JP2015519076A5 - - Google Patents
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- JP2015519076A5 JP2015519076A5 JP2015517239A JP2015517239A JP2015519076A5 JP 2015519076 A5 JP2015519076 A5 JP 2015519076A5 JP 2015517239 A JP2015517239 A JP 2015517239A JP 2015517239 A JP2015517239 A JP 2015517239A JP 2015519076 A5 JP2015519076 A5 JP 2015519076A5
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- Prior art keywords
- human
- mouse
- gene
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 241000699666 Mus <mouse, genus> Species 0.000 claims description 82
- 108090000623 proteins and genes Proteins 0.000 claims description 69
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 15
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 15
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 108060003951 Immunoglobulin Proteins 0.000 claims description 7
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims description 7
- 241000699670 Mus sp. Species 0.000 claims description 7
- 102000018358 immunoglobulin Human genes 0.000 claims description 7
- 210000004602 germ cell Anatomy 0.000 claims description 4
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims description 3
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims description 3
- 101000746783 Homo sapiens Cytochrome b-c1 complex subunit 6, mitochondrial Proteins 0.000 claims description 2
- 238000012217 deletion Methods 0.000 claims description 2
- 230000037430 deletion Effects 0.000 claims description 2
- 102000048638 human UQCRH Human genes 0.000 claims description 2
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims 1
- 108700026220 vif Genes Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 description 18
- 239000000427 antigen Substances 0.000 description 8
- 108091007433 antigens Proteins 0.000 description 8
- 102000036639 antigens Human genes 0.000 description 8
- 230000004048 modification Effects 0.000 description 7
- 238000012986 modification Methods 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 description 5
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 150000007523 nucleic acids Chemical group 0.000 description 4
- 101150117115 V gene Proteins 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 2
- 108700005091 Immunoglobulin Genes Proteins 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 101150008942 J gene Proteins 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261658466P | 2012-06-12 | 2012-06-12 | |
| US61/658,466 | 2012-06-12 | ||
| US201261663131P | 2012-06-22 | 2012-06-22 | |
| US61/663,131 | 2012-06-22 | ||
| PCT/US2013/029624 WO2013187953A1 (en) | 2012-06-12 | 2013-03-07 | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017230304A Division JP6697430B2 (ja) | 2012-06-12 | 2017-11-30 | 限定された免疫グロブリン重鎖遺伝子座を有するヒト化非ヒト動物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015519076A JP2015519076A (ja) | 2015-07-09 |
| JP2015519076A5 true JP2015519076A5 (enExample) | 2016-04-07 |
Family
ID=47892070
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517239A Withdrawn JP2015519076A (ja) | 2012-06-12 | 2013-03-07 | 限定された免疫グロブリン重鎖遺伝子座を有するヒト化非ヒト動物 |
| JP2017230304A Active JP6697430B2 (ja) | 2012-06-12 | 2017-11-30 | 限定された免疫グロブリン重鎖遺伝子座を有するヒト化非ヒト動物 |
| JP2020077376A Active JP7106596B2 (ja) | 2012-06-12 | 2020-04-24 | 限定された免疫グロブリン重鎖遺伝子座を有するヒト化非ヒト動物 |
| JP2022071670A Pending JP2022090103A (ja) | 2012-06-12 | 2022-04-25 | 限定された免疫グロブリン重鎖遺伝子座を有するヒト化非ヒト動物 |
| JP2023147111A Pending JP2023165683A (ja) | 2012-06-12 | 2023-09-11 | 限定された免疫グロブリン重鎖遺伝子座を有するヒト化非ヒト動物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017230304A Active JP6697430B2 (ja) | 2012-06-12 | 2017-11-30 | 限定された免疫グロブリン重鎖遺伝子座を有するヒト化非ヒト動物 |
| JP2020077376A Active JP7106596B2 (ja) | 2012-06-12 | 2020-04-24 | 限定された免疫グロブリン重鎖遺伝子座を有するヒト化非ヒト動物 |
| JP2022071670A Pending JP2022090103A (ja) | 2012-06-12 | 2022-04-25 | 限定された免疫グロブリン重鎖遺伝子座を有するヒト化非ヒト動物 |
| JP2023147111A Pending JP2023165683A (ja) | 2012-06-12 | 2023-09-11 | 限定された免疫グロブリン重鎖遺伝子座を有するヒト化非ヒト動物 |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US10238093B2 (enExample) |
| EP (3) | EP2858487B1 (enExample) |
| JP (5) | JP2015519076A (enExample) |
| KR (8) | KR102266274B1 (enExample) |
| CN (1) | CN104540383B (enExample) |
| AU (4) | AU2013204582B2 (enExample) |
| BR (1) | BR112014030852B1 (enExample) |
| CA (1) | CA2876172C (enExample) |
| CY (2) | CY1122482T1 (enExample) |
| DK (2) | DK3597037T3 (enExample) |
| ES (2) | ES2874515T3 (enExample) |
| HR (2) | HRP20200093T1 (enExample) |
| HU (2) | HUE055617T2 (enExample) |
| IL (1) | IL235892A (enExample) |
| LT (2) | LT3597037T (enExample) |
| ME (1) | ME03551B (enExample) |
| MX (3) | MX379274B (enExample) |
| NZ (2) | NZ703689A (enExample) |
| PL (2) | PL3597037T3 (enExample) |
| PT (2) | PT3597037T (enExample) |
| RS (2) | RS59890B1 (enExample) |
| RU (1) | RU2656155C2 (enExample) |
| SG (3) | SG11201407789RA (enExample) |
| SI (2) | SI2858487T1 (enExample) |
| SM (2) | SMT202100426T1 (enExample) |
| WO (1) | WO2013187953A1 (enExample) |
Families Citing this family (37)
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| EP3028565B1 (en) | 2009-07-08 | 2017-09-27 | Kymab Limited | Animal models and therapeutic molecules |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| WO2011072117A1 (en) | 2009-12-09 | 2011-06-16 | The Procter & Gamble Company | Fabric and home care products |
| US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| RU2580017C2 (ru) | 2010-07-26 | 2016-04-10 | Трианни, Инк. | Трансгенные животные и способы применения |
| DK2813573T1 (da) | 2011-02-25 | 2015-01-12 | Regeneron Pharma | ADAM6 mus |
| HUE068728T2 (hu) | 2011-08-05 | 2025-01-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
| EP2757875B2 (en) | 2011-09-19 | 2023-03-22 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| PL3216871T3 (pl) * | 2011-10-17 | 2022-03-21 | Regeneron Pharmaceuticals, Inc. | Ograniczony łańcuch ciężki immonoglobuliny pochodzącej od myszy |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| PL2809150T3 (pl) * | 2012-02-01 | 2020-04-30 | Regeneron Pharmaceuticals, Inc. | Humanizowane myszy wykazujące ekspresję łańcuchów ciężkich zawierających domeny VL |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| EP2858487B1 (en) | 2012-06-12 | 2019-10-23 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
| RS57582B1 (sr) | 2013-02-20 | 2018-11-30 | Regeneron Pharma | Nehumane životinje sa modifikovanim sekvencama imunoglobulinskog teškog lanca |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| US20140331344A1 (en) * | 2013-05-03 | 2014-11-06 | Kymab Ltd. | Transgenic Animals |
| WO2015049517A2 (en) | 2013-10-01 | 2015-04-09 | Kymab Limited | Animal models and therapeutic molecules |
| EP3096609B1 (en) * | 2014-01-24 | 2021-09-22 | Children's Medical Center Corporation | High-throughput mouse model for optimizing antibody affinities |
| US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| WO2017095939A1 (en) | 2015-12-03 | 2017-06-08 | Trianni, Inc. | Enhanced immunoglobulin diversity |
| WO2017136734A1 (en) | 2016-02-04 | 2017-08-10 | Trianni, Inc. | Enhanced production of immunoglobulins |
| WO2017201476A1 (en) | 2016-05-20 | 2017-11-23 | Regeneron Pharmaceuticals, Inc. | Methods for breaking immunological tolerance using multiple guide rnas |
| PL3720279T3 (pl) * | 2017-12-05 | 2023-01-16 | Regeneron Pharmaceuticals, Inc. | Myszy posiadające zmodyfikowany sposobami inżynierii łańcuch lekki lambda immunoglobuliny oraz ich zastosowania |
| CN108486125B (zh) * | 2018-03-27 | 2024-01-05 | 重庆金迈博生物科技有限公司 | 一种核酸分子及其在制备人源单域抗体中的应用 |
| IL318469A (en) * | 2018-06-14 | 2025-03-01 | Regeneron Pharma | Non-human animals capable of reorganizing transgenic DH-DH, and their uses |
| AU2020226445B2 (en) * | 2019-02-18 | 2025-05-29 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with humanized immunoglobulin locus |
| AU2021283564B2 (en) | 2020-06-02 | 2025-05-29 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with common light chain immunoglobulin locus |
| EP4211155A1 (en) | 2020-09-11 | 2023-07-19 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| EP4262373A1 (en) | 2020-12-16 | 2023-10-25 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| JP7758739B2 (ja) * | 2020-12-23 | 2025-10-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | アンカー改変型抗体をコードする核酸およびその使用 |
| TWI897189B (zh) * | 2023-01-18 | 2025-09-11 | 美商基利科學股份有限公司 | 具有經改變重鏈基因座之嵌合基因轉殖免疫球蛋白小鼠及其製造及使用方法 |
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| DK2813573T1 (da) | 2011-02-25 | 2015-01-12 | Regeneron Pharma | ADAM6 mus |
| HUE068728T2 (hu) * | 2011-08-05 | 2025-01-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
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| JP2014531452A (ja) | 2011-09-19 | 2014-11-27 | カイマブ・リミテッド | 動物、レパートリーおよび方法 |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| PL3216871T3 (pl) | 2011-10-17 | 2022-03-21 | Regeneron Pharmaceuticals, Inc. | Ograniczony łańcuch ciężki immonoglobuliny pochodzącej od myszy |
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| PL2809150T3 (pl) | 2012-02-01 | 2020-04-30 | Regeneron Pharmaceuticals, Inc. | Humanizowane myszy wykazujące ekspresję łańcuchów ciężkich zawierających domeny VL |
| EP3348140B1 (en) | 2012-03-16 | 2020-12-30 | Regeneron Pharmaceuticals, Inc. | Histidine engineered light chain antibodies and genetically modified rodents for generating the same |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
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| EP2858487B1 (en) | 2012-06-12 | 2019-10-23 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
| RS57582B1 (sr) | 2013-02-20 | 2018-11-30 | Regeneron Pharma | Nehumane životinje sa modifikovanim sekvencama imunoglobulinskog teškog lanca |
| PT3501272T (pt) | 2013-03-13 | 2023-03-29 | Regeneron Pharma | Murganhos que expressam um repertório limitado de cadeia leve de imunoglobulina |
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