JP2011182801A5 - - Google Patents

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Publication number
JP2011182801A5
JP2011182801A5 JP2011131898A JP2011131898A JP2011182801A5 JP 2011182801 A5 JP2011182801 A5 JP 2011182801A5 JP 2011131898 A JP2011131898 A JP 2011131898A JP 2011131898 A JP2011131898 A JP 2011131898A JP 2011182801 A5 JP2011182801 A5 JP 2011182801A5
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JP
Japan
Prior art keywords
gene segment
humanized
locus
gene
nucleic acid
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JP2011131898A
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English (en)
Japanese (ja)
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JP2011182801A (ja
JP6017763B2 (ja
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Publication of JP2011182801A publication Critical patent/JP2011182801A/ja
Publication of JP2011182801A5 publication Critical patent/JP2011182801A5/ja
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Publication of JP6017763B2 publication Critical patent/JP6017763B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2011131898A 2003-07-15 2011-06-14 ヒト化免疫グロブリン遺伝子座 Expired - Lifetime JP6017763B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48773303P 2003-07-15 2003-07-15
US60/487,733 2003-07-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2006520411A Division JP2007537704A (ja) 2003-07-15 2004-07-15 ヒト化免疫グロブリン遺伝子座

Publications (3)

Publication Number Publication Date
JP2011182801A JP2011182801A (ja) 2011-09-22
JP2011182801A5 true JP2011182801A5 (enExample) 2012-07-19
JP6017763B2 JP6017763B2 (ja) 2016-11-02

Family

ID=34079388

Family Applications (2)

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JP2006520411A Withdrawn JP2007537704A (ja) 2003-07-15 2004-07-15 ヒト化免疫グロブリン遺伝子座
JP2011131898A Expired - Lifetime JP6017763B2 (ja) 2003-07-15 2011-06-14 ヒト化免疫グロブリン遺伝子座

Family Applications Before (1)

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JP2006520411A Withdrawn JP2007537704A (ja) 2003-07-15 2004-07-15 ヒト化免疫グロブリン遺伝子座

Country Status (10)

Country Link
US (4) US7585668B2 (enExample)
EP (1) EP1644417B1 (enExample)
JP (2) JP2007537704A (enExample)
CN (2) CN103205436B (enExample)
AU (1) AU2004257292A1 (enExample)
CA (1) CA2532117C (enExample)
ES (1) ES2473596T3 (enExample)
IL (1) IL172885A0 (enExample)
MX (1) MXPA06000562A (enExample)
WO (1) WO2005007696A2 (enExample)

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SMT201700023T1 (it) 2010-08-02 2017-03-08 Regeneron Pharma Topi che producono proteine leganti vl
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HUE047278T2 (hu) 2011-08-05 2020-04-28 Regeneron Pharma Humanizált univerzális könnyûláncú egerek
BR112014006394A2 (pt) * 2011-09-19 2017-03-28 Kymab Ltd manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos
SG11201401181YA (en) 2011-10-17 2014-04-28 Regeneron Pharma Restricted immunoglobulin heavy chain mice
SG10201605675WA (en) 2011-12-20 2016-09-29 Regeneron Pharma Humanized light chain mice
CN104011080B (zh) 2011-12-22 2017-10-20 弗·哈夫曼-拉罗切有限公司 用于真核细胞的全长抗体展示系统及其用途
EP3597038B1 (en) * 2012-02-01 2021-04-21 Regeneron Pharmaceuticals, Inc. Humanized rodents that express heavy chains containing vl domains
EP2825036B1 (en) 2012-03-16 2018-05-02 Regeneron Pharmaceuticals, Inc. Histidine engineered light chain antibodies and genetically modified rodents for generating the same
EP3539374A1 (en) 2012-03-16 2019-09-18 Regeneron Pharmaceuticals, Inc. Non-human animals expressing ph-sensitive immunoglobulin sequences
ME03551B (me) 2012-06-12 2020-07-20 Regeneron Pharma Humanizovane nehumane živoтinje sa ograničenim lokusima imunoglobulinskog тeškog lanca
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