JP2013532974A5 - - Google Patents
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- JP2013532974A5 JP2013532974A5 JP2013516714A JP2013516714A JP2013532974A5 JP 2013532974 A5 JP2013532974 A5 JP 2013532974A5 JP 2013516714 A JP2013516714 A JP 2013516714A JP 2013516714 A JP2013516714 A JP 2013516714A JP 2013532974 A5 JP2013532974 A5 JP 2013532974A5
- Authority
- JP
- Japan
- Prior art keywords
- mouse
- human
- light chain
- gene
- endogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35731410P | 2010-06-22 | 2010-06-22 | |
| US35731710P | 2010-06-22 | 2010-06-22 | |
| US61/357,317 | 2010-06-22 | ||
| US61/357,314 | 2010-06-22 | ||
| PCT/US2011/041366 WO2011163311A1 (en) | 2010-06-22 | 2011-06-22 | Mice expressing alight chain with human lambda variable and mouse constant regions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015205321A Division JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532974A JP2013532974A (ja) | 2013-08-22 |
| JP2013532974A5 true JP2013532974A5 (enExample) | 2014-07-17 |
| JP5988969B2 JP5988969B2 (ja) | 2016-09-07 |
Family
ID=44509861
Family Applications (17)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516714A Active JP5988969B2 (ja) | 2010-06-22 | 2011-06-22 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2013516716A Active JP6009441B2 (ja) | 2010-06-22 | 2011-06-22 | ハイブリッド軽鎖マウス |
| JP2015205439A Active JP6073441B2 (ja) | 2010-06-22 | 2015-10-19 | ハイブリッド軽鎖マウス |
| JP2015205321A Active JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016204854A Withdrawn JP2017006152A (ja) | 2010-06-22 | 2016-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016208582A Active JP6341972B2 (ja) | 2010-06-22 | 2016-10-25 | ハイブリッド軽鎖マウス |
| JP2017222512A Active JP6545773B2 (ja) | 2010-06-22 | 2017-11-20 | ハイブリッド軽鎖マウス |
| JP2018188847A Pending JP2018201528A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018188846A Pending JP2018201527A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018228851A Active JP6963542B2 (ja) | 2010-06-22 | 2018-12-06 | ハイブリッド軽鎖マウス |
| JP2020015538A Withdrawn JP2020062061A (ja) | 2010-06-22 | 2020-01-31 | ハイブリッド軽鎖マウス |
| JP2020098480A Active JP7236409B2 (ja) | 2010-06-22 | 2020-06-05 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2021009451A Withdrawn JP2021061863A (ja) | 2010-06-22 | 2021-01-25 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2022034415A Withdrawn JP2022066449A (ja) | 2010-06-22 | 2022-03-07 | ハイブリッド軽鎖マウス |
| JP2023127047A Withdrawn JP2023133554A (ja) | 2010-06-22 | 2023-08-03 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2024214653A Pending JP2025027148A (ja) | 2010-06-22 | 2024-12-09 | ハイブリッド軽鎖マウス |
| JP2026022125A Pending JP2026066390A (ja) | 2010-06-22 | 2026-02-13 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
Family Applications After (16)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013516716A Active JP6009441B2 (ja) | 2010-06-22 | 2011-06-22 | ハイブリッド軽鎖マウス |
| JP2015205439A Active JP6073441B2 (ja) | 2010-06-22 | 2015-10-19 | ハイブリッド軽鎖マウス |
| JP2015205321A Active JP6243384B2 (ja) | 2010-06-22 | 2015-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016204854A Withdrawn JP2017006152A (ja) | 2010-06-22 | 2016-10-19 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2016208582A Active JP6341972B2 (ja) | 2010-06-22 | 2016-10-25 | ハイブリッド軽鎖マウス |
| JP2017222512A Active JP6545773B2 (ja) | 2010-06-22 | 2017-11-20 | ハイブリッド軽鎖マウス |
| JP2018188847A Pending JP2018201528A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018188846A Pending JP2018201527A (ja) | 2010-06-22 | 2018-10-04 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2018228851A Active JP6963542B2 (ja) | 2010-06-22 | 2018-12-06 | ハイブリッド軽鎖マウス |
| JP2020015538A Withdrawn JP2020062061A (ja) | 2010-06-22 | 2020-01-31 | ハイブリッド軽鎖マウス |
| JP2020098480A Active JP7236409B2 (ja) | 2010-06-22 | 2020-06-05 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2021009451A Withdrawn JP2021061863A (ja) | 2010-06-22 | 2021-01-25 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2022034415A Withdrawn JP2022066449A (ja) | 2010-06-22 | 2022-03-07 | ハイブリッド軽鎖マウス |
| JP2023127047A Withdrawn JP2023133554A (ja) | 2010-06-22 | 2023-08-03 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
| JP2024214653A Pending JP2025027148A (ja) | 2010-06-22 | 2024-12-09 | ハイブリッド軽鎖マウス |
| JP2026022125A Pending JP2026066390A (ja) | 2010-06-22 | 2026-02-13 | ヒトλ可変領域およびマウス定常領域を含む軽鎖を発現するマウス |
Country Status (30)
| Country | Link |
|---|---|
| US (22) | US9035128B2 (enExample) |
| EP (7) | EP2568049B1 (enExample) |
| JP (17) | JP5988969B2 (enExample) |
| KR (16) | KR102211911B1 (enExample) |
| CN (4) | CN104342455B (enExample) |
| AU (1) | AU2011271046B2 (enExample) |
| BR (3) | BR112012032991B1 (enExample) |
| CA (2) | CA2803864C (enExample) |
| CY (5) | CY1117537T1 (enExample) |
| DK (5) | DK2480676T3 (enExample) |
| ES (5) | ES2575223T3 (enExample) |
| HR (5) | HRP20160794T1 (enExample) |
| HU (5) | HUE036597T2 (enExample) |
| IL (12) | IL313063A (enExample) |
| LT (4) | LT2905338T (enExample) |
| ME (5) | ME02444B (enExample) |
| MX (6) | MX347318B (enExample) |
| MY (6) | MY165287A (enExample) |
| NO (1) | NO2905338T3 (enExample) |
| NZ (6) | NZ627119A (enExample) |
| PL (5) | PL2480675T3 (enExample) |
| PT (5) | PT3034608T (enExample) |
| RS (5) | RS56589B1 (enExample) |
| RU (3) | RU2590594C2 (enExample) |
| SG (4) | SG186390A1 (enExample) |
| SI (5) | SI2905338T1 (enExample) |
| SM (5) | SMT201700506T1 (enExample) |
| TR (1) | TR201905992T4 (enExample) |
| WO (2) | WO2011163311A1 (enExample) |
| ZA (5) | ZA201300062B (enExample) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| AU2009298458B2 (en) | 2008-09-30 | 2015-10-08 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
| JP5827127B2 (ja) | 2008-12-18 | 2015-12-02 | エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム | ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用 |
| US9445581B2 (en) * | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| DK3622815T3 (da) | 2009-07-08 | 2023-06-26 | Kymab Ltd | Gnavermodeller og terapeutiske molekyler |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| SMT202600080T1 (it) | 2010-02-08 | 2026-03-09 | Regeneron Pharma | Topo con catena leggera comune |
| ES2984483T3 (es) | 2010-03-31 | 2024-10-29 | Ablexis Llc | Ingeniería genética de ratones para la producción de anticuerpos quiméricos |
| PT3034608T (pt) | 2010-06-22 | 2019-05-28 | Regeneron Pharma | Ratinhos expressando uma cadeia leve híbrida de imunoglobulina com uma região variável humana |
| CN103025884B (zh) | 2010-07-26 | 2015-11-25 | 特里安尼公司 | 转基因动物和使用方法 |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| SMT201700023T1 (it) | 2010-08-02 | 2017-03-08 | Regeneron Pharma | Topi che producono proteine leganti vl |
| HUE047278T2 (hu) | 2011-08-05 | 2020-04-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
| BR112014006394A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
| EP2758534B1 (en) | 2011-09-19 | 2020-04-29 | Kymab Limited | Animals, repertoires & methods for the production of human antibodies |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| US9253965B2 (en) * | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| SG10201605675WA (en) * | 2011-12-20 | 2016-09-29 | Regeneron Pharma | Humanized light chain mice |
| EP2825036B1 (en) | 2012-03-16 | 2018-05-02 | Regeneron Pharmaceuticals, Inc. | Histidine engineered light chain antibodies and genetically modified rodents for generating the same |
| WO2013138681A1 (en) | 2012-03-16 | 2013-09-19 | Regeneron Pharmaceuticals, Inc. | Mice that produce antigen-binding proteins with ph-dependent binding characteristics |
| EP3539374A1 (en) | 2012-03-16 | 2019-09-18 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing ph-sensitive immunoglobulin sequences |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| SG11201405059XA (en) | 2012-03-28 | 2014-09-26 | Kymab Ltd | Transgenic non-human vertebrate for the expression of class - switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| MY178882A (en) | 2013-02-20 | 2020-10-21 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
| EP4545567A3 (en) * | 2013-03-13 | 2025-08-13 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| EP3841876A1 (en) | 2013-03-14 | 2021-06-30 | Erasmus University Medical Center Rotterdam | Transgenic mouse for antibody production |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| RU2019121863A (ru) * | 2013-09-18 | 2019-08-29 | Регенерон Фармасьютикалз, Инк. | Антитела со встроенным в легкие цепи гистидином и генетически модифицированные отличные от человека животные для их получения |
| AU2014330922A1 (en) | 2013-10-01 | 2016-03-03 | Kymab Limited | Animal models and therapeutic molecules |
| TW201532513A (zh) * | 2014-01-10 | 2015-09-01 | Alfur Fu-Hsin Hung | 能產生比小鼠ＩgＥ量高出許多的人源化ＩgＥ之基因轉殖動物 |
| CA3124228C (en) | 2014-03-21 | 2024-05-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| AU2015231025A1 (en) * | 2014-03-21 | 2016-09-15 | Regeneron Pharmaceuticals, Inc. | Vl antigen binding proteins exhibiting distinct binding characteristics |
| PE20170441A1 (es) | 2014-06-06 | 2017-04-26 | Bristol Myers Squibb Co | Anticuerpos contra el receptor del factor de necrosis tumoral inducido por glucocorticoides (gitr) y sus usos |
| JP2017529841A (ja) | 2014-09-19 | 2017-10-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | キメラ抗原受容体 |
| JP2017531642A (ja) | 2014-10-03 | 2017-10-26 | マサチューセッツ インスティテュート オブ テクノロジー | エボラ糖タンパク質に結合する抗体およびその使用 |
| AU2015349878A1 (en) | 2014-11-21 | 2017-05-25 | Bristol-Myers Squibb Company | Antibodies against CD73 and uses thereof |
| WO2016097865A1 (en) | 2014-12-19 | 2016-06-23 | Regenesance B.V. | Antibodies that bind human c6 and uses thereof |
| JP6180663B2 (ja) | 2014-12-23 | 2017-08-16 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｔｉｇｉｔに対する抗体 |
| EP3254035B1 (de) | 2015-02-05 | 2019-01-30 | Basf Se | Solarkraftwerk mit einem ersten wärmeträgerkreislauf und einem zweiten wärmeträgerkreislauf |
| CA2979702A1 (en) | 2015-03-19 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| DK3303396T5 (da) | 2015-05-29 | 2024-10-07 | Bristol Myers Squibb Co | Antistoffer mod ox40 og anvendelser deraf |
| CN107922500A (zh) | 2015-06-29 | 2018-04-17 | 洛克菲勒大学 | 具有增强的激动剂活性的抗cd40抗体 |
| CN105274116B (zh) * | 2015-10-21 | 2020-09-29 | 重庆金迈博生物科技有限公司 | 一种制备人源化抗体的核酸分子及其应用 |
| AU2016356780A1 (en) | 2015-11-19 | 2018-06-28 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof |
| US10813346B2 (en) | 2015-12-03 | 2020-10-27 | Trianni, Inc. | Enhanced immunoglobulin diversity |
| EP4414484A3 (en) | 2016-02-04 | 2025-01-15 | Trianni, Inc. | Enhanced production of immunoglobulins |
| ES2985566T3 (es) | 2016-03-04 | 2024-11-06 | Univ Rockefeller | Anticuerpos contra CD40 con actividad agonista mejorada |
| EP3423494A1 (en) | 2016-03-04 | 2019-01-09 | Bristol-Myers Squibb Company | Combination therapy with anti-cd73 antibodies |
| MX392069B (es) | 2016-05-09 | 2025-03-21 | Bristol Myers Squibb Co | Anticuerpos del ligando similar al factor de necrosis tumoral 1a (tl1a) y usos de los mismos. |
| CN113831407B (zh) | 2016-05-20 | 2024-06-11 | 瑞泽恩制药公司 | 用于使用多个引导rna来破坏免疫耐受性的方法 |
| KR102483193B1 (ko) | 2016-06-03 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 외인성 말단 데옥시뉴클레오타이드 전달효소를 발현하는 비인간 동물 |
| WO2017214089A1 (en) | 2016-06-06 | 2017-12-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing antibodies with human lambda light chains |
| US20170371963A1 (en) * | 2016-06-27 | 2017-12-28 | Facebook, Inc. | Systems and methods for identifying matching content |
| CN109757103B (zh) | 2016-07-14 | 2024-01-02 | 百时美施贵宝公司 | 针对tim3的抗体及其用途 |
| US10981976B2 (en) | 2016-08-31 | 2021-04-20 | University Of Rochester | Human monoclonal antibodies to human endogenous retrovirus K envelope (HERV-K) and use thereof |
| MX2019004371A (es) | 2016-10-13 | 2019-11-18 | Massachusetts Inst Technology | Anticuerpos que se unen a la proteina de envoltura del virus zika y usos de los mismos. |
| EP3533867A4 (en) | 2016-10-31 | 2020-07-22 | National University Corporation Tottori University | NON-HUMAN ANIMAL PRODUCING HUMAN ANTIBODIES AND PROCESS FOR THE PREPARATION OF HUMAN ANTIBODIES USING IT |
| SG10201913483XA (en) * | 2016-11-04 | 2020-03-30 | Regeneron Pharma | Non-human animals having an engineered immunoglobulin lambda light chain locus |
| CA3051839A1 (en) | 2017-02-17 | 2018-08-23 | Bristol-Myers Squibb Company | Antibodies to alpha-synuclein and uses thereof |
| TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
| HUE060608T2 (hu) | 2017-12-05 | 2023-03-28 | Regeneron Pharma | Genetikailag módosított immunglobulin lambda könnyûlánccal rendelkezõ egerek és azok alkalmazása |
| EP3737700A1 (en) | 2018-01-12 | 2020-11-18 | Bristol-Myers Squibb Company | Antibodies against tim3 and uses thereof |
| EP3768715A1 (en) | 2018-03-23 | 2021-01-27 | Bristol-Myers Squibb Company | Antibodies against mica and/or micb and uses thereof |
| EP3772927B1 (en) | 2018-03-24 | 2025-01-15 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice or rats for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| IL314733A (en) | 2018-03-26 | 2024-10-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| JP7269963B2 (ja) * | 2018-06-08 | 2023-05-09 | クリスタル バイオサイエンス インコーポレイテッド | 同じ軽鎖ｉを有する多様な抗体を産生するためのトランスジェニック動物 |
| IL318469A (en) | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| CN112969929B (zh) | 2018-10-26 | 2024-06-21 | 日本汽车能源株式会社 | 电池控制装置 |
| CN113316590B (zh) | 2018-11-16 | 2025-02-28 | 百时美施贵宝公司 | 抗nkg2a抗体及其用途 |
| CN113396162B (zh) | 2019-01-22 | 2024-08-16 | 百时美施贵宝公司 | 抗IL-7Rα亚基的抗体及其用途 |
| BR112021016173A2 (pt) | 2019-02-22 | 2021-11-03 | Regeneron Pharma | Roedor geneticamente modificado, métodos de produção de um roedor geneticamente modificado e de produção de um anticorpo anti-nav1.7, célula ou tecido isolado de roedor, linhagem celular imortalizada, embrião de roedor, construto de ácido nucleico de direcionamento, e, hibridoma |
| MX2021014893A (es) * | 2019-06-05 | 2022-03-11 | Regeneron Pharma | Animales no humanos que tienen un repertorio de cadena ligera lambda limitado expresado a partir del locus kappa y usos de estos. |
| DK3993623T3 (da) * | 2019-07-01 | 2025-05-26 | Zoetis Services Llc | Transgene gnavere og fremgangsmåder til anvendelse deraf |
| US20220409732A1 (en) | 2019-12-02 | 2022-12-29 | Regeneron Pharmaceuticals, Inc. | Peptide-mhc ii protein constructs and uses thereof |
| US20230192867A1 (en) | 2020-05-15 | 2023-06-22 | Bristol-Myers Squibb Company | Antibodies to garp |
| WO2021261620A1 (ko) * | 2020-06-25 | 2021-12-30 | 주식회사 휴맵 | 이형접합성 형질전환 동물 |
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