JP2021526830A5 - - Google Patents

Info

Publication number
JP2021526830A5
JP2021526830A5 JP2020569001A JP2020569001A JP2021526830A5 JP 2021526830 A5 JP2021526830 A5 JP 2021526830A5 JP 2020569001 A JP2020569001 A JP 2020569001A JP 2020569001 A JP2020569001 A JP 2020569001A JP 2021526830 A5 JP2021526830 A5 JP 2021526830A5
Authority
JP
Japan
Prior art keywords
heavy chain
variable domain
transgenic
gene
transgenic chicken
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020569001A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021526830A (ja
JP7515410B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/035540 external-priority patent/WO2019241002A1/en
Publication of JP2021526830A publication Critical patent/JP2021526830A/ja
Publication of JP2021526830A5 publication Critical patent/JP2021526830A5/ja
Application granted granted Critical
Publication of JP7515410B2 publication Critical patent/JP7515410B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020569001A 2018-06-13 2019-06-05 複数のジスルフィド架橋によって安定化され、遺伝子変換によって多様化された長いｃｄｒ－ｈ３ｓで抗体を作製するトランスジェニックニワトリ Active JP7515410B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862684669P 2018-06-13 2018-06-13
US62/684,669 2018-06-13
PCT/US2019/035540 WO2019241002A1 (en) 2018-06-13 2019-06-05 Transgenic chicken that makes antibodies with long cdr-h3s stabilized by multiple disulfide bridges and diversified by gene conversion

Publications (3)

Publication Number Publication Date
JP2021526830A JP2021526830A (ja) 2021-10-11
JP2021526830A5 true JP2021526830A5 (enExample) 2022-06-09
JP7515410B2 JP7515410B2 (ja) 2024-07-12

Family

ID=68842113

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020569001A Active JP7515410B2 (ja) 2018-06-13 2019-06-05 複数のジスルフィド架橋によって安定化され、遺伝子変換によって多様化された長いｃｄｒ－ｈ３ｓで抗体を作製するトランスジェニックニワトリ

Country Status (7)

Country Link
US (2) US12428471B2 (enExample)
EP (1) EP3813520A4 (enExample)
JP (1) JP7515410B2 (enExample)
KR (1) KR20210021002A (enExample)
AU (2) AU2019284256B2 (enExample)
CA (1) CA3102125A1 (enExample)
WO (1) WO2019241002A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202430558A (zh) 2023-01-18 2024-08-01 美商基利科學股份有限公司 人類免疫球蛋白重鏈長cdr3轉殖基因構築體及其用途

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DE229046T1 (de) 1985-03-30 1987-12-17 Marc Genf/Geneve Ballivet Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren.
US6492107B1 (en) 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
DE3600905A1 (de) 1986-01-15 1987-07-16 Ant Nachrichtentech Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4977081A (en) 1987-05-04 1990-12-11 Adi Diagnostics, Inc. Stable rabbit-mouse hybridomas and secretion products thereof
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
CA2016842A1 (en) 1989-05-16 1990-11-16 Richard A. Lerner Method for tapping the immunological repertoire
AU652539B2 (en) 1989-05-16 1994-09-01 Medical Research Council Co-expression of heteromeric receptors
CA2016841C (en) 1989-05-16 1999-09-21 William D. Huse A method for producing polymers having a preselected activity
AU8212291A (en) 1990-07-10 1992-02-04 Nkk Corporation Hybridoma which produces avian specific immunoglobulin g
US7041871B1 (en) * 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
EP0571613B1 (en) 1991-12-13 2003-09-17 Xoma Corporation Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
EP0583980A1 (en) 1992-08-20 1994-02-23 Eli Lilly And Company Method for generating monoclonal antibodies from rabbits
AU7326796A (en) 1995-10-30 1997-05-22 Spectral Diagnostics Inc. Stable chicken b-cell line and method of use thereof
US5714352A (en) 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
WO2005005604A2 (en) 2003-06-30 2005-01-20 Centocor, Inc. Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses
PL2602323T3 (pl) * 2007-06-01 2018-06-29 Open Monoclonal Technology, Inc. Kompozycje i sposoby hamowania endogennych genów immunoglobin i wytwarzania transgenicznych ludzkich przeciwciał typu idiotypowego
JP5470817B2 (ja) 2008-03-10 2014-04-16 日産自動車株式会社 電池用電極およびこれを用いた電池、並びにその製造方法
WO2010101802A2 (en) 2009-03-02 2010-09-10 University Of Georgia Research Foundation, Inc. Method to alter sex ratios in avian offspring
GB0905023D0 (en) * 2009-03-24 2009-05-06 Univ Erasmus Medical Ct Binding molecules
AU2010282508B2 (en) * 2009-08-13 2015-05-28 Crystal Bioscience Inc. Transgenic animal for production of antibodies having minimal CDRs
ES2724975T3 (es) * 2009-12-10 2019-09-18 Regeneron Pharma Ratones que producen anticuerpos de cadena pesada
US9394372B2 (en) * 2011-10-21 2016-07-19 Crystal Bioscience Inc. In vivo method for generating diversity in a protein scaffold
CA2863224A1 (en) 2012-01-09 2013-07-18 The Scripps Research Institute Ultralong complementarity determining regions and uses thereof
JP6136279B2 (ja) 2013-01-15 2017-05-31 株式会社ジェイテクト 転がり軸受装置
TWI503850B (zh) 2013-03-22 2015-10-11 Polytronics Technology Corp 過電流保護元件
CA2918370A1 (en) * 2013-07-18 2015-01-22 Fabrus, Inc. Humanized antibodies with ultralong complementarity determining regions
TWI510996B (zh) 2013-10-03 2015-12-01 Acer Inc 控制觸控面板的方法以及使用該方法的可攜式電腦
EP3138903B1 (en) * 2014-05-02 2022-02-09 Chiome Bioscience Inc. Cells for producing human antibody
US9816280B1 (en) 2016-11-02 2017-11-14 Matthew Reitnauer Portable floor

Similar Documents

Publication Publication Date Title
DK2509409T3 (en) MICE, WHICH PRODUCES HEAVY CHAIN ANTIBODIES
JP2015519076A5 (enExample)
JP2015505477A5 (enExample)
HRP20201403T1 (hr) Neljudske životinje koje imaju genetski modificiran lokus imunoglobulinskog lambda lakog lanca
JP2011182801A5 (enExample)
CA2532117A1 (en) Humanized immunoglobulin loci
JP2020530760A5 (enExample)
RU2014153673A (ru) Гуманизированные не относящиеся к человеку животные с ограниченными локусами тяжелой цепи иммуноглобулина
AR047372A1 (es) Anticuerpos contra madcam
FI4023059T3 (fi) Ei-ihmiseläimiä, jotka kykenevät DH-DH-uudelleenjärjestymiseen immunoglobuliinin raskasketjun koodaussekvensseissä
KR102139388B1 (ko) 친화성 성숙 인간 항체의 동정
JP2010527622A5 (enExample)
JP2021528057A5 (enExample)
JP7085992B2 (ja) 共通軽鎖を有するトランスジェニックウサギ
US20250388651A1 (en) Transgenic chicken that makes antibodies with long cdr-h3s stabilized by multiple disulfide bridges and diversified by gene conversion
JP2021526830A5 (enExample)
US12568940B2 (en) Transgenic chicken having an endogenous immunoglobulin heavy chain gene in which the IgY CH1 coding sequence is functionally deleted
EP4346396A1 (en) Animal models and therapeutic molecules
JP2024501286A5 (enExample)
JP2022517865A5 (enExample)
JP2021526828A5 (enExample)
AU2023286840A1 (en) Animal models and therapeutic molecules
JP2024543248A5 (enExample)
JP2023508290A5 (enExample)
RU2021135460A (ru) Мыши с гуманизированной легкой цепью