BR112019008675A2 - roedor, célula isolada de roedor, e, métodos de produção de um roedor e de um anticorpo em um roedor. - Google Patents
roedor, célula isolada de roedor, e, métodos de produção de um roedor e de um anticorpo em um roedor.Info
- Publication number
- BR112019008675A2 BR112019008675A2 BR112019008675A BR112019008675A BR112019008675A2 BR 112019008675 A2 BR112019008675 A2 BR 112019008675A2 BR 112019008675 A BR112019008675 A BR 112019008675A BR 112019008675 A BR112019008675 A BR 112019008675A BR 112019008675 A2 BR112019008675 A2 BR 112019008675A2
- Authority
- BR
- Brazil
- Prior art keywords
- rodent
- human
- methods
- human animals
- lambda light
- Prior art date
Links
- 241000283984 Rodentia Species 0.000 title 4
- 210000005260 human cell Anatomy 0.000 abstract 2
- 108700005091 Immunoglobulin Genes Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
são fornecidos animais não humanos (e/ou células não humanas) e métodos de uso e produção dos mesmos, em que os animais não humanos (e/ou células não humanas) têm um genoma que compreende sequências codificantes de anticorpo humano (isto é, genes de imunoglobulina). os animais não humanos descritos neste documento expressam anticorpos que contêm cadeias leves de ig lambda humana, no todo ou em parte. em particular, os animais não humanos fornecidos neste documento são, em algumas modalidades, caracterizados pela expressão de anticorpos que contêm cadeias leves de ig lambda humana, no todo ou em parte, que são codificadas pelas sequências codificantes de cadeia leve de ig lambda humanas inseridas em um locus de cadeia leve de ig lambda endógena dos referidos animais não humanos. também são fornecidos métodos para produzir anticorpos a partir dos animais não humanos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662417845P | 2016-11-04 | 2016-11-04 | |
| US201762567932P | 2017-10-04 | 2017-10-04 | |
| PCT/US2017/060006 WO2018128691A1 (en) | 2016-11-04 | 2017-11-03 | Non-human animals having an engineered immunoglobulin lambda light chain locus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019008675A2 true BR112019008675A2 (pt) | 2019-07-09 |
Family
ID=62025924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019008675A BR112019008675A2 (pt) | 2016-11-04 | 2017-11-03 | roedor, célula isolada de roedor, e, métodos de produção de um roedor e de um anticorpo em um roedor. |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US10820582B2 (pt) |
| EP (3) | EP3407709B9 (pt) |
| JP (4) | JP6884860B2 (pt) |
| KR (4) | KR20240055863A (pt) |
| CN (2) | CN109996441B (pt) |
| AU (2) | AU2017391167B2 (pt) |
| BR (1) | BR112019008675A2 (pt) |
| CA (1) | CA3038720A1 (pt) |
| CY (1) | CY1123491T1 (pt) |
| DK (2) | DK3407709T3 (pt) |
| ES (2) | ES2915609T3 (pt) |
| HR (2) | HRP20220888T1 (pt) |
| HU (2) | HUE052087T2 (pt) |
| IL (2) | IL308197A (pt) |
| LT (2) | LT3407709T (pt) |
| MA (2) | MA44091A (pt) |
| MX (2) | MX2019005256A (pt) |
| PL (2) | PL3407709T3 (pt) |
| PT (2) | PT3766343T (pt) |
| RS (2) | RS60886B1 (pt) |
| RU (2) | RU2021129958A (pt) |
| SG (2) | SG10201913483XA (pt) |
| SI (2) | SI3407709T1 (pt) |
| WO (1) | WO2018128691A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE046744T2 (hu) * | 2012-02-01 | 2020-03-30 | Regeneron Pharma | VL doméneket tartalmazó nehézláncokat expresszáló humanizált egér |
| WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
| CN109996441B (zh) | 2016-11-04 | 2022-02-08 | 瑞泽恩制药公司 | 具有经工程化的免疫球蛋白λ轻链基因座的非人类动物 |
| CN116874591A (zh) | 2018-03-24 | 2023-10-13 | 瑞泽恩制药公司 | 用于产生针对肽-mhc复合物的治疗性抗体的经过基因修饰的非人动物、其制造方法和用途 |
| AU2019242586A1 (en) | 2018-03-26 | 2020-10-01 | Regeneron Pharmaceuticals, Inc. | Humanized rodents for testing therapeutic agents |
| US20190380316A1 (en) | 2018-06-14 | 2019-12-19 | Regeneron Pharmaceuticals, Inc. | Non-human animals capable of engineered dh-dh rearrangement and uses thereof |
| WO2020172505A1 (en) | 2019-02-22 | 2020-08-27 | Regeneron Pharmaceuticals, Inc. | Rodents having genetically modified sodium channels and methods of use thereof |
| JP2022538885A (ja) * | 2019-07-01 | 2022-09-06 | トリアニ・インコーポレイテッド | トランスジェニック哺乳動物およびその使用法 |
| IL301137A (en) | 2020-09-11 | 2023-05-01 | Regeneron Pharma | Identification and production of antigen-specific antibodies |
| KR20230147048A (ko) | 2020-12-16 | 2023-10-20 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 Fc 알파 수용체를 발현하는 마우스 |
| CN116635413A (zh) | 2020-12-23 | 2023-08-22 | 再生元制药公司 | 用于获得结合跨膜蛋白的抗体的方法和生产所述抗体的细胞 |
| EP4051700A1 (en) | 2020-12-23 | 2022-09-07 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO1993012227A1 (en) * | 1991-12-17 | 1993-06-24 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| WO2003047336A2 (en) | 2001-11-30 | 2003-06-12 | Abgenix, Inc. | TRANSGENIC ANIMALS BEARING HUMAN Igμ LIGHT CHAIN GENES |
| WO2005007696A2 (en) * | 2003-07-15 | 2005-01-27 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
| ES2398076T3 (es) | 2006-06-02 | 2013-03-13 | Regeneron Pharmaceuticals, Inc. | Anticuerpos de alta afinidad contra el receptor de IL-6 humano |
| US9346873B2 (en) | 2008-09-30 | 2016-05-24 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
| CN112715482B (zh) * | 2008-12-18 | 2022-11-11 | 伊拉兹马斯大学鹿特丹医学中心 | 表达人源化抗体的非人转基因动物及其用途 |
| PL2564695T3 (pl) * | 2009-07-08 | 2015-10-30 | Kymab Ltd | Modele zwierzęce i cząsteczki terapeutyczne |
| US20120204278A1 (en) * | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| WO2011115476A1 (en) | 2010-03-17 | 2011-09-22 | N.V. Nutricia | Infant nutrition for improving fatty acid composition of brain membranes later in life |
| SI2480676T1 (sl) | 2010-06-22 | 2016-10-28 | Regeneron Pharmaceuticals, Inc. | Hibridna mišja lahka veriga |
| RS59413B2 (sr) | 2011-02-25 | 2023-06-30 | Regeneron Pharma | Adam6 miševi |
| DK2627773T3 (en) | 2011-10-17 | 2017-10-02 | Regeneron Pharma | MOUSE WITH LIMITED IMMUNOGLOBULIN HEAVY CHAIN |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| KR102038974B1 (ko) * | 2011-12-20 | 2019-10-31 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 경쇄 마우스 |
| SI2840892T1 (en) * | 2013-02-20 | 2018-08-31 | Regeneron Pharmaceuticals, Inc. | Animals other than humans with modified immunoglobulin heavy chain sequences |
| MX2015010841A (es) | 2013-02-20 | 2016-05-09 | Regeneron Pharma | Modificacion genetica de ratas. |
| US9788534B2 (en) * | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| CA2925723A1 (en) * | 2013-10-01 | 2015-04-09 | Kymab Limited | Animal models and therapeutic molecules |
| RU2685914C1 (ru) | 2013-12-11 | 2019-04-23 | Регенерон Фармасьютикалс, Инк. | Способы и композиции для направленной модификации генома |
| KR102374379B1 (ko) | 2014-06-06 | 2022-03-17 | 리제너론 파마슈티칼스 인코포레이티드 | 표적화된 좌를 변형시키는 방법 및 조성물 |
| EP3155099B1 (en) | 2014-06-23 | 2018-03-21 | Regeneron Pharmaceuticals, Inc. | Nuclease-mediated dna assembly |
| NZ731962A (en) | 2014-11-21 | 2022-07-01 | Regeneron Pharma | Methods and compositions for targeted genetic modification using paired guide rnas |
| MX2017008190A (es) | 2014-12-19 | 2018-03-23 | Regeneron Pharma | Metodos y composiciones para la modificacion genetica dirigida a traves de direccionamiento multiple de una sola etapa. |
| CN109996441B (zh) | 2016-11-04 | 2022-02-08 | 瑞泽恩制药公司 | 具有经工程化的免疫球蛋白λ轻链基因座的非人类动物 |
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2017
- 2017-11-03 CN CN201780067880.6A patent/CN109996441B/zh active Active
- 2017-11-03 WO PCT/US2017/060006 patent/WO2018128691A1/en active Application Filing
- 2017-11-03 KR KR1020247012338A patent/KR20240055863A/ko active Search and Examination
- 2017-11-03 KR KR1020197015717A patent/KR102319069B1/ko active IP Right Grant
- 2017-11-03 PT PT201805082T patent/PT3766343T/pt unknown
- 2017-11-03 SG SG10201913483XA patent/SG10201913483XA/en unknown
- 2017-11-03 DK DK17863293.1T patent/DK3407709T3/da active
- 2017-11-03 EP EP17863293.1A patent/EP3407709B9/en active Active
- 2017-11-03 MX MX2019005256A patent/MX2019005256A/es unknown
- 2017-11-03 US US15/803,513 patent/US10820582B2/en active Active
- 2017-11-03 SG SG11201903344XA patent/SG11201903344XA/en unknown
- 2017-11-03 PL PL17863293T patent/PL3407709T3/pl unknown
- 2017-11-03 AU AU2017391167A patent/AU2017391167B2/en active Active
- 2017-11-03 RS RS20201205A patent/RS60886B1/sr unknown
- 2017-11-03 KR KR1020237002504A patent/KR102658529B1/ko active IP Right Grant
- 2017-11-03 MA MA044091A patent/MA44091A/fr unknown
- 2017-11-03 SI SI201730381T patent/SI3407709T1/sl unknown
- 2017-11-03 PT PT178632931T patent/PT3407709T/pt unknown
- 2017-11-03 IL IL308197A patent/IL308197A/en unknown
- 2017-11-03 KR KR1020217034468A patent/KR102492433B1/ko active IP Right Grant
- 2017-11-03 DK DK20180508.2T patent/DK3766343T3/da active
- 2017-11-03 SI SI201731147T patent/SI3766343T1/sl unknown
- 2017-11-03 HR HRP20220888TT patent/HRP20220888T1/hr unknown
- 2017-11-03 ES ES20180508T patent/ES2915609T3/es active Active
- 2017-11-03 MA MA053935A patent/MA53935A/fr unknown
- 2017-11-03 CA CA3038720A patent/CA3038720A1/en active Pending
- 2017-11-03 ES ES17863293T patent/ES2823305T3/es active Active
- 2017-11-03 RS RS20220669A patent/RS63390B1/sr unknown
- 2017-11-03 HU HUE17863293A patent/HUE052087T2/hu unknown
- 2017-11-03 CN CN202210050898.8A patent/CN114369157A/zh active Pending
- 2017-11-03 JP JP2019522647A patent/JP6884860B2/ja active Active
- 2017-11-03 LT LTEP17863293.1T patent/LT3407709T/lt unknown
- 2017-11-03 HU HUE20180508A patent/HUE061980T2/hu unknown
- 2017-11-03 BR BR112019008675A patent/BR112019008675A2/pt unknown
- 2017-11-03 EP EP20180508.2A patent/EP3766343B1/en active Active
- 2017-11-03 EP EP22164751.4A patent/EP4082334A1/en active Pending
- 2017-11-03 PL PL20180508.2T patent/PL3766343T3/pl unknown
- 2017-11-03 RU RU2021129958A patent/RU2021129958A/ru unknown
- 2017-11-03 RU RU2019112589A patent/RU2757665C2/ru active
- 2017-11-03 IL IL266282A patent/IL266282B2/en unknown
- 2017-11-03 LT LTEP20180508.2T patent/LT3766343T/lt unknown
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2019
- 2019-05-03 MX MX2021010556A patent/MX2021010556A/es unknown
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2020
- 2020-09-03 HR HRP20201403TT patent/HRP20201403T1/hr unknown
- 2020-09-24 US US17/031,367 patent/US20210029978A1/en active Pending
- 2020-10-29 CY CY20201101022T patent/CY1123491T1/el unknown
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2021
- 2021-03-08 JP JP2021036180A patent/JP2021090455A/ja not_active Withdrawn
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2022
- 2022-07-07 JP JP2022109658A patent/JP7386292B2/ja active Active
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2023
- 2023-02-17 JP JP2023023312A patent/JP2023053400A/ja active Pending
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2024
- 2024-01-31 AU AU2024200582A patent/AU2024200582A1/en active Pending
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