JP2011182801A5 - - Google Patents
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- Publication number
- JP2011182801A5 JP2011182801A5 JP2011131898A JP2011131898A JP2011182801A5 JP 2011182801 A5 JP2011182801 A5 JP 2011182801A5 JP 2011131898 A JP2011131898 A JP 2011131898A JP 2011131898 A JP2011131898 A JP 2011131898A JP 2011182801 A5 JP2011182801 A5 JP 2011182801A5
- Authority
- JP
- Japan
- Prior art keywords
- gene segment
- humanized
- locus
- gene
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48773303P | 2003-07-15 | 2003-07-15 | |
| US60/487,733 | 2003-07-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520411A Division JP2007537704A (ja) | 2003-07-15 | 2004-07-15 | ヒト化免疫グロブリン遺伝子座 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011182801A JP2011182801A (ja) | 2011-09-22 |
| JP2011182801A5 true JP2011182801A5 (enExample) | 2012-07-19 |
| JP6017763B2 JP6017763B2 (ja) | 2016-11-02 |
Family
ID=34079388
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520411A Withdrawn JP2007537704A (ja) | 2003-07-15 | 2004-07-15 | ヒト化免疫グロブリン遺伝子座 |
| JP2011131898A Expired - Lifetime JP6017763B2 (ja) | 2003-07-15 | 2011-06-14 | ヒト化免疫グロブリン遺伝子座 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520411A Withdrawn JP2007537704A (ja) | 2003-07-15 | 2004-07-15 | ヒト化免疫グロブリン遺伝子座 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US7585668B2 (enExample) |
| EP (1) | EP1644417B1 (enExample) |
| JP (2) | JP2007537704A (enExample) |
| CN (2) | CN1852925A (enExample) |
| AU (1) | AU2004257292A1 (enExample) |
| CA (1) | CA2532117C (enExample) |
| ES (1) | ES2473596T3 (enExample) |
| IL (1) | IL172885A0 (enExample) |
| MX (1) | MXPA06000562A (enExample) |
| WO (1) | WO2005007696A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| CN1852925A (zh) * | 2003-07-15 | 2006-10-25 | 人类多克隆治疗公司 | 人源化免疫球蛋白基因座 |
| EP2029729A2 (en) * | 2006-05-31 | 2009-03-04 | Genzyme Corporation | Methods of using anti-thymocyte globulin and related agents |
| SG174053A1 (en) * | 2006-09-01 | 2011-09-29 | Therapeutic Human Polyclonals Inc | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| US20090053210A1 (en) * | 2006-09-01 | 2009-02-26 | Roland Buelow | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| KR102096731B1 (ko) * | 2007-06-01 | 2020-04-02 | 오픈 모노클로날 테크놀로지, 인코포레이티드 | 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물 |
| JP5588866B2 (ja) * | 2007-08-10 | 2014-09-10 | メダレックス エル.エル.シー. | Hco32およびhco27、ならびに関連実施例 |
| WO2009023800A1 (en) * | 2007-08-14 | 2009-02-19 | Origen Therapeutics | Transgenic chickens with an inactivated endogenous gene locus |
| EP2108696A1 (en) * | 2008-04-10 | 2009-10-14 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Cis-acting diversification activator and method for selective diversification of nucleic acids |
| RU2011129459A (ru) * | 2008-12-18 | 2013-01-27 | Эрасмус Юниверсити Медикал Сентр Роттердам | Трансгенные животные (не человек), экспрессирующие гуманизированные антитела, и их применение |
| CN102638971B (zh) * | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| AU2010282508B2 (en) | 2009-08-13 | 2015-05-28 | Crystal Bioscience Inc. | Transgenic animal for production of antibodies having minimal CDRs |
| US8865462B2 (en) | 2010-01-20 | 2014-10-21 | Crystal Bioscience Inc. | Sustained culture of avian gonocytes |
| US10143186B2 (en) | 2010-02-08 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| KR101830020B1 (ko) * | 2010-03-31 | 2018-02-19 | 아블렉시스, 엘엘씨 | 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작 |
| SG10201504568YA (en) | 2010-06-22 | 2015-07-30 | Regeneron Pharma | Hybrid light chain mice |
| EP3960865A1 (en) | 2010-08-02 | 2022-03-02 | Regeneron Pharmaceuticals, Inc. | Mice that make binding proteins comprising vl domains |
| CN102250239B (zh) * | 2011-06-13 | 2013-04-17 | 中国农业科学院哈尔滨兽医研究所 | 一种与兔出血症病毒vp60蛋白相结合的蛋白及其应用 |
| HRP20192255T1 (hr) | 2011-08-05 | 2020-03-06 | Regeneron Pharmaceuticals, Inc. | Humanizirani miševi s univerzalnim lakim lancem |
| BR112014006390A2 (pt) * | 2011-09-19 | 2017-03-28 | Kymab Ltd | anticorpos, domínios variáveis e cadeias feitos especialmente para uso humano |
| HRP20220253T1 (hr) | 2011-10-17 | 2022-04-29 | Regeneron Pharmaceuticals, Inc. | Miševi s ograničenim teškim lancem imunoglobulina |
| ME03477B (me) | 2011-12-20 | 2020-01-20 | Regeneron Pharma | Miševi sa humanizovanim lakim lancem |
| HK1200849A1 (en) | 2011-12-22 | 2015-08-14 | F. Hoffmann-La Roche Ag | Full length antibody display system for eukaryotic cells and its use |
| SG10201913428QA (en) * | 2012-02-01 | 2020-03-30 | Regeneron Pharma | Humanized rodents that express heavy chains containing vl domains |
| SMT201800395T1 (it) | 2012-03-16 | 2018-09-13 | Regeneron Pharma | Anticorpi a catena leggera ingegnerizzati con istidina e roditori modificati geneticamente per la generazione degli stessi |
| PT2825037T (pt) | 2012-03-16 | 2019-08-07 | Regeneron Pharma | Animais não humanos que expressam sequências de imunoglobulinas sensíveis ao ph |
| KR102484480B1 (ko) | 2012-06-12 | 2023-01-04 | 리제너론 파마슈티칼스 인코포레이티드 | 제한된 면역글로불린 중쇄 유전자좌를 가지는 인간화된 비-인간 동물 |
| WO2014022853A1 (en) | 2012-08-03 | 2014-02-06 | Sanford Applied Biosciences, L.L.C. | Complex chromosome engineering for production of human antibodies in transgenic animals |
| LT2840892T (lt) | 2013-02-20 | 2018-07-25 | Regeneron Pharmaceuticals, Inc. | Nežmogaus tipo gyvūnai su modifikuotomis imunoglobulino sunkiųjų grandinių sekomis |
| SG11201506294TA (en) * | 2013-03-13 | 2015-09-29 | Regeneron Pharma | Common light chain mouse |
| LT3501272T (lt) * | 2013-03-13 | 2023-03-27 | Regeneron Pharmaceuticals, Inc. | Pelės, vykdančios imunoglobulino lengvosios grandinės riboto rinkinio raišką |
| TW201532513A (zh) * | 2014-01-10 | 2015-09-01 | Alfur Fu-Hsin Hung | 能產生比小鼠IgE量高出許多的人源化IgE之基因轉殖動物 |
| BR112016021679A2 (pt) | 2014-03-21 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | proteína de ligação ao antígeno, métodos de produção de uma proteína de ligação ao antígeno e de identificação de uma ou mais proteínas de ligação ao antígeno, hibridoma, ácido nucleico, célula, e, animal não humano geneticamente modificado. |
| SG10201808225TA (en) | 2014-03-21 | 2018-10-30 | Regeneron Pharma | Non-human animals that make single domain binding proteins |
| WO2015167011A1 (ja) * | 2014-05-02 | 2015-11-05 | 株式会社カイオム・バイオサイエンス | ヒト抗体を産生する細胞 |
| HK1250038A1 (zh) | 2015-03-19 | 2018-11-23 | 瑞泽恩制药公司 | 选择结合抗原的轻链可变区的非人动物 |
| EP3367786A1 (en) * | 2015-10-29 | 2018-09-05 | H. Hoffnabb-La Roche Ag | Transgenic rabbit with common light chain |
| EP3766343B1 (en) * | 2016-11-04 | 2022-05-11 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered immunoglobulin lambda light chain locus |
| CN110149809B (zh) | 2016-12-05 | 2023-04-14 | 皇家飞利浦有限公司 | 无线功率传输系统中的异物检测 |
| SG10202109874VA (en) | 2017-01-19 | 2021-10-28 | Open Monoclonal Tech Inc | Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci |
| WO2019129677A1 (en) | 2017-12-29 | 2019-07-04 | F. Hoffmann-La Roche Ag | Anti-vegf antibodies and methods of use |
| US20210000088A1 (en) * | 2018-03-21 | 2021-01-07 | Crystal Bioscience Inc. | Transgenic chicken that produces human antibodies |
| EP3990492A1 (en) | 2019-06-27 | 2022-05-04 | F. Hoffmann-La Roche AG | Novel icos antibodies and tumor-targeted antigen binding molecules comprising them |
| AR119382A1 (es) | 2019-07-12 | 2021-12-15 | Hoffmann La Roche | Anticuerpos de pre-direccionamiento y métodos de uso |
| AR119393A1 (es) | 2019-07-15 | 2021-12-15 | Hoffmann La Roche | Anticuerpos que se unen a nkg2d |
| CN110540996B (zh) * | 2019-08-29 | 2022-01-28 | 华中农业大学 | 一种克氏原螯虾i型溶菌酶gLysi2基因、其编码的gLysi2蛋白及其应用 |
| KR20220116490A (ko) * | 2019-12-18 | 2022-08-23 | 브리스톨-마이어스 스큅 컴퍼니 | 공통 리더 서열을 갖는 bcr 트랜스제닉 마우스 |
| CR20240246A (es) | 2021-12-20 | 2024-07-19 | Hoffmann La Roche | Anticuerpos agonistas anti-ltbr y anticuerpos biespecificos que los comprenden |
| CN114854901B (zh) * | 2022-06-22 | 2025-11-07 | 华南农业大学 | 与苦瓜全雌性状共分离的分子标记、引物及其应用 |
| WO2024261013A1 (en) | 2023-06-21 | 2024-12-26 | F. Hoffmann-La Roche Ag | Combination therapy with fap-targeted lymphotoxin beta receptor agonists |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE175234T1 (de) | 1990-07-10 | 1999-01-15 | Nippon Kokan Kk | Geflügelspezifischen immunglobulin g produzierende hybridomas |
| ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
| EP0583980A1 (en) | 1992-08-20 | 1994-02-23 | Eli Lilly And Company | Method for generating monoclonal antibodies from rabbits |
| WO1997016537A1 (en) | 1995-10-30 | 1997-05-09 | Spectral Diagnostics, Inc. | Stable chicken b-cell line and method of use thereof |
| DK1151010T3 (da) | 1999-02-05 | 2006-01-09 | Therapeutic Human Polyclonals | Humane polyklonale antistoffer fra antigene ikke-humane dyr |
| CA2375441A1 (en) | 1999-06-04 | 2000-12-14 | Tranxenogen, Inc. | Methods for manipulating the avian genome |
| WO2001019394A2 (en) | 1999-09-15 | 2001-03-22 | Therapeutic Human Polyclonals, Inc. | Immunotherapy with substantially human polyclonal antibody preparations purified from genetically engineered birds |
| WO2002012437A2 (en) * | 2000-08-03 | 2002-02-14 | Schooten Wim Van | Production of humanized antibodies in transgenic animals |
| AU2003261096B2 (en) | 2002-06-26 | 2008-10-02 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Gene regulation in transgenic animals using a transposon-based vector |
| CN1852925A (zh) * | 2003-07-15 | 2006-10-25 | 人类多克隆治疗公司 | 人源化免疫球蛋白基因座 |
| US20100286488A1 (en) | 2004-08-27 | 2010-11-11 | Moshe Cohen | Method and system for using a mobile device as a portable personal terminal for medical information |
| US20110077965A1 (en) | 2009-09-25 | 2011-03-31 | Cerner Innovation, Inc. | Processing event information of various sources |
| US20120306653A1 (en) | 2011-06-02 | 2012-12-06 | Nokia Siemens Networks Oy | Medical sensor |
| US20130021154A1 (en) | 2011-07-21 | 2013-01-24 | Solomon Clifford T | Medical parameters notification system |
-
2004
- 2004-07-15 CN CNA2004800261928A patent/CN1852925A/zh active Pending
- 2004-07-15 CN CN201210390234.2A patent/CN103205436B/zh not_active Expired - Lifetime
- 2004-07-15 CA CA2532117A patent/CA2532117C/en not_active Expired - Lifetime
- 2004-07-15 ES ES04778633.0T patent/ES2473596T3/es not_active Expired - Lifetime
- 2004-07-15 US US10/893,483 patent/US7585668B2/en active Active
- 2004-07-15 JP JP2006520411A patent/JP2007537704A/ja not_active Withdrawn
- 2004-07-15 EP EP04778633.0A patent/EP1644417B1/en not_active Expired - Lifetime
- 2004-07-15 AU AU2004257292A patent/AU2004257292A1/en not_active Abandoned
- 2004-07-15 WO PCT/US2004/023226 patent/WO2005007696A2/en not_active Ceased
- 2004-07-15 MX MXPA06000562A patent/MXPA06000562A/es unknown
-
2005
- 2005-12-29 IL IL172885A patent/IL172885A0/en unknown
-
2009
- 2009-07-29 US US12/511,188 patent/US8410333B2/en not_active Expired - Fee Related
-
2011
- 2011-06-14 JP JP2011131898A patent/JP6017763B2/ja not_active Expired - Lifetime
-
2013
- 2013-02-27 US US13/779,585 patent/US8652842B2/en not_active Ceased
-
2016
- 2016-02-09 US US15/019,852 patent/USRE47131E1/en not_active Expired - Fee Related
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