JP2011182801A5 - - Google Patents
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- Publication number
- JP2011182801A5 JP2011182801A5 JP2011131898A JP2011131898A JP2011182801A5 JP 2011182801 A5 JP2011182801 A5 JP 2011182801A5 JP 2011131898 A JP2011131898 A JP 2011131898A JP 2011131898 A JP2011131898 A JP 2011131898A JP 2011182801 A5 JP2011182801 A5 JP 2011182801A5
- Authority
- JP
- Japan
- Prior art keywords
- gene segment
- humanized
- locus
- gene
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000009261 transgenic effect Effects 0.000 claims 18
- 239000002773 nucleotide Substances 0.000 claims 15
- 125000003729 nucleotide group Chemical group 0.000 claims 15
- 108700005091 Immunoglobulin Genes Proteins 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 150000007523 nucleic acids Chemical class 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 108060003951 Immunoglobulin Proteins 0.000 claims 10
- 102000018358 immunoglobulin Human genes 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 6
- 101150117115 V gene Proteins 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 101150008942 J gene Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 229940072221 immunoglobulins Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000008707 rearrangement Effects 0.000 claims 2
- 241000272525 Anas platyrhynchos Species 0.000 claims 1
- 241000272814 Anser sp. Species 0.000 claims 1
- 241000283690 Bos taurus Species 0.000 claims 1
- 241000283707 Capra Species 0.000 claims 1
- 101150097493 D gene Proteins 0.000 claims 1
- 241000283074 Equus asinus Species 0.000 claims 1
- 241000283073 Equus caballus Species 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 241000282898 Sus scrofa Species 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 230000016784 immunoglobulin production Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000007246 mechanism Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000008844 regulatory mechanism Effects 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48773303P | 2003-07-15 | 2003-07-15 | |
| US60/487,733 | 2003-07-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520411A Division JP2007537704A (ja) | 2003-07-15 | 2004-07-15 | ヒト化免疫グロブリン遺伝子座 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011182801A JP2011182801A (ja) | 2011-09-22 |
| JP2011182801A5 true JP2011182801A5 (enExample) | 2012-07-19 |
| JP6017763B2 JP6017763B2 (ja) | 2016-11-02 |
Family
ID=34079388
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520411A Withdrawn JP2007537704A (ja) | 2003-07-15 | 2004-07-15 | ヒト化免疫グロブリン遺伝子座 |
| JP2011131898A Expired - Lifetime JP6017763B2 (ja) | 2003-07-15 | 2011-06-14 | ヒト化免疫グロブリン遺伝子座 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520411A Withdrawn JP2007537704A (ja) | 2003-07-15 | 2004-07-15 | ヒト化免疫グロブリン遺伝子座 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US7585668B2 (enExample) |
| EP (1) | EP1644417B1 (enExample) |
| JP (2) | JP2007537704A (enExample) |
| CN (2) | CN103205436B (enExample) |
| AU (1) | AU2004257292A1 (enExample) |
| CA (1) | CA2532117C (enExample) |
| ES (1) | ES2473596T3 (enExample) |
| IL (1) | IL172885A0 (enExample) |
| MX (1) | MXPA06000562A (enExample) |
| WO (1) | WO2005007696A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| MXPA06000562A (es) * | 2003-07-15 | 2006-03-30 | Therapeutic Human Polyclonals | Loci de inmunoglobulina humanizada. |
| WO2007140457A2 (en) * | 2006-05-31 | 2007-12-06 | Genzyme Corporation | Methods of using anti-thymocyte globulin and related agents |
| WO2008027986A2 (en) * | 2006-09-01 | 2008-03-06 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| US20090053210A1 (en) | 2006-09-01 | 2009-02-26 | Roland Buelow | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| EP2602323B1 (en) * | 2007-06-01 | 2018-02-28 | Open Monoclonal Technology, Inc. | Compositions and methods for inhibiting endogenous immunoglobin genes and producing transgenic human idiotype antibodies |
| US9693539B2 (en) * | 2007-08-10 | 2017-07-04 | E. R. Squibb & Sons, L.L.C. | HCO32 and HCO27 and related examples |
| KR101563017B1 (ko) * | 2007-08-14 | 2015-10-23 | 오리겐 테라퓨틱스 인코포레이티드 | 불활성화된 내인성 유전자좌를 갖는 트랜스제닉 닭 |
| EP2108696A1 (en) * | 2008-04-10 | 2009-10-14 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Cis-acting diversification activator and method for selective diversification of nucleic acids |
| CN112690250B (zh) * | 2008-12-18 | 2024-03-08 | 伊拉兹马斯大学鹿特丹医学中心 | 表达人源化抗体的非人转基因动物及其用途 |
| EP3028565B1 (en) * | 2009-07-08 | 2017-09-27 | Kymab Limited | Animal models and therapeutic molecules |
| EP2464220A4 (en) * | 2009-08-13 | 2014-05-07 | Crystal Bioscience Inc | Transgenic animal for the production of antibodies with minimal complementarity-determining regions |
| US8865462B2 (en) * | 2010-01-20 | 2014-10-21 | Crystal Bioscience Inc. | Sustained culture of avian gonocytes |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| SMT201900372T1 (it) | 2010-02-08 | 2019-09-09 | Regeneron Pharma | Topo con catena leggera comune |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| KR102004106B1 (ko) | 2010-03-31 | 2019-07-25 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작 |
| SI2480676T1 (sl) | 2010-06-22 | 2016-10-28 | Regeneron Pharmaceuticals, Inc. | Hibridna mišja lahka veriga |
| RU2612903C2 (ru) | 2010-08-02 | 2017-03-13 | Ридженерон Фармасьютикалз, Инк. | Мыши, у которых вырабатываются связывающие белки, содержащие vl-домены |
| CN102250239B (zh) * | 2011-06-13 | 2013-04-17 | 中国农业科学院哈尔滨兽医研究所 | 一种与兔出血症病毒vp60蛋白相结合的蛋白及其应用 |
| HUE068728T2 (hu) | 2011-08-05 | 2025-01-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
| EP2757875B2 (en) * | 2011-09-19 | 2023-03-22 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| PL3216871T3 (pl) | 2011-10-17 | 2022-03-21 | Regeneron Pharmaceuticals, Inc. | Ograniczony łańcuch ciężki immonoglobuliny pochodzącej od myszy |
| MX378871B (es) | 2011-12-20 | 2025-03-10 | Regeneron Pharma | Ratones con cadena ligera humanizada. |
| EP2794662A1 (en) | 2011-12-22 | 2014-10-29 | F.Hoffmann-La Roche Ag | Full length antibody display system for eukaryotic cells and its use |
| PL2809150T3 (pl) * | 2012-02-01 | 2020-04-30 | Regeneron Pharmaceuticals, Inc. | Humanizowane myszy wykazujące ekspresję łańcuchów ciężkich zawierających domeny VL |
| KR102213535B1 (ko) | 2012-03-16 | 2021-02-08 | 리제너론 파마슈티칼스 인코포레이티드 | pH-민감성 면역글로불린 서열을 발현하는 비-사람 동물 |
| EP3348140B1 (en) | 2012-03-16 | 2020-12-30 | Regeneron Pharmaceuticals, Inc. | Histidine engineered light chain antibodies and genetically modified rodents for generating the same |
| EP2858487B1 (en) | 2012-06-12 | 2019-10-23 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
| WO2014022853A1 (en) * | 2012-08-03 | 2014-02-06 | Sanford Applied Biosciences, L.L.C. | Complex chromosome engineering for production of human antibodies in transgenic animals |
| RS57582B1 (sr) | 2013-02-20 | 2018-11-30 | Regeneron Pharma | Nehumane životinje sa modifikovanim sekvencama imunoglobulinskog teškog lanca |
| RU2015143108A (ru) * | 2013-03-13 | 2017-04-20 | Регенерон Фарматютикалз, Инк. | Мышь с общей легкой цепью |
| PT3501272T (pt) * | 2013-03-13 | 2023-03-29 | Regeneron Pharma | Murganhos que expressam um repertório limitado de cadeia leve de imunoglobulina |
| WO2015103999A1 (en) * | 2014-01-10 | 2015-07-16 | Hung Alfur Fu-Hsin | Transgenic animals capable of producing humanized ige at much higher levels than mouse ige |
| WO2015143406A2 (en) | 2014-03-21 | 2015-09-24 | Regeneron Pharmaceuticals, Inc. | Vl antigen binding proteins exhibiting distinct binding characteristics |
| RU2016141307A (ru) | 2014-03-21 | 2018-04-24 | Регенерон Фармасьютикалз, Инк. | Отличные от человека животные, которые вырабатывают однодоменные связывающие белки |
| DK3138903T3 (da) * | 2014-05-02 | 2022-04-19 | Chiome Bioscience Inc | Celler til produktion af humant antistof |
| US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| CN113862300A (zh) * | 2015-10-29 | 2021-12-31 | 豪夫迈·罗氏有限公司 | 具有共同轻链的转基因兔 |
| MA53935A (fr) * | 2016-11-04 | 2021-12-22 | Regeneron Pharma | Animaux non humains ayant un locus à chaîne légère lambda d'immunoglobuline modifiée |
| CN110149809B (zh) | 2016-12-05 | 2023-04-14 | 皇家飞利浦有限公司 | 无线功率传输系统中的异物检测 |
| SG10202109874VA (en) | 2017-01-19 | 2021-10-28 | Open Monoclonal Tech Inc | Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci |
| JP2021508471A (ja) | 2017-12-29 | 2021-03-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 抗ｖｅｇｆ抗体のｖｅｇｆ受容体遮断選択性を改善する方法 |
| EP3768079A4 (en) * | 2018-03-21 | 2021-12-08 | Crystal Bioscience Inc. | TRANSGENIC CHICKEN THAT PRODUCES HUMAN ANTIBODIES |
| JP7354306B2 (ja) | 2019-06-27 | 2023-10-02 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 新規ｉｃｏｓ抗体及びそれらを含む腫瘍標的化抗原結合分子 |
| AR119382A1 (es) | 2019-07-12 | 2021-12-15 | Hoffmann La Roche | Anticuerpos de pre-direccionamiento y métodos de uso |
| AR119393A1 (es) | 2019-07-15 | 2021-12-15 | Hoffmann La Roche | Anticuerpos que se unen a nkg2d |
| CN110540996B (zh) * | 2019-08-29 | 2022-01-28 | 华中农业大学 | 一种克氏原螯虾i型溶菌酶gLysi2基因、其编码的gLysi2蛋白及其应用 |
| WO2021127068A1 (en) * | 2019-12-18 | 2021-06-24 | Bristol-Myers Squibb Company | Bcr transgenic mice with a common leader sequence |
| CR20240246A (es) | 2021-12-20 | 2024-07-19 | Hoffmann La Roche | Anticuerpos agonistas anti-ltbr y anticuerpos biespecificos que los comprenden |
| CN114854901B (zh) * | 2022-06-22 | 2025-11-07 | 华南农业大学 | 与苦瓜全雌性状共分离的分子标记、引物及其应用 |
| WO2024261013A1 (en) | 2023-06-21 | 2024-12-26 | F. Hoffmann-La Roche Ag | Combination therapy with fap-targeted lymphotoxin beta receptor agonists |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5411881A (en) | 1990-07-10 | 1995-05-02 | Nkk Corporation | Chicken-specific immunoglobulin G-producing hybridoma |
| KR100272077B1 (ko) * | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
| EP0583980A1 (en) | 1992-08-20 | 1994-02-23 | Eli Lilly And Company | Method for generating monoclonal antibodies from rabbits |
| AU7326796A (en) | 1995-10-30 | 1997-05-22 | Spectral Diagnostics Inc. | Stable chicken b-cell line and method of use thereof |
| JP5694623B2 (ja) | 1999-02-05 | 2015-04-01 | セラピューティック ヒューマン ポリクローナルズ， インコーポレイテッド | 遺伝子操作した動物から得られるヒトポリクローナル抗体 |
| CA2375441A1 (en) | 1999-06-04 | 2000-12-14 | Tranxenogen, Inc. | Methods for manipulating the avian genome |
| AU7491800A (en) | 1999-09-15 | 2001-04-17 | Therapeutic Human Polyclonals, Inc. | Immunotherapy with substantially human polyclonal antibody preparations purifiedfrom genetically engineered birds |
| CA2634294A1 (en) * | 2000-08-03 | 2002-02-14 | Therapeutic Human Polyclonals, Inc. | Production of humanized antibodies in transgenic animals |
| EP1539785B1 (en) | 2002-06-26 | 2009-05-06 | Transgenrx, Inc. | Gene regulation in transgenic animals using a transposon-based vector |
| MXPA06000562A (es) * | 2003-07-15 | 2006-03-30 | Therapeutic Human Polyclonals | Loci de inmunoglobulina humanizada. |
| EP1782360A4 (en) | 2004-08-27 | 2009-03-18 | Medic4All Ag | METHOD AND SYSTEM FOR THE USE OF A MOBILE DEVICE AS A PORTABLE PERSONAL TERMINAL FOR MEDICAL INFORMATION |
| US20110077965A1 (en) | 2009-09-25 | 2011-03-31 | Cerner Innovation, Inc. | Processing event information of various sources |
| US20120306653A1 (en) | 2011-06-02 | 2012-12-06 | Nokia Siemens Networks Oy | Medical sensor |
| US20130021154A1 (en) | 2011-07-21 | 2013-01-24 | Solomon Clifford T | Medical parameters notification system |
-
2004
- 2004-07-15 MX MXPA06000562A patent/MXPA06000562A/es unknown
- 2004-07-15 CA CA2532117A patent/CA2532117C/en not_active Expired - Lifetime
- 2004-07-15 JP JP2006520411A patent/JP2007537704A/ja not_active Withdrawn
- 2004-07-15 ES ES04778633.0T patent/ES2473596T3/es not_active Expired - Lifetime
- 2004-07-15 CN CN201210390234.2A patent/CN103205436B/zh not_active Expired - Lifetime
- 2004-07-15 CN CNA2004800261928A patent/CN1852925A/zh active Pending
- 2004-07-15 US US10/893,483 patent/US7585668B2/en active Active
- 2004-07-15 AU AU2004257292A patent/AU2004257292A1/en not_active Abandoned
- 2004-07-15 WO PCT/US2004/023226 patent/WO2005007696A2/en not_active Ceased
- 2004-07-15 EP EP04778633.0A patent/EP1644417B1/en not_active Expired - Lifetime
-
2005
- 2005-12-29 IL IL172885A patent/IL172885A0/en unknown
-
2009
- 2009-07-29 US US12/511,188 patent/US8410333B2/en not_active Expired - Fee Related
-
2011
- 2011-06-14 JP JP2011131898A patent/JP6017763B2/ja not_active Expired - Lifetime
-
2013
- 2013-02-27 US US13/779,585 patent/US8652842B2/en not_active Ceased
-
2016
- 2016-02-09 US US15/019,852 patent/USRE47131E1/en not_active Expired - Lifetime
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