JP2011182801A5 - - Google Patents
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- Publication number
- JP2011182801A5 JP2011182801A5 JP2011131898A JP2011131898A JP2011182801A5 JP 2011182801 A5 JP2011182801 A5 JP 2011182801A5 JP 2011131898 A JP2011131898 A JP 2011131898A JP 2011131898 A JP2011131898 A JP 2011131898A JP 2011182801 A5 JP2011182801 A5 JP 2011182801A5
- Authority
- JP
- Japan
- Prior art keywords
- gene segment
- humanized
- locus
- gene
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48773303P | 2003-07-15 | 2003-07-15 | |
| US60/487,733 | 2003-07-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520411A Division JP2007537704A (ja) | 2003-07-15 | 2004-07-15 | ヒト化免疫グロブリン遺伝子座 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011182801A JP2011182801A (ja) | 2011-09-22 |
| JP2011182801A5 true JP2011182801A5 (enExample) | 2012-07-19 |
| JP6017763B2 JP6017763B2 (ja) | 2016-11-02 |
Family
ID=34079388
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520411A Withdrawn JP2007537704A (ja) | 2003-07-15 | 2004-07-15 | ヒト化免疫グロブリン遺伝子座 |
| JP2011131898A Expired - Lifetime JP6017763B2 (ja) | 2003-07-15 | 2011-06-14 | ヒト化免疫グロブリン遺伝子座 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520411A Withdrawn JP2007537704A (ja) | 2003-07-15 | 2004-07-15 | ヒト化免疫グロブリン遺伝子座 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US7585668B2 (enExample) |
| EP (1) | EP1644417B1 (enExample) |
| JP (2) | JP2007537704A (enExample) |
| CN (2) | CN103205436B (enExample) |
| AU (1) | AU2004257292A1 (enExample) |
| CA (1) | CA2532117C (enExample) |
| ES (1) | ES2473596T3 (enExample) |
| IL (1) | IL172885A0 (enExample) |
| MX (1) | MXPA06000562A (enExample) |
| WO (1) | WO2005007696A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| CN103205436B (zh) * | 2003-07-15 | 2016-05-25 | 人类多克隆治疗公司 | 人源化免疫球蛋白基因座 |
| US20100034782A1 (en) * | 2006-05-31 | 2010-02-11 | Nader Najafian | Methods of Using Anti-Thymocyte Globulin and Related Agents |
| ES2378407T3 (es) * | 2006-09-01 | 2012-04-12 | Therapeutic Human Polyclonals, Inc. | Aumento de la expresión de inmunoglobulina humana o humanizada en animales transgénicos no humanos |
| US20090053210A1 (en) | 2006-09-01 | 2009-02-26 | Roland Buelow | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| CA2688834C (en) | 2007-06-01 | 2020-01-07 | Ronald Buelow | Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies |
| WO2009097006A2 (en) * | 2007-08-10 | 2009-08-06 | Medarex, Inc. | Hco32 and hco27 and related examples |
| WO2009023800A1 (en) * | 2007-08-14 | 2009-02-19 | Origen Therapeutics | Transgenic chickens with an inactivated endogenous gene locus |
| EP2108696A1 (en) * | 2008-04-10 | 2009-10-14 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Cis-acting diversification activator and method for selective diversification of nucleic acids |
| CA2747534C (en) * | 2008-12-18 | 2020-08-18 | Erasmus University Medical Center Rotterdam | Non-human transgenic animals expressing humanised antibodies and use therof |
| CN102638971B (zh) * | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| US8592644B2 (en) * | 2009-08-13 | 2013-11-26 | Crystal Bioscience Inc. | Transgenic animal for production of antibodies having minimal CDRS |
| US8865462B2 (en) | 2010-01-20 | 2014-10-21 | Crystal Bioscience Inc. | Sustained culture of avian gonocytes |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| HRP20151188T4 (hr) | 2010-02-08 | 2021-10-01 | Regeneron Pharmaceuticals, Inc. | Miš sa zajedničkim lakim lancem |
| PL3251503T3 (pl) * | 2010-03-31 | 2024-07-08 | Ablexis, Llc | Modyfikacja myszy metodami inżynierii genetycznej w celu wytworzenia przeciwciał chimerycznych |
| SI2480675T1 (sl) | 2010-06-22 | 2016-08-31 | Regeneron Pharmaceuticals, Inc. | Miši, ki izražajo lahko verigo s spremenljivo regijo humanega lambda in konstantno mišjo regijo |
| KR102306967B1 (ko) | 2010-08-02 | 2021-10-01 | 리제너론 파아마슈티컬스, 인크. | Ｖｌ 도메인을 포함하는 결합 단백질을 생성하는 마우스 |
| CN102250239B (zh) * | 2011-06-13 | 2013-04-17 | 中国农业科学院哈尔滨兽医研究所 | 一种与兔出血症病毒vp60蛋白相结合的蛋白及其应用 |
| PT3865581T (pt) | 2011-08-05 | 2024-10-04 | Regeneron Pharma | Murganhos da cadeia leve universal humanizada |
| AU2012311286B2 (en) * | 2011-09-19 | 2018-07-26 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| KR20140082824A (ko) | 2011-10-17 | 2014-07-02 | 리제너론 파아마슈티컬스, 인크. | 제한된 면역글로불린 중쇄 마우스 |
| PT3527070T (pt) | 2011-12-20 | 2025-12-19 | Regeneron Pharma | Murganhos de cadeia leve humanizada |
| CN104011080B (zh) | 2011-12-22 | 2017-10-20 | 弗·哈夫曼-拉罗切有限公司 | 用于真核细胞的全长抗体展示系统及其用途 |
| NZ810648A (en) * | 2012-02-01 | 2025-11-28 | Regeneron Pharma | Humanized rodents that express heavy chains containing vl domains |
| DK2825036T3 (en) | 2012-03-16 | 2018-07-16 | Regeneron Pharma | Histidine engineered light chain antibodies and genetically modified rodents to generate them |
| KR102213535B1 (ko) | 2012-03-16 | 2021-02-08 | 리제너론 파마슈티칼스 인코포레이티드 | pH-민감성 면역글로불린 서열을 발현하는 비-사람 동물 |
| EP3912464A1 (en) | 2012-06-12 | 2021-11-24 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
| KR102159163B1 (ko) | 2012-08-03 | 2020-09-23 | 에스에이비, 엘엘씨 | 유전자삽입 동물에서 인간 항체의 제조를 위한 복합 염색체 조작 |
| MY185881A (en) | 2013-02-20 | 2021-06-14 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
| EP4218409B1 (en) * | 2013-03-13 | 2025-02-12 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| JP2016519568A (ja) * | 2013-03-13 | 2016-07-07 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 共通軽鎖のマウス |
| US20170101460A1 (en) * | 2014-01-10 | 2017-04-13 | Allermabs Co. Ltd. | Transgenic animals capable of producing humanized ige at much higher levels than mouse ige |
| CN106164092A (zh) | 2014-03-21 | 2016-11-23 | 瑞泽恩制药公司 | 表现不同结合特征的vl抗原结合蛋白 |
| CN106255410B (zh) | 2014-03-21 | 2020-01-10 | 瑞泽恩制药公司 | 产生单结构域结合蛋白的非人动物 |
| CN112877292A (zh) * | 2014-05-02 | 2021-06-01 | 凯奥目生物科学株式会社 | 产生人抗体的细胞 |
| US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| CN113862300A (zh) * | 2015-10-29 | 2021-12-31 | 豪夫迈·罗氏有限公司 | 具有共同轻链的转基因兔 |
| PT4082334T (pt) * | 2016-11-04 | 2025-05-21 | Regeneron Pharma | Animais não humanos possuindo um lócus da cadeia leve lambda de immunoglobulina geneticamente modificada |
| CN110149809B (zh) | 2016-12-05 | 2023-04-14 | 皇家飞利浦有限公司 | 无线功率传输系统中的异物检测 |
| US12016313B2 (en) * | 2017-01-19 | 2024-06-25 | Omniab Operations, Inc. | Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci |
| WO2019129679A1 (en) | 2017-12-29 | 2019-07-04 | F. Hoffmann-La Roche Ag | Method for improving vegf-receptor blocking selectivity of an anti-vegf antibody |
| US20210000088A1 (en) * | 2018-03-21 | 2021-01-07 | Crystal Bioscience Inc. | Transgenic chicken that produces human antibodies |
| EP3990492A1 (en) | 2019-06-27 | 2022-05-04 | F. Hoffmann-La Roche AG | Novel icos antibodies and tumor-targeted antigen binding molecules comprising them |
| AR119382A1 (es) | 2019-07-12 | 2021-12-15 | Hoffmann La Roche | Anticuerpos de pre-direccionamiento y métodos de uso |
| AR119393A1 (es) | 2019-07-15 | 2021-12-15 | Hoffmann La Roche | Anticuerpos que se unen a nkg2d |
| CN110540996B (zh) * | 2019-08-29 | 2022-01-28 | 华中农业大学 | 一种克氏原螯虾i型溶菌酶gLysi2基因、其编码的gLysi2蛋白及其应用 |
| EP4075965A1 (en) * | 2019-12-18 | 2022-10-26 | Bristol-Myers Squibb Company | Bcr transgenic mice with a common leader sequence |
| CR20240246A (es) | 2021-12-20 | 2024-07-19 | Hoffmann La Roche | Anticuerpos agonistas anti-ltbr y anticuerpos biespecificos que los comprenden |
| CN114854901B (zh) * | 2022-06-22 | 2025-11-07 | 华南农业大学 | 与苦瓜全雌性状共分离的分子标记、引物及其应用 |
| AU2024311339A1 (en) | 2023-06-21 | 2026-01-08 | F. Hoffmann-La Roche Ag | Combination therapy with fap-targeted lymphotoxin beta receptor agonists |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2066433A1 (en) | 1990-07-10 | 1992-01-11 | Haruo Matsuda | Chicken-specific immunoglobulin g-producing hybridoma |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| EP0583980A1 (en) | 1992-08-20 | 1994-02-23 | Eli Lilly And Company | Method for generating monoclonal antibodies from rabbits |
| WO1997016537A1 (en) | 1995-10-30 | 1997-05-09 | Spectral Diagnostics, Inc. | Stable chicken b-cell line and method of use thereof |
| DE60023451T2 (de) | 1999-02-05 | 2006-07-20 | Therapeutic Human Polyclonals, Inc., Mountain View | Aus nicht-menschlichen transgenen tieren gewonnene menschliche polyklonale antikörper |
| WO2000075300A2 (en) | 1999-06-04 | 2000-12-14 | Tranxenogen, Inc. | Methods for manipulating the avian genome |
| WO2001019394A2 (en) | 1999-09-15 | 2001-03-22 | Therapeutic Human Polyclonals, Inc. | Immunotherapy with substantially human polyclonal antibody preparations purified from genetically engineered birds |
| EP1311530A4 (en) | 2000-08-03 | 2004-10-06 | Wim-Van Schooten | PRODUCTION OF HUMANIZED ANTIBODIES IN TRANSGENIC ANIMALS |
| ATE430756T1 (de) | 2002-06-26 | 2009-05-15 | Transgenrx Inc | Genregulation in transgenen tieren unter verwendung eines vektors auf transposonbasis |
| CN103205436B (zh) * | 2003-07-15 | 2016-05-25 | 人类多克隆治疗公司 | 人源化免疫球蛋白基因座 |
| US20100286488A1 (en) | 2004-08-27 | 2010-11-11 | Moshe Cohen | Method and system for using a mobile device as a portable personal terminal for medical information |
| US20110077965A1 (en) | 2009-09-25 | 2011-03-31 | Cerner Innovation, Inc. | Processing event information of various sources |
| US20120306653A1 (en) | 2011-06-02 | 2012-12-06 | Nokia Siemens Networks Oy | Medical sensor |
| US20130021154A1 (en) | 2011-07-21 | 2013-01-24 | Solomon Clifford T | Medical parameters notification system |
-
2004
- 2004-07-15 CN CN201210390234.2A patent/CN103205436B/zh not_active Expired - Lifetime
- 2004-07-15 EP EP04778633.0A patent/EP1644417B1/en not_active Expired - Lifetime
- 2004-07-15 CA CA2532117A patent/CA2532117C/en not_active Expired - Lifetime
- 2004-07-15 ES ES04778633.0T patent/ES2473596T3/es not_active Expired - Lifetime
- 2004-07-15 WO PCT/US2004/023226 patent/WO2005007696A2/en not_active Ceased
- 2004-07-15 AU AU2004257292A patent/AU2004257292A1/en not_active Abandoned
- 2004-07-15 US US10/893,483 patent/US7585668B2/en active Active
- 2004-07-15 CN CNA2004800261928A patent/CN1852925A/zh active Pending
- 2004-07-15 JP JP2006520411A patent/JP2007537704A/ja not_active Withdrawn
- 2004-07-15 MX MXPA06000562A patent/MXPA06000562A/es unknown
-
2005
- 2005-12-29 IL IL172885A patent/IL172885A0/en unknown
-
2009
- 2009-07-29 US US12/511,188 patent/US8410333B2/en not_active Expired - Fee Related
-
2011
- 2011-06-14 JP JP2011131898A patent/JP6017763B2/ja not_active Expired - Lifetime
-
2013
- 2013-02-27 US US13/779,585 patent/US8652842B2/en not_active Ceased
-
2016
- 2016-02-09 US US15/019,852 patent/USRE47131E1/en not_active Expired - Fee Related
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