JP2020501516A5 - - Google Patents

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Publication number
JP2020501516A5
JP2020501516A5 JP2019522647A JP2019522647A JP2020501516A5 JP 2020501516 A5 JP2020501516 A5 JP 2020501516A5 JP 2019522647 A JP2019522647 A JP 2019522647A JP 2019522647 A JP2019522647 A JP 2019522647A JP 2020501516 A5 JP2020501516 A5 JP 2020501516A5
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JP
Japan
Prior art keywords
human
mouse
gene segments
light chain
immunoglobulin
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Application number
JP2019522647A
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English (en)
Japanese (ja)
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JP2020501516A (ja
JP6884860B2 (ja
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Priority claimed from PCT/US2017/060006 external-priority patent/WO2018128691A1/en
Publication of JP2020501516A publication Critical patent/JP2020501516A/ja
Publication of JP2020501516A5 publication Critical patent/JP2020501516A5/ja
Application granted granted Critical
Publication of JP6884860B2 publication Critical patent/JP6884860B2/ja
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JP2019522647A 2016-11-04 2017-11-03 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 Active JP6884860B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662417845P 2016-11-04 2016-11-04
US62/417,845 2016-11-04
US201762567932P 2017-10-04 2017-10-04
US62/567,932 2017-10-04
PCT/US2017/060006 WO2018128691A1 (en) 2016-11-04 2017-11-03 Non-human animals having an engineered immunoglobulin lambda light chain locus

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021036180A Division JP2021090455A (ja) 2016-11-04 2021-03-08 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物

Publications (3)

Publication Number Publication Date
JP2020501516A JP2020501516A (ja) 2020-01-23
JP2020501516A5 true JP2020501516A5 (enExample) 2020-12-10
JP6884860B2 JP6884860B2 (ja) 2021-06-09

Family

ID=62025924

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2019522647A Active JP6884860B2 (ja) 2016-11-04 2017-11-03 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2021036180A Withdrawn JP2021090455A (ja) 2016-11-04 2021-03-08 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2022109658A Active JP7386292B2 (ja) 2016-11-04 2022-07-07 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2023023312A Withdrawn JP2023053400A (ja) 2016-11-04 2023-02-17 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2025135726A Pending JP2025166207A (ja) 2016-11-04 2025-08-18 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2021036180A Withdrawn JP2021090455A (ja) 2016-11-04 2021-03-08 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2022109658A Active JP7386292B2 (ja) 2016-11-04 2022-07-07 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2023023312A Withdrawn JP2023053400A (ja) 2016-11-04 2023-02-17 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2025135726A Pending JP2025166207A (ja) 2016-11-04 2025-08-18 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物

Country Status (26)

Country Link
US (3) US10820582B2 (enExample)
EP (4) EP3766343B1 (enExample)
JP (5) JP6884860B2 (enExample)
KR (4) KR102319069B1 (enExample)
CN (2) CN114369157A (enExample)
AU (2) AU2017391167B2 (enExample)
BR (1) BR112019008675A2 (enExample)
CA (1) CA3038720A1 (enExample)
CY (2) CY1123491T1 (enExample)
DK (3) DK3766343T3 (enExample)
ES (3) ES2915609T3 (enExample)
FI (1) FI4082334T3 (enExample)
HR (3) HRP20201403T1 (enExample)
HU (3) HUE052087T2 (enExample)
IL (2) IL308197A (enExample)
LT (3) LT3407709T (enExample)
MA (2) MA44091A (enExample)
MX (2) MX385857B (enExample)
PL (3) PL3407709T3 (enExample)
PT (3) PT3407709T (enExample)
RS (3) RS60886B1 (enExample)
RU (2) RU2021129958A (enExample)
SG (2) SG10201913483XA (enExample)
SI (3) SI3766343T1 (enExample)
SM (3) SMT202000558T1 (enExample)
WO (1) WO2018128691A1 (enExample)

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EP3384030A4 (en) 2015-12-03 2019-07-03 Trianni, Inc. IMPROVED IMMUNOGLULINIVITY
EP3766343B1 (en) 2016-11-04 2022-05-11 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered immunoglobulin lambda light chain locus
HUE070158T2 (hu) 2018-03-24 2025-05-28 Regeneron Pharma Genetikailag módosított egerek vagy patkányok peptid-mhc komplexek elleni terápiás antitestek létrehozásra, ezek elõállítására szolgáló módszerek, valamint alkalmazásuk
JP7328243B2 (ja) 2018-03-26 2023-08-16 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 治療薬を試験するためのヒト化げっ歯類
IL318469A (en) 2018-06-14 2025-03-01 Regeneron Pharma Non-human animals capable of reorganizing transgenic DH-DH, and their uses
SG11202107589PA (en) 2019-02-22 2021-08-30 Regeneron Pharma Rodents having genetically modified sodium channels and methods of use thereof
ES3027509T3 (en) * 2019-07-01 2025-06-16 Zoetis Services Llc Transgenic rodents and methods of use thereof
IL298632A (en) * 2020-06-02 2023-01-01 Biocytogen Pharmaceuticals Beijing Co Ltd Non-human animals genetically modified with a common light chain immunoglobulin locus
EP4211155A1 (en) 2020-09-11 2023-07-19 Regeneron Pharmaceuticals, Inc. Identification and production of antigen-specific antibodies
CA3199879A1 (en) 2020-12-16 2022-06-23 Regeneron Pharmaceuticals, Inc. Mice expressing humanized fc alpha receptors
US20240317849A1 (en) 2020-12-23 2024-09-26 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding anchor modified antibodies and uses thereof
JP2024501796A (ja) 2020-12-23 2024-01-16 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 膜貫通タンパク質に結合する抗体、および抗体を産生する細胞を取得する方法
IL312359A (en) * 2021-11-10 2024-06-01 Trianni Inc Transgenic mammals and methods of use thereof
GB202217978D0 (en) * 2022-11-30 2023-01-11 Petmedix Ltd Rodents expressing a common light chain
WO2026030428A2 (en) 2024-08-01 2026-02-05 Regeneron Pharmaceuticals, Inc. Prostate-specific antigen peptides and uses thereof
WO2026035843A2 (en) 2024-08-06 2026-02-12 Regeneron Pharmaceuticals, Inc. Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof

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EP3766343B1 (en) 2016-11-04 2022-05-11 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered immunoglobulin lambda light chain locus

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