JP2020504101A5 - - Google Patents

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JP2020504101A5
JP2020504101A5 JP2019531934A JP2019531934A JP2020504101A5 JP 2020504101 A5 JP2020504101 A5 JP 2020504101A5 JP 2019531934 A JP2019531934 A JP 2019531934A JP 2019531934 A JP2019531934 A JP 2019531934A JP 2020504101 A5 JP2020504101 A5 JP 2020504101A5
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seq
amino acid
acid sequence
antibody
host cell
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JP2019531934A
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JP6772385B2 (ja
JP2020504101A (ja
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Priority claimed from PCT/US2017/066680 external-priority patent/WO2018112346A1/en
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JP2019531934A 2016-12-15 2017-12-15 抗ox40抗体及びそれらの使用 Expired - Fee Related JP6772385B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662434761P 2016-12-15 2016-12-15
US62/434,761 2016-12-15
PCT/US2017/066680 WO2018112346A1 (en) 2016-12-15 2017-12-15 Anti-ox40 antibodies and their uses

Related Child Applications (1)

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JP2020162944A Division JP2021019603A (ja) 2016-12-15 2020-09-29 抗ox40抗体及びそれらの使用

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JP2020504101A JP2020504101A (ja) 2020-02-06
JP2020504101A5 true JP2020504101A5 (enExample) 2020-09-10
JP6772385B2 JP6772385B2 (ja) 2020-10-21

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JP2019531934A Expired - Fee Related JP6772385B2 (ja) 2016-12-15 2017-12-15 抗ox40抗体及びそれらの使用
JP2020162944A Pending JP2021019603A (ja) 2016-12-15 2020-09-29 抗ox40抗体及びそれらの使用

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US (7) US10556962B2 (enExample)
EP (2) EP3504242B1 (enExample)
JP (2) JP6772385B2 (enExample)
KR (2) KR102341926B1 (enExample)
CN (1) CN110573527A (enExample)
AR (1) AR110526A1 (enExample)
AU (1) AU2017377036B2 (enExample)
BR (2) BR112019012328A2 (enExample)
CA (1) CA3045940A1 (enExample)
CL (1) CL2019001646A1 (enExample)
CO (1) CO2019007288A2 (enExample)
CR (1) CR20190330A (enExample)
CY (1) CY1123274T1 (enExample)
DK (1) DK3504242T3 (enExample)
DO (1) DOP2019000165A (enExample)
EC (1) ECSP19050049A (enExample)
ES (1) ES2813057T3 (enExample)
HR (1) HRP20201259T1 (enExample)
HU (1) HUE050399T2 (enExample)
IL (1) IL267070A (enExample)
LT (1) LT3504242T (enExample)
MA (1) MA53184A (enExample)
MX (1) MX2019007121A (enExample)
MY (1) MY198059A (enExample)
PE (1) PE20191403A1 (enExample)
PH (1) PH12019501357A1 (enExample)
PL (1) PL3504242T3 (enExample)
PT (1) PT3504242T (enExample)
RS (1) RS60664B1 (enExample)
RU (1) RU2753493C2 (enExample)
SG (1) SG10201914126RA (enExample)
SI (1) SI3504242T1 (enExample)
SM (1) SMT202000462T1 (enExample)
TW (1) TWI734879B (enExample)
UA (1) UA125041C2 (enExample)
UY (1) UY37523A (enExample)
WO (1) WO2018112346A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3504242B1 (en) * 2016-12-15 2020-06-24 AbbVie Biotherapeutics Inc. Anti-ox40 antibodies and their uses
WO2018225035A1 (en) * 2017-06-09 2018-12-13 Glaxosmithkline Intellectual Property Development Limited Combination therapy with icos agonist and ox40 agonist to treat cancer
WO2019028182A2 (en) * 2017-08-01 2019-02-07 Remd Biotherapeutics, Inc. TREATMENT OF CANCER USING ANTIBODIES BINDING TO THE HUMAN CD134 RECEPTOR (OX40)
CN110790837A (zh) * 2018-08-02 2020-02-14 上海君实生物医药科技股份有限公司 抗btla抗体
WO2020119789A1 (en) * 2018-12-14 2020-06-18 Wuxi Biologics (Shanghai) Co., Ltd. Fully human antibodies against ox40, method for preparing the same, and use thereof
JP7346576B2 (ja) * 2018-12-25 2023-09-19 ハンクス バイオファーマシューティクス,インコーポレイテッド 抗ox40モノクローナル抗体とその応用
CN110172090B (zh) * 2019-06-03 2020-04-03 中山标佳生物科技有限公司 Cd134单克隆抗体及其制备方法和癌症治疗中的应用
WO2021098851A1 (en) * 2019-11-20 2021-05-27 Eucure (Beijing) Biopharma Co., Ltd Anti-ctla4/ox40 bispecific antibodies and uses thereof
IL293471A (en) 2019-12-17 2022-08-01 Amgen Inc Dual interleukin-2 / tnf receptor agonist for use in medicine
CN113045654A (zh) * 2019-12-27 2021-06-29 南开大学 抗ox40抗体及其用途
CN111303285B (zh) * 2019-12-27 2023-06-02 百力司康生物医药(杭州)有限公司 靶向ox40的抗体及其制备方法和应用
CN113429483A (zh) * 2020-03-23 2021-09-24 百奥泰生物制药股份有限公司 一种免疫细胞激活剂的开发及应用
CN115461367A (zh) * 2020-04-17 2022-12-09 和记黄埔医药(上海)有限公司 抗ox40抗体及其用途
US20230295324A1 (en) * 2020-06-30 2023-09-21 Harbour Biomed (Shanghai) Co., Ltd Ox40-targeted antibody, and preparation method therefor and application thereof
CN121270701A (zh) * 2020-07-23 2026-01-06 达因疗法公司 肌肉靶向复合物及其用途
CN111704671B (zh) * 2020-08-19 2020-11-24 广东赛尔生物科技有限公司 Ox40抗体及其在治疗癌症中的应用
CN112442121A (zh) * 2020-08-20 2021-03-05 山东兴瑞生物科技有限公司 Ox40抗体、其编码基因、及抗体的制备方法和在增强人体免疫功能中的应用
CN114106173A (zh) * 2020-08-26 2022-03-01 上海泰槿生物技术有限公司 抗ox40抗体、其药物组合物及应用
CN111763258B (zh) * 2020-09-01 2020-12-29 北京百奥赛图基因生物技术有限公司 抗ox40抗体及其用途
CN114515335A (zh) * 2020-11-19 2022-05-20 百奥泰生物制药股份有限公司 抗ox40抗体在治疗肿瘤或癌症中的应用
JP2024508207A (ja) 2020-12-02 2024-02-26 ブイアイビー ブイゼットダブリュ がんに対する組み合わせ治療におけるltbrアゴニスト
CN115260312B (zh) * 2021-04-30 2025-02-14 保诺科技(北京)有限公司 结合ox40的抗体或抗原结合片段
CN118121694A (zh) * 2022-12-01 2024-06-04 北京东方百泰生物科技股份有限公司 一种抗Siglec-15单克隆抗体的注射制剂

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4716111A (en) 1982-08-11 1987-12-29 Trustees Of Boston University Process for producing human antibodies
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
DK0710719T3 (da) 1990-01-12 2007-07-09 Amgen Fremont Inc Frembringelse af xenogene antistoffer
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DE69127627T2 (de) 1990-08-29 1998-02-19 Genpharm Int Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
ATE408012T1 (de) 1991-12-02 2008-09-15 Medical Res Council Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
EP1978033A3 (en) 1995-04-27 2008-12-24 Amgen Fremont Inc. Human antibodies derived from immunized xenomice
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5834597A (en) 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
ATE549918T1 (de) 1996-12-03 2012-04-15 Amgen Fremont Inc Menschliche antikörper, die ausdrücklich menschliches tnf alpha binden
EP0970126B1 (en) 1997-04-14 2001-04-18 Micromet AG Novel method for the production of antihuman antigen receptors and uses thereof
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
EP1997893A1 (en) 1998-02-24 2008-12-03 Sisters of Providence in Oregon Compositions containing an OX-40 receptor binding agent or a nucleic acid encoding the same and methods for enhancing antigen-specific immune response
US6312700B1 (en) 1998-02-24 2001-11-06 Andrew D. Weinberg Method for enhancing an antigen specific immune response with OX-40L
US6632926B1 (en) 1998-11-18 2003-10-14 Genentech, Inc. Antibody variants
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
WO2003106498A2 (en) 2002-06-13 2003-12-24 Crucell Holland, B.V. Agonistic binding molecules to the human ox40 receptor
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
WO2005123780A2 (en) 2004-04-09 2005-12-29 Protein Design Labs, Inc. Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
TWI380996B (zh) 2004-09-17 2013-01-01 Hoffmann La Roche 抗ox40l抗體
CA2587766A1 (en) 2004-11-10 2007-03-01 Macrogenics, Inc. Engineering fc antibody regions to confer effector function
TWI461436B (zh) * 2005-11-25 2014-11-21 Kyowa Hakko Kirin Co Ltd 人類cd134(ox40)之人類單株抗體及其製造及使用方法
US20080286286A1 (en) 2006-01-13 2008-11-20 Board Of Regents, The University Of Texas System Methods to Treat Disease States by Influencing the Signaling of Ox-40-Receptors and High Throughput Screening Methods for Identifying Substances Therefor
AU2008338591B8 (en) 2007-12-14 2014-02-20 Bristol-Myers Squibb Company Binding molecules to the human OX40 receptor
US9006399B2 (en) * 2010-08-23 2015-04-14 Board Of Regents, The University Of Texas System Anti-OX40 antibodies and methods of using the same
CN103946238B (zh) * 2011-08-23 2016-10-12 德克萨斯州立大学董事会 抗ox40抗体及使用其的方法
MX368665B (es) 2013-03-15 2019-10-10 Abbvie Biotherapeutics Inc Variantes de fc.
KR20160006168A (ko) * 2013-03-18 2016-01-18 바이오서오엑스 프로덕스 비.브이. 인간화 항-cd134(ox40) 항체 및 이의 용도
MX2016012779A (es) 2014-03-31 2017-04-27 Genentech Inc Terapia de combinacion con agentes antiangiogénesis y agonistas de unión a ox40.
TW201619200A (zh) 2014-10-10 2016-06-01 麥迪紐有限責任公司 人類化抗-ox40抗體及其用途
AU2015343339A1 (en) * 2014-11-03 2017-06-15 Genentech, Inc. Methods and biomarkers for predicting efficacy and evaluation of an OX40 agonist treatment
CN115109158A (zh) * 2015-05-07 2022-09-27 阿吉纳斯公司 抗ox40抗体及其使用方法
EP3298045A1 (en) * 2015-05-21 2018-03-28 Alligator Bioscience AB Novel polypeptides
US20160347848A1 (en) * 2015-05-28 2016-12-01 Medimmune Limited Therapeutic combinations and methods for treating neoplasia
MA43389A (fr) 2015-12-02 2021-05-12 Agenus Inc Anticorps anti-ox40 et leurs procédés d'utilisation
EP3504242B1 (en) * 2016-12-15 2020-06-24 AbbVie Biotherapeutics Inc. Anti-ox40 antibodies and their uses

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