CA3045940A1 - Anti-ox40 antibodies and their uses - Google Patents
Anti-ox40 antibodies and their uses Download PDFInfo
- Publication number
- CA3045940A1 CA3045940A1 CA3045940A CA3045940A CA3045940A1 CA 3045940 A1 CA3045940 A1 CA 3045940A1 CA 3045940 A CA3045940 A CA 3045940A CA 3045940 A CA3045940 A CA 3045940A CA 3045940 A1 CA3045940 A1 CA 3045940A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- antibody
- amino acid
- acid sequence
- chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662434761P | 2016-12-15 | 2016-12-15 | |
| US62/434,761 | 2016-12-15 | ||
| PCT/US2017/066680 WO2018112346A1 (en) | 2016-12-15 | 2017-12-15 | Anti-ox40 antibodies and their uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3045940A1 true CA3045940A1 (en) | 2018-06-21 |
Family
ID=60937946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3045940A Abandoned CA3045940A1 (en) | 2016-12-15 | 2017-12-15 | Anti-ox40 antibodies and their uses |
Country Status (37)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY37523A (es) * | 2016-12-15 | 2018-07-31 | Abbvie Biotherapeutics Inc | Anticuerpos anti-ox40 y sus usos |
| CA3066007A1 (en) * | 2017-06-09 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy with icos agonist and ox40 agonist to treat cancer |
| US11242398B2 (en) * | 2017-08-01 | 2022-02-08 | Remd Biotherapeutics, Inc. | Anti-OX40 antibodies and methods of activating OX40 |
| CN110790837A (zh) * | 2018-08-02 | 2020-02-14 | 上海君实生物医药科技股份有限公司 | 抗btla抗体 |
| WO2020119789A1 (en) * | 2018-12-14 | 2020-06-18 | Wuxi Biologics (Shanghai) Co., Ltd. | Fully human antibodies against ox40, method for preparing the same, and use thereof |
| WO2020132857A1 (zh) * | 2018-12-25 | 2020-07-02 | 杭州翰思生物医药有限公司 | 抗ox40的单克隆抗体及其应用 |
| CN110172090B (zh) * | 2019-06-03 | 2020-04-03 | 中山标佳生物科技有限公司 | Cd134单克隆抗体及其制备方法和癌症治疗中的应用 |
| WO2021098851A1 (en) * | 2019-11-20 | 2021-05-27 | Eucure (Beijing) Biopharma Co., Ltd | Anti-ctla4/ox40 bispecific antibodies and uses thereof |
| PE20221506A1 (es) | 2019-12-17 | 2022-10-04 | Amgen Inc | Agonista doble de interleucina-2/receptor de tnf para uso en terapia |
| CN111303285B (zh) * | 2019-12-27 | 2023-06-02 | 百力司康生物医药(杭州)有限公司 | 靶向ox40的抗体及其制备方法和应用 |
| CN113045654A (zh) * | 2019-12-27 | 2021-06-29 | 南开大学 | 抗ox40抗体及其用途 |
| CN113429483A (zh) * | 2020-03-23 | 2021-09-24 | 百奥泰生物制药股份有限公司 | 一种免疫细胞激活剂的开发及应用 |
| EP4136116A4 (en) * | 2020-04-17 | 2024-06-19 | Hutchison Medipharma Limited | ANTI-OX40 ANTIBODIES AND USES THEREOF |
| CN115461371B (zh) * | 2020-06-30 | 2026-02-13 | 和铂医药(上海)有限责任公司 | 靶向ox40的抗体及其制备方法和应用 |
| AU2021313058A1 (en) * | 2020-07-23 | 2023-03-30 | Dyne Therapeutics, Inc. | Muscle-targeting complexes and uses thereof |
| CN111704671B (zh) * | 2020-08-19 | 2020-11-24 | 广东赛尔生物科技有限公司 | Ox40抗体及其在治疗癌症中的应用 |
| CN112442121A (zh) * | 2020-08-20 | 2021-03-05 | 山东兴瑞生物科技有限公司 | Ox40抗体、其编码基因、及抗体的制备方法和在增强人体免疫功能中的应用 |
| CN114106173A (zh) * | 2020-08-26 | 2022-03-01 | 上海泰槿生物技术有限公司 | 抗ox40抗体、其药物组合物及应用 |
| CN111763258B (zh) * | 2020-09-01 | 2020-12-29 | 北京百奥赛图基因生物技术有限公司 | 抗ox40抗体及其用途 |
| CN114515335A (zh) * | 2020-11-19 | 2022-05-20 | 百奥泰生物制药股份有限公司 | 抗ox40抗体在治疗肿瘤或癌症中的应用 |
| JP2024508207A (ja) | 2020-12-02 | 2024-02-26 | ブイアイビー ブイゼットダブリュ | がんに対する組み合わせ治療におけるｌｔｂｒアゴニスト |
| AU2022214914A1 (en) * | 2021-01-28 | 2023-08-17 | Astria Therapeutics, Inc. | Plasma kallikrein antibodies and uses thereof |
| CN117015394A (zh) * | 2021-03-12 | 2023-11-07 | 博际生物医药科技(杭州)有限公司 | 结合人TGFβ和PD-L1的双功能分子及其应用 |
| CN115260312B (zh) * | 2021-04-30 | 2025-02-14 | 保诺科技（北京）有限公司 | 结合ox40的抗体或抗原结合片段 |
| EP4366774A4 (en) * | 2021-07-09 | 2025-11-19 | Dyne Therapeutics Inc | MUSCLE TARGETTING COMPLEXES AND THEIR USES FOR MODULATING GENES ASSOCIATED WITH MUSCLE HEALTH |
| CN118121694B (zh) * | 2022-12-01 | 2026-03-27 | 北京东方百泰生物科技股份有限公司 | 一种抗Siglec-15单克隆抗体的注射制剂 |
| CN122080196B (zh) * | 2026-04-23 | 2026-07-24 | 北京溯本源和生物科技有限公司 | 一种抗禽流感病毒h7亚型血凝素蛋白的单克隆抗体及应用 |
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| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
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| LT2609118T (lt) * | 2010-08-23 | 2017-04-25 | Board Of Regents, The University Of Texas System | Anti-ox40 antikūnai ir jų panaudojimo būdai |
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-
2017
- 2017-12-15 UY UY0001037523A patent/UY37523A/es not_active Application Discontinuation
- 2017-12-15 CA CA3045940A patent/CA3045940A1/en not_active Abandoned
- 2017-12-15 AU AU2017377036A patent/AU2017377036B2/en not_active Ceased
- 2017-12-15 US US15/843,281 patent/US10556962B2/en active Active
- 2017-12-15 SG SG10201914126RA patent/SG10201914126RA/en unknown
- 2017-12-15 WO PCT/US2017/066680 patent/WO2018112346A1/en not_active Ceased
- 2017-12-15 EP EP17826089.9A patent/EP3504242B1/en active Active
- 2017-12-15 MA MA053184A patent/MA53184A/fr unknown
- 2017-12-15 TW TW106144235A patent/TWI734879B/zh not_active IP Right Cessation
- 2017-12-15 RU RU2019121895A patent/RU2753493C2/ru active
- 2017-12-15 JP JP2019531934A patent/JP6772385B2/ja not_active Expired - Fee Related
- 2017-12-15 PE PE2019001249A patent/PE20191403A1/es unknown
- 2017-12-15 EP EP20173858.0A patent/EP3725809A1/en not_active Withdrawn
- 2017-12-15 CN CN201780086610.XA patent/CN110573527A/zh active Pending
- 2017-12-15 RS RS20200923A patent/RS60664B1/sr unknown
- 2017-12-15 KR KR1020217041290A patent/KR20210157471A/ko not_active Withdrawn
- 2017-12-15 KR KR1020197020437A patent/KR102341926B1/ko not_active Expired - Fee Related
- 2017-12-15 UA UAA201907981A patent/UA125041C2/uk unknown
- 2017-12-15 AR ARP170103527A patent/AR110526A1/es unknown
- 2017-12-15 BR BR112019012328-8A patent/BR112019012328A2/pt not_active Application Discontinuation
- 2017-12-15 LT LTEP17826089.9T patent/LT3504242T/lt unknown
- 2017-12-15 PT PT178260899T patent/PT3504242T/pt unknown
- 2017-12-15 MY MYPI2019003403A patent/MY198059A/en unknown
- 2017-12-15 PL PL17826089T patent/PL3504242T3/pl unknown
- 2017-12-15 CR CR20190330A patent/CR20190330A/es unknown
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