JP2013532974A5 - - Google Patents
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- JP2013532974A5 JP2013532974A5 JP2013516714A JP2013516714A JP2013532974A5 JP 2013532974 A5 JP2013532974 A5 JP 2013532974A5 JP 2013516714 A JP2013516714 A JP 2013516714A JP 2013516714 A JP2013516714 A JP 2013516714A JP 2013532974 A5 JP2013532974 A5 JP 2013532974A5
- Authority
- JP
- Japan
- Prior art keywords
- mouse
- human
- light chain
- gene
- endogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35731410P | 2010-06-22 | 2010-06-22 | |
| US35731710P | 2010-06-22 | 2010-06-22 | |
| US61/357,314 | 2010-06-22 | ||
| US61/357,317 | 2010-06-22 | ||
| PCT/US2011/041366 WO2011163311A1 (en) | 2010-06-22 | 2011-06-22 | Mice expressing alight chain with human lambda variable and mouse constant regions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015205321A Division JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532974A JP2013532974A (ja) | 2013-08-22 |
| JP2013532974A5 true JP2013532974A5 (enExample) | 2014-07-17 |
| JP5988969B2 JP5988969B2 (ja) | 2016-09-07 |
Family
ID=44509861
Family Applications (17)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516716A Active JP6009441B2 (ja) | 2010-06-22 | 2011-06-22 | ハイブリッド軽鎖マウス |
| JP2013516714A Active JP5988969B2 (ja) | 2010-06-22 | 2011-06-22 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2015205439A Active JP6073441B2 (ja) | 2010-06-22 | 2015-10-19 | ハイブリッド軽鎖マウス |
| JP2015205321A Active JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016204854A Withdrawn JP2017006152A (ja) | 2010-06-22 | 2016-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016208582A Active JP6341972B2 (ja) | 2010-06-22 | 2016-10-25 | ハイブリッド軽鎖マウス |
| JP2017222512A Active JP6545773B2 (ja) | 2010-06-22 | 2017-11-20 | ハイブリッド軽鎖マウス |
| JP2018188846A Pending JP2018201527A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018188847A Pending JP2018201528A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018228851A Active JP6963542B2 (ja) | 2010-06-22 | 2018-12-06 | ハイブリッド軽鎖マウス |
| JP2020015538A Withdrawn JP2020062061A (ja) | 2010-06-22 | 2020-01-31 | ハイブリッド軽鎖マウス |
| JP2020098480A Active JP7236409B2 (ja) | 2010-06-22 | 2020-06-05 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2021009451A Withdrawn JP2021061863A (ja) | 2010-06-22 | 2021-01-25 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2022034415A Withdrawn JP2022066449A (ja) | 2010-06-22 | 2022-03-07 | ハイブリッド軽鎖マウス |
| JP2023127047A Withdrawn JP2023133554A (ja) | 2010-06-22 | 2023-08-03 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2024214653A Pending JP2025027148A (ja) | 2010-06-22 | 2024-12-09 | ハイブリッド軽鎖マウス |
| JP2026022125A Pending JP2026066390A (ja) | 2010-06-22 | 2026-02-13 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516716A Active JP6009441B2 (ja) | 2010-06-22 | 2011-06-22 | ハイブリッド軽鎖マウス |
Family Applications After (15)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015205439A Active JP6073441B2 (ja) | 2010-06-22 | 2015-10-19 | ハイブリッド軽鎖マウス |
| JP2015205321A Active JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016204854A Withdrawn JP2017006152A (ja) | 2010-06-22 | 2016-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016208582A Active JP6341972B2 (ja) | 2010-06-22 | 2016-10-25 | ハイブリッド軽鎖マウス |
| JP2017222512A Active JP6545773B2 (ja) | 2010-06-22 | 2017-11-20 | ハイブリッド軽鎖マウス |
| JP2018188846A Pending JP2018201527A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018188847A Pending JP2018201528A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018228851A Active JP6963542B2 (ja) | 2010-06-22 | 2018-12-06 | ハイブリッド軽鎖マウス |
| JP2020015538A Withdrawn JP2020062061A (ja) | 2010-06-22 | 2020-01-31 | ハイブリッド軽鎖マウス |
| JP2020098480A Active JP7236409B2 (ja) | 2010-06-22 | 2020-06-05 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2021009451A Withdrawn JP2021061863A (ja) | 2010-06-22 | 2021-01-25 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2022034415A Withdrawn JP2022066449A (ja) | 2010-06-22 | 2022-03-07 | ハイブリッド軽鎖マウス |
| JP2023127047A Withdrawn JP2023133554A (ja) | 2010-06-22 | 2023-08-03 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2024214653A Pending JP2025027148A (ja) | 2010-06-22 | 2024-12-09 | ハイブリッド軽鎖マウス |
| JP2026022125A Pending JP2026066390A (ja) | 2010-06-22 | 2026-02-13 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
Country Status (30)
| Country | Link |
|---|---|
| US (22) | US9035128B2 (enExample) |
| EP (7) | EP2568049B1 (enExample) |
| JP (17) | JP6009441B2 (enExample) |
| KR (16) | KR101970944B1 (enExample) |
| CN (4) | CN103068994B (enExample) |
| AU (1) | AU2011271046B2 (enExample) |
| BR (3) | BR112012032991B1 (enExample) |
| CA (2) | CA2804311C (enExample) |
| CY (5) | CY1117537T1 (enExample) |
| DK (5) | DK2905338T3 (enExample) |
| ES (5) | ES2570131T3 (enExample) |
| HR (5) | HRP20160794T1 (enExample) |
| HU (5) | HUE029691T2 (enExample) |
| IL (12) | IL313063A (enExample) |
| LT (4) | LT3034608T (enExample) |
| ME (5) | ME02440B (enExample) |
| MX (6) | MX347322B (enExample) |
| MY (6) | MY195214A (enExample) |
| NO (1) | NO2905338T3 (enExample) |
| NZ (6) | NZ627119A (enExample) |
| PL (5) | PL2480675T3 (enExample) |
| PT (5) | PT3034608T (enExample) |
| RS (5) | RS55037B1 (enExample) |
| RU (3) | RU2724736C2 (enExample) |
| SG (4) | SG10201504324UA (enExample) |
| SI (5) | SI2480675T1 (enExample) |
| SM (5) | SMT201900241T1 (enExample) |
| TR (1) | TR201905992T4 (enExample) |
| WO (2) | WO2011163314A1 (enExample) |
| ZA (5) | ZA201300062B (enExample) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| WO2010039900A2 (en) | 2008-09-30 | 2010-04-08 | Aliva Biopharmaceuticals, Inc. | Non-human mammals for the production of chimeric antibodies |
| CA2747534C (en) | 2008-12-18 | 2020-08-18 | Erasmus University Medical Center Rotterdam | Non-human transgenic animals expressing humanised antibodies and use therof |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| CN102638971B (zh) | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| HRP20151188T4 (hr) | 2010-02-08 | 2021-10-01 | Regeneron Pharmaceuticals, Inc. | Miš sa zajedničkim lakim lancem |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| PL3251503T3 (pl) | 2010-03-31 | 2024-07-08 | Ablexis, Llc | Modyfikacja myszy metodami inżynierii genetycznej w celu wytworzenia przeciwciał chimerycznych |
| SI2480675T1 (sl) | 2010-06-22 | 2016-08-31 | Regeneron Pharmaceuticals, Inc. | Miši, ki izražajo lahko verigo s spremenljivo regijo humanega lambda in konstantno mišjo regijo |
| US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| RU2580017C2 (ru) | 2010-07-26 | 2016-04-10 | Трианни, Инк. | Трансгенные животные и способы применения |
| KR102306967B1 (ko) | 2010-08-02 | 2021-10-01 | 리제너론 파아마슈티컬스, 인크. | Ｖｌ 도메인을 포함하는 결합 단백질을 생성하는 마우스 |
| PT3865581T (pt) | 2011-08-05 | 2024-10-04 | Regeneron Pharma | Murganhos da cadeia leve universal humanizada |
| AU2012311286B2 (en) | 2011-09-19 | 2018-07-26 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| EP3741862A1 (en) | 2011-09-19 | 2020-11-25 | Kymab Limited | Animals, repertoires & methods for the production of human antibodies |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| PT3527070T (pt) | 2011-12-20 | 2025-12-19 | Regeneron Pharma | Murganhos de cadeia leve humanizada |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| HK1200271A1 (en) | 2012-03-16 | 2015-08-07 | 瑞泽恩制药公司 | Mice that produce antigen-binding proteins with ph-dependent binding characteristics |
| KR102213535B1 (ko) | 2012-03-16 | 2021-02-08 | 리제너론 파마슈티칼스 인코포레이티드 | pH-민감성 면역글로불린 서열을 발현하는 비-사람 동물 |
| DK2825036T3 (en) | 2012-03-16 | 2018-07-16 | Regeneron Pharma | Histidine engineered light chain antibodies and genetically modified rodents to generate them |
| EP2831245A1 (en) | 2012-03-28 | 2015-02-04 | Kymab Limited | Transgenic non-human vertebrate for the expression of class - switched, fully human, antibodies |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) * | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| MY185881A (en) | 2013-02-20 | 2021-06-14 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
| EP4218409B1 (en) * | 2013-03-13 | 2025-02-12 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| PL2967012T3 (pl) | 2013-03-14 | 2021-04-19 | Erasmus University Medical Center Rotterdam | Transgeniczne ssaki inne niż człowiek do wytwarzania przeciwciał |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| JP6621750B2 (ja) * | 2013-09-18 | 2019-12-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒスチジン操作軽鎖抗体およびそれを生成するための遺伝子改変非ヒト動物 |
| CA2925723A1 (en) | 2013-10-01 | 2015-04-09 | Kymab Limited | Animal models and therapeutic molecules |
| US20170101460A1 (en) * | 2014-01-10 | 2017-04-13 | Allermabs Co. Ltd. | Transgenic animals capable of producing humanized ige at much higher levels than mouse ige |
| CN106164092A (zh) * | 2014-03-21 | 2016-11-23 | 瑞泽恩制药公司 | 表现不同结合特征的vl抗原结合蛋白 |
| CN106255410B (zh) | 2014-03-21 | 2020-01-10 | 瑞泽恩制药公司 | 产生单结构域结合蛋白的非人动物 |
| AU2015271709B2 (en) | 2014-06-06 | 2020-11-26 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof |
| KR20170083534A (ko) | 2014-09-19 | 2017-07-18 | 리제너론 파마슈티칼스 인코포레이티드 | 키메라 항원 수용체 |
| SG10201902924RA (en) | 2014-10-03 | 2019-05-30 | Massachusetts Inst Technology | Antibodies that bind ebola glycoprotein and uses thereof |
| TWI711630B (zh) | 2014-11-21 | 2020-12-01 | 美商必治妥美雅史谷比公司 | 抗ｃｄ７３抗體及其用途 |
| CN107278206B (zh) | 2014-12-19 | 2021-04-02 | 雷根尼桑斯公司 | 结合人c6的抗体及其用途 |
| MY187045A (en) | 2014-12-23 | 2021-08-27 | Bristol Myers Squibb Co | Antibodies to tigit |
| WO2016124709A1 (de) | 2015-02-05 | 2016-08-11 | Basf Se | Solarkraftwerk mit einem ersten wärmeträgerkreislauf und einem zweiten wärmeträgerkreislauf |
| US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| EA035412B1 (ru) | 2015-05-29 | 2020-06-10 | Бристол-Майерс Сквибб Компани | Антитела к ox40 и их применение |
| US10479838B2 (en) | 2015-06-29 | 2019-11-19 | Bristol-Myers Squibb Company | Antibodies to CD40 with enhanced agonist activity |
| CN105274116B (zh) * | 2015-10-21 | 2020-09-29 | 重庆金迈博生物科技有限公司 | 一种制备人源化抗体的核酸分子及其应用 |
| CA3005855A1 (en) | 2015-11-19 | 2017-05-26 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof |
| WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
| AU2017213633B2 (en) | 2016-02-04 | 2023-08-03 | Trianni, Inc. | Enhanced production of immunoglobulins |
| CA3016187A1 (en) | 2016-03-04 | 2017-09-08 | Bristol-Myers Squibb Company | Combination therapy with anti-cd73 antibodies |
| KR20180114223A (ko) | 2016-03-04 | 2018-10-17 | 더 락커펠러 유니버시티 | 증진된 효능제 활성을 갖는 cd40에 대한 항체 |
| US10968279B2 (en) | 2016-05-09 | 2021-04-06 | Bristol-Myers Squibb Company | TL1A antibodies and uses thereof |
| US20170332610A1 (en) | 2016-05-20 | 2017-11-23 | Regeneron Pharmaceuticals, Inc. | Methods for breaking immunological tolerance using multiple guide rnas |
| KR102483193B1 (ko) | 2016-06-03 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 외인성 말단 데옥시뉴클레오타이드 전달효소를 발현하는 비인간 동물 |
| WO2017214089A1 (en) | 2016-06-06 | 2017-12-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing antibodies with human lambda light chains |
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| SG11201900026TA (en) | 2016-07-14 | 2019-01-30 | Bristol Myers Squibb Co | Antibodies against tim3 and uses thereof |
| US10981976B2 (en) | 2016-08-31 | 2021-04-20 | University Of Rochester | Human monoclonal antibodies to human endogenous retrovirus K envelope (HERV-K) and use thereof |
| CA3040189A1 (en) | 2016-10-13 | 2018-04-19 | Massachusetts Institute Of Technology | Antibodies that bind zika virus envelope protein and uses thereof |
| CN109906272A (zh) | 2016-10-31 | 2019-06-18 | 国立大学法人鸟取大学 | 产生人抗体的非人动物和使用该非人动物的人抗体制作方法 |
| PT4082334T (pt) | 2016-11-04 | 2025-05-21 | Regeneron Pharma | Animais não humanos possuindo um lócus da cadeia leve lambda de immunoglobulina geneticamente modificada |
| EA201991720A1 (ru) | 2017-02-17 | 2020-01-20 | Бристол-Маерс Сквибб Компани | Антитела к альфа-синуклеину и их применения |
| TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
| TW202438676A (zh) | 2017-12-05 | 2024-10-01 | 美商再生元醫藥公司 | 具有經改造免疫球蛋白λ輕鏈的非人類動物及其用途 |
| JP7358361B2 (ja) | 2018-01-12 | 2023-10-10 | ブリストル－マイヤーズ スクイブ カンパニー | Ｔｉｍ３に対する抗体およびその使用 |
| CA3093407A1 (en) | 2018-03-23 | 2019-09-26 | Bristol-Myers Squibb Company | Antibodies against mica and/or micb and uses thereof |
| SG11202008799PA (en) | 2018-03-24 | 2020-10-29 | Regeneron Pharma | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| WO2019190990A1 (en) | 2018-03-26 | 2019-10-03 | Regeneron Pharmaceuticals, Inc. | Humanized rodents for testing therapeutic agents |
| WO2019236671A1 (en) * | 2018-06-08 | 2019-12-12 | Crystal Bioscience Inc. | Transgenic animal for producing diversified antibodies that have the same light chain ii |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| US20220003822A1 (en) | 2018-10-26 | 2022-01-06 | Vehicle Energy Japan Inc. | Battery control device |
| BR112021009111A2 (pt) | 2018-11-16 | 2021-08-24 | Bristol-Myers Squibb Company | Anticorpos anti-nkg2a e usos dos mesmos |
| EP3914622A1 (en) | 2019-01-22 | 2021-12-01 | Bristol-Myers Squibb Company | Antibodies against il-7r alpha subunit and uses thereof |
| SG11202107589PA (en) | 2019-02-22 | 2021-08-30 | Regeneron Pharma | Rodents having genetically modified sodium channels and methods of use thereof |
| SG11202111258TA (en) * | 2019-06-05 | 2021-11-29 | Regeneron Pharma | Non-human animals having a limited lambda light chain repertoire expressed from the kappa locus and uses thereof |
| FI3993623T3 (fi) * | 2019-07-01 | 2025-05-25 | Zoetis Services Llc | Muuntogeeniset jyrsijät ja niiden käyttömenetelmät |
| IL293330A (en) | 2019-12-02 | 2022-07-01 | Regeneron Pharma | mhc ii peptide protein structures and uses thereof |
| WO2021231732A1 (en) | 2020-05-15 | 2021-11-18 | Bristol-Myers Squibb Company | Antibodies to garp |
| WO2021261620A1 (ko) * | 2020-06-25 | 2021-12-30 | 주식회사 휴맵 | 이형접합성 형질전환 동물 |
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