JP2020501516A5 - - Google Patents

Download PDF

Info

Publication number
JP2020501516A5
JP2020501516A5 JP2019522647A JP2019522647A JP2020501516A5 JP 2020501516 A5 JP2020501516 A5 JP 2020501516A5 JP 2019522647 A JP2019522647 A JP 2019522647A JP 2019522647 A JP2019522647 A JP 2019522647A JP 2020501516 A5 JP2020501516 A5 JP 2020501516A5
Authority
JP
Japan
Prior art keywords
human
mouse
gene segments
light chain
immunoglobulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019522647A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020501516A (ja
JP6884860B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/060006 external-priority patent/WO2018128691A1/en
Publication of JP2020501516A publication Critical patent/JP2020501516A/ja
Publication of JP2020501516A5 publication Critical patent/JP2020501516A5/ja
Application granted granted Critical
Publication of JP6884860B2 publication Critical patent/JP6884860B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019522647A 2016-11-04 2017-11-03 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 Active JP6884860B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662417845P 2016-11-04 2016-11-04
US62/417,845 2016-11-04
US201762567932P 2017-10-04 2017-10-04
US62/567,932 2017-10-04
PCT/US2017/060006 WO2018128691A1 (en) 2016-11-04 2017-11-03 Non-human animals having an engineered immunoglobulin lambda light chain locus

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021036180A Division JP2021090455A (ja) 2016-11-04 2021-03-08 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物

Publications (3)

Publication Number Publication Date
JP2020501516A JP2020501516A (ja) 2020-01-23
JP2020501516A5 true JP2020501516A5 (enExample) 2020-12-10
JP6884860B2 JP6884860B2 (ja) 2021-06-09

Family

ID=62025924

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2019522647A Active JP6884860B2 (ja) 2016-11-04 2017-11-03 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2021036180A Withdrawn JP2021090455A (ja) 2016-11-04 2021-03-08 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2022109658A Active JP7386292B2 (ja) 2016-11-04 2022-07-07 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2023023312A Withdrawn JP2023053400A (ja) 2016-11-04 2023-02-17 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2025135726A Pending JP2025166207A (ja) 2016-11-04 2025-08-18 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2021036180A Withdrawn JP2021090455A (ja) 2016-11-04 2021-03-08 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2022109658A Active JP7386292B2 (ja) 2016-11-04 2022-07-07 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2023023312A Withdrawn JP2023053400A (ja) 2016-11-04 2023-02-17 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物
JP2025135726A Pending JP2025166207A (ja) 2016-11-04 2025-08-18 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物

Country Status (26)

Country Link
US (3) US10820582B2 (enExample)
EP (4) EP4567119A3 (enExample)
JP (5) JP6884860B2 (enExample)
KR (4) KR102492433B1 (enExample)
CN (2) CN114369157A (enExample)
AU (3) AU2017391167B2 (enExample)
BR (1) BR112019008675A2 (enExample)
CA (1) CA3038720A1 (enExample)
CY (2) CY1123491T1 (enExample)
DK (3) DK3766343T3 (enExample)
ES (3) ES2823305T3 (enExample)
FI (1) FI4082334T3 (enExample)
HR (3) HRP20250695T1 (enExample)
HU (3) HUE071595T2 (enExample)
IL (2) IL266282B2 (enExample)
LT (3) LT3407709T (enExample)
MA (2) MA53935A (enExample)
MX (2) MX385857B (enExample)
PL (3) PL3766343T3 (enExample)
PT (3) PT4082334T (enExample)
RS (3) RS63390B1 (enExample)
RU (1) RU2757665C2 (enExample)
SG (2) SG10201913483XA (enExample)
SI (3) SI3766343T1 (enExample)
SM (3) SMT202000558T1 (enExample)
WO (1) WO2018128691A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10662256B2 (en) 2010-07-26 2020-05-26 Trianni, Inc. Transgenic mammals and methods of use thereof
CN103025884B (zh) 2010-07-26 2015-11-25 特里安尼公司 转基因动物和使用方法
RU2664185C2 (ru) * 2012-02-01 2018-08-15 Регенерон Фармасьютикалз, Инк. Гуманизированные грызуны, которые экспрессируют тяжелые цепи, содержащие домены vl
EP3384030A4 (en) 2015-12-03 2019-07-03 Trianni, Inc. IMPROVED IMMUNOGLULINIVITY
EP4567119A3 (en) 2016-11-04 2025-09-24 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered immunoglobulin lambda light chain locus
EP4534560A3 (en) 2018-03-24 2025-06-11 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof
IL277355B2 (en) 2018-03-26 2025-01-01 Regeneron Pharma Humanized rodents for testing therapeutic agents
IL318469A (en) 2018-06-14 2025-03-01 Regeneron Pharma Non-human animals capable of reorganizing transgenic DH-DH, and their uses
BR112021016173A2 (pt) 2019-02-22 2021-11-03 Regeneron Pharma Roedor geneticamente modificado, métodos de produção de um roedor geneticamente modificado e de produção de um anticorpo anti-nav1.7, célula ou tecido isolado de roedor, linhagem celular imortalizada, embrião de roedor, construto de ácido nucleico de direcionamento, e, hibridoma
KR102953869B1 (ko) * 2019-07-01 2026-04-17 조에티스 서비시즈 엘엘씨 유전자이식 포유동물 및 이의 사용 방법
CN115667532A (zh) * 2020-06-02 2023-01-31 百奥赛图(北京)医药科技股份有限公司 具有共有轻链免疫球蛋白基因座的经遗传修饰的非人动物
US20220090060A1 (en) 2020-09-11 2022-03-24 Regeneron Pharmaceuticals, Inc. Identification and production of antigen-specific antibodies
EP4262373A1 (en) 2020-12-16 2023-10-25 Regeneron Pharmaceuticals, Inc. Mice expressing humanized fc alpha receptors
CA3197426A1 (en) 2020-12-23 2022-06-30 Regeneron Pharmaceuticals, Inc. Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same
MX2023007401A (es) 2020-12-23 2023-07-06 Regeneron Pharma Acidos nucleicos que codifican anticuerpos modificados por anclaje y usos de los mismos.
JP2024543248A (ja) * 2021-11-10 2024-11-20 トリアニ・インコーポレイテッド トランスジェニック哺乳動物およびその使用方法
GB202217978D0 (en) * 2022-11-30 2023-01-11 Petmedix Ltd Rodents expressing a common light chain
WO2026030428A2 (en) 2024-08-01 2026-02-05 Regeneron Pharmaceuticals, Inc. Prostate-specific antigen peptides and uses thereof
US20260123608A1 (en) 2024-08-06 2026-05-07 Regeneron Pharmaceuticals, Inc. Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof
WO2026096736A1 (en) 2024-10-31 2026-05-07 Regeneron Pharmaceuticals, Inc. Rodents expressing humanized polymeric immunoglobulin receptor

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07503132A (ja) * 1991-12-17 1995-04-06 ジェンファーム　インターナショナル，インコーポレイティド 異種抗体を産生することができるトランスジェニック非ヒト動物
US5670356A (en) 1994-12-12 1997-09-23 Promega Corporation Modified luciferase
US5874304A (en) 1996-01-18 1999-02-23 University Of Florida Research Foundation, Inc. Humanized green fluorescent protein genes and methods
GB9823930D0 (en) 1998-11-03 1998-12-30 Babraham Inst Murine expression of human ig\ locus
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
ES2645563T3 (es) 2001-11-30 2017-12-05 Amgen Fremont Inc. Animales transgénicos que portan genes de cadena ligera de Ig humana
MXPA06000562A (es) * 2003-07-15 2006-03-30 Therapeutic Human Polyclonals Loci de inmunoglobulina humanizada.
ATE537190T1 (de) 2006-06-02 2011-12-15 Regeneron Pharma Hochaffine antikörper gegen den humanen il-6- rezeptor
PL2346994T3 (pl) 2008-09-30 2022-04-19 Ablexis, Llc Myszy knock-in do wytwarzania chimerycznych przeciwciał
KR101711222B1 (ko) * 2008-12-18 2017-02-28 에라스무스 유니버시티 메디컬 센터 로테르담 인간화 항체들을 발현하는 비-인간 유전자이식 동물들 및 그의 이용
DK3241435T3 (da) * 2009-07-08 2021-08-23 Kymab Ltd Dyremodeller og terapeutiske molekyler
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
WO2011115476A1 (en) 2010-03-17 2011-09-22 N.V. Nutricia Infant nutrition for improving fatty acid composition of brain membranes later in life
MY195217A (en) 2010-06-22 2023-01-11 Regeneron Pharma MICE Expressing An Immunoglobulin Hybrid Light Chain
CN105861548B (zh) 2011-02-25 2020-01-10 瑞泽恩制药公司 Adam6小鼠
EP4074833A1 (en) 2011-10-17 2022-10-19 Regeneron Pharmaceuticals, Inc. Restricted immunoglobulin heavy chain mice
US9253965B2 (en) * 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
SMT201900296T1 (it) * 2011-12-20 2019-07-11 Regeneron Pharma Topi di catena leggera umanizzata
RS57582B1 (sr) * 2013-02-20 2018-11-30 Regeneron Pharma Nehumane životinje sa modifikovanim sekvencama imunoglobulinskog teškog lanca
MX2015010841A (es) 2013-02-20 2016-05-09 Regeneron Pharma Modificacion genetica de ratas.
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
WO2015049517A2 (en) * 2013-10-01 2015-04-09 Kymab Limited Animal models and therapeutic molecules
MX388127B (es) 2013-12-11 2025-03-19 Regeneron Pharma Metodos y composiciones para la modificacion dirigida de un genoma.
DK3152312T3 (da) 2014-06-06 2020-04-06 Regeneron Pharma Fremgangsmåder og sammensætninger til modifikation af et mållocus
US9738897B2 (en) 2014-06-23 2017-08-22 Regeneron Pharmaceuticals, Inc. Nuclease-mediated DNA assembly
EP3221457B1 (en) 2014-11-21 2019-03-20 Regeneron Pharmaceuticals, Inc. Methods and compositions for targeted genetic modification using paired guide rnas
MX388784B (es) 2014-12-19 2025-03-20 Regeneron Pharma Métodos y composiciones para la modificación genética dirigida a través de direccionamiento múltiple de una sola etapa.
EP4567119A3 (en) 2016-11-04 2025-09-24 Regeneron Pharmaceuticals, Inc. Non-human animals having an engineered immunoglobulin lambda light chain locus

Similar Documents

Publication Publication Date Title
JP2015505477A5 (enExample)
RU2019112589A (ru) Отличные от человека животные со сконструированным локусом легкой лямбда-цепи иммуноглобулина
JP2018138047A5 (enExample)
RU2014133653A (ru) Гуманизированные грызуны, которые экспрессируют тяжелые цепи, содержащие домены vl
EP3341485B1 (en) Enhanced production of immunoglobulins
JP2015519076A5 (enExample)
DK2825036T3 (en) Histidine engineered light chain antibodies and genetically modified rodents to generate them
ES2575223T3 (es) Ratones que expresan una cadena ligera con las regiones variable lambda humana y constante de ratón
JP2015502177A5 (enExample)
JP2017509355A5 (enExample)
RU2014127339A (ru) Мыши с гуманизированной легкой цепью
JP2013535213A5 (enExample)
JP2015510767A5 (enExample)
RU2019121863A (ru) Антитела со встроенным в легкие цепи гистидином и генетически модифицированные отличные от человека животные для их получения
JP2014524243A5 (enExample)
CN109072191A (zh) 用于蛋白生产和文库产生的哺乳动物细胞系
HRP20170322T1 (hr) Miševi koji stvaraju vl vezne proteine
JP2016512034A5 (enExample)
RU2014153673A (ru) Гуманизированные не относящиеся к человеку животные с ограниченными локусами тяжелой цепи иммуноглобулина
RU2016141307A (ru) Отличные от человека животные, которые вырабатывают однодоменные связывающие белки
JP2013532974A5 (enExample)
JP2014110814A5 (enExample)
CN107090471A (zh) 共同轻链小鼠
SI2840892T1 (en) Animals other than humans with modified immunoglobulin heavy chain sequences
HUE029785T2 (en) Common light chain mouse