sr unknown
- 2017-11-03 RS RS20201205A patent/RS60886B1/sr unknown
- 2017-11-03 KR KR1020237002504A patent/KR102658529B1/ko active Active
- 2017-11-03 HR HRP20250695TT patent/HRP20250695T1/hr unknown
- 2017-11-03 PL PL17863293T patent/PL3407709T3/pl unknown
- 2017-11-03 KR KR1020247012338A patent/KR20240055863A/ko active Pending
- 2017-11-03 JP JP2019522647A patent/JP6884860B2/ja active Active
- 2017-11-03 SG SG11201903344XA patent/SG11201903344XA/en unknown
- 2017-11-03 ES ES20180508T patent/ES2915609T3/es active Active
- 2017-11-03 HU HUE22164751A patent/HUE071595T2/hu unknown
- 2017-11-03 HU HUE20180508A patent/HUE061980T2/hu unknown
- 2017-11-03 SG SG10201913483XA patent/SG10201913483XA/en unknown
- 2017-11-03 LT LTEP17863293.1T patent/LT3407709T/lt unknown
- 2017-11-03 HR HRP20220888TT patent/HRP20220888T1/hr unknown
- 2017-11-03 DK DK20180508.2T patent/DK3766343T3/da active
- 2017-11-03 LT LTEP22164751.4T patent/LT4082334T/lt unknown
- 2017-11-03 SM SM20200558T patent/SMT202000558T1/it unknown
- 2017-11-03 RU RU2019112589A patent/RU2757665C2/ru active
- 2017-11-03 FI FIEP22164751.4T patent/FI4082334T3/fi active
- 2017-11-03 MX MX2019005256A patent/MX385857B/es unknown
- 2017-11-03 EP EP22164751.4A patent/EP4082334B1/en active Active
- 2017-11-03 IL IL266282A patent/IL266282B2/en unknown
- 2017-11-03 SI SI201730381T patent/SI3407709T1/sl unknown
- 2017-11-03 CA CA3038720A patent/CA3038720A1/en active Pending
- 2017-11-03 SI SI201731606T patent/SI4082334T1/sl unknown
- 2017-11-03 PT PT201805082T patent/PT3766343T/pt unknown
- 2017-11-03 CN CN202210050898.8A patent/CN114369157A/zh active Pending
- 2017-11-03 SM SM20250204T patent/SMT202500204T1/it unknown
- 2017-11-03 US US15/803,513 patent/US10820582B2/en active Active
- 2017-11-03 PL PL22164751.4T patent/PL4082334T3/pl unknown
- 2017-11-03 KR KR1020217034468A patent/KR102492433B1/ko active Active
- 2017-11-03 KR KR1020197015717A patent/KR102319069B1/ko active Active
- 2017-11-03 AU AU2017391167A patent/AU2017391167B2/en active Active
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2019
- 2019-05-03 MX MX2021010556A patent/MX2021010556A/es unknown
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2020
- 2020-09-24 US US17/031,367 patent/US12433264B2/en active Active
- 2020-10-29 CY CY20201101022T patent/CY1123491T1/el unknown
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2021
- 2021-03-08 JP JP2021036180A patent/JP2021090455A/ja not_active Withdrawn
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2022
- 2022-07-07 JP JP2022109658A patent/JP7386292B2/ja active Active
- 2022-08-08 CY CY20221100540T patent/CY1125474T1/el unknown
-
2023
- 2023-02-17 JP JP2023023312A patent/JP2023053400A/ja not_active Withdrawn
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2024
- 2024-01-31 AU AU2024200582A patent/AU2024200582A1/en active Pending
-
2025
- 2025-08-18 JP JP2025135726A patent/JP2025166207A/ja active Pending
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